Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02271 (show subtarget assignments)	1	crystallized	No	FTT1155c	56708226	aroK	shikimate kinase I [Francisella tularens...	176	Conserved; Drug target functions	Phase 3: June 2008	1KAG	58%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP01312 (show subtarget assignments)	1	crystallized	No	VCA0819	15601574	groES	co-chaperonin GroES	96	Conserved Gene / Pathway	Phase 2: March 2008	1AON	65.6%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP05257 (show subtarget assignments)	1	crystallized	No	CD2748	126700363		putative transferase [Clostridium diffic...	165	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2EG0	48.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP01787 (show subtarget assignments)	1	crystallized	No	STM0332	16763712		putative hydrolase/acyltransferase [Salm...	304	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3QYJ	47.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01788 (show subtarget assignments)	1	crystallized	No	YPO3827	16123962	glpQ	glycerophosphodiester phosphodiesterase ...	371	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1YDY	71.7%	Yersinia pestis	Central intermediary metabolism	Other

IDP90908 (show subtarget assignments)	8	crystallized	No	STM1198	16764553	pabC	4-amino-4-deoxychorismate lyase [Salmone...	269	Predicted Essential	Community Requests	1ET0	69.9%	Salmonella enterica

IDP01802 (show subtarget assignments)	1	crystallized	No	FTT0062	56707241	atpA	F0F1 ATP synthase subunit alpha [Francis...	513	Conserved; Drug target functions	Phase 3: June 2008	3OAA	71%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02591 (show subtarget assignments)	1	crystallized	No	YPO3383	16123532	dgt	deoxyguanosinetriphosphate triphosphohyd...	506	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2PGS	29.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02509 (show subtarget assignments)	1	crystallized	No	STM1809	16765150		putative cytoplasmic protein [Salmonella...	57	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP90614 (show subtarget assignments)	8	crystallized	No	VC0013	15640045		DNA polymerase III subunit beta [Vibrio ...	366	Predicted Essential	Community Requests	1MMI	63.9%	Vibrio cholerae

IDP00054 (show subtarget assignments)	1	crystallized	No	BA_3600	30258128		acetyltransferase, CYSE/LACA/LPXA/NODL f...	185	Virulence	Phase 1: October 2007	1KHR	42.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02492 (show subtarget assignments)	1	crystallized	No	FTT1559c	56708586	proC	pyrroline-5-carboxylate reductase [Franc...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	37.6%	Francisella tularensis	Amino acid biosynthesis	Glutamate family

IDP90856 (show subtarget assignments)	8	crystallized	No	Cj0442	15791809	fabF	3-oxoacyl-(acyl carrier protein) synthas...	404	Predicted Essential	Community Requests	1J3N	52.7%	Campylobacter jejuni

IDP05243 (show subtarget assignments)	1	crystallized	No	lmo2198	16804237	trpS	tryptophanyl-tRNA synthetase [Listeria m...	331	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3PRH	72.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90854 (show subtarget assignments)	8	crystallized	No	Cj1727c	15793030	metY	putative O-acetylhomoserine (thiol)-lyas...	423	Predicted Essential	Community Requests	2CTZ	40.9%	Campylobacter jejuni

IDP90688 (show subtarget assignments)	8	crystallized	No	Cj1595	15792900	rpoA	DNA-directed RNA polymerase subunit alph...	337	Predicted Essential	Community Requests	3IYD	31.5%	Campylobacter jejuni

IDP05236 (show subtarget assignments)	1	crystallized	No	lmo1533	16803573	ruvA	hypothetical protein lmo1533 [Listeria m...	201	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	34.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP90617 (show subtarget assignments)	8	crystallized	No	YPO3927	16124057	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	334	Predicted Essential	Community Requests	2G17	78.1%	Yersinia pestis

IDP90834 (show subtarget assignments)	8	crystallized	No	VC1258	15641271		DNA gyrase, subunit A [Vibrio cholerae O...	894	Predicted Essential	Community Requests	3NUH	48.3%	Vibrio cholerae

IDP02466 (show subtarget assignments)	1	crystallized	No	YPO1771	16122025		L-serine dehydratase [Yersinia pestis CO...	454	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2IQQ	17%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00115 (show subtarget assignments)	1	crystallized	No	NT01VPA0514	28900406	VPA0551	hypothetical protein VPA0551 (gi 2890040...	181	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2OT9	33.7%	Vibrio parahaemolyticus	Cellular processes	Toxin production and resistance

IDP02456 (show subtarget assignments)	1	crystallized	No	GBAA3921	47529213	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	237	Conserved; Essential;	Phase 3: June 2008	2P68	38.1%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP00674 (show subtarget assignments)	1	crystallized	No	SACOL1453	57286104	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	25.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00668 (show subtarget assignments)	1	crystallized	No	SACOL1196	57284481	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	449	Conserved Gene / Pathway	Phase 2: March 2008	3LK7	46.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91802 (show subtarget assignments)	8	crystallized	No	lpg0123	52840378	dsbA	thiol:disulfide interchange protein DsbA...	217	virulence/pathogenesis / Legionella pneumophila is most closely related to Coxiella burnetti, the causati...	Community Requests	3L9S	27.6%	Legionella pneumophila

