Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04082 (show subtarget assignments)	1	cloned	No	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04414 (show subtarget assignments)	8	selected	No	CAC05786	12329055	sepA	SepA, extracellular serine protease of t...	1364	Shigella effector protein	Community Requests	1WXR	34.9%	Shigella flexneri

IDP02765 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2632	47527924		cytochrome P450 family protein [Bacillus...	404	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2BVJ	34.9%	Bacillus anthracis	Central intermediary metabolism	Other

IDP91254 (show subtarget assignments)	8	soluble	No	NT02SA0910	14246689		probable 2-nitropropane dioxygenase [Sta...	355	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3BW2	34.9%	Staphylococcus aureus	Cellular processes: Detoxification

IDP01258 (show subtarget assignments)	1	soluble	No	BA_2238	30256883	pbpC	penicillin-binding protein 3	661	Drug Target Function	Phase 2: March 2008	1MWR	34.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01229 (show subtarget assignments)	1	soluble	No	BA_4540	52782922		Protein grpE (HSP-70 cofactor)	188	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	34.9%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP90794 (show subtarget assignments)	8	purified	No	Cj0763c	15792101	cysE	serine acetyltransferase [Campylobacter ...	212	Predicted Essential	Community Requests	3P1B	34.9%	Campylobacter jejuni

IDP05299 (show subtarget assignments)	1	soluble	No	CD2524	126700141	nadD	nicotinate-nucleotide adenylyltransferas...	229	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KAM	34.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP90694 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0840c	15792178	fbp	fructose-1,6-bisphosphatase [Campylobact...	280	Predicted Essential	Community Requests	3IFA	34.9%	Campylobacter jejuni

IDP91621 (show subtarget assignments)	8	soluble	No	BAB35649	13361692	ECs2226	hypothetical protein [Escherichia coli O...	123	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	35%	Escherichia coli

IDP01968 (show subtarget assignments)	1	purified	No	STM1954	16765292	fliY	cystine transporter subunit [Salmonella ...	266	Conserved; Drug target functions	Phase 3: June 2008	2YLN	35%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP05558 (show subtarget assignments)	1	soluble	No	lmo1757	16803797	-	hypothetical protein lmo1757 [Listeria m...	371	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IB5	35%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP05681 (show subtarget assignments)	1	cloned	No	lmo1277	16803317	codV	hypothetical protein lmo1277 [Listeria m...	300	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1A0P	35%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Prophage functions

IDP01426 (show subtarget assignments)	1	expressed	No	VC1680	15641684		peptide ABC transporter, periplasmic pep...	540	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	35%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91637 (show subtarget assignments)	8	cloned	No	NP_215056	15607682		O-succinylbenzoic acid--CoA ligase [Myco...	362	drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...	Community Requests	3NYQ	35%	Mycobacterium tuberculosis

IDP91704 (show subtarget assignments)	8	selected	No	NP_004528	4758756	NAP1L1	nucleosome assembly protein 1-like 1 [Ho...	391	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2AYU	35%	Homo sapiens

IDP00608 (show subtarget assignments)	1	expressed	No	SACOL0127	57285334		phosphonate ABC transporter, ATP-binding...	257	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35%	Staphylococcus aureus	Transport and binding proteins	Other

IDP02747 (show subtarget assignments)	1	soluble	No	FTT0147	56707317	gcp	O-sialoglycoprotein endopeptidase [Franc...	336	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2IVN	35.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00985 (show subtarget assignments)	1	soluble	No	STM2076	16765406	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	245	Conserved Gene / Pathway	Phase 2: March 2008	2Y85	35.1%	Salmonella enterica	Amino acid biosynthesis	Histidine family

IDP01948 (show subtarget assignments)	1	in_crystallization_trials	No	STM1931	16765272	araH	putative intracellular protease/amidase ...	185	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	4E08	35.1%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00213 (show subtarget assignments)	1	soluble	No	YPO0628	16120954	-	putative translational inhibitor protein...	134	Virulence	Phase 1: October 2007	3I7T	35.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04169 (show subtarget assignments)	1	in_crystallization_trials	No	VC2180	15642179	hemA	glutamyl-tRNA reductase [Vibrio cholerae...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPJ	35.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01703 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1317	15792640	neuB3	N-acetylneuraminic acid synthetase [Camp...	343	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	1XUU	35.1%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP91777 (show subtarget assignments)	8	purified	No	AAC33914	3513664	sul1	Sul1 dihydropteroate synthase [Escherich...	279	drug resistance / Dihydropteroate synthase (sulfonamide resistance)	Community Requests	1EYE	35.1%	Escherichia coli

IDP04517 (show subtarget assignments)	1	cloned	No	CPF_2840	110799025	ksgA	dimethyladenosine transferase [Clostridi...	285	conserved gene; putative drug target function;	Phase 4: April 2009	3FUT	35.1%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP92081 (show subtarget assignments)	8	selected	No	TGME49_106970	237845145		thymidylate kinase, putative [Toxoplasma...	273	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1E2D	35.2%	Toxoplasma gondii

