Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP90726 (show subtarget assignments)	8	purified	No	YPO1390	16121670	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	428	Predicted Essential	Community Requests	1G6S	80.1%	Yersinia pestis

IDP04447 (show subtarget assignments)	1	expressed	No	YPO0690	218927881		putative type II secretion protein [Yers...	428	putative drug target function;	Phase 4: April 2009	2OAP	26.6%	Yersinia pestis	Cell envelope	Surface structures

IDP02617 (show subtarget assignments)	1	expressed	No	GBAA1286	47526551		D-alanyl-D-alanine carboxypeptidase fami...	428	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3MFD	24.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05331 (show subtarget assignments)	1	soluble	No	SACOL0009	57651117	serS	seryl-tRNA synthetase [Staphylococcus au...	428	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2DQ3	51.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP02818 (show subtarget assignments)	1	selected	No	GBAA4027	47529320	pyrC	dihydroorotase [Bacillus anthracis str. ...	428	Conserved; Drug target functions	Phase 3: June 2008	3MPG	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0004	16763394	thrC	threonine synthase	428	Conserved Gene / Pathway	Phase 2: March 2008	1VB3	93.5%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP04208 (show subtarget assignments)	1	purified	No	CPF_2958	110799195	purA	adenylosuccinate synthetase [Clostridium...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1IWE	47.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00179 (show subtarget assignments)	1	cloned	No	YPO0277	16120616	-	putative transmembrane transport protein...	428	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP02337 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1511	47526786	gdhA	glutamate dehydrogenase [Bacillus anthra...	428	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K8Z	84.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP91529 (show subtarget assignments)	8	soluble	No	VC_1312	9655801		alanine racemase, putative [Vibrio chole...	428	other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...	Community Requests	4ECL	24.8%	Vibrio cholerae

IDP90730 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1598	15792903	hisD	histidinol dehydrogenase [Campylobacter ...	428	Predicted Essential	Community Requests	1K75	59.8%	Campylobacter jejuni

IDP92048 (show subtarget assignments)	8	selected	No	TGME49_049270	237835927		thioredoxin, putative [Toxoplasma gondii...	428	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3IDV	20.3%	Toxoplasma gondii

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04490 (show subtarget assignments)	1	in_pdb 3MJF	No	YPO3729	218930734	purD	phosphoribosylamine--glycine ligase [Yer...	428	conserved gene; putative drug target function;	Phase 4: April 2009	3MJF	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02484 (show subtarget assignments)	1	expressed	No	GBAA3922	47529214		zinc protease [Bacillus anthracis str. '...	428	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HDI	24.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01115 (show subtarget assignments)	1	in_pdb 3IG4	No	BA_1901	30256561		xaa-pro aminopeptidase, putative	427	Drug Target Function	Phase 2: March 2008	3IG4	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01016 (show subtarget assignments)	1	cloned	No	STM2792	16766103	gabT	4-aminobutyrate aminotransferase	427	Conserved Gene / Pathway	Phase 2: March 2008	1SF2	88.3%	Salmonella enterica	Central intermediary metabolism	Other

IDP05251 (show subtarget assignments)	1	cloned	No	lmo2747	16804784	serS	seryl-tRNA synthetase [Listeria monocyto...	427	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2DQ3	56.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP00946 (show subtarget assignments)	1	expressed	No	STM0978	16764338	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	427	Conserved Gene / Pathway	Phase 2: March 2008	1G6S	89.5%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00485 (show subtarget assignments)	1	purified	No	YPO1455	16121730		putative beta-ketoacyl-[acyl-carrier-pro...	427	Drug Target Function	Phase 2: March 2008	1J3N	32.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90968 (show subtarget assignments)	8	selected	No					427	Planet Biotechnology company is currently developing an anthrax anti-toxin with ...	Community Requests	1HZH	62.3%	synthetic construct

IDP90749 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1641	15792946	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	427	Predicted Essential	Community Requests	2WTZ	34.4%	Campylobacter jejuni

IDP05556 (show subtarget assignments)	1	soluble	No	lmo1521	16803561	-	hypothetical protein lmo1521 [Listeria m...	427	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3NE8	17.1%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01235 (show subtarget assignments)	1	purified	No	BA_5512	30259972	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	427	Drug Target Function	Phase 2: March 2008	3OJL	62.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90626 (show subtarget assignments)	8	in_pdb 3TI2 3NVS	No	VC1732	15641736		3-phosphoshikimate 1-carboxyvinyltransfe...	426	Predicted Essential	Community Requests	3NVS	100%	Vibrio cholerae

IDP90789 (show subtarget assignments)	8	in_pdb 4E77	No	YPO3389	16123538	hemL	glutamate-1-semialdehyde aminotransferas...	426	Predicted Essential	Community Requests	4E77	100%	Yersinia pestis

