Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02720 (show subtarget assignments)	1	cloned	No	GBAA3950	47529240	infB	translation initiation factor IF-2 [Baci...	686	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1ZO1	42%	Bacillus anthracis	Protein synthesis	Translation factors

IDP02068 (show subtarget assignments)	1	crystallized	No	YPO3194	16123356	ahpC	putative alkyl hydroperoxide reductase s...	200	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1ZOF	59%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01510 (show subtarget assignments)	1	in_crystallization_trials	No	VC0731	15640750		antioxidant, AhpC/Tsa family	207	Conserved Gene / Pathway	Phase 2: March 2008	1ZOF	55.1%	Vibrio cholerae	Cellular processes	Detoxification

IDP91255 (show subtarget assignments)	8	soluble	No	NT02SA0971	14246752	fabH	3-oxoacyl-#acyl-carrier protein synthase...	313	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ZOW	100%	Staphylococcus aureus	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00353 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2202	16804241		3-oxoacyl-(acyl carrier protein) synthas...	312	Drug Target Function	Phase 2: March 2008	1ZOW	58.1%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01192 (show subtarget assignments)	1	purified	No	BA_1184	34098435		3-oxoacyl-[acyl-carrier-protein] synthas...	310	Drug Target Function	Phase 2: March 2008	1ZOW	61%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP92111 (show subtarget assignments)	8	selected	No	TGME49_015280	237843099		iron-sulfur subunit of succinate dehydro...	342	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1ZOY	45%	Toxoplasma gondii

IDP00584 (show subtarget assignments)	1	soluble	No	YPO0117	16120462	metF	5,10-methylenetetrahydrofolate reductase...	294	Virulence Associated Factor	Phase 2: March 2008	1ZP3	86.4%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP90647 (show subtarget assignments)	8	cloned	No	VC2685	15642680	metF	5,10-methylenetetrahydrofolate reductase...	304	Predicted Essential	Community Requests	1ZP3	75.3%	Vibrio cholerae

IDP04136 (show subtarget assignments)	1	diffraction	No	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01664 (show subtarget assignments)	1	purified	No	Cj0064c	15791456	flhF	flagellar biosynthesis regulator FlhF [C...	484	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1ZU4	17.4%	Campylobacter jejuni	Cell envelope	Surface structures

IDP02625 (show subtarget assignments)	1	cloned	No	GBAA4457	47529752	aroK	shikimate kinase [Bacillus anthracis str...	165	Conserved; Drug target functions	Phase 3: June 2008	1ZUH	35.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01040 (show subtarget assignments)	1	expressed	No	STM2935	16766241	cysD	sulfate adenylyltransferase subunit 2	302	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	75.2%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP01039 (show subtarget assignments)	1	expressed	No	STM2934	16766240	cysN	sulfate adenylyltransferase subunit 1	479	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	52.4%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP91408 (show subtarget assignments)	8	soluble	No	VV1_0725	27364179	cysN	sulfate adenylyltransferase subunit 1 [V...	476	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1ZUN	54.8%	Vibrio vulnificus

IDP02232 (show subtarget assignments)	1	expressed	No	FTT1050c	56708136	cysN	sulfate adenylate transferase subunit 1 ...	470	Drug Target	Phase 3: June 2008	1ZUN	56%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo	Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP90865 (show subtarget assignments)	8	purified	No	VC2430	15642427		DNA topoisomerase IV subunit A [Vibrio c...	761	Predicted Essential	Community Requests	1ZVU	66.9%	Vibrio cholerae

IDP90866 (show subtarget assignments)	8	cloned	No	YPO0671	16120996	parC	DNA topoisomerase IV subunit A [Yersinia...	757	Predicted Essential	Community Requests	1ZVU	78.2%	Yersinia pestis

IDP90667 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1535c	15792843	pgi	glucose-6-phosphate isomerase [Campyloba...	406	Predicted Essential	Community Requests	1ZZG	30.3%	Campylobacter jejuni

IDP00130 (show subtarget assignments)	1	in_crystallization_trials	No	NT01ST5659	16767805	yjjV	putative deoxyribonuclease YjjV	257	Virulence	Phase 1: October 2007	1ZZM	76.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP92086 (show subtarget assignments)	8	selected	No	ABB03945	77819088	SOD1	iron-containing superoxide dismutase [To...	201	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2A03	59.7%	Toxoplasma gondii

IDP91701 (show subtarget assignments)	8	selected	No	NP_003053	11321571	SLIT3	slit homolog 3 protein precursor [Homo s...	1523	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2A0Z	11.2%	Homo sapiens

IDP90855 (show subtarget assignments)	8	cloned	No	VC2461	15642457	rnc	ribonuclease III [Vibrio cholerae O1 bio...	225	Predicted Essential	Community Requests	2A11	43.3%	Vibrio cholerae

IDP91699 (show subtarget assignments)	8	selected	No	NP_002750	4506103	EIF2AK2	interferon-induced, double-stranded RNA-...	551	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2A19	50.6%	Homo sapiens

IDP91745 (show subtarget assignments)	8	selected	No	Q846V4_STAAU	0			660	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2A1D	45.6%	Staphylococcus aureus

