Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05518 (show subtarget assignments)	1	cloned	No	CD1702	126699308	thiC	thiamine biosynthesis protein ThiC [Clos...	438	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3EPM	43.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP02122 (show subtarget assignments)	1	cloned	No	CBU_0090	29540712	tolB	tolB protein [Coxiella burnetii RSA 493]...	437	Conserved; Drug target functions	Phase 3: June 2008	1C5K	40.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP02597 (show subtarget assignments)	1	expressed	No	YPO3472	16123618		putative sugar binding protein [Yersinia...	437	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1EU8	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00498 (show subtarget assignments)	1	cloned	No	YPO0166	16120509		putative glycosyl hydrolase	437	Drug Target Function	Phase 2: March 2008	1S6Y	52.6%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP90104 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_004	68449081		ankyrin-like protein [Monkeypox virus]	437	similar to CPXV-GRI-C1L, MPXV-ZAI96-D1L/N4R	Community Requests	2Y1L	9.6%	Monkeypox virus

IDP00418 (show subtarget assignments)	1	crystallized	No	YPO0910	16121215	pepP	proline aminopeptidase P II	437	Drug Target Function	Phase 2: March 2008	1A16	81.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90165 (show subtarget assignments)	8	purified	No	CD1834	123174271		3-phosphoshikimate 1-carboxyvinyltransfe...	437	Potential drug target. Shikimate pathway enzyme	Community Requests	3NVS	32.5%	Clostridium difficile

IDP05385 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1686	30255979		putative flagellar hook protein FlgE [Ba...	437	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A69	30.9%	Bacillus anthracis	Cellular processes: Chemotaxis and motility

IDP01124 (show subtarget assignments)	1	purified	No	BA_4938	33301353		UDP-N-acetylmuramate--L-alanine ligase (...	436	Conserved Gene / Pathway	Phase 2: March 2008	1J6U	30.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04187 (show subtarget assignments)	1	expressed	No	VCA0723	15601479		3-hydroxy-3-methylglutaryl CoA reductase...	436	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1DQ8	35.5%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05493 (show subtarget assignments)	1	cloned	No	CD0231	126697802	flgK	putative flagellar hook-associated prote...	436	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP00544 (show subtarget assignments)	1	purified	No	YPO2746	16122950	fadI	3-ketoacyl-CoA thiolase	436	Virulence Associated Factor	Phase 2: March 2008	1ULQ	37.4%	Yersinia pestis	Cellular processes	Detoxification

IDP91514 (show subtarget assignments)	8	expressed	No	VV2_1517	27367864		agglutination protein [Vibrio vulnificus...	436	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YC9	16.5%	Vibrio vulnificus

IDP00488 (show subtarget assignments)	1	expressed	No	YPO1496	16121769		putative heme-binding protein	436	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Central intermediary metabolism	Sulfur metabolism

IDP01851 (show subtarget assignments)	1	cloned	No	GBAA5427	47778402		endopeptidase lytE, putative [Bacillus a...	436	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3H41	9.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01000 (show subtarget assignments)	1	expressed	No	STM2389	16765716	fadI	3-ketoacyl-CoA thiolase	436	Conserved Gene / Pathway	Phase 2: March 2008	1ULQ	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP02031 (show subtarget assignments)	1	cloned	No	lmo2504	16804542		hypothetical protein lmo2504 [Listeria m...	436	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2GU1	17.2%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00824 (show subtarget assignments)	1	cloned	No	SACOL2418	57285148		IgG-binding protein SBI	436	Conserved Gene / Pathway	Phase 2: March 2008	2WY7	16.1%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP02392 (show subtarget assignments)	1	soluble	No	GBAA2294	47527593		hypothetical protein GBAA2294 [Bacillus ...	436	Conserved; Essential;	Phase 3: June 2008	3I4J	38.3%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01985 (show subtarget assignments)	1	expressed	No	CBU_1882	29542439	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	435	Conserved; Drug target functions	Phase 3: June 2008	4E77	60.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02835 (show subtarget assignments)	1	expressed	No	FTT0631	56707756	hflX	protease, GTP-binding subunit [Francisel...	435	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2QTF	22.8%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02638 (show subtarget assignments)	1	in_pdb 3LG3	No	YPO3725	16123862	aceA	isocitrate lyase [Yersinia pestis CO92]	435	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3LG3	100%	Yersinia pestis	Energy metabolism	TCA cycle

IDP01881 (show subtarget assignments)	1	cloned	No	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90173 (show subtarget assignments)	8	cloned	No	AAM13464.1	20153003	CPXV017 CDS	CPXV017 protein	435	ankyrin repeat protein	Community Requests	2BKG	9.9%	Cowpox virus	conserved hypothetical proteins	0

IDP90871 (show subtarget assignments)	8	in_crystallization_trials	No	VC1110	15641123		seryl-tRNA synthetase [Vibrio cholerae O...	435	Predicted Essential	Community Requests	2DQ3	50.3%	Vibrio cholerae

