Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00536 (show subtarget assignments)	1	purified	No	YPO4003	16124128	dppA	periplasmic dipeptide transport protein ...	535	Virulence Associated Factor	Phase 2: March 2008	1DPP	81.5%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00569 (show subtarget assignments)	1	purified	No	YPO4016	16124139	hutH	histidine ammonia-lyase	510	Drug Target Function	Phase 2: March 2008	1GK2	77.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00516 (show subtarget assignments)	1	purified	No	YPO4022	16124145		putative iron transport protein	317	Conserved Gene / Pathway	Phase 2: March 2008	3GFV	34.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00176 (show subtarget assignments)	1	cloned	No	YPO4024	16124147	-	putative iron transport permease	335	Virulence	Phase 1: October 2007	2QI9	23.9%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00405 (show subtarget assignments)	1	purified	No	YPO4025	16124148		putative iron ABC transporter, ATP-bindi...	252	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.3%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00543 (show subtarget assignments)	1	purified	No	YPO4057	16124173	fdoH	formate dehydrogenase-O, iron-sulfur sub...	323	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	70.9%	Yersinia pestis	Energy metabolism	Anaerobic

IDP90610 (show subtarget assignments)	8	soluble	No	YPO4071	16124184	glyS	glycyl-tRNA synthetase subunit beta [Yer...	689	Predicted Essential	Community Requests			Yersinia pestis

IDP90819 (show subtarget assignments)	8	purified	No	YPO4094	16124203	gyrB	DNA gyrase subunit B [Yersinia pestis CO...	804	Predicted Essential	Community Requests	1EI1	43.7%	Yersinia pestis

IDP90731 (show subtarget assignments)	8	soluble	No	YPO4101	16124209	rnpA	ribonuclease P [Yersinia pestis CO92]	119	Predicted Essential	Community Requests	2LJP	89.1%	Yersinia pestis

IDP00427 (show subtarget assignments)	1	in_pdb 3FWW	No	YPO4119	16124227	glmU	bifunctional N-acetylglucosamine-1-phosp...	456	Drug Target Function	Phase 2: March 2008	3FWW	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91767 (show subtarget assignments)	8	soluble	No	b1584	16129542	speG	spermidine N1-acetyltransferase [Escheri...	186	drug resistance; innate immunity / E.coli speG (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...	Community Requests	3EG7	53.8%	Escherichia coli

IDP91766 (show subtarget assignments)	8	expressed	No	b3441	16131313	yhhY	predicted acetyltransferase [Escherichia...	162	drug resistance; innate immunity / E.coli YhhY (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...	Community Requests	2VI7	39.5%	Escherichia coli

IDP91249 (show subtarget assignments)	8	soluble	No	NT01LM0800	16410126	lmo0737	lmo0737 [Listeria monocytogenes]	310	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP91250 (show subtarget assignments)	8	expressed	No	NT01LM1295	16410617	lmo1201	lmo1201 [Listeria monocytogenes]	493	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	24.9%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91251 (show subtarget assignments)	8	expressed	No	NT01LM1754	16411067	trpD	trpD [Listeria monocytogenes]	339	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	41.2%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP91762 (show subtarget assignments)	8	crystallized	No	CAC99716	16411074	lmo1638	lmo1638 [Listeria monocytogenes EGD-e]	324	drug resistance; innate immunity / Listeria monocytogenes MccF-like (MccF homolog) - E.coli MccF confers immunity t...	Community Requests	4E5S	55.8%	Listeria monocytogenes

IDP91252 (show subtarget assignments)	8	soluble	No	NT01LM1948	16411261	fabG	fabG [Listeria monocytogenes]	247	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2UVD	66.4%	Listeria monocytogenes	Fatty acid and phospholipid metabolism: Biosynthesis

IDP91253 (show subtarget assignments)	8	soluble	No	NT01LM1950	16411263	plsX	plsX [Listeria monocytogenes]	337	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1U7N	57.6%	Listeria monocytogenes	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00083 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0073	16418570	caiA	putative acyl-CoA dehydrogenase, carniti...	380	Essential	Phase 1: October 2007	2DVL	32.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00068 (show subtarget assignments)	0	work_stopped	No	NT01ST0271	16418722	pyrH	uridylate kinase	241	Essential	Phase 1: October 2007	2BNE	97.9%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00069 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0342	16418853	STM0352	putative cation efflux pump	408	Virulence	Phase 1: October 2007	1T5E	31.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00089 (show subtarget assignments)	0	work_stopped	No	NT01ST0526	16418927	dxs	1-deoxyxylulose-5-phosphate synthase; fl...	620	Essential	Phase 1: October 2007	2O1S	96.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00084 (show subtarget assignments)	1	expressed	No	NT01ST1435	16419673	yceI	putative secreted protein	191	Essential	Phase 1: October 2007	1Y0G	91.1%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00070 (show subtarget assignments)	0	work_stopped	No	NT01ST1465	16419700	flgK	hook-filament junction protein 1	553	Virulence	Phase 1: October 2007	2D4Y	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00085 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST1174	16419726	nagZ	putative glycosyl hydrolase	341	Virulence	Phase 1: October 2007	1TR9	55.4%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00086 (show subtarget assignments)	1	in_pdb 3DR6 3DR8	No	NT01ST1973	16420114	yncA	putative acyltransferase	171	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DR6	100%	Salmonella enterica	Transport and binding proteins	Other