IDP00782 (show subtarget assignments)	1	cloned	No	SACOL0857	57284318		staphylocoagulase precursor, putative	508	Conserved Gene / Pathway	Phase 2: March 2008	2A1D	16.9%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP00762 (show subtarget assignments)	1	purified	No	SACOL0209	57286673		staphylocoagulase precursor	636	Conserved Gene / Pathway	Phase 2: March 2008	2A1D	29.4%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP91735 (show subtarget assignments)	8	selected	No	Q4W8J9_STAAU	0			663	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2A1D	29.9%	Staphylococcus aureus

IDP92020 (show subtarget assignments)	8	selected	No	TGME49_120640	237841247		cyclophilin, putative [Toxoplasma gondii...	764	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2A2N	15.3%	Toxoplasma gondii

IDP91969 (show subtarget assignments)	8	selected	No	SpneCM_010100009453	298255801		peptidyl-prolyl cis-trans isomerase, cyc...	267	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2A2N	31.5%	Streptococcus pneumoniae

IDP05086 (show subtarget assignments)	1	soluble	No	BA_0014	30253529		deoxynucleoside kinase family protein [B...	222	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2A2Z	29.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP92013 (show subtarget assignments)	8	selected	No	TGME49_034280	237839141		adenosine monophosphate deaminase, putat...	914	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2A3L	30.4%	Toxoplasma gondii

IDP00625 (show subtarget assignments)	1	cloned	No	SACOL2404	57285135		addiction module toxin, Txe/YoeB family ...	88	Virulence Associated Factor	Phase 2: March 2008	2A6Q	51.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP04181 (show subtarget assignments)	1	crystallized	No	VCA0197	9657589		GMP reductase [Vibrio cholerae O1 biovar...	347	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2A7R	63.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02008 (show subtarget assignments)	1	in_crystallization_trials	No	STM3595	16766881		putative phosphatase [Salmonella typhimu...	423	Conserved; Drug target functions	Phase 3: June 2008	2A96	12.8%	Salmonella enterica	Central intermediary metabolism	Other

IDP92025 (show subtarget assignments)	8	selected	No	TGME49_016130	237843251		ubiquitin-conjugating enzyme E2, putativ...	227	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2AAK	46.3%	Toxoplasma gondii

IDP05322 (show subtarget assignments)	1	cloned	No	CD3430	126701053	cbiC	cobalt-precorrin-8X methylmutase [Clostr...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AFR	41.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04726 (show subtarget assignments)	1	cloned	No	YPO1565	218928703		putative oxidoreductase [Yersinia pestis...	246	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2AG5	56.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91416 (show subtarget assignments)	8	cloned	No	VV1_0692	27364149		RNA polymerase factor sigma-54 [Vibrio v...	487	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2AHQ	7.2%	Vibrio vulnificus

IDP05562 (show subtarget assignments)	1	cloned	No	lmo2172	16804211	-	hypothetical protein lmo2172 [Listeria m...	527	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2AHU	42.1%	Listeria monocytogenes	Energy metabolism: Fermentation

IDP91770 (show subtarget assignments)	8	soluble	No	STM3096	16766397	yqgE	hypothetical protein	187	virulence/pathogenesis / This protein has been shown to be involved in the regulation of Salmonella Typhi...	Community Requests	2AJ2	48.4%	Salmonella enterica

IDP05240 (show subtarget assignments)	1	expressed	No	CD0233	126697804		hypothetical protein CD0233 [Clostridium...	130	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AJ7	33.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02576 (show subtarget assignments)	1	purified	No	GBAA0246	47525503	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	458	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2AM1	37.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00689 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2073	57284941	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	2AM1	33.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00106 (show subtarget assignments)	0	work_stopped	No	NT01SF3707	30042635	mdaB	modulator of drug activity B	193	Virulence	Phase 1: October 2007	2AMJ	97.9%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00129 (show subtarget assignments)	0	work_stopped	No	NT01ST3985	16766479	mdaB	NADPH-specific quinone oxidoreductase	193	Virulence	Phase 1: October 2007	2AMJ	91.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP90839 (show subtarget assignments)	8	purified	No	Cj0641	15792001		ATP-NAD kinase, putative [Campylobacter ...	286	Predicted Essential	Community Requests	2AN1	31.9%	Campylobacter jejuni

IDP90526 (show subtarget assignments)	8	crystallized	No	YPO1106	16121406	ppnK	inorganic polyphosphate/ATP-NAD kinase [...	293	Predicted Essential	Community Requests	2AN1	83.6%	Yersinia pestis

IDP04652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1432c	56708477	ppnK	inorganic phosphate/ATP-NAD kinase [Fran...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2AN1	41.6%	Francisella tularensis

IDP02140 (show subtarget assignments)	1	cloned	No	YPO1629	16121897		N-acetyl-D-glucosamine kinase [Yersinia ...	256	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2AP1	60.2%	Yersinia pestis	Unknown function	General

IDP90980 (show subtarget assignments)	8	cloned	No	y0801	22124714		iron-sulfur cluster insertion protein Er...	119	other biological interest / protein possibly involved in iron-sulfur cluster synthesis	Community Requests	2APN	75.6%	Yersinia pestis

