Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00897 (show subtarget assignments)	1	expressed	No	STM0771	16764135		putative ABC-type cobalamin/Fe3+-siderop...	258	Conserved Gene / Pathway	Phase 2: March 2008	2ONK	32.2%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP02347 (show subtarget assignments)	1	soluble	No	YPO1783	16122037	ftnA	ferritin [Yersinia pestis CO92]	169	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QZ3	68.6%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01818 (show subtarget assignments)	1	soluble	No	GBAA5444	47530758	celA-2	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	42%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00475 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3808	16123942	livK	branched-chain amino acid-binding protei...	371	Virulence Associated Factor	Phase 2: March 2008	1USG	71.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00892 (show subtarget assignments)	0	work_stopped	No	STM3881	16767165	rbsD	high-affinity D-ribose transport protein...	139	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00099 (show subtarget assignments)	0	work_stopped	No	NT02SF1983	30041448	ynhD	putative ATP-binding component of a tran...	248	Conserved; CD; Drug target functions	Phase 1: October 2007	2D3W	99.6%	Shigella flexneri	Transport and binding proteins	Unknown substrate

IDP00474 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2512	16122733	glnH	glutamine ABC transporter periplasmic pr...	247	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	78.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00471 (show subtarget assignments)	1	purified	No	YPO0522	16120853	tbpA	thiamin transporter substrate binding su...	330	Conserved Gene / Pathway	Phase 2: March 2008	2QRY	69.7%	Yersinia pestis	Transport and binding proteins	Other

IDP00885 (show subtarget assignments)	1	purified	No	STM2206	16765536	fruF	fructose-specific PTS IIA/HPr components...	376	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	17.3%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02778 (show subtarget assignments)	1	cloned	No	CBU_0056	29540679		outer membrane protein TolC, putative [C...	616	Conserved; Drug target functions	Phase 3: June 2008	2VDD	27.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02762 (show subtarget assignments)	1	cloned	No	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01795 (show subtarget assignments)	1	expressed	No	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04109 (show subtarget assignments)	1	crystallized	No	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02749 (show subtarget assignments)	1	soluble	No	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01768 (show subtarget assignments)	1	purified	No	YPO3633	16123775		putative periplasmic binding protein [Ye...	352	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...	Phase 3: June 2008	3D02	49.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01763 (show subtarget assignments)	1	cloned	No	YPO3627	16123769	ssuB	aliphatic sulfonates transport ATP-bindi...	271	Conserved; CD; Drug target functions	Phase 3: June 2008	2IT1	35.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01758 (show subtarget assignments)	1	expressed	No	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00193 (show subtarget assignments)	1	expressed	No	YPO0966	16121269	-	putative kinase	765	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01754 (show subtarget assignments)	1	expressed	No	CBU_0803	29541397		efflux transporter, RND family, MFP subu...	351	Conserved; Drug target functions	Phase 3: June 2008	1T5E	27.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP02215 (show subtarget assignments)	1	cloned	No	Cj0077c	15791467	cdtC	cytolethal distending toxin [Campylobact...	189	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00458 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2680	16122885	celC	N,N'-diacetylchitobiose-specific PTS sys...	115	Conserved Gene / Pathway	Phase 2: March 2008	1WCR	67%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00859 (show subtarget assignments)	1	soluble	No	STM1770	16765111	chaB	cation transport regulator	76	Conserved Gene / Pathway	Phase 2: March 2008	1SG7	81.6%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00858 (show subtarget assignments)	1	purified	No	STM1342	16764693	btuD	vitamin B12-transporter ATPase	249	Conserved Gene / Pathway	Phase 2: March 2008	1L7V	80.3%	Salmonella enterica	Transport and binding proteins	Other