IDP00071 (show subtarget assignments)	0	work_stopped	No	NT01ST2260	16420352	yeaZ	putative molecular chaperone	231	Essential	Phase 1: October 2007	2GEL	100%	Salmonella enterica	Unknown function	General

IDP00072 (show subtarget assignments)	1	purified	No	NT01ST2585	16420605	hisB	imidazole glycerol-phosphate dehydratase...	355	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FPR	43.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00087 (show subtarget assignments)	1	expressed	No	NTL01ST2379	16420989	STM2449	putative acetyltransferase	178	Virulence	Phase 1: October 2007	2PDO	75.3%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00088 (show subtarget assignments)	8	in_crystallization_trials	No	NT01ST3082	16421025	dapE	N-succinyl-diaminopimelate deacylase	375	Essential	Community Requests	3IC1	61.9%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP00073 (show subtarget assignments)	1	crystallized	No	NT01ST3324	16421221	rimM	16S rRNA processing protein	182	Essential	Phase 1: October 2007	3H9N	63.2%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00074 (show subtarget assignments)	0	work_stopped	No	NT01ST3685	16421504	pyrG	CTP synthetase	545	Essential	Phase 1: October 2007	1S1M	95%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00075 (show subtarget assignments)	0	work_stopped	No	NTL01ST3174	16421824	yraO	putative phosphoheptose isomerase	196		Phase 1: October 2007	2YVA	98%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00076 (show subtarget assignments)	1	in_pdb 3NX4	No	NT01ST4228	16421936	yhdH	putative oxidoreductase	324	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3NX4	100%	Salmonella enterica	Cellular processes	Cell division

IDP00077 (show subtarget assignments)	0	work_stopped	No	NTL01ST3489	16422154	yhiQ	putative SAM-dependent methyltransferase...	252		Phase 1: October 2007	2PKW	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00078 (show subtarget assignments)	0	work_stopped	No	NTL01ST3606	16422278	rfaF	ADP-heptose; LPS heptosyltransferase 1	348		Phase 1: October 2007	1PSW	91.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00079 (show subtarget assignments)	1	in_pdb 3DSA 3E7N	No	NT01ST4845	16422456	rbsD	D-ribose high-affinity transport system ...	139	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00080 (show subtarget assignments)	1	expressed	No	NT01ST5073	16422645	yneC	putative inner membrane protein	109	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3QMQ	70.6%	Salmonella enterica	Cell envelope	Other

IDP00081 (show subtarget assignments)	1	in_crystallization_trials	No	NT01ST5473	16422973	ytfP	putative cytoplasmic protein	114	Essential	Phase 1: October 2007	1XHS	92.1%	Salmonella enterica	Unknown function	General

IDP00082 (show subtarget assignments)	0	work_stopped	No	NTL01ST4427	16423142	lplA	lipoate-protein ligase A	338		Phase 1: October 2007	1X2G	93.2%	Salmonella enterica	Cell envelope	Other

IDP91799 (show subtarget assignments)	8	selected	No	AAL27442	16612079	vanE	VanE [Enterococcus faecalis]	352	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1E4E	41.5%	Enterococcus faecalis

IDP91775 (show subtarget assignments)	8	in_crystallization_trials	No	AAL27443	16612080	vanXYE	VanXYE [Enterococcus faecalis]	193	drug resistance / D,D-dipeptidase/D,D-carboxypeptidase	Community Requests			Enterococcus faecalis

IDP00901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0004	16763394	thrC	threonine synthase	428	Conserved Gene / Pathway	Phase 2: March 2008	1VB3	93.5%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01845 (show subtarget assignments)	1	cloned	No	STM0017	16763407		hypothetical protein STM0017 [Salmonella...	147	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP01021 (show subtarget assignments)	1	cloned	No	STM0044	16763434	yaaY	putative cytoplasmic protein	71	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00902 (show subtarget assignments)	1	expressed	No	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90764 (show subtarget assignments)	8	purified	No	STM0046	16763436	ileS	isoleucyl-tRNA synthetase [Salmonella ty...	944	Predicted Essential	Community Requests	1FFY	42.2%	Salmonella enterica

IDP01022 (show subtarget assignments)	1	in_crystallization_trials	No	STM0048	16763438	slpA	FKBP-type peptidyl-prolyl cis-trans isom...	149	Conserved Gene / Pathway	Phase 2: March 2008	3PR9	29.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01886 (show subtarget assignments)	1	in_crystallization_trials	No	STM0085	16763475	yabF	glutathione-regulated potassium-efflux s...	176	Conserved; Drug target functions	Phase 3: June 2008	3EYW	87.5%	Salmonella enterica	Energy metabolism	Electron transport

