Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05174 (show subtarget assignments)	1	cloned	No	BA_2570	30257192		conserved hypothetical protein [Bacillus...	245	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP01028 (show subtarget assignments)	1	in_crystallization_trials	No	STM1707	16765051	pyrF	orotidine 5'-phosphate decarboxylase	245	Essential Gene	Phase 2: March 2008	1EIX	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00530 (show subtarget assignments)	1	cloned	No	YPO2736	16122940	ccmC	putative heme exporter protein C	245	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cellular processes	Other

IDP05613 (show subtarget assignments)	1	expressed	No	BA_5436	30259904		putative polysaccharide deacetylase [Bac...	245	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	29%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00985 (show subtarget assignments)	1	soluble	No	STM2076	16765406	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	245	Conserved Gene / Pathway	Phase 2: March 2008	2Y85	35.1%	Salmonella enterica	Amino acid biosynthesis	Histidine family

IDP92069 (show subtarget assignments)	8	selected	No	TGME49_081920	237844207		vacuolar ATP synthase subunit D, putativ...	245	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3A5C	29.8%	Toxoplasma gondii

IDP92054 (show subtarget assignments)	8	selected	No	TGME49_058150	237831483		proteasome subunit alpha type 7, putativ...	245	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3UNE	52%	Toxoplasma gondii

IDP05510 (show subtarget assignments)	1	soluble	No	CD1303	126698901		NAD-dependent deacetylase [Clostridium d...	245	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MA3	40.8%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04319 (show subtarget assignments)	1	purified	No	YPO1544	115347296	hisA	phosphoribosylformimino-5-aminoimidazole...	245	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2Y85	35.9%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP04102 (show subtarget assignments)	1	cloned	No	YPO2227	218929324	pyrF	orotidine 5'-phosphate decarboxylase [Ye...	245	conserved gene; putative drug target function;	Phase 4: April 2009	1EIX	72.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04607 (show subtarget assignments)	1	cloned	No	BAS3700	49186699		ribonuclease III [Bacillus anthracis str...	245	Proposed to be essential proteins	Phase 4: April 2009	1O0W	40%	Bacillus anthracis

IDP01355 (show subtarget assignments)	1	soluble	No	VC0008	15640040		amino acid ABC transporter, ATP-binding ...	245	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	51.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01254 (show subtarget assignments)	1	in_pdb 4ECM 3HL3	Yes	BA_1228	30255177		glucose-1-phosphate thymidylyltransferas...	245	Conserved Gene / Pathway	Phase 2: March 2008	3HL3	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0197	30253704		pyrroline-5-carboxylate reductase, putat...	245	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3TRI	33.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01206 (show subtarget assignments)	1	purified	No	BA_2446	30257076		N-acetylmuramoyl-L-alanine amidase, fami...	245	Conserved Gene / Pathway	Phase 2: March 2008	1XOV	26.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90258 (show subtarget assignments)	8	in_pdb 3KY7	No	SAR1216	49483403	trmD	putative tRNA (guanine-7-)-methyltransfe...	245	Potential drug target	Community Requests	3KY7	100%	Staphylococcus aureus

IDP01086 (show subtarget assignments)	1	in_crystallization_trials	No	STM4404	16767650	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphos...	246	Conserved Gene / Pathway	Phase 2: March 2008	3B8B	48.1%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP91282 (show subtarget assignments)	8	cloned	No	NT05BA5499	49182184		glycosyl transferase, WecB/TagA/CpsF fam...	246	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Bacillus anthracis	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02804 (show subtarget assignments)	1	cloned	No	lmo2181	16804220		hypothetical protein lmo2181 [Listeria m...	246	Known virulence-Surface protein anchoring; Predicted virulence-Iron Scavenging M...	Phase 3: June 2008	1RZ2	46.2%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP92008 (show subtarget assignments)	8	selected	No	ACU65240	256260269		mutant IMP-1 metallo-beta-lactamase [syn...	246	drug resistance / 256260269: We have characterized this metallo-beta-lactamase variant biochemical...	Community Requests	1DD6	92.3%	synthetic construct

IDP01988 (show subtarget assignments)	1	cloned	No	Cj1032	15792359		hypothetical protein Cj1032 [Campylobact...	246	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	4DK1	19.1%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP91909 (show subtarget assignments)	8	selected	No	SpneCM_010100002785	298254524		cell wall surface anchor family protein,...	246	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP90844 (show subtarget assignments)	8	in_pdb 3P52	Yes	Cj0810	15792148	nadE	NAD+ synthetase [Campylobacter jejuni su...	246	Predicted Essential	Community Requests	3P52	100%	Campylobacter jejuni

IDP04726 (show subtarget assignments)	1	cloned	No	YPO1565	218928703		putative oxidoreductase [Yersinia pestis...	246	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2AG5	56.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91221 (show subtarget assignments)	8	soluble	No	SAV1231	15924221	fabG	3-oxoacyl-(acyl-carrier protein) reducta...	246	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3OSU	100%	Staphylococcus aureus