IDP00508 (show subtarget assignments)	1	expressed	No	YPO1315	16121597		putative hydrolase	216	Conserved Gene / Pathway	Phase 2: March 2008	3FVV	35.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP90531 (show subtarget assignments)	8	cloned	No	Q9KSF9	20139940		RecName: Full=Asparaginyl-tRNA synthetas...	466	Predicted Essential	Community Requests	1X54	35.2%	Vibrio cholerae

IDP02625 (show subtarget assignments)	1	cloned	No	GBAA4457	47529752	aroK	shikimate kinase [Bacillus anthracis str...	165	Conserved; Drug target functions	Phase 3: June 2008	1ZUH	35.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP05490 (show subtarget assignments)	1	soluble	No	BA_5139	30259623	sodC	superoxide dismutase, Cu-Zn [Bacillus an...	179	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XTM	35.2%	Bacillus anthracis	Cellular processes: Detoxification

IDP01702 (show subtarget assignments)	1	soluble	No	GBAA0261	47525520	gcP	O-sialoglycoprotein endopeptidase [Bacil...	338	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IVN	35.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01613 (show subtarget assignments)	1	in_crystallization_trials	No	STM1927	16765269	yecG	universal stress protein UspC [Salmonell...	142	Conserved; Drug target functions	Phase 3: June 2008	1JMV	35.2%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP02780 (show subtarget assignments)	1	soluble	No	GBAA0507	47525777		NAD-dependent epimerase/dehydratase fami...	321	Conserved; Drug target functions	Phase 3: June 2008	2B69	35.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05534 (show subtarget assignments)	1	in_crystallization_trials	No	CD3106	126700723		putative phopho-sugar aldolase [Clostrid...	213	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3R8R	35.2%	Clostridium difficile	Unknown function: General

IDP00525 (show subtarget assignments)	1	cloned	No	YPMT1.83	16082875	caf1A	putative F1 capsule anchoring protein	833	Virulence Associated Factor	Phase 2: March 2008	3RFZ	35.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02004 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0994c	56708086		MRP like protein [Francisella tularensis...	286	Conserved; Drug target functions	Phase 3: June 2008	2PH1	35.3%	Francisella tularensis	Cellular processes	Cell division

IDP02557 (show subtarget assignments)	1	purified	No	Cj0061c	15791453	fliA	flagellar biosynthesis sigma factor [Cam...	238	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1RP3	35.3%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP00981 (show subtarget assignments)	1	in_crystallization_trials	No	STM2052	16765382	pduQ	propanol dehydrogenase	370	Conserved Gene / Pathway	Phase 2: March 2008	3OWO	35.3%	Salmonella enterica	Energy metabolism	Fermentation

IDP92132 (show subtarget assignments)	8	selected	No	TGME49_053290	237840177		valyl-tRNA synthetase, putative [Toxopla...	1042	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1GAX	35.3%	Toxoplasma gondii

IDP01814 (show subtarget assignments)	1	expressed	No	STM1753	16765097	hnr	response regulator of RpoS [Salmonella t...	337	Conserved; Drug target functions	Phase 3: June 2008	3EOD	35.3%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02284 (show subtarget assignments)	1	soluble	No	CBU_1293	29541861	grpE	heat shock protein GrpE [Coxiella burnet...	204	Conserved; Drug target functions	Phase 3: June 2008	1DKG	35.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP05574 (show subtarget assignments)	1	soluble	No	SACOL0533	57651372	metS	methionyl-tRNA synthetase [Staphylococcu...	657	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2CSX	35.3%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP00433 (show subtarget assignments)	1	purified	No	YPO1545	16121818	hisH	imidazole glycerol phosphate synthase su...	196	Drug Target Function	Phase 2: March 2008	1GPW	35.3%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP01615 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0643	29541244	ribD	riboflavin biosynthesis protein RibD [Co...	354	Conserved; Drug target functions	Phase 3: June 2008	2HXV	35.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04211 (show subtarget assignments)	1	expressed	No	STM0408_1_323	16763788	secF	preprotein translocase subunit SecF [Sal...	323	Salmonella essential protein	Phase 4: April 2009	3AQP	35.3%	Salmonella enterica

IDP00345 (show subtarget assignments)	1	cloned	No	lmo0441	16802485		hypothetical protein lmo0441	678	Drug Target Function	Phase 2: March 2008	1MWR	35.3%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05644 (show subtarget assignments)	1	cloned	No	CD3230	126700850	bclA2	exosporium glycoprotein [Clostridium dif...	558	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	35.3%	Clostridium difficile	Unclassified: Role category not yet assigned

IDP00062 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4511	50400989		4-hydroxy-3-methylbut-2-enyl diphosphate...	316	Virulence	Phase 1: October 2007	3F7T	35.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02079 (show subtarget assignments)	1	expressed	No	Cj0173c	15791560		iron ABC transporter, ATP binding subuni...	302	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2D62	35.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01797 (show subtarget assignments)	1	cloned	No	CBU_1008	29541590	bioA	adenosylmethionine-8-amino-7-oxononanoat...	442	Conserved; Drug target functions	Phase 3: June 2008	3DOD	35.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01763 (show subtarget assignments)	1	cloned	No	YPO3627	16123769	ssuB	aliphatic sulfonates transport ATP-bindi...	271	Conserved; CD; Drug target functions	Phase 3: June 2008	2IT1	35.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP05320 (show subtarget assignments)	1	cloned	No	lmo0177	16802223	metS	methionyl-tRNA synthetase [Listeria mono...	630	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2CSX	35.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP91971 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100002131	298254398		lipoprotein [Streptococcus pneumoniae st...	350	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2FQW	35.4%	Streptococcus pneumoniae

