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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 18 of 60, showing 100 records out of 5973 total, starting on record 1701
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91499
(
show subtarget assignments
)
8
cloned
No
VP1680
28898454
hypothetical protein VP1680 [Vibrio para...
492
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP91500
(
show subtarget assignments
)
8
cloned
No
VP1673
28898447
translocation protein in type III secret...
88
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP91501
(
show subtarget assignments
)
8
cloned
No
VP1674
28898448
translocation protein in type III secret...
261
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP91504
(
show subtarget assignments
)
8
cloned
No
VP1670
28898444
putative translocation protein in type I...
446
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP91508
(
show subtarget assignments
)
8
cloned
No
VP1666
28898440
hypothetical protein VP1666 [Vibrio para...
94
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XL3
44.7%
Vibrio parahaemolyticus
IDP91510
(
show subtarget assignments
)
8
cloned
No
VP1664
28898438
putative type III secretion protein [Vib...
126
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP91512
(
show subtarget assignments
)
8
cloned
No
VV2_0404
27366843
cytolysin [Vibrio vulnificus CMCP6]
468
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XEZ
25.9%
Vibrio vulnificus
IDP91515
(
show subtarget assignments
)
8
cloned
No
VV2_1587
27367932
malG
maltose transporter permease [Vibrio vul...
296
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2R6G
82.4%
Vibrio vulnificus
IDP91527
(
show subtarget assignments
)
8
cloned
No
AAX13509
89214483
etpA
EtpA [Escherichia coli ETEC H10407]
1767
virulence/pathogenesis /
The EtpA ETEC two-partner secretion (TPS) exoprotein [PMID: 16552055] is a highl...
Community Requests
3AK5
11.2%
Escherichia coli
IDP91549
(
show subtarget assignments
)
8
cloned
No
CPF_1846
110800166
hypothetical protein CPF_1846 [Clostridi...
159
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Clostridium perfringens
IDP91551
(
show subtarget assignments
)
8
cloned
No
CPF_1456
110799663
hypothetical protein CPF_1456 [Clostridi...
851
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Clostridium perfringens
IDP91566
(
show subtarget assignments
)
8
cloned
No
BAB34991
13361032
ECs1568
hypothetical protein [Escherichia coli O...
453
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91567
(
show subtarget assignments
)
8
cloned
No
BAB35235
13361277
ECs1812
hypothetical protein [Escherichia coli O...
441
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91578
(
show subtarget assignments
)
8
cloned
No
BAB37984
13364036
ECs4561
translocated intimin receptor Tir [Esche...
558
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2ZQK
12.2%
Escherichia coli
IDP91580
(
show subtarget assignments
)
8
cloned
No
CBU_0077
29540700
hypothetical protein
263
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91581
(
show subtarget assignments
)
8
cloned
No
CBU_0080
29540703
hypothetical protein
160
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91582
(
show subtarget assignments
)
8
cloned
No
CBU_0295
29540908
hypothetical protein
489
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91585
(
show subtarget assignments
)
8
cloned
No
CBU_0635
29541236
hypothetical protein
496
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91588
(
show subtarget assignments
)
8
cloned
No
BAA24463
2804527
YfiW [Bacillus subtilis]
258
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus subtilis
IDP91590
(
show subtarget assignments
)
8
cloned
No
PA0920
15596117
hypothetical protein PA0920 [Pseudomonas...
881
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Pseudomonas aeruginosa
IDP91594
(
show subtarget assignments
)
8
cloned
No
BAS1375
49184392
-
virulence factor MprF
861
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus anthracis
IDP91597
(
show subtarget assignments
)
8
cloned
No
BAA24464
2804528
YfiX [Bacillus subtilis]
610
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus subtilis
IDP91598
(
show subtarget assignments
)
8
cloned
No
BAB33448
13359481
ECs0025
hypothetical protein [Escherichia coli O...