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP02339 (show subtarget assignments)	1	expressed	No	YPO2647	16122856	proV	glycine betaine/L-proline transport ATP-...	399	CD; Drug target functions	Phase 3: June 2008	3FVQ	25.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01734 (show subtarget assignments)	1	cloned	No	CBU_1094	29541668		efflux transporter, RND family, MFP subu...	380	Conserved; Drug target functions	Phase 3: June 2008	3FPP	23.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP00454 (show subtarget assignments)	1	expressed	No	YPO0133	16120476	feoA	ferrous iron transport protein A	75	Virulence Associated Factor	Phase 2: March 2008	2GCX	70.7%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02726 (show subtarget assignments)	1	cloned	No	GBAA4229	47529522		maltosaccharide ABC transporter, maltosa...	419	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZYK	41.5%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04377 (show subtarget assignments)	1	soluble	No	CPF_2652	110798678		putative maltose/maltodextrin ABC transp...	408	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1URG	38.7%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04378 (show subtarget assignments)	1	cloned	No	CPF_2335	110799804		extracellular solute-binding protein [Cl...	482	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP01699 (show subtarget assignments)	1	purified	No	YPO3343	16123493		extracellular solute-binding protein [Ye...	256	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3KBR	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00186 (show subtarget assignments)	1	soluble	No	YPO0695	16121016	-	putative membrane protein	140	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP01695 (show subtarget assignments)	1	expressed	No	GBAA0228	47525485		ABC transporter ATP-binding protein [Bac...	626	Conserved; Drug target functions	Phase 3: June 2008	1YQT	20.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01691 (show subtarget assignments)	1	cloned	No	CBU_1575	29542135	tolR	tolR protein [Coxiella burnetii RSA 493]...	147	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Other

IDP04366 (show subtarget assignments)	1	purified	No	CPF_1531	110800274		amino acid ABC transporter, amino acid-b...	262	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HV1	36.6%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP01687 (show subtarget assignments)	1	cloned	No	Cj0740	15792089		hypothetical protein Cj0740 [Campylobact...	54	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Amino acids, peptides and amines

IDP01683 (show subtarget assignments)	1	expressed	No	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01671 (show subtarget assignments)	1	cloned	No	YPO3012	16123191	cysA	sulfate/thiosulfate transporter subunit ...	363	Conserved; CD; Drug target functions	Phase 3: June 2008	1Z47	39.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP04370 (show subtarget assignments)	1	cloned	No	GBAA4766	47530065		iron compound ABC transporter, iron comp...	324	virulence factor; putative drug target function;	Phase 4: April 2009	3EIW	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00818 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2148	57286362		PTS system, mannitol-specific IIA compon...	144	Drug Target Function	Phase 2: March 2008	1A3A	34.7%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01667 (show subtarget assignments)	1	expressed	No	FTT1782c	56708774	yjjK	putative ABC transporter ATP-binding pro...	559	Conserved; Drug target functions	Phase 3: June 2008	1YQT	27.3%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01660 (show subtarget assignments)	1	expressed	No	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01641 (show subtarget assignments)	1	cloned	No	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	Phase 3: June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP00430 (show subtarget assignments)	1	purified	No	YPO2960	16123142	sfuC	iron(III)-transport ATP-binding protein ...	349	Virulence Associated Factor	Phase 2: March 2008	3FVQ	39.8%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00429 (show subtarget assignments)	1	purified	No	YPO2958	16123140	sfuA	iron(III)-binding periplasmic protein	339	Virulence Associated Factor	Phase 2: March 2008	1XVX	79.9%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02687 (show subtarget assignments)	1	cloned	No	lmo2580	16804618		hypothetical protein lmo2580 [Listeria m...	222	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	46.8%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP00428 (show subtarget assignments)	1	expressed	No	YPO2355	16122579	sapA	peptide transport periplasmic protein pr...	548	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	36.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02684 (show subtarget assignments)	1	cloned	No	FTT0405	56707554	lolD	lipoprotein releasing system, subunit D,...	231	Conserved; Drug target functions	Phase 3: June 2008	1F3O	44.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01614 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2581	16122794		putative sugar-binding periplasmic prote...	309	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	29.5%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01612 (show subtarget assignments)	1	cloned	No	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP00086 (show subtarget assignments)	1	in_pdb 3DR6 3DR8	No	NT01ST1973	16420114	yncA	putative acyltransferase	171	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DR6	100%	Salmonella enterica	Transport and binding proteins	Other

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01604 (show subtarget assignments)	1	crystallized	No	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	3QF4	25.6%	Coxiella burnetii	Transport and binding proteins	Other