IDP91172 (show subtarget assignments)	8	purified	No	PA1706	15596903	pcrV	type III secretion protein PcrV [Pseudom...	294	potential drug target / P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...	Community Requests	1R6F	35.4%	Pseudomonas aeruginosa

IDP90716 (show subtarget assignments)	8	soluble	No	Cj0576	15791936	lpxD	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	321	Predicted Essential	Community Requests	2IU8	35.5%	Campylobacter jejuni

IDP91950 (show subtarget assignments)	8	selected	No	SpneCM_010100006639	298255269		beta-N-acetylhexosaminidase [Streptococc...	1312	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3RPM	35.5%	Streptococcus pneumoniae

IDP90534 (show subtarget assignments)	8	cloned	No	Cj1071	15792396	ssb	single-strand DNA-binding protein [Campy...	183	Predicted Essential	Community Requests	2VW9	35.5%	Campylobacter jejuni

IDP01940 (show subtarget assignments)	1	cloned	No	STM1626	16764970	trg	methyl-accepting chemotaxis protein III ...	541	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	35.5%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01651 (show subtarget assignments)	1	cloned	No	YPO2946	16123129	clpB5	Clp ATPase [Yersinia pestis CO92]	891	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	1QVR	35.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04187 (show subtarget assignments)	1	expressed	No	VCA0723	15601479		3-hydroxy-3-methylglutaryl CoA reductase...	436	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1DQ8	35.5%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05292 (show subtarget assignments)	1	cloned	No	CD1600	126699204	thiK	hydroxyethylthiazole kinase [Clostridium...	262	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3HPD	35.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00731 (show subtarget assignments)	1	purified	No	SACOL2462	57286457		ABC transporter, ATP-binding protein	220	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP90507 (show subtarget assignments)	8	soluble	No	VC2270	15642268		riboflavin synthase subunit alpha [Vibri...	217	Predicted Essential	Community Requests	1KZL	35.5%	Vibrio cholerae

IDP05464 (show subtarget assignments)	1	expressed	No	BA_1489	30255419		superoxide dismutase [Bacillus anthracis...	304	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1P7G	35.5%	Bacillus anthracis	Cellular processes: Detoxification

IDP04613 (show subtarget assignments)	1	cloned	No	BAS3890	49186888		M20/M25/M40 family peptidase [Bacillus a...	376	Proposed to be essential proteins	Phase 4: April 2009	1YSJ	35.6%	Bacillus anthracis

IDP00031 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1078	30254808	blaI	penicillinase repressor	132	Virulence	Phase 1: October 2007	1OKR	35.6%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91970 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100005433	298255040		lipoprotein [Streptococcus pneumoniae st...	284	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P99	35.6%	Streptococcus pneumoniae

IDP04472 (show subtarget assignments)	1	selected	No	YPO2479	115348179	manB	phosphomannomutase [Yersinia pestis CO92...	462	drug target; putative drug target function;	Phase 4: April 2009	3UW2	35.6%	Yersinia pestis	Energy metabolism	Sugars

IDP02072 (show subtarget assignments)	1	soluble	No	FTT0554	56707684		hypothetical protein FTT0554 [Francisell...	90	Drug Target	Phase 3: June 2008	4ADZ	35.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP90083 (show subtarget assignments)	8	cloned	No	ZP_01795671	145640077		hypothetical protein CGSHiII_00664 [Haem...	219	The protein we would like structure analyzed is from Haemophilus influenzae. Pri...	Community Requests	2XM6	35.6%	Haemophilus influenzae

IDP01920 (show subtarget assignments)	1	expressed	No	CBU_1156	29541728	trpA	tryptophan synthase, alpha subunit [Coxi...	267	Conserved; Drug target functions	Phase 3: June 2008	1V7Y	35.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02510 (show subtarget assignments)	1	expressed	No	YPO2285	16122509		putative ribose-binding periplasmic prot...	208	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	35.6%	Yersinia pestis	N/A	N/A

IDP00448 (show subtarget assignments)	1	purified	No	YPO0646	16120971	gcp	O-sialoglycoprotein endopeptidase	337	Drug Target Function	Phase 2: March 2008	2IVN	35.6%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00445 (show subtarget assignments)	1	purified	No	YPO3843	16123978	xerC	site-specific tyrosine recombinase XerC ...	303	Conserved Gene / Pathway	Phase 2: March 2008	1A0P	35.6%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP01360 (show subtarget assignments)	1	purified	No	VC0148	15640179		cell division ATP-binding protein FtsE	233	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	35.6%	Vibrio cholerae	Cellular processes	Cell division

