Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05711 (show subtarget assignments)	1	soluble	No	BAS1732	49184745	-	oligopeptide ABC transporter, solute bin...	519	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	28.5%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05149 (show subtarget assignments)	1	purified	No	BA_0194	30253701		putative oligopeptide ABC transporter, o...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	30.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP01638 (show subtarget assignments)	1	soluble	No	CBU_0312	29540925	folD	folD bifunctional protein [Coxiella burn...	283	Conserved; Drug target functions	Phase 3: June 2008	1B0A	59.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90660 (show subtarget assignments)	8	cloned	No	Cj1476c	15792791		pyruvate ferredoxin/flavodoxin oxidoredu...	1186	Predicted Essential	Community Requests	1B0P	53.7%	Campylobacter jejuni

IDP00944 (show subtarget assignments)	1	crystallized	No	STM0891	16764252	artP	arginine transporter ATP-binding subunit...	242	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	43.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00529 (show subtarget assignments)	1	expressed	No	YPO2734	16122938	ccmA	putative heme exporter protein A	218	Virulence Associated Factor	Phase 2: March 2008	1B0U	27.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02457 (show subtarget assignments)	1	expressed	No	FTT1248	56708310		ABC transporter, ATP-binding protein [Fr...	253	Drug Target	Phase 3: June 2008	1B0U	31.1%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02803 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1960	16803999	fhuC	hypothetical protein lmo1960 [Listeria m...	274	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1B0U	28.5%	Listeria monocytogenes	Transport and binding proteins	Cations and iron carrying compounds

IDP01431 (show subtarget assignments)	1	purified	No	VC1864	15641866		amino acid ABC transporter, ATP-binding ...	256	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	62.9%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00737 (show subtarget assignments)	1	expressed	No	SACOL0993	57284367	oppD	oligopeptide ABC transporter, ATP-bindin...	360	Drug Target Function	Phase 2: March 2008	1B0U	25%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00143 (show subtarget assignments)	1	soluble	No	VC0779	15640798	viuC	vibriobactin and enterobactin ABC transp...	279	Virulence	Phase 1: October 2007	1B0U	29%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01758 (show subtarget assignments)	1	expressed	No	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02655 (show subtarget assignments)	1	cloned	No	GBAA3977	47529267	sipS-2	signal peptidase I S [Bacillus anthracis...	183	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	1B12	27.4%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02386 (show subtarget assignments)	1	selected	No	GBAA3086	47528378		Signal peptidase I [Bacillus anthracis s...	173	Drug target motif; Drug target functions	Phase 3: June 2008	1B12	10.4%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02758 (show subtarget assignments)	1	cloned	No	GBAA_pXO2_0073	47566739		signal peptidase i, (pxo2-59) [Bacillus ...	183	Drug target motif;	Phase 3: June 2008	1B12	8.7%	Bacillus anthracis	N/A	N/A

IDP01608 (show subtarget assignments)	1	cloned	No	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	Phase 3: June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01462 (show subtarget assignments)	1	soluble	No	VC2462	15642458		signal peptidase I	298	Drug Target Function	Phase 2: March 2008	1B12	46.6%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP02498 (show subtarget assignments)	1	cloned	No	FTT1556c	56708584	lepB	signal peptidase I [Francisella tularens...	287	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1B12	33.4%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP00515 (show subtarget assignments)	1	cloned	No	YPO3922	16124053		hemophore HasA	205	Virulence Associated Factor	Phase 2: March 2008	1B2V	29.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00312 (show subtarget assignments)	1	expressed	No	CBU_0497	29653839	fabF	3-oxoacyl-acyl carrier protein synthase ...	414	Drug Target Function	Phase 2: March 2008	1B3N	60.1%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00409 (show subtarget assignments)	1	purified	No	YPO1601	16121869	fabF	3-oxoacyl-(acyl carrier protein) synthas...	413	Conserved Gene / Pathway	Phase 2: March 2008	1B3N	89.1%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01439 (show subtarget assignments)	1	crystallized	No	VC2019	15642021		3-oxoacyl-(acyl carrier protein) synthas...	414	Drug Target Function	Phase 2: March 2008	1B3N	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01924 (show subtarget assignments)	1	purified	No	lmo0692	16802734	cheA	two-component sensor histidine kinase Ch...	618	Known virulence-Regulation; PMID:15155625	Phase 3: June 2008	1B3Q	26.5%	Listeria monocytogenes	Cellular processes	Chemotaxis and motility