IDP02505 (show subtarget assignments)	1	in_pdb 3QAO	No	lmo0526	16802569		hypothetical protein lmo0526 [Listeria m...	246	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	3QAO	100%	Listeria monocytogenes	Regulatory functions	Other

IDP00781 (show subtarget assignments)	1	expressed	No	SACOL0845	57284307	est	carboxylesterase	246	Conserved Gene / Pathway	Phase 2: March 2008	1R1D	57.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP90226 (show subtarget assignments)	1	selected	No	VC2428	9657003		conserved hypothetical protein [Vibrio c...	246	Conserved gene clusters with virulence associated genes. Conserved Protein; Pred...	January 2009	2OEZ	74.8%	Vibrio cholerae

IDP90941 (show subtarget assignments)	8	expressed	No	NMPDR 214092.1.peg.4098				246	Predicted Essential	Community Requests	2PB0	66.3%	Yersinia pestis

IDP92009 (show subtarget assignments)	8	selected	No	ACU65237	256260263		mutant IMP-6 metallo-beta-lactamase [syn...	246	drug resistance / 256260263: We have biochemically characterized this metallo-beta-lactamase varia...	Community Requests	1DD6	91.9%	synthetic construct

IDP05125 (show subtarget assignments)	1	cloned	No	BA_4310	30258811		putative lipoprotein [Bacillus anthracis...	246	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05774 (show subtarget assignments)	1	in_pdb 3OSU	No	SAV1231	15924221	fabG	3-oxoacyl-(acyl-carrier protein) reducta...	246	potential drug target / Potential drug target	Phase 5: 2010	3OSU	100%	Staphylococcus aureus

IDP01233 (show subtarget assignments)	1	purified	No	BA_5335	30259811	estA	carboxylesterase	246	Drug Target Function	Phase 2: March 2008	1R1D	79.3%	Bacillus anthracis	Cellular processes	Detoxification

IDP91252 (show subtarget assignments)	8	soluble	No	NT01LM1948	16411261	fabG	fabG [Listeria monocytogenes]	247	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2UVD	66.4%	Listeria monocytogenes	Fatty acid and phospholipid metabolism: Biosynthesis

IDP92068 (show subtarget assignments)	8	selected	No	TGME49_078050	237842421		proteasome subunit alpha type 1, putativ...	247	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3UNB	50.6%	Toxoplasma gondii

IDP91992 (show subtarget assignments)	8	purified	No	SpneCM_010100001714	298254315		sortase [Streptococcus pneumoniae str. C...	247	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3FN5	42.5%	Streptococcus pneumoniae

IDP91052 (show subtarget assignments)	8	in_crystallization_trials	No	PSA0001	116063829	rmtD	16S rRNA methylase [Pseudomonas aerugino...	247	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3B89	42.5%	Pseudomonas aeruginosa

IDP05526 (show subtarget assignments)	1	soluble	No	CD1319	126698918		putative polysaccharide deacetylase [Clo...	247	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2J13	27.1%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02724 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1330	47526596	fabG	acetoacetyl-CoA reductase [Bacillus anth...	247	Essential; Drug target functions	Phase 3: June 2008	2UVD	46.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00474 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2512	16122733	glnH	glutamine ABC transporter periplasmic pr...	247	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	78.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00827 (show subtarget assignments)	1	expressed	No	SACOL2507	57285192	sarU	staphylococcal accessory regulator U	247	Conserved Gene / Pathway	Phase 2: March 2008	1P4X	37.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP05748 (show subtarget assignments)	1	cloned	No	Cj0435	6967908	fabG	phosphoglycerate mutase [Campylobacter j...	247	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2P68	48.8%	Campylobacter jejuni	Fatty acid and phospholipid metabolism: Biosynthesis

IDP91245 (show subtarget assignments)	8	soluble	No	HP0561	2313678		3-ketoacyl-acyl carrier protein reductas...	247	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3F9I	45.7%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90606 (show subtarget assignments)	8	in_crystallization_trials	No	VC0563	15640585	trmD	tRNA (guanine-N(1)-)-methyltransferase [...	247	Predicted Essential	Community Requests	1P9P	78.1%	Vibrio cholerae

IDP00334 (show subtarget assignments)	1	in_pdb 3LYL	No	FTT1375	56708428	fabG	3-oxoacyl-(acyl-carrier-protein) reducta...	247	Drug Target Function	Phase 2: March 2008	3LYL	100%	Francisella tularensis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91053 (show subtarget assignments)	8	in_crystallization_trials	No	ENC0002	0			247	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3B89	42.1%	Enterobacter cloacae

IDP91042 (show subtarget assignments)	8	in_crystallization_trials	No	ACB0002	38230268		AdeR [Acinetobacter baumannii]	247	Regulator protein of transcription of antibiotic drug-efflux pump AdeABC	Community Requests	2GWR	33.2%	Acinetobacter baumannii