IDP05216 (show subtarget assignments)	1	cloned	No	CD3349	126700969	bclA3	putative exosporium glycoprotein [Clostr...	657	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	35.6%	Clostridium difficile	Unknown function: General

IDP92056 (show subtarget assignments)	8	selected	No	TGME49_059660	237831725		orotate phosphoribosyltransferase, putat...	283	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1LH0	35.7%	Toxoplasma gondii

IDP91346 (show subtarget assignments)	8	soluble	No	VV1_3141	27366406		hypothetical protein VV1_3141 [Vibrio vu...	294	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2HTA	35.7%	Vibrio vulnificus

IDP01991 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0108	16120455	cytR	DNA-binding transcriptional regulator Cy...	342	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3OQO	35.7%	Yersinia pestis	Regulatory functions	Other

IDP05035 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1300	30255245	potD	spermidine/putrescine ABC transporter, s...	345	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1POT	35.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP90590 (show subtarget assignments)	8	cloned	No	Cj0770c	15792108		lipoprotein, NLPA family [Campylobacter ...	258	Predicted Essential	Community Requests	1P99	35.7%	Campylobacter jejuni

IDP00350 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1633	16803673	trpE	anthranilate synthase component I	454	Drug Target Function	Phase 2: March 2008	1QDL	35.7%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP01361 (show subtarget assignments)	1	expressed	No	VC0157	15640187		alkaline serine protease	535	Drug Target Function	Phase 2: March 2008	1S2N	35.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91791 (show subtarget assignments)	8	in_crystallization_trials	No	AAA24789	148330	vanH	vancomycin resistance protein [Enterococ...	322	drug resistance / Dehydrogenase that reduces pyruvate to D-lactate, which is required to produce a...	Community Requests	3KB6	35.7%	Enterococcus faecium

IDP90690 (show subtarget assignments)	8	purified	No	Cj1196c	15792520	gpsA	NAD(P)H-dependent glycerol-3-phosphate d...	298	Predicted Essential	Community Requests	1Z82	35.8%	Campylobacter jejuni

IDP01000 (show subtarget assignments)	1	expressed	No	STM2389	16765716	fadI	3-ketoacyl-CoA thiolase	436	Conserved Gene / Pathway	Phase 2: March 2008	1ULQ	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00999 (show subtarget assignments)	1	expressed	No	STM2388	16765715	fadJ	multifunctional fatty acid oxidation com...	715	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP91509 (show subtarget assignments)	8	soluble	No	VP1665	28898439		putative type III secretion protein [Vib...	123	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XKP	35.8%	Vibrio parahaemolyticus

IDP02186 (show subtarget assignments)	1	soluble	No	FTT1672	56708682	ribB	riboflavin synthase subunit alpha [Franc...	201	Conserved; Drug target functions	Phase 3: June 2008	1KZL	35.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01082 (show subtarget assignments)	1	expressed	No	STM4279	16767529	nrfC	putative formate-dependent nitrite reduc...	223	Essential Gene	Phase 2: March 2008	2VPW	35.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP04139 (show subtarget assignments)	1	soluble	No	YPO2999	218930048		putative HlyD family secretion protein [...	401	putative drug target function;	Phase 4: April 2009	4DK0	35.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05160 (show subtarget assignments)	1	purified	No	BA_1349	30255287		conserved hypothetical protein [Bacillus...	256	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NLY	35.9%	Bacillus anthracis	Hypothetical proteins: Conserved

IDP92090 (show subtarget assignments)	8	selected	No	TGME49_121570	237844801		(3R)-hydroxymyristoyl ACP dehydrase, put...	231	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1Z6B	35.9%	Toxoplasma gondii

IDP92028 (show subtarget assignments)	8	selected	No	TGME49_017740	237844087		oxoacyl-ACP reductase, putative [Toxopla...	376	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C07	35.9%	Toxoplasma gondii

IDP90733 (show subtarget assignments)	8	cloned	No	Cj1001	15792328	rpoD	RNA polymerase sigma factor RpoD [Campyl...	622	Predicted Essential	Community Requests	3IYD	35.9%	Campylobacter jejuni

IDP04319 (show subtarget assignments)	1	purified	No	YPO1544	115347296	hisA	phosphoribosylformimino-5-aminoimidazole...	245	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2Y85	35.9%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP01844 (show subtarget assignments)	1	soluble	No	GBAA1428	47526700	hisH	imidazole glycerol phosphate synthase su...	209	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPW	35.9%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP04496 (show subtarget assignments)	1	expressed	No	VC0675	15640694	thyA	thymidylate synthase [Vibrio cholerae O1...	283	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3V8H	35.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP05569 (show subtarget assignments)	1	soluble	No	BAS4454	49187449	-	asparaginyl-tRNA synthetase [Bacillus an...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	35.9%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP02429 (show subtarget assignments)	1	expressed	No	FTT0723c	56707841		Short-chain dehydrogenase/reductase fami...	262	Conserved; Drug target functions	Phase 3: June 2008	4E3Z	35.9%	Francisella tularensis	Energy metabolism	Other

IDP04082
(show subtarget assignments)

1

cloned

No

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04414
(show subtarget assignments)

8

selected

No

CAC05786

12329055

sepA

SepA, extracellular serine protease of t...