IDP02422 (show subtarget assignments)	1	cloned	No	YPO1666	16121930	cheA	chemotaxis protein CheA [Yersinia pestis...	723	Conserved; CD; Drug target functions	Phase 3: June 2008	1B3Q	22.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP04244 (show subtarget assignments)	1	soluble	No	CPF_1171	110801284		sensor histidine kinase [Clostridium per...	410	conserved gene; putative drug target function;	Phase 4: April 2009	1B3Q	9.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP90713 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0995c	15792322	hemB	delta-aminolevulinic acid dehydratase [C...	327	Predicted Essential	Community Requests	1B4E	51.1%	Campylobacter jejuni

IDP00745 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1715	57284726	hemB	delta-aminolevulinic acid dehydratase	324	Drug Target Function	Phase 2: March 2008	1B4E	47.8%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90763 (show subtarget assignments)	8	in_crystallization_trials	No	VC0105	15640137		delta-aminolevulinic acid dehydratase [V...	347	Predicted Essential	Community Requests	1B4K	66.9%	Vibrio cholerae

IDP90791 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3771	16123907	hemB	delta-aminolevulinic acid dehydratase [Y...	340	Predicted Essential	Community Requests	1B4K	66.8%	Yersinia pestis

IDP91828 (show subtarget assignments)	8	soluble	No	b2925	1789293	fbaA	fructose-bisphosphate aldolase, class II...	359	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1B57	99.7%	Escherichia coli

IDP91391 (show subtarget assignments)	8	cloned	No	VV1_1292	27364692	mutL	DNA mismatch repair protein [Vibrio vuln...	664	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1B62	36.4%	Vibrio vulnificus

IDP92099 (show subtarget assignments)	8	selected	No	TGME49_105460	237842063		methionine aminopeptidase, type II, puta...	480	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1B6A	44.8%	Toxoplasma gondii

IDP04479 (show subtarget assignments)	1	purified	No	YPO3077	115348733	purK	phosphoribosylaminoimidazole carboxylase...	354	conserved gene; putative drug target function;	Phase 4: April 2009	1B6S	76.8%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00922 (show subtarget assignments)	1	soluble	No	STM0533	16763913	purK	phosphoribosylaminoimidazole carboxylase...	355	Conserved Gene / Pathway	Phase 2: March 2008	1B6S	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP91357 (show subtarget assignments)	8	soluble	No	VV1_2850	27366131		50S ribosomal protein L25 [Vibrio vulnif...	92	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1B75	56.5%	Vibrio vulnificus

IDP91960 (show subtarget assignments)	8	selected	No	SpneCM_010100008232	298255567		carbamate kinase [Streptococcus pneumoni...	423	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B7B	24.1%	Streptococcus pneumoniae

IDP05379 (show subtarget assignments)	1	soluble	No	BA_5417	30259888	cccB	cytochrome c-551 [Bacillus anthracis str...	107	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B7V	29.9%	Bacillus anthracis	Energy metabolism: Electron transport

IDP90595 (show subtarget assignments)	8	expressed	No	YPO2298	16122522	phoA	alkaline phosphatase [Yersinia pestis CO...	481	Predicted Essential	Community Requests	1B8J	70.7%	Yersinia pestis

IDP00934 (show subtarget assignments)	0	work_stopped	No	STM0779	16764143	modE	DNA-binding transcriptional dual regulat...	262	Conserved Gene / Pathway	Phase 2: March 2008	1B9M	89.3%	Salmonella enterica	Transport and binding proteins	Anions

IDP90685 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0401	15791768	lysS	lysyl-tRNA synthetase [Campylobacter jej...	501	Predicted Essential	Community Requests	1BBU	48.1%	Campylobacter jejuni

