Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02030 (show subtarget assignments)	1	expressed	No	CBU_1255	29541825		geranyltranstransferase, putative [Coxie...	267	Conserved; Drug target functions	Phase 3: June 2008	3TS7	40.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02031 (show subtarget assignments)	1	cloned	No	lmo2504	16804542		hypothetical protein lmo2504 [Listeria m...	436	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2GU1	17.2%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01001 (show subtarget assignments)	1	soluble	No	STM2405	16765731		indolepyruvate decarboxylase	550	Conserved Gene / Pathway	Phase 2: March 2008	1OVM	66.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP02033 (show subtarget assignments)	1	cloned	No	Cj1135	15792460		glycosyltransferase [Campylobacter jejun...	515	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2Z86	14%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02034 (show subtarget assignments)	1	cloned	No	lmo0059	16802107		hypothetical protein lmo0059 [Listeria m...	83	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008	2BPS	27.7%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP01002 (show subtarget assignments)	1	in_pdb 3ERP	Yes	STM2406	16765732		putative oxidoreductase	332	Essential Gene	Phase 2: March 2008	3ERP	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP02036 (show subtarget assignments)	1	cloned	No	GBAA1500	47526774		M23/37 family peptidase [Bacillus anthra...	204	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	3SLU	23.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00028 (show subtarget assignments)	1	purified	No	BA_0401	30253936		tellurium resistance protein	194	Virulence	Phase 1: October 2007	2KXT	57.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02038 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2475	16804513		hypothetical protein lmo2475 [Listeria m...	576	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	2Z0F	29.3%	Listeria monocytogenes	Energy metabolism	Sugars

IDP02039 (show subtarget assignments)	1	expressed	No	YPO1198	16121491		putative ABC transport ATP-binding subun...	312	Conserved; CD; Drug target functions	Phase 3: June 2008	1V43	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP04706 (show subtarget assignments)	1	expressed	No	BAS0105	49183139		30S ribosomal protein S12 [Bacillus anth...	140	Proposed to be essential proteins	Phase 4: April 2009	2F4V	71.4%	Bacillus anthracis

IDP04511 (show subtarget assignments)	1	cloned	No	CPF_2297	110798696		stage II sporulation protein P [Clostrid...	361	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01006 (show subtarget assignments)	1	soluble	No	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02043 (show subtarget assignments)	1	expressed	No	Cj1145c	15792470		hypothetical protein Cj1145c [Campylobac...	105	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02749 (show subtarget assignments)	1	soluble	No	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP02045 (show subtarget assignments)	1	cloned	No	FTT0749c	56707864		hypothetical protein FTT0749c [Francisel...	328	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3AIM	25.6%	Francisella tularensis	Central intermediary metabolism	Other

IDP04192 (show subtarget assignments)	1	cloned	No	CPF_0671	110799768		phosphoribosylformylglycinamidine syntha...	1266	conserved gene; putative drug target function;	Phase 4: April 2009	3AC6	15.2%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04017 (show subtarget assignments)	1	cloned	No	CPF_1035	110799411		putative lipoprotein [Clostridium perfri...	309	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP02048 (show subtarget assignments)	1	expressed	No	STM3737	16767022		putative Zn-dependent hydrolase [Salmone...	293	Conserved; Drug target functions	Phase 3: June 2008	1JT1	30.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP02049 (show subtarget assignments)	1	expressed	No	STM3122	16766422		putative arylsulfatase [Salmonella typhi...	579	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1HDH	36.1%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP02138 (show subtarget assignments)	1	expressed	No	Cj0580c	15791940		coproporphyrinogen III oxidase [Campylob...	355	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	22.5%	Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP02051 (show subtarget assignments)	1	cloned	No	STM4141	16767399		putative cytoplasmic protein [Salmonella...	57	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02052 (show subtarget assignments)	1	cloned	No	YPO2924	16123111		hypothetical protein YPO2924 [Yersinia p...	215	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP02053 (show subtarget assignments)	1	soluble	No	YPO3699	16123838		hypothetical protein YPO3699 [Yersinia p...	158	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3OD9	32.9%	Yersinia pestis	Cell envelope	Other