473
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91600
(
show subtarget assignments
)
8
cloned
No
CBU_2059
29542610
hypothetical protein
400
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91601
(
show subtarget assignments
)
8
cloned
No
CBU_2052
29542603
hypothetical protein
300
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91603
(
show subtarget assignments
)
8
cloned
No
CBU_1963
29542518
hypothetical protein
633
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91604
(
show subtarget assignments
)
8
cloned
No
CBU_1823
29542379
hypothetical protein
349
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91605
(
show subtarget assignments
)
8
cloned
No
CBU_1825
29542381
hypothetical protein
115
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91607
(
show subtarget assignments
)
8
cloned
No
CBU_1776
29542333
hypothetical protein
181
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91608
(
show subtarget assignments
)
8
cloned
No
CBU_1525
29542084
hypothetical protein
382
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91609
(
show subtarget assignments
)
8
cloned
No
CBU_1524
29542083
hypothetical protein
219
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91626
(
show subtarget assignments
)
8
cloned
No
BAB34550
13360587
ECs1127
hypothetical protein [Escherichia coli O...
60
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91627
(
show subtarget assignments
)
8
cloned
No
BAB34984
13361025
ECs1561
hypothetical protein [Escherichia coli O...
1133
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91630
(
show subtarget assignments
)
8
cloned
No
BAB35233
13361275
ECs1810
hypothetical protein [Escherichia coli O...
88
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91636
(
show subtarget assignments
)
8
cloned
No
NP_217464
15610085
acyl-CoA synthetase [Mycobacterium tuber...
705
virulence/pathogenesis /
Required for the synthesis of the phthiocerol dimycocerosates and related compou...
Community Requests
2V7B
23%
Mycobacterium tuberculosis
IDP91637
(
show subtarget assignments
)
8
cloned
No
NP_215056
15607682
O-succinylbenzoic acid--CoA ligase [Myco...
362
drug target /
Potentially essential based on the transposon mutagenesis studies of Sassetti, C...
Community Requests
3NYQ
35%
Mycobacterium tuberculosis
IDP91639
(
show subtarget assignments
)
8
cloned
No
NP_216896
15609517
peptide synthetase MBTE (peptide synthas...
1682
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
2VSQ
17.7%
Mycobacterium tuberculosis
IDP91640
(
show subtarget assignments
)
8
cloned
No
NP_216900
15609521
bifunctional salicyl-AMP ligase/salicyl-...
565
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
1MD9
42.1%
Mycobacterium tuberculosis
IDP91641
(
show subtarget assignments
)
8
cloned
No
NP_216899
15609520
phenyloxazoline synthase MBTB (phenyloxa...
1414
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
2VSQ
23.6%
Mycobacterium tuberculosis
IDP91642
(
show subtarget assignments
)
8
cloned
No
NP_216895
15609516
peptide synthetase MBTF (peptide synthas...
1461
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
2VSQ
20.2%
Mycobacterium tuberculosis
IDP91643
(
show subtarget assignments
)
8
cloned
No
NP_215860
15608484
acyl carrier protein [Mycobacterium tube...
106
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
4DXE
19.8%
Mycobacterium tuberculosis
IDP91647
(
show subtarget assignments
)
8
cloned
No
NP_217446
57117038
acyl-CoA synthetase [Mycobacterium tuber...
583
virulence/pathogenesis /
Required for the synthesis of the phthiocerol dimycocerosates and related compou...
Community Requests
3E53
45.1%
Mycobacterium tuberculosis
IDP91648
(
show subtarget assignments
)
8
cloned
No
NP_217466
161352463
acyl-CoA synthetase [Mycobacterium tuber...
582
virulence/pathogenesis /
Required for the synthesis of the phthiocerol dimycocerosates and related compou...
Community Requests
3E53
44.8%
Mycobacterium tuberculosis
IDP91649
(
show subtarget assignments
)
8
cloned
No
NP_217311
15609932
hypothetical protein Rv2795c [Mycobacter...
324
drug target /
Confirmed essential by targeted genetic disruption and complementation studies, ...
Community Requests
Mycobacterium tuberculosis
IDP91650
(
show subtarget assignments
)
8
cloned
No
NP_216898
15609519
polyketide synthetase MBTC (polyketide s...
444
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
2QO3
47.1%
Mycobacterium tuberculosis
IDP91651
(
show subtarget assignments
)
8
cloned
No
NP_216894
15609515
lysine-N-oxygenase MBTG (L-lysine 6-mono...