IDP02582 (show subtarget assignments)	1	soluble	No	Cj1349c	15792672		fibronectin/fibrinogen-binding protein [...	435	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	3DOA	10.6%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01436 (show subtarget assignments)	1	crystallized	No	VC1976	15641978		menaquinone-specific isochorismate synth...	435	Drug Target Function	Phase 2: March 2008	3GSE	42.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04442 (show subtarget assignments)	8	soluble	No	YPO0494	115346303	b0053	survival protein SurA precursor (peptidy...	434	virulence/pathogenesis / drug target; conserved gene; putative drug target function;	Community Requests	1M5Y	71%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP04600 (show subtarget assignments)	1	cloned	No	BAS2547	49185555		preprotein translocase subunit SecY [Bac...	434	Proposed to be essential proteins	Phase 4: April 2009	3DIN	42.2%	Bacillus anthracis

IDP04146 (show subtarget assignments)	1	expressed	No	YPO2147	218929248	dadA	D-amino acid dehydrogenase small subunit...	434	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PJ5	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP90784 (show subtarget assignments)	8	in_pdb 3PYZ 3NRS 3N2A 3QCZ	No	YPO2769	16122973	folC	bifunctional folylpolyglutamate synthase...	434	Predicted Essential	Community Requests	3N2A	100%	Yersinia pestis

IDP04157 (show subtarget assignments)	1	soluble	No	VC1085	15641098		sensor histidine kinase [Vibrio cholerae...	434	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.1%	Vibrio cholerae	Regulatory functions	Other

IDP91336 (show subtarget assignments)	8	expressed	No	VV2_0152	27366608		arylsulfatase regulator [Vibrio vulnific...	434	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP00021 (show subtarget assignments)	1	in_pdb 3SG1	No	BA_5529	81714862		UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Homolog	Phase 1: October 2007	3SG1	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01422 (show subtarget assignments)	1	expressed	No	VC1549	15641557		glycerol-3-phosphate ABC transporter, pe...	434	Conserved Gene / Pathway	Phase 2: March 2008	2HEU	20%	Vibrio cholerae	Transport and binding proteins	Other

IDP05770 (show subtarget assignments)	1	cloned	No	VC_0465	9654891		tyrosyl-tRNA synthetase [Vibrio cholerae...	434	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2TS1	50%	Vibrio cholerae	Protein synthesis: tRNA aminoacylation

IDP02280 (show subtarget assignments)	1	in_pdb 3L44	Yes	GBAA0531	47525801	hemL-1	glutamate-1-semialdehyde aminotransferas...	434	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L44	99.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00314 (show subtarget assignments)	1	expressed	No	CBU_0751	29654085	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Function	Phase 2: March 2008	1EJC	57.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91490 (show subtarget assignments)	8	expressed	No	VP1695	28898469		putative type III export protein PscD [V...	433	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	4A0E	5.8%	Vibrio parahaemolyticus

IDP02403 (show subtarget assignments)	1	expressed	No	Cj1024c	15792351		sigma-54 dependent DNA-binding response ...	433	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3DZD	36%	Campylobacter jejuni	Transport and binding proteins	Amino acids, peptides and amines

IDP04588 (show subtarget assignments)	1	cloned	No	BAS0130	49183164		preprotein translocase subunit SecY [Bac...	433	Proposed to be essential proteins	Phase 4: April 2009	3DIN	43.8%	Bacillus anthracis

IDP02801 (show subtarget assignments)	1	soluble	No	lmo1993	16804032	pdp	pyrimidine-nucleoside phosphorylase [Lis...	433	Predicted involvement in glycosyl group metabolism; DNA binding Motifs	Phase 3: June 2008	3H5Q	76.4%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP05361 (show subtarget assignments)	1	cloned	No	BA_1162	30254880		alpha-amylase family protein [Bacillus a...	433	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1CYG	26.7%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00692 (show subtarget assignments)	1	in_pdb 3H5Q	Yes	SACOL2128	57286344	pdp	pyrimidine-nucleoside phosphorylase	433	Drug Target Function	Phase 2: March 2008	3H5Q	99.8%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02768 (show subtarget assignments)	1	purified	No	GBAA4689	47529988	folC	folylpolyglutamate synthase [Bacillus an...	433	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1O5Z	34.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP05741 (show subtarget assignments)	1	purified	No	CD2371	126699986	nadB	L-aspartate oxidase [Clostridium diffici...	433	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1CHU	37%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP00634 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1722	57284733	tig	trigger factor	433	Drug Target Function	Phase 2: March 2008	1W26	31.6%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP04633 (show subtarget assignments)	1	in_pdb 4EEI	No	FTT0015	56707195	purB	adenylosuccinate lyase [Francisella tula...	432	conserved gene; putative drug target function;	Phase 4: April 2009	4EEI	100%	Francisella tularensis

IDP92039 (show subtarget assignments)	8	selected	No	TGME49_036050	237839385		fructose-bisphosphate aldolase, putative...	432	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3KX6	58.6%	Toxoplasma gondii

IDP90674 (show subtarget assignments)	8	cloned	No	Cj0542	15791903	hemA	glutamyl-tRNA reductase [Campylobacter j...	432	Predicted Essential	Community Requests	1GPJ	27.3%	Campylobacter jejuni