IDP04152 (show subtarget assignments)	1	cloned	No	YPO3919	218930919		HlyD family secretion protein [Yersinia ...	442	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02598 (show subtarget assignments)	1	cloned	No	Cj1429c	15792747		hypothetical protein Cj1429c [Campylobac...	308	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02056 (show subtarget assignments)	1	expressed	No	CBU_0934	29541521		ABC transporter, ATP-binding protein [Co...	304	Conserved; Drug target functions	Phase 3: June 2008	1VPL	27.6%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04305 (show subtarget assignments)	1	cloned	No	CPF_2386	110798631		ribonuclease [Clostridium perfringens AT...	480	conserved gene; putative drug target function;	Phase 4: April 2009	2BX2	27.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04506 (show subtarget assignments)	1	cloned	No	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP02059 (show subtarget assignments)	1	expressed	No	YPO1353	16121633		chorismate mutase [Yersinia pestis CO92]...	186	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2GBB	83.9%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP02060 (show subtarget assignments)	1	expressed	No	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04079 (show subtarget assignments)	1	purified	No	BAS0100	49183134		50S ribosomal protein L7/L12 [Bacillus a...	119	Proposed to be essential proteins	Phase 4: April 2009	1DD3	63.3%	Bacillus anthracis

IDP04371 (show subtarget assignments)	1	expressed	No	GBAA4776	47778322		sensor histidine kinase [Bacillus anthra...	311	putative drug target function;	Phase 4: April 2009	2C2A	19.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04375 (show subtarget assignments)	1	expressed	No	VCA0211	15600980		sensory box sensor histidine kinase [Vib...	648	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3D36	9.7%	Vibrio cholerae	Regulatory functions	Other

IDP02064 (show subtarget assignments)	1	cloned	No	YPO3878	16124011		putative fimbrial chaperone [Yersinia pe...	243	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.5%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02065 (show subtarget assignments)	1	in_pdb 3IAC	No	STM3137	16766437		glucuronate isomerase [Salmonella typhim...	470	Conserved; Drug target functions	Phase 3: June 2008	3IAC	100%	Salmonella enterica	Energy metabolism	Sugars

IDP02262 (show subtarget assignments)	1	purified	No	FTT1532	56708566		hypothetical protein FTT1532 [Francisell...	162	Drug Target	Phase 3: June 2008	3NWZ	16%	Francisella tularensis	Unknown function	General

IDP02067 (show subtarget assignments)	1	purified	No	FTT0825c	56707936		hypothetical protein FTT0825c [Francisel...	111	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP00057 (show subtarget assignments)	1	soluble	No	BA_3900	30258414		lantibiotic biosynthesis DNA-binding res...	220	Virulence	Phase 1: October 2007	2GWR	34.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02369 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3204	47778134		short chain dehydrogenase [Bacillus anth...	257	Conserved; Essential;	Phase 3: June 2008	3ICC	61.9%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02070 (show subtarget assignments)	1	expressed	No	CBU_1809	29542365		ABC transporter, ATP-binding protein [Co...	221	Conserved; Drug target functions	Phase 3: June 2008	1F3O	49.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02233 (show subtarget assignments)	1	cloned	No	lmo0056	16802104		hypothetical protein lmo0056 [Listeria m...	97	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008	2VRZ	50.5%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP02072 (show subtarget assignments)	1	soluble	No	FTT0554	56707684		hypothetical protein FTT0554 [Francisell...	90	Drug Target	Phase 3: June 2008	4ADZ	35.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP02073 (show subtarget assignments)	1	expressed	No	CBU_0418	29541027		4-amino-4-deoxychorismate lyase, putativ...	281	Conserved; Drug target functions	Phase 3: June 2008	3LUL	28.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02278 (show subtarget assignments)	1	expressed	No	Cj0045c	15791444		putative iron-binding protein [Campyloba...	240	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2AWC	13.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04021 (show subtarget assignments)	1	expressed	No	BAS3695	49186694		30S ribosomal protein S16 [Bacillus anth...	90	Proposed to be essential proteins	Phase 4: April 2009	1EMW	42.2%	Bacillus anthracis

IDP02076 (show subtarget assignments)	1	soluble	No	STM3216	16766515		putative methyl-accepting chemotaxis pro...	521	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	28.6%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP02077 (show subtarget assignments)	1	soluble	No	YPO0271	16120610		putative type III secretion apparatus pr...	97	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02078 (show subtarget assignments)	1	expressed	No	YPO0268	16120606		type III secretion system apparatus prot...	133	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02079 (show subtarget assignments)	1	expressed	No	Cj0173c	15791560		iron ABC transporter, ATP binding subuni...	302	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2D62	35.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04705 (show subtarget assignments)	1	cloned	No	YPO0499	115346308		hypothetical protein [Yersinia pestis CO...	337	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP02081 (show subtarget assignments)	1	cloned	No	Cj1340c	15792663		hypothetical protein Cj1340c [Campylobac...	605	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01026 (show subtarget assignments)	1	cloned	No	STM1267	16764618		putative cytoplasmic protein	82	Conserved Gene / Pathway	Phase 2: March 2008	2OXL	32.9%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP02440 (show subtarget assignments)	1	cloned	No	lmo0331	16802376		hypothetical protein lmo0331 [Listeria m...	633	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	3BZ5	28.4%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP00251 (show subtarget assignments)	1	cloned	No	MVEVgp1	9633623		Murray Valley encephalitis Envelope prot...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3P54	78.1%	Murray Valley

