Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04052 (show subtarget assignments)	1	cloned	No	CPF_0049	110799596		putative lipoprotein [Clostridium perfri...	167	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04382 (show subtarget assignments)	1	expressed	No	CPF_0116	110801065		sensor histidine kinase [Clostridium per...	337	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17.8%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04226 (show subtarget assignments)	1	cloned	No	CPF_0171	110799571	luxS	S-ribosylhomocysteinase [Clostridium per...	151	conserved gene; putative drug target function;	Phase 4: April 2009	1J6W	51%	Clostridium perfringens	Cellular processes	Other

IDP04227 (show subtarget assignments)	1	expressed	No	CPF_0198	110799765		sensory box histidine kinase [Clostridiu...	791	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.6%	Clostridium perfringens	Regulatory functions

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04189 (show subtarget assignments)	1	expressed	No	CPF_0225	110799110		sensor histidine kinase [Clostridium per...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04200 (show subtarget assignments)	1	expressed	No	CPF_0244	110798897		putative lipoprotein [Clostridium perfri...	440	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04303 (show subtarget assignments)	1	cloned	No	CPF_0251	110800905	lacA	galactoside O-acetyltransferase [Clostri...	204	conserved gene; putative drug target function;	Phase 4: April 2009	1KQA	51%	Clostridium perfringens	Cellular processes	Detoxification

IDP04042 (show subtarget assignments)	1	cloned	No	CPF_0296	110798725		putative cell division ATP-binding prote...	228	conserved gene; putative drug target function;	Phase 4: April 2009	1F3O	40.6%	Clostridium perfringens	Cellular processes	Cell division

IDP04549 (show subtarget assignments)	1	cloned	No	CPF_0346	110800626		putative lioprotein [Clostridium perfrin...	184	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04508 (show subtarget assignments)	1	cloned	No	CPF_0372	110799482		polysaccharide deacetylase family protei...	306	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NY1	17.6%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04412 (show subtarget assignments)	1	cloned	No	CPF_0435	110799959		putative lipoprotein [Clostridium perfri...	431	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04509 (show subtarget assignments)	1	selected	No	CPF_0440	110800446		iron compound ABC transporter, iron comp...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PT1	37.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04201 (show subtarget assignments)	1	expressed	No	CPF_0499	110800753		sensor histidine kinase [Clostridium per...	431	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04540 (show subtarget assignments)	1	purified	No	CPF_0511	110801291		sensor histidine kinase [Clostridium per...	516	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	18.2%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04063 (show subtarget assignments)	1	cloned	No	CPF_0514	110800714		putative lipoprotein [Clostridium perfri...	176	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04190 (show subtarget assignments)	1	cloned	No	CPF_0544	110800679	spoVD	stage V sporulation protein D [Clostridi...	721	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	27.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04191 (show subtarget assignments)	1	expressed	No	CPF_0554	110800843		sensor histidine kinase [Clostridium per...	583	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04058 (show subtarget assignments)	1	soluble	No	CPF_0556	110800185		ABC transporter, solute-binding protein ...	461	drug target; putative drug target function;	Phase 4: April 2009	1EU8	18.9%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04403 (show subtarget assignments)	1	cloned	No	CPF_0630	110801303		spore germination protein [Clostridium p...	374	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N54	17.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04192 (show subtarget assignments)	1	cloned	No	CPF_0671	110799768		phosphoribosylformylglycinamidine syntha...	1266	conserved gene; putative drug target function;	Phase 4: April 2009	3AC6	15.2%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04300 (show subtarget assignments)	1	purified	No	CPF_0672	110798984	purE	phosphoribosylaminoimidazole carboxylase...	159	conserved gene; putative drug target function;	Phase 4: April 2009	1O4V	51.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04560 (show subtarget assignments)	1	in_pdb 3NUA	Yes	CPF_0673	110799762	purC	phosphoribosylaminoimidazole-succinocarb...	235	conserved gene; putative drug target function;	Phase 4: April 2009	3NUA	100%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04228 (show subtarget assignments)	1	cloned	No	CPF_0675	110800755	purM	phosphoribosylaminoimidazole synthetase ...	333	conserved gene; putative drug target function;	Phase 4: April 2009	2BTU	54.9%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04229 (show subtarget assignments)	1	purified	No	CPF_0676	110798651	purN	phosphoribosylglycinamide formyltransfer...	204	conserved gene; putative drug target function;	Phase 4: April 2009	2YWR	42.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04407 (show subtarget assignments)	1	cloned	No	CPF_0677	110799553	purH	bifunctional phosphoribosylaminoimidazol...	501	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	41.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04230 (show subtarget assignments)	1	purified	No	CPF_0678	110801134	purD	phosphoribosylamine--glycine ligase [Clo...	416	conserved gene; putative drug target function;	Phase 4: April 2009	2YW2	51.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04232 (show subtarget assignments)	1	cloned	No	CPF_0693	110799915	aroE	shikimate 5-dehydrogenase [Clostridium p...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3FBT	46.9%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04090 (show subtarget assignments)	1	crystallized	No	CPF_0694	110800453	aroK	shikimate kinase [Clostridium perfringen...	167	conserved gene; putative drug target function;	Phase 4: April 2009	2PT5	34.1%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04337 (show subtarget assignments)	1	cloned	No	CPF_0720	110801161	splB	spore photoproduct lyase [Clostridium pe...	340	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04233 (show subtarget assignments)	1	cloned	No	CPF_0722	110798767		putative lipoprotein [Clostridium perfri...	384	drug target; putative drug target function;	Phase 4: April 2009	2UVK	16.1%	Clostridium perfringens	Cell envelope	Other

