Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05165 (show subtarget assignments)	1	soluble	No	BA_1888	30256549		enterotoxin [Bacillus anthracis str. Ame...	402	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NRJ	24.6%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP00647 (show subtarget assignments)	1	selected	No	SACOL1657	57286179		enterotoxin type A, putative	234	Virulence Associated Factor	Phase 2: March 2008	1ESF	40.2%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00272 (show subtarget assignments)	1	in_pdb 3EGP 3IRC	No	AF180817_281-775	7329982	N/A	Envelope (E)	495	Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...	Phase 1: October 2007	3G7T	78.8%	Dengue virus		N/A

IDP00280 (show subtarget assignments)	1	purified	No	AAX48017_51-545	604449	N/A	Envelope (E)	495	Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...	Phase 3: June 2008	3UAJ	79.2%	Dengue virus		N/A

IDP91731 (show subtarget assignments)	8	selected	No	NP_958854	41393583	EGFL7	epidermal growth factor-like protein 7 [...	273	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2W86	15.8%	Homo sapiens

IDP00629 (show subtarget assignments)	1	in_pdb 3QJG	No	SACOL1875	57284796	epiD	epidermin biosynthesis protein EpiD	172	Conserved Gene / Pathway	Phase 2: March 2008	3QJG	100%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00811 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1873	57284794	epiF	epidermin immunity protein F	230	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	33.6%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00624 (show subtarget assignments)	8	in_pdb 3T41 3QFH	No	SACOL1874	57284795	epiP	epidermin leader peptide processing seri...	457	Drug Target Function	Community Requests	3QFH	94.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP91545 (show subtarget assignments)	8	expressed	No	AAC78336	3892237	ereA2	erythromycin esterase [Providencia stuar...	408	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Providencia stuartii

IDP91544 (show subtarget assignments)	8	in_crystallization_trials	No	BAE54319	83627318	ereB	erythromycin esterase type II [Escherich...	419	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2QGM	25.8%	Escherichia coli

IDP90820 (show subtarget assignments)	8	in_pdb 3OET	No	STM2370	16765697	pdxB	erythronate-4-phosphate dehydrogenase [S...	378	Predicted Essential	Community Requests	3OET	100%	Salmonella enterica

IDP90773 (show subtarget assignments)	8	selected	No	VC2108	15642108		erythronate-4-phosphate dehydrogenase [V...	387	Predicted Essential	Community Requests	3OET	48.3%	Vibrio cholerae

IDP91610 (show subtarget assignments)	8	in_crystallization_trials	No	BAB37977	13364029	ECs4554	EspB protein [Escherichia coli O157:H7 s...	312	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP91616 (show subtarget assignments)	8	soluble	No	BAB36138	13362183	ECs2715	EspF-like protein [Escherichia coli O157...	337	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KXC	13.9%	Escherichia coli

IDP91577 (show subtarget assignments)	8	purified	No	BAB37973	13364025	ECs4550	EspF protein [Escherichia coli O157:H7 s...	248	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP05523 (show subtarget assignments)	1	soluble	No	CD2204	126699821		esterase [Clostridium difficile 630]	260	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2UZ0	33.5%	Clostridium difficile	Fatty acid and phospholipid metabolism: Degradation

IDP91527 (show subtarget assignments)	8	cloned	No	AAX13509	89214483	etpA	EtpA [Escherichia coli ETEC H10407]	1767	virulence/pathogenesis / The EtpA ETEC two-partner secretion (TPS) exoprotein [PMID: 16552055] is a highl...	Community Requests	3AK5	11.2%	Escherichia coli

IDP90294 (show subtarget assignments)	8	expressed	No	TGME49_113230	211962198		eukaryotic translation initiation factor...	347	Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...	Community Requests	1Q8K	40.3%	Toxoplasma gondii

IDP04218 (show subtarget assignments)	1	expressed	No	STM2996_1_1123	16766298	recC	exonuclease V subunit gamma [Salmonella ...	1123	Salmonella essential protein	Phase 4: April 2009	1W36	88.4%	Salmonella enterica

IDP02550 (show subtarget assignments)	1	in_pdb 3RF0	Yes	YPO2837	16123032	ppx	exopolyphosphatase [Yersinia pestis CO92...	519	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1U6Z	76.3%	Yersinia pestis	Central intermediary metabolism	Phosphorus compounds

IDP00131 (show subtarget assignments)	0	work_stopped	No	NT01ST2113	16765046	rnb	exoribonuclease II	644	Essential	Phase 1: October 2007	2ID0	90.7%	Salmonella enterica	Transcription	Degradation of RNA

IDP05644 (show subtarget assignments)	1	cloned	No	CD3230	126700850	bclA2	exosporium glycoprotein [Clostridium dif...	558	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	35.3%	Clostridium difficile	Unclassified: Role category not yet assigned