IDP04662 (show subtarget assignments)	1	cloned	No	GBAA0650	47525929		sensor histidine kinase [Bacillus anthra...	463	putative drug target function;	Phase 4: April 2009	2C2A	17.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP05265 (show subtarget assignments)	1	purified	No	CD3543	126701167		putative nicotinate phosphribosyltransfe...	476	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2F7F	43.3%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04590 (show subtarget assignments)	1	expressed	No	BAS0136	49183170		30S ribosomal protein S11 [Bacillus anth...	129	Proposed to be essential proteins	Phase 4: April 2009	1VS5	65.9%	Bacillus anthracis

IDP00058 (show subtarget assignments)	1	soluble	No	BA_3903	30258417		bacteriocin ABC transporter, ATP-binding...	234	Virulence	Phase 1: October 2007	1OXS	32.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02532 (show subtarget assignments)	1	cloned	No	GBAA1879	47527172		M23/37 family peptidase [Bacillus anthra...	262	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04486 (show subtarget assignments)	1	cloned	No	YPO3597	115349218		conserved hypothetical protein [Yersinia...	448	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP02420 (show subtarget assignments)	1	expressed	No	YPO1501	16121774		putative esterase [Yersinia pestis CO92]...	280	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	3I6Y	58.9%	Yersinia pestis	Central intermediary metabolism	Other

IDP02092 (show subtarget assignments)	1	cloned	No	YPO0259	16120596		putative type III secretion apparatus [Y...	73	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00252 (show subtarget assignments)	1	in_crystallization_trials	No		130516		St. Louis encephalitis virus Envelope pr...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	2I69	70.5%	St. Louis

IDP02094 (show subtarget assignments)	1	cloned	No	STM3598	16766884		putative L-asparaginase [Salmonella typh...	347	Conserved; Drug target functions	Phase 3: June 2008	1ZCF	68.9%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP02174 (show subtarget assignments)	1	cloned	No	YPO3031	16123208		putative acetyltransferase [Yersinia pes...	141	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2PDO	78%	Yersinia pestis	Central intermediary metabolism	Other

IDP04668 (show subtarget assignments)	1	cloned	No	GBAA1327	47526592		phaP protein [Bacillus anthracis str. 'A...	174	conserved gene; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04691 (show subtarget assignments)	1	soluble	No	GBAA5067	47530367		sensory box histidine kinase [Bacillus a...	617	putative drug target function;	Phase 4: April 2009	3A0R	10.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04542 (show subtarget assignments)	1	expressed	No	YPO2000	218929110		putative two-component system sensor pro...	463	putative drug target function;	Phase 4: April 2009	3JZ3	13.2%	Yersinia pestis	Regulatory functions	Other

IDP02099 (show subtarget assignments)	1	cloned	No	FTT0972	56708065		ABC transporter, ATP-binding protein [Fr...	249	Conserved; Drug target functions	Phase 3: June 2008	2D3W	57.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00253 (show subtarget assignments)	1	in_crystallization_trials	No	YFVgp1	9627245		Yellow fever virus Envelope protein	399	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1P58	43.8%	Yellow fever

IDP02163 (show subtarget assignments)	1	cloned	No	GBAA3914	47529205		phosphodiesterase [Bacillus anthracis st...	520	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	General

IDP02329 (show subtarget assignments)	1	in_pdb 3KQF	Yes	GBAA2551	47527840		enoyl-CoA hydratase [Bacillus anthracis ...	262	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3KQF	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04181 (show subtarget assignments)	1	crystallized	No	VCA0197	9657589		GMP reductase [Vibrio cholerae O1 biovar...	347	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2A7R	63.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02104 (show subtarget assignments)	1	soluble	No	YPO1074	16121375		D,D-heptose 1,7-bisphosphate phosphatase...	188	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2GMW	80.9%	Yersinia pestis	Unknown function	General

IDP02105 (show subtarget assignments)	1	cloned	No	lmo0063	16802111		hypothetical protein lmo0063 [Listeria m...	99	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008			Listeria monocytogenes	Hypothetical proteins	Conserved

IDP04071 (show subtarget assignments)	1	cloned	No	BAS0129	49183163		50S ribosomal protein L15 [Bacillus anth...	146	Proposed to be essential proteins	Phase 4: April 2009	1VSA	51.4%	Bacillus anthracis