IDP90752 (show subtarget assignments)	8	soluble	No	Cj1098	15792423	pyrB	aspartate carbamoyltransferase catalytic...	295	Predicted Essential	Community Requests	2AT2	38.5%	Campylobacter jejuni

IDP00670 (show subtarget assignments)	1	purified	No	SACOL1212	57285955	pyrB	aspartate carbamoyltransferase catalytic...	293	Drug Target Function	Phase 2: March 2008	2AT2	55.6%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90712 (show subtarget assignments)	8	cloned	No	Cj1638	15792943	dnaG	DNA primase [Campylobacter jejuni subsp....	605	Predicted Essential	Community Requests	2AU3	18.3%	Campylobacter jejuni

IDP90939 (show subtarget assignments)	8	expressed	No	NMPDR 243277.1.peg.3882				198	Predicted Essential	Community Requests	2AU3	34.3%	Vibrio cholerae

IDP05233 (show subtarget assignments)	1	cloned	No	lmo1455	16803495	dnaG	DNA primase [Listeria monocytogenes EGD-...	626	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2AU3	21.7%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP01708 (show subtarget assignments)	1	expressed	No	Cj0241c	15791613		putative iron-binding protein [Campyloba...	133	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2AVK	26.3%	Campylobacter jejuni	Cellular processes	Other

IDP02356 (show subtarget assignments)	1	cloned	No	FTT1296	56708355	ubiE	menaquinone biosynthesis methyltransfera...	250	Conserved; Drug target functions	Phase 3: June 2008	2AVN	20%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90893 (show subtarget assignments)	8	expressed	No	YPO3781	16123915	ubiE	ubiquinone/menaquinone biosynthesis meth...	251	Predicted Essential	Community Requests	2AVN	21.9%	Yersinia pestis

IDP01873 (show subtarget assignments)	1	cloned	No	FTT0917	56708018	maeA	malate dehydrogenase [Francisella tulare...	604	Drug Target	Phase 3: June 2008	2AW5	34.8%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP04571 (show subtarget assignments)	1	cloned	No	BAS0002	49183041		DNA polymerase III subunit beta [Bacillu...	379	Proposed to be essential proteins	Phase 4: April 2009	2AWA	42%	Bacillus anthracis

IDP02278 (show subtarget assignments)	1	expressed	No	Cj0045c	15791444		putative iron-binding protein [Campyloba...	240	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2AWC	13.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01642 (show subtarget assignments)	1	cloned	No	Cj1150c	15792474	waaE	D,D-heptose 1-phosphate adenosyltransfer...	461	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	2AWD	15.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92087 (show subtarget assignments)	8	selected	No	TGME49_116330	237831005		iron-containing superoxide dismutase [To...	287	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2AWP	41.1%	Toxoplasma gondii

IDP02117 (show subtarget assignments)	1	in_crystallization_trials	No	STM4356	16767602	yjeF	hypothetical protein STM4356 [Salmonella...	515	Conserved; Drug target functions	Phase 3: June 2008	2AX3	31.3%	Salmonella enterica	Unknown function	General

IDP01679 (show subtarget assignments)	1	cloned	No	FTT0738	56707853	yjeF	carbohydrate kinase family protein (YjeF...	514	Conserved; Drug target functions	Phase 3: June 2008	2AX3	28%	Francisella tularensis	Energy metabolism	Sugars

IDP91704 (show subtarget assignments)	8	selected	No	NP_004528	4758756	NAP1L1	nucleosome assembly protein 1-like 1 [Ho...	391	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2AYU	35%	Homo sapiens

IDP02120 (show subtarget assignments)	1	expressed	No	YPO0027	16120380		phosphatase [Yersinia pestis CO92]	196	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2B0C	66.8%	Yersinia pestis	Unknown function	General

IDP92112 (show subtarget assignments)	8	selected	No	TGME49_057730	237831419		methionine aminopeptidase, putative [Tox...	387	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2B3H	32.3%	Toxoplasma gondii

IDP02652 (show subtarget assignments)	1	expressed	No	GBAA1422	47526694	leuC	isopropylmalate isomerase large subunit ...	464	Conserved; Drug target functions	Phase 3: June 2008	2B3X	22%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP01692 (show subtarget assignments)	1	cloned	No	FTT1671	56708681	ribD	riboflavin biosynthesis protein ribD [Fr...	355	Conserved; Drug target functions	Phase 3: June 2008	2B3Z	37.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05270 (show subtarget assignments)	1	soluble	No	lmo1016	16803056	gbuC	hypothetical protein lmo1016 [Listeria m...	249	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2B4L	51%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP91755 (show subtarget assignments)	8	selected	No	TXD11_HUMAN	0			958	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2B5E	7%	Homo sapiens

IDP02780 (show subtarget assignments)	1	soluble	No	GBAA0507	47525777		NAD-dependent epimerase/dehydratase fami...	321	Conserved; Drug target functions	Phase 3: June 2008	2B69	35.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91801 (show subtarget assignments)	8	purified	No	AAQ16565	33356632		DAHP synthetase [Toxoplasma gondii]	615	potential drug target / The presence of the shikimate pathway in a large number of pathogenic organisms,...	Community Requests	2B7O	28.6%	Toxoplasma gondii