IDP91634 (show subtarget assignments)	8	selected	No	AAC16023	2429143	exoU	ExoU [Pseudomonas aeruginosa]	687	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	4AKX	95.8%	Pseudomonas aeruginosa

IDP02717 (show subtarget assignments)	1	cloned	No	GBAA3854	47529142	chi36	extracellular exochitinase Chi36 [Bacill...	360	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N11	88.6%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP91953 (show subtarget assignments)	8	cloned	No	SpneCM_010100002215	298254414		extracellular solute-binding lipoprotein...	442	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QUF	20.6%	Streptococcus pneumoniae

IDP04240 (show subtarget assignments)	1	cloned	No	CPF_1077	110800997		extracellular solute-binding protein [Cl...	477	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W7Y	15.3%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04378 (show subtarget assignments)	1	cloned	No	CPF_2335	110799804		extracellular solute-binding protein [Cl...	482	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP01699 (show subtarget assignments)	1	purified	No	YPO3343	16123493		extracellular solute-binding protein [Ye...	256	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3KBR	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP91702 (show subtarget assignments)	8	selected	No	NP_003370	21614499	EZR	ezrin [Homo sapiens]	586	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2I1J	56.9%	Homo sapiens

IDP01821 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5549	47530869	atpA	F0F1 ATP synthase subunit alpha [Bacillu...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	84.5%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP01802 (show subtarget assignments)	1	crystallized	No	FTT0062	56707241	atpA	F0F1 ATP synthase subunit alpha [Francis...	513	Conserved; Drug target functions	Phase 3: June 2008	3OAA	71%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02711 (show subtarget assignments)	1	cloned	No	GBAA5551	47530871	atpF	F0F1 ATP synthase subunit B [Bacillus an...	168	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP01832 (show subtarget assignments)	1	expressed	No	GBAA5547	47530867	atpD	F0F1 ATP synthase subunit beta [Bacillus...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	86.4%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02648 (show subtarget assignments)	1	soluble	No	FTT0064	56707243	atpD	F0F1 ATP synthase subunit beta [Francise...	458	Conserved; Drug target functions	Phase 3: June 2008	3OAA	81.3%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP01933 (show subtarget assignments)	1	soluble	No	FTT0061	56707240	atpH	F0F1 ATP synthase subunit delta [Francis...	174	Conserved; Drug target functions	Phase 3: June 2008	2WSS	28.2%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02577 (show subtarget assignments)	1	purified	No	GBAA5546	47530866	atpC	F0F1 ATP synthase subunit epsilon [Bacil...	133	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E5Y	69.9%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02182 (show subtarget assignments)	1	cloned	No	FTT0065	56707244	atpC	F0F1 ATP synthase subunit epsilon [Franc...	145	Conserved; Drug target functions	Phase 3: June 2008	2QE7	33.1%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP01863 (show subtarget assignments)	1	cloned	No	GBAA5548	47778410	atpG	F0F1 ATP synthase subunit gamma [Bacillu...	286	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QE7	58.7%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02177 (show subtarget assignments)	1	soluble	No	FTT0063	56707242	atpG	F0F1 ATP synthase subunit gamma [Francis...	298	Conserved; Drug target functions	Phase 3: June 2008	3OAA	49.7%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP91252 (show subtarget assignments)	8	soluble	No	NT01LM1948	16411261	fabG	fabG [Listeria monocytogenes]	247	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2UVD	66.4%	Listeria monocytogenes	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90343 (show subtarget assignments)	8	expressed	No	CT148	15604867	mhpA	FAD-dependent monooxygenase [Chlamydia t...	507	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP92553 (show subtarget assignments)	8	selected	No	VV1_2233	27361706	fadR	fatty acid metabolism transcriptional re...	279	potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...	Community Requests	1E2X	52%	Vibrio vulnificus

IDP00955 (show subtarget assignments)	1	cloned	No	STM1192	16764547	plsX	fatty acid/phospholipid synthesis protei...	359	Conserved Gene / Pathway	Phase 2: March 2008	1U7N	36.5%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04082 (show subtarget assignments)	1	cloned	No	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04410 (show subtarget assignments)	1	cloned	No	VC1047	9655512		fatty oxidation complex, alpha subunit [...	724	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1WDK	36.4%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP00108 (show subtarget assignments)	1	purified	No	NT01SF4751	30043076	fdhE	FdhE protein	309	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FIY	39.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00822 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2253	57285032	femX	femX protein	421	Conserved Gene / Pathway	Phase 2: March 2008	1LRZ	26.7%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01812 (show subtarget assignments)	1	cloned	No	FTT1764c	56708759		ferredoxin [Francisella tularensis subsp...	107	Conserved; Drug target functions	Phase 3: June 2008	1A6L	64.5%	Francisella tularensis	Energy metabolism	Electron transport

