Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05500 (show subtarget assignments)	1	cloned	No	CD0261	126697833	fliQ	flagellar export protein [Clostridium di...	89	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05501 (show subtarget assignments)	1	in_crystallization_trials	No	CD0270	126697842	fliM	putative flagellar motor switch protein ...	293	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HP7	15.7%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05502 (show subtarget assignments)	1	cloned	No	CD0386	126697956		putative collagen-binding surface protei...	1014	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP05497 (show subtarget assignments)	1	cloned	No	CD0241	126697812		phosphoserine phosphatase [Clostridium d...	205	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5S	32.1%	Clostridium difficile	Amino acid biosynthesis: Serine family

IDP05498 (show subtarget assignments)	1	cloned	No	CD0249	126697820	fliG	flagellar motor switch protein [Clostrid...	356	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3PKR	28.4%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05494 (show subtarget assignments)	1	soluble	No	CD0234	126697805	csrA	carbon storage regulator [Clostridium di...	70	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1T3O	47.1%	Clostridium difficile	Regulatory functions: RNA interactions

IDP05495 (show subtarget assignments)	1	cloned	No	CD0237	126697808	fliD	flagellar cap protein [Clostridium diffi...	507	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05295 (show subtarget assignments)	1	cloned	No	CD1816	126699424	cmk	cytidylate kinase [Clostridium difficile...	216	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Q3T	44.4%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05493 (show subtarget assignments)	1	cloned	No	CD0231	126697802	flgK	putative flagellar hook-associated prote...	436	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05524 (show subtarget assignments)	1	cloned	No	CD2402	126700017		putative cell wall hydrolase [Clostridiu...	396	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3H41	20.5%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP05296 (show subtarget assignments)	1	purified	No	CD2138	126699755	pyrH	uridylate kinase [Clostridium difficile ...	234	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Z9D	59.1%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05292 (show subtarget assignments)	1	cloned	No	CD1600	126699204	thiK	hydroxyethylthiazole kinase [Clostridium...	262	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3HPD	35.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05293 (show subtarget assignments)	1	cloned	No	CD1408	126699011	ddl	D-alanine--D-alanine ligase [Clostridium...	299	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3R23	51.5%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05291 (show subtarget assignments)	1	in_crystallization_trials	No	CD1211	126698807		putative acetyltransferase [Clostridium ...	163	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	1YX0	23.9%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP05294 (show subtarget assignments)	1	cloned	No	CD1418	126699021		putative drug/sodium antiporter [Clostri...	451	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3MKT	20.6%	Clostridium difficile	Transport and binding proteins: Other

IDP05290 (show subtarget assignments)	1	cloned	No	CD0488	126698065	sugE	quaternary ammonium compound-resistance ...	106	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2I68	30.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP05340 (show subtarget assignments)	1	in_pdb 3UUW	Yes	CD3450	126701073		putative oxidoreductase [Clostridium dif...	305	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3UUW	100%	Clostridium difficile	Cellular processes: Pathogenesis

IDP91082 (show subtarget assignments)	8	cloned	No	CPF_1776	110800219		ABC transporter, permease/ATP-binding pr...	589	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	39.2%	Clostridium perfringens