IDP04234 (show subtarget assignments)	1	cloned	No	CPF_0807	110799166		iron compound ABC transporter, iron comp...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HXP	29.3%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04235 (show subtarget assignments)	1	cloned	No	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04016 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0834	110798754	arsC	arsenate reductase ArsC [Clostridium per...	132	conserved gene; putative drug target function;	Phase 4: April 2009	2L17	40.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04236 (show subtarget assignments)	1	expressed	No	CPF_0837	110799475		sensor histidine kinase [Clostridium per...	336	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04237 (show subtarget assignments)	1	purified	No	CPF_0863	110800564		putative sensor histidine kinase [Clostr...	420	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04238 (show subtarget assignments)	1	cloned	No	CPF_0889	110799788		sensor histidine kinase [Clostridium per...	475	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04017 (show subtarget assignments)	1	cloned	No	CPF_1035	110799411		putative lipoprotein [Clostridium perfri...	309	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04239 (show subtarget assignments)	1	cloned	No	CPF_1057	110799811		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.4%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04391 (show subtarget assignments)	1	cloned	No	CPF_1067	110798883	cotJB	spore coat protein CotJB [Clostridium pe...	83	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04040 (show subtarget assignments)	1	cloned	No	CPF_1068	110800949	cotJC	spore coat protein CotJC [Clostridium pe...	188	conserved gene; putative drug target function;	Phase 4: April 2009	1JKU	34.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04240 (show subtarget assignments)	1	cloned	No	CPF_1077	110800997		extracellular solute-binding protein [Cl...	477	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W7Y	15.3%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04562 (show subtarget assignments)	1	cloned	No	CPF_1080	110798737		putative lipoprotein [Clostridium perfri...	185	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04241 (show subtarget assignments)	1	soluble	No	CPF_1112	110801022		sensor histidine kinase [Clostridium per...	574	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Regulatory functions	Protein interactions

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04243 (show subtarget assignments)	1	soluble	No	CPF_1140	110799522		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04244 (show subtarget assignments)	1	soluble	No	CPF_1171	110801284		sensor histidine kinase [Clostridium per...	410	conserved gene; putative drug target function;	Phase 4: April 2009	1B3Q	9.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04245 (show subtarget assignments)	1	cloned	No	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04133 (show subtarget assignments)	1	cloned	No	CPF_1195	110798868	hpkA	sensor histidine kinase [Clostridium per...	287	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	25.8%	Clostridium perfringens	Regulatory functions	Other