IDP02327 (show subtarget assignments)	1	expressed	No	YPO1320	16121602	dacC	D-alanyl-D-alanine carboxypeptidase [Yer...	432	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	3IT9	60.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05333 (show subtarget assignments)	1	cloned	No	BAS2031	49185042	-	aspartyl-tRNA synthetase [Bacillus anthr...	432	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1N9W	49.5%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP90337 (show subtarget assignments)	8	expressed	No	CT_623	6578109		CHLPN 76kDa Homolog [Chlamydia trachomat...	432	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04404 (show subtarget assignments)	1	cloned	No	VC2602	15642597		adenylosuccinate synthetase [Vibrio chol...	432	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KJX	75.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00422 (show subtarget assignments)	1	in_pdb 3HID	No	YPO0378	16120713	purA	adenylosuccinate synthetase	432	Virulence Associated Factor	Phase 2: March 2008	3HID	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04717 (show subtarget assignments)	1	cloned	No	YPO0832	218928008	agaZ	putative tagatose 6-phosphate kinase [Ye...	432	conserved gene; putative drug target function;	Phase 4: April 2009	2FIQ	51.6%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP01412 (show subtarget assignments)	1	purified	No	VC1122	15641135		cyclopropane-fatty-acyl-phospholipid syn...	432	Drug Target Function	Phase 2: March 2008	1KPI	18.7%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02431 (show subtarget assignments)	1	crystallized	No	CBU_1770	29542327		ABC transporter, ATP-binding protein [Co...	432	Conserved; Drug target functions	Phase 3: June 2008	2YYZ	23.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04127 (show subtarget assignments)	1	crystallized	No	YPO2889	115348559	pepB	peptidase B [Yersinia pestis CO92]	432	drug target; putative drug target function;	Phase 4: April 2009	1BLL	32.9%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90615 (show subtarget assignments)	8	in_crystallization_trials	No	VC0626	15640646		glutamate-1-semialdehyde aminotransferas...	432	Predicted Essential	Community Requests	4E77	72%	Vibrio cholerae

IDP01018 (show subtarget assignments)	1	expressed	No	STM2894	16766200	invC	ATP synthase SpaL	431	Conserved Gene / Pathway	Phase 2: March 2008	2OBL	38.7%	Salmonella enterica	Transport and binding proteins	Other

IDP00996 (show subtarget assignments)	1	in_crystallization_trials	No	STM2310	16765637	menF	menaquinone-specific isochorismate synth...	431	Drug Target Function	Phase 2: March 2008	2EUA	78.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP05768 (show subtarget assignments)	1	cloned	No	SACOL0553	57651385		hypothetical protein SACOL0553 [Staphylo...	431	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3A2K	28.1%	Staphylococcus aureus	Protein synthesis: tRNA and rRNA base modification

IDP00110 (show subtarget assignments)	1	purified	No	NT01SF4145	30043548	glgC	glucose-1-phosphate adenylyltransferase ...	431	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3BRK	55.2%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04201 (show subtarget assignments)	1	expressed	No	CPF_0499	110800753		sensor histidine kinase [Clostridium per...	431	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP02588 (show subtarget assignments)	6	cloned	No	AAC67800	3328615	gseA	KDO Transferase [Chlamydia trachomatis D...	431	KdtA is responsible for the formation of the genus-specific lipopolysaccharide e...	Phase 3: June 2008	2XCI	26.5%	Chlamydia trachomatis	N/A	N/A

IDP01882 (show subtarget assignments)	1	soluble	No	FTT0927	56708027	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	431	Drug Target	Phase 3: June 2008	4E77	58.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04412 (show subtarget assignments)	1	cloned	No	CPF_0435	110799959		putative lipoprotein [Clostridium perfri...	431	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP05545 (show subtarget assignments)	1	cloned	No	Cj0845c	6968286	gltX	putative fructose-1,6-bisphosphatase [Ca...	431	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2O5R	33.8%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP02253 (show subtarget assignments)	1	soluble	No	GBAA1968	47527263	hom-1	homoserine dehydrogenase [Bacillus anthr...	431	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3MTJ	37.1%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP91651 (show subtarget assignments)	8	cloned	No	NP_216894	15609515		lysine-N-oxygenase MBTG (L-lysine 6-mono...	431	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests			Mycobacterium tuberculosis

IDP90835 (show subtarget assignments)	8	soluble	No	S0893	30062380	serS	seryl-tRNA synthetase [Shigella flexneri...	430	Predicted Essential	Community Requests	2DQ3	55.5%	Shigella flexneri

IDP91553 (show subtarget assignments)	8	expressed	No	BAB38471	13364525	ECs5048	hypothetical protein [Escherichia coli O...	430	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2J8K	10.5%	Escherichia coli