1364

Shigella effector protein

Community Requests

1WXR

34.9%

Shigella flexneri

IDP02765
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2632

47527924

cytochrome P450 family protein [Bacillus...

404

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2BVJ

34.9%

Bacillus anthracis

Central intermediary metabolism

Other

IDP91254
(show subtarget assignments)

8

soluble

No

NT02SA0910

14246689

probable 2-nitropropane dioxygenase [Sta...

355

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3BW2

34.9%

Staphylococcus aureus

Cellular processes: Detoxification

IDP01258
(show subtarget assignments)

1

soluble

No

BA_2238

30256883

pbpC

penicillin-binding protein 3

661

Drug Target Function

Phase 2: March 2008

1MWR

34.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01229
(show subtarget assignments)

1

soluble

No

BA_4540

52782922

Protein grpE (HSP-70 cofactor)

188

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

34.9%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP90794
(show subtarget assignments)

8

purified

No

Cj0763c

15792101

cysE

serine acetyltransferase [Campylobacter ...

212

Predicted Essential

Community Requests

3P1B

34.9%

Campylobacter jejuni

IDP05299
(show subtarget assignments)

1

soluble

No

CD2524

126700141

nadD

nicotinate-nucleotide adenylyltransferas...

229

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KAM

34.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP90694
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0840c

15792178

fbp

fructose-1,6-bisphosphatase [Campylobact...

280

Predicted Essential

Community Requests

3IFA

34.9%

Campylobacter jejuni

IDP91621
(show subtarget assignments)

8

soluble

No

BAB35649

13361692

ECs2226

hypothetical protein [Escherichia coli O...

123

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

35%

Escherichia coli

IDP01968
(show subtarget assignments)

1

purified

No

STM1954

16765292

fliY

cystine transporter subunit [Salmonella ...

266

Conserved; Drug target functions

Phase 3: June 2008

2YLN

35%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP05558
(show subtarget assignments)

1

soluble

No

lmo1757

16803797

-

hypothetical protein lmo1757 [Listeria m...

371

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IB5

35%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP05681
(show subtarget assignments)

1

cloned

No

lmo1277

16803317

codV

hypothetical protein lmo1277 [Listeria m...

300

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1A0P

35%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Prophage functions

IDP01426
(show subtarget assignments)

1

expressed

No

VC1680

15641684

peptide ABC transporter, periplasmic pep...

540

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

35%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91637
(show subtarget assignments)

8

cloned

No

NP_215056

15607682

O-succinylbenzoic acid--CoA ligase [Myco...

362

drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...

Community Requests

3NYQ

35%

Mycobacterium tuberculosis

IDP91704
(show subtarget assignments)

8

selected

No

NP_004528

4758756

NAP1L1

nucleosome assembly protein 1-like 1 [Ho...

391

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2AYU

35%

Homo sapiens

IDP00608
(show subtarget assignments)

1

expressed

No

SACOL0127

57285334

phosphonate ABC transporter, ATP-binding...

257

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35%

Staphylococcus aureus

Transport and binding proteins

Other

IDP02747
(show subtarget assignments)

1

soluble

No

FTT0147

56707317

gcp

O-sialoglycoprotein endopeptidase [Franc...

336

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2IVN

35.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00985
(show subtarget assignments)

1

soluble

No

STM2076

16765406

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

245

Conserved Gene / Pathway

Phase 2: March 2008

2Y85

35.1%

Salmonella enterica

Amino acid biosynthesis

Histidine family

IDP01948
(show subtarget assignments)

1

in_crystallization_trials

No

STM1931

16765272

araH

putative intracellular protease/amidase ...

185

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

4E08

35.1%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00213
(show subtarget assignments)

1

soluble

No

YPO0628

16120954

-

putative translational inhibitor protein...

134

Virulence

Phase 1: October 2007

3I7T

35.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04169
(show subtarget assignments)

1

in_crystallization_trials

No

VC2180

15642179

hemA

glutamyl-tRNA reductase [Vibrio cholerae...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPJ

35.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01703
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1317

15792640

neuB3

N-acetylneuraminic acid synthetase [Camp...

343

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

1XUU

35.1%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP91777
(show subtarget assignments)

8

purified

No

AAC33914

3513664

sul1

Sul1 dihydropteroate synthase [Escherich...

279

drug resistance / Dihydropteroate synthase (sulfonamide resistance)

Community Requests

1EYE

35.1%

Escherichia coli

IDP04517
(show subtarget assignments)

1

cloned

No

CPF_2840

110799025

ksgA

dimethyladenosine transferase [Clostridi...

285

conserved gene; putative drug target function;

Phase 4: April 2009

3FUT

35.1%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP92081
(show subtarget assignments)

8

selected

No

TGME49_106970

237845145

thymidylate kinase, putative [Toxoplasma...