IDP01883 (show subtarget assignments)	1	expressed	No	STM0116	16763506	ilvI	acetolactate synthase 3 catalytic subuni...	553	Conserved; Drug target functions	Phase 3: June 2008	1JSC	43.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP00903 (show subtarget assignments)	0	work_stopped	No	STM0123	16763513	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	495	Essential Gene	Phase 2: March 2008	1E8C	91.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00904 (show subtarget assignments)	0	work_stopped	No	STM0124	16763514	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	87.6%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905 (show subtarget assignments)	0	work_stopped	No	STM0126	16763516	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	438	Essential Gene	Phase 2: March 2008	1E0D	92.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00906 (show subtarget assignments)	0	work_stopped	No	STM0129	16763519	murC	UDP-N-acetylmuramate--L-alanine ligase	491	Essential Gene	Phase 2: March 2008	2F00	94.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00872 (show subtarget assignments)	1	cloned	No	STM0138	16763528	yacG	zinc-binding protein	63	Conserved Gene / Pathway	Phase 2: March 2008	1LV3	85.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00907 (show subtarget assignments)	1	in_crystallization_trials	No	STM0140	16763530	coaE	dephospho-CoA kinase	206	Conserved Gene / Pathway	Phase 2: March 2008	1N3B	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00908 (show subtarget assignments)	1	expressed	No	STM0143	16763533	hofB	hypothetical protein STM0143	461	Conserved Gene / Pathway	Phase 2: March 2008	1P9R	37.3%	Salmonella enterica	Cell envelope	Surface structures

IDP00855 (show subtarget assignments)	1	in_crystallization_trials	No	STM0146	16763536	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	187	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	89.8%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00909 (show subtarget assignments)	0	work_stopped	No	STM0171	16763561	yadF	carbonic anhydrase	220	Conserved Gene / Pathway	Phase 2: March 2008	3QY1	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP90797 (show subtarget assignments)	8	in_pdb 3MUE	No	STM0181	16763571	panC	pantoate--beta-alanine ligase [Salmonell...	284	Predicted Essential	Community Requests	3MUE	100%	Salmonella enterica

IDP00910 (show subtarget assignments)	1	cloned	No	STM0190	16763580	mrcB	penicillin-binding protein 1b	840	Drug Target Function	Phase 2: March 2008	3FWL	84%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00911 (show subtarget assignments)	1	expressed	No	STM0191	16763581	fhuA	ferrichrome outer membrane transporter	729	Conserved Gene / Pathway	Phase 2: March 2008	2FCP	72.3%	Salmonella enterica	Cell envelope	Other

IDP00912 (show subtarget assignments)	1	soluble	No	STM0193	16763583	fhuD	iron-hydroxamate transporter substrate-b...	296	Conserved Gene / Pathway	Phase 2: March 2008	1ESZ	75%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP01889 (show subtarget assignments)	1	soluble	No	STM0209	16763599	htrA	serine endoprotease [Salmonella typhimur...	475	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2ZLE	87.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00879 (show subtarget assignments)	1	purified	No	STM0211	16763601	yaeH	putative cytoplasmic protein	128	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00913 (show subtarget assignments)	0	work_stopped	No	STM0219	16763609	frr	ribosome recycling factor	185	Conserved Gene / Pathway	Phase 2: March 2008	1EK8	94.1%	Salmonella enterica	Protein synthesis	Translation factors

IDP00914 (show subtarget assignments)	1	soluble	No	STM0220	16763610	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	398	Conserved Gene / Pathway	Phase 2: March 2008	1K5H	88.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01019 (show subtarget assignments)	0	work_stopped	No	STM0228	16763618	lpxA	UDP-N-acetylglucosamine acyltransferase ...	262	Essential Gene	Phase 2: March 2008	1LXA	93.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00116 (show subtarget assignments)	0	work_stopped	No	NT01ST0285	16763622	accA	acetylCoA carboxylase, carboxytransferas...	319	Essential	Phase 1: October 2007	2F9Y	96.9%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00915 (show subtarget assignments)	1	in_crystallization_trials	No	STM0236	16763626	tilS	tRNA(Ile)-lysidine synthetase	430	Drug Target Function	Phase 2: March 2008	1NI5	75.3%	Salmonella enterica	Cellular processes	Cell division

IDP00117 (show subtarget assignments)	1	purified	No	NT01ST0298	16763632	yaeB	putative regulatory protein	235	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1XQB	47.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00916 (show subtarget assignments)	0	work_stopped	No	STM0247	16763636	metN	DL-methionine transporter ATP-binding su...	343	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	95.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP02578 (show subtarget assignments)	1	expressed	No	STM0262	16763645	yafS	putative SAM-dependent methyltransferase...	240	Conserved; Drug target functions	Phase 3: June 2008	1VLM	11.7%	Salmonella enterica	Unknown function	General

IDP04055 (show subtarget assignments)	1	cloned	No	STM0301_1_836	16763684	safC	putative fimbrial usher [Salmonella typh...	836	Salmonella essential protein	Phase 4: April 2009	3RFZ	37%	Salmonella enterica

IDP00124 (show subtarget assignments)	0	work_stopped	No	NT01ST0382	16763693	ghmA	phosphoheptose isomerase	192		Phase 1: October 2007	2I22	97.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01787 (show subtarget assignments)	1	crystallized	No	STM0332	16763712		putative hydrolase/acyltransferase [Salm...	304	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3QYJ	47.4%	Salmonella enterica	Cellular processes	Detoxification