IDP04545 (show subtarget assignments)	1	purified	No	CPF_1198	110801283		glutathione peroxidase [Clostridium perf...	178	drug target; putative drug target function;	Phase 4: April 2009	3CMI	48.3%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP04351 (show subtarget assignments)	1	cloned	No	CPF_1213	110799898	kdpD	sensor histidine kinase KdpD [Clostridiu...	900	conserved gene; putative drug target function;	Phase 4: April 2009	2R8R	12.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP04091 (show subtarget assignments)	1	cloned	No	CPF_1278	110799680		putative lipoprotein [Clostridium perfri...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04004 (show subtarget assignments)	1	cloned	No	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP04006 (show subtarget assignments)	1	cloned	No	CPF_1351	110800739		putative lipoprotein [Clostridium perfri...	264	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04247 (show subtarget assignments)	1	expressed	No	CPF_1402	110798994		sensor histidine kinase [Clostridium per...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.3%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04408 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_1426	110798602		iron(III) ABC transporter, iron(III)-bin...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GFV	24.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04338 (show subtarget assignments)	1	cloned	No	CPF_1446	110801179	sodF	Mn/Fe superoxide dismutase [Clostridium ...	227	conserved gene; putative drug target function;	Phase 4: April 2009	1JR9	44.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP91551 (show subtarget assignments)	8	cloned	No	CPF_1456	110799663		hypothetical protein CPF_1456 [Clostridi...	851	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Clostridium perfringens

IDP04329 (show subtarget assignments)	1	expressed	No	CPF_1466	110801108		putative lipoprotein [Clostridium perfri...	483	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04248 (show subtarget assignments)	1	in_pdb 4EDP	No	CPF_1477	110800354		ABC transporter, substrate-binding prote...	348	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EDP	100%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04392 (show subtarget assignments)	1	cloned	No	CPF_1500	110798925		putative lipoprotein [Clostridium perfri...	202	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04365 (show subtarget assignments)	1	cloned	No	CPF_1523	110798905		sensory box histidine kinase [Clostridiu...	787	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	11.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04366 (show subtarget assignments)	1	purified	No	CPF_1531	110800274		amino acid ABC transporter, amino acid-b...	262	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HV1	36.6%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04249 (show subtarget assignments)	1	expressed	No	CPF_1548	110800969		putative galactoside ABC transporter, ga...	354	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GLG	50.6%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04564 (show subtarget assignments)	1	cloned	No	CPF_1610	110800230		putative lipoprotein [Clostridium perfri...	125	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04393 (show subtarget assignments)	1	cloned	No	CPF_1645	110798596	lonB	ATP-dependent protease LonB [Clostridium...	570	conserved gene; putative drug target function;	Phase 4: April 2009	3K1J	29.4%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04251 (show subtarget assignments)	1	cloned	No	CPF_1751	110801372	virS	sensor histidine kinase VirS [Clostridiu...	440	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP91082 (show subtarget assignments)	8	cloned	No	CPF_1776	110800219		ABC transporter, permease/ATP-binding pr...	589	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	39.2%	Clostridium perfringens

IDP04252 (show subtarget assignments)	1	cloned	No	CPF_1780	110799805		putative lipoprotein [Clostridium perfri...	445	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04253 (show subtarget assignments)	1	purified	No	CPF_1800	110800480	prs	phosphoribosylpyrophosphate synthetase [...	364	conserved gene; putative drug target function;	Phase 4: April 2009	2C4K	25.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04565 (show subtarget assignments)	1	cloned	No	CPF_1805	110798813		putative lipoprotein [Clostridium perfri...	281	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04307 (show subtarget assignments)	1	cloned	No	CPF_1812	110799901		putative lipoprotein [Clostridium perfri...	44	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens

IDP04254 (show subtarget assignments)	1	cloned	No	CPF_1823	110798846		putative lipoprotein [Clostridium perfri...	233	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP91550 (show subtarget assignments)	8	purified	No	CPF_1845	110799546		FmtC domain-containing protein [Clostrid...	395	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Clostridium perfringens