IDP04393 (show subtarget assignments)	1	cloned	No	CPF_1645	110798596	lonB	ATP-dependent protease LonB [Clostridium...	570	conserved gene; putative drug target function;	Phase 4: April 2009	3K1J	29.4%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04382 (show subtarget assignments)	1	expressed	No	CPF_0116	110801065		sensor histidine kinase [Clostridium per...	337	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17.8%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04378 (show subtarget assignments)	1	cloned	No	CPF_2335	110799804		extracellular solute-binding protein [Cl...	482	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04391 (show subtarget assignments)	1	cloned	No	CPF_1067	110798883	cotJB	spore coat protein CotJB [Clostridium pe...	83	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04392 (show subtarget assignments)	1	cloned	No	CPF_1500	110798925		putative lipoprotein [Clostridium perfri...	202	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04727 (show subtarget assignments)	1	purified	No	CPF_2072	110800396		hemolysin A [Clostridium perfringens ATC...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3HP7	49.8%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04376 (show subtarget assignments)	1	crystallized	No	CPF_2558	110800169	guaB	inositol-5-monophosphate dehydrogenase [...	484	conserved gene; putative drug target function;	Phase 4: April 2009	3TSB	67.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04394 (show subtarget assignments)	1	cloned	No	CPF_2117	110800208	spoVD	stage V sporulation protein D [Clostridi...	695	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	24.8%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04351 (show subtarget assignments)	1	cloned	No	CPF_1213	110799898	kdpD	sensor histidine kinase KdpD [Clostridiu...	900	conserved gene; putative drug target function;	Phase 4: April 2009	2R8R	12.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04377 (show subtarget assignments)	1	soluble	No	CPF_2652	110798678		putative maltose/maltodextrin ABC transp...	408	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1URG	38.7%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04337 (show subtarget assignments)	1	cloned	No	CPF_0720	110801161	splB	spore photoproduct lyase [Clostridium pe...	340	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04338 (show subtarget assignments)	1	cloned	No	CPF_1446	110801179	sodF	Mn/Fe superoxide dismutase [Clostridium ...	227	conserved gene; putative drug target function;	Phase 4: April 2009	1JR9	44.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04330 (show subtarget assignments)	1	soluble	No	CPF_2086	110799751		stage III sporulation protein SpoAB [Clo...	171	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04331 (show subtarget assignments)	1	purified	No	CPF_2181	110799592		sensor histidine kinase [Clostridium per...	507	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.4%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04365 (show subtarget assignments)	1	cloned	No	CPF_1523	110798905		sensory box histidine kinase [Clostridiu...	787	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	11.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04405 (show subtarget assignments)	1	cloned	No	CPF_2987	110799346		stage 0 sporulation protein J [Clostridi...	286	conserved gene; putative drug target function;	Phase 4: April 2009	1VZ0	33.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04403 (show subtarget assignments)	1	cloned	No	CPF_0630	110801303		spore germination protein [Clostridium p...	374	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N54	17.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04324 (show subtarget assignments)	1	purified	No	CPF_2814	110799621		regulatory protein SpoVG [Clostridium pe...	90	conserved gene; putative drug target function;	Phase 4: April 2009	2IA9	55.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04329 (show subtarget assignments)	1	expressed	No	CPF_1466	110801108		putative lipoprotein [Clostridium perfri...	483	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04347 (show subtarget assignments)	1	expressed	No	CPF_2345	110801165		sensor histidine kinase [Clostridium per...	578	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04307 (show subtarget assignments)	1	cloned	No	CPF_1812	110799901		putative lipoprotein [Clostridium perfri...	44	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens

IDP04305 (show subtarget assignments)	1	cloned	No	CPF_2386	110798631		ribonuclease [Clostridium perfringens AT...	480	conserved gene; putative drug target function;	Phase 4: April 2009	2BX2	27.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04303 (show subtarget assignments)	1	cloned	No	CPF_0251	110800905	lacA	galactoside O-acetyltransferase [Clostri...	204	conserved gene; putative drug target function;	Phase 4: April 2009	1KQA	51%	Clostridium perfringens	Cellular processes	Detoxification

IDP04302 (show subtarget assignments)	1	soluble	No	CPF_2503	110801437		sensor histidine kinase [Clostridium per...	471	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.6%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04304 (show subtarget assignments)	1	cloned	No	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04300 (show subtarget assignments)	1	purified	No	CPF_0672	110798984	purE	phosphoribosylaminoimidazole carboxylase...	159	conserved gene; putative drug target function;	Phase 4: April 2009	1O4V	51.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04301 (show subtarget assignments)	1	soluble	No	CPF_2400	110800698	maf	Maf-like protein [Clostridium perfringen...	192	conserved gene; putative drug target function;	Phase 4: April 2009	2P5X	44.4%	Clostridium perfringens	Cellular processes	Cell division