IDP00609 (show subtarget assignments)	1	expressed	No	SACOL0690	57285660		ABC transporter, ATP-binding protein	247	Conserved Gene / Pathway	Phase 2: March 2008	3D31	29.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP90361 (show subtarget assignments)	8	cloned	No	CT_021	3328411		hypothetical protein [Chlamydia trachoma...	247	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00127 (show subtarget assignments)	1	soluble	No	NT01ST1705	16764721	sufC	cysteine desulfurase ATPase component	248	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2D3W	92.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP01074 (show subtarget assignments)	1	in_pdb 3FPK	Yes	STM4084	16767350	fpr	ferredoxin-NADP reductase	248	Conserved Gene / Pathway	Phase 2: March 2008	3FPK	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00264 (show subtarget assignments)	1	expressed	No	NP_056776_2244-2491	159024209	N/A	NS4B	248	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP04020 (show subtarget assignments)	1	cloned	No	CPF_2112	110800515		cell division protein FtsQ [Clostridium ...	248	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP01971 (show subtarget assignments)	1	soluble	No	STM3065	16766366	yggE	hypothetical protein STM3065 [Salmonella...	248	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00947 (show subtarget assignments)	1	purified	No	STM0988	16764348	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	248	Essential Gene	Phase 2: March 2008	1VH1	94%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90557 (show subtarget assignments)	8	in_pdb 3U09 3TZK 3TZH 3TZC 3RSH 3OP4 3RRO	No	VC2021	15642023	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	248	Predicted Essential	Community Requests	3OP4	100%	Vibrio cholerae

IDP00099 (show subtarget assignments)	0	work_stopped	No	NT02SF1983	30041448	ynhD	putative ATP-binding component of a tran...	248	Conserved; CD; Drug target functions	Phase 1: October 2007	2D3W	99.6%	Shigella flexneri	Transport and binding proteins	Unknown substrate

IDP91197 (show subtarget assignments)	8	soluble	No	BAS4345	49187340	-	stage IV sporulation protein FA	248	essential/virulence/pathogenesis / Essential proteins	Community Requests	3TUF	10.9%	Bacillus anthracis

IDP91493 (show subtarget assignments)	8	cloned	No	VP1690	28898464		putative type III secretion lipoprotein ...	248	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YJ7	23.8%	Vibrio parahaemolyticus

IDP91577 (show subtarget assignments)	8	purified	No	BAB37973	13364025	ECs4550	EspF protein [Escherichia coli O157:H7 s...	248	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP91204 (show subtarget assignments)	8	cloned	No	BT_4215	29349623		shikimate 5-dehydrogenase [Bacteroides t...	248	potential drug target / Shikimate pathway enzyme	Community Requests	2HK7	38%	Bacteroides thetaiotaomicron

IDP01356 (show subtarget assignments)	1	soluble	No	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00270 (show subtarget assignments)	1	cloned	No	AF180817_2245-2493	7329982	N/A	NS4B	249	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP02416 (show subtarget assignments)	1	purified	No	FTT1259	56708321	nadE	NH(3)-dependent NAD(+) synthetase [Franc...	249	Conserved; Drug target functions	Phase 3: June 2008	3FIU	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02099 (show subtarget assignments)	1	cloned	No	FTT0972	56708065		ABC transporter, ATP-binding protein [Fr...	249	Conserved; Drug target functions	Phase 3: June 2008	2D3W	57.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90698 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1531	15792839	dapF	diaminopimelate epimerase [Campylobacter...	249	Predicted Essential	Community Requests	3EJX	30.2%	Campylobacter jejuni

IDP01936 (show subtarget assignments)	1	cloned	No	Cj0720c	15792069	flaC	flagellin subunit protein FlaC [Campylob...	249	Known Predicted virulence-flagella; Predicted virulence-Adhesion of Campylobacte...	Phase 3: June 2008	3K8V	21.7%	Campylobacter jejuni	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP00940 (show subtarget assignments)	1	soluble	No	STM0845	16764207	moeB	molybdopterin biosynthesis protein MoeB ...	249	Conserved Gene / Pathway	Phase 2: March 2008	1JW9	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP90540 (show subtarget assignments)	8	in_pdb 3THA	No	Cj0349	15791717	trpA	tryptophan synthase subunit alpha [Campy...	249	Predicted Essential	Community Requests	3THA	100%	Campylobacter jejuni

IDP00858 (show subtarget assignments)	1	purified	No	STM1342	16764693	btuD	vitamin B12-transporter ATPase	249	Conserved Gene / Pathway	Phase 2: March 2008	1L7V	80.3%	Salmonella enterica	Transport and binding proteins	Other

IDP01601 (show subtarget assignments)	1	expressed	No	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP90867 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3850	16123985	hemD	uroporphyrinogen-III synthase [Yersinia ...	249	Predicted Essential	Community Requests	3MW8	33.7%	Yersinia pestis