IDP01645 (show subtarget assignments)	1	soluble	No	lmo2509	16804547	prfB	peptide chain release factor 2 [Listeria...	327	Predicted virulence-Regulation; Possible Vaccine Candidate	Phase 3: June 2008	2B9M	49.2%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP01770 (show subtarget assignments)	1	expressed	No	Cj1447c	15792764	kpsT	capsular polysaccharide ABC transporter,...	220	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2BBS	26.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92012 (show subtarget assignments)	8	selected	No	TGME49_037830	237845437		DNA polymerase I, putative [Toxoplasma g...	938	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BDP	17.4%	Toxoplasma gondii

IDP04109 (show subtarget assignments)	1	crystallized	No	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP91385 (show subtarget assignments)	8	soluble	No	VV1_1465	27364849	pyrB	aspartate carbamoyltransferase catalytic...	309	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2BE7	76.4%	Vibrio vulnificus

IDP90501 (show subtarget assignments)	8	purified	No	Q9KP66	22257009		RecName: Full=Aspartate carbamoyltransfe...	309	Predicted Essential	Community Requests	2BE7	77.7%	Vibrio cholerae

IDP05700 (show subtarget assignments)	1	soluble	No	lmo2467	16804505	-	hypothetical protein lmo2467 [Listeria m...	478	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2BEM	18.2%	Listeria monocytogenes	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP92016 (show subtarget assignments)	8	selected	No	TGME49_078830	237842577		glucose-6-phosphate dehydrogenase, putat...	878	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BH9	27.8%	Toxoplasma gondii

IDP04480 (show subtarget assignments)	1	selected	No	YPO3104	218930142	wbyK	putative mannosyltransferase [Yersinia p...	337	drug target; virulence factor; putative drug target function;	Phase 4: April 2009	2BIS	25.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90929 (show subtarget assignments)	8	cloned	No	STM3714	16766999	rfaK	putative hexose transferase [Salmonella ...	381	Predicted Essential	Community Requests	2BIS	21.5%	Salmonella enterica

IDP91212 (show subtarget assignments)	8	cloned	No	BLIJ_1793	189439586	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	445	potential drug target / Shikimate pathway enzyme	Community Requests	2BJB	44.9%	Bifidobacterium longum

IDP02459 (show subtarget assignments)	1	soluble	No	lmo2067	16804106		hypothetical protein lmo2067 [Listeria m...	325	Known virulence-Bile resistance; PMID:15664931	Phase 3: June 2008	2BJF	38.8%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP90173 (show subtarget assignments)	8	cloned	No	AAM13464.1	20153003	CPXV017 CDS	CPXV017 protein	435	ankyrin repeat protein	Community Requests	2BKG	9.9%	Cowpox virus	conserved hypothetical proteins	0

IDP91870 (show subtarget assignments)	8	selected	No	CAA30578	38663		unnamed protein product [Acinetobacter b...	259	drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation	Community Requests	2BKK	34.4%	Acinetobacter baumannii

IDP91711 (show subtarget assignments)	8	selected	No	NP_006550	5730027	KHDRBS1	KH domain-containing, RNA-binding, signa...	443	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2BL5	14.7%	Homo sapiens

IDP92108 (show subtarget assignments)	8	selected	No	TGME49_093180	237841645		NADP-specific glutamate dehydrogenase, p...	489	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BMA	52.4%	Toxoplasma gondii

IDP04085 (show subtarget assignments)	1	expressed	No	VC0525	15640547		2-amino-4-hydroxy-6-hydroxymethyldihydro...	195	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2BMB	30.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00561 (show subtarget assignments)	0	work_stopped	No	YPO1046	16121346	pyrH	uridylate kinase	241	Conserved Gene / Pathway	Phase 2: March 2008	2BNE	90.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00068 (show subtarget assignments)	0	work_stopped	No	NT01ST0271	16418722	pyrH	uridylate kinase	241	Essential	Phase 1: October 2007	2BNE	97.9%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP92085 (show subtarget assignments)	8	selected	No	TGME49_116190	237830977		superoxide dismutase, putative [Toxoplas...	258	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BPI	41.9%	Toxoplasma gondii

IDP02034 (show subtarget assignments)	1	cloned	No	lmo0059	16802107		hypothetical protein lmo0059 [Listeria m...	83	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008	2BPS	27.7%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP04228 (show subtarget assignments)	1	cloned	No	CPF_0675	110800755	purM	phosphoribosylaminoimidazole synthetase ...	333	conserved gene; putative drug target function;	Phase 4: April 2009	2BTU	54.9%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02670 (show subtarget assignments)	1	cloned	No	GBAA4353	47529649	argB	acetylglutamate kinase [Bacillus anthrac...	255	Conserved; Drug target functions	Phase 3: June 2008	2BTY	43.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02765 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2632	47527924		cytochrome P450 family protein [Bacillus...	404	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2BVJ	34.9%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02720
(show subtarget assignments)

1

cloned

No

GBAA3950

47529240

infB

translation initiation factor IF-2 [Baci...