IDP00611 (show subtarget assignments)	1	crystallized	No	SACOL1952	57286299		ferritins family protein	166	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	39.2%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP00139 (show subtarget assignments)	1	crystallized	No	BA_4355	30258855	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1VKN	40.5%	Bacillus anthracis	Unknown function	General

IDP00595 (show subtarget assignments)	1	crystallized	No	YPO3760	16123897	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	345	Drug Target Function	Phase 2: March 2008	1MBB	60.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00925 (show subtarget assignments)	1	crystallized	No	STM0595	16763972	entC	isochorismate synthase	391	Drug Target Function	Phase 2: March 2008	3HWO	84.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP91794 (show subtarget assignments)	8	crystallized	No	BAA12910	1695688	mphB	macrolide 2'-phosphotransferase II [Esch...	302	other biological interest / Kinase	Community Requests	3TDW	18.5%	Escherichia coli

IDP91491 (show subtarget assignments)	8	crystallized	No	VP1692	28898466		putative type III export protein [Vibrio...	208	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP00776 (show subtarget assignments)	1	crystallized	No	SACOL0612	57285627		glycosyl transferase, group 1 family pro...	496	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	11.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00788 (show subtarget assignments)	1	crystallized	No	SACOL1043	57284414		glycosyl transferase, group 1 family pro...	493	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	16.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90686 (show subtarget assignments)	8	crystallized	No	Cj0918c	15792247	prsA	ribose-phosphate pyrophosphokinase [Camp...	309	Predicted Essential	Community Requests	3DAH	57.1%	Campylobacter jejuni

IDP00016 (show subtarget assignments)	1	crystallized	No	BA_4053	46576983		UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	491	Drug Target Homolog	Phase 1: October 2007	2WTZ	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91470 (show subtarget assignments)	8	crystallized	No	VPA1355	28901210		putative type III secretion system EscV ...	627	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP00877 (show subtarget assignments)	1	crystallized	No	STM3015	16766317	ygeA	putative racemase	235	Conserved Gene / Pathway	Phase 2: March 2008	3OJC	56.6%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01344 (show subtarget assignments)	1	crystallized	No	VCA1025	15601778	nagB	glucosamine-6-phosphate deaminase	266	Drug Target Function	Phase 2: March 2008	1CD5	79.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP00943 (show subtarget assignments)	1	crystallized	No	STM0862	16764224	yliJ	putative glutathione S-transferase	208	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	30.8%	Salmonella enterica	Cellular processes	Detoxification

IDP00944 (show subtarget assignments)	1	crystallized	No	STM0891	16764252	artP	arginine transporter ATP-binding subunit...	242	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	43.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP91762 (show subtarget assignments)	8	crystallized	No	CAC99716	16411074	lmo1638	lmo1638 [Listeria monocytogenes EGD-e]	324	drug resistance; innate immunity / Listeria monocytogenes MccF-like (MccF homolog) - E.coli MccF confers immunity t...	Community Requests	4E5S	55.8%	Listeria monocytogenes

IDP02226 (show subtarget assignments)	1	crystallized	No	GBAA0164	47525422	yqjI	6-phosphogluconate dehydrogenase [Bacill...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2W8Z	72.3%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP90514 (show subtarget assignments)	8	crystallized	No	Cj0513	15791875		phosphoribosylformylglycinamidine syntha...	81	Predicted Essential	Community Requests	1T4A	46.9%	Campylobacter jejuni

IDP02222 (show subtarget assignments)	1	crystallized	No	lmo0484	16802527		heme-degrading monooxygenase IsdG [Liste...	121	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1TZ0	28.9%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP02406 (show subtarget assignments)	1	crystallized	No	GBAA2768	47528059		thioredoxin reductase, putative [Bacillu...	301	Conserved; Essential; Drug target functions	Phase 3: June 2008	3FBS	32.1%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02026 (show subtarget assignments)	1	crystallized	No	CBU_0123	29540743	murE	UDP-N-acetylmuramoylalanyl-D-glutamate-2...	489	Conserved; Drug target functions	Phase 3: June 2008	1E8C	41.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01406 (show subtarget assignments)	1	crystallized	No	VC0918	15640934	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	413	Conserved Gene / Pathway	Phase 2: March 2008	3OJL	45.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00154 (show subtarget assignments)	1	crystallized	No	VC2448	15642444	pyrG	CTP synthase	545	Essential	Phase 1: October 2007	1S1M	79.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90003 (show subtarget assignments)	8	crystallized	No	FTT1103	56708183		conserved hypothetical lipoprotein	365	(Community Request)	Community Requests	3GYK	12.3%	Francisella tularensis

IDP91396 (show subtarget assignments)	8	crystallized	No	VV1_1047	27364479	fmt	methionyl-tRNA formyltransferase [Vibrio...	315	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3Q0I	83.2%	Vibrio vulnificus