IDP01324 (show subtarget assignments)	1	cloned	No	VCA0910	15601664		tonB1 protein	249	Conserved Gene / Pathway	Phase 2: March 2008	2GRX	27.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP91453 (show subtarget assignments)	8	cloned	No	VV1_0375	27363844		chromosome segregation ATPase [Vibrio vu...	250	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91822 (show subtarget assignments)	8	soluble	No	b0755	1786970	gpmA	phosphoglyceromutase 1 [Escherichia coli...	250	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1E59	99.6%	Escherichia coli

IDP02069 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_2017	29542571	ubiE	ubiquinone/menaquinone biosynthesis meth...	250	Conserved; Drug target functions	Phase 3: June 2008	3SM3	19.6%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02044 (show subtarget assignments)	1	expressed	No	FTT1132c	56708208	glpQ	glycerophosphoryl diester phosphodiester...	250	Drug Target	Phase 3: June 2008	1O1Z	28%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP00978 (show subtarget assignments)	1	purified	No	STM1951	16765289	yecC	putative amino-acid ABC transporter ATP-...	250	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02356 (show subtarget assignments)	1	cloned	No	FTT1296	56708355	ubiE	menaquinone biosynthesis methyltransfera...	250	Conserved; Drug target functions	Phase 3: June 2008	2AVN	20%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00961 (show subtarget assignments)	1	expressed	No	STM1385	16764735	ttrB	tetrathionate reductase complex subunit ...	250	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	34.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP02441 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1478c	56708518	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	Drug Target	Phase 3: June 2008	3TQD	51.2%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91599 (show subtarget assignments)	8	purified	No	BAB33484	13359517	ECs0061	hypothetical protein [Escherichia coli O...	250	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP05539 (show subtarget assignments)	1	in_pdb 4E16	No	CD3426	126701049	cbiF	precorrin-4 C(11)-methyltransferase [Clo...	250	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	4E16	100%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91094 (show subtarget assignments)	8	cloned	No	APL_0085	126096365	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	1VH3	70.6%	Actinobacillus pleuropneumoniae

IDP91402 (show subtarget assignments)	8	purified	No	VV1_1001	27364435		ABC-type amino acid transport, signal tr...	250	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GGG	31.2%	Vibrio vulnificus

IDP00190 (show subtarget assignments)	1	soluble	No	YPO0927	16121232	-	putative lipoprotein	250	Similar to Essential SALTY	Phase 1: October 2007	3C37	23.6%	Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP01641 (show subtarget assignments)	1	cloned	No	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	Phase 3: June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01458 (show subtarget assignments)	1	soluble	No	VC2418	15642415		thiol:disulfide interchange protein DsbC...	250	Drug Target Function	Phase 2: March 2008	1JZD	38.4%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP90511 (show subtarget assignments)	8	purified	No	Q9KPV6	42560015		RecName: Full=Undecaprenyl pyrophosphate...	250	Predicted Essential	Community Requests	1JP3	56%	Vibrio cholerae

IDP05489 (show subtarget assignments)	1	soluble	No	CD0106	126697677	cwlD	germination-specific N-acetylmuramoyl-L-...	250	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JWQ	25.6%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP04473 (show subtarget assignments)	1	expressed	No	YPO2624	115348316	nagD	putative N-acetylglucosamine metabolism ...	250	conserved gene; putative drug target function;	Phase 4: April 2009	2C4N	86%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP00328 (show subtarget assignments)	1	in_pdb 3UHP 3UHF 3UHO	No	Cj1652c	15792957	murI	glutamate racemase	250	Drug Target Function	Phase 2: March 2008	2JFX	53.7%	Campylobacter jejuni	Energy metabolism	Pentose phosphate pathway

IDP02236 (show subtarget assignments)	1	cloned	No	FTT1108	56708186		rRNA methyltransferase [Francisella tula...	250	Drug Target	Phase 3: June 2008	1IPA	29.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02355 (show subtarget assignments)	1	in_pdb 3JTJ	Yes	YPO1400	16121680	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3JTJ	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92062 (show subtarget assignments)	8	selected	No	AAK85305	22073900		putative glutathione/thioredoxin peroxid...	251	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2P5Q	24.7%	Toxoplasma gondii

IDP91783 (show subtarget assignments)	8	in_pdb 4EBK 4EBJ	No	AAM76670	30171089	ant4'-IIb	aminoglycoside nucleotidyltransferase [P...	251	drug resistance / Aminoglycoside nucleotidyltransferase (ant4'-IIb) gene (aminoglycoside resistanc...	Community Requests	4EBJ	98.8%	Pseudomonas aeruginosa

IDP00927 (show subtarget assignments)	1	soluble	No	STM0598	16763975	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2FWM	89.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90893 (show subtarget assignments)	8	expressed	No	YPO3781	16123915	ubiE	ubiquinone/menaquinone biosynthesis meth...	251	Predicted Essential	Community Requests	2AVN	21.9%	Yersinia pestis

IDP01789 (show subtarget assignments)	0	work_stopped	No	Cj1613c	15792918		hypothetical protein Cj1613c [Campylobac...	251	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3SWJ	98.8%	Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05174
(show subtarget assignments)

1

cloned

No

BA_2570

30257192

conserved hypothetical protein [Bacillus...