IDP04280 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1108	115346887	gltA	citrate synthase GltA [Yersinia pestis C...	426	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1K3P	86.6%	Yersinia pestis	Energy metabolism	TCA cycle

IDP01661 (show subtarget assignments)	1	soluble	No	GBAA4609	47529906		U32 family peptidase [Bacillus anthracis...	426	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90248 (show subtarget assignments)	8	purified	No	BAS0467	49183495		acetylornithine deacetylase [Bacillus an...	426	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3PFO	27%	Bacillus anthracis

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP05687 (show subtarget assignments)	1	cloned	No	lmo1520	16803560	hisS	histidyl-tRNA synthetase [Listeria monoc...	425	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1QE0	53.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05772 (show subtarget assignments)	1	cloned	No	Z3171	12516188	dacD	penicillin binding protein 6b [Escherich...	425	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZO	40.7%	Escherichia coli	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90803 (show subtarget assignments)	8	selected	No	YPO0055	16120408	kdtA	3-deoxy-D-manno-octulosonic-acid transfe...	425	Predicted Essential	Community Requests	2XCI	25.2%	Yersinia pestis

IDP02807 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4705	47530004	tig	trigger factor [Bacillus anthracis str. ...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T11	32.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP04632 (show subtarget assignments)	1	cloned	No	CBU_2005	29655288	rstB	signal transduction histidine kinase-lik...	425	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.2%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP91937 (show subtarget assignments)	8	selected	No	SpneCM_010100003555	298254676		ABC transporter membrane-spanning permea...	425	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP02200 (show subtarget assignments)	1	cloned	No	CBU_1103	29541677		transglycosylase, Slt family [Coxiella b...	425	Conserved; Drug target functions	Phase 3: June 2008	1QSA	16.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02315 (show subtarget assignments)	1	cloned	No	GBAA1132	47526402	aceA	isocitrate lyase [Bacillus anthracis str...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4E	71.4%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP04104 (show subtarget assignments)	1	expressed	No	YPO2309	115348012	rstB	two-component regulatory system, sensor ...	425	putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Yersinia pestis	Regulatory functions	Other

IDP90727 (show subtarget assignments)	8	cloned	No	Cj0853c	15792191	hemL	glutamate-1-semialdehyde aminotransferas...	424	Predicted Essential	Community Requests	3BS8	51.2%	Campylobacter jejuni

IDP04574 (show subtarget assignments)	1	soluble	No	BAS0015	49183051		seryl-tRNA synthetase [Bacillus anthraci...	424	Proposed to be essential proteins	Phase 4: April 2009	2DQ3	57.8%	Bacillus anthracis

IDP90816 (show subtarget assignments)	8	soluble	No	YPO2878	16123070	hisS	histidyl-tRNA synthetase [Yersinia pesti...	424	Predicted Essential	Community Requests	1KMM	82.1%	Yersinia pestis

IDP01721 (show subtarget assignments)	1	cloned	No	Cj1031	15792358		putative outer membrane component of eff...	424	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	2VDD	21.4%	Campylobacter jejuni	Regulatory functions	Other

IDP00795 (show subtarget assignments)	1	in_pdb 3GRI	No	SACOL1213	57285956	pyrC	dihydroorotase	424	Drug Target Function	Phase 2: March 2008	3GRI	100%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04686 (show subtarget assignments)	1	expressed	No	GBAA4223	47529516	kinB-3	sporulation kinase B [Bacillus anthracis...	424	putative drug target function;	Phase 4: April 2009	3D36	22.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04634 (show subtarget assignments)	1	in_pdb 3MSU	No	FTT0071c	56707250	gltA	citrate synthase [Francisella tularensis...	424	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3MSU	100%	Francisella tularensis

IDP00682 (show subtarget assignments)	1	cloned	No	SACOL1777	57286212		serine protease HtrA, putative	424	Drug Target Function	Phase 2: March 2008	2ZLE	29%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05228 (show subtarget assignments)	1	soluble	No	lmo0971	16803011	dltD	DltD protein for D-alanine esterificatio...	380	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3BMA	31.6%	Listeria monocytogenes	Cell envelope: Other

IDP00303 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0035	29653398		beta-ketoacyl synthase	424	Drug Target Function	Phase 2: March 2008	3E60	36.8%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02452 (show subtarget assignments)	1	purified	No	GBAA3312	47528597		diaminobutyrate--2-oxoglutarate aminotra...	424	Conserved; Essential; Drug target functions	Phase 3: June 2008	2EH6	31.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP92107 (show subtarget assignments)	8	selected	No	TGME49_091640	237838437		aspartate carbamoyltransferase [Toxoplas...	423	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1AT1	30.5%	Toxoplasma gondii