686

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1ZO1

42%

Bacillus anthracis

Protein synthesis

Translation factors

IDP02068
(show subtarget assignments)

1

crystallized

No

YPO3194

16123356

ahpC

putative alkyl hydroperoxide reductase s...

200

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1ZOF

59%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01510
(show subtarget assignments)

1

in_crystallization_trials

No

VC0731

15640750

antioxidant, AhpC/Tsa family

207

Conserved Gene / Pathway

Phase 2: March 2008

1ZOF

55.1%

Vibrio cholerae

Cellular processes

Detoxification

IDP91255
(show subtarget assignments)

8

soluble

No

NT02SA0971

14246752

fabH

3-oxoacyl-#acyl-carrier protein synthase...

313

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ZOW

100%

Staphylococcus aureus

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00353
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2202

16804241

3-oxoacyl-(acyl carrier protein) synthas...

312

Drug Target Function

Phase 2: March 2008

1ZOW

58.1%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01192
(show subtarget assignments)

1

purified

No

BA_1184

34098435

3-oxoacyl-[acyl-carrier-protein] synthas...

310

Drug Target Function

Phase 2: March 2008

1ZOW

61%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP92111
(show subtarget assignments)

8

selected

No

TGME49_015280

237843099

iron-sulfur subunit of succinate dehydro...

342

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1ZOY

45%

Toxoplasma gondii

IDP00584
(show subtarget assignments)

1

soluble

No

YPO0117

16120462

metF

5,10-methylenetetrahydrofolate reductase...

294

Virulence Associated Factor

Phase 2: March 2008

1ZP3

86.4%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP90647
(show subtarget assignments)

8

cloned

No

VC2685

15642680

metF

5,10-methylenetetrahydrofolate reductase...

304

Predicted Essential

Community Requests

1ZP3

75.3%

Vibrio cholerae

IDP04136
(show subtarget assignments)

1

diffraction

No

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01664
(show subtarget assignments)

1

purified

No

Cj0064c

15791456

flhF

flagellar biosynthesis regulator FlhF [C...

484

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1ZU4

17.4%

Campylobacter jejuni

Cell envelope

Surface structures

IDP02625
(show subtarget assignments)

1

cloned

No

GBAA4457

47529752

aroK

shikimate kinase [Bacillus anthracis str...

165

Conserved; Drug target functions

Phase 3: June 2008

1ZUH

35.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01040
(show subtarget assignments)

1

expressed

No

STM2935

16766241

cysD

sulfate adenylyltransferase subunit 2

302

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

75.2%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP01039
(show subtarget assignments)

1

expressed

No

STM2934

16766240

cysN

sulfate adenylyltransferase subunit 1

479

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

52.4%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP91408
(show subtarget assignments)

8

soluble

No

VV1_0725

27364179

cysN

sulfate adenylyltransferase subunit 1 [V...

476

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1ZUN

54.8%

Vibrio vulnificus

IDP02232
(show subtarget assignments)

1

expressed

No

FTT1050c

56708136

cysN

sulfate adenylate transferase subunit 1 ...

470

Drug Target

Phase 3: June 2008

1ZUN

56%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo

Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP90865
(show subtarget assignments)

8

purified

No

VC2430

15642427

DNA topoisomerase IV subunit A [Vibrio c...

761

Predicted Essential

Community Requests

1ZVU

66.9%

Vibrio cholerae

IDP90866
(show subtarget assignments)

8

cloned

No

YPO0671

16120996

parC

DNA topoisomerase IV subunit A [Yersinia...

757

Predicted Essential

Community Requests

1ZVU

78.2%

Yersinia pestis

IDP90667
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1535c

15792843

pgi

glucose-6-phosphate isomerase [Campyloba...

406

Predicted Essential

Community Requests

1ZZG

30.3%

Campylobacter jejuni

IDP00130
(show subtarget assignments)

1

in_crystallization_trials

No

NT01ST5659

16767805

yjjV

putative deoxyribonuclease YjjV

257

Virulence

Phase 1: October 2007

1ZZM

76.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP92086
(show subtarget assignments)

8

selected

No

ABB03945

77819088

SOD1

iron-containing superoxide dismutase [To...

201

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2A03

59.7%

Toxoplasma gondii

IDP91701
(show subtarget assignments)

8

selected

No

NP_003053

11321571

SLIT3

slit homolog 3 protein precursor [Homo s...

1523

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2A0Z

11.2%

Homo sapiens

IDP90855
(show subtarget assignments)

8

cloned

No

VC2461

15642457

rnc

ribonuclease III [Vibrio cholerae O1 bio...

225

Predicted Essential

Community Requests

2A11

43.3%

Vibrio cholerae

IDP91699
(show subtarget assignments)

8

selected

No

NP_002750

4506103

EIF2AK2

interferon-induced, double-stranded RNA-...