431
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
Mycobacterium tuberculosis
IDP91680
(
show subtarget assignments
)
8
cloned
No
INLB_LISMO
0
630
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1M9S
93.7%
Listeria monocytogenes
IDP91780
(
show subtarget assignments
)
8
cloned
No
CAA27977
48190
unnamed protein product [Enterococcus fa...
639
drug resistance /
Tetracycline resistance
Community Requests
1DAR
28.4%
Enterococcus faecalis
IDP91816
(
show subtarget assignments
)
8
cloned
No
b2463
1788806
maeB
fused malic enzyme predicted oxidoreduct...
759
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1WW8
26.5%
Escherichia coli
IDP91817
(
show subtarget assignments
)
8
cloned
No
b2217
1788546
rcsB
DNA-binding response regulator in two-co...
216
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1P4W
36.6%
Escherichia coli
IDP91818
(
show subtarget assignments
)
8
cloned
No
b2584
1788938
yfiQ
inhibiting acetyltransferase for acetyl-...
886
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
2CSU
17.3%
Escherichia coli
IDP91824
(
show subtarget assignments
)
8
cloned
No
b1676
1787965
pykF
pyruvate kinase I [Escherichia coli str....
470
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1PKY
99.8%
Escherichia coli
IDP91832
(
show subtarget assignments
)
8
cloned
No
SMU.61
24378588
putative transcriptional regulator [Stre...
304
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus mutans
IDP91832
(
show subtarget assignments
)
8
cloned
No
SMU.61
24378588
putative transcriptional regulator [Stre...
304
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus mutans
IDP91842
(
show subtarget assignments
)
8
cloned
No
SPG_1268
194397142
positive transcriptional regulator MutRf...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91844
(
show subtarget assignments
)
8
cloned
No
SAK_1520
76787405
Rgg/GadR/MutR family transcriptional reg...
282
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus agalactiae
IDP91850
(
show subtarget assignments
)
8
cloned
No
SMU.1509
24379899
rgg
putative transcriptional regulator [Stre...
285
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus mutans
IDP91858
(
show subtarget assignments
)
8
cloned
No
NP_734518
25010123
hypothetical protein gbs0048 [Streptococ...
300
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus agalactiae
IDP91859
(
show subtarget assignments
)
8
cloned
No
SAK_0081
76788347
DNA-binding protein [Streptococcus agala...
302
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus agalactiae
IDP91860
(
show subtarget assignments
)
8
cloned
No
SAG0048
22536233
Cro/CI family transcriptional regulator ...
303
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus agalactiae
IDP91874
(
show subtarget assignments
)
8
cloned
No
SA0006
15925711
gyrA
DNA gyrase subunit A [Staphylococcus aur...
889
drug target /
Achillion Pharmaceuticals is interested in obtaining crystal structural data by ...
Community Requests
2XCO
55.1%
Staphylococcus aureus
IDP91953
(
show subtarget assignments
)
8
cloned
No
SpneCM_010100002215
298254414
extracellular solute-binding lipoprotein...
442
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3QUF
20.6%
Streptococcus pneumoniae
IDP91965
(
show subtarget assignments
)
8
cloned
No
SpneCM_010100004182
298254799
pneumococcal surface protein, putative [...
292
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2WW5
27.4%
Streptococcus pneumoniae
IDP91985
(
show subtarget assignments
)
8
cloned
No
SpneCM_010100007069
298255345
collagen adhesion protein [Streptococcus...
171
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP04181
(
show subtarget assignments
)
1
crystallized
No
VCA0197
9657589
GMP reductase [Vibrio cholerae O1 biovar...
347
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2A7R
63.4%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Nucleotide and nucleoside interconversions
IDP02139
(
show subtarget assignments
)
1
crystallized
No
GBAA4009
47529302
gmk
guanylate kinase [Bacillus anthracis str...
205
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3TAU
63.9%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides
Nucleotide and nucleoside interconversions
IDP01943
(
show subtarget assignments
)
1
crystallized
No
Cj1425c
15792743
putative sugar kinase [Campylobacter jej...