IDP00542 (show subtarget assignments)	1	cloned	No	YPO2744	16122948	fadL	long-chain fatty acid outer membrane tra...	423	Virulence Associated Factor	Phase 2: March 2008	1T16	64%	Yersinia pestis	Cell envelope	Other

IDP91960 (show subtarget assignments)	8	selected	No	SpneCM_010100008232	298255567		carbamate kinase [Streptococcus pneumoni...	423	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B7B	24.1%	Streptococcus pneumoniae

IDP02008 (show subtarget assignments)	1	in_crystallization_trials	No	STM3595	16766881		putative phosphatase [Salmonella typhimu...	423	Conserved; Drug target functions	Phase 3: June 2008	2A96	12.8%	Salmonella enterica	Central intermediary metabolism	Other

IDP01885 (show subtarget assignments)	1	cloned	No	GBAA5639	47530965		D-alanyl-D-alanine carboxypeptidase, put...	423	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02239 (show subtarget assignments)	1	expressed	No	GBAA0299	47525562	purD	phosphoribosylamine--glycine ligase [Bac...	423	Conserved; Drug target functions	Phase 3: June 2008	2YRW	64.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00359 (show subtarget assignments)	1	cloned	No	lmo2552	16804590	murZ	UDP-N-acetylglucosamine 1-carboxyvinyltr...	423	Drug Target Function	Phase 2: March 2008	3SG1	50.6%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02647 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0537	16802580		allantoate amidohydrolase [Listeria mono...	423	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3N5F	38.1%	Listeria monocytogenes	Energy metabolism	Amino acids and amines

IDP90854 (show subtarget assignments)	8	crystallized	No	Cj1727c	15793030	metY	putative O-acetylhomoserine (thiol)-lyas...	423	Predicted Essential	Community Requests	2CTZ	40.9%	Campylobacter jejuni

IDP90628 (show subtarget assignments)	8	in_crystallization_trials	No	VC0760	15640779	hisS	histidyl-tRNA synthetase [Vibrio cholera...	422	Predicted Essential	Community Requests	1KMM	74.5%	Vibrio cholerae

IDP02654 (show subtarget assignments)	1	cloned	No	Cj1682c	15792986	gltA	citrate synthase [Campylobacter jejuni s...	422	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	2H12	50.2%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP04281 (show subtarget assignments)	1	cloned	No	YPO1150	115346925	bioA	adenosylmethionine-8-amino-7-oxononanoat...	422	conserved gene; putative drug target function;	Phase 4: April 2009	1MLY	73.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP91684 (show subtarget assignments)	8	selected	No	NCAP_CVHSA	0			422	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SSK	32.9%	SARS coronavirus

IDP90776 (show subtarget assignments)	8	purified	No	STM2365	16765692	folC	bifunctional folylpolyglutamate synthase...	422	Predicted Essential	Community Requests	1W78	86.7%	Salmonella enterica

IDP00722 (show subtarget assignments)	1	purified	No	SACOL1667	57284680		peptidase, U32 family	422	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02143 (show subtarget assignments)	1	expressed	No	CBU_0739	29541339	clpX	ATP-dependent Clp protease, ATP-binding ...	422	Conserved; Drug target functions	Phase 3: June 2008	3HTE	59.5%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04679 (show subtarget assignments)	1	expressed	No	GBAA2644	47527936	kinB-2	sporulation kinase B [Bacillus anthracis...	422	putative drug target function;	Phase 4: April 2009	3D36	27.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP91364 (show subtarget assignments)	8	expressed	No	VV1_2716	27366006		Outer membrane protein [Vibrio vulnificu...	421	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1EK9	23.8%	Vibrio vulnificus

IDP01999 (show subtarget assignments)	1	soluble	No	FTT0942c	56708039	folK	2-amino-4-hydroxy-6-hydroxymethyldihydro...	421	Conserved; Drug target functions	Phase 3: June 2008	3MCM	99.1%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90985 (show subtarget assignments)	8	expressed	No	y0964	22124871		hypothetical protein y0964 [Yersinia pes...	421	other biological interest / -	Community Requests	3MVE	41.8%	Yersinia pestis

IDP90325 (show subtarget assignments)	8	cloned	No	CT089	15604808	lcrE	low calcium response E [Chlamydia tracho...	421	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2VJ4	13.3%	Chlamydia trachomatis

IDP00822 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2253	57285032	femX	femX protein	421	Conserved Gene / Pathway	Phase 2: March 2008	1LRZ	26.7%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00690 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2092	57284959	murAA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	421	Drug Target Function	Phase 2: March 2008	3SG1	64.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04322 (show subtarget assignments)	1	cloned	No	VC1001	15641016		folylpolyglutamate synthase/dihydrofolat...	421	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N2A	53.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00121 (show subtarget assignments)	1	in_pdb 3DQQ	No	NT01ST3629	16766223	ygbK	putative tRNA synthase	420	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DQQ	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02098 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0187	56707352	ftsA	cell division protein FtsA [Francisella ...	420	Conserved; Drug target functions	Phase 3: June 2008	1E4F	24%	Francisella tularensis	Cellular processes	Cell division