IDP04348 (show subtarget assignments)	1	cloned	No	CPF_2547	110801206		two component regulator [Clostridium per...	686	viruelnce factor;	Phase 4: April 2009			Clostridium perfringens	Unknown function	General

IDP04267 (show subtarget assignments)	1	cloned	No	CPF_2134	110799922	spoVD	stage V sporulation protein D [Clostridi...	727	conserved gene; putative drug target function;	Phase 4: April 2009	1RP5	26.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04268 (show subtarget assignments)	1	soluble	No	CPF_2184	110799943	glyA	serine hydroxymethyltransferase [Clostri...	410	conserved gene; putative drug target function;	Phase 4: April 2009	3PGY	68.3%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04270 (show subtarget assignments)	1	cloned	No	CPF_2226	110799081	potD	spermidine/putrescine ABC transporter, s...	360	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EQB	40.3%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04263 (show subtarget assignments)	1	cloned	No	CPF_2068	110800995		stage IV sporulation protein B [Clostrid...	386	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04264 (show subtarget assignments)	1	cloned	No	CPF_2101	110800507		fibronectin-binding protein [Clostridium...	575	conserved gene; putative drug target function;	Phase 4: April 2009	3DOA	17.7%	Clostridium perfringens	Cellular processes

IDP04271 (show subtarget assignments)	1	expressed	No	CPF_2241	110798635		sensor histidine kinase [Clostridium per...	678	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	12.4%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04265 (show subtarget assignments)	1	purified	No	CPF_2105	110800754		putative cell division protein DivIVA [C...	208	conserved gene; putative drug target function;	Phase 4: April 2009	2WUJ	12%	Clostridium perfringens	Cellular processes	Cell division

IDP04366 (show subtarget assignments)	1	purified	No	CPF_1531	110800274		amino acid ABC transporter, amino acid-b...	262	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HV1	36.6%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04259 (show subtarget assignments)	1	cloned	No	CPF_2018	110799691	ftsZ	cell division protein FtsZ [Clostridium ...	381	conserved gene; putative drug target function;	Phase 4: April 2009	2VAM	58%	Clostridium perfringens	Cellular processes	Cell division

IDP04260 (show subtarget assignments)	1	cloned	No	CPF_2020	110798885	pilT	twitching motility protein PilT [Clostri...	350	conserved gene; putative drug target function;	Phase 4: April 2009	2EWV	49.1%	Clostridium perfringens	Cellular processes	Chemotaxis and motility

IDP04258 (show subtarget assignments)	1	soluble	No	CPF_2010	110801347		sensory box histidine kinase [Clostridiu...	571	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	17.3%	Clostridium perfringens	Regulatory functions

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04407 (show subtarget assignments)	1	cloned	No	CPF_0677	110799553	purH	bifunctional phosphoribosylaminoimidazol...	501	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	41.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04262 (show subtarget assignments)	1	cloned	No	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04251 (show subtarget assignments)	1	cloned	No	CPF_1751	110801372	virS	sensor histidine kinase VirS [Clostridiu...	440	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04252 (show subtarget assignments)	1	cloned	No	CPF_1780	110799805		putative lipoprotein [Clostridium perfri...	445	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04253 (show subtarget assignments)	1	purified	No	CPF_1800	110800480	prs	phosphoribosylpyrophosphate synthetase [...	364	conserved gene; putative drug target function;	Phase 4: April 2009	2C4K	25.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04247 (show subtarget assignments)	1	expressed	No	CPF_1402	110798994		sensor histidine kinase [Clostridium per...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.3%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04248 (show subtarget assignments)	1	in_pdb 4EDP	No	CPF_1477	110800354		ABC transporter, substrate-binding prote...	348	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EDP	100%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04249 (show subtarget assignments)	1	expressed	No	CPF_1548	110800969		putative galactoside ABC transporter, ga...	354	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GLG	50.6%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04254 (show subtarget assignments)	1	cloned	No	CPF_1823	110798846		putative lipoprotein [Clostridium perfri...	233	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04243 (show subtarget assignments)	1	soluble	No	CPF_1140	110799522		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04244 (show subtarget assignments)	1	soluble	No	CPF_1171	110801284		sensor histidine kinase [Clostridium per...	410	conserved gene; putative drug target function;	Phase 4: April 2009	1B3Q	9.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04245 (show subtarget assignments)	1	cloned	No	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04240 (show subtarget assignments)	1	cloned	No	CPF_1077	110800997		extracellular solute-binding protein [Cl...	477	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W7Y	15.3%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04241 (show subtarget assignments)	1	soluble	No	CPF_1112	110801022		sensor histidine kinase [Clostridium per...	574	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Regulatory functions	Protein interactions