IDP90637 (show subtarget assignments)	8	soluble	No	YPO0888	16121193	lysS	lysyl-tRNA synthetase [Yersinia pestis C...	505	Predicted Essential	Community Requests	1BBU	85.7%	Yersinia pestis

IDP00052 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3500	30258038	bla2	beta-lactamase II	256	Virulence	Phase 1: October 2007	1BC2	81.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00754 (show subtarget assignments)	0	work_stopped	No	SACOL0095	57286644	spa	immunoglobulin G binding protein A precu...	508	Conserved Gene / Pathway	Phase 2: March 2008	1BDC	11.6%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP92070 (show subtarget assignments)	8	selected	No	TGME49_084010	237839683		DNA polymerase I, putative [Toxoplasma g...	461	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1BGX	16.9%	Toxoplasma gondii

IDP91813 (show subtarget assignments)	8	soluble	No	b0116	1786307	lpd	lipoamide dehydrogenase, E3 component is...	474	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1BHY	63.6%	Escherichia coli

IDP90933 (show subtarget assignments)	8	expressed	No	YPO3759	16123896	birA	biotin--protein ligase [Yersinia pestis ...	319	Predicted Essential	Community Requests	1BIA	75.2%	Yersinia pestis

IDP02794 (show subtarget assignments)	1	purified	No	FTT0477c	56707619	birA	transcription repressor BirA [Francisell...	260	Conserved; Drug target functions	Phase 3: June 2008	1BIA	25.8%	Francisella tularensis	Protein fate	Protein modification and repair

IDP90597 (show subtarget assignments)	8	soluble	No	VC0319	15640346		biotin--protein ligase [Vibrio cholerae ...	320	Predicted Essential	Community Requests	1BIA	54.7%	Vibrio cholerae

IDP02176 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1002	29541584	birA	birA bifunctional protein [Coxiella burn...	323	Conserved; Drug target functions	Phase 3: June 2008	1BIA	34.1%	Coxiella burnetii	Regulatory functions	DNA interactions

IDP04346 (show subtarget assignments)	1	expressed	No	VC1159	15641172		phosphoserine aminotransferase [Vibrio c...	379	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BJN	63.3%	Vibrio cholerae	Amino acid biosynthesis	Serine family

IDP90520 (show subtarget assignments)	8	purified	No	Q9KSU7	29611872		RecName: Full=Phosphoserine aminotransfe...	364	Predicted Essential	Community Requests	1BJN	65.9%	Vibrio cholerae

IDP02483 (show subtarget assignments)	1	cloned	No	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04127 (show subtarget assignments)	1	crystallized	No	YPO2889	115348559	pepB	peptidase B [Yersinia pestis CO92]	432	drug target; putative drug target function;	Phase 4: April 2009	1BLL	32.9%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91751 (show subtarget assignments)	8	selected	No	STRP_STREQ	0			440	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1BML	81.1%	Streptococcus dysgalactiae

IDP90725 (show subtarget assignments)	8	soluble	No	VC0295	15640323		acetyl-CoA carboxylase biotin carboxylas...	447	Predicted Essential	Community Requests	1BNC	85.5%	Vibrio cholerae

IDP01778 (show subtarget assignments)	1	cloned	No	YPO3689	16123828		putative ribonuclease [Yersinia pestis C...	152	Conserved; CD; Drug target functions	Phase 3: June 2008	1BNE	42.1%	Yersinia pestis	Transcription	Degradation of RNA

IDP04134 (show subtarget assignments)	1	expressed	No	FTT0666c	56707787		methylpurine-DNA glycosylase family prot...	193	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BNK	39.7%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02272 (show subtarget assignments)	1	cloned	No	GBAA2183	47527475		neutral metalloprotease, putative [Bacil...	503	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	1BQB	14.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02657 (show subtarget assignments)	1	cloned	No	lmo0203	16802249	mpl	Zinc metalloproteinase precursor [Lister...	510	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...	Phase 3: June 2008	1BQB	27.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90899 (show subtarget assignments)	8	soluble	No	YPO3949	16124077	asd	aspartate-semialdehyde dehydrogenase [Ye...	367	Predicted Essential	Community Requests	1BRM	83.4%	Yersinia pestis