IDP01866 (show subtarget assignments)	1	crystallized	No	FTT1772c	56708766	trpA	tryptophan synthase subunit alpha [Franc...	269	Drug Target	Phase 3: June 2008	3NAV	61%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00102 (show subtarget assignments)	1	crystallized	No	NT01SF2944	30042031	evgA	putative positive transcription regulato...	204	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3F6C	64.7%	Shigella flexneri	Cell envelope	Surface structures

IDP90635 (show subtarget assignments)	8	crystallized	No	VC1483	15641492		3-hydroxydecanoyl-(acyl carrier protein)...	172	Predicted Essential	Community Requests	1MKA	77.9%	Vibrio cholerae

IDP90753 (show subtarget assignments)	8	crystallized	No	Cj0586	15791946	ligA	NAD-dependent DNA ligase LigA [Campyloba...	647	Predicted Essential	Community Requests	2OWO	40.7%	Campylobacter jejuni

IDP04731 (show subtarget assignments)	1	crystallized	No	BAS3675	49186674		ribosome recycling factor [Bacillus anth...	185	Proposed to be essential proteins	Phase 4: April 2009	1IS1	50.8%	Bacillus anthracis

IDP90256 (show subtarget assignments)	8	crystallized	No	SAR0409	49482642	guaA	bifunctional GMP synthase/glutamine amid...	513	(From requestor) Identified potential S. aureus drug target. Would like to devel...	Community Requests	1GPM	51.2%	Staphylococcus aureus

IDP01436 (show subtarget assignments)	1	crystallized	No	VC1976	15641978		menaquinone-specific isochorismate synth...	435	Drug Target Function	Phase 2: March 2008	3GSE	42.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02020 (show subtarget assignments)	1	crystallized	No	FTT0245	56707402	usp	universal stress protein [Francisella tu...	278	Drug Target	Phase 3: June 2008	2PFS	20.5%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP01877 (show subtarget assignments)	1	crystallized	No	GBAA0080	47525336		negative regulator of genetic competence...	811	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PXI	80.1%	Bacillus anthracis	Cellular processes	DNA transformation

IDP01439 (show subtarget assignments)	1	crystallized	No	VC2019	15642021		3-oxoacyl-(acyl carrier protein) synthas...	414	Drug Target Function	Phase 2: March 2008	1B3N	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90806 (show subtarget assignments)	8	crystallized	No	S0665	30062173	phpB	alpha-ribazole phosphatase [Shigella fle...	203	Predicted Essential	Community Requests	3HJG	28.4%	Shigella flexneri

IDP00323 (show subtarget assignments)	1	crystallized	No	Cj0858c	15792196	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	418	Drug Target Function	Phase 2: March 2008	1NAW	49%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP90526 (show subtarget assignments)	8	crystallized	No	YPO1106	16121406	ppnK	inorganic polyphosphate/ATP-NAD kinase [...	293	Predicted Essential	Community Requests	2AN1	83.6%	Yersinia pestis

IDP00325 (show subtarget assignments)	1	crystallized	No	Cj1530	15792838	coaE	dephospho-CoA kinase	201	Drug Target Function	Phase 2: March 2008	2IF2	32.8%	Campylobacter jejuni	Unclassified	Unclassified

IDP05631 (show subtarget assignments)	1	crystallized	No	CD1979	126699588		ABC transporter, substrate-binding prote...	337	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	26.4%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP01055 (show subtarget assignments)	1	crystallized	No	STM3371	16766666	maf	Maf-like protein	197	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	43.7%	Salmonella enterica	Cellular processes	Cell division

IDP04573 (show subtarget assignments)	1	crystallized	No	BAS0006	49183045		DNA gyrase subunit A [Bacillus anthracis...	823	Proposed to be essential proteins	Phase 4: April 2009	2XCO	42.9%	Bacillus anthracis

IDP01923 (show subtarget assignments)	1	crystallized	No	STM1595	16764939	srfC	putative virulence protein [Salmonella t...	714	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP90742 (show subtarget assignments)	8	crystallized	No	Cj0947c	15792276		hydrolase, carbon-nitrogen family [Campy...	290	Predicted Essential	Community Requests	3IVZ	34.1%	Campylobacter jejuni

IDP04529 (show subtarget assignments)	1	crystallized	No	STM2481_1_1037	16765801	acrD	aminoglycoside/multidrug efflux system [...	1037	Salmonella essential protein	Phase 4: April 2009	1IWG	66.2%	Salmonella enterica

IDP00333 (show subtarget assignments)	1	crystallized	No	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04507 (show subtarget assignments)	1	crystallized	No	VCA1079	9658525		pyridoxamine 5`-phosphate oxidase [Vibri...	211	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1G76	65.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04500 (show subtarget assignments)	1	crystallized	No	VC0986	15641001	adk	adenylate kinase [Vibrio cholerae O1 bio...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AKE	73.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04461 (show subtarget assignments)	1	crystallized	No	YPO1587	218928723	pyrC	dihydroorotase [Yersinia pestis CO92]	348	conserved gene; putative drug target function;	Phase 4: April 2009	3IHN	72.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01060 (show subtarget assignments)	1	crystallized	No	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01516 (show subtarget assignments)	1	crystallized	No	VC0576	15640598	sspA	stringent starvation protein A	211	Conserved Gene / Pathway	Phase 2: March 2008	1YY7	73.9%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP01604 (show subtarget assignments)	1	crystallized	No	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	3QF4	25.6%	Coxiella burnetii	Transport and binding proteins	Other