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04235 (show subtarget assignments)	1	cloned	No	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04236 (show subtarget assignments)	1	expressed	No	CPF_0837	110799475		sensor histidine kinase [Clostridium per...	336	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04237 (show subtarget assignments)	1	purified	No	CPF_0863	110800564		putative sensor histidine kinase [Clostr...	420	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04238 (show subtarget assignments)	1	cloned	No	CPF_0889	110799788		sensor histidine kinase [Clostridium per...	475	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04234 (show subtarget assignments)	1	cloned	No	CPF_0807	110799166		iron compound ABC transporter, iron comp...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HXP	29.3%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04232 (show subtarget assignments)	1	cloned	No	CPF_0693	110799915	aroE	shikimate 5-dehydrogenase [Clostridium p...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3FBT	46.9%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04233 (show subtarget assignments)	1	cloned	No	CPF_0722	110798767		putative lipoprotein [Clostridium perfri...	384	drug target; putative drug target function;	Phase 4: April 2009	2UVK	16.1%	Clostridium perfringens	Cell envelope	Other

IDP04239 (show subtarget assignments)	1	cloned	No	CPF_1057	110799811		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.4%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04227 (show subtarget assignments)	1	expressed	No	CPF_0198	110799765		sensory box histidine kinase [Clostridiu...	791	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.6%	Clostridium perfringens	Regulatory functions

IDP04228 (show subtarget assignments)	1	cloned	No	CPF_0675	110800755	purM	phosphoribosylaminoimidazole synthetase ...	333	conserved gene; putative drug target function;	Phase 4: April 2009	2BTU	54.9%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04229 (show subtarget assignments)	1	purified	No	CPF_0676	110798651	purN	phosphoribosylglycinamide formyltransfer...	204	conserved gene; putative drug target function;	Phase 4: April 2009	2YWR	42.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04226 (show subtarget assignments)	1	cloned	No	CPF_0171	110799571	luxS	S-ribosylhomocysteinase [Clostridium per...	151	conserved gene; putative drug target function;	Phase 4: April 2009	1J6W	51%	Clostridium perfringens	Cellular processes	Other

IDP04256 (show subtarget assignments)	1	purified	No	CPF_2006	110801043	spoIVA	stage IV sporulation protein A [Clostrid...	491	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP04230 (show subtarget assignments)	1	purified	No	CPF_0678	110801134	purD	phosphoribosylamine--glycine ligase [Clo...	416	conserved gene; putative drug target function;	Phase 4: April 2009	2YW2	51.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04208 (show subtarget assignments)	1	purified	No	CPF_2958	110799195	purA	adenylosuccinate synthetase [Clostridium...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1IWE	47.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04203 (show subtarget assignments)	1	selected	No	CPF_2298	110800865	gpr	germination protease [Clostridium perfri...	325	conserved gene; putative drug target function;	Phase 4: April 2009	1C8B	42.3%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04204 (show subtarget assignments)	1	soluble	No	CPF_2382	110799414	obgE	GTPase ObgE [Clostridium perfringens ATC...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1LNZ	44.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05500
(show subtarget assignments)

1

cloned

No

CD0261

126697833

fliQ

flagellar export protein [Clostridium di...