IDP91549 (show subtarget assignments)	8	cloned	No	CPF_1846	110800166		hypothetical protein CPF_1846 [Clostridi...	159	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Clostridium perfringens

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04566 (show subtarget assignments)	1	expressed	No	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04092 (show subtarget assignments)	1	cloned	No	CPF_1925	110801017	spoVS	stage V sporulation protein S [Clostridi...	86	conserved gene; putative drug target function;	Phase 4: April 2009	2EH1	57%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04036 (show subtarget assignments)	1	cloned	No	CPF_1970	110800938	smc	chromosome segregation protein SMC [Clos...	1185	conserved gene; putative drug target function;	Phase 4: April 2009	3AUX	8.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04256 (show subtarget assignments)	1	purified	No	CPF_2006	110801043	spoIVA	stage IV sporulation protein A [Clostrid...	491	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP04258 (show subtarget assignments)	1	soluble	No	CPF_2010	110801347		sensory box histidine kinase [Clostridiu...	571	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	17.3%	Clostridium perfringens	Regulatory functions

IDP04259 (show subtarget assignments)	1	cloned	No	CPF_2018	110799691	ftsZ	cell division protein FtsZ [Clostridium ...	381	conserved gene; putative drug target function;	Phase 4: April 2009	2VAM	58%	Clostridium perfringens	Cellular processes	Cell division

IDP04260 (show subtarget assignments)	1	cloned	No	CPF_2020	110798885	pilT	twitching motility protein PilT [Clostri...	350	conserved gene; putative drug target function;	Phase 4: April 2009	2EWV	49.1%	Clostridium perfringens	Cellular processes	Chemotaxis and motility

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04262 (show subtarget assignments)	1	cloned	No	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04263 (show subtarget assignments)	1	cloned	No	CPF_2068	110800995		stage IV sporulation protein B [Clostrid...	386	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04727 (show subtarget assignments)	1	purified	No	CPF_2072	110800396		hemolysin A [Clostridium perfringens ATC...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3HP7	49.8%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04019 (show subtarget assignments)	1	cloned	No	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009	3TUF	24.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04052
(show subtarget assignments)

1

cloned

No

CPF_0049

110799596

putative lipoprotein [Clostridium perfri...

167

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04382
(show subtarget assignments)

1

expressed

No

CPF_0116

110801065

sensor histidine kinase [Clostridium per...

337

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17.8%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04226
(show subtarget assignments)

1

cloned

No

CPF_0171

110799571

luxS

S-ribosylhomocysteinase [Clostridium per...

151

conserved gene; putative drug target function;

Phase 4: April 2009

1J6W

51%

Clostridium perfringens

Cellular processes

Other

IDP04227
(show subtarget assignments)

1

expressed

No

CPF_0198

110799765

sensory box histidine kinase [Clostridiu...

791

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.6%

Clostridium perfringens

Regulatory functions

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04189
(show subtarget assignments)

1

expressed

No

CPF_0225

110799110

sensor histidine kinase [Clostridium per...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04200
(show subtarget assignments)

1

expressed

No

CPF_0244

110798897

putative lipoprotein [Clostridium perfri...

440

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04303
(show subtarget assignments)

1

cloned

No

CPF_0251

110800905

lacA

galactoside O-acetyltransferase [Clostri...

204

conserved gene; putative drug target function;

Phase 4: April 2009

1KQA

51%

Clostridium perfringens

Cellular processes

Detoxification

IDP04042
(show subtarget assignments)

1

cloned

No

CPF_0296

110798725

putative cell division ATP-binding prote...

228

conserved gene; putative drug target function;

Phase 4: April 2009

1F3O

40.6%

Clostridium perfringens

Cellular processes

Cell division

IDP04549
(show subtarget assignments)

1

cloned

No

CPF_0346

110800626

putative lioprotein [Clostridium perfrin...

184

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04508
(show subtarget assignments)

1

cloned

No

CPF_0372

110799482

polysaccharide deacetylase family protei...

306

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NY1

17.6%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04412
(show subtarget assignments)

1

cloned

No

CPF_0435

110799959

putative lipoprotein [Clostridium perfri...