IDP01601 (show subtarget assignments)	1	expressed	No	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02671 (show subtarget assignments)	1	selected	No	lmo0997	16803037	clpE	ATP-dependent protease [Listeria monocyt...	724	Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs	Phase 3: June 2008	1QVR	46.3%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP00421 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1331	16121613	potF	putrescine transporter subunit: periplas...	369	Virulence Associated Factor	Phase 2: March 2008	1A99	82.4%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01520 (show subtarget assignments)	1	expressed	No	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01514 (show subtarget assignments)	1	purified	No	VCA0518	15601278		fructose-specific PTS IIA/HPr components...	400	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	11.5%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02197 (show subtarget assignments)	1	cloned	No	YPO0405	16120739		putative phosphoenolpyruvate-protein pho...	852	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2KX9	24.6%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01511 (show subtarget assignments)	1	expressed	No	VC0794	15640812		hypothetical protein VC0794	139	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01509 (show subtarget assignments)	1	expressed	No	VC0549	15640571		oxaloacetate decarboxylase subunit gamma...	117	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01508 (show subtarget assignments)	1	expressed	No	VCA0127	15600898		ribose ABC transporter protein	156	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	48.1%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01506 (show subtarget assignments)	1	in_crystallization_trials	No	VCA1113	15601861		spermidine/putrescine ABC transporter, p...	343	Conserved Gene / Pathway	Phase 2: March 2008	1POT	37.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01505 (show subtarget assignments)	1	expressed	No	VCA1037	15601788		amino acid ABC transporter, ATP-binding ...	239	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	52.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01504 (show subtarget assignments)	1	expressed	No	VCA1028	15601781	lamB	maltoporin	416	Conserved Gene / Pathway	Phase 2: March 2008	1AF6	32.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01502 (show subtarget assignments)	1	expressed	No	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01501 (show subtarget assignments)	1	expressed	No	VCA0946	15601699		maltose/maltodextrin transporter ATP-bin...	373	Conserved Gene / Pathway	Phase 2: March 2008	1Q12	67.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01500 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0945	15601698	malE	maltose ABC transporter periplasmic prot...	406	Conserved Gene / Pathway	Phase 2: March 2008	3JYR	65%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00760 (show subtarget assignments)	1	soluble	No	SACOL0192	57285394		maltose ABC transporter, ATP-binding pro...	365	Drug Target Function	Phase 2: March 2008	2D62	53.5%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01498 (show subtarget assignments)	1	expressed	No	VCA0862	15601617		long-chain fatty acid transport protein ...	412	Conserved Gene / Pathway	Phase 2: March 2008	1T16	39.2%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01491 (show subtarget assignments)	1	soluble	No	VCA0603	15601361		ABC transporter, periplasmic substrate-b...	339	Conserved Gene / Pathway	Phase 2: March 2008	1Y4T	18.3%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00752 (show subtarget assignments)	1	purified	No	SACOL2211	57284992		ABC transporter, ATP-binding protein	269	Drug Target Function	Phase 2: March 2008	3GFO	37.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01485 (show subtarget assignments)	1	soluble	No	VCA0220	15600989		hemolysin secretion protein HylB	548	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	16.4%	Vibrio cholerae	Transport and binding proteins	Other