273

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1E2D

35.2%

Toxoplasma gondii

IDP00508
(show subtarget assignments)

1

expressed

No

YPO1315

16121597

putative hydrolase

216

Conserved Gene / Pathway

Phase 2: March 2008

3FVV

35.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP90531
(show subtarget assignments)

8

cloned

No

Q9KSF9

20139940

RecName: Full=Asparaginyl-tRNA synthetas...

466

Predicted Essential

Community Requests

1X54

35.2%

Vibrio cholerae

IDP02625
(show subtarget assignments)

1

cloned

No

GBAA4457

47529752

aroK

shikimate kinase [Bacillus anthracis str...

165

Conserved; Drug target functions

Phase 3: June 2008

1ZUH

35.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP05490
(show subtarget assignments)

1

soluble

No

BA_5139

30259623

sodC

superoxide dismutase, Cu-Zn [Bacillus an...

179

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XTM

35.2%

Bacillus anthracis

Cellular processes: Detoxification

IDP01702
(show subtarget assignments)

1

soluble

No

GBAA0261

47525520

gcP

O-sialoglycoprotein endopeptidase [Bacil...

338

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IVN

35.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01613
(show subtarget assignments)

1

in_crystallization_trials

No

STM1927

16765269

yecG

universal stress protein UspC [Salmonell...

142

Conserved; Drug target functions

Phase 3: June 2008

1JMV

35.2%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP02780
(show subtarget assignments)

1

soluble

No

GBAA0507

47525777

NAD-dependent epimerase/dehydratase fami...

321

Conserved; Drug target functions

Phase 3: June 2008

2B69

35.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05534
(show subtarget assignments)

1

in_crystallization_trials

No

CD3106

126700723

putative phopho-sugar aldolase [Clostrid...

213

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3R8R

35.2%

Clostridium difficile

Unknown function: General

IDP00525
(show subtarget assignments)

1

cloned

No

YPMT1.83

16082875

caf1A

putative F1 capsule anchoring protein

833

Virulence Associated Factor

Phase 2: March 2008

3RFZ

35.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02004
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0994c

56708086

MRP like protein [Francisella tularensis...

286

Conserved; Drug target functions

Phase 3: June 2008

2PH1

35.3%

Francisella tularensis

Cellular processes

Cell division

IDP02557
(show subtarget assignments)

1

purified

No

Cj0061c

15791453

fliA

flagellar biosynthesis sigma factor [Cam...

238

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1RP3

35.3%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP00981
(show subtarget assignments)

1

in_crystallization_trials

No

STM2052

16765382

pduQ

propanol dehydrogenase

370

Conserved Gene / Pathway

Phase 2: March 2008

3OWO

35.3%

Salmonella enterica

Energy metabolism

Fermentation

IDP92132
(show subtarget assignments)

8

selected

No

TGME49_053290

237840177

valyl-tRNA synthetase, putative [Toxopla...

1042

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1GAX

35.3%

Toxoplasma gondii

IDP01814
(show subtarget assignments)

1

expressed

No

STM1753

16765097

hnr

response regulator of RpoS [Salmonella t...

337

Conserved; Drug target functions

Phase 3: June 2008

3EOD

35.3%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02284
(show subtarget assignments)

1

soluble

No

CBU_1293

29541861

grpE

heat shock protein GrpE [Coxiella burnet...

204

Conserved; Drug target functions

Phase 3: June 2008

1DKG

35.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP05574
(show subtarget assignments)

1

soluble

No

SACOL0533

57651372

metS

methionyl-tRNA synthetase [Staphylococcu...

657

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2CSX

35.3%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP00433
(show subtarget assignments)

1

purified

No

YPO1545

16121818

hisH

imidazole glycerol phosphate synthase su...

196

Drug Target Function

Phase 2: March 2008

1GPW

35.3%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP01615
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0643

29541244

ribD

riboflavin biosynthesis protein RibD [Co...

354

Conserved; Drug target functions

Phase 3: June 2008

2HXV

35.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04211
(show subtarget assignments)

1

expressed

No

STM0408_1_323

16763788

secF

preprotein translocase subunit SecF [Sal...

323

Salmonella essential protein

Phase 4: April 2009

3AQP

35.3%

Salmonella enterica

IDP00345
(show subtarget assignments)

1

cloned

No

lmo0441

16802485

hypothetical protein lmo0441

678

Drug Target Function

Phase 2: March 2008

1MWR

35.3%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05644
(show subtarget assignments)

1

cloned

No

CD3230

126700850

bclA2

exosporium glycoprotein [Clostridium dif...

558

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

35.3%

Clostridium difficile

Unclassified: Role category not yet assigned

IDP00062
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4511

50400989

4-hydroxy-3-methylbut-2-enyl diphosphate...

316

Virulence

Phase 1: October 2007

3F7T

35.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02079
(show subtarget assignments)

1

expressed

No

Cj0173c

15791560

iron ABC transporter, ATP binding subuni...

302

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2D62

35.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01797
(show subtarget assignments)

1

cloned

No

CBU_1008

29541590

bioA

adenosylmethionine-8-amino-7-oxononanoat...