245

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP01028
(show subtarget assignments)

1

in_crystallization_trials

No

STM1707

16765051

pyrF

orotidine 5'-phosphate decarboxylase

245

Essential Gene

Phase 2: March 2008

1EIX

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00530
(show subtarget assignments)

1

cloned

No

YPO2736

16122940

ccmC

putative heme exporter protein C

245

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cellular processes

Other

IDP05613
(show subtarget assignments)

1

expressed

No

BA_5436

30259904

putative polysaccharide deacetylase [Bac...

245

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

29%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00985
(show subtarget assignments)

1

soluble

No

STM2076

16765406

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

245

Conserved Gene / Pathway

Phase 2: March 2008

2Y85

35.1%

Salmonella enterica

Amino acid biosynthesis

Histidine family

IDP92069
(show subtarget assignments)

8

selected

No

TGME49_081920

237844207

vacuolar ATP synthase subunit D, putativ...

245

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3A5C

29.8%

Toxoplasma gondii

IDP92054
(show subtarget assignments)

8

selected

No

TGME49_058150

237831483

proteasome subunit alpha type 7, putativ...

245

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3UNE

52%

Toxoplasma gondii

IDP05510
(show subtarget assignments)

1

soluble

No

CD1303

126698901

NAD-dependent deacetylase [Clostridium d...

245

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MA3

40.8%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04319
(show subtarget assignments)

1

purified

No

YPO1544

115347296

hisA

phosphoribosylformimino-5-aminoimidazole...

245

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2Y85

35.9%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP04102
(show subtarget assignments)

1

cloned

No

YPO2227

218929324

pyrF

orotidine 5'-phosphate decarboxylase [Ye...

245

conserved gene; putative drug target function;

Phase 4: April 2009

1EIX

72.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04607
(show subtarget assignments)

1

cloned

No

BAS3700

49186699

ribonuclease III [Bacillus anthracis str...

245

Proposed to be essential proteins

Phase 4: April 2009

1O0W

40%

Bacillus anthracis

IDP01355
(show subtarget assignments)

1

soluble

No

VC0008

15640040

amino acid ABC transporter, ATP-binding ...

245

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

51.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01254
(show subtarget assignments)

1

in_pdb
4ECM
3HL3

Yes

BA_1228

30255177

glucose-1-phosphate thymidylyltransferas...

245

Conserved Gene / Pathway

Phase 2: March 2008

3HL3

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0197

30253704

pyrroline-5-carboxylate reductase, putat...

245

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3TRI

33.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01206
(show subtarget assignments)

1

purified

No

BA_2446

30257076

N-acetylmuramoyl-L-alanine amidase, fami...

245

Conserved Gene / Pathway

Phase 2: March 2008

1XOV

26.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90258
(show subtarget assignments)

8

in_pdb
3KY7

No

SAR1216

49483403

trmD

putative tRNA (guanine-7-)-methyltransfe...

245

Potential drug target

Community Requests

3KY7

100%

Staphylococcus aureus

IDP01086
(show subtarget assignments)

1

in_crystallization_trials

No

STM4404

16767650

cysQ

PAPS (adenosine 3'-phosphate 5'-phosphos...

246

Conserved Gene / Pathway

Phase 2: March 2008

3B8B

48.1%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP91282
(show subtarget assignments)

8

cloned

No

NT05BA5499

49182184

glycosyl transferase, WecB/TagA/CpsF fam...

246

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Bacillus anthracis

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02804
(show subtarget assignments)

1

cloned

No

lmo2181

16804220

hypothetical protein lmo2181 [Listeria m...

246

Known virulence-Surface protein anchoring; Predicted virulence-Iron Scavenging M...

Phase 3: June 2008

1RZ2

46.2%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP92008
(show subtarget assignments)

8

selected

No

ACU65240

256260269

mutant IMP-1 metallo-beta-lactamase [syn...

246

drug resistance / 256260269: We have characterized this metallo-beta-lactamase variant biochemical...

Community Requests

1DD6

92.3%

synthetic construct

IDP01988
(show subtarget assignments)

1

cloned

No

Cj1032

15792359

hypothetical protein Cj1032 [Campylobact...

246

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

4DK1

19.1%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP91909
(show subtarget assignments)

8

selected

No

SpneCM_010100002785

298254524

cell wall surface anchor family protein,...

246

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP90844
(show subtarget assignments)

8

in_pdb
3P52

Yes

Cj0810

15792148

nadE

NAD+ synthetase [Campylobacter jejuni su...

246

Predicted Essential

Community Requests

3P52

100%

Campylobacter jejuni

IDP04726
(show subtarget assignments)

1

cloned

No

YPO1565

218928703

putative oxidoreductase [Yersinia pestis...

246

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2AG5

56.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91221
(show subtarget assignments)

8

soluble

No

SAV1231

15924221

fabG

3-oxoacyl-(acyl-carrier protein) reducta...