IDP01495 (show subtarget assignments)	1	cloned	No	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02629 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01953 (show subtarget assignments)	1	soluble	No	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00937 (show subtarget assignments)	1	cloned	No	STM0795	16764158	bioF	8-amino-7-oxononanoate synthase	385	Conserved Gene / Pathway	Phase 2: March 2008	1BS0	80%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90894 (show subtarget assignments)	8	expressed	No	YPO2046	16122285	argS	arginyl-tRNA synthetase [Yersinia pestis...	576	Predicted Essential	Community Requests	1BS2	31.1%	Yersinia pestis

IDP05141 (show subtarget assignments)	1	cloned	No	BAS2021	49185032	argS	arginyl-tRNA synthetase [Bacillus anthra...	562	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1BS2	36.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP02149 (show subtarget assignments)	1	cloned	No	Cj1428c	15792746	fcl	putative fucose synthetase [Campylobacte...	346	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1BSV	38.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90512 (show subtarget assignments)	8	in_crystallization_trials	No	Q9KVL6	21362496		RecName: Full=Diaminopimelate epimerase;...	276	Predicted Essential	Community Requests	1BWZ	73.6%	Vibrio cholerae

IDP04043 (show subtarget assignments)	1	soluble	No	VCA0565	15601324		sensor histidine kinase [Vibrio cholerae...	499	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	6%	Vibrio cholerae	Regulatory functions	Other

IDP04544 (show subtarget assignments)	1	cloned	No	VC2713	9657310		osmolarity sensor protein EnvZ [Vibrio c...	438	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	16.7%	Vibrio cholerae	Regulatory functions	Other

IDP04339 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0115	49183149		50S ribosomal protein L22 [Bacillus anth...	113	Proposed to be essential proteins	Phase 4: April 2009	1BXE	59.3%	Bacillus anthracis

IDP90851 (show subtarget assignments)	8	purified	No	YPO3862	16123997	rffG	dTDP-D-glucose-4,6-dehydratase [Yersinia...	355	Predicted Essential	Community Requests	1BXK	82%	Yersinia pestis

IDP90859 (show subtarget assignments)	8	expressed	No	Cj1494c	15792809	carA	carbamoyl phosphate synthase small subun...	372	Predicted Essential	Community Requests	1BXR	40.3%	Campylobacter jejuni

IDP02722 (show subtarget assignments)	1	cloned	No	GBAA4026	47529319	carA	carbamoyl phosphate synthase small subun...	365	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1BXR	46.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00528 (show subtarget assignments)	1	expressed	No	YPO0481	16120811	carA	carbamoyl phosphate synthase small subun...	391	Drug Target Function	Phase 2: March 2008	1BXR	84.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02512 (show subtarget assignments)	1	soluble	No	FTT1663	56708674	carA	carbamoyl phosphate synthase small subun...	388	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1BXR	48.5%	Francisella tularensis	N/A	N/A

IDP90807 (show subtarget assignments)	8	cloned	No	Cj0279	15791649	carB	carbamoyl phosphate synthase large subun...	1089	Predicted Essential	Community Requests	1BXR	55.3%	Campylobacter jejuni

IDP90592 (show subtarget assignments)	8	in_crystallization_trials	No	VC2389	15642386	carB	carbamoyl phosphate synthase large subun...	1076	Predicted Essential	Community Requests	1BXR	85.6%	Vibrio cholerae

IDP00671 (show subtarget assignments)	1	purified	No	SACOL1215	57285958	carB	carbamoyl phosphate synthase large subun...	1057	Drug Target Function	Phase 2: March 2008	1BXR	49.6%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04425 (show subtarget assignments)	1	cloned	No	GBAA4025	47529318	carB	carbamoyl phosphate synthase large subun...	1072	conserved gene; putative drug target function;	Phase 4: April 2009	1BXR	49.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90345 (show subtarget assignments)	8	cloned	No	CT157	15604876		phospholipase D endonuclease superfamily...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1BYR	8.9%	Chlamydia trachomatis