IDP01609 (show subtarget assignments)	1	crystallized	No	FTT1512c	56708550	dnaJ1	heat shock protein, hsp40 [Francisella t...	308	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	34.2%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01118 (show subtarget assignments)	1	crystallized	No	BA_4030	81837831		Bifunctional protein pyrR [Includes: Pyr...	180	Conserved Gene / Pathway	Phase 2: March 2008	1A3C	73.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02296 (show subtarget assignments)	1	crystallized	No	GBAA0020	47525275		hypothetical protein GBAA0020 [Bacillus ...	109	Conserved; Involved in sporulation;	Phase 3: June 2008	1YBX	55.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01141 (show subtarget assignments)	1	crystallized	No	BA_5155	56404588		Probable cytosol aminopeptidase (Leucine...	494	Drug Target Function	Phase 2: March 2008	3H8E	38.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90539 (show subtarget assignments)	8	crystallized	No	VC2708	15642702	gmk	guanylate kinase [Vibrio cholerae O1 bio...	229	Predicted Essential	Community Requests	1S96	59.8%	Vibrio cholerae

IDP90678 (show subtarget assignments)	8	crystallized	No	Cj0766c	15792104	tdk	thymidylate kinase [Campylobacter jejuni...	192	Predicted Essential	Community Requests	3HJN	33.8%	Campylobacter jejuni

IDP90541 (show subtarget assignments)	8	crystallized	No	VC0297	15640325		3-dehydroquinate dehydratase [Vibrio cho...	150	Predicted Essential	Community Requests	3LWZ	70.7%	Vibrio cholerae

IDP90729 (show subtarget assignments)	8	crystallized	No	Cj0572	15791932	ribA	bifunctional 3,4-dihydroxy-2-butanone 4-...	339	Predicted Essential	Community Requests	3MGZ	29.5%	Campylobacter jejuni

IDP00141 (show subtarget assignments)	1	crystallized	No	VC0401	15640428	mshK	MSHA biogenesis protein MshK	105	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP04376 (show subtarget assignments)	1	crystallized	No	CPF_2558	110800169	guaB	inositol-5-monophosphate dehydrogenase [...	484	conserved gene; putative drug target function;	Phase 4: April 2009	3TSB	67.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04374 (show subtarget assignments)	1	crystallized	No	YPO3501	218930515	folP	dihydropteroate synthase [Yersinia pesti...	277	conserved gene; putative drug target function;	Phase 4: April 2009	3TYU	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90677 (show subtarget assignments)	8	crystallized	No	Cj0702	15792051	purE	phosphoribosylaminoimidazole carboxylase...	164	Predicted Essential	Community Requests	3TRH	53.7%	Campylobacter jejuni

IDP04364 (show subtarget assignments)	1	crystallized	No	VC0767	15640786		inositol-5-monophosphate dehydrogenase [...	489	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3TSB	56.6%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90278 (show subtarget assignments)	8	crystallized	No	TGME49_003450	211965291		hypothetical protein, conserved [Toxopla...	227	Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...	Community Requests	2PD0	41.9%	Toxoplasma gondii

IDP01637 (show subtarget assignments)	1	crystallized	No	GBAA5111	47530413	menD	2-succinyl-6-hydroxy-2,4-cyclohexadiene-...	584	Conserved; Drug target functions	Phase 3: June 2008	2X7J	46.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90547 (show subtarget assignments)	8	crystallized	No	Cj1601	15792906	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	243	Predicted Essential	Community Requests	2X30	33.7%	Campylobacter jejuni

IDP02279 (show subtarget assignments)	1	crystallized	No	FTT1164c	56708234	era	GTP-binding protein Era [Francisella tul...	297	Drug Target	Phase 3: June 2008	1EGA	48.5%	Francisella tularensis	Cellular processesRegulatory functions	Cell divisionRNA interactions

IDP02431 (show subtarget assignments)	1	crystallized	No	CBU_1770	29542327		ABC transporter, ATP-binding protein [Co...	432	Conserved; Drug target functions	Phase 3: June 2008	2YYZ	23.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01643 (show subtarget assignments)	1	crystallized	No	YPO2892	16123083	hscA	chaperone protein HscA [Yersinia pestis ...	650	CD; Drug target functions	Phase 3: June 2008	2KHO	37.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP91216 (show subtarget assignments)	1	crystallized	No	FTT_1275	56708335	mglA	macrophage growth locus, subunit A [Fran...	205	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MDK	25.4%	Francisella tularensis

IDP05606 (show subtarget assignments)	1	crystal_structure	No	BA_4837	30259338	mdh	malate dehydrogenase [Bacillus anthracis...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TL2	100%	Bacillus anthracis	Energy metabolism: TCA cycle

IDP04136 (show subtarget assignments)	1	diffraction	No	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04174 (show subtarget assignments)	1	diffraction	No	VC2508	15642504		ornithine carbamoyltransferase [Vibrio c...	334	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3UPD	82.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP02271
(show subtarget assignments)

1

crystallized

No

FTT1155c

56708226

aroK

shikimate kinase I [Francisella tularens...