246

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3OSU

100%

Staphylococcus aureus

IDP02505
(show subtarget assignments)

1

in_pdb
3QAO

No

lmo0526

16802569

hypothetical protein lmo0526 [Listeria m...

246

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

3QAO

100%

Listeria monocytogenes

Regulatory functions

Other

IDP00781
(show subtarget assignments)

1

expressed

No

SACOL0845

57284307

est

carboxylesterase

246

Conserved Gene / Pathway

Phase 2: March 2008

1R1D

57.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP90226
(show subtarget assignments)

1

selected

No

VC2428

9657003

conserved hypothetical protein [Vibrio c...

246

Conserved gene clusters with virulence associated genes. Conserved Protein; Pred...

January 2009

2OEZ

74.8%

Vibrio cholerae

IDP90941
(show subtarget assignments)

8

expressed

No

NMPDR 214092.1.peg.4098

246

Predicted Essential

Community Requests

2PB0

66.3%

Yersinia pestis

IDP92009
(show subtarget assignments)

8

selected

No

ACU65237

256260263

mutant IMP-6 metallo-beta-lactamase [syn...

246

drug resistance / 256260263: We have biochemically characterized this metallo-beta-lactamase varia...

Community Requests

1DD6

91.9%

synthetic construct

IDP05125
(show subtarget assignments)

1

cloned

No

BA_4310

30258811

putative lipoprotein [Bacillus anthracis...

246

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05774
(show subtarget assignments)

1

in_pdb
3OSU

No

SAV1231

15924221

fabG

3-oxoacyl-(acyl-carrier protein) reducta...

246

potential drug target / Potential drug target

Phase 5: 2010

3OSU

100%

Staphylococcus aureus

IDP01233
(show subtarget assignments)

1

purified

No

BA_5335

30259811

estA

carboxylesterase

246

Drug Target Function

Phase 2: March 2008

1R1D

79.3%

Bacillus anthracis

Cellular processes

Detoxification

IDP91252
(show subtarget assignments)

8

soluble

No

NT01LM1948

16411261

fabG

fabG [Listeria monocytogenes]

247

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2UVD

66.4%

Listeria monocytogenes

Fatty acid and phospholipid metabolism: Biosynthesis

IDP92068
(show subtarget assignments)

8

selected

No

TGME49_078050

237842421

proteasome subunit alpha type 1, putativ...

247

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3UNB

50.6%

Toxoplasma gondii

IDP91992
(show subtarget assignments)

8

purified

No

SpneCM_010100001714

298254315

sortase [Streptococcus pneumoniae str. C...

247

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3FN5

42.5%

Streptococcus pneumoniae

IDP91052
(show subtarget assignments)

8

in_crystallization_trials

No

PSA0001

116063829

rmtD

16S rRNA methylase [Pseudomonas aerugino...

247

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3B89

42.5%

Pseudomonas aeruginosa

IDP05526
(show subtarget assignments)

1

soluble

No

CD1319

126698918

putative polysaccharide deacetylase [Clo...

247

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2J13

27.1%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02724
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1330

47526596

fabG

acetoacetyl-CoA reductase [Bacillus anth...

247

Essential; Drug target functions

Phase 3: June 2008

2UVD

46.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00474
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2512

16122733

glnH

glutamine ABC transporter periplasmic pr...

247

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

78.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00827
(show subtarget assignments)

1

expressed

No

SACOL2507

57285192

sarU

staphylococcal accessory regulator U

247

Conserved Gene / Pathway

Phase 2: March 2008

1P4X

37.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP05748
(show subtarget assignments)

1

cloned

No

Cj0435

6967908

fabG

phosphoglycerate mutase [Campylobacter j...

247

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2P68

48.8%

Campylobacter jejuni

Fatty acid and phospholipid metabolism: Biosynthesis

IDP91245
(show subtarget assignments)

8

soluble

No

HP0561

2313678

3-ketoacyl-acyl carrier protein reductas...

247

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3F9I

45.7%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90606
(show subtarget assignments)

8

in_crystallization_trials

No

VC0563

15640585

trmD

tRNA (guanine-N(1)-)-methyltransferase [...

247

Predicted Essential

Community Requests

1P9P

78.1%

Vibrio cholerae

IDP00334
(show subtarget assignments)

1

in_pdb
3LYL

No

FTT1375

56708428

fabG

3-oxoacyl-(acyl-carrier-protein) reducta...

247

Drug Target Function

Phase 2: March 2008

3LYL

100%

Francisella tularensis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91053
(show subtarget assignments)

8

in_crystallization_trials

No

ENC0002

0

247

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3B89

42.1%

Enterobacter cloacae

IDP91042
(show subtarget assignments)

8

in_crystallization_trials

No

ACB0002

38230268

AdeR [Acinetobacter baumannii]

247

Regulator protein of transcription of antibiotic drug-efflux pump AdeABC

Community Requests

2GWR

33.2%

Acinetobacter baumannii

IDP00609
(show subtarget assignments)

1

expressed

No

SACOL0690

57285660

ABC transporter, ATP-binding protein

247

Conserved Gene / Pathway

Phase 2: March 2008

3D31

29.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP90361
(show subtarget assignments)

8

cloned

No

CT_021

3328411

hypothetical protein [Chlamydia trachoma...