IDP04057 (show subtarget assignments)	1	purified	No	BAS0125	49183159		50S ribosomal protein L6 [Bacillus anthr...	179	Proposed to be essential proteins	Phase 4: April 2009	1C04	74.9%	Bacillus anthracis

IDP04107 (show subtarget assignments)	1	purified	No	BAS0120	49183154		50S ribosomal protein L14 [Bacillus anth...	122	Proposed to be essential proteins	Phase 4: April 2009	1C04	86.9%	Bacillus anthracis

IDP05764 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2617	16804655	rplF	50S ribosomal protein L6 [Listeria monoc...	178	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1C04	73%	Listeria monocytogenes	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP90878 (show subtarget assignments)	8	in_crystallization_trials	No	VC1166	15641179	aspS	aspartyl-tRNA synthetase [Vibrio cholera...	591	Predicted Essential	Community Requests	1C0A	74.8%	Vibrio cholerae

IDP90630 (show subtarget assignments)	8	soluble	No	Cj0640c	15792000	aspS	aspartyl-tRNA synthetase [Campylobacter ...	583	Predicted Essential	Community Requests	1C0A	51.8%	Campylobacter jejuni

IDP05303 (show subtarget assignments)	1	cloned	No	SACOL1685	57650511	aspS	aspartyl-tRNA synthetase [Staphylococcus...	588	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1C0A	54.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP02686 (show subtarget assignments)	1	soluble	No	FTT0393	56707542	map	methionine aminopeptidase [Francisella t...	256	Conserved; Drug target functions; Drug target motif	Community Interest	1C21	59.4%	Francisella tularensis	N/A	N/A

IDP04144 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3337	218930358	map	methionine aminopeptidase [Yersinia pest...	261	drug target; virulence factor; putative drug target function;	Community Interest	1C21	55.2%	Yersinia pestis	Protein fate	Protein modification and repair

IDP90536 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0187c	15791574	purN	phosphoribosylglycinamide formyltransfer...	188	Predicted Essential	Community Requests	1C2T	38.6%	Campylobacter jejuni

IDP04644 (show subtarget assignments)	1	cloned	No	FTT0895	56707996	purN	phosphoribosylglycinamide formyltransfer...	191	conserved gene;	Phase 4: April 2009	1C2T	40.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00987 (show subtarget assignments)	1	soluble	No	STM2147	16765476	thiM	hydroxyethylthiazole kinase	265	Conserved Gene / Pathway	Phase 2: March 2008	1C3Q	36.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP04294 (show subtarget assignments)	1	cloned	No	YPO3477	115349102		putative lipid carrier protein [Yersinia...	173	conserved gene; putative drug target function;	Phase 4: April 2009	1C44	13.3%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02183 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0414	56707563	pgm	phosphoglucomutase [Francisella tularens...	544	Drug Target	Phase 3: June 2008	1C47	54.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02321 (show subtarget assignments)	1	cloned	No	FTT0077	56707256	sucB	dihydrolipoamide succinyltransferase com...	489	Conserved; Drug target functions	Phase 3: June 2008	1C4T	29.9%	Francisella tularensis	Energy metabolism	TCA cycle

IDP00493 (show subtarget assignments)	1	expressed	No	YPO1124	16121424	tolB	translocation protein TolB	430	Conserved Gene / Pathway	Phase 2: March 2008	1C5K	84.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP02122 (show subtarget assignments)	1	cloned	No	CBU_0090	29540712	tolB	tolB protein [Coxiella burnetii RSA 493]...	437	Conserved; Drug target functions	Phase 3: June 2008	1C5K	40.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP00764 (show subtarget assignments)	1	expressed	No	SACOL0447	57286820		phosphoglycerate mutase family protein	193	Drug Target Function	Phase 2: March 2008	1C7Z	31.1%	Staphylococcus aureus	Unknown function	General

IDP01140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4546	33301122		Germination protease precursor (Spore pr...	368	Drug Target Function	Phase 2: March 2008	1C8B	70.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05711
(show subtarget assignments)

1

soluble

No

BAS1732

49184745

-

oligopeptide ABC transporter, solute bin...