IDP01074 (show subtarget assignments)	1	in_pdb 3FPK	Yes	STM4084	16767350	fpr	ferredoxin-NADP reductase	248	Conserved Gene / Pathway	Phase 2: March 2008	3FPK	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP91439 (show subtarget assignments)	8	cloned	No	VV1_0471	27363938		ferredoxin [Vibrio vulnificus CMCP6]	84	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2ZVS	65.5%	Vibrio vulnificus

IDP00911 (show subtarget assignments)	1	expressed	No	STM0191	16763581	fhuA	ferrichrome outer membrane transporter	729	Conserved Gene / Pathway	Phase 2: March 2008	2FCP	72.3%	Salmonella enterica	Cell envelope	Other

IDP91017 (show subtarget assignments)	8	expressed	No	y2556	22126437	fcuA	ferrichrome receptor, TonB dependent [Ye...	776	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	3QLB	23.6%	Yersinia pestis

IDP01341 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0687	15601444	fbpC	ferric transporter ATP-binding subunit	351	Conserved Gene / Pathway	Phase 2: March 2008	1V43	38.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01129 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5296	30259774		ferritin	168	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	48.2%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01358 (show subtarget assignments)	1	in_pdb 3QZ3	Yes	VC0078	15640110		ferritin	181	Conserved Gene / Pathway	Phase 2: March 2008	3QZ3	100%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00977 (show subtarget assignments)	1	expressed	No	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00611 (show subtarget assignments)	1	crystallized	No	SACOL1952	57286299		ferritins family protein	166	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	39.2%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP02347 (show subtarget assignments)	1	soluble	No	YPO1783	16122037	ftnA	ferritin [Yersinia pestis CO92]	169	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QZ3	68.6%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00092 (show subtarget assignments)	1	expressed	No	NT01SF0466	30040219	hemH	ferrochelatase	320	Essential	Phase 1: October 2007	1L8X	27.9%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04666 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1158	47526425	hemH-2	ferrochelatase [Bacillus anthracis str. ...	319	putative drug target function;	Phase 4: April 2009	2C8J	62.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90719 (show subtarget assignments)	8	soluble	No	Cj0503c	15791865	hemH	ferrochelatase [Campylobacter jejuni sub...	303	Predicted Essential	Community Requests	2PO7	31%	Campylobacter jejuni

IDP02423 (show subtarget assignments)	1	cloned	No	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90812 (show subtarget assignments)	8	soluble	No	YPO3117	16123282	hemH	ferrochelatase [Yersinia pestis CO92]	320	Predicted Essential	Community Requests	2QD2	26.2%	Yersinia pestis

IDP00454 (show subtarget assignments)	1	expressed	No	YPO0133	16120476	feoA	ferrous iron transport protein A	75	Virulence Associated Factor	Phase 2: March 2008	2GCX	70.7%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01309 (show subtarget assignments)	1	purified	No	VC2078	15642078		ferrous iron transport protein A	76	Drug Target Function	Phase 2: March 2008	2K5I	34.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP02586 (show subtarget assignments)	1	cloned	No	Cj1478c	15792793	cadF	fibronectin-binding protein [Campylobact...	319	Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...	Phase 3: June 2008	3NB3	24.5%	Campylobacter jejuni	Cell envelope	Other

IDP04264 (show subtarget assignments)	1	cloned	No	CPF_2101	110800507		fibronectin-binding protein [Clostridium...	575	conserved gene; putative drug target function;	Phase 4: April 2009	3DOA	17.7%	Clostridium perfringens	Cellular processes

IDP00036 (show subtarget assignments)	1	purified	No	BA_1840	30256110		fibronectin-binding protein, putative	213	Virulence	Phase 1: October 2007	2YB5	32.9%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP02418 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1279c	15792603		fibronectin domain-containing lipoprotei...	411	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	1QR4	10.9%	Campylobacter jejuni	Transcription	DNA-dependent RNA polymerase

IDP02582 (show subtarget assignments)	1	soluble	No	Cj1349c	15792672		fibronectin/fibrinogen-binding protein [...	435	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	3DOA	10.6%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00059 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4013	30258522		fibronectin/fibrinogen-binding protein, ...	569	Virulence	Phase 1: October 2007	3DOA	22.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP91694 (show subtarget assignments)	8	selected	No	NP_001989	51873055	FBLN2	fibulin-2 isoform b precursor [Homo sapi...	1184	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1N7D	8.7%	Homo sapiens