IDP02343 (show subtarget assignments)	1	expressed	No	STM0345	16763725		putative inner membrane protein [Salmone...	162	Essential; Drug target functions	Phase 3: June 2008			Salmonella enterica	Hypothetical proteins	Conserved

IDP00917 (show subtarget assignments)	1	cloned	No	STM0355	16763735		putative copper chaperone	64	Conserved Gene / Pathway	Phase 2: March 2008	2K2P	39.1%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00853 (show subtarget assignments)	1	purified	No	STM0359	16763739		putative cytoplasmic protein	33	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00918 (show subtarget assignments)	1	soluble	No	STM0372	16763752	hemB	delta-aminolevulinic acid dehydratase	324	Conserved Gene / Pathway	Phase 2: March 2008	1I8J	93.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02785 (show subtarget assignments)	1	cloned	No	STM0378	16763758	yaiY	putative inner membrane protein [Salmone...	102	Conserved; Essential; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cell envelope	Other

IDP00919 (show subtarget assignments)	1	in_pdb 3Q1K 3I12	No	STM0380	16763760	ddl	D-alanyl-alanine synthetase A	364	Conserved Gene / Pathway	Phase 2: March 2008	3I12	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00856 (show subtarget assignments)	1	purified	No	STM0388	16763768	aroL	shikimate kinase II	181	Conserved Gene / Pathway	Phase 2: March 2008	1SHK	48.6%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP04211 (show subtarget assignments)	1	expressed	No	STM0408_1_323	16763788	secF	preprotein translocase subunit SecF [Sal...	323	Salmonella essential protein	Phase 4: April 2009	3AQP	35.3%	Salmonella enterica

IDP90898 (show subtarget assignments)	8	soluble	No	STM0416	16763796	ribD	bifunctional diaminohydroxyphosphoribosy...	367	Predicted Essential	Community Requests	2G6V	89.4%	Salmonella enterica

IDP00920 (show subtarget assignments)	1	in_crystallization_trials	No	STM0417	16763797	ribH	riboflavin synthase subunit beta	156	Conserved Gene / Pathway	Phase 2: March 2008	3MK3	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02580 (show subtarget assignments)	1	cloned	No	STM0452	16763833	cypD	peptidyl-prolyl cis-trans isomerase (rot...	623	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2KGJ	13.2%	Salmonella enterica	Protein fate	Protein folding and stabilization

IDP02616 (show subtarget assignments)	1	in_pdb 3LHQ	Yes	STM0477	16763857	acrR	DNA-binding transcriptional repressor Ac...	217	Conserved; Drug target functions	Phase 3: June 2008	3LHQ	100%	Salmonella enterica	Transport and binding proteins	Other

IDP00896 (show subtarget assignments)	1	in_pdb 3GA7	No	STM0490	16763870	aes	acetyl esterase	323	Conserved Gene / Pathway	Phase 2: March 2008	3GA7	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01793 (show subtarget assignments)	1	in_pdb 3QDN	No	STM0504	16763884	ybbN	putative thioredoxin protein [Salmonella...	284	Conserved; Drug target functions	Phase 3: June 2008	3QDN	100%	Salmonella enterica	Energy metabolism	Electron transport

IDP00921 (show subtarget assignments)	1	purified	No	STM0507	16763887	ybbA	putative ABC transporter ATP-binding pro...	228	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	42.5%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00922 (show subtarget assignments)	1	soluble	No	STM0533	16763913	purK	phosphoribosylaminoimidazole carboxylase...	355	Conserved Gene / Pathway	Phase 2: March 2008	1B6S	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00880 (show subtarget assignments)	0	work_stopped	No	STM0534	16763914	purE	phosphoribosylaminoimidazole carboxylase...	169	Conserved Gene / Pathway	Phase 2: March 2008	1QCZ	95.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04349 (show subtarget assignments)	1	expressed	No	STM0557_1_550	16763935		putative inner membrane protein [Salmone...	550	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP01894 (show subtarget assignments)	1	in_crystallization_trials	No	STM0564	16763941		pyridine nucleotide-disulfide oxidoreduc...	441	Conserved; Drug target functions	Phase 3: June 2008	2EQ6	32.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01900 (show subtarget assignments)	1	purified	No	STM0570	16763947	apeE	outer membrane esterase [Salmonella typh...	656	Drug target functions	Phase 3: June 2008	3KVN	25.5%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00923 (show subtarget assignments)	1	in_pdb 3HZN	No	STM0578	16763955	nfnB	dihydropteridine reductase	217	Conserved Gene / Pathway	Phase 2: March 2008	3HZN	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00118 (show subtarget assignments)	1	in_pdb 3MGA	No	NT01ST0713	16763963	fes	enterobactin/ferric enterobactin esteras...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3MGA	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00924 (show subtarget assignments)	1	purified	No	STM0590	16763967	fepC	iron-enterobactin transporter ATP-bindin...	264	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	28.4%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00925 (show subtarget assignments)	1	crystallized	No	STM0595	16763972	entC	isochorismate synthase	391	Drug Target Function	Phase 2: March 2008	3HWO	84.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00536
(show subtarget assignments)

1

purified

No

YPO4003

16124128

dppA

periplasmic dipeptide transport protein ...