431

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04509
(show subtarget assignments)

1

selected

No

CPF_0440

110800446

iron compound ABC transporter, iron comp...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PT1

37.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04201
(show subtarget assignments)

1

expressed

No

CPF_0499

110800753

sensor histidine kinase [Clostridium per...

431

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04540
(show subtarget assignments)

1

purified

No

CPF_0511

110801291

sensor histidine kinase [Clostridium per...

516

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

18.2%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04063
(show subtarget assignments)

1

cloned

No

CPF_0514

110800714

putative lipoprotein [Clostridium perfri...

176

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04190
(show subtarget assignments)

1

cloned

No

CPF_0544

110800679

spoVD

stage V sporulation protein D [Clostridi...

721

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

27.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04191
(show subtarget assignments)

1

expressed

No

CPF_0554

110800843

sensor histidine kinase [Clostridium per...

583

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04058
(show subtarget assignments)

1

soluble

No

CPF_0556

110800185

ABC transporter, solute-binding protein ...

461

drug target; putative drug target function;

Phase 4: April 2009

1EU8

18.9%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04403
(show subtarget assignments)

1

cloned

No

CPF_0630

110801303

spore germination protein [Clostridium p...

374

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N54

17.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04192
(show subtarget assignments)

1

cloned

No

CPF_0671

110799768

phosphoribosylformylglycinamidine syntha...

1266

conserved gene; putative drug target function;

Phase 4: April 2009

3AC6

15.2%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04300
(show subtarget assignments)

1

purified

No

CPF_0672

110798984

purE

phosphoribosylaminoimidazole carboxylase...

159

conserved gene; putative drug target function;

Phase 4: April 2009

1O4V

51.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04560
(show subtarget assignments)

1

in_pdb
3NUA

Yes

CPF_0673

110799762

purC

phosphoribosylaminoimidazole-succinocarb...

235

conserved gene; putative drug target function;

Phase 4: April 2009

3NUA

100%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04228
(show subtarget assignments)

1

cloned

No

CPF_0675

110800755

purM

phosphoribosylaminoimidazole synthetase ...

333

conserved gene; putative drug target function;

Phase 4: April 2009

2BTU

54.9%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04229
(show subtarget assignments)

1

purified

No

CPF_0676

110798651

purN

phosphoribosylglycinamide formyltransfer...

204

conserved gene; putative drug target function;

Phase 4: April 2009

2YWR

42.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04407
(show subtarget assignments)

1

cloned

No

CPF_0677

110799553

purH

bifunctional phosphoribosylaminoimidazol...

501

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

41.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04230
(show subtarget assignments)

1

purified

No

CPF_0678

110801134

purD

phosphoribosylamine--glycine ligase [Clo...

416

conserved gene; putative drug target function;

Phase 4: April 2009

2YW2

51.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04232
(show subtarget assignments)

1

cloned

No

CPF_0693

110799915

aroE

shikimate 5-dehydrogenase [Clostridium p...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3FBT

46.9%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04090
(show subtarget assignments)

1

crystallized

No

CPF_0694

110800453

aroK

shikimate kinase [Clostridium perfringen...

167

conserved gene; putative drug target function;

Phase 4: April 2009

2PT5

34.1%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04337
(show subtarget assignments)

1

cloned

No

CPF_0720

110801161

splB

spore photoproduct lyase [Clostridium pe...

340

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04233
(show subtarget assignments)

1

cloned

No

CPF_0722

110798767

putative lipoprotein [Clostridium perfri...

384

drug target; putative drug target function;

Phase 4: April 2009

2UVK

16.1%

Clostridium perfringens

Cell envelope

Other

IDP04234
(show subtarget assignments)

1

cloned

No

CPF_0807

110799166

iron compound ABC transporter, iron comp...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HXP

29.3%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04235
(show subtarget assignments)

1

cloned

No

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04016
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0834

110798754

arsC

arsenate reductase ArsC [Clostridium per...

132

conserved gene; putative drug target function;

Phase 4: April 2009

2L17

40.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04236
(show subtarget assignments)

1

expressed

No

CPF_0837

110799475

sensor histidine kinase [Clostridium per...