339
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
3K85
48.7%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP01659
(
show subtarget assignments
)
1
crystallized
No
CBU_1739
29542296
tetrapyrrole (Corrin/Porphyrin) methylas...
285
Conserved; Drug target functions
Phase 3: June 2008
3KWP
42.1%
Coxiella burnetii
Unknown function
General
IDP91188
(
show subtarget assignments
)
1
crystallized
No
CAA24743
40923
unnamed protein product [Escherichia col...
341
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OVC
100%
Escherichia coli
IDP02277
(
show subtarget assignments
)
1
crystallized
No
GBAA1434
47526709
glycerate dehydrogenase [Bacillus anthra...
323
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2DBQ
48.6%
Bacillus anthracis
Central intermediary metabolism
Other
IDP90721
(
show subtarget assignments
)
8
crystallized
No
YPO1610
16121878
aroE
shikimate 5-dehydrogenase [Yersinia pest...
292
Predicted Essential
Community Requests
1NPY
52.4%
Yersinia pestis
IDP04177
(
show subtarget assignments
)
1
crystallized
No
VC2629
9657219
shikimate kinase [Vibrio cholerae O1 bio...
174
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1KAG
81%
Vibrio cholerae
Amino acid biosynthesis
Aromatic amino acid family
IDP00259
(
show subtarget assignments
)
1
crystallized
No
CPXV018
30844336
CPXV229 CDS
OMCP protein Cowpox virus
171
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
Cowpox virus
IDP04127
(
show subtarget assignments
)
1
crystallized
No
YPO2889
115348559
pepB
peptidase B [Yersinia pestis CO92]
432
drug target; putative drug target function;
Phase 4: April 2009
1BLL
32.9%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01204
(
show subtarget assignments
)
1
crystallized
No
BA_2274
30256914
glycosyl transferase, group 2 family pro...
406
Essential Gene
Phase 2: March 2008
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00090
(
show subtarget assignments
)
1
crystallized
No
NT01SF0319
30040101
crl
transcriptional regulator of cryptic csg...
133
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3RPJ
45.9%
Shigella flexneri
Cell envelope
Surface structures
IDP00210
(
show subtarget assignments
)
1
crystallized
No
YPO0314
16120652
lexA
LexA repressor
202
Virulence
Phase 1: October 2007
1JHF
91.1%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP04124
(
show subtarget assignments
)
1
crystallized
No
YPO2828
218929893
purI
phosphoribosylaminoimidazole synthetase ...
347
conserved gene; putative drug target function;
Phase 4: April 2009
1CLI
81.6%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
Purine ribonucleotide biosynthesis
IDP00418
(
show subtarget assignments
)
1
crystallized
No
YPO0910
16121215
pepP
proline aminopeptidase P II
437
Drug Target Function
Phase 2: March 2008
1A16
81.2%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP04119
(
show subtarget assignments
)
1
crystallized
No
BAS0131
49183165
adenylate kinase [Bacillus anthracis str...
216
Proposed to be essential proteins
Phase 4: April 2009
1ZIN
74.1%
Bacillus anthracis
IDP04109
(
show subtarget assignments
)
1
crystallized
No
GBAA3100
47528393
copper homeostasis protein CutC, putativ...
225
virulence factor; putative drug target function;
Phase 4: April 2009
2BDQ
30.7%
Bacillus anthracis
Transport and binding proteins
Cations and iron carrying compounds
IDP04090
(
show subtarget assignments
)
1
crystallized
No
CPF_0694
110800453
aroK
shikimate kinase [Clostridium perfringen...
167
conserved gene; putative drug target function;
Phase 4: April 2009
2PT5
34.1%
Clostridium perfringens
Amino acid biosynthesis
Aromatic amino acid family
IDP90710
(
show subtarget assignments
)
8
crystallized
No
Cj0451
15791815
rep
ribulose-phosphate 3-epimerase [Campylob...
215
Predicted Essential
Community Requests
1RPX
48.4%
Campylobacter jejuni
IDP04077
(
show subtarget assignments
)
1
crystallized
No
FTT1793c
56708781
pepN
aminopeptidase N [Francisella tularensis...