442

Conserved; Drug target functions

Phase 3: June 2008

3DOD

35.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01763
(show subtarget assignments)

1

cloned

No

YPO3627

16123769

ssuB

aliphatic sulfonates transport ATP-bindi...

271

Conserved; CD; Drug target functions

Phase 3: June 2008

2IT1

35.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP05320
(show subtarget assignments)

1

cloned

No

lmo0177

16802223

metS

methionyl-tRNA synthetase [Listeria mono...

630

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2CSX

35.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP91971
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100002131

298254398

lipoprotein [Streptococcus pneumoniae st...

350

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2FQW

35.4%

Streptococcus pneumoniae

IDP91172
(show subtarget assignments)

8

purified

No

PA1706

15596903

pcrV

type III secretion protein PcrV [Pseudom...

294

potential drug target / P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...

Community Requests

1R6F

35.4%

Pseudomonas aeruginosa

IDP90716
(show subtarget assignments)

8

soluble

No

Cj0576

15791936

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

321

Predicted Essential

Community Requests

2IU8

35.5%

Campylobacter jejuni

IDP91950
(show subtarget assignments)

8

selected

No

SpneCM_010100006639

298255269

beta-N-acetylhexosaminidase [Streptococc...

1312

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3RPM

35.5%

Streptococcus pneumoniae

IDP90534
(show subtarget assignments)

8

cloned

No

Cj1071

15792396

ssb

single-strand DNA-binding protein [Campy...

183

Predicted Essential

Community Requests

2VW9

35.5%

Campylobacter jejuni

IDP01940
(show subtarget assignments)

1

cloned

No

STM1626

16764970

trg

methyl-accepting chemotaxis protein III ...

541

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

35.5%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01651
(show subtarget assignments)

1

cloned

No

YPO2946

16123129

clpB5

Clp ATPase [Yersinia pestis CO92]

891

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

1QVR

35.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04187
(show subtarget assignments)

1

expressed

No

VCA0723

15601479

3-hydroxy-3-methylglutaryl CoA reductase...

436

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1DQ8

35.5%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05292
(show subtarget assignments)

1

cloned

No

CD1600

126699204

thiK

hydroxyethylthiazole kinase [Clostridium...

262

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3HPD

35.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00731
(show subtarget assignments)

1

purified

No

SACOL2462

57286457

ABC transporter, ATP-binding protein

220

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP90507
(show subtarget assignments)

8

soluble

No

VC2270

15642268

riboflavin synthase subunit alpha [Vibri...

217

Predicted Essential

Community Requests

1KZL

35.5%

Vibrio cholerae

IDP05464
(show subtarget assignments)

1

expressed

No

BA_1489

30255419

superoxide dismutase [Bacillus anthracis...

304

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1P7G

35.5%

Bacillus anthracis

Cellular processes: Detoxification

IDP04613
(show subtarget assignments)

1

cloned

No

BAS3890

49186888

M20/M25/M40 family peptidase [Bacillus a...

376

Proposed to be essential proteins

Phase 4: April 2009

1YSJ

35.6%

Bacillus anthracis

IDP00031
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1078

30254808

blaI

penicillinase repressor

132

Virulence

Phase 1: October 2007

1OKR

35.6%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91970
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100005433

298255040

lipoprotein [Streptococcus pneumoniae st...

284

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P99

35.6%

Streptococcus pneumoniae

IDP04472
(show subtarget assignments)

1

selected

No

YPO2479

115348179

manB

phosphomannomutase [Yersinia pestis CO92...

462

drug target; putative drug target function;

Phase 4: April 2009

3UW2

35.6%

Yersinia pestis

Energy metabolism

Sugars

IDP02072
(show subtarget assignments)

1

soluble

No

FTT0554

56707684

hypothetical protein FTT0554 [Francisell...

90

Drug Target

Phase 3: June 2008

4ADZ

35.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP90083
(show subtarget assignments)

8

cloned

No

ZP_01795671

145640077

hypothetical protein CGSHiII_00664 [Haem...

219

The protein we would like structure analyzed is from Haemophilus influenzae. Pri...

Community Requests

2XM6

35.6%

Haemophilus influenzae

IDP01920
(show subtarget assignments)

1

expressed

No

CBU_1156

29541728

trpA

tryptophan synthase, alpha subunit [Coxi...

267

Conserved; Drug target functions

Phase 3: June 2008

1V7Y

35.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02510
(show subtarget assignments)

1

expressed

No

YPO2285

16122509

putative ribose-binding periplasmic prot...

208

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

35.6%

Yersinia pestis

N/A

IDP00448
(show subtarget assignments)

1

purified

No

YPO0646

16120971

gcp

O-sialoglycoprotein endopeptidase

337

Drug Target Function

Phase 2: March 2008

2IVN

35.6%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00445
(show subtarget assignments)

1

purified

No

YPO3843

16123978

xerC

site-specific tyrosine recombinase XerC ...

303

Conserved Gene / Pathway

Phase 2: March 2008

1A0P

35.6%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP01360
(show subtarget assignments)

1

purified

No

VC0148

15640179

cell division ATP-binding protein FtsE

233

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

35.6%

Vibrio cholerae

Cellular processes

Cell division

IDP05216
(show subtarget assignments)

1

cloned

No

CD3349

126700969

bclA3

putative exosporium glycoprotein [Clostr...