336

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04237
(show subtarget assignments)

1

purified

No

CPF_0863

110800564

putative sensor histidine kinase [Clostr...

420

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04238
(show subtarget assignments)

1

cloned

No

CPF_0889

110799788

sensor histidine kinase [Clostridium per...

475

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04017
(show subtarget assignments)

1

cloned

No

CPF_1035

110799411

putative lipoprotein [Clostridium perfri...

309

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04239
(show subtarget assignments)

1

cloned

No

CPF_1057

110799811

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.4%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04391
(show subtarget assignments)

1

cloned

No

CPF_1067

110798883

cotJB

spore coat protein CotJB [Clostridium pe...

83

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04040
(show subtarget assignments)

1

cloned

No

CPF_1068

110800949

cotJC

spore coat protein CotJC [Clostridium pe...

188

conserved gene; putative drug target function;

Phase 4: April 2009

1JKU

34.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04240
(show subtarget assignments)

1

cloned

No

CPF_1077

110800997

extracellular solute-binding protein [Cl...

477

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W7Y

15.3%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04562
(show subtarget assignments)

1

cloned

No

CPF_1080

110798737

putative lipoprotein [Clostridium perfri...

185

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04241
(show subtarget assignments)

1

soluble

No

CPF_1112

110801022

sensor histidine kinase [Clostridium per...

574

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04243
(show subtarget assignments)

1

soluble

No

CPF_1140

110799522

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04244
(show subtarget assignments)

1

soluble

No

CPF_1171

110801284

sensor histidine kinase [Clostridium per...

410

conserved gene; putative drug target function;

Phase 4: April 2009

1B3Q

9.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04245
(show subtarget assignments)

1

cloned

No

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04133
(show subtarget assignments)

1

cloned

No

CPF_1195

110798868

hpkA

sensor histidine kinase [Clostridium per...

287

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

25.8%

Clostridium perfringens

Regulatory functions

Other

IDP04545
(show subtarget assignments)

1

purified

No

CPF_1198

110801283

glutathione peroxidase [Clostridium perf...

178

drug target; putative drug target function;

Phase 4: April 2009

3CMI

48.3%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP04351
(show subtarget assignments)

1

cloned

No

CPF_1213

110799898

kdpD

sensor histidine kinase KdpD [Clostridiu...

900

conserved gene; putative drug target function;

Phase 4: April 2009

2R8R

12.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP04091
(show subtarget assignments)

1

cloned

No

CPF_1278

110799680

putative lipoprotein [Clostridium perfri...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04004
(show subtarget assignments)

1

cloned

No

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP04006
(show subtarget assignments)

1

cloned

No

CPF_1351

110800739

putative lipoprotein [Clostridium perfri...

264

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04247
(show subtarget assignments)

1

expressed

No

CPF_1402

110798994

sensor histidine kinase [Clostridium per...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.3%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04408
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_1426

110798602

iron(III) ABC transporter, iron(III)-bin...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GFV

24.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04338
(show subtarget assignments)

1

cloned

No

CPF_1446

110801179

sodF

Mn/Fe superoxide dismutase [Clostridium ...

227

conserved gene; putative drug target function;

Phase 4: April 2009

1JR9

44.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP91551
(show subtarget assignments)

8

cloned

No

CPF_1456

110799663

hypothetical protein CPF_1456 [Clostridi...

851

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Clostridium perfringens

IDP04329
(show subtarget assignments)

1

expressed

No

CPF_1466

110801108

putative lipoprotein [Clostridium perfri...

483

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04248
(show subtarget assignments)

1

in_pdb
4EDP

No

CPF_1477

110800354

ABC transporter, substrate-binding prote...

348

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EDP

100%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04392
(show subtarget assignments)

1

cloned

No

CPF_1500

110798925

putative lipoprotein [Clostridium perfri...

202

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04365
(show subtarget assignments)

1

cloned

No

CPF_1523

110798905

sensory box histidine kinase [Clostridiu...