IDP01323 (show subtarget assignments)	1	cloned	No	VC2633	15642628		fimbrial assembly protein PilN, putative...	196	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Surface structures

IDP01472 (show subtarget assignments)	1	cloned	No	VC2631	15642626		fimbrial assembly protein PilP, putative...	172	Conserved Gene / Pathway	Phase 2: March 2008	2LC4	16.3%	Vibrio cholerae	Cell envelope	Surface structures

IDP01460 (show subtarget assignments)	1	cloned	No	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP01085 (show subtarget assignments)	1	in_crystallization_trials	No	STM4397	161353572	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans...	206	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP91061 (show subtarget assignments)	8	purified	No	YPO3532	16123678	fklB	FKBP-type peptidyl-prolyl cis-trans isom...	206	virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...	Community Requests	1FD9	38.8%	Yersinia pestis

IDP01022 (show subtarget assignments)	1	in_crystallization_trials	No	STM0048	16763438	slpA	FKBP-type peptidyl-prolyl cis-trans isom...	149	Conserved Gene / Pathway	Phase 2: March 2008	3PR9	29.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP05054 (show subtarget assignments)	1	cloned	No	CD0250	126697821	fliH	flagellar assembly protein [Clostridium ...	243	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02242 (show subtarget assignments)	1	cloned	No	Cj0320	15791688	fliH	flagellar assembly protein H [Campylobac...	276	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01603 (show subtarget assignments)	1	cloned	No	STM1971	16765309	fliH	flagellar assembly protein H [Salmonella...	235	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01716 (show subtarget assignments)	1	cloned	No	Cj0687c	15792036	flgH	flagellar basal body L-ring protein [Cam...	232	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00952 (show subtarget assignments)	1	purified	No	STM1176	16764532	flgD	flagellar basal body rod modification pr...	232	Conserved Gene / Pathway	Phase 2: March 2008	3C12	19.8%	Salmonella enterica	Cell envelope	Surface structures

IDP01884 (show subtarget assignments)	1	soluble	No	Cj0042	15791441	flgD	flagellar basal body rod modification pr...	294	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02680 (show subtarget assignments)	1	soluble	No	Cj0697	15792046	flgG2	flagellar basal-body rod protein [Campyl...	270	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP05287 (show subtarget assignments)	1	cloned	No	CD0245	126697816	flgB	flagellar basal-body rod protein [Clostr...	97	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP01714 (show subtarget assignments)	1	cloned	No	Cj0528c	15791889	flgB	flagellar basal body rod protein FlgB [C...	143	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP02754 (show subtarget assignments)	1	expressed	No	Cj0527c	15791888	flgC	flagellar basal body rod protein FlgC [C...	164	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP02695 (show subtarget assignments)	1	soluble	No	Cj0698	15792047	flgG	flagellar basal body rod protein FlgG [C...	263	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3A69	23.6%	Campylobacter jejuni	Unknown function	Enzymes of unknown specificity

IDP05729 (show subtarget assignments)	1	soluble	No	CD0263	126697835	flhA	flagellar biosynthesis protein FlhA [Clo...	691	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3MIX	22.6%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05131 (show subtarget assignments)	1	cloned	No	CD0260	126697832	fliP	flagellar biosynthesis protein FliP [Clo...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP01955 (show subtarget assignments)	1	cloned	No	STM1980	16765318	fliQ	flagellar biosynthesis protein FliQ [Sal...	89	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01664 (show subtarget assignments)	1	purified	No	Cj0064c	15791456	flhF	flagellar biosynthesis regulator FlhF [C...	484	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1ZU4	17.4%	Campylobacter jejuni	Cell envelope	Surface structures

IDP05133 (show subtarget assignments)	1	cloned	No	CD0264	126697836	flhF	flagellar biosynthesis regulator FlhF [C...	338	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J37	26%	Clostridium difficile	Protein fate: Protein and peptide secretion and trafficking

IDP02557 (show subtarget assignments)	1	purified	No	Cj0061c	15791453	fliA	flagellar biosynthesis sigma factor [Cam...	238	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1RP3	35.3%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP02248 (show subtarget assignments)	1	cloned	No	Cj0548	15791909	fliD	flagellar capping protein [Campylobacter...	642	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Protein synthesis	tRNA aminoacylation

IDP05495 (show subtarget assignments)	1	cloned	No	CD0237	126697808	fliD	flagellar cap protein [Clostridium diffi...	507	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05500 (show subtarget assignments)	1	cloned	No	CD0261	126697833	fliQ	flagellar export protein [Clostridium di...	89	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02354 (show subtarget assignments)	1	cloned	No	Cj0887c	15792217	flaD	flagellar hook-associated protein [Campy...	750	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	13.9%	Campylobacter jejuni	Cell envelope	Other

IDP05165
(show subtarget assignments)

1

soluble

No

BA_1888

30256549

enterotoxin [Bacillus anthracis str. Ame...