IDP04237 (show subtarget assignments)	1	purified	No	CPF_0863	110800564		putative sensor histidine kinase [Clostr...	420	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP01857 (show subtarget assignments)	1	soluble	No	FTT1034c	56708121	ndh	NADH dehydrogenase [Francisella tularens...	420	Drug Target	Phase 3: June 2008	1XHC	21%	Francisella tularensis	Energy metabolism	Electron transport

IDP05358 (show subtarget assignments)	1	cloned	No	BA_0685	30254284		conserved hypothetical protein [Bacillus...	420	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1I84	12.1%	Bacillus anthracis	Hypothetical proteins: Conserved

IDP00434 (show subtarget assignments)	1	cloned	No	YPO0796	16121108	lysA	diaminopimelate decarboxylase	420	Drug Target Function	Phase 2: March 2008	1KNW	76.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00425 (show subtarget assignments)	1	purified	No	YPO3863	16123998	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	420	Conserved Gene / Pathway	Phase 2: March 2008	3OJL	42.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05169 (show subtarget assignments)	1	soluble	No	BA_1952	30256610		NLP/P60 family protein [Bacillus anthrac...	420	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2F68	14%	Bacillus anthracis	Unknown function: General

IDP00702 (show subtarget assignments)	0	work_stopped	No	SACOL0150	57285353	cap5O	capsular polysaccharide biosynthesis pro...	420	Drug Target Function	Phase 2: March 2008	3OJL	98.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00680 (show subtarget assignments)	1	purified	No	SACOL1721	57284732	clpX	ATP-dependent protease ATP-binding subun...	420	Drug Target Function	Phase 2: March 2008	3HWS	52.4%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00594 (show subtarget assignments)	0	work_stopped	No	YPO3569	16123713	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	420	Conserved Gene / Pathway	Phase 2: March 2008	1NAW	91.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90936 (show subtarget assignments)	8	cloned	No	YPO2016	16122259	hemA	glutamyl-tRNA reductase [Yersinia pestis...	420	Predicted Essential	Community Requests	1GPJ	32.9%	Yersinia pestis

IDP91477 (show subtarget assignments)	8	expressed	No	VPA1338	28901193		putative ATPase YscN [Vibrio parahaemoly...	420	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2DPY	34.5%	Vibrio parahaemolyticus

IDP02478 (show subtarget assignments)	1	cloned	No	GBAA4182	47529478	pdhC	branched-chain alpha-keto acid dehydroge...	419	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	74.7%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP05533 (show subtarget assignments)	1	cloned	No	CD2149	126699765		hypothetical protein CD2149 [Clostridium...	419	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP91703 (show subtarget assignments)	8	selected	No	NP_003630	4504631	IKBKG	NF-kappa-B essential modulator isoform a...	419	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	3CL3	29.4%	Homo sapiens

IDP91625 (show subtarget assignments)	8	soluble	No	BAB35496	13361539	ECs2073	hypothetical protein [Escherichia coli O...	419	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3RG1	17.2%	Escherichia coli

IDP00112 (show subtarget assignments)	1	soluble	No	NT01SF5194	30043810	hflK	protease specific for phage lambda cII r...	419	Essential	Phase 1: October 2007	3BK6	11%	Shigella flexneri	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02006 (show subtarget assignments)	1	expressed	No	STM2285	16765612	glpB	anaerobic glycerol-3-phosphate dehydroge...	419	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Energy metabolism	Anaerobic

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04699 (show subtarget assignments)	1	expressed	No	YPCD1.53	16082741	yscD	virulence protein [Yersinia pestis CO92]...	419	virulence factor; conserved gene;	Phase 4: April 2009	4A0E	28.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01846 (show subtarget assignments)	1	soluble	No	CBU_1419	29541979		serine hydroxymethyltransferase [Coxiell...	419	Conserved; Drug target functions	Phase 3: June 2008	1DFO	68.5%	Coxiella burnetii	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP91544 (show subtarget assignments)	8	in_crystallization_trials	No	BAE54319	83627318	ereB	erythromycin esterase type II [Escherich...	419	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2QGM	25.8%	Escherichia coli

IDP91454 (show subtarget assignments)	8	cloned	No	VV1_0254	27363735	hemA	glutamyl-tRNA reductase [Vibrio vulnific...	419	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GPJ	36.3%	Vibrio vulnificus

IDP05595 (show subtarget assignments)	1	soluble	No	BA_3346	30257889		putative 6-aminohexanoate-dimer hydrolas...	419	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1WYB	26.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP90726
(show subtarget assignments)

8

purified

No

YPO1390

16121670

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

428

Predicted Essential

Community Requests

1G6S

80.1%

Yersinia pestis

IDP04447
(show subtarget assignments)

1

expressed

No

YPO0690

218927881

putative type II secretion protein [Yers...