535

Virulence Associated Factor

Phase 2: March 2008

1DPP

81.5%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00569
(show subtarget assignments)

1

purified

No

YPO4016

16124139

hutH

histidine ammonia-lyase

510

Drug Target Function

Phase 2: March 2008

1GK2

77.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00516
(show subtarget assignments)

1

purified

No

YPO4022

16124145

putative iron transport protein

317

Conserved Gene / Pathway

Phase 2: March 2008

3GFV

34.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00176
(show subtarget assignments)

1

cloned

No

YPO4024

16124147

-

putative iron transport permease

335

Virulence

Phase 1: October 2007

2QI9

23.9%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00405
(show subtarget assignments)

1

purified

No

YPO4025

16124148

putative iron ABC transporter, ATP-bindi...

252

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.3%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00543
(show subtarget assignments)

1

purified

No

YPO4057

16124173

fdoH

formate dehydrogenase-O, iron-sulfur sub...

323

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

70.9%

Yersinia pestis

Energy metabolism

Anaerobic

IDP90610
(show subtarget assignments)

8

soluble

No

YPO4071

16124184

glyS

glycyl-tRNA synthetase subunit beta [Yer...

689

Predicted Essential

Community Requests

Yersinia pestis

IDP90819
(show subtarget assignments)

8

purified

No

YPO4094

16124203

gyrB

DNA gyrase subunit B [Yersinia pestis CO...

804

Predicted Essential

Community Requests

1EI1

43.7%

Yersinia pestis

IDP90731
(show subtarget assignments)

8

soluble

No

YPO4101

16124209

rnpA

ribonuclease P [Yersinia pestis CO92]

119

Predicted Essential

Community Requests

2LJP

89.1%

Yersinia pestis

IDP00427
(show subtarget assignments)

1

in_pdb
3FWW

No

YPO4119

16124227

glmU

bifunctional N-acetylglucosamine-1-phosp...

456

Drug Target Function

Phase 2: March 2008

3FWW

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91767
(show subtarget assignments)

8

soluble

No

b1584

16129542

speG

spermidine N1-acetyltransferase [Escheri...

186

drug resistance; innate immunity / E.coli speG (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...

Community Requests

3EG7

53.8%

Escherichia coli

IDP91766
(show subtarget assignments)

8

expressed

No

b3441

16131313

yhhY

predicted acetyltransferase [Escherichia...

162

drug resistance; innate immunity / E.coli YhhY (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...

Community Requests

2VI7

39.5%

Escherichia coli

IDP91249
(show subtarget assignments)

8

soluble

No

NT01LM0800

16410126

lmo0737

lmo0737 [Listeria monocytogenes]

310

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP91250
(show subtarget assignments)

8

expressed

No

NT01LM1295

16410617

lmo1201

lmo1201 [Listeria monocytogenes]

493

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

24.9%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91251
(show subtarget assignments)

8

expressed

No

NT01LM1754

16411067

trpD

trpD [Listeria monocytogenes]

339

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

41.2%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP91762
(show subtarget assignments)

8

crystallized

No

CAC99716

16411074

lmo1638

lmo1638 [Listeria monocytogenes EGD-e]

324

drug resistance; innate immunity / Listeria monocytogenes MccF-like (MccF homolog) - E.coli MccF confers immunity t...

Community Requests

4E5S

55.8%

Listeria monocytogenes

IDP91252
(show subtarget assignments)

8

soluble

No

NT01LM1948

16411261

fabG

fabG [Listeria monocytogenes]

247

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2UVD

66.4%

Listeria monocytogenes

Fatty acid and phospholipid metabolism: Biosynthesis

IDP91253
(show subtarget assignments)

8

soluble

No

NT01LM1950

16411263

plsX

plsX [Listeria monocytogenes]

337

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1U7N

57.6%

Listeria monocytogenes

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00083
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0073

16418570

caiA

putative acyl-CoA dehydrogenase, carniti...

380

Essential

Phase 1: October 2007

2DVL

32.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00068
(show subtarget assignments)

0

work_stopped

No

NT01ST0271

16418722

pyrH

uridylate kinase

241

Essential

Phase 1: October 2007

2BNE

97.9%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00069
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0342

16418853

STM0352

putative cation efflux pump

408

Virulence

Phase 1: October 2007

1T5E

31.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00089
(show subtarget assignments)

0

work_stopped

No

NT01ST0526

16418927

dxs

1-deoxyxylulose-5-phosphate synthase; fl...