551

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2A19

50.6%

Homo sapiens

IDP91745
(show subtarget assignments)

8

selected

No

Q846V4_STAAU

0

660

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2A1D

45.6%

Staphylococcus aureus

IDP00782
(show subtarget assignments)

1

cloned

No

SACOL0857

57284318

staphylocoagulase precursor, putative

508

Conserved Gene / Pathway

Phase 2: March 2008

2A1D

16.9%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP00762
(show subtarget assignments)

1

purified

No

SACOL0209

57286673

staphylocoagulase precursor

636

Conserved Gene / Pathway

Phase 2: March 2008

2A1D

29.4%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP91735
(show subtarget assignments)

8

selected

No

Q4W8J9_STAAU

0

663

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2A1D

29.9%

Staphylococcus aureus

IDP92020
(show subtarget assignments)

8

selected

No

TGME49_120640

237841247

cyclophilin, putative [Toxoplasma gondii...

764

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2A2N

15.3%

Toxoplasma gondii

IDP91969
(show subtarget assignments)

8

selected

No

SpneCM_010100009453

298255801

peptidyl-prolyl cis-trans isomerase, cyc...

267

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2A2N

31.5%

Streptococcus pneumoniae

IDP05086
(show subtarget assignments)

1

soluble

No

BA_0014

30253529

deoxynucleoside kinase family protein [B...

222

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2A2Z

29.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP92013
(show subtarget assignments)

8

selected

No

TGME49_034280

237839141

adenosine monophosphate deaminase, putat...

914

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2A3L

30.4%

Toxoplasma gondii

IDP00625
(show subtarget assignments)

1

cloned

No

SACOL2404

57285135

addiction module toxin, Txe/YoeB family ...

88

Virulence Associated Factor

Phase 2: March 2008

2A6Q

51.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP04181
(show subtarget assignments)

1

crystallized

No

VCA0197

9657589

GMP reductase [Vibrio cholerae O1 biovar...

347

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2A7R

63.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02008
(show subtarget assignments)

1

in_crystallization_trials

No

STM3595

16766881

putative phosphatase [Salmonella typhimu...

423

Conserved; Drug target functions

Phase 3: June 2008

2A96

12.8%

Salmonella enterica

Central intermediary metabolism

Other

IDP92025
(show subtarget assignments)

8

selected

No

TGME49_016130

237843251

ubiquitin-conjugating enzyme E2, putativ...

227

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2AAK

46.3%

Toxoplasma gondii

IDP05322
(show subtarget assignments)

1

cloned

No

CD3430

126701053

cbiC

cobalt-precorrin-8X methylmutase [Clostr...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AFR

41.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04726
(show subtarget assignments)

1

cloned

No

YPO1565

218928703

putative oxidoreductase [Yersinia pestis...

246

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2AG5

56.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91416
(show subtarget assignments)

8

cloned

No

VV1_0692

27364149

RNA polymerase factor sigma-54 [Vibrio v...

487

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2AHQ

7.2%

Vibrio vulnificus

IDP05562
(show subtarget assignments)

1

cloned

No

lmo2172

16804211

-

hypothetical protein lmo2172 [Listeria m...

527

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2AHU

42.1%

Listeria monocytogenes

Energy metabolism: Fermentation

IDP91770
(show subtarget assignments)

8

soluble

No

STM3096

16766397

yqgE

hypothetical protein

187

virulence/pathogenesis / This protein has been shown to be involved in the regulation of Salmonella Typhi...

Community Requests

2AJ2

48.4%

Salmonella enterica

IDP05240
(show subtarget assignments)

1

expressed

No

CD0233

126697804

hypothetical protein CD0233 [Clostridium...

130

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AJ7

33.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02576
(show subtarget assignments)

1

purified

No

GBAA0246

47525503

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

458

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2AM1

37.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00689
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2073

57284941

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

2AM1

33.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00106
(show subtarget assignments)

0

work_stopped

No

NT01SF3707

30042635

mdaB

modulator of drug activity B

193

Virulence

Phase 1: October 2007

2AMJ

97.9%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00129
(show subtarget assignments)

0

work_stopped

No

NT01ST3985

16766479

mdaB

NADPH-specific quinone oxidoreductase

193

Virulence

Phase 1: October 2007

2AMJ

91.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP90839
(show subtarget assignments)

8

purified

No

Cj0641

15792001

ATP-NAD kinase, putative [Campylobacter ...

286

Predicted Essential

Community Requests

2AN1

31.9%

Campylobacter jejuni

IDP90526
(show subtarget assignments)

8

crystallized

No

YPO1106

16121406

ppnK

inorganic polyphosphate/ATP-NAD kinase [...

293

Predicted Essential

Community Requests

2AN1

83.6%

Yersinia pestis

IDP04652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1432c

56708477

ppnK

inorganic phosphate/ATP-NAD kinase [Fran...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2AN1

41.6%

Francisella tularensis

IDP02140
(show subtarget assignments)

1

cloned

No

YPO1629

16121897

N-acetyl-D-glucosamine kinase [Yersinia ...

256

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2AP1

60.2%

Yersinia pestis

Unknown function

General

IDP90980
(show subtarget assignments)

8

cloned

No

y0801

22124714

iron-sulfur cluster insertion protein Er...