IDP01484 (show subtarget assignments)	1	in_pdb 4EH1	No	VCA0183	15600953		nitric oxide dioxygenase	394	Conserved Gene / Pathway	Phase 2: March 2008	4EH1	61.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01481 (show subtarget assignments)	1	expressed	No	VCA0130	15600901		D-ribose transporter subunit RbsB	294	Conserved Gene / Pathway	Phase 2: March 2008	1DBP	65.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01479 (show subtarget assignments)	1	expressed	No	VCA0064	15600835		TonB system receptor, putative	713	Conserved Gene / Pathway	Phase 2: March 2008	1NQF	22.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02650 (show subtarget assignments)	1	expressed	No	YPO3962	16124090		sugar-binding transport protein [Yersini...	314	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	34.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01470 (show subtarget assignments)	1	purified	No	VC2608	15642603		ABC transporter, ATP-binding protein	664	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	23.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01468 (show subtarget assignments)	1	purified	No	VC2553	15642548		ABC transporter, ATP-binding protein, au...	238	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	32.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01465 (show subtarget assignments)	1	purified	No	VC2528	15642523		ABC transporter, ATP-binding protein	241	Conserved Gene / Pathway	Phase 2: March 2008	1JI0	33.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01464 (show subtarget assignments)	1	soluble	No	VC2520	15642516		ABC transporter, ATP-binding protein	267	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	34.5%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP02305 (show subtarget assignments)	1	purified	No	YPO1310	16121592		putative periplasmic substrate-binding t...	381	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00738 (show subtarget assignments)	1	cloned	No	SACOL0994	57284368	oppF	oligopeptide ABC transporter, ATP-bindin...	313	Drug Target Function	Phase 2: March 2008	2YZ2	27.2%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00405 (show subtarget assignments)	1	purified	No	YPO4025	16124148		putative iron ABC transporter, ATP-bindi...	252	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.3%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00737 (show subtarget assignments)	1	expressed	No	SACOL0993	57284367	oppD	oligopeptide ABC transporter, ATP-bindin...	360	Drug Target Function	Phase 2: March 2008	1B0U	25%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP02641 (show subtarget assignments)	1	purified	No	GBAA0640	47525919		amino acid ABC transporter amino acid-bi...	276	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V25	33.3%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01451 (show subtarget assignments)	1	purified	No	VC2305	15642303		outer membrane protein OmpK	296	Conserved Gene / Pathway	Phase 2: March 2008	1TLW	26%	Vibrio cholerae	Transport and binding proteins	Nucleosides, purines and pyrimidines

IDP04270 (show subtarget assignments)	1	cloned	No	CPF_2226	110799081	potD	spermidine/putrescine ABC transporter, s...	360	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EQB	40.3%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP02198 (show subtarget assignments)	1	cloned	No	YPO1273	16121558		putative substrate-binding transport pro...	602	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1XOC	21.6%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00732 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2473	57286467		peptide ABC transporter, ATP-binding pro...	271	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	31.7%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01444 (show subtarget assignments)	1	soluble	No	VC2081	15642081		zinc ABC transporter, periplasmic zinc-b...	297	Conserved Gene / Pathway	Phase 2: March 2008	2OGW	44.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00731 (show subtarget assignments)	1	purified	No	SACOL2462	57286457		ABC transporter, ATP-binding protein	220	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00897
(show subtarget assignments)

1

expressed

No

STM0771

16764135

putative ABC-type cobalamin/Fe3+-siderop...

258

Conserved Gene / Pathway

Phase 2: March 2008

2ONK

32.2%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP02347
(show subtarget assignments)

1

soluble

No

YPO1783

16122037

ftnA

ferritin [Yersinia pestis CO92]

169

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QZ3

68.6%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01818
(show subtarget assignments)

1

soluble

No

GBAA5444

47530758

celA-2

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

42%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00475
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3808

16123942

livK

branched-chain amino acid-binding protei...

371

Virulence Associated Factor

Phase 2: March 2008

1USG

71.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00892
(show subtarget assignments)

0

work_stopped

No

STM3881

16767165

rbsD

high-affinity D-ribose transport protein...

139

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00099
(show subtarget assignments)

0

work_stopped

No

NT02SF1983

30041448

ynhD

putative ATP-binding component of a tran...

248

Conserved; CD; Drug target functions

Phase 1: October 2007

2D3W

99.6%

Shigella flexneri

Transport and binding proteins

Unknown substrate

IDP00474
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2512

16122733

glnH

glutamine ABC transporter periplasmic pr...

247

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

78.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00471
(show subtarget assignments)

1

purified

No

YPO0522

16120853

tbpA

thiamin transporter substrate binding su...

330

Conserved Gene / Pathway

Phase 2: March 2008

2QRY

69.7%

Yersinia pestis

Transport and binding proteins

Other

IDP00885
(show subtarget assignments)

1

purified

No

STM2206

16765536

fruF

fructose-specific PTS IIA/HPr components...

376

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

17.3%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02778
(show subtarget assignments)

1

cloned

No

CBU_0056

29540679

outer membrane protein TolC, putative [C...

616

Conserved; Drug target functions

Phase 3: June 2008

2VDD

27.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02762
(show subtarget assignments)

1

cloned

No

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01795
(show subtarget assignments)

1

expressed

No

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04109
(show subtarget assignments)

1

crystallized

No

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02749
(show subtarget assignments)

1

soluble

No

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01768
(show subtarget assignments)

1

purified

No

YPO3633

16123775

putative periplasmic binding protein [Ye...