IDP05209 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1494	57650409	asnC	asparaginyl-tRNA synthetase [Staphylococ...	430	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	45.8%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP00493 (show subtarget assignments)	1	expressed	No	YPO1124	16121424	tolB	translocation protein TolB	430	Conserved Gene / Pathway	Phase 2: March 2008	1C5K	84.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP05708 (show subtarget assignments)	1	soluble	No	lmo2839	16804876	-	hypothetical protein lmo2839 [Listeria m...	430	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QUF	24.4%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP90923 (show subtarget assignments)	8	purified	No	STM0963	16764324	serS	seryl-tRNA synthetase [Salmonella typhim...	430	Predicted Essential	Community Requests	2DQ3	55.5%	Salmonella enterica

IDP00915 (show subtarget assignments)	1	in_crystallization_trials	No	STM0236	16763626	tilS	tRNA(Ile)-lysidine synthetase	430	Drug Target Function	Phase 2: March 2008	1NI5	75.3%	Salmonella enterica	Cellular processes	Cell division

IDP90714 (show subtarget assignments)	8	in_crystallization_trials	No	YPO1379	16121659	serS	seryl-tRNA synthetase [Yersinia pestis C...	430	Predicted Essential	Community Requests	2DQ3	55.3%	Yersinia pestis

IDP91065 (show subtarget assignments)	8	expressed	No	VC0395_A0354	147674291	tcpB	toxin co-regulated pilus biosynthesis pr...	430	vaccine candidate / For Vibrio cholerae to colonize the human intestine and cause cholera, it must e...	Community Requests			Vibrio cholerae

IDP00227 (show subtarget assignments)	1	expressed	No	YPO3249	16123408	-	putative amino acid hydrolase	430	Virulence	Phase 1: October 2007	3N5F	36%	Yersinia pestis	Hypothetical proteins	Conserved

IDP05239 (show subtarget assignments)	1	cloned	No	lmo1896	16803935	ansB	asparaginyl-tRNA synthetase [Listeria mo...	430	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	45.3%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05525 (show subtarget assignments)	1	soluble	No	CD2550	126700167		putative sugar transporter, substrate-bi...	430	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	25.8%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP91280 (show subtarget assignments)	8	soluble	No	NT05BA5064	49181767		conserved hypothetical protein [Bacillus...	430	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	4DN7	19.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP00355 (show subtarget assignments)	1	in_pdb 3R38	Yes	lmo2526	16804564	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	430	Drug Target Function	Phase 2: March 2008	3R38	100%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00157 (show subtarget assignments)	1	soluble	No	VC0829	15640846	tcpB	toxin co-regulated pilus biosynthesis pr...	430	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00679 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1699	57284711	obgE	GTPase ObgE	430	Drug Target Function	Phase 2: March 2008	1LNZ	54.2%	Staphylococcus aureus	Unknown function	General

IDP91458 (show subtarget assignments)	8	in_pdb 4E6Y	No	VV1_0162	27363645	gltA	type II citrate synthase [Vibrio vulnifi...	429	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	4E6Y	100%	Vibrio vulnificus

IDP91918 (show subtarget assignments)	8	selected	No	SpneCM_010100009348	298255780		surface protein PspA, partial [Streptoco...	429	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2V04	29.8%	Streptococcus pneumoniae

IDP02201 (show subtarget assignments)	1	soluble	No	YPO0461	16120790	thrC	threonine synthase [Yersinia pestis CO92...	429	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1VB3	82.3%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01913 (show subtarget assignments)	1	cloned	No	GBAA1426	47526698	hisD	histidinol dehydrogenase [Bacillus anthr...	429	Conserved; Drug target functions	Phase 3: June 2008	1K75	39.2%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP00936 (show subtarget assignments)	1	soluble	No	STM0793	16764156	bioA	adenosylmethionine--8-amino-7-oxononanoa...	429	Conserved Gene / Pathway	Phase 2: March 2008	1MLY	86.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00012 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2953	61211623		3-phosphoshikimate 1-carboxyvinyltransfe...	429	Drug Target Homolog	Phase 1: October 2007	3RMT	66.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01765 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5716	47531053	purA	adenylosuccinate synthetase [Bacillus an...	429	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GIM	47.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00022 (show subtarget assignments)	1	cloned	No	BA_5578	81714842		UDP-N-acetylglucosamine 1-carboxyvinyltr...	429	Drug Target Homolog	Phase 1: October 2007	3SG1	49.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01397 (show subtarget assignments)	1	purified	No	VC0755	161582019		aminopeptidase B	429	Drug Target Function	Phase 2: March 2008	3H8E	32.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90620 (show subtarget assignments)	8	expressed	No	VC0275	15640304		phosphoribosylamine--glycine ligase [Vib...	429	Predicted Essential	Community Requests	1GSO	77.9%	Vibrio cholerae

IDP02781 (show subtarget assignments)	1	in_pdb 3K28	No	GBAA4693	47529992	hemL-2	glutamate-1-semialdehyde aminotransferas...	429	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K28	100%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90723 (show subtarget assignments)	8	purified	No	Cj0821	15792159	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	429	Predicted Essential	Community Requests	1HM0	40.1%	Campylobacter jejuni

IDP04204 (show subtarget assignments)	1	soluble	No	CPF_2382	110799414	obgE	GTPase ObgE [Clostridium perfringens ATC...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1LNZ	44.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05518
(show subtarget assignments)

1

cloned

No

CD1702

126699308

thiC

thiamine biosynthesis protein ThiC [Clos...