247

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00127
(show subtarget assignments)

1

soluble

No

NT01ST1705

16764721

sufC

cysteine desulfurase ATPase component

248

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2D3W

92.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP01074
(show subtarget assignments)

1

in_pdb
3FPK

Yes

STM4084

16767350

fpr

ferredoxin-NADP reductase

248

Conserved Gene / Pathway

Phase 2: March 2008

3FPK

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00264
(show subtarget assignments)

1

expressed

No

NP_056776_2244-2491

159024209

N/A

NS4B

248

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP04020
(show subtarget assignments)

1

cloned

No

CPF_2112

110800515

cell division protein FtsQ [Clostridium ...

248

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP01971
(show subtarget assignments)

1

soluble

No

STM3065

16766366

yggE

hypothetical protein STM3065 [Salmonella...

248

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00947
(show subtarget assignments)

1

purified

No

STM0988

16764348

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

248

Essential Gene

Phase 2: March 2008

1VH1

94%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90557
(show subtarget assignments)

8

in_pdb
3U09
3TZK
3TZH
3TZC
3RSH
3OP4
3RRO

No

VC2021

15642023

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

248

Predicted Essential

Community Requests

3OP4

100%

Vibrio cholerae

IDP00099
(show subtarget assignments)

0

work_stopped

No

NT02SF1983

30041448

ynhD

putative ATP-binding component of a tran...

248

Conserved; CD; Drug target functions

Phase 1: October 2007

2D3W

99.6%

Shigella flexneri

Transport and binding proteins

Unknown substrate

IDP91197
(show subtarget assignments)

8

soluble

No

BAS4345

49187340

-

stage IV sporulation protein FA

248

essential/virulence/pathogenesis / Essential proteins

Community Requests

3TUF

10.9%

Bacillus anthracis

IDP91493
(show subtarget assignments)

8

cloned

No

VP1690

28898464

putative type III secretion lipoprotein ...

248

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YJ7

23.8%

Vibrio parahaemolyticus

IDP91577
(show subtarget assignments)

8

purified

No

BAB37973

13364025

ECs4550

EspF protein [Escherichia coli O157:H7 s...

248

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP91204
(show subtarget assignments)

8

cloned

No

BT_4215

29349623

shikimate 5-dehydrogenase [Bacteroides t...

248

potential drug target / Shikimate pathway enzyme

Community Requests

2HK7

38%

Bacteroides thetaiotaomicron

IDP01356
(show subtarget assignments)

1

soluble

No

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00270
(show subtarget assignments)

1

cloned

No

AF180817_2245-2493

7329982

N/A

NS4B

249

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP02416
(show subtarget assignments)

1

purified

No

FTT1259

56708321

nadE

NH(3)-dependent NAD(+) synthetase [Franc...

249

Conserved; Drug target functions

Phase 3: June 2008

3FIU

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02099
(show subtarget assignments)

1

cloned

No

FTT0972

56708065

ABC transporter, ATP-binding protein [Fr...

249

Conserved; Drug target functions

Phase 3: June 2008

2D3W

57.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90698
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1531

15792839

dapF

diaminopimelate epimerase [Campylobacter...

249

Predicted Essential

Community Requests

3EJX

30.2%

Campylobacter jejuni

IDP01936
(show subtarget assignments)

1

cloned

No

Cj0720c

15792069

flaC

flagellin subunit protein FlaC [Campylob...

249

Known Predicted virulence-flagella; Predicted virulence-Adhesion of Campylobacte...

Phase 3: June 2008

3K8V

21.7%

Campylobacter jejuni

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP00940
(show subtarget assignments)

1

soluble

No

STM0845

16764207

moeB

molybdopterin biosynthesis protein MoeB ...

249

Conserved Gene / Pathway

Phase 2: March 2008

1JW9

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP90540
(show subtarget assignments)

8

in_pdb
3THA

No

Cj0349

15791717

trpA

tryptophan synthase subunit alpha [Campy...

249

Predicted Essential

Community Requests

3THA

100%

Campylobacter jejuni

IDP00858
(show subtarget assignments)

1

purified

No

STM1342

16764693

btuD

vitamin B12-transporter ATPase

249

Conserved Gene / Pathway

Phase 2: March 2008

1L7V

80.3%

Salmonella enterica

Transport and binding proteins

Other

IDP01601
(show subtarget assignments)

1

expressed

No

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP90867
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3850

16123985

hemD

uroporphyrinogen-III synthase [Yersinia ...

249

Predicted Essential

Community Requests

3MW8

33.7%

Yersinia pestis

IDP01324
(show subtarget assignments)

1

cloned

No

VCA0910

15601664

tonB1 protein

249

Conserved Gene / Pathway

Phase 2: March 2008

2GRX

27.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP91453
(show subtarget assignments)

8

cloned

No

VV1_0375

27363844

chromosome segregation ATPase [Vibrio vu...