428

putative drug target function;

Phase 4: April 2009

2OAP

26.6%

Yersinia pestis

Cell envelope

Surface structures

IDP02617
(show subtarget assignments)

1

expressed

No

GBAA1286

47526551

D-alanyl-D-alanine carboxypeptidase fami...

428

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3MFD

24.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05331
(show subtarget assignments)

1

soluble

No

SACOL0009

57651117

serS

seryl-tRNA synthetase [Staphylococcus au...

428

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2DQ3

51.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP02818
(show subtarget assignments)

1

selected

No

GBAA4027

47529320

pyrC

dihydroorotase [Bacillus anthracis str. ...

428

Conserved; Drug target functions

Phase 3: June 2008

3MPG

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0004

16763394

thrC

threonine synthase

428

Conserved Gene / Pathway

Phase 2: March 2008

1VB3

93.5%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP04208
(show subtarget assignments)

1

purified

No

CPF_2958

110799195

purA

adenylosuccinate synthetase [Clostridium...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1IWE

47.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00179
(show subtarget assignments)

1

cloned

No

YPO0277

16120616

-

putative transmembrane transport protein...

428

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP02337
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1511

47526786

gdhA

glutamate dehydrogenase [Bacillus anthra...

428

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K8Z

84.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP91529
(show subtarget assignments)

8

soluble

No

VC_1312

9655801

alanine racemase, putative [Vibrio chole...

428

other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...

Community Requests

4ECL

24.8%

Vibrio cholerae

IDP90730
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1598

15792903

hisD

histidinol dehydrogenase [Campylobacter ...

428

Predicted Essential

Community Requests

1K75

59.8%

Campylobacter jejuni

IDP92048
(show subtarget assignments)

8

selected

No

TGME49_049270

237835927

thioredoxin, putative [Toxoplasma gondii...

428

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3IDV

20.3%

Toxoplasma gondii

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04490
(show subtarget assignments)

1

in_pdb
3MJF

No

YPO3729

218930734

purD

phosphoribosylamine--glycine ligase [Yer...

428

conserved gene; putative drug target function;

Phase 4: April 2009

3MJF

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02484
(show subtarget assignments)

1

expressed

No

GBAA3922

47529214

zinc protease [Bacillus anthracis str. '...

428

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HDI

24.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01115
(show subtarget assignments)

1

in_pdb
3IG4

No

BA_1901

30256561

xaa-pro aminopeptidase, putative

427

Drug Target Function

Phase 2: March 2008

3IG4

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01016
(show subtarget assignments)

1

cloned

No

STM2792

16766103

gabT

4-aminobutyrate aminotransferase

427

Conserved Gene / Pathway

Phase 2: March 2008

1SF2

88.3%

Salmonella enterica

Central intermediary metabolism

Other

IDP05251
(show subtarget assignments)

1

cloned

No

lmo2747

16804784

serS

seryl-tRNA synthetase [Listeria monocyto...

427

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2DQ3

56.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP00946
(show subtarget assignments)

1

expressed

No

STM0978

16764338

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

427

Conserved Gene / Pathway

Phase 2: March 2008

1G6S

89.5%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00485
(show subtarget assignments)

1

purified

No

YPO1455

16121730

putative beta-ketoacyl-[acyl-carrier-pro...

427

Drug Target Function

Phase 2: March 2008

1J3N

32.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90968
(show subtarget assignments)

8

selected

No

427

Planet Biotechnology company is currently developing an anthrax anti-toxin with ...

Community Requests

1HZH

62.3%

synthetic construct

IDP90749
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1641

15792946

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

427

Predicted Essential

Community Requests

2WTZ

34.4%

Campylobacter jejuni

IDP05556
(show subtarget assignments)

1

soluble

No

lmo1521

16803561

-

hypothetical protein lmo1521 [Listeria m...

427

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3NE8

17.1%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01235
(show subtarget assignments)

1

purified

No

BA_5512

30259972

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

427

Drug Target Function

Phase 2: March 2008

3OJL

62.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90626
(show subtarget assignments)

8

in_pdb
3TI2
3NVS

No

VC1732

15641736

3-phosphoshikimate 1-carboxyvinyltransfe...

426

Predicted Essential

Community Requests

3NVS

100%

Vibrio cholerae

IDP90789
(show subtarget assignments)

8

in_pdb
4E77

No

YPO3389

16123538

hemL

glutamate-1-semialdehyde aminotransferas...

426

Predicted Essential

Community Requests

4E77

100%

Yersinia pestis

IDP04280
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1108

115346887

gltA

citrate synthase GltA [Yersinia pestis C...