438

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3EPM

43.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP02122
(show subtarget assignments)

1

cloned

No

CBU_0090

29540712

tolB

tolB protein [Coxiella burnetii RSA 493]...

437

Conserved; Drug target functions

Phase 3: June 2008

1C5K

40.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP02597
(show subtarget assignments)

1

expressed

No

YPO3472

16123618

putative sugar binding protein [Yersinia...

437

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1EU8

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00498
(show subtarget assignments)

1

cloned

No

YPO0166

16120509

putative glycosyl hydrolase

437

Drug Target Function

Phase 2: March 2008

1S6Y

52.6%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP90104
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_004

68449081

ankyrin-like protein [Monkeypox virus]

437

similar to CPXV-GRI-C1L, MPXV-ZAI96-D1L/N4R

Community Requests

2Y1L

9.6%

Monkeypox virus

IDP00418
(show subtarget assignments)

1

crystallized

No

YPO0910

16121215

pepP

proline aminopeptidase P II

437

Drug Target Function

Phase 2: March 2008

1A16

81.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90165
(show subtarget assignments)

8

purified

No

CD1834

123174271

3-phosphoshikimate 1-carboxyvinyltransfe...

437

Potential drug target. Shikimate pathway enzyme

Community Requests

3NVS

32.5%

Clostridium difficile

IDP05385
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1686

30255979

putative flagellar hook protein FlgE [Ba...

437

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A69

30.9%

Bacillus anthracis

Cellular processes: Chemotaxis and motility

IDP01124
(show subtarget assignments)

1

purified

No

BA_4938

33301353

UDP-N-acetylmuramate--L-alanine ligase (...

436

Conserved Gene / Pathway

Phase 2: March 2008

1J6U

30.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04187
(show subtarget assignments)

1

expressed

No

VCA0723

15601479

3-hydroxy-3-methylglutaryl CoA reductase...

436

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1DQ8

35.5%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05493
(show subtarget assignments)

1

cloned

No

CD0231

126697802

flgK

putative flagellar hook-associated prote...

436

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP00544
(show subtarget assignments)

1

purified

No

YPO2746

16122950

fadI

3-ketoacyl-CoA thiolase

436

Virulence Associated Factor

Phase 2: March 2008

1ULQ

37.4%

Yersinia pestis

Cellular processes

Detoxification

IDP91514
(show subtarget assignments)

8

expressed

No

VV2_1517

27367864

agglutination protein [Vibrio vulnificus...

436

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YC9

16.5%

Vibrio vulnificus

IDP00488
(show subtarget assignments)

1

expressed

No

YPO1496

16121769

putative heme-binding protein

436

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Central intermediary metabolism

Sulfur metabolism

IDP01851
(show subtarget assignments)

1

cloned

No

GBAA5427

47778402

endopeptidase lytE, putative [Bacillus a...

436

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3H41

9.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01000
(show subtarget assignments)

1

expressed

No

STM2389

16765716

fadI

3-ketoacyl-CoA thiolase

436

Conserved Gene / Pathway

Phase 2: March 2008

1ULQ

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP02031
(show subtarget assignments)

1

cloned

No

lmo2504

16804542

hypothetical protein lmo2504 [Listeria m...

436

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2GU1

17.2%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00824
(show subtarget assignments)

1

cloned

No

SACOL2418

57285148

IgG-binding protein SBI

436

Conserved Gene / Pathway

Phase 2: March 2008

2WY7

16.1%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP02392
(show subtarget assignments)

1

soluble

No

GBAA2294

47527593

hypothetical protein GBAA2294 [Bacillus ...

436

Conserved; Essential;

Phase 3: June 2008

3I4J

38.3%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01985
(show subtarget assignments)

1

expressed

No

CBU_1882

29542439

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

435

Conserved; Drug target functions

Phase 3: June 2008

4E77

60.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02835
(show subtarget assignments)

1

expressed

No

FTT0631

56707756

hflX

protease, GTP-binding subunit [Francisel...

435

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2QTF

22.8%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02638
(show subtarget assignments)

1

in_pdb
3LG3

No

YPO3725

16123862

aceA

isocitrate lyase [Yersinia pestis CO92]

435

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3LG3

100%

Yersinia pestis

Energy metabolism

TCA cycle

IDP01881
(show subtarget assignments)

1

cloned

No

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90173
(show subtarget assignments)

8

cloned

No

AAM13464.1

20153003

CPXV017 CDS

CPXV017 protein

435

ankyrin repeat protein

Community Requests

2BKG

9.9%

Cowpox virus

conserved hypothetical proteins

0

IDP90871
(show subtarget assignments)

8

in_crystallization_trials

No

VC1110

15641123

seryl-tRNA synthetase [Vibrio cholerae O...

435

Predicted Essential

Community Requests

2DQ3

50.3%

Vibrio cholerae

IDP02582
(show subtarget assignments)

1

soluble

No

Cj1349c

15792672

fibronectin/fibrinogen-binding protein [...