620

Essential

Phase 1: October 2007

2O1S

96.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00084
(show subtarget assignments)

1

expressed

No

NT01ST1435

16419673

yceI

putative secreted protein

191

Essential

Phase 1: October 2007

1Y0G

91.1%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00070
(show subtarget assignments)

0

work_stopped

No

NT01ST1465

16419700

flgK

hook-filament junction protein 1

553

Virulence

Phase 1: October 2007

2D4Y

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00085
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST1174

16419726

nagZ

putative glycosyl hydrolase

341

Virulence

Phase 1: October 2007

1TR9

55.4%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00086
(show subtarget assignments)

1

in_pdb
3DR6
3DR8

No

NT01ST1973

16420114

yncA

putative acyltransferase

171

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DR6

100%

Salmonella enterica

Transport and binding proteins

Other

IDP00071
(show subtarget assignments)

0

work_stopped

No

NT01ST2260

16420352

yeaZ

putative molecular chaperone

231

Essential

Phase 1: October 2007

2GEL

100%

Salmonella enterica

Unknown function

General

IDP00072
(show subtarget assignments)

1

purified

No

NT01ST2585

16420605

hisB

imidazole glycerol-phosphate dehydratase...

355

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FPR

43.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00087
(show subtarget assignments)

1

expressed

No

NTL01ST2379

16420989

STM2449

putative acetyltransferase

178

Virulence

Phase 1: October 2007

2PDO

75.3%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00088
(show subtarget assignments)

8

in_crystallization_trials

No

NT01ST3082

16421025

dapE

N-succinyl-diaminopimelate deacylase

375

Essential

Community Requests

3IC1

61.9%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP00073
(show subtarget assignments)

1

crystallized

No

NT01ST3324

16421221

rimM

16S rRNA processing protein

182

Essential

Phase 1: October 2007

3H9N

63.2%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00074
(show subtarget assignments)

0

work_stopped

No

NT01ST3685

16421504

pyrG

CTP synthetase

545

Essential

Phase 1: October 2007

1S1M

95%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00075
(show subtarget assignments)

0

work_stopped

No

NTL01ST3174

16421824

yraO

putative phosphoheptose isomerase

196

Phase 1: October 2007

2YVA

98%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00076
(show subtarget assignments)

1

in_pdb
3NX4

No

NT01ST4228

16421936

yhdH

putative oxidoreductase

324

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3NX4

100%

Salmonella enterica

Cellular processes

Cell division

IDP00077
(show subtarget assignments)

0

work_stopped

No

NTL01ST3489

16422154

yhiQ

putative SAM-dependent methyltransferase...

252

Phase 1: October 2007

2PKW

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00078
(show subtarget assignments)

0

work_stopped

No

NTL01ST3606

16422278

rfaF

ADP-heptose; LPS heptosyltransferase 1

348

Phase 1: October 2007

1PSW

91.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00079
(show subtarget assignments)

1

in_pdb
3DSA
3E7N

No

NT01ST4845

16422456

rbsD

D-ribose high-affinity transport system ...

139

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00080
(show subtarget assignments)

1

expressed

No

NT01ST5073

16422645

yneC

putative inner membrane protein

109

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3QMQ

70.6%

Salmonella enterica

Cell envelope

Other

IDP00081
(show subtarget assignments)

1

in_crystallization_trials

No

NT01ST5473

16422973

ytfP

putative cytoplasmic protein

114

Essential

Phase 1: October 2007

1XHS

92.1%

Salmonella enterica

Unknown function

General

IDP00082
(show subtarget assignments)

0

work_stopped

No

NTL01ST4427

16423142

lplA

lipoate-protein ligase A

338

Phase 1: October 2007

1X2G

93.2%

Salmonella enterica

Cell envelope

Other

IDP91799
(show subtarget assignments)

8

selected

No

AAL27442

16612079

vanE

VanE [Enterococcus faecalis]

352

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1E4E

41.5%

Enterococcus faecalis

IDP91775
(show subtarget assignments)

8

in_crystallization_trials

No

AAL27443

16612080

vanXYE

VanXYE [Enterococcus faecalis]

193

drug resistance / D,D-dipeptidase/D,D-carboxypeptidase

Community Requests

Enterococcus faecalis

IDP00901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0004

16763394

thrC

threonine synthase

428

Conserved Gene / Pathway

Phase 2: March 2008

1VB3

93.5%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01845
(show subtarget assignments)

1

cloned

No

STM0017

16763407

hypothetical protein STM0017 [Salmonella...

147

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01021
(show subtarget assignments)

1

cloned

No

STM0044

16763434

yaaY

putative cytoplasmic protein

71

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00902
(show subtarget assignments)

1

expressed

No

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90764
(show subtarget assignments)

8

purified

No

STM0046

16763436

ileS

isoleucyl-tRNA synthetase [Salmonella ty...

944

Predicted Essential

Community Requests

1FFY

42.2%

Salmonella enterica

IDP01022
(show subtarget assignments)

1

in_crystallization_trials

No

STM0048

16763438

slpA

FKBP-type peptidyl-prolyl cis-trans isom...

149

Conserved Gene / Pathway

Phase 2: March 2008

3PR9

29.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01886
(show subtarget assignments)

1

in_crystallization_trials

No

STM0085

16763475

yabF

glutathione-regulated potassium-efflux s...

176

Conserved; Drug target functions

Phase 3: June 2008

3EYW

87.5%

Salmonella enterica

Energy metabolism

Electron transport

IDP01883
(show subtarget assignments)

1

expressed

No

STM0116

16763506

ilvI

acetolactate synthase 3 catalytic subuni...