426

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1K3P

86.6%

Yersinia pestis

Energy metabolism

TCA cycle

IDP01661
(show subtarget assignments)

1

soluble

No

GBAA4609

47529906

U32 family peptidase [Bacillus anthracis...

426

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90248
(show subtarget assignments)

8

purified

No

BAS0467

49183495

acetylornithine deacetylase [Bacillus an...

426

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3PFO

27%

Bacillus anthracis

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP05687
(show subtarget assignments)

1

cloned

No

lmo1520

16803560

hisS

histidyl-tRNA synthetase [Listeria monoc...

425

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1QE0

53.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05772
(show subtarget assignments)

1

cloned

No

Z3171

12516188

dacD

penicillin binding protein 6b [Escherich...

425

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZO

40.7%

Escherichia coli

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90803
(show subtarget assignments)

8

selected

No

YPO0055

16120408

kdtA

3-deoxy-D-manno-octulosonic-acid transfe...

425

Predicted Essential

Community Requests

2XCI

25.2%

Yersinia pestis

IDP02807
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4705

47530004

tig

trigger factor [Bacillus anthracis str. ...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T11

32.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP04632
(show subtarget assignments)

1

cloned

No

CBU_2005

29655288

rstB

signal transduction histidine kinase-lik...

425

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.2%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP91937
(show subtarget assignments)

8

selected

No

SpneCM_010100003555

298254676

ABC transporter membrane-spanning permea...

425

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP02200
(show subtarget assignments)

1

cloned

No

CBU_1103

29541677

transglycosylase, Slt family [Coxiella b...

425

Conserved; Drug target functions

Phase 3: June 2008

1QSA

16.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02315
(show subtarget assignments)

1

cloned

No

GBAA1132

47526402

aceA

isocitrate lyase [Bacillus anthracis str...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4E

71.4%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP04104
(show subtarget assignments)

1

expressed

No

YPO2309

115348012

rstB

two-component regulatory system, sensor ...

425

putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Yersinia pestis

Regulatory functions

Other

IDP90727
(show subtarget assignments)

8

cloned

No

Cj0853c

15792191

hemL

glutamate-1-semialdehyde aminotransferas...

424

Predicted Essential

Community Requests

3BS8

51.2%

Campylobacter jejuni

IDP04574
(show subtarget assignments)

1

soluble

No

BAS0015

49183051

seryl-tRNA synthetase [Bacillus anthraci...

424

Proposed to be essential proteins

Phase 4: April 2009

2DQ3

57.8%

Bacillus anthracis

IDP90816
(show subtarget assignments)

8

soluble

No

YPO2878

16123070

hisS

histidyl-tRNA synthetase [Yersinia pesti...

424

Predicted Essential

Community Requests

1KMM

82.1%

Yersinia pestis

IDP01721
(show subtarget assignments)

1

cloned

No

Cj1031

15792358

putative outer membrane component of eff...

424

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

2VDD

21.4%

Campylobacter jejuni

Regulatory functions

Other

IDP00795
(show subtarget assignments)

1

in_pdb
3GRI

No

SACOL1213

57285956

pyrC

dihydroorotase

424

Drug Target Function

Phase 2: March 2008

3GRI

100%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04686
(show subtarget assignments)

1

expressed

No

GBAA4223

47529516

kinB-3

sporulation kinase B [Bacillus anthracis...

424

putative drug target function;

Phase 4: April 2009

3D36

22.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04634
(show subtarget assignments)

1

in_pdb
3MSU

No

FTT0071c

56707250

gltA

citrate synthase [Francisella tularensis...

424

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3MSU

100%

Francisella tularensis

IDP00682
(show subtarget assignments)

1

cloned

No

SACOL1777

57286212

serine protease HtrA, putative

424

Drug Target Function

Phase 2: March 2008

2ZLE

29%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05228
(show subtarget assignments)

1

soluble

No

lmo0971

16803011

dltD

DltD protein for D-alanine esterificatio...

380

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3BMA

31.6%

Listeria monocytogenes

Cell envelope: Other

IDP00303
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0035

29653398

beta-ketoacyl synthase

424

Drug Target Function

Phase 2: March 2008

3E60

36.8%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02452
(show subtarget assignments)

1

purified

No

GBAA3312

47528597

diaminobutyrate--2-oxoglutarate aminotra...

424

Conserved; Essential; Drug target functions

Phase 3: June 2008

2EH6

31.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP92107
(show subtarget assignments)

8

selected

No

TGME49_091640

237838437

aspartate carbamoyltransferase [Toxoplas...

423

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1AT1

30.5%

Toxoplasma gondii

IDP00542
(show subtarget assignments)

1

cloned

No

YPO2744

16122948

fadL

long-chain fatty acid outer membrane tra...