435

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

3DOA

10.6%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01436
(show subtarget assignments)

1

crystallized

No

VC1976

15641978

menaquinone-specific isochorismate synth...

435

Drug Target Function

Phase 2: March 2008

3GSE

42.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04442
(show subtarget assignments)

8

soluble

No

YPO0494

115346303

b0053

survival protein SurA precursor (peptidy...

434

virulence/pathogenesis / drug target; conserved gene; putative drug target function;

Community Requests

1M5Y

71%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP04600
(show subtarget assignments)

1

cloned

No

BAS2547

49185555

preprotein translocase subunit SecY [Bac...

434

Proposed to be essential proteins

Phase 4: April 2009

3DIN

42.2%

Bacillus anthracis

IDP04146
(show subtarget assignments)

1

expressed

No

YPO2147

218929248

dadA

D-amino acid dehydrogenase small subunit...

434

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PJ5

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP90784
(show subtarget assignments)

8

in_pdb
3PYZ
3NRS
3N2A
3QCZ

No

YPO2769

16122973

folC

bifunctional folylpolyglutamate synthase...

434

Predicted Essential

Community Requests

3N2A

100%

Yersinia pestis

IDP04157
(show subtarget assignments)

1

soluble

No

VC1085

15641098

sensor histidine kinase [Vibrio cholerae...

434

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.1%

Vibrio cholerae

Regulatory functions

Other

IDP91336
(show subtarget assignments)

8

expressed

No

VV2_0152

27366608

arylsulfatase regulator [Vibrio vulnific...

434

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP00021
(show subtarget assignments)

1

in_pdb
3SG1

No

BA_5529

81714862

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Homolog

Phase 1: October 2007

3SG1

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01422
(show subtarget assignments)

1

expressed

No

VC1549

15641557

glycerol-3-phosphate ABC transporter, pe...

434

Conserved Gene / Pathway

Phase 2: March 2008

2HEU

20%

Vibrio cholerae

Transport and binding proteins

Other

IDP05770
(show subtarget assignments)

1

cloned

No

VC_0465

9654891

tyrosyl-tRNA synthetase [Vibrio cholerae...

434

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2TS1

50%

Vibrio cholerae

Protein synthesis: tRNA aminoacylation

IDP02280
(show subtarget assignments)

1

in_pdb
3L44

Yes

GBAA0531

47525801

hemL-1

glutamate-1-semialdehyde aminotransferas...

434

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L44

99.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00314
(show subtarget assignments)

1

expressed

No

CBU_0751

29654085

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Function

Phase 2: March 2008

1EJC

57.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91490
(show subtarget assignments)

8

expressed

No

VP1695

28898469

putative type III export protein PscD [V...

433

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

4A0E

5.8%

Vibrio parahaemolyticus

IDP02403
(show subtarget assignments)

1

expressed

No

Cj1024c

15792351

sigma-54 dependent DNA-binding response ...

433

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3DZD

36%

Campylobacter jejuni

Transport and binding proteins

Amino acids, peptides and amines

IDP04588
(show subtarget assignments)

1

cloned

No

BAS0130

49183164

preprotein translocase subunit SecY [Bac...

433

Proposed to be essential proteins

Phase 4: April 2009

3DIN

43.8%

Bacillus anthracis

IDP02801
(show subtarget assignments)

1

soluble

No

lmo1993

16804032

pdp

pyrimidine-nucleoside phosphorylase [Lis...

433

Predicted involvement in glycosyl group metabolism; DNA binding Motifs

Phase 3: June 2008

3H5Q

76.4%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP05361
(show subtarget assignments)

1

cloned

No

BA_1162

30254880

alpha-amylase family protein [Bacillus a...

433

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1CYG

26.7%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00692
(show subtarget assignments)

1

in_pdb
3H5Q

Yes

SACOL2128

57286344

pdp

pyrimidine-nucleoside phosphorylase

433

Drug Target Function

Phase 2: March 2008

3H5Q

99.8%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02768
(show subtarget assignments)

1

purified

No

GBAA4689

47529988

folC

folylpolyglutamate synthase [Bacillus an...

433

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1O5Z

34.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP05741
(show subtarget assignments)

1

purified

No

CD2371

126699986

nadB

L-aspartate oxidase [Clostridium diffici...

433

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1CHU

37%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP00634
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1722

57284733

tig

trigger factor

433

Drug Target Function

Phase 2: March 2008

1W26

31.6%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP04633
(show subtarget assignments)

1

in_pdb
4EEI

No

FTT0015

56707195

purB

adenylosuccinate lyase [Francisella tula...

432

conserved gene; putative drug target function;

Phase 4: April 2009

4EEI

100%

Francisella tularensis

IDP92039
(show subtarget assignments)

8

selected

No

TGME49_036050

237839385

fructose-bisphosphate aldolase, putative...

432

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3KX6

58.6%

Toxoplasma gondii

IDP90674
(show subtarget assignments)

8

cloned

No

Cj0542

15791903

hemA

glutamyl-tRNA reductase [Campylobacter j...