519

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

28.5%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05149
(show subtarget assignments)

1

purified

No

BA_0194

30253701

putative oligopeptide ABC transporter, o...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

30.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP01638
(show subtarget assignments)

1

soluble

No

CBU_0312

29540925

folD

folD bifunctional protein [Coxiella burn...

283

Conserved; Drug target functions

Phase 3: June 2008

1B0A

59.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90660
(show subtarget assignments)

8

cloned

No

Cj1476c

15792791

pyruvate ferredoxin/flavodoxin oxidoredu...

1186

Predicted Essential

Community Requests

1B0P

53.7%

Campylobacter jejuni

IDP00944
(show subtarget assignments)

1

crystallized

No

STM0891

16764252

artP

arginine transporter ATP-binding subunit...

242

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

43.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00529
(show subtarget assignments)

1

expressed

No

YPO2734

16122938

ccmA

putative heme exporter protein A

218

Virulence Associated Factor

Phase 2: March 2008

1B0U

27.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02457
(show subtarget assignments)

1

expressed

No

FTT1248

56708310

ABC transporter, ATP-binding protein [Fr...

253

Drug Target

Phase 3: June 2008

1B0U

31.1%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02803
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1960

16803999

fhuC

hypothetical protein lmo1960 [Listeria m...

274

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1B0U

28.5%

Listeria monocytogenes

Transport and binding proteins

Cations and iron carrying compounds

IDP01431
(show subtarget assignments)

1

purified

No

VC1864

15641866

amino acid ABC transporter, ATP-binding ...

256

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

62.9%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00737
(show subtarget assignments)

1

expressed

No

SACOL0993

57284367

oppD

oligopeptide ABC transporter, ATP-bindin...

360

Drug Target Function

Phase 2: March 2008

1B0U

25%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00143
(show subtarget assignments)

1

soluble

No

VC0779

15640798

viuC

vibriobactin and enterobactin ABC transp...

279

Virulence

Phase 1: October 2007

1B0U

29%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01758
(show subtarget assignments)

1

expressed

No

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02655
(show subtarget assignments)

1

cloned

No

GBAA3977

47529267

sipS-2

signal peptidase I S [Bacillus anthracis...

183

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

1B12

27.4%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02386
(show subtarget assignments)

1

selected

No

GBAA3086

47528378

Signal peptidase I [Bacillus anthracis s...

173

Drug target motif; Drug target functions

Phase 3: June 2008

1B12

10.4%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02758
(show subtarget assignments)

1

cloned

No

GBAA_pXO2_0073

47566739

signal peptidase i, (pxo2-59) [Bacillus ...

183

Drug target motif;

Phase 3: June 2008

1B12

8.7%

Bacillus anthracis

N/A

IDP01608
(show subtarget assignments)

1

cloned

No

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

Phase 3: June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01462
(show subtarget assignments)

1

soluble

No

VC2462

15642458

signal peptidase I

298

Drug Target Function

Phase 2: March 2008

1B12

46.6%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP02498
(show subtarget assignments)

1

cloned

No

FTT1556c

56708584

lepB

signal peptidase I [Francisella tularens...

287

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1B12

33.4%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP00515
(show subtarget assignments)

1

cloned

No

YPO3922

16124053

hemophore HasA

205

Virulence Associated Factor

Phase 2: March 2008

1B2V

29.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00312
(show subtarget assignments)

1

expressed

No

CBU_0497

29653839

fabF

3-oxoacyl-acyl carrier protein synthase ...

414

Drug Target Function

Phase 2: March 2008

1B3N

60.1%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00409
(show subtarget assignments)

1

purified

No

YPO1601

16121869

fabF

3-oxoacyl-(acyl carrier protein) synthas...

413

Conserved Gene / Pathway

Phase 2: March 2008

1B3N

89.1%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01439
(show subtarget assignments)

1

crystallized

No

VC2019

15642021

3-oxoacyl-(acyl carrier protein) synthas...

414

Drug Target Function

Phase 2: March 2008

1B3N

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01924
(show subtarget assignments)

1

purified

No

lmo0692

16802734

cheA

two-component sensor histidine kinase Ch...