IDP02107 (show subtarget assignments)	1	cloned	No	GBAA2607	47778067		lipase, putative [Bacillus anthracis str...	400	Conserved; Involved in sporulation; Vaccine Target; Drug target functions	Phase 3: June 2008	2DSN	48%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP00254 (show subtarget assignments)	1	in_pdb 3P54	Yes		13272205		Japanese encephalitis virus Envelope pro...	406	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3P54	98.3%	Japanese encephalitis

IDP02109 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1186	16121481		hypothetical protein YPO1186 [Yersinia p...	157	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Hypothetical proteins	Conserved

IDP02110 (show subtarget assignments)	1	expressed	No	STM3820	16767105		putative cytochrome c peroxidase [Salmon...	466	Conserved; Drug target functions	Phase 3: June 2008	1IQC	29.4%	Salmonella enterica	Cellular processes	Detoxification

IDP02325 (show subtarget assignments)	1	in_pdb 3IMF	No	GBAA4204	47778260		short chain dehydrogenase [Bacillus anth...	254	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3IMF	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP04091 (show subtarget assignments)	1	cloned	No	CPF_1278	110799680		putative lipoprotein [Clostridium perfri...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04404 (show subtarget assignments)	1	cloned	No	VC2602	15642597		adenylosuccinate synthetase [Vibrio chol...	432	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KJX	75.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04028 (show subtarget assignments)	1	purified	No	BAS0109	49183143		30S ribosomal protein S10 [Bacillus anth...	102	Proposed to be essential proteins	Phase 4: April 2009	1P6G	61.8%	Bacillus anthracis

IDP02115 (show subtarget assignments)	1	purified	No	FTT0900	56708001		hypothetical protein FTT0900 [Francisell...	123	Drug Target	Community Requests	2GM2	22.8%	Francisella tularensis	Cell envelope	Other

IDP00059 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4013	30258522		fibronectin/fibrinogen-binding protein, ...	569	Virulence	Phase 1: October 2007	3DOA	22.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP04419 (show subtarget assignments)	1	soluble	No	GBAA2861	47528156		sensor histidine kinase SrrB, putative [...	458	putative drug target function;	Phase 4: April 2009	2C2A	18.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02348 (show subtarget assignments)	1	soluble	No	GBAA2803	47528096		S-layer protein, putative [Bacillus anth...	461	Drug target motif; Drug target functions	Phase 3: June 2008	3PYW	12.4%	Bacillus anthracis	Cell envelope	Surface structures

IDP02269 (show subtarget assignments)	1	cloned	No	Cj0608	15791968		outer membrane efflux protein [Campyloba...	456	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	3PIK	23.7%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP02120 (show subtarget assignments)	1	expressed	No	YPO0027	16120380		phosphatase [Yersinia pestis CO92]	196	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2B0C	66.8%	Yersinia pestis	Unknown function	General

IDP02121 (show subtarget assignments)	1	cloned	No	FTT0360	56707511		Short-chain dehydrogenase/reductase [Fra...	274	Drug Target	Phase 3: June 2008	1FDW	27.7%	Francisella tularensis	Central intermediary metabolism	Other

IDP01046 (show subtarget assignments)	1	expressed	No	STM3138	16766438		putative methyl-accepting chemotaxis pro...	352	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	16.8%	Salmonella enterica	Cellular processes	Other

IDP02123 (show subtarget assignments)	1	purified	No	YPO1255	16121542		hypothetical protein YPO1255 [Yersinia p...	120	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Hypothetical proteins	Conserved

IDP01047 (show subtarget assignments)	1	cloned	No	STM3152	16766452		putative methyl-accepting chemotaxis pro...	547	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	34.7%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP02274 (show subtarget assignments)	1	in_pdb 3IJ5	Yes	YPO3578	16123722		3-deoxy-D-manno-octulosonate 8-phosphate...	187	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3IJ5	100%	Yersinia pestis	Hypothetical proteins	Conserved

IDP02126 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1221	56708283		hypothetical protein FTT1221 [Francisell...	88	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelopeRegulatory functions,Unknown function	Biosynthesis and degradation of murein sacculus and peptidoglycanOther,General

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP90162 (show subtarget assignments)	8	purified	No	CD1833	123174272		3-dehydroquinate synthase	354	Potential drug target. Shikimate pathway enzyme	Community Requests	3OKF	40.1%	Clostridium difficile

IDP90161 (show subtarget assignments)	8	purified	No	CD1835	123174273		Chorismate synthase (5-enolpyruvylshikim...	359	Potential drug target. Shikimate pathway enzyme	Community Requests	1UM0	38.7%	Clostridium difficile

IDP02030
(show subtarget assignments)

1

expressed

No

CBU_1255

29541825

geranyltranstransferase, putative [Coxie...