176

Conserved; Drug target functions

Phase 3: June 2008

1KAG

58%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP01312
(show subtarget assignments)

1

crystallized

No

VCA0819

15601574

groES

co-chaperonin GroES

96

Conserved Gene / Pathway

Phase 2: March 2008

1AON

65.6%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP05257
(show subtarget assignments)

1

crystallized

No

CD2748

126700363

putative transferase [Clostridium diffic...

165

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2EG0

48.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP01787
(show subtarget assignments)

1

crystallized

No

STM0332

16763712

putative hydrolase/acyltransferase [Salm...

304

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3QYJ

47.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01788
(show subtarget assignments)

1

crystallized

No

YPO3827

16123962

glpQ

glycerophosphodiester phosphodiesterase ...

371

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1YDY

71.7%

Yersinia pestis

Central intermediary metabolism

Other

IDP90908
(show subtarget assignments)

8

crystallized

No

STM1198

16764553

pabC

4-amino-4-deoxychorismate lyase [Salmone...

269

Predicted Essential

Community Requests

1ET0

69.9%

Salmonella enterica

IDP01802
(show subtarget assignments)

1

crystallized

No

FTT0062

56707241

atpA

F0F1 ATP synthase subunit alpha [Francis...

513

Conserved; Drug target functions

Phase 3: June 2008

3OAA

71%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02591
(show subtarget assignments)

1

crystallized

No

YPO3383

16123532

dgt

deoxyguanosinetriphosphate triphosphohyd...

506

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2PGS

29.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02509
(show subtarget assignments)

1

crystallized

No

STM1809

16765150

putative cytoplasmic protein [Salmonella...

57

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP90614
(show subtarget assignments)

8

crystallized

No

VC0013

15640045

DNA polymerase III subunit beta [Vibrio ...

366

Predicted Essential

Community Requests

1MMI

63.9%

Vibrio cholerae

IDP00054
(show subtarget assignments)

1

crystallized

No

BA_3600

30258128

acetyltransferase, CYSE/LACA/LPXA/NODL f...

185

Virulence

Phase 1: October 2007

1KHR

42.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02492
(show subtarget assignments)

1

crystallized

No

FTT1559c

56708586

proC

pyrroline-5-carboxylate reductase [Franc...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

37.6%

Francisella tularensis

Amino acid biosynthesis

Glutamate family

IDP90856
(show subtarget assignments)

8

crystallized

No

Cj0442

15791809

fabF

3-oxoacyl-(acyl carrier protein) synthas...

404

Predicted Essential

Community Requests

1J3N

52.7%

Campylobacter jejuni

IDP05243
(show subtarget assignments)

1

crystallized

No

lmo2198

16804237

trpS

tryptophanyl-tRNA synthetase [Listeria m...

331

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3PRH

72.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90854
(show subtarget assignments)

8

crystallized

No

Cj1727c

15793030

metY

putative O-acetylhomoserine (thiol)-lyas...

423

Predicted Essential

Community Requests

2CTZ

40.9%

Campylobacter jejuni

IDP90688
(show subtarget assignments)

8

crystallized

No

Cj1595

15792900

rpoA

DNA-directed RNA polymerase subunit alph...

337

Predicted Essential

Community Requests

3IYD

31.5%

Campylobacter jejuni

IDP05236
(show subtarget assignments)

1

crystallized

No

lmo1533

16803573

ruvA

hypothetical protein lmo1533 [Listeria m...

201

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

34.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP90617
(show subtarget assignments)

8

crystallized

No

YPO3927

16124057

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

334

Predicted Essential

Community Requests

2G17

78.1%

Yersinia pestis

IDP90834
(show subtarget assignments)

8

crystallized

No

VC1258

15641271

DNA gyrase, subunit A [Vibrio cholerae O...

894

Predicted Essential

Community Requests

3NUH

48.3%

Vibrio cholerae

IDP02466
(show subtarget assignments)

1

crystallized

No

YPO1771

16122025

L-serine dehydratase [Yersinia pestis CO...

454

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2IQQ

17%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00115
(show subtarget assignments)

1

crystallized

No

NT01VPA0514

28900406

VPA0551

hypothetical protein VPA0551 (gi 2890040...

181

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2OT9

33.7%

Vibrio parahaemolyticus

Cellular processes

Toxin production and resistance

IDP02456
(show subtarget assignments)

1

crystallized

No

GBAA3921

47529213

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

237

Conserved; Essential;

Phase 3: June 2008

2P68

38.1%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP00674
(show subtarget assignments)

1

crystallized

No

SACOL1453

57286104

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

25.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00668
(show subtarget assignments)

1

crystallized

No

SACOL1196

57284481

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

449

Conserved Gene / Pathway

Phase 2: March 2008

3LK7

46.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91802
(show subtarget assignments)

8

crystallized

No

lpg0123

52840378

dsbA

thiol:disulfide interchange protein DsbA...

217

virulence/pathogenesis / Legionella pneumophila is most closely related to Coxiella burnetti, the causati...