787

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

11.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04366
(show subtarget assignments)

1

purified

No

CPF_1531

110800274

amino acid ABC transporter, amino acid-b...

262

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HV1

36.6%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04249
(show subtarget assignments)

1

expressed

No

CPF_1548

110800969

putative galactoside ABC transporter, ga...

354

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GLG

50.6%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04564
(show subtarget assignments)

1

cloned

No

CPF_1610

110800230

putative lipoprotein [Clostridium perfri...

125

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04393
(show subtarget assignments)

1

cloned

No

CPF_1645

110798596

lonB

ATP-dependent protease LonB [Clostridium...

570

conserved gene; putative drug target function;

Phase 4: April 2009

3K1J

29.4%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04251
(show subtarget assignments)

1

cloned

No

CPF_1751

110801372

virS

sensor histidine kinase VirS [Clostridiu...

440

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP91082
(show subtarget assignments)

8

cloned

No

CPF_1776

110800219

ABC transporter, permease/ATP-binding pr...

589

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

39.2%

Clostridium perfringens

IDP04252
(show subtarget assignments)

1

cloned

No

CPF_1780

110799805

putative lipoprotein [Clostridium perfri...

445

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04253
(show subtarget assignments)

1

purified

No

CPF_1800

110800480

prs

phosphoribosylpyrophosphate synthetase [...

364

conserved gene; putative drug target function;

Phase 4: April 2009

2C4K

25.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04565
(show subtarget assignments)

1

cloned

No

CPF_1805

110798813

putative lipoprotein [Clostridium perfri...

281

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04307
(show subtarget assignments)

1

cloned

No

CPF_1812

110799901

putative lipoprotein [Clostridium perfri...

44

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

IDP04254
(show subtarget assignments)

1

cloned

No

CPF_1823

110798846

putative lipoprotein [Clostridium perfri...

233

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP91550
(show subtarget assignments)

8

purified

No

CPF_1845

110799546

FmtC domain-containing protein [Clostrid...

395

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Clostridium perfringens

IDP91549
(show subtarget assignments)

8

cloned

No

CPF_1846

110800166

hypothetical protein CPF_1846 [Clostridi...

159

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Clostridium perfringens

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04566
(show subtarget assignments)

1

expressed

No

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04092
(show subtarget assignments)

1

cloned

No

CPF_1925

110801017

spoVS

stage V sporulation protein S [Clostridi...

86

conserved gene; putative drug target function;

Phase 4: April 2009

2EH1

57%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04036
(show subtarget assignments)

1

cloned

No

CPF_1970

110800938

smc

chromosome segregation protein SMC [Clos...

1185

conserved gene; putative drug target function;

Phase 4: April 2009

3AUX

8.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04256
(show subtarget assignments)

1

purified

No

CPF_2006

110801043

spoIVA

stage IV sporulation protein A [Clostrid...

491

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP04258
(show subtarget assignments)

1

soluble

No

CPF_2010

110801347

sensory box histidine kinase [Clostridiu...

571

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

17.3%

Clostridium perfringens

Regulatory functions

IDP04259
(show subtarget assignments)

1

cloned

No

CPF_2018

110799691

ftsZ

cell division protein FtsZ [Clostridium ...

381

conserved gene; putative drug target function;

Phase 4: April 2009

2VAM

58%

Clostridium perfringens

Cellular processes

Cell division

IDP04260
(show subtarget assignments)

1

cloned

No

CPF_2020

110798885

pilT

twitching motility protein PilT [Clostri...

350

conserved gene; putative drug target function;

Phase 4: April 2009

2EWV

49.1%

Clostridium perfringens

Cellular processes

Chemotaxis and motility

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04262
(show subtarget assignments)

1

cloned

No

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04263
(show subtarget assignments)

1

cloned

No

CPF_2068

110800995

stage IV sporulation protein B [Clostrid...

386

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04727
(show subtarget assignments)

1

purified

No

CPF_2072

110800396

hemolysin A [Clostridium perfringens ATC...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3HP7

49.8%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04019
(show subtarget assignments)

1

cloned

No

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

3TUF

24.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

Targets