267

Conserved; Drug target functions

Phase 3: June 2008

3TS7

40.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02031
(show subtarget assignments)

1

cloned

No

lmo2504

16804542

hypothetical protein lmo2504 [Listeria m...

436

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2GU1

17.2%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01001
(show subtarget assignments)

1

soluble

No

STM2405

16765731

indolepyruvate decarboxylase

550

Conserved Gene / Pathway

Phase 2: March 2008

1OVM

66.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP02033
(show subtarget assignments)

1

cloned

No

Cj1135

15792460

glycosyltransferase [Campylobacter jejun...

515

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2Z86

14%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02034
(show subtarget assignments)

1

cloned

No

lmo0059

16802107

hypothetical protein lmo0059 [Listeria m...

83

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

2BPS

27.7%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP01002
(show subtarget assignments)

1

in_pdb
3ERP

Yes

STM2406

16765732

putative oxidoreductase

332

Essential Gene

Phase 2: March 2008

3ERP

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP02036
(show subtarget assignments)

1

cloned

No

GBAA1500

47526774

M23/37 family peptidase [Bacillus anthra...

204

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

3SLU

23.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00028
(show subtarget assignments)

1

purified

No

BA_0401

30253936

tellurium resistance protein

194

Virulence

Phase 1: October 2007

2KXT

57.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02038
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2475

16804513

hypothetical protein lmo2475 [Listeria m...

576

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

2Z0F

29.3%

Listeria monocytogenes

Energy metabolism

Sugars

IDP02039
(show subtarget assignments)

1

expressed

No

YPO1198

16121491

putative ABC transport ATP-binding subun...

312

Conserved; CD; Drug target functions

Phase 3: June 2008

1V43

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP04706
(show subtarget assignments)

1

expressed

No

BAS0105

49183139

30S ribosomal protein S12 [Bacillus anth...

140

Proposed to be essential proteins

Phase 4: April 2009

2F4V

71.4%

Bacillus anthracis

IDP04511
(show subtarget assignments)

1

cloned

No

CPF_2297

110798696

stage II sporulation protein P [Clostrid...

361

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01006
(show subtarget assignments)

1

soluble

No

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02043
(show subtarget assignments)

1

expressed

No

Cj1145c

15792470

hypothetical protein Cj1145c [Campylobac...

105

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02749
(show subtarget assignments)

1

soluble

No

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP02045
(show subtarget assignments)

1

cloned

No

FTT0749c

56707864

hypothetical protein FTT0749c [Francisel...

328

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3AIM

25.6%

Francisella tularensis

Central intermediary metabolism

Other

IDP04192
(show subtarget assignments)

1

cloned

No

CPF_0671

110799768

phosphoribosylformylglycinamidine syntha...

1266

conserved gene; putative drug target function;

Phase 4: April 2009

3AC6

15.2%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04017
(show subtarget assignments)

1

cloned

No

CPF_1035

110799411

putative lipoprotein [Clostridium perfri...

309

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP02048
(show subtarget assignments)

1

expressed

No

STM3737

16767022

putative Zn-dependent hydrolase [Salmone...

293

Conserved; Drug target functions

Phase 3: June 2008

1JT1

30.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP02049
(show subtarget assignments)

1

expressed

No

STM3122

16766422

putative arylsulfatase [Salmonella typhi...

579

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1HDH

36.1%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP02138
(show subtarget assignments)

1

expressed

No

Cj0580c

15791940

coproporphyrinogen III oxidase [Campylob...

355

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

22.5%

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP02051
(show subtarget assignments)

1

cloned

No

STM4141

16767399

putative cytoplasmic protein [Salmonella...

57

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02052
(show subtarget assignments)

1

cloned

No

YPO2924

16123111

hypothetical protein YPO2924 [Yersinia p...

215

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP02053
(show subtarget assignments)

1

soluble

No

YPO3699

16123838

hypothetical protein YPO3699 [Yersinia p...

158

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3OD9

32.9%

Yersinia pestis

Cell envelope

Other

IDP04152
(show subtarget assignments)

1

cloned

No

YPO3919

218930919

HlyD family secretion protein [Yersinia ...

442

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02598
(show subtarget assignments)

1

cloned

No

Cj1429c

15792747

hypothetical protein Cj1429c [Campylobac...

308

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02056
(show subtarget assignments)

1

expressed

No

CBU_0934

29541521

ABC transporter, ATP-binding protein [Co...