89

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05501
(show subtarget assignments)

1

in_crystallization_trials

No

CD0270

126697842

fliM

putative flagellar motor switch protein ...

293

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HP7

15.7%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05502
(show subtarget assignments)

1

cloned

No

CD0386

126697956

putative collagen-binding surface protei...

1014

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP05497
(show subtarget assignments)

1

cloned

No

CD0241

126697812

phosphoserine phosphatase [Clostridium d...

205

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5S

32.1%

Clostridium difficile

Amino acid biosynthesis: Serine family

IDP05498
(show subtarget assignments)

1

cloned

No

CD0249

126697820

fliG

flagellar motor switch protein [Clostrid...

356

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3PKR

28.4%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05494
(show subtarget assignments)

1

soluble

No

CD0234

126697805

csrA

carbon storage regulator [Clostridium di...

70

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1T3O

47.1%

Clostridium difficile

Regulatory functions: RNA interactions

IDP05495
(show subtarget assignments)

1

cloned

No

CD0237

126697808

fliD

flagellar cap protein [Clostridium diffi...

507

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05295
(show subtarget assignments)

1

cloned

No

CD1816

126699424

cmk

cytidylate kinase [Clostridium difficile...

216

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Q3T

44.4%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05493
(show subtarget assignments)

1

cloned

No

CD0231

126697802

flgK

putative flagellar hook-associated prote...

436

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05524
(show subtarget assignments)

1

cloned

No

CD2402

126700017

putative cell wall hydrolase [Clostridiu...

396

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3H41

20.5%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP05296
(show subtarget assignments)

1

purified

No

CD2138

126699755

pyrH

uridylate kinase [Clostridium difficile ...

234

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Z9D

59.1%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05292
(show subtarget assignments)

1

cloned

No

CD1600

126699204

thiK

hydroxyethylthiazole kinase [Clostridium...

262

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3HPD

35.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05293
(show subtarget assignments)

1

cloned

No

CD1408

126699011

ddl

D-alanine--D-alanine ligase [Clostridium...

299

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3R23

51.5%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05291
(show subtarget assignments)

1

in_crystallization_trials

No

CD1211

126698807

putative acetyltransferase [Clostridium ...

163

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

1YX0

23.9%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP05294
(show subtarget assignments)

1

cloned

No

CD1418

126699021

putative drug/sodium antiporter [Clostri...

451

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3MKT

20.6%

Clostridium difficile

Transport and binding proteins: Other

IDP05290
(show subtarget assignments)

1

cloned

No

CD0488

126698065

sugE

quaternary ammonium compound-resistance ...

106

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2I68

30.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP05340
(show subtarget assignments)

1

in_pdb
3UUW

Yes

CD3450

126701073

putative oxidoreductase [Clostridium dif...

305

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3UUW

100%

Clostridium difficile

Cellular processes: Pathogenesis

IDP91082
(show subtarget assignments)

8

cloned

No

CPF_1776

110800219

ABC transporter, permease/ATP-binding pr...

589

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

39.2%

Clostridium perfringens

IDP04393
(show subtarget assignments)

1

cloned

No

CPF_1645

110798596

lonB

ATP-dependent protease LonB [Clostridium...

570

conserved gene; putative drug target function;

Phase 4: April 2009

3K1J

29.4%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04382
(show subtarget assignments)

1

expressed

No

CPF_0116

110801065

sensor histidine kinase [Clostridium per...

337

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17.8%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04378
(show subtarget assignments)

1

cloned

No

CPF_2335

110799804

extracellular solute-binding protein [Cl...

482

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04391
(show subtarget assignments)

1

cloned

No

CPF_1067

110798883

cotJB

spore coat protein CotJB [Clostridium pe...

83

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04392
(show subtarget assignments)

1

cloned

No

CPF_1500

110798925

putative lipoprotein [Clostridium perfri...