432

Predicted Essential

Community Requests

1GPJ

27.3%

Campylobacter jejuni

IDP02327
(show subtarget assignments)

1

expressed

No

YPO1320

16121602

dacC

D-alanyl-D-alanine carboxypeptidase [Yer...

432

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

3IT9

60.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05333
(show subtarget assignments)

1

cloned

No

BAS2031

49185042

-

aspartyl-tRNA synthetase [Bacillus anthr...

432

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1N9W

49.5%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP90337
(show subtarget assignments)

8

expressed

No

CT_623

6578109

CHLPN 76kDa Homolog [Chlamydia trachomat...

432

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04404
(show subtarget assignments)

1

cloned

No

VC2602

15642597

adenylosuccinate synthetase [Vibrio chol...

432

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KJX

75.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00422
(show subtarget assignments)

1

in_pdb
3HID

No

YPO0378

16120713

purA

adenylosuccinate synthetase

432

Virulence Associated Factor

Phase 2: March 2008

3HID

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04717
(show subtarget assignments)

1

cloned

No

YPO0832

218928008

agaZ

putative tagatose 6-phosphate kinase [Ye...

432

conserved gene; putative drug target function;

Phase 4: April 2009

2FIQ

51.6%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP01412
(show subtarget assignments)

1

purified

No

VC1122

15641135

cyclopropane-fatty-acyl-phospholipid syn...

432

Drug Target Function

Phase 2: March 2008

1KPI

18.7%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02431
(show subtarget assignments)

1

crystallized

No

CBU_1770

29542327

ABC transporter, ATP-binding protein [Co...

432

Conserved; Drug target functions

Phase 3: June 2008

2YYZ

23.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04127
(show subtarget assignments)

1

crystallized

No

YPO2889

115348559

pepB

peptidase B [Yersinia pestis CO92]

432

drug target; putative drug target function;

Phase 4: April 2009

1BLL

32.9%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90615
(show subtarget assignments)

8

in_crystallization_trials

No

VC0626

15640646

glutamate-1-semialdehyde aminotransferas...

432

Predicted Essential

Community Requests

4E77

72%

Vibrio cholerae

IDP01018
(show subtarget assignments)

1

expressed

No

STM2894

16766200

invC

ATP synthase SpaL

431

Conserved Gene / Pathway

Phase 2: March 2008

2OBL

38.7%

Salmonella enterica

Transport and binding proteins

Other

IDP00996
(show subtarget assignments)

1

in_crystallization_trials

No

STM2310

16765637

menF

menaquinone-specific isochorismate synth...

431

Drug Target Function

Phase 2: March 2008

2EUA

78.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP05768
(show subtarget assignments)

1

cloned

No

SACOL0553

57651385

hypothetical protein SACOL0553 [Staphylo...

431

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3A2K

28.1%

Staphylococcus aureus

Protein synthesis: tRNA and rRNA base modification

IDP00110
(show subtarget assignments)

1

purified

No

NT01SF4145

30043548

glgC

glucose-1-phosphate adenylyltransferase ...

431

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3BRK

55.2%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04201
(show subtarget assignments)

1

expressed

No

CPF_0499

110800753

sensor histidine kinase [Clostridium per...

431

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP02588
(show subtarget assignments)

6

cloned

No

AAC67800

3328615

gseA

KDO Transferase [Chlamydia trachomatis D...

431

KdtA is responsible for the formation of the genus-specific lipopolysaccharide e...

Phase 3: June 2008

2XCI

26.5%

Chlamydia trachomatis

N/A

IDP01882
(show subtarget assignments)

1

soluble

No

FTT0927

56708027

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

431

Drug Target

Phase 3: June 2008

4E77

58.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04412
(show subtarget assignments)

1

cloned

No

CPF_0435

110799959

putative lipoprotein [Clostridium perfri...

431

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP05545
(show subtarget assignments)

1

cloned

No

Cj0845c

6968286

gltX

putative fructose-1,6-bisphosphatase [Ca...

431

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2O5R

33.8%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP02253
(show subtarget assignments)

1

soluble

No

GBAA1968

47527263

hom-1

homoserine dehydrogenase [Bacillus anthr...

431

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3MTJ

37.1%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP91651
(show subtarget assignments)

8

cloned

No

NP_216894

15609515

lysine-N-oxygenase MBTG (L-lysine 6-mono...

431

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

Mycobacterium tuberculosis

IDP90835
(show subtarget assignments)

8

soluble

No

S0893

30062380

serS

seryl-tRNA synthetase [Shigella flexneri...

430

Predicted Essential

Community Requests

2DQ3

55.5%

Shigella flexneri

IDP91553
(show subtarget assignments)

8

expressed

No

BAB38471

13364525

ECs5048

hypothetical protein [Escherichia coli O...

430

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2J8K

10.5%

Escherichia coli

IDP05209
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1494

57650409

asnC

asparaginyl-tRNA synthetase [Staphylococ...

430

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

45.8%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP00493
(show subtarget assignments)

1

expressed

No

YPO1124

16121424

tolB

translocation protein TolB

430

Conserved Gene / Pathway

Phase 2: March 2008

1C5K

84.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP05708
(show subtarget assignments)

1

soluble

No

lmo2839

16804876

-

hypothetical protein lmo2839 [Listeria m...