304

Conserved; Drug target functions

Phase 3: June 2008

1VPL

27.6%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04305
(show subtarget assignments)

1

cloned

No

CPF_2386

110798631

ribonuclease [Clostridium perfringens AT...

480

conserved gene; putative drug target function;

Phase 4: April 2009

2BX2

27.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04506
(show subtarget assignments)

1

cloned

No

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP02059
(show subtarget assignments)

1

expressed

No

YPO1353

16121633

chorismate mutase [Yersinia pestis CO92]...

186

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2GBB

83.9%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP02060
(show subtarget assignments)

1

expressed

No

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04079
(show subtarget assignments)

1

purified

No

BAS0100

49183134

50S ribosomal protein L7/L12 [Bacillus a...

119

Proposed to be essential proteins

Phase 4: April 2009

1DD3

63.3%

Bacillus anthracis

IDP04371
(show subtarget assignments)

1

expressed

No

GBAA4776

47778322

sensor histidine kinase [Bacillus anthra...

311

putative drug target function;

Phase 4: April 2009

2C2A

19.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04375
(show subtarget assignments)

1

expressed

No

VCA0211

15600980

sensory box sensor histidine kinase [Vib...

648

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3D36

9.7%

Vibrio cholerae

Regulatory functions

Other

IDP02064
(show subtarget assignments)

1

cloned

No

YPO3878

16124011

putative fimbrial chaperone [Yersinia pe...

243

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.5%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02065
(show subtarget assignments)

1

in_pdb
3IAC

No

STM3137

16766437

glucuronate isomerase [Salmonella typhim...

470

Conserved; Drug target functions

Phase 3: June 2008

3IAC

100%

Salmonella enterica

Energy metabolism

Sugars

IDP02262
(show subtarget assignments)

1

purified

No

FTT1532

56708566

hypothetical protein FTT1532 [Francisell...

162

Drug Target

Phase 3: June 2008

3NWZ

16%

Francisella tularensis

Unknown function

General

IDP02067
(show subtarget assignments)

1

purified

No

FTT0825c

56707936

hypothetical protein FTT0825c [Francisel...

111

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP00057
(show subtarget assignments)

1

soluble

No

BA_3900

30258414

lantibiotic biosynthesis DNA-binding res...

220

Virulence

Phase 1: October 2007

2GWR

34.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02369
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3204

47778134

short chain dehydrogenase [Bacillus anth...

257

Conserved; Essential;

Phase 3: June 2008

3ICC

61.9%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02070
(show subtarget assignments)

1

expressed

No

CBU_1809

29542365

ABC transporter, ATP-binding protein [Co...

221

Conserved; Drug target functions

Phase 3: June 2008

1F3O

49.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02233
(show subtarget assignments)

1

cloned

No

lmo0056

16802104

hypothetical protein lmo0056 [Listeria m...

97

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

2VRZ

50.5%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP02072
(show subtarget assignments)

1

soluble

No

FTT0554

56707684

hypothetical protein FTT0554 [Francisell...

90

Drug Target

Phase 3: June 2008

4ADZ

35.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP02073
(show subtarget assignments)

1

expressed

No

CBU_0418

29541027

4-amino-4-deoxychorismate lyase, putativ...

281

Conserved; Drug target functions

Phase 3: June 2008

3LUL

28.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02278
(show subtarget assignments)

1

expressed

No

Cj0045c

15791444

putative iron-binding protein [Campyloba...

240

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2AWC

13.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04021
(show subtarget assignments)

1

expressed

No

BAS3695

49186694

30S ribosomal protein S16 [Bacillus anth...

90

Proposed to be essential proteins

Phase 4: April 2009

1EMW

42.2%

Bacillus anthracis

IDP02076
(show subtarget assignments)

1

soluble

No

STM3216

16766515

putative methyl-accepting chemotaxis pro...

521

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

28.6%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP02077
(show subtarget assignments)

1

soluble

No

YPO0271

16120610

putative type III secretion apparatus pr...

97

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02078
(show subtarget assignments)

1

expressed

No

YPO0268

16120606

type III secretion system apparatus prot...

133

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02079
(show subtarget assignments)

1

expressed

No

Cj0173c

15791560

iron ABC transporter, ATP binding subuni...

302

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2D62

35.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04705
(show subtarget assignments)

1

cloned

No

YPO0499

115346308

hypothetical protein [Yersinia pestis CO...

337

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP02081
(show subtarget assignments)

1

cloned

No

Cj1340c

15792663

hypothetical protein Cj1340c [Campylobac...