864
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2DQ6
48.9%
Francisella tularensis
IDP04073
(
show subtarget assignments
)
1
crystallized
No
YPO0502
115346311
conserved hypothetical protein [Yersinia...
172
virulence factor; conserved gene;
Phase 4: April 2009
1Y12
38.4%
Yersinia pestis
Hypothetical proteins
Conserved
IDP01707
(
show subtarget assignments
)
1
crystallized
No
STM1631
16764975
sseJ
secreted effector protein [Salmonella ty...
408
VIRULENCE FACTOR
Phase 3: June 2008
3CXB
10%
Salmonella enterica
N/A
N/A
IDP02836
(
show subtarget assignments
)
1
crystallized
No
GBAA4423
47529716
aroQ
3-dehydroquinate dehydratase [Bacillus a...
146
Conserved; Drug target functions
Phase 3: June 2008
1GQO
57.5%
Bacillus anthracis
Amino acid biosynthesis
Aromatic amino acid family
IDP02831
(
show subtarget assignments
)
1
crystallized
No
GBAA4686
47529986
maf
Maf-like protein [Bacillus anthracis str...
191
Conserved; Drug target functions
Phase 3: June 2008
1EX2
53.4%
Bacillus anthracis
Cellular processes
Cell division
IDP01211
(
show subtarget assignments
)
1
crystallized
No
BA_2958
30257549
chorismate mutase/phospho-2-dehydro-3-de...
358
Drug Target Function
Phase 2: March 2008
3NVT
69.8%
Bacillus anthracis
Amino acid biosynthesis
Aromatic amino acid family
IDP90987
(
show subtarget assignments
)
8
crystallized
No
y1125
22125029
hypothetical protein y1125 [Yersinia pes...
297
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
1VP5
57.2%
Yersinia pestis
IDP02068
(
show subtarget assignments
)
1
crystallized
No
YPO3194
16123356
ahpC
putative alkyl hydroperoxide reductase s...
200
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1ZOF
59%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP00073
(
show subtarget assignments
)
1
crystallized
No
NT01ST3324
16421221
rimM
16S rRNA processing protein
182
Essential
Phase 1: October 2007
3H9N
63.2%
Salmonella enterica
Unclassified
Role category not yet assigned
IDP02773
(
show subtarget assignments
)
1
crystallized
No
FTT1389
56708438
panB
3-methyl-2-oxobutanoate hydroxymethyltra...
264
Conserved; Drug target functions
Phase 3: June 2008
1O66
41.7%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Pantothenate and coenzyme A
IDP02752
(
show subtarget assignments
)
1
crystallized
No
FTT0650c
56707772
grxB
glutaredoxin 2 [Francisella tularensis s...
214
Drug Target
Phase 3: June 2008
3IR4
30.4%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Glutathione and analogs
IDP02727
(
show subtarget assignments
)
1
crystallized
No
GBAA4249
47778264
3-hydroxybutyrate dehydrogenase [Bacillu...
258
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
3V2H
42.6%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP02725
(
show subtarget assignments
)
1
crystallized
No
GBAA4341
47529638
bioA
adenosylmethionine--8-amino-7-oxononanoa...
462
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3DOD
57.1%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP02703
(
show subtarget assignments
)
1
crystallized
No
GBAA3432
47528718
tkt-1
transketolase [Bacillus anthracis str. '...
674
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HYL
58.1%
Bacillus anthracis
Energy metabolism
Pentose phosphate pathway
IDP90934
(
show subtarget assignments
)
8
crystallized
No
YPO0480
16120810
dapB
dihydrodipicolinate reductase [Yersinia ...
273
Predicted Essential
Community Requests
1ARZ
79.5%
Yersinia pestis
IDP02693
(
show subtarget assignments
)
1
crystallized
No
FTT0185
56707350
ddlB
D-alanine--D-alanine ligase B [Francisel...
296
Conserved; Drug target functions
Phase 3: June 2008
3V4Z
43.9%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02676
(
show subtarget assignments
)
1
crystallized
No
GBAA1539
47526813
hisC-1
histidinol-phosphate aminotransferase [B...
370
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3FFH
46.2%
Bacillus anthracis
Amino acid biosynthesis
Histidine family
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