Community Requests

3L9S

27.6%

Legionella pneumophila

IDP00611
(show subtarget assignments)

1

crystallized

No

SACOL1952

57286299

ferritins family protein

166

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

39.2%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP00139
(show subtarget assignments)

1

crystallized

No

BA_4355

30258855

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1VKN

40.5%

Bacillus anthracis

Unknown function

General

IDP00595
(show subtarget assignments)

1

crystallized

No

YPO3760

16123897

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

345

Drug Target Function

Phase 2: March 2008

1MBB

60.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00925
(show subtarget assignments)

1

crystallized

No

STM0595

16763972

entC

isochorismate synthase

391

Drug Target Function

Phase 2: March 2008

3HWO

84.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP91794
(show subtarget assignments)

8

crystallized

No

BAA12910

1695688

mphB

macrolide 2'-phosphotransferase II [Esch...

302

other biological interest / Kinase

Community Requests

3TDW

18.5%

Escherichia coli

IDP91491
(show subtarget assignments)

8

crystallized

No

VP1692

28898466

putative type III export protein [Vibrio...

208

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP00776
(show subtarget assignments)

1

crystallized

No

SACOL0612

57285627

glycosyl transferase, group 1 family pro...

496

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

11.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00788
(show subtarget assignments)

1

crystallized

No

SACOL1043

57284414

glycosyl transferase, group 1 family pro...

493

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

16.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90686
(show subtarget assignments)

8

crystallized

No

Cj0918c

15792247

prsA

ribose-phosphate pyrophosphokinase [Camp...

309

Predicted Essential

Community Requests

3DAH

57.1%

Campylobacter jejuni

IDP00016
(show subtarget assignments)

1

crystallized

No

BA_4053

46576983

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

491

Drug Target Homolog

Phase 1: October 2007

2WTZ

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91470
(show subtarget assignments)

8

crystallized

No

VPA1355

28901210

putative type III secretion system EscV ...

627

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP00877
(show subtarget assignments)

1

crystallized

No

STM3015

16766317

ygeA

putative racemase

235

Conserved Gene / Pathway

Phase 2: March 2008

3OJC

56.6%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01344
(show subtarget assignments)

1

crystallized

No

VCA1025

15601778

nagB

glucosamine-6-phosphate deaminase

266

Drug Target Function

Phase 2: March 2008

1CD5

79.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP00943
(show subtarget assignments)

1

crystallized

No

STM0862

16764224

yliJ

putative glutathione S-transferase

208

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

30.8%

Salmonella enterica

Cellular processes

Detoxification

IDP00944
(show subtarget assignments)

1

crystallized

No

STM0891

16764252

artP

arginine transporter ATP-binding subunit...

242

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

43.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP91762
(show subtarget assignments)

8

crystallized

No

CAC99716

16411074

lmo1638

lmo1638 [Listeria monocytogenes EGD-e]

324

drug resistance; innate immunity / Listeria monocytogenes MccF-like (MccF homolog) - E.coli MccF confers immunity t...

Community Requests

4E5S

55.8%

Listeria monocytogenes

IDP02226
(show subtarget assignments)

1

crystallized

No

GBAA0164

47525422

yqjI

6-phosphogluconate dehydrogenase [Bacill...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2W8Z

72.3%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP90514
(show subtarget assignments)

8

crystallized

No

Cj0513

15791875

phosphoribosylformylglycinamidine syntha...

81

Predicted Essential

Community Requests

1T4A

46.9%

Campylobacter jejuni

IDP02222
(show subtarget assignments)

1

crystallized

No

lmo0484

16802527

heme-degrading monooxygenase IsdG [Liste...

121

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1TZ0

28.9%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP02406
(show subtarget assignments)

1

crystallized

No

GBAA2768

47528059

thioredoxin reductase, putative [Bacillu...

301

Conserved; Essential; Drug target functions

Phase 3: June 2008

3FBS

32.1%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02026
(show subtarget assignments)

1

crystallized

No

CBU_0123

29540743

murE

UDP-N-acetylmuramoylalanyl-D-glutamate-2...

489

Conserved; Drug target functions

Phase 3: June 2008

1E8C

41.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01406
(show subtarget assignments)

1

crystallized

No

VC0918

15640934

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

413

Conserved Gene / Pathway

Phase 2: March 2008

3OJL

45.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00154
(show subtarget assignments)

1

crystallized

No

VC2448

15642444

pyrG

CTP synthase

545

Essential

Phase 1: October 2007

1S1M

79.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90003
(show subtarget assignments)

8

crystallized

No

FTT1103

56708183

conserved hypothetical lipoprotein

365

(Community Request)

Community Requests

3GYK

12.3%

Francisella tularensis

IDP91396
(show subtarget assignments)

8

crystallized

No

VV1_1047

27364479

fmt

methionyl-tRNA formyltransferase [Vibrio...

315

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3Q0I

83.2%

Vibrio vulnificus

IDP01866
(show subtarget assignments)

1

crystallized

No

FTT1772c

56708766

trpA

tryptophan synthase subunit alpha [Franc...