605

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01026
(show subtarget assignments)

1

cloned

No

STM1267

16764618

putative cytoplasmic protein

82

Conserved Gene / Pathway

Phase 2: March 2008

2OXL

32.9%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP02440
(show subtarget assignments)

1

cloned

No

lmo0331

16802376

hypothetical protein lmo0331 [Listeria m...

633

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

3BZ5

28.4%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP00251
(show subtarget assignments)

1

cloned

No

MVEVgp1

9633623

Murray Valley encephalitis Envelope prot...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3P54

78.1%

Murray Valley

IDP04662
(show subtarget assignments)

1

cloned

No

GBAA0650

47525929

sensor histidine kinase [Bacillus anthra...

463

putative drug target function;

Phase 4: April 2009

2C2A

17.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP05265
(show subtarget assignments)

1

purified

No

CD3543

126701167

putative nicotinate phosphribosyltransfe...

476

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2F7F

43.3%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04590
(show subtarget assignments)

1

expressed

No

BAS0136

49183170

30S ribosomal protein S11 [Bacillus anth...

129

Proposed to be essential proteins

Phase 4: April 2009

1VS5

65.9%

Bacillus anthracis

IDP00058
(show subtarget assignments)

1

soluble

No

BA_3903

30258417

bacteriocin ABC transporter, ATP-binding...

234

Virulence

Phase 1: October 2007

1OXS

32.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02532
(show subtarget assignments)

1

cloned

No

GBAA1879

47527172

M23/37 family peptidase [Bacillus anthra...

262

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04486
(show subtarget assignments)

1

cloned

No

YPO3597

115349218

conserved hypothetical protein [Yersinia...

448

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP02420
(show subtarget assignments)

1

expressed

No

YPO1501

16121774

putative esterase [Yersinia pestis CO92]...

280

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

3I6Y

58.9%

Yersinia pestis

Central intermediary metabolism

Other

IDP02092
(show subtarget assignments)

1

cloned

No

YPO0259

16120596

putative type III secretion apparatus [Y...

73

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00252
(show subtarget assignments)

1

in_crystallization_trials

No

130516

St. Louis encephalitis virus Envelope pr...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

2I69

70.5%

St. Louis

IDP02094
(show subtarget assignments)

1

cloned

No

STM3598

16766884

putative L-asparaginase [Salmonella typh...

347

Conserved; Drug target functions

Phase 3: June 2008

1ZCF

68.9%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP02174
(show subtarget assignments)

1

cloned

No

YPO3031

16123208

putative acetyltransferase [Yersinia pes...

141

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2PDO

78%

Yersinia pestis

Central intermediary metabolism

Other

IDP04668
(show subtarget assignments)

1

cloned

No

GBAA1327

47526592

phaP protein [Bacillus anthracis str. 'A...

174

conserved gene; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04691
(show subtarget assignments)

1

soluble

No

GBAA5067

47530367

sensory box histidine kinase [Bacillus a...

617

putative drug target function;

Phase 4: April 2009

3A0R

10.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04542
(show subtarget assignments)

1

expressed

No

YPO2000

218929110

putative two-component system sensor pro...

463

putative drug target function;

Phase 4: April 2009

3JZ3

13.2%

Yersinia pestis

Regulatory functions

Other

IDP02099
(show subtarget assignments)

1

cloned

No

FTT0972

56708065

ABC transporter, ATP-binding protein [Fr...

249

Conserved; Drug target functions

Phase 3: June 2008

2D3W

57.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00253
(show subtarget assignments)

1

in_crystallization_trials

No

YFVgp1

9627245

Yellow fever virus Envelope protein

399

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1P58

43.8%

Yellow fever

IDP02163
(show subtarget assignments)

1

cloned

No

GBAA3914

47529205

phosphodiesterase [Bacillus anthracis st...

520

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

General

IDP02329
(show subtarget assignments)

1

in_pdb
3KQF

Yes

GBAA2551

47527840

enoyl-CoA hydratase [Bacillus anthracis ...

262

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3KQF

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04181
(show subtarget assignments)

1

crystallized

No

VCA0197

9657589

GMP reductase [Vibrio cholerae O1 biovar...

347

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2A7R

63.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02104
(show subtarget assignments)

1

soluble

No

YPO1074

16121375

D,D-heptose 1,7-bisphosphate phosphatase...

188

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2GMW

80.9%

Yersinia pestis

Unknown function

General

IDP02105
(show subtarget assignments)

1

cloned

No

lmo0063

16802111

hypothetical protein lmo0063 [Listeria m...

99

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP04071
(show subtarget assignments)

1

cloned

No

BAS0129

49183163

50S ribosomal protein L15 [Bacillus anth...