119

other biological interest / protein possibly involved in iron-sulfur cluster synthesis

Community Requests

2APN

75.6%

Yersinia pestis

IDP90752
(show subtarget assignments)

8

soluble

No

Cj1098

15792423

pyrB

aspartate carbamoyltransferase catalytic...

295

Predicted Essential

Community Requests

2AT2

38.5%

Campylobacter jejuni

IDP00670
(show subtarget assignments)

1

purified

No

SACOL1212

57285955

pyrB

aspartate carbamoyltransferase catalytic...

293

Drug Target Function

Phase 2: March 2008

2AT2

55.6%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90712
(show subtarget assignments)

8

cloned

No

Cj1638

15792943

dnaG

DNA primase [Campylobacter jejuni subsp....

605

Predicted Essential

Community Requests

2AU3

18.3%

Campylobacter jejuni

IDP90939
(show subtarget assignments)

8

expressed

No

NMPDR 243277.1.peg.3882

198

Predicted Essential

Community Requests

2AU3

34.3%

Vibrio cholerae

IDP05233
(show subtarget assignments)

1

cloned

No

lmo1455

16803495

dnaG

DNA primase [Listeria monocytogenes EGD-...

626

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2AU3

21.7%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP01708
(show subtarget assignments)

1

expressed

No

Cj0241c

15791613

putative iron-binding protein [Campyloba...

133

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2AVK

26.3%

Campylobacter jejuni

Cellular processes

Other

IDP02356
(show subtarget assignments)

1

cloned

No

FTT1296

56708355

ubiE

menaquinone biosynthesis methyltransfera...

250

Conserved; Drug target functions

Phase 3: June 2008

2AVN

20%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90893
(show subtarget assignments)

8

expressed

No

YPO3781

16123915

ubiE

ubiquinone/menaquinone biosynthesis meth...

251

Predicted Essential

Community Requests

2AVN

21.9%

Yersinia pestis

IDP01873
(show subtarget assignments)

1

cloned

No

FTT0917

56708018

maeA

malate dehydrogenase [Francisella tulare...

604

Drug Target

Phase 3: June 2008

2AW5

34.8%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP04571
(show subtarget assignments)

1

cloned

No

BAS0002

49183041

DNA polymerase III subunit beta [Bacillu...

379

Proposed to be essential proteins

Phase 4: April 2009

2AWA

42%

Bacillus anthracis

IDP02278
(show subtarget assignments)

1

expressed

No

Cj0045c

15791444

putative iron-binding protein [Campyloba...

240

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2AWC

13.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01642
(show subtarget assignments)

1

cloned

No

Cj1150c

15792474

waaE

D,D-heptose 1-phosphate adenosyltransfer...

461

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

2AWD

15.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92087
(show subtarget assignments)

8

selected

No

TGME49_116330

237831005

iron-containing superoxide dismutase [To...

287

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2AWP

41.1%

Toxoplasma gondii

IDP02117
(show subtarget assignments)

1

in_crystallization_trials

No

STM4356

16767602

yjeF

hypothetical protein STM4356 [Salmonella...

515

Conserved; Drug target functions

Phase 3: June 2008

2AX3

31.3%

Salmonella enterica

Unknown function

General

IDP01679
(show subtarget assignments)

1

cloned

No

FTT0738

56707853

yjeF

carbohydrate kinase family protein (YjeF...

514

Conserved; Drug target functions

Phase 3: June 2008

2AX3

28%

Francisella tularensis

Energy metabolism

Sugars

IDP91704
(show subtarget assignments)

8

selected

No

NP_004528

4758756

NAP1L1

nucleosome assembly protein 1-like 1 [Ho...

391

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2AYU

35%

Homo sapiens

IDP02120
(show subtarget assignments)

1

expressed

No

YPO0027

16120380

phosphatase [Yersinia pestis CO92]

196

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2B0C

66.8%

Yersinia pestis

Unknown function

General

IDP92112
(show subtarget assignments)

8

selected

No

TGME49_057730

237831419

methionine aminopeptidase, putative [Tox...

387

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2B3H

32.3%

Toxoplasma gondii

IDP02652
(show subtarget assignments)

1

expressed

No

GBAA1422

47526694

leuC

isopropylmalate isomerase large subunit ...

464

Conserved; Drug target functions

Phase 3: June 2008

2B3X

22%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP01692
(show subtarget assignments)

1

cloned

No

FTT1671

56708681

ribD

riboflavin biosynthesis protein ribD [Fr...

355

Conserved; Drug target functions

Phase 3: June 2008

2B3Z

37.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05270
(show subtarget assignments)

1

soluble

No

lmo1016

16803056

gbuC

hypothetical protein lmo1016 [Listeria m...

249

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2B4L

51%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP91755
(show subtarget assignments)

8

selected

No

TXD11_HUMAN

0

958

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2B5E

7%

Homo sapiens

IDP02780
(show subtarget assignments)

1

soluble

No

GBAA0507

47525777

NAD-dependent epimerase/dehydratase fami...

321

Conserved; Drug target functions

Phase 3: June 2008

2B69

35.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91801
(show subtarget assignments)

8

purified

No

AAQ16565

33356632

DAHP synthetase [Toxoplasma gondii]

615

potential drug target / The presence of the shikimate pathway in a large number of pathogenic organisms,...