202

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04727
(show subtarget assignments)

1

purified

No

CPF_2072

110800396

hemolysin A [Clostridium perfringens ATC...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3HP7

49.8%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04376
(show subtarget assignments)

1

crystallized

No

CPF_2558

110800169

guaB

inositol-5-monophosphate dehydrogenase [...

484

conserved gene; putative drug target function;

Phase 4: April 2009

3TSB

67.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04394
(show subtarget assignments)

1

cloned

No

CPF_2117

110800208

spoVD

stage V sporulation protein D [Clostridi...

695

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

24.8%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04351
(show subtarget assignments)

1

cloned

No

CPF_1213

110799898

kdpD

sensor histidine kinase KdpD [Clostridiu...

900

conserved gene; putative drug target function;

Phase 4: April 2009

2R8R

12.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04377
(show subtarget assignments)

1

soluble

No

CPF_2652

110798678

putative maltose/maltodextrin ABC transp...

408

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1URG

38.7%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04337
(show subtarget assignments)

1

cloned

No

CPF_0720

110801161

splB

spore photoproduct lyase [Clostridium pe...

340

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04338
(show subtarget assignments)

1

cloned

No

CPF_1446

110801179

sodF

Mn/Fe superoxide dismutase [Clostridium ...

227

conserved gene; putative drug target function;

Phase 4: April 2009

1JR9

44.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04330
(show subtarget assignments)

1

soluble

No

CPF_2086

110799751

stage III sporulation protein SpoAB [Clo...

171

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04331
(show subtarget assignments)

1

purified

No

CPF_2181

110799592

sensor histidine kinase [Clostridium per...

507

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.4%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04365
(show subtarget assignments)

1

cloned

No

CPF_1523

110798905

sensory box histidine kinase [Clostridiu...

787

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

11.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04405
(show subtarget assignments)

1

cloned

No

CPF_2987

110799346

stage 0 sporulation protein J [Clostridi...

286

conserved gene; putative drug target function;

Phase 4: April 2009

1VZ0

33.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04403
(show subtarget assignments)

1

cloned

No

CPF_0630

110801303

spore germination protein [Clostridium p...

374

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N54

17.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04324
(show subtarget assignments)

1

purified

No

CPF_2814

110799621

regulatory protein SpoVG [Clostridium pe...

90

conserved gene; putative drug target function;

Phase 4: April 2009

2IA9

55.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04329
(show subtarget assignments)

1

expressed

No

CPF_1466

110801108

putative lipoprotein [Clostridium perfri...

483

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04347
(show subtarget assignments)

1

expressed

No

CPF_2345

110801165

sensor histidine kinase [Clostridium per...

578

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04307
(show subtarget assignments)

1

cloned

No

CPF_1812

110799901

putative lipoprotein [Clostridium perfri...

44

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

IDP04305
(show subtarget assignments)

1

cloned

No

CPF_2386

110798631

ribonuclease [Clostridium perfringens AT...

480

conserved gene; putative drug target function;

Phase 4: April 2009

2BX2

27.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04303
(show subtarget assignments)

1

cloned

No

CPF_0251

110800905

lacA

galactoside O-acetyltransferase [Clostri...

204

conserved gene; putative drug target function;

Phase 4: April 2009

1KQA

51%

Clostridium perfringens

Cellular processes

Detoxification

IDP04302
(show subtarget assignments)

1

soluble

No

CPF_2503

110801437

sensor histidine kinase [Clostridium per...

471

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.6%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04304
(show subtarget assignments)

1

cloned

No

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04300
(show subtarget assignments)

1

purified

No

CPF_0672

110798984

purE

phosphoribosylaminoimidazole carboxylase...

159

conserved gene; putative drug target function;

Phase 4: April 2009

1O4V

51.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04301
(show subtarget assignments)

1

soluble

No

CPF_2400

110800698

maf

Maf-like protein [Clostridium perfringen...