269

Drug Target

Phase 3: June 2008

3NAV

61%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00102
(show subtarget assignments)

1

crystallized

No

NT01SF2944

30042031

evgA

putative positive transcription regulato...

204

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3F6C

64.7%

Shigella flexneri

Cell envelope

Surface structures

IDP90635
(show subtarget assignments)

8

crystallized

No

VC1483

15641492

3-hydroxydecanoyl-(acyl carrier protein)...

172

Predicted Essential

Community Requests

1MKA

77.9%

Vibrio cholerae

IDP90753
(show subtarget assignments)

8

crystallized

No

Cj0586

15791946

ligA

NAD-dependent DNA ligase LigA [Campyloba...

647

Predicted Essential

Community Requests

2OWO

40.7%

Campylobacter jejuni

IDP04731
(show subtarget assignments)

1

crystallized

No

BAS3675

49186674

ribosome recycling factor [Bacillus anth...

185

Proposed to be essential proteins

Phase 4: April 2009

1IS1

50.8%

Bacillus anthracis

IDP90256
(show subtarget assignments)

8

crystallized

No

SAR0409

49482642

guaA

bifunctional GMP synthase/glutamine amid...

513

(From requestor) Identified potential S. aureus drug target. Would like to devel...

Community Requests

1GPM

51.2%

Staphylococcus aureus

IDP01436
(show subtarget assignments)

1

crystallized

No

VC1976

15641978

menaquinone-specific isochorismate synth...

435

Drug Target Function

Phase 2: March 2008

3GSE

42.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02020
(show subtarget assignments)

1

crystallized

No

FTT0245

56707402

usp

universal stress protein [Francisella tu...

278

Drug Target

Phase 3: June 2008

2PFS

20.5%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP01877
(show subtarget assignments)

1

crystallized

No

GBAA0080

47525336

negative regulator of genetic competence...

811

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PXI

80.1%

Bacillus anthracis

Cellular processes

DNA transformation

IDP01439
(show subtarget assignments)

1

crystallized

No

VC2019

15642021

3-oxoacyl-(acyl carrier protein) synthas...

414

Drug Target Function

Phase 2: March 2008

1B3N

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90806
(show subtarget assignments)

8

crystallized

No

S0665

30062173

phpB

alpha-ribazole phosphatase [Shigella fle...

203

Predicted Essential

Community Requests

3HJG

28.4%

Shigella flexneri

IDP00323
(show subtarget assignments)

1

crystallized

No

Cj0858c

15792196

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

418

Drug Target Function

Phase 2: March 2008

1NAW

49%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP90526
(show subtarget assignments)

8

crystallized

No

YPO1106

16121406

ppnK

inorganic polyphosphate/ATP-NAD kinase [...

293

Predicted Essential

Community Requests

2AN1

83.6%

Yersinia pestis

IDP00325
(show subtarget assignments)

1

crystallized

No

Cj1530

15792838

coaE

dephospho-CoA kinase

201

Drug Target Function

Phase 2: March 2008

2IF2

32.8%

Campylobacter jejuni

Unclassified

IDP05631
(show subtarget assignments)

1

crystallized

No

CD1979

126699588

ABC transporter, substrate-binding prote...

337

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

26.4%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP01055
(show subtarget assignments)

1

crystallized

No

STM3371

16766666

maf

Maf-like protein

197

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

43.7%

Salmonella enterica

Cellular processes

Cell division

IDP04573
(show subtarget assignments)

1

crystallized

No

BAS0006

49183045

DNA gyrase subunit A [Bacillus anthracis...

823

Proposed to be essential proteins

Phase 4: April 2009

2XCO

42.9%

Bacillus anthracis

IDP01923
(show subtarget assignments)

1

crystallized

No

STM1595

16764939

srfC

putative virulence protein [Salmonella t...

714

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP90742
(show subtarget assignments)

8

crystallized

No

Cj0947c

15792276

hydrolase, carbon-nitrogen family [Campy...

290

Predicted Essential

Community Requests

3IVZ

34.1%

Campylobacter jejuni

IDP04529
(show subtarget assignments)

1

crystallized

No

STM2481_1_1037

16765801

acrD

aminoglycoside/multidrug efflux system [...

1037

Salmonella essential protein

Phase 4: April 2009

1IWG

66.2%

Salmonella enterica

IDP00333
(show subtarget assignments)

1

crystallized

No

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04507
(show subtarget assignments)

1

crystallized

No

VCA1079

9658525

pyridoxamine 5`-phosphate oxidase [Vibri...

211

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1G76

65.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP04500
(show subtarget assignments)

1

crystallized

No

VC0986

15641001

adk

adenylate kinase [Vibrio cholerae O1 bio...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AKE

73.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04461
(show subtarget assignments)

1

crystallized

No

YPO1587

218928723

pyrC

dihydroorotase [Yersinia pestis CO92]

348

conserved gene; putative drug target function;

Phase 4: April 2009

3IHN

72.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01060
(show subtarget assignments)

1

crystallized

No

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01516
(show subtarget assignments)

1

crystallized

No

VC0576

15640598

sspA

stringent starvation protein A

211

Conserved Gene / Pathway

Phase 2: March 2008

1YY7

73.9%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP01604
(show subtarget assignments)

1

crystallized

No

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

3QF4

25.6%

Coxiella burnetii

Transport and binding proteins

Other

IDP01609
(show subtarget assignments)

1

crystallized

No

FTT1512c

56708550

dnaJ1

heat shock protein, hsp40 [Francisella t...