402

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NRJ

24.6%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP00647
(show subtarget assignments)

1

selected

No

SACOL1657

57286179

enterotoxin type A, putative

234

Virulence Associated Factor

Phase 2: March 2008

1ESF

40.2%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00272
(show subtarget assignments)

1

in_pdb
3EGP
3IRC

No

AF180817_281-775

7329982

N/A

Envelope (E)

495

Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...

Phase 1: October 2007

3G7T

78.8%

Dengue virus

N/A

IDP00280
(show subtarget assignments)

1

purified

No

AAX48017_51-545

604449

N/A

Envelope (E)

495

Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...

Phase 3: June 2008

3UAJ

79.2%

Dengue virus

N/A

IDP91731
(show subtarget assignments)

8

selected

No

NP_958854

41393583

EGFL7

epidermal growth factor-like protein 7 [...

273

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2W86

15.8%

Homo sapiens

IDP00629
(show subtarget assignments)

1

in_pdb
3QJG

No

SACOL1875

57284796

epiD

epidermin biosynthesis protein EpiD

172

Conserved Gene / Pathway

Phase 2: March 2008

3QJG

100%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00811
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1873

57284794

epiF

epidermin immunity protein F

230

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

33.6%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00624
(show subtarget assignments)

8

in_pdb
3T41
3QFH

No

SACOL1874

57284795

epiP

epidermin leader peptide processing seri...

457

Drug Target Function

Community Requests

3QFH

94.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP91545
(show subtarget assignments)

8

expressed

No

AAC78336

3892237

ereA2

erythromycin esterase [Providencia stuar...

408

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Providencia stuartii

IDP91544
(show subtarget assignments)

8

in_crystallization_trials

No

BAE54319

83627318

ereB

erythromycin esterase type II [Escherich...

419

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2QGM

25.8%

Escherichia coli

IDP90820
(show subtarget assignments)

8

in_pdb
3OET

No

STM2370

16765697

pdxB

erythronate-4-phosphate dehydrogenase [S...

378

Predicted Essential

Community Requests

3OET

100%

Salmonella enterica

IDP90773
(show subtarget assignments)

8

selected

No

VC2108

15642108

erythronate-4-phosphate dehydrogenase [V...

387

Predicted Essential

Community Requests

3OET

48.3%

Vibrio cholerae

IDP91610
(show subtarget assignments)

8

in_crystallization_trials

No

BAB37977

13364029

ECs4554

EspB protein [Escherichia coli O157:H7 s...

312

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP91616
(show subtarget assignments)

8

soluble

No

BAB36138

13362183

ECs2715

EspF-like protein [Escherichia coli O157...

337

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KXC

13.9%

Escherichia coli

IDP91577
(show subtarget assignments)

8

purified

No

BAB37973

13364025

ECs4550

EspF protein [Escherichia coli O157:H7 s...

248

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP05523
(show subtarget assignments)

1

soluble

No

CD2204

126699821

esterase [Clostridium difficile 630]

260

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2UZ0

33.5%

Clostridium difficile

Fatty acid and phospholipid metabolism: Degradation

IDP91527
(show subtarget assignments)

8

cloned

No

AAX13509

89214483

etpA

EtpA [Escherichia coli ETEC H10407]

1767

virulence/pathogenesis / The EtpA ETEC two-partner secretion (TPS) exoprotein [PMID: 16552055] is a highl...

Community Requests

3AK5

11.2%

Escherichia coli

IDP90294
(show subtarget assignments)

8

expressed

No

TGME49_113230

211962198

eukaryotic translation initiation factor...

347

Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...

Community Requests

1Q8K

40.3%

Toxoplasma gondii

IDP04218
(show subtarget assignments)

1

expressed

No

STM2996_1_1123

16766298

recC

exonuclease V subunit gamma [Salmonella ...

1123

Salmonella essential protein

Phase 4: April 2009

1W36

88.4%

Salmonella enterica

IDP02550
(show subtarget assignments)

1

in_pdb
3RF0

Yes

YPO2837

16123032

ppx

exopolyphosphatase [Yersinia pestis CO92...

519

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1U6Z

76.3%

Yersinia pestis

Central intermediary metabolism

Phosphorus compounds

IDP00131
(show subtarget assignments)

0

work_stopped

No

NT01ST2113

16765046

rnb

exoribonuclease II

644

Essential

Phase 1: October 2007

2ID0

90.7%

Salmonella enterica

Transcription

Degradation of RNA

IDP05644
(show subtarget assignments)

1

cloned

No

CD3230

126700850

bclA2

exosporium glycoprotein [Clostridium dif...