553

Conserved; Drug target functions

Phase 3: June 2008

1JSC

43.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP00903
(show subtarget assignments)

0

work_stopped

No

STM0123

16763513

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

495

Essential Gene

Phase 2: March 2008

1E8C

91.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00904
(show subtarget assignments)

0

work_stopped

No

STM0124

16763514

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

87.6%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905
(show subtarget assignments)

0

work_stopped

No

STM0126

16763516

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

438

Essential Gene

Phase 2: March 2008

1E0D

92.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00906
(show subtarget assignments)

0

work_stopped

No

STM0129

16763519

murC

UDP-N-acetylmuramate--L-alanine ligase

491

Essential Gene

Phase 2: March 2008

2F00

94.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00872
(show subtarget assignments)

1

cloned

No

STM0138

16763528

yacG

zinc-binding protein

63

Conserved Gene / Pathway

Phase 2: March 2008

1LV3

85.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00907
(show subtarget assignments)

1

in_crystallization_trials

No

STM0140

16763530

coaE

dephospho-CoA kinase

206

Conserved Gene / Pathway

Phase 2: March 2008

1N3B

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00908
(show subtarget assignments)

1

expressed

No

STM0143

16763533

hofB

hypothetical protein STM0143

461

Conserved Gene / Pathway

Phase 2: March 2008

1P9R

37.3%

Salmonella enterica

Cell envelope

Surface structures

IDP00855
(show subtarget assignments)

1

in_crystallization_trials

No

STM0146

16763536

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

187

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

89.8%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00909
(show subtarget assignments)

0

work_stopped

No

STM0171

16763561

yadF

carbonic anhydrase

220

Conserved Gene / Pathway

Phase 2: March 2008

3QY1

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP90797
(show subtarget assignments)

8

in_pdb
3MUE

No

STM0181

16763571

panC

pantoate--beta-alanine ligase [Salmonell...

284

Predicted Essential

Community Requests

3MUE

100%

Salmonella enterica

IDP00910
(show subtarget assignments)

1

cloned

No

STM0190

16763580

mrcB

penicillin-binding protein 1b

840

Drug Target Function

Phase 2: March 2008

3FWL

84%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00911
(show subtarget assignments)

1

expressed

No

STM0191

16763581

fhuA

ferrichrome outer membrane transporter

729

Conserved Gene / Pathway

Phase 2: March 2008

2FCP

72.3%

Salmonella enterica

Cell envelope

Other

IDP00912
(show subtarget assignments)

1

soluble

No

STM0193

16763583

fhuD

iron-hydroxamate transporter substrate-b...

296

Conserved Gene / Pathway

Phase 2: March 2008

1ESZ

75%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP01889
(show subtarget assignments)

1

soluble

No

STM0209

16763599

htrA

serine endoprotease [Salmonella typhimur...

475

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2ZLE

87.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00879
(show subtarget assignments)

1

purified

No

STM0211

16763601

yaeH

putative cytoplasmic protein

128

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00913
(show subtarget assignments)

0

work_stopped

No

STM0219

16763609

frr

ribosome recycling factor

185

Conserved Gene / Pathway

Phase 2: March 2008

1EK8

94.1%

Salmonella enterica

Protein synthesis

Translation factors

IDP00914
(show subtarget assignments)

1

soluble

No

STM0220

16763610

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

398

Conserved Gene / Pathway

Phase 2: March 2008

1K5H

88.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01019
(show subtarget assignments)

0

work_stopped

No

STM0228

16763618

lpxA

UDP-N-acetylglucosamine acyltransferase ...

262

Essential Gene

Phase 2: March 2008

1LXA

93.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00116
(show subtarget assignments)

0

work_stopped

No

NT01ST0285

16763622

accA

acetylCoA carboxylase, carboxytransferas...

319

Essential

Phase 1: October 2007

2F9Y

96.9%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00915
(show subtarget assignments)

1

in_crystallization_trials

No

STM0236

16763626

tilS

tRNA(Ile)-lysidine synthetase

430

Drug Target Function

Phase 2: March 2008

1NI5

75.3%

Salmonella enterica

Cellular processes

Cell division

IDP00117
(show subtarget assignments)

1

purified

No

NT01ST0298

16763632

yaeB

putative regulatory protein

235

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1XQB

47.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00916
(show subtarget assignments)

0

work_stopped

No

STM0247

16763636

metN

DL-methionine transporter ATP-binding su...

343

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

95.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP02578
(show subtarget assignments)

1

expressed

No

STM0262

16763645

yafS

putative SAM-dependent methyltransferase...

240

Conserved; Drug target functions

Phase 3: June 2008

1VLM

11.7%

Salmonella enterica

Unknown function

General

IDP04055
(show subtarget assignments)

1

cloned

No

STM0301_1_836

16763684

safC

putative fimbrial usher [Salmonella typh...

836

Salmonella essential protein

Phase 4: April 2009

3RFZ

37%

Salmonella enterica

IDP00124
(show subtarget assignments)

0

work_stopped

No

NT01ST0382

16763693

ghmA

phosphoheptose isomerase

192

Phase 1: October 2007

2I22

97.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01787
(show subtarget assignments)

1

crystallized

No

STM0332

16763712

putative hydrolase/acyltransferase [Salm...