618

Known virulence-Regulation; PMID:15155625

Phase 3: June 2008

1B3Q

26.5%

Listeria monocytogenes

Cellular processes

Chemotaxis and motility

IDP02422
(show subtarget assignments)

1

cloned

No

YPO1666

16121930

cheA

chemotaxis protein CheA [Yersinia pestis...

723

Conserved; CD; Drug target functions

Phase 3: June 2008

1B3Q

22.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP04244
(show subtarget assignments)

1

soluble

No

CPF_1171

110801284

sensor histidine kinase [Clostridium per...

410

conserved gene; putative drug target function;

Phase 4: April 2009

1B3Q

9.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP90713
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0995c

15792322

hemB

delta-aminolevulinic acid dehydratase [C...

327

Predicted Essential

Community Requests

1B4E

51.1%

Campylobacter jejuni

IDP00745
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1715

57284726

hemB

delta-aminolevulinic acid dehydratase

324

Drug Target Function

Phase 2: March 2008

1B4E

47.8%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90763
(show subtarget assignments)

8

in_crystallization_trials

No

VC0105

15640137

delta-aminolevulinic acid dehydratase [V...

347

Predicted Essential

Community Requests

1B4K

66.9%

Vibrio cholerae

IDP90791
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3771

16123907

hemB

delta-aminolevulinic acid dehydratase [Y...

340

Predicted Essential

Community Requests

1B4K

66.8%

Yersinia pestis

IDP91828
(show subtarget assignments)

8

soluble

No

b2925

1789293

fbaA

fructose-bisphosphate aldolase, class II...

359

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1B57

99.7%

Escherichia coli

IDP91391
(show subtarget assignments)

8

cloned

No

VV1_1292

27364692

mutL

DNA mismatch repair protein [Vibrio vuln...

664

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1B62

36.4%

Vibrio vulnificus

IDP92099
(show subtarget assignments)

8

selected

No

TGME49_105460

237842063

methionine aminopeptidase, type II, puta...

480

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1B6A

44.8%

Toxoplasma gondii

IDP04479
(show subtarget assignments)

1

purified

No

YPO3077

115348733

purK

phosphoribosylaminoimidazole carboxylase...

354

conserved gene; putative drug target function;

Phase 4: April 2009

1B6S

76.8%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00922
(show subtarget assignments)

1

soluble

No

STM0533

16763913

purK

phosphoribosylaminoimidazole carboxylase...

355

Conserved Gene / Pathway

Phase 2: March 2008

1B6S

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP91357
(show subtarget assignments)

8

soluble

No

VV1_2850

27366131

50S ribosomal protein L25 [Vibrio vulnif...

92

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1B75

56.5%

Vibrio vulnificus

IDP91960
(show subtarget assignments)

8

selected

No

SpneCM_010100008232

298255567

carbamate kinase [Streptococcus pneumoni...

423

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B7B

24.1%

Streptococcus pneumoniae

IDP05379
(show subtarget assignments)

1

soluble

No

BA_5417

30259888

cccB

cytochrome c-551 [Bacillus anthracis str...

107

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B7V

29.9%

Bacillus anthracis

Energy metabolism: Electron transport

IDP90595
(show subtarget assignments)

8

expressed

No

YPO2298

16122522

phoA

alkaline phosphatase [Yersinia pestis CO...

481

Predicted Essential

Community Requests

1B8J

70.7%

Yersinia pestis

IDP00934
(show subtarget assignments)

0

work_stopped

No

STM0779

16764143

modE

DNA-binding transcriptional dual regulat...

262

Conserved Gene / Pathway

Phase 2: March 2008

1B9M

89.3%

Salmonella enterica

Transport and binding proteins

Anions

IDP90685
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0401

15791768

lysS

lysyl-tRNA synthetase [Campylobacter jej...

501

Predicted Essential

Community Requests

1BBU

48.1%

Campylobacter jejuni

IDP90637
(show subtarget assignments)

8

soluble

No

YPO0888

16121193

lysS

lysyl-tRNA synthetase [Yersinia pestis C...