146

Proposed to be essential proteins

Phase 4: April 2009

1VSA

51.4%

Bacillus anthracis

IDP02107
(show subtarget assignments)

1

cloned

No

GBAA2607

47778067

lipase, putative [Bacillus anthracis str...

400

Conserved; Involved in sporulation; Vaccine Target; Drug target functions

Phase 3: June 2008

2DSN

48%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP00254
(show subtarget assignments)

1

in_pdb
3P54

Yes

13272205

Japanese encephalitis virus Envelope pro...

406

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3P54

98.3%

Japanese encephalitis

IDP02109
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1186

16121481

hypothetical protein YPO1186 [Yersinia p...

157

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Hypothetical proteins

Conserved

IDP02110
(show subtarget assignments)

1

expressed

No

STM3820

16767105

putative cytochrome c peroxidase [Salmon...

466

Conserved; Drug target functions

Phase 3: June 2008

1IQC

29.4%

Salmonella enterica

Cellular processes

Detoxification

IDP02325
(show subtarget assignments)

1

in_pdb
3IMF

No

GBAA4204

47778260

short chain dehydrogenase [Bacillus anth...

254

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3IMF

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP04091
(show subtarget assignments)

1

cloned

No

CPF_1278

110799680

putative lipoprotein [Clostridium perfri...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04404
(show subtarget assignments)

1

cloned

No

VC2602

15642597

adenylosuccinate synthetase [Vibrio chol...

432

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KJX

75.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04028
(show subtarget assignments)

1

purified

No

BAS0109

49183143

30S ribosomal protein S10 [Bacillus anth...

102

Proposed to be essential proteins

Phase 4: April 2009

1P6G

61.8%

Bacillus anthracis

IDP02115
(show subtarget assignments)

1

purified

No

FTT0900

56708001

hypothetical protein FTT0900 [Francisell...

123

Drug Target

Community Requests

2GM2

22.8%

Francisella tularensis

Cell envelope

Other

IDP00059
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4013

30258522

fibronectin/fibrinogen-binding protein, ...

569

Virulence

Phase 1: October 2007

3DOA

22.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP04419
(show subtarget assignments)

1

soluble

No

GBAA2861

47528156

sensor histidine kinase SrrB, putative [...

458

putative drug target function;

Phase 4: April 2009

2C2A

18.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02348
(show subtarget assignments)

1

soluble

No

GBAA2803

47528096

S-layer protein, putative [Bacillus anth...

461

Drug target motif; Drug target functions

Phase 3: June 2008

3PYW

12.4%

Bacillus anthracis

Cell envelope

Surface structures

IDP02269
(show subtarget assignments)

1

cloned

No

Cj0608

15791968

outer membrane efflux protein [Campyloba...

456

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

3PIK

23.7%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP02120
(show subtarget assignments)

1

expressed

No

YPO0027

16120380

phosphatase [Yersinia pestis CO92]

196

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2B0C

66.8%

Yersinia pestis

Unknown function

General

IDP02121
(show subtarget assignments)

1

cloned

No

FTT0360

56707511

Short-chain dehydrogenase/reductase [Fra...

274

Drug Target

Phase 3: June 2008

1FDW

27.7%

Francisella tularensis

Central intermediary metabolism

Other

IDP01046
(show subtarget assignments)

1

expressed

No

STM3138

16766438

putative methyl-accepting chemotaxis pro...

352

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

16.8%

Salmonella enterica

Cellular processes

Other

IDP02123
(show subtarget assignments)

1

purified

No

YPO1255

16121542

hypothetical protein YPO1255 [Yersinia p...

120

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Hypothetical proteins

Conserved

IDP01047
(show subtarget assignments)

1

cloned

No

STM3152

16766452

putative methyl-accepting chemotaxis pro...

547

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

34.7%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP02274
(show subtarget assignments)

1

in_pdb
3IJ5

Yes

YPO3578

16123722

3-deoxy-D-manno-octulosonate 8-phosphate...

187

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3IJ5

100%

Yersinia pestis

Hypothetical proteins

Conserved

IDP02126
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1221

56708283

hypothetical protein FTT1221 [Francisell...

88

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelopeRegulatory functions,Unknown function

Biosynthesis and degradation of murein sacculus and peptidoglycanOther,General

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP90162
(show subtarget assignments)

8

purified

No

CD1833

123174272

3-dehydroquinate synthase

354

Potential drug target. Shikimate pathway enzyme

Community Requests

3OKF

40.1%

Clostridium difficile

IDP90161
(show subtarget assignments)

8

purified

No

CD1835

123174273

Chorismate synthase (5-enolpyruvylshikim...

359

Potential drug target. Shikimate pathway enzyme

Community Requests

1UM0

38.7%

Clostridium difficile