352

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...

Phase 3: June 2008

3D02

49.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01763
(show subtarget assignments)

1

cloned

No

YPO3627

16123769

ssuB

aliphatic sulfonates transport ATP-bindi...

271

Conserved; CD; Drug target functions

Phase 3: June 2008

2IT1

35.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01758
(show subtarget assignments)

1

expressed

No

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00193
(show subtarget assignments)

1

expressed

No

YPO0966

16121269

-

putative kinase

765

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01754
(show subtarget assignments)

1

expressed

No

CBU_0803

29541397

efflux transporter, RND family, MFP subu...

351

Conserved; Drug target functions

Phase 3: June 2008

1T5E

27.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP02215
(show subtarget assignments)

1

cloned

No

Cj0077c

15791467

cdtC

cytolethal distending toxin [Campylobact...

189

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00458
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2680

16122885

celC

N,N'-diacetylchitobiose-specific PTS sys...

115

Conserved Gene / Pathway

Phase 2: March 2008

1WCR

67%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00859
(show subtarget assignments)

1

soluble

No

STM1770

16765111

chaB

cation transport regulator

76

Conserved Gene / Pathway

Phase 2: March 2008

1SG7

81.6%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00858
(show subtarget assignments)

1

purified

No

STM1342

16764693

btuD

vitamin B12-transporter ATPase

249

Conserved Gene / Pathway

Phase 2: March 2008

1L7V

80.3%

Salmonella enterica

Transport and binding proteins

Other

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP02339
(show subtarget assignments)

1

expressed

No

YPO2647

16122856

proV

glycine betaine/L-proline transport ATP-...

399

CD; Drug target functions

Phase 3: June 2008

3FVQ

25.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01734
(show subtarget assignments)

1

cloned

No

CBU_1094

29541668

efflux transporter, RND family, MFP subu...

380

Conserved; Drug target functions

Phase 3: June 2008

3FPP

23.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP00454
(show subtarget assignments)

1

expressed

No

YPO0133

16120476

feoA

ferrous iron transport protein A

75

Virulence Associated Factor

Phase 2: March 2008

2GCX

70.7%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02726
(show subtarget assignments)

1

cloned

No

GBAA4229

47529522

maltosaccharide ABC transporter, maltosa...

419

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZYK

41.5%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04377
(show subtarget assignments)

1

soluble

No

CPF_2652

110798678

putative maltose/maltodextrin ABC transp...

408

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1URG

38.7%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04378
(show subtarget assignments)

1

cloned

No

CPF_2335

110799804

extracellular solute-binding protein [Cl...

482

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP01699
(show subtarget assignments)

1

purified

No

YPO3343

16123493

extracellular solute-binding protein [Ye...

256

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3KBR

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00186
(show subtarget assignments)

1

soluble

No

YPO0695

16121016

-

putative membrane protein

140

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP01695
(show subtarget assignments)

1

expressed

No

GBAA0228

47525485

ABC transporter ATP-binding protein [Bac...

626

Conserved; Drug target functions

Phase 3: June 2008

1YQT

20.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01691
(show subtarget assignments)

1

cloned

No

CBU_1575

29542135

tolR

tolR protein [Coxiella burnetii RSA 493]...

147

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Other

IDP04366
(show subtarget assignments)

1

purified

No

CPF_1531

110800274

amino acid ABC transporter, amino acid-b...

262

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HV1

36.6%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP01687
(show subtarget assignments)

1

cloned

No

Cj0740

15792089

hypothetical protein Cj0740 [Campylobact...

54

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Amino acids, peptides and amines

IDP01683
(show subtarget assignments)

1

expressed

No

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01671
(show subtarget assignments)

1

cloned

No

YPO3012

16123191

cysA

sulfate/thiosulfate transporter subunit ...

363

Conserved; CD; Drug target functions

Phase 3: June 2008

1Z47

39.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP04370
(show subtarget assignments)

1

cloned

No

GBAA4766

47530065

iron compound ABC transporter, iron comp...

324

virulence factor; putative drug target function;

Phase 4: April 2009

3EIW

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00818
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2148

57286362

PTS system, mannitol-specific IIA compon...