657

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

35.6%

Clostridium difficile

Unknown function: General

IDP92056
(show subtarget assignments)

8

selected

No

TGME49_059660

237831725

orotate phosphoribosyltransferase, putat...

283

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1LH0

35.7%

Toxoplasma gondii

IDP91346
(show subtarget assignments)

8

soluble

No

VV1_3141

27366406

hypothetical protein VV1_3141 [Vibrio vu...

294

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2HTA

35.7%

Vibrio vulnificus

IDP01991
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0108

16120455

cytR

DNA-binding transcriptional regulator Cy...

342

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3OQO

35.7%

Yersinia pestis

Regulatory functions

Other

IDP05035
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1300

30255245

potD

spermidine/putrescine ABC transporter, s...

345

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1POT

35.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP90590
(show subtarget assignments)

8

cloned

No

Cj0770c

15792108

lipoprotein, NLPA family [Campylobacter ...

258

Predicted Essential

Community Requests

1P99

35.7%

Campylobacter jejuni

IDP00350
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1633

16803673

trpE

anthranilate synthase component I

454

Drug Target Function

Phase 2: March 2008

1QDL

35.7%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP01361
(show subtarget assignments)

1

expressed

No

VC0157

15640187

alkaline serine protease

535

Drug Target Function

Phase 2: March 2008

1S2N

35.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91791
(show subtarget assignments)

8

in_crystallization_trials

No

AAA24789

148330

vanH

vancomycin resistance protein [Enterococ...

322

drug resistance / Dehydrogenase that reduces pyruvate to D-lactate, which is required to produce a...

Community Requests

3KB6

35.7%

Enterococcus faecium

IDP90690
(show subtarget assignments)

8

purified

No

Cj1196c

15792520

gpsA

NAD(P)H-dependent glycerol-3-phosphate d...

298

Predicted Essential

Community Requests

1Z82

35.8%

Campylobacter jejuni

IDP01000
(show subtarget assignments)

1

expressed

No

STM2389

16765716

fadI

3-ketoacyl-CoA thiolase

436

Conserved Gene / Pathway

Phase 2: March 2008

1ULQ

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00999
(show subtarget assignments)

1

expressed

No

STM2388

16765715

fadJ

multifunctional fatty acid oxidation com...

715

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP91509
(show subtarget assignments)

8

soluble

No

VP1665

28898439

putative type III secretion protein [Vib...

123

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XKP

35.8%

Vibrio parahaemolyticus

IDP02186
(show subtarget assignments)

1

soluble

No

FTT1672

56708682

ribB

riboflavin synthase subunit alpha [Franc...

201

Conserved; Drug target functions

Phase 3: June 2008

1KZL

35.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01082
(show subtarget assignments)

1

expressed

No

STM4279

16767529

nrfC

putative formate-dependent nitrite reduc...

223

Essential Gene

Phase 2: March 2008

2VPW

35.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP04139
(show subtarget assignments)

1

soluble

No

YPO2999

218930048

putative HlyD family secretion protein [...

401

putative drug target function;

Phase 4: April 2009

4DK0

35.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05160
(show subtarget assignments)

1

purified

No

BA_1349

30255287

conserved hypothetical protein [Bacillus...

256

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NLY

35.9%

Bacillus anthracis

Hypothetical proteins: Conserved

IDP92090
(show subtarget assignments)

8

selected

No

TGME49_121570

237844801

(3R)-hydroxymyristoyl ACP dehydrase, put...

231

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1Z6B

35.9%

Toxoplasma gondii

IDP92028
(show subtarget assignments)

8

selected

No

TGME49_017740

237844087

oxoacyl-ACP reductase, putative [Toxopla...

376

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C07

35.9%

Toxoplasma gondii

IDP90733
(show subtarget assignments)

8

cloned

No

Cj1001

15792328

rpoD

RNA polymerase sigma factor RpoD [Campyl...

622

Predicted Essential

Community Requests

3IYD

35.9%

Campylobacter jejuni

IDP04319
(show subtarget assignments)

1

purified

No

YPO1544

115347296

hisA

phosphoribosylformimino-5-aminoimidazole...

245

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2Y85

35.9%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP01844
(show subtarget assignments)

1

soluble

No

GBAA1428

47526700

hisH

imidazole glycerol phosphate synthase su...

209

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPW

35.9%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP04496
(show subtarget assignments)

1

expressed

No

VC0675

15640694

thyA

thymidylate synthase [Vibrio cholerae O1...

283

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3V8H

35.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP05569
(show subtarget assignments)

1

soluble

No

BAS4454

49187449

-

asparaginyl-tRNA synthetase [Bacillus an...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

35.9%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP02429
(show subtarget assignments)

1

expressed

No

FTT0723c

56707841

Short-chain dehydrogenase/reductase fami...

262

Conserved; Drug target functions

Phase 3: June 2008

4E3Z

35.9%

Francisella tularensis

Energy metabolism

Other