423

Virulence Associated Factor

Phase 2: March 2008

1T16

64%

Yersinia pestis

Cell envelope

Other

IDP91960
(show subtarget assignments)

8

selected

No

SpneCM_010100008232

298255567

carbamate kinase [Streptococcus pneumoni...

423

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B7B

24.1%

Streptococcus pneumoniae

IDP02008
(show subtarget assignments)

1

in_crystallization_trials

No

STM3595

16766881

putative phosphatase [Salmonella typhimu...

423

Conserved; Drug target functions

Phase 3: June 2008

2A96

12.8%

Salmonella enterica

Central intermediary metabolism

Other

IDP01885
(show subtarget assignments)

1

cloned

No

GBAA5639

47530965

D-alanyl-D-alanine carboxypeptidase, put...

423

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02239
(show subtarget assignments)

1

expressed

No

GBAA0299

47525562

purD

phosphoribosylamine--glycine ligase [Bac...

423

Conserved; Drug target functions

Phase 3: June 2008

2YRW

64.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00359
(show subtarget assignments)

1

cloned

No

lmo2552

16804590

murZ

UDP-N-acetylglucosamine 1-carboxyvinyltr...

423

Drug Target Function

Phase 2: March 2008

3SG1

50.6%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02647
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0537

16802580

allantoate amidohydrolase [Listeria mono...

423

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3N5F

38.1%

Listeria monocytogenes

Energy metabolism

Amino acids and amines

IDP90854
(show subtarget assignments)

8

crystallized

No

Cj1727c

15793030

metY

putative O-acetylhomoserine (thiol)-lyas...

423

Predicted Essential

Community Requests

2CTZ

40.9%

Campylobacter jejuni

IDP90628
(show subtarget assignments)

8

in_crystallization_trials

No

VC0760

15640779

hisS

histidyl-tRNA synthetase [Vibrio cholera...

422

Predicted Essential

Community Requests

1KMM

74.5%

Vibrio cholerae

IDP02654
(show subtarget assignments)

1

cloned

No

Cj1682c

15792986

gltA

citrate synthase [Campylobacter jejuni s...

422

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

2H12

50.2%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP04281
(show subtarget assignments)

1

cloned

No

YPO1150

115346925

bioA

adenosylmethionine-8-amino-7-oxononanoat...

422

conserved gene; putative drug target function;

Phase 4: April 2009

1MLY

73.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP91684
(show subtarget assignments)

8

selected

No

NCAP_CVHSA

0

422

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SSK

32.9%

SARS coronavirus

IDP90776
(show subtarget assignments)

8

purified

No

STM2365

16765692

folC

bifunctional folylpolyglutamate synthase...

422

Predicted Essential

Community Requests

1W78

86.7%

Salmonella enterica

IDP00722
(show subtarget assignments)

1

purified

No

SACOL1667

57284680

peptidase, U32 family

422

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02143
(show subtarget assignments)

1

expressed

No

CBU_0739

29541339

clpX

ATP-dependent Clp protease, ATP-binding ...

422

Conserved; Drug target functions

Phase 3: June 2008

3HTE

59.5%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04679
(show subtarget assignments)

1

expressed

No

GBAA2644

47527936

kinB-2

sporulation kinase B [Bacillus anthracis...

422

putative drug target function;

Phase 4: April 2009

3D36

27.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP91364
(show subtarget assignments)

8

expressed

No

VV1_2716

27366006

Outer membrane protein [Vibrio vulnificu...

421

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1EK9

23.8%

Vibrio vulnificus

IDP01999
(show subtarget assignments)

1

soluble

No

FTT0942c

56708039

folK

2-amino-4-hydroxy-6-hydroxymethyldihydro...

421

Conserved; Drug target functions

Phase 3: June 2008

3MCM

99.1%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90985
(show subtarget assignments)

8

expressed

No

y0964

22124871

hypothetical protein y0964 [Yersinia pes...

421

other biological interest / -

Community Requests

3MVE

41.8%

Yersinia pestis

IDP90325
(show subtarget assignments)

8

cloned

No

CT089

15604808

lcrE

low calcium response E [Chlamydia tracho...

421

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2VJ4

13.3%

Chlamydia trachomatis

IDP00822
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2253

57285032

femX

femX protein

421

Conserved Gene / Pathway

Phase 2: March 2008

1LRZ

26.7%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00690
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2092

57284959

murAA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

421

Drug Target Function

Phase 2: March 2008

3SG1

64.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04322
(show subtarget assignments)

1

cloned

No

VC1001

15641016

folylpolyglutamate synthase/dihydrofolat...

421

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N2A

53.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00121
(show subtarget assignments)

1

in_pdb
3DQQ

No

NT01ST3629

16766223

ygbK

putative tRNA synthase

420

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DQQ

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02098
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0187

56707352

ftsA

cell division protein FtsA [Francisella ...