304

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3QYJ

47.4%

Salmonella enterica

Cellular processes

Detoxification

IDP02343
(show subtarget assignments)

1

expressed

No

STM0345

16763725

putative inner membrane protein [Salmone...

162

Essential; Drug target functions

Phase 3: June 2008

Salmonella enterica

Hypothetical proteins

Conserved

IDP00917
(show subtarget assignments)

1

cloned

No

STM0355

16763735

putative copper chaperone

64

Conserved Gene / Pathway

Phase 2: March 2008

2K2P

39.1%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00853
(show subtarget assignments)

1

purified

No

STM0359

16763739

putative cytoplasmic protein

33

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00918
(show subtarget assignments)

1

soluble

No

STM0372

16763752

hemB

delta-aminolevulinic acid dehydratase

324

Conserved Gene / Pathway

Phase 2: March 2008

1I8J

93.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02785
(show subtarget assignments)

1

cloned

No

STM0378

16763758

yaiY

putative inner membrane protein [Salmone...

102

Conserved; Essential; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cell envelope

Other

IDP00919
(show subtarget assignments)

1

in_pdb
3Q1K
3I12

No

STM0380

16763760

ddl

D-alanyl-alanine synthetase A

364

Conserved Gene / Pathway

Phase 2: March 2008

3I12

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00856
(show subtarget assignments)

1

purified

No

STM0388

16763768

aroL

shikimate kinase II

181

Conserved Gene / Pathway

Phase 2: March 2008

1SHK

48.6%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP04211
(show subtarget assignments)

1

expressed

No

STM0408_1_323

16763788

secF

preprotein translocase subunit SecF [Sal...

323

Salmonella essential protein

Phase 4: April 2009

3AQP

35.3%

Salmonella enterica

IDP90898
(show subtarget assignments)

8

soluble

No

STM0416

16763796

ribD

bifunctional diaminohydroxyphosphoribosy...

367

Predicted Essential

Community Requests

2G6V

89.4%

Salmonella enterica

IDP00920
(show subtarget assignments)

1

in_crystallization_trials

No

STM0417

16763797

ribH

riboflavin synthase subunit beta

156

Conserved Gene / Pathway

Phase 2: March 2008

3MK3

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02580
(show subtarget assignments)

1

cloned

No

STM0452

16763833

cypD

peptidyl-prolyl cis-trans isomerase (rot...

623

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2KGJ

13.2%

Salmonella enterica

Protein fate

Protein folding and stabilization

IDP02616
(show subtarget assignments)

1

in_pdb
3LHQ

Yes

STM0477

16763857

acrR

DNA-binding transcriptional repressor Ac...

217

Conserved; Drug target functions

Phase 3: June 2008

3LHQ

100%

Salmonella enterica

Transport and binding proteins

Other

IDP00896
(show subtarget assignments)

1

in_pdb
3GA7

No

STM0490

16763870

aes

acetyl esterase

323

Conserved Gene / Pathway

Phase 2: March 2008

3GA7

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01793
(show subtarget assignments)

1

in_pdb
3QDN

No

STM0504

16763884

ybbN

putative thioredoxin protein [Salmonella...

284

Conserved; Drug target functions

Phase 3: June 2008

3QDN

100%

Salmonella enterica

Energy metabolism

Electron transport

IDP00921
(show subtarget assignments)

1

purified

No

STM0507

16763887

ybbA

putative ABC transporter ATP-binding pro...

228

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

42.5%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00922
(show subtarget assignments)

1

soluble

No

STM0533

16763913

purK

phosphoribosylaminoimidazole carboxylase...

355

Conserved Gene / Pathway

Phase 2: March 2008

1B6S

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00880
(show subtarget assignments)

0

work_stopped

No

STM0534

16763914

purE

phosphoribosylaminoimidazole carboxylase...

169

Conserved Gene / Pathway

Phase 2: March 2008

1QCZ

95.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04349
(show subtarget assignments)

1

expressed

No

STM0557_1_550

16763935

putative inner membrane protein [Salmone...

550

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP01894
(show subtarget assignments)

1

in_crystallization_trials

No

STM0564

16763941

pyridine nucleotide-disulfide oxidoreduc...

441

Conserved; Drug target functions

Phase 3: June 2008

2EQ6

32.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01900
(show subtarget assignments)

1

purified

No

STM0570

16763947

apeE

outer membrane esterase [Salmonella typh...

656

Drug target functions

Phase 3: June 2008

3KVN

25.5%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00923
(show subtarget assignments)

1

in_pdb
3HZN

No

STM0578

16763955

nfnB

dihydropteridine reductase

217

Conserved Gene / Pathway

Phase 2: March 2008

3HZN

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00118
(show subtarget assignments)

1

in_pdb
3MGA

No

NT01ST0713

16763963

fes

enterobactin/ferric enterobactin esteras...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3MGA

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00924
(show subtarget assignments)

1

purified

No

STM0590

16763967

fepC

iron-enterobactin transporter ATP-bindin...

264

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

28.4%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00925
(show subtarget assignments)

1

crystallized

No

STM0595

16763972

entC

isochorismate synthase

391

Drug Target Function

Phase 2: March 2008

3HWO

84.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

Targets