558

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

35.3%

Clostridium difficile

Unclassified: Role category not yet assigned

IDP91634
(show subtarget assignments)

8

selected

No

AAC16023

2429143

exoU

ExoU [Pseudomonas aeruginosa]

687

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

4AKX

95.8%

Pseudomonas aeruginosa

IDP02717
(show subtarget assignments)

1

cloned

No

GBAA3854

47529142

chi36

extracellular exochitinase Chi36 [Bacill...

360

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N11

88.6%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP91953
(show subtarget assignments)

8

cloned

No

SpneCM_010100002215

298254414

extracellular solute-binding lipoprotein...

442

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QUF

20.6%

Streptococcus pneumoniae

IDP04240
(show subtarget assignments)

1

cloned

No

CPF_1077

110800997

extracellular solute-binding protein [Cl...

477

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W7Y

15.3%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04378
(show subtarget assignments)

1

cloned

No

CPF_2335

110799804

extracellular solute-binding protein [Cl...

482

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP01699
(show subtarget assignments)

1

purified

No

YPO3343

16123493

extracellular solute-binding protein [Ye...

256

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3KBR

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP91702
(show subtarget assignments)

8

selected

No

NP_003370

21614499

EZR

ezrin [Homo sapiens]

586

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2I1J

56.9%

Homo sapiens

IDP01821
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5549

47530869

atpA

F0F1 ATP synthase subunit alpha [Bacillu...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

84.5%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP01802
(show subtarget assignments)

1

crystallized

No

FTT0062

56707241

atpA

F0F1 ATP synthase subunit alpha [Francis...

513

Conserved; Drug target functions

Phase 3: June 2008

3OAA

71%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02711
(show subtarget assignments)

1

cloned

No

GBAA5551

47530871

atpF

F0F1 ATP synthase subunit B [Bacillus an...

168

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP01832
(show subtarget assignments)

1

expressed

No

GBAA5547

47530867

atpD

F0F1 ATP synthase subunit beta [Bacillus...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

86.4%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02648
(show subtarget assignments)

1

soluble

No

FTT0064

56707243

atpD

F0F1 ATP synthase subunit beta [Francise...

458

Conserved; Drug target functions

Phase 3: June 2008

3OAA

81.3%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP01933
(show subtarget assignments)

1

soluble

No

FTT0061

56707240

atpH

F0F1 ATP synthase subunit delta [Francis...

174

Conserved; Drug target functions

Phase 3: June 2008

2WSS

28.2%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02577
(show subtarget assignments)

1

purified

No

GBAA5546

47530866

atpC

F0F1 ATP synthase subunit epsilon [Bacil...

133

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E5Y

69.9%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02182
(show subtarget assignments)

1

cloned

No

FTT0065

56707244

atpC

F0F1 ATP synthase subunit epsilon [Franc...

145

Conserved; Drug target functions

Phase 3: June 2008

2QE7

33.1%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP01863
(show subtarget assignments)

1

cloned

No

GBAA5548

47778410

atpG

F0F1 ATP synthase subunit gamma [Bacillu...

286

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QE7

58.7%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02177
(show subtarget assignments)

1

soluble

No

FTT0063

56707242

atpG

F0F1 ATP synthase subunit gamma [Francis...

298

Conserved; Drug target functions

Phase 3: June 2008

3OAA

49.7%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP91252
(show subtarget assignments)

8

soluble

No

NT01LM1948

16411261

fabG

fabG [Listeria monocytogenes]

247

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2UVD

66.4%

Listeria monocytogenes

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90343
(show subtarget assignments)

8

expressed

No

CT148

15604867

mhpA

FAD-dependent monooxygenase [Chlamydia t...

507

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP92553
(show subtarget assignments)

8

selected

No

VV1_2233

27361706

fadR

fatty acid metabolism transcriptional re...

279

potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...

Community Requests

1E2X

52%

Vibrio vulnificus

IDP00955
(show subtarget assignments)

1

cloned

No

STM1192

16764547

plsX

fatty acid/phospholipid synthesis protei...

359

Conserved Gene / Pathway

Phase 2: March 2008

1U7N

36.5%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04082
(show subtarget assignments)

1

cloned

No

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04410
(show subtarget assignments)

1

cloned

No

VC1047

9655512

fatty oxidation complex, alpha subunit [...

724

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1WDK

36.4%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP00108
(show subtarget assignments)

1

purified

No

NT01SF4751

30043076

fdhE

FdhE protein

309

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FIY

39.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00822
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2253

57285032

femX

femX protein

421

Conserved Gene / Pathway

Phase 2: March 2008

1LRZ

26.7%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01812
(show subtarget assignments)

1

cloned

No

FTT1764c

56708759

ferredoxin [Francisella tularensis subsp...