308

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

34.2%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01118
(show subtarget assignments)

1

crystallized

No

BA_4030

81837831

Bifunctional protein pyrR [Includes: Pyr...

180

Conserved Gene / Pathway

Phase 2: March 2008

1A3C

73.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02296
(show subtarget assignments)

1

crystallized

No

GBAA0020

47525275

hypothetical protein GBAA0020 [Bacillus ...

109

Conserved; Involved in sporulation;

Phase 3: June 2008

1YBX

55.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01141
(show subtarget assignments)

1

crystallized

No

BA_5155

56404588

Probable cytosol aminopeptidase (Leucine...

494

Drug Target Function

Phase 2: March 2008

3H8E

38.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90539
(show subtarget assignments)

8

crystallized

No

VC2708

15642702

gmk

guanylate kinase [Vibrio cholerae O1 bio...

229

Predicted Essential

Community Requests

1S96

59.8%

Vibrio cholerae

IDP90678
(show subtarget assignments)

8

crystallized

No

Cj0766c

15792104

tdk

thymidylate kinase [Campylobacter jejuni...

192

Predicted Essential

Community Requests

3HJN

33.8%

Campylobacter jejuni

IDP90541
(show subtarget assignments)

8

crystallized

No

VC0297

15640325

3-dehydroquinate dehydratase [Vibrio cho...

150

Predicted Essential

Community Requests

3LWZ

70.7%

Vibrio cholerae

IDP90729
(show subtarget assignments)

8

crystallized

No

Cj0572

15791932

ribA

bifunctional 3,4-dihydroxy-2-butanone 4-...

339

Predicted Essential

Community Requests

3MGZ

29.5%

Campylobacter jejuni

IDP00141
(show subtarget assignments)

1

crystallized

No

VC0401

15640428

mshK

MSHA biogenesis protein MshK

105

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP04376
(show subtarget assignments)

1

crystallized

No

CPF_2558

110800169

guaB

inositol-5-monophosphate dehydrogenase [...

484

conserved gene; putative drug target function;

Phase 4: April 2009

3TSB

67.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04374
(show subtarget assignments)

1

crystallized

No

YPO3501

218930515

folP

dihydropteroate synthase [Yersinia pesti...

277

conserved gene; putative drug target function;

Phase 4: April 2009

3TYU

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90677
(show subtarget assignments)

8

crystallized

No

Cj0702

15792051

purE

phosphoribosylaminoimidazole carboxylase...

164

Predicted Essential

Community Requests

3TRH

53.7%

Campylobacter jejuni

IDP04364
(show subtarget assignments)

1

crystallized

No

VC0767

15640786

inositol-5-monophosphate dehydrogenase [...

489

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3TSB

56.6%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90278
(show subtarget assignments)

8

crystallized

No

TGME49_003450

211965291

hypothetical protein, conserved [Toxopla...

227

Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...

Community Requests

2PD0

41.9%

Toxoplasma gondii

IDP01637
(show subtarget assignments)

1

crystallized

No

GBAA5111

47530413

menD

2-succinyl-6-hydroxy-2,4-cyclohexadiene-...

584

Conserved; Drug target functions

Phase 3: June 2008

2X7J

46.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90547
(show subtarget assignments)

8

crystallized

No

Cj1601

15792906

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

243

Predicted Essential

Community Requests

2X30

33.7%

Campylobacter jejuni

IDP02279
(show subtarget assignments)

1

crystallized

No

FTT1164c

56708234

era

GTP-binding protein Era [Francisella tul...

297

Drug Target

Phase 3: June 2008

1EGA

48.5%

Francisella tularensis

Cellular processesRegulatory functions

Cell divisionRNA interactions

IDP02431
(show subtarget assignments)

1

crystallized

No

CBU_1770

29542327

ABC transporter, ATP-binding protein [Co...

432

Conserved; Drug target functions

Phase 3: June 2008

2YYZ

23.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01643
(show subtarget assignments)

1

crystallized

No

YPO2892

16123083

hscA

chaperone protein HscA [Yersinia pestis ...

650

CD; Drug target functions

Phase 3: June 2008

2KHO

37.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP91216
(show subtarget assignments)

1

crystallized

No

FTT_1275

56708335

mglA

macrophage growth locus, subunit A [Fran...

205

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MDK

25.4%

Francisella tularensis

IDP05606
(show subtarget assignments)

1

crystal_structure

No

BA_4837

30259338

mdh

malate dehydrogenase [Bacillus anthracis...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TL2

100%

Bacillus anthracis

Energy metabolism: TCA cycle

IDP04136
(show subtarget assignments)

1

diffraction

No

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04174
(show subtarget assignments)

1

diffraction

No

VC2508

15642504

ornithine carbamoyltransferase [Vibrio c...

334

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3UPD

82.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family