430

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QUF

24.4%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP90923
(show subtarget assignments)

8

purified

No

STM0963

16764324

serS

seryl-tRNA synthetase [Salmonella typhim...

430

Predicted Essential

Community Requests

2DQ3

55.5%

Salmonella enterica

IDP00915
(show subtarget assignments)

1

in_crystallization_trials

No

STM0236

16763626

tilS

tRNA(Ile)-lysidine synthetase

430

Drug Target Function

Phase 2: March 2008

1NI5

75.3%

Salmonella enterica

Cellular processes

Cell division

IDP90714
(show subtarget assignments)

8

in_crystallization_trials

No

YPO1379

16121659

serS

seryl-tRNA synthetase [Yersinia pestis C...

430

Predicted Essential

Community Requests

2DQ3

55.3%

Yersinia pestis

IDP91065
(show subtarget assignments)

8

expressed

No

VC0395_A0354

147674291

tcpB

toxin co-regulated pilus biosynthesis pr...

430

vaccine candidate / For Vibrio cholerae to colonize the human intestine and cause cholera, it must e...

Community Requests

Vibrio cholerae

IDP00227
(show subtarget assignments)

1

expressed

No

YPO3249

16123408

-

putative amino acid hydrolase

430

Virulence

Phase 1: October 2007

3N5F

36%

Yersinia pestis

Hypothetical proteins

Conserved

IDP05239
(show subtarget assignments)

1

cloned

No

lmo1896

16803935

ansB

asparaginyl-tRNA synthetase [Listeria mo...

430

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

45.3%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05525
(show subtarget assignments)

1

soluble

No

CD2550

126700167

putative sugar transporter, substrate-bi...

430

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

25.8%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP91280
(show subtarget assignments)

8

soluble

No

NT05BA5064

49181767

conserved hypothetical protein [Bacillus...

430

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

4DN7

19.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP00355
(show subtarget assignments)

1

in_pdb
3R38

Yes

lmo2526

16804564

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

430

Drug Target Function

Phase 2: March 2008

3R38

100%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00157
(show subtarget assignments)

1

soluble

No

VC0829

15640846

tcpB

toxin co-regulated pilus biosynthesis pr...

430

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00679
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1699

57284711

obgE

GTPase ObgE

430

Drug Target Function

Phase 2: March 2008

1LNZ

54.2%

Staphylococcus aureus

Unknown function

General

IDP91458
(show subtarget assignments)

8

in_pdb
4E6Y

No

VV1_0162

27363645

gltA

type II citrate synthase [Vibrio vulnifi...

429

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

4E6Y

100%

Vibrio vulnificus

IDP91918
(show subtarget assignments)

8

selected

No

SpneCM_010100009348

298255780

surface protein PspA, partial [Streptoco...

429

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2V04

29.8%

Streptococcus pneumoniae

IDP02201
(show subtarget assignments)

1

soluble

No

YPO0461

16120790

thrC

threonine synthase [Yersinia pestis CO92...

429

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1VB3

82.3%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01913
(show subtarget assignments)

1

cloned

No

GBAA1426

47526698

hisD

histidinol dehydrogenase [Bacillus anthr...

429

Conserved; Drug target functions

Phase 3: June 2008

1K75

39.2%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP00936
(show subtarget assignments)

1

soluble

No

STM0793

16764156

bioA

adenosylmethionine--8-amino-7-oxononanoa...

429

Conserved Gene / Pathway

Phase 2: March 2008

1MLY

86.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00012
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2953

61211623

3-phosphoshikimate 1-carboxyvinyltransfe...

429

Drug Target Homolog

Phase 1: October 2007

3RMT

66.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01765
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5716

47531053

purA

adenylosuccinate synthetase [Bacillus an...

429

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GIM

47.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00022
(show subtarget assignments)

1

cloned

No

BA_5578

81714842

UDP-N-acetylglucosamine 1-carboxyvinyltr...

429

Drug Target Homolog

Phase 1: October 2007

3SG1

49.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01397
(show subtarget assignments)

1

purified

No

VC0755

161582019

aminopeptidase B

429

Drug Target Function

Phase 2: March 2008

3H8E

32.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90620
(show subtarget assignments)

8

expressed

No

VC0275

15640304

phosphoribosylamine--glycine ligase [Vib...

429

Predicted Essential

Community Requests

1GSO

77.9%

Vibrio cholerae

IDP02781
(show subtarget assignments)

1

in_pdb
3K28

No

GBAA4693

47529992

hemL-2

glutamate-1-semialdehyde aminotransferas...

429

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K28

100%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90723
(show subtarget assignments)

8

purified

No

Cj0821

15792159

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

429

Predicted Essential

Community Requests

1HM0

40.1%

Campylobacter jejuni

IDP04204
(show subtarget assignments)

1

soluble

No

CPF_2382

110799414

obgE

GTPase ObgE [Clostridium perfringens ATC...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1LNZ

44.2%

Clostridium perfringens

Cellular processes

Sporulation and germination