107

Conserved; Drug target functions

Phase 3: June 2008

1A6L

64.5%

Francisella tularensis

Energy metabolism

Electron transport

IDP01074
(show subtarget assignments)

1

in_pdb
3FPK

Yes

STM4084

16767350

fpr

ferredoxin-NADP reductase

248

Conserved Gene / Pathway

Phase 2: March 2008

3FPK

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP91439
(show subtarget assignments)

8

cloned

No

VV1_0471

27363938

ferredoxin [Vibrio vulnificus CMCP6]

84

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2ZVS

65.5%

Vibrio vulnificus

IDP00911
(show subtarget assignments)

1

expressed

No

STM0191

16763581

fhuA

ferrichrome outer membrane transporter

729

Conserved Gene / Pathway

Phase 2: March 2008

2FCP

72.3%

Salmonella enterica

Cell envelope

Other

IDP91017
(show subtarget assignments)

8

expressed

No

y2556

22126437

fcuA

ferrichrome receptor, TonB dependent [Ye...

776

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

3QLB

23.6%

Yersinia pestis

IDP01341
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0687

15601444

fbpC

ferric transporter ATP-binding subunit

351

Conserved Gene / Pathway

Phase 2: March 2008

1V43

38.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01129
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5296

30259774

ferritin

168

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

48.2%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01358
(show subtarget assignments)

1

in_pdb
3QZ3

Yes

VC0078

15640110

ferritin

181

Conserved Gene / Pathway

Phase 2: March 2008

3QZ3

100%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00977
(show subtarget assignments)

1

expressed

No

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00611
(show subtarget assignments)

1

crystallized

No

SACOL1952

57286299

ferritins family protein

166

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

39.2%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP02347
(show subtarget assignments)

1

soluble

No

YPO1783

16122037

ftnA

ferritin [Yersinia pestis CO92]

169

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QZ3

68.6%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00092
(show subtarget assignments)

1

expressed

No

NT01SF0466

30040219

hemH

ferrochelatase

320

Essential

Phase 1: October 2007

1L8X

27.9%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04666
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1158

47526425

hemH-2

ferrochelatase [Bacillus anthracis str. ...

319

putative drug target function;

Phase 4: April 2009

2C8J

62.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90719
(show subtarget assignments)

8

soluble

No

Cj0503c

15791865

hemH

ferrochelatase [Campylobacter jejuni sub...

303

Predicted Essential

Community Requests

2PO7

31%

Campylobacter jejuni

IDP02423
(show subtarget assignments)

1

cloned

No

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90812
(show subtarget assignments)

8

soluble

No

YPO3117

16123282

hemH

ferrochelatase [Yersinia pestis CO92]

320

Predicted Essential

Community Requests

2QD2

26.2%

Yersinia pestis

IDP00454
(show subtarget assignments)

1

expressed

No

YPO0133

16120476

feoA

ferrous iron transport protein A

75

Virulence Associated Factor

Phase 2: March 2008

2GCX

70.7%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01309
(show subtarget assignments)

1

purified

No

VC2078

15642078

ferrous iron transport protein A

76

Drug Target Function

Phase 2: March 2008

2K5I

34.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP02586
(show subtarget assignments)

1

cloned

No

Cj1478c

15792793

cadF

fibronectin-binding protein [Campylobact...

319

Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...

Phase 3: June 2008

3NB3

24.5%

Campylobacter jejuni

Cell envelope

Other

IDP04264
(show subtarget assignments)

1

cloned

No

CPF_2101

110800507

fibronectin-binding protein [Clostridium...

575

conserved gene; putative drug target function;

Phase 4: April 2009

3DOA

17.7%

Clostridium perfringens

Cellular processes

IDP00036
(show subtarget assignments)

1

purified

No

BA_1840

30256110

fibronectin-binding protein, putative

213

Virulence

Phase 1: October 2007

2YB5

32.9%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP02418
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1279c

15792603

fibronectin domain-containing lipoprotei...

411

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

1QR4

10.9%

Campylobacter jejuni

Transcription

DNA-dependent RNA polymerase

IDP02582
(show subtarget assignments)

1

soluble

No

Cj1349c

15792672

fibronectin/fibrinogen-binding protein [...

435

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

3DOA

10.6%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00059
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4013

30258522

fibronectin/fibrinogen-binding protein, ...

569

Virulence

Phase 1: October 2007

3DOA

22.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP91694
(show subtarget assignments)

8

selected

No

NP_001989

51873055

FBLN2

fibulin-2 isoform b precursor [Homo sapi...

1184

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1N7D

8.7%

Homo sapiens

IDP01323
(show subtarget assignments)

1

cloned

No

VC2633

15642628

fimbrial assembly protein PilN, putative...