144

Drug Target Function

Phase 2: March 2008

1A3A

34.7%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01667
(show subtarget assignments)

1

expressed

No

FTT1782c

56708774

yjjK

putative ABC transporter ATP-binding pro...

559

Conserved; Drug target functions

Phase 3: June 2008

1YQT

27.3%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01660
(show subtarget assignments)

1

expressed

No

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01641
(show subtarget assignments)

1

cloned

No

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

Phase 3: June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP00430
(show subtarget assignments)

1

purified

No

YPO2960

16123142

sfuC

iron(III)-transport ATP-binding protein ...

349

Virulence Associated Factor

Phase 2: March 2008

3FVQ

39.8%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00429
(show subtarget assignments)

1

purified

No

YPO2958

16123140

sfuA

iron(III)-binding periplasmic protein

339

Virulence Associated Factor

Phase 2: March 2008

1XVX

79.9%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02687
(show subtarget assignments)

1

cloned

No

lmo2580

16804618

hypothetical protein lmo2580 [Listeria m...

222

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

46.8%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP00428
(show subtarget assignments)

1

expressed

No

YPO2355

16122579

sapA

peptide transport periplasmic protein pr...

548

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

36.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02684
(show subtarget assignments)

1

cloned

No

FTT0405

56707554

lolD

lipoprotein releasing system, subunit D,...

231

Conserved; Drug target functions

Phase 3: June 2008

1F3O

44.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01614
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2581

16122794

putative sugar-binding periplasmic prote...

309

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

29.5%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01612
(show subtarget assignments)

1

cloned

No

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP00086
(show subtarget assignments)

1

in_pdb
3DR6
3DR8

No

NT01ST1973

16420114

yncA

putative acyltransferase

171

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DR6

100%

Salmonella enterica

Transport and binding proteins

Other

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01604
(show subtarget assignments)

1

crystallized

No

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

3QF4

25.6%

Coxiella burnetii

Transport and binding proteins

Other

IDP01601
(show subtarget assignments)

1

expressed

No

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02671
(show subtarget assignments)

1

selected

No

lmo0997

16803037

clpE

ATP-dependent protease [Listeria monocyt...

724

Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs

Phase 3: June 2008

1QVR

46.3%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP00421
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1331

16121613

potF

putrescine transporter subunit: periplas...

369

Virulence Associated Factor

Phase 2: March 2008

1A99

82.4%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01520
(show subtarget assignments)

1

expressed

No

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01514
(show subtarget assignments)

1

purified

No

VCA0518

15601278

fructose-specific PTS IIA/HPr components...

400

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

11.5%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02197
(show subtarget assignments)

1

cloned

No

YPO0405

16120739

putative phosphoenolpyruvate-protein pho...

852

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2KX9

24.6%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01511
(show subtarget assignments)

1

expressed

No

VC0794

15640812

hypothetical protein VC0794

139

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01509
(show subtarget assignments)

1

expressed

No

VC0549

15640571

oxaloacetate decarboxylase subunit gamma...

117

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01508
(show subtarget assignments)

1

expressed

No

VCA0127

15600898

ribose ABC transporter protein

156

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

48.1%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01506
(show subtarget assignments)

1

in_crystallization_trials

No

VCA1113

15601861

spermidine/putrescine ABC transporter, p...

343

Conserved Gene / Pathway

Phase 2: March 2008

1POT

37.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01505
(show subtarget assignments)

1

expressed

No

VCA1037

15601788

amino acid ABC transporter, ATP-binding ...

239

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

52.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01504
(show subtarget assignments)

1

expressed

No

VCA1028

15601781

lamB

maltoporin

416

Conserved Gene / Pathway

Phase 2: March 2008

1AF6

32.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01502
(show subtarget assignments)

1

expressed

No

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01501
(show subtarget assignments)

1

expressed

No

VCA0946

15601699

maltose/maltodextrin transporter ATP-bin...

373

Conserved Gene / Pathway

Phase 2: March 2008

1Q12

67.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01500
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0945

15601698

malE

maltose ABC transporter periplasmic prot...

406

Conserved Gene / Pathway

Phase 2: March 2008

3JYR

65%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00760
(show subtarget assignments)

1

soluble

No

SACOL0192

57285394

maltose ABC transporter, ATP-binding pro...