505

Predicted Essential

Community Requests

1BBU

85.7%

Yersinia pestis

IDP00052
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3500

30258038

bla2

beta-lactamase II

256

Virulence

Phase 1: October 2007

1BC2

81.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00754
(show subtarget assignments)

0

work_stopped

No

SACOL0095

57286644

spa

immunoglobulin G binding protein A precu...

508

Conserved Gene / Pathway

Phase 2: March 2008

1BDC

11.6%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP92070
(show subtarget assignments)

8

selected

No

TGME49_084010

237839683

DNA polymerase I, putative [Toxoplasma g...

461

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1BGX

16.9%

Toxoplasma gondii

IDP91813
(show subtarget assignments)

8

soluble

No

b0116

1786307

lpd

lipoamide dehydrogenase, E3 component is...

474

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1BHY

63.6%

Escherichia coli

IDP90933
(show subtarget assignments)

8

expressed

No

YPO3759

16123896

birA

biotin--protein ligase [Yersinia pestis ...

319

Predicted Essential

Community Requests

1BIA

75.2%

Yersinia pestis

IDP02794
(show subtarget assignments)

1

purified

No

FTT0477c

56707619

birA

transcription repressor BirA [Francisell...

260

Conserved; Drug target functions

Phase 3: June 2008

1BIA

25.8%

Francisella tularensis

Protein fate

Protein modification and repair

IDP90597
(show subtarget assignments)

8

soluble

No

VC0319

15640346

biotin--protein ligase [Vibrio cholerae ...

320

Predicted Essential

Community Requests

1BIA

54.7%

Vibrio cholerae

IDP02176
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1002

29541584

birA

birA bifunctional protein [Coxiella burn...

323

Conserved; Drug target functions

Phase 3: June 2008

1BIA

34.1%

Coxiella burnetii

Regulatory functions

DNA interactions

IDP04346
(show subtarget assignments)

1

expressed

No

VC1159

15641172

phosphoserine aminotransferase [Vibrio c...

379

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BJN

63.3%

Vibrio cholerae

Amino acid biosynthesis

Serine family

IDP90520
(show subtarget assignments)

8

purified

No

Q9KSU7

29611872

RecName: Full=Phosphoserine aminotransfe...

364

Predicted Essential

Community Requests

1BJN

65.9%

Vibrio cholerae

IDP02483
(show subtarget assignments)

1

cloned

No

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04127
(show subtarget assignments)

1

crystallized

No

YPO2889

115348559

pepB

peptidase B [Yersinia pestis CO92]

432

drug target; putative drug target function;

Phase 4: April 2009

1BLL

32.9%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91751
(show subtarget assignments)

8

selected

No

STRP_STREQ

0

440

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1BML

81.1%

Streptococcus dysgalactiae

IDP90725
(show subtarget assignments)

8

soluble

No

VC0295

15640323

acetyl-CoA carboxylase biotin carboxylas...

447

Predicted Essential

Community Requests

1BNC

85.5%

Vibrio cholerae

IDP01778
(show subtarget assignments)

1

cloned

No

YPO3689

16123828

putative ribonuclease [Yersinia pestis C...

152

Conserved; CD; Drug target functions

Phase 3: June 2008

1BNE

42.1%

Yersinia pestis

Transcription

Degradation of RNA

IDP04134
(show subtarget assignments)

1

expressed

No

FTT0666c

56707787

methylpurine-DNA glycosylase family prot...

193

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BNK

39.7%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02272
(show subtarget assignments)

1

cloned

No

GBAA2183

47527475

neutral metalloprotease, putative [Bacil...

503

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

1BQB

14.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02657
(show subtarget assignments)

1

cloned

No

lmo0203

16802249

mpl

Zinc metalloproteinase precursor [Lister...

510

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...

Phase 3: June 2008

1BQB

27.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90899
(show subtarget assignments)

8

soluble

No

YPO3949

16124077

asd

aspartate-semialdehyde dehydrogenase [Ye...

367

Predicted Essential

Community Requests

1BRM

83.4%

Yersinia pestis

IDP01495
(show subtarget assignments)

1

cloned

No

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