196

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Surface structures

IDP01472
(show subtarget assignments)

1

cloned

No

VC2631

15642626

fimbrial assembly protein PilP, putative...

172

Conserved Gene / Pathway

Phase 2: March 2008

2LC4

16.3%

Vibrio cholerae

Cell envelope

Surface structures

IDP01460
(show subtarget assignments)

1

cloned

No

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP01085
(show subtarget assignments)

1

in_crystallization_trials

No

STM4397

161353572

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans...

206

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP91061
(show subtarget assignments)

8

purified

No

YPO3532

16123678

fklB

FKBP-type peptidyl-prolyl cis-trans isom...

206

virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...

Community Requests

1FD9

38.8%

Yersinia pestis

IDP01022
(show subtarget assignments)

1

in_crystallization_trials

No

STM0048

16763438

slpA

FKBP-type peptidyl-prolyl cis-trans isom...

149

Conserved Gene / Pathway

Phase 2: March 2008

3PR9

29.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP05054
(show subtarget assignments)

1

cloned

No

CD0250

126697821

fliH

flagellar assembly protein [Clostridium ...

243

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02242
(show subtarget assignments)

1

cloned

No

Cj0320

15791688

fliH

flagellar assembly protein H [Campylobac...

276

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01603
(show subtarget assignments)

1

cloned

No

STM1971

16765309

fliH

flagellar assembly protein H [Salmonella...

235

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01716
(show subtarget assignments)

1

cloned

No

Cj0687c

15792036

flgH

flagellar basal body L-ring protein [Cam...

232

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00952
(show subtarget assignments)

1

purified

No

STM1176

16764532

flgD

flagellar basal body rod modification pr...

232

Conserved Gene / Pathway

Phase 2: March 2008

3C12

19.8%

Salmonella enterica

Cell envelope

Surface structures

IDP01884
(show subtarget assignments)

1

soluble

No

Cj0042

15791441

flgD

flagellar basal body rod modification pr...

294

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02680
(show subtarget assignments)

1

soluble

No

Cj0697

15792046

flgG2

flagellar basal-body rod protein [Campyl...

270

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP05287
(show subtarget assignments)

1

cloned

No

CD0245

126697816

flgB

flagellar basal-body rod protein [Clostr...

97

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP01714
(show subtarget assignments)

1

cloned

No

Cj0528c

15791889

flgB

flagellar basal body rod protein FlgB [C...

143

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP02754
(show subtarget assignments)

1

expressed

No

Cj0527c

15791888

flgC

flagellar basal body rod protein FlgC [C...

164

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP02695
(show subtarget assignments)

1

soluble

No

Cj0698

15792047

flgG

flagellar basal body rod protein FlgG [C...

263

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3A69

23.6%

Campylobacter jejuni

Unknown function

Enzymes of unknown specificity

IDP05729
(show subtarget assignments)

1

soluble

No

CD0263

126697835

flhA

flagellar biosynthesis protein FlhA [Clo...

691

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3MIX

22.6%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05131
(show subtarget assignments)

1

cloned

No

CD0260

126697832

fliP

flagellar biosynthesis protein FliP [Clo...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP01955
(show subtarget assignments)

1

cloned

No

STM1980

16765318

fliQ

flagellar biosynthesis protein FliQ [Sal...

89

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01664
(show subtarget assignments)

1

purified

No

Cj0064c

15791456

flhF

flagellar biosynthesis regulator FlhF [C...

484

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1ZU4

17.4%

Campylobacter jejuni

Cell envelope

Surface structures

IDP05133
(show subtarget assignments)

1

cloned

No

CD0264

126697836

flhF

flagellar biosynthesis regulator FlhF [C...

338

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J37

26%

Clostridium difficile

Protein fate: Protein and peptide secretion and trafficking

IDP02557
(show subtarget assignments)

1

purified

No

Cj0061c

15791453

fliA

flagellar biosynthesis sigma factor [Cam...

238

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1RP3

35.3%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP02248
(show subtarget assignments)

1

cloned

No

Cj0548

15791909

fliD

flagellar capping protein [Campylobacter...

642

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Protein synthesis

tRNA aminoacylation

IDP05495
(show subtarget assignments)

1

cloned

No

CD0237

126697808

fliD

flagellar cap protein [Clostridium diffi...

507

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05500
(show subtarget assignments)

1

cloned

No

CD0261

126697833

fliQ

flagellar export protein [Clostridium di...

89

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02354
(show subtarget assignments)

1

cloned

No

Cj0887c

15792217

flaD

flagellar hook-associated protein [Campy...

750

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

13.9%

Campylobacter jejuni

Cell envelope

Other