365

Drug Target Function

Phase 2: March 2008

2D62

53.5%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01498
(show subtarget assignments)

1

expressed

No

VCA0862

15601617

long-chain fatty acid transport protein ...

412

Conserved Gene / Pathway

Phase 2: March 2008

1T16

39.2%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01491
(show subtarget assignments)

1

soluble

No

VCA0603

15601361

ABC transporter, periplasmic substrate-b...

339

Conserved Gene / Pathway

Phase 2: March 2008

1Y4T

18.3%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00752
(show subtarget assignments)

1

purified

No

SACOL2211

57284992

ABC transporter, ATP-binding protein

269

Drug Target Function

Phase 2: March 2008

3GFO

37.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01485
(show subtarget assignments)

1

soluble

No

VCA0220

15600989

hemolysin secretion protein HylB

548

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

16.4%

Vibrio cholerae

Transport and binding proteins

Other

IDP01484
(show subtarget assignments)

1

in_pdb
4EH1

No

VCA0183

15600953

nitric oxide dioxygenase

394

Conserved Gene / Pathway

Phase 2: March 2008

4EH1

61.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01481
(show subtarget assignments)

1

expressed

No

VCA0130

15600901

D-ribose transporter subunit RbsB

294

Conserved Gene / Pathway

Phase 2: March 2008

1DBP

65.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01479
(show subtarget assignments)

1

expressed

No

VCA0064

15600835

TonB system receptor, putative

713

Conserved Gene / Pathway

Phase 2: March 2008

1NQF

22.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02650
(show subtarget assignments)

1

expressed

No

YPO3962

16124090

sugar-binding transport protein [Yersini...

314

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

34.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01470
(show subtarget assignments)

1

purified

No

VC2608

15642603

ABC transporter, ATP-binding protein

664

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

23.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01468
(show subtarget assignments)

1

purified

No

VC2553

15642548

ABC transporter, ATP-binding protein, au...

238

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

32.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01465
(show subtarget assignments)

1

purified

No

VC2528

15642523

ABC transporter, ATP-binding protein

241

Conserved Gene / Pathway

Phase 2: March 2008

1JI0

33.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01464
(show subtarget assignments)

1

soluble

No

VC2520

15642516

ABC transporter, ATP-binding protein

267

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

34.5%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP02305
(show subtarget assignments)

1

purified

No

YPO1310

16121592

putative periplasmic substrate-binding t...

381

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00738
(show subtarget assignments)

1

cloned

No

SACOL0994

57284368

oppF

oligopeptide ABC transporter, ATP-bindin...

313

Drug Target Function

Phase 2: March 2008

2YZ2

27.2%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00405
(show subtarget assignments)

1

purified

No

YPO4025

16124148

putative iron ABC transporter, ATP-bindi...

252

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.3%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00737
(show subtarget assignments)

1

expressed

No

SACOL0993

57284367

oppD

oligopeptide ABC transporter, ATP-bindin...

360

Drug Target Function

Phase 2: March 2008

1B0U

25%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP02641
(show subtarget assignments)

1

purified

No

GBAA0640

47525919

amino acid ABC transporter amino acid-bi...

276

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V25

33.3%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01451
(show subtarget assignments)

1

purified

No

VC2305

15642303

outer membrane protein OmpK

296

Conserved Gene / Pathway

Phase 2: March 2008

1TLW

26%

Vibrio cholerae

Transport and binding proteins

Nucleosides, purines and pyrimidines

IDP04270
(show subtarget assignments)

1

cloned

No

CPF_2226

110799081

potD

spermidine/putrescine ABC transporter, s...

360

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EQB

40.3%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP02198
(show subtarget assignments)

1

cloned

No

YPO1273

16121558

putative substrate-binding transport pro...

602

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1XOC

21.6%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00732
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2473

57286467

peptide ABC transporter, ATP-binding pro...

271

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

31.7%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01444
(show subtarget assignments)

1

soluble

No

VC2081

15642081

zinc ABC transporter, periplasmic zinc-b...

297

Conserved Gene / Pathway

Phase 2: March 2008

2OGW

44.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00731
(show subtarget assignments)

1

purified

No

SACOL2462

57286457

ABC transporter, ATP-binding protein

220

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

Targets