420

Conserved; Drug target functions

Phase 3: June 2008

1E4F

24%

Francisella tularensis

Cellular processes

Cell division

IDP04237
(show subtarget assignments)

1

purified

No

CPF_0863

110800564

putative sensor histidine kinase [Clostr...

420

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP01857
(show subtarget assignments)

1

soluble

No

FTT1034c

56708121

ndh

NADH dehydrogenase [Francisella tularens...

420

Drug Target

Phase 3: June 2008

1XHC

21%

Francisella tularensis

Energy metabolism

Electron transport

IDP05358
(show subtarget assignments)

1

cloned

No

BA_0685

30254284

conserved hypothetical protein [Bacillus...

420

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1I84

12.1%

Bacillus anthracis

Hypothetical proteins: Conserved

IDP00434
(show subtarget assignments)

1

cloned

No

YPO0796

16121108

lysA

diaminopimelate decarboxylase

420

Drug Target Function

Phase 2: March 2008

1KNW

76.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00425
(show subtarget assignments)

1

purified

No

YPO3863

16123998

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

420

Conserved Gene / Pathway

Phase 2: March 2008

3OJL

42.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05169
(show subtarget assignments)

1

soluble

No

BA_1952

30256610

NLP/P60 family protein [Bacillus anthrac...

420

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2F68

14%

Bacillus anthracis

Unknown function: General

IDP00702
(show subtarget assignments)

0

work_stopped

No

SACOL0150

57285353

cap5O

capsular polysaccharide biosynthesis pro...

420

Drug Target Function

Phase 2: March 2008

3OJL

98.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00680
(show subtarget assignments)

1

purified

No

SACOL1721

57284732

clpX

ATP-dependent protease ATP-binding subun...

420

Drug Target Function

Phase 2: March 2008

3HWS

52.4%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00594
(show subtarget assignments)

0

work_stopped

No

YPO3569

16123713

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

420

Conserved Gene / Pathway

Phase 2: March 2008

1NAW

91.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90936
(show subtarget assignments)

8

cloned

No

YPO2016

16122259

hemA

glutamyl-tRNA reductase [Yersinia pestis...

420

Predicted Essential

Community Requests

1GPJ

32.9%

Yersinia pestis

IDP91477
(show subtarget assignments)

8

expressed

No

VPA1338

28901193

putative ATPase YscN [Vibrio parahaemoly...

420

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2DPY

34.5%

Vibrio parahaemolyticus

IDP02478
(show subtarget assignments)

1

cloned

No

GBAA4182

47529478

pdhC

branched-chain alpha-keto acid dehydroge...

419

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

74.7%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP05533
(show subtarget assignments)

1

cloned

No

CD2149

126699765

hypothetical protein CD2149 [Clostridium...

419

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP91703
(show subtarget assignments)

8

selected

No

NP_003630

4504631

IKBKG

NF-kappa-B essential modulator isoform a...

419

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

3CL3

29.4%

Homo sapiens

IDP91625
(show subtarget assignments)

8

soluble

No

BAB35496

13361539

ECs2073

hypothetical protein [Escherichia coli O...

419

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3RG1

17.2%

Escherichia coli

IDP00112
(show subtarget assignments)

1

soluble

No

NT01SF5194

30043810

hflK

protease specific for phage lambda cII r...

419

Essential

Phase 1: October 2007

3BK6

11%

Shigella flexneri

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02006
(show subtarget assignments)

1

expressed

No

STM2285

16765612

glpB

anaerobic glycerol-3-phosphate dehydroge...

419

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Energy metabolism

Anaerobic

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04699
(show subtarget assignments)

1

expressed

No

YPCD1.53

16082741

yscD

virulence protein [Yersinia pestis CO92]...

419

virulence factor; conserved gene;

Phase 4: April 2009

4A0E

28.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01846
(show subtarget assignments)

1

soluble

No

CBU_1419

29541979

serine hydroxymethyltransferase [Coxiell...

419

Conserved; Drug target functions

Phase 3: June 2008

1DFO

68.5%

Coxiella burnetii

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP91544
(show subtarget assignments)

8

in_crystallization_trials

No

BAE54319

83627318

ereB

erythromycin esterase type II [Escherich...

419

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2QGM

25.8%

Escherichia coli

IDP91454
(show subtarget assignments)

8

cloned

No

VV1_0254

27363735

hemA

glutamyl-tRNA reductase [Vibrio vulnific...

419

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GPJ

36.3%

Vibrio vulnificus

IDP05595
(show subtarget assignments)

1

soluble

No

BA_3346

30257889

putative 6-aminohexanoate-dimer hydrolas...

419

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1WYB

26.3%

Bacillus anthracis

Central intermediary metabolism: Other