192

conserved gene; putative drug target function;

Phase 4: April 2009

2P5X

44.4%

Clostridium perfringens

Cellular processes

Cell division

IDP04348
(show subtarget assignments)

1

cloned

No

CPF_2547

110801206

two component regulator [Clostridium per...

686

viruelnce factor;

Phase 4: April 2009

Clostridium perfringens

Unknown function

General

IDP04267
(show subtarget assignments)

1

cloned

No

CPF_2134

110799922

spoVD

stage V sporulation protein D [Clostridi...

727

conserved gene; putative drug target function;

Phase 4: April 2009

1RP5

26.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04268
(show subtarget assignments)

1

soluble

No

CPF_2184

110799943

glyA

serine hydroxymethyltransferase [Clostri...

410

conserved gene; putative drug target function;

Phase 4: April 2009

3PGY

68.3%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04270
(show subtarget assignments)

1

cloned

No

CPF_2226

110799081

potD

spermidine/putrescine ABC transporter, s...

360

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EQB

40.3%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04263
(show subtarget assignments)

1

cloned

No

CPF_2068

110800995

stage IV sporulation protein B [Clostrid...

386

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04264
(show subtarget assignments)

1

cloned

No

CPF_2101

110800507

fibronectin-binding protein [Clostridium...

575

conserved gene; putative drug target function;

Phase 4: April 2009

3DOA

17.7%

Clostridium perfringens

Cellular processes

IDP04271
(show subtarget assignments)

1

expressed

No

CPF_2241

110798635

sensor histidine kinase [Clostridium per...

678

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

12.4%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04265
(show subtarget assignments)

1

purified

No

CPF_2105

110800754

putative cell division protein DivIVA [C...

208

conserved gene; putative drug target function;

Phase 4: April 2009

2WUJ

12%

Clostridium perfringens

Cellular processes

Cell division

IDP04366
(show subtarget assignments)

1

purified

No

CPF_1531

110800274

amino acid ABC transporter, amino acid-b...

262

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HV1

36.6%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04259
(show subtarget assignments)

1

cloned

No

CPF_2018

110799691

ftsZ

cell division protein FtsZ [Clostridium ...

381

conserved gene; putative drug target function;

Phase 4: April 2009

2VAM

58%

Clostridium perfringens

Cellular processes

Cell division

IDP04260
(show subtarget assignments)

1

cloned

No

CPF_2020

110798885

pilT

twitching motility protein PilT [Clostri...

350

conserved gene; putative drug target function;

Phase 4: April 2009

2EWV

49.1%

Clostridium perfringens

Cellular processes

Chemotaxis and motility

IDP04258
(show subtarget assignments)

1

soluble

No

CPF_2010

110801347

sensory box histidine kinase [Clostridiu...

571

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

17.3%

Clostridium perfringens

Regulatory functions

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04407
(show subtarget assignments)

1

cloned

No

CPF_0677

110799553

purH

bifunctional phosphoribosylaminoimidazol...

501

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

41.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04262
(show subtarget assignments)

1

cloned

No

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04251
(show subtarget assignments)

1

cloned

No

CPF_1751

110801372

virS

sensor histidine kinase VirS [Clostridiu...

440

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04252
(show subtarget assignments)

1

cloned

No

CPF_1780

110799805

putative lipoprotein [Clostridium perfri...

445

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04253
(show subtarget assignments)

1

purified

No

CPF_1800

110800480

prs

phosphoribosylpyrophosphate synthetase [...

364

conserved gene; putative drug target function;

Phase 4: April 2009

2C4K

25.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04247
(show subtarget assignments)

1

expressed

No

CPF_1402

110798994

sensor histidine kinase [Clostridium per...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.3%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04248
(show subtarget assignments)

1

in_pdb
4EDP

No

CPF_1477

110800354

ABC transporter, substrate-binding prote...

348

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EDP

100%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04249
(show subtarget assignments)

1

expressed

No

CPF_1548

110800969

putative galactoside ABC transporter, ga...

354

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GLG

50.6%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04254
(show subtarget assignments)

1

cloned

No

CPF_1823

110798846

putative lipoprotein [Clostridium perfri...

233

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04243
(show subtarget assignments)

1

soluble

No

CPF_1140

110799522

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04244
(show subtarget assignments)

1

soluble

No

CPF_1171

110801284

sensor histidine kinase [Clostridium per...

410

conserved gene; putative drug target function;

Phase 4: April 2009

1B3Q

9.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04245
(show subtarget assignments)

1

cloned

No

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04240
(show subtarget assignments)

1

cloned

No

CPF_1077

110800997

extracellular solute-binding protein [Cl...

477

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W7Y

15.3%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04241
(show subtarget assignments)

1

soluble

No

CPF_1112

110801022

sensor histidine kinase [Clostridium per...

574

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04235
(show subtarget assignments)

1

cloned

No

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04236
(show subtarget assignments)

1

expressed

No

CPF_0837

110799475

sensor histidine kinase [Clostridium per...

336

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04237
(show subtarget assignments)

1

purified

No

CPF_0863

110800564

putative sensor histidine kinase [Clostr...

420

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04238
(show subtarget assignments)

1

cloned

No

CPF_0889

110799788

sensor histidine kinase [Clostridium per...

475

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04234
(show subtarget assignments)

1

cloned

No

CPF_0807

110799166

iron compound ABC transporter, iron comp...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HXP

29.3%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04232
(show subtarget assignments)

1

cloned

No

CPF_0693

110799915

aroE

shikimate 5-dehydrogenase [Clostridium p...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3FBT

46.9%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04233
(show subtarget assignments)

1

cloned

No

CPF_0722

110798767

putative lipoprotein [Clostridium perfri...

384

drug target; putative drug target function;

Phase 4: April 2009

2UVK

16.1%

Clostridium perfringens

Cell envelope

Other

IDP04239
(show subtarget assignments)

1

cloned

No

CPF_1057

110799811

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.4%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04227
(show subtarget assignments)

1

expressed

No

CPF_0198

110799765

sensory box histidine kinase [Clostridiu...

791

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.6%

Clostridium perfringens

Regulatory functions

IDP04228
(show subtarget assignments)

1

cloned

No

CPF_0675

110800755

purM

phosphoribosylaminoimidazole synthetase ...

333

conserved gene; putative drug target function;

Phase 4: April 2009

2BTU

54.9%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04229
(show subtarget assignments)

1

purified

No

CPF_0676

110798651

purN

phosphoribosylglycinamide formyltransfer...

204

conserved gene; putative drug target function;

Phase 4: April 2009

2YWR

42.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04226
(show subtarget assignments)

1

cloned

No

CPF_0171

110799571

luxS

S-ribosylhomocysteinase [Clostridium per...

151

conserved gene; putative drug target function;

Phase 4: April 2009

1J6W

51%

Clostridium perfringens

Cellular processes

Other

IDP04256
(show subtarget assignments)

1

purified

No

CPF_2006

110801043

spoIVA

stage IV sporulation protein A [Clostrid...

491

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP04230
(show subtarget assignments)

1

purified

No

CPF_0678

110801134

purD

phosphoribosylamine--glycine ligase [Clo...

416

conserved gene; putative drug target function;

Phase 4: April 2009

2YW2

51.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04208
(show subtarget assignments)

1

purified

No

CPF_2958

110799195

purA

adenylosuccinate synthetase [Clostridium...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1IWE

47.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04203
(show subtarget assignments)

1

selected

No

CPF_2298

110800865

gpr

germination protease [Clostridium perfri...

325

conserved gene; putative drug target function;

Phase 4: April 2009

1C8B

42.3%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04204
(show subtarget assignments)

1

soluble

No

CPF_2382

110799414

obgE

GTPase ObgE [Clostridium perfringens ATC...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1LNZ

44.2%

Clostridium perfringens

Cellular processes

Sporulation and germination