250

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91822
(show subtarget assignments)

8

soluble

No

b0755

1786970

gpmA

phosphoglyceromutase 1 [Escherichia coli...

250

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1E59

99.6%

Escherichia coli

IDP02069
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_2017

29542571

ubiE

ubiquinone/menaquinone biosynthesis meth...

250

Conserved; Drug target functions

Phase 3: June 2008

3SM3

19.6%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02044
(show subtarget assignments)

1

expressed

No

FTT1132c

56708208

glpQ

glycerophosphoryl diester phosphodiester...

250

Drug Target

Phase 3: June 2008

1O1Z

28%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP00978
(show subtarget assignments)

1

purified

No

STM1951

16765289

yecC

putative amino-acid ABC transporter ATP-...

250

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02356
(show subtarget assignments)

1

cloned

No

FTT1296

56708355

ubiE

menaquinone biosynthesis methyltransfera...

250

Conserved; Drug target functions

Phase 3: June 2008

2AVN

20%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00961
(show subtarget assignments)

1

expressed

No

STM1385

16764735

ttrB

tetrathionate reductase complex subunit ...

250

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

34.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP02441
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1478c

56708518

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

Drug Target

Phase 3: June 2008

3TQD

51.2%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91599
(show subtarget assignments)

8

purified

No

BAB33484

13359517

ECs0061

hypothetical protein [Escherichia coli O...

250

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP05539
(show subtarget assignments)

1

in_pdb
4E16

No

CD3426

126701049

cbiF

precorrin-4 C(11)-methyltransferase [Clo...

250

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

4E16

100%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91094
(show subtarget assignments)

8

cloned

No

APL_0085

126096365

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

1VH3

70.6%

Actinobacillus pleuropneumoniae

IDP91402
(show subtarget assignments)

8

purified

No

VV1_1001

27364435

ABC-type amino acid transport, signal tr...

250

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GGG

31.2%

Vibrio vulnificus

IDP00190
(show subtarget assignments)

1

soluble

No

YPO0927

16121232

-

putative lipoprotein

250

Similar to Essential SALTY

Phase 1: October 2007

3C37

23.6%

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP01641
(show subtarget assignments)

1

cloned

No

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

Phase 3: June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01458
(show subtarget assignments)

1

soluble

No

VC2418

15642415

thiol:disulfide interchange protein DsbC...

250

Drug Target Function

Phase 2: March 2008

1JZD

38.4%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP90511
(show subtarget assignments)

8

purified

No

Q9KPV6

42560015

RecName: Full=Undecaprenyl pyrophosphate...

250

Predicted Essential

Community Requests

1JP3

56%

Vibrio cholerae

IDP05489
(show subtarget assignments)

1

soluble

No

CD0106

126697677

cwlD

germination-specific N-acetylmuramoyl-L-...

250

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JWQ

25.6%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP04473
(show subtarget assignments)

1

expressed

No

YPO2624

115348316

nagD

putative N-acetylglucosamine metabolism ...

250

conserved gene; putative drug target function;

Phase 4: April 2009

2C4N

86%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP00328
(show subtarget assignments)

1

in_pdb
3UHP
3UHF
3UHO

No

Cj1652c

15792957

murI

glutamate racemase

250

Drug Target Function

Phase 2: March 2008

2JFX

53.7%

Campylobacter jejuni

Energy metabolism

Pentose phosphate pathway

IDP02236
(show subtarget assignments)

1

cloned

No

FTT1108

56708186

rRNA methyltransferase [Francisella tula...

250

Drug Target

Phase 3: June 2008

1IPA

29.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02355
(show subtarget assignments)

1

in_pdb
3JTJ

Yes

YPO1400

16121680

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3JTJ

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92062
(show subtarget assignments)

8

selected

No

AAK85305

22073900

putative glutathione/thioredoxin peroxid...

251

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2P5Q

24.7%

Toxoplasma gondii

IDP91783
(show subtarget assignments)

8

in_pdb
4EBK
4EBJ

No

AAM76670

30171089

ant4'-IIb

aminoglycoside nucleotidyltransferase [P...

251

drug resistance / Aminoglycoside nucleotidyltransferase (ant4'-IIb) gene (aminoglycoside resistanc...

Community Requests

4EBJ

98.8%

Pseudomonas aeruginosa

IDP00927
(show subtarget assignments)

1

soluble

No

STM0598

16763975

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2FWM

89.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90893
(show subtarget assignments)

8

expressed

No

YPO3781

16123915

ubiE

ubiquinone/menaquinone biosynthesis meth...

251

Predicted Essential

Community Requests

2AVN

21.9%

Yersinia pestis

IDP01789
(show subtarget assignments)

0

work_stopped

No

Cj1613c

15792918

hypothetical protein Cj1613c [Campylobac...

251

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3SWJ

98.8%

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other