Community Requests

2B7O

28.6%

Toxoplasma gondii

IDP01645
(show subtarget assignments)

1

soluble

No

lmo2509

16804547

prfB

peptide chain release factor 2 [Listeria...

327

Predicted virulence-Regulation; Possible Vaccine Candidate

Phase 3: June 2008

2B9M

49.2%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP01770
(show subtarget assignments)

1

expressed

No

Cj1447c

15792764

kpsT

capsular polysaccharide ABC transporter,...

220

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2BBS

26.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92012
(show subtarget assignments)

8

selected

No

TGME49_037830

237845437

DNA polymerase I, putative [Toxoplasma g...

938

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BDP

17.4%

Toxoplasma gondii

IDP04109
(show subtarget assignments)

1

crystallized

No

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP91385
(show subtarget assignments)

8

soluble

No

VV1_1465

27364849

pyrB

aspartate carbamoyltransferase catalytic...

309

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2BE7

76.4%

Vibrio vulnificus

IDP90501
(show subtarget assignments)

8

purified

No

Q9KP66

22257009

RecName: Full=Aspartate carbamoyltransfe...

309

Predicted Essential

Community Requests

2BE7

77.7%

Vibrio cholerae

IDP05700
(show subtarget assignments)

1

soluble

No

lmo2467

16804505

-

hypothetical protein lmo2467 [Listeria m...

478

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2BEM

18.2%

Listeria monocytogenes

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP92016
(show subtarget assignments)

8

selected

No

TGME49_078830

237842577

glucose-6-phosphate dehydrogenase, putat...

878

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BH9

27.8%

Toxoplasma gondii

IDP04480
(show subtarget assignments)

1

selected

No

YPO3104

218930142

wbyK

putative mannosyltransferase [Yersinia p...

337

drug target; virulence factor; putative drug target function;

Phase 4: April 2009

2BIS

25.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90929
(show subtarget assignments)

8

cloned

No

STM3714

16766999

rfaK

putative hexose transferase [Salmonella ...

381

Predicted Essential

Community Requests

2BIS

21.5%

Salmonella enterica

IDP91212
(show subtarget assignments)

8

cloned

No

BLIJ_1793

189439586

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

445

potential drug target / Shikimate pathway enzyme

Community Requests

2BJB

44.9%

Bifidobacterium longum

IDP02459
(show subtarget assignments)

1

soluble

No

lmo2067

16804106

hypothetical protein lmo2067 [Listeria m...

325

Known virulence-Bile resistance; PMID:15664931

Phase 3: June 2008

2BJF

38.8%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP90173
(show subtarget assignments)

8

cloned

No

AAM13464.1

20153003

CPXV017 CDS

CPXV017 protein

435

ankyrin repeat protein

Community Requests

2BKG

9.9%

Cowpox virus

conserved hypothetical proteins

0

IDP91870
(show subtarget assignments)

8

selected

No

CAA30578

38663

unnamed protein product [Acinetobacter b...

259

drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation

Community Requests

2BKK

34.4%

Acinetobacter baumannii

IDP91711
(show subtarget assignments)

8

selected

No

NP_006550

5730027

KHDRBS1

KH domain-containing, RNA-binding, signa...

443

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2BL5

14.7%

Homo sapiens

IDP92108
(show subtarget assignments)

8

selected

No

TGME49_093180

237841645

NADP-specific glutamate dehydrogenase, p...

489

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BMA

52.4%

Toxoplasma gondii

IDP04085
(show subtarget assignments)

1

expressed

No

VC0525

15640547

2-amino-4-hydroxy-6-hydroxymethyldihydro...

195

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2BMB

30.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00561
(show subtarget assignments)

0

work_stopped

No

YPO1046

16121346

pyrH

uridylate kinase

241

Conserved Gene / Pathway

Phase 2: March 2008

2BNE

90.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00068
(show subtarget assignments)

0

work_stopped

No

NT01ST0271

16418722

pyrH

uridylate kinase

241

Essential

Phase 1: October 2007

2BNE

97.9%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP92085
(show subtarget assignments)

8

selected

No

TGME49_116190

237830977

superoxide dismutase, putative [Toxoplas...

258

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BPI

41.9%

Toxoplasma gondii

IDP02034
(show subtarget assignments)

1

cloned

No

lmo0059

16802107

hypothetical protein lmo0059 [Listeria m...

83

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

2BPS

27.7%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP04228
(show subtarget assignments)

1

cloned

No

CPF_0675

110800755

purM

phosphoribosylaminoimidazole synthetase ...

333

conserved gene; putative drug target function;

Phase 4: April 2009

2BTU

54.9%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02670
(show subtarget assignments)

1

cloned

No

GBAA4353

47529649

argB

acetylglutamate kinase [Bacillus anthrac...

255

Conserved; Drug target functions

Phase 3: June 2008

2BTY

43.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02765
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2632

47527924

cytochrome P450 family protein [Bacillus...

404

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2BVJ

34.9%

Bacillus anthracis

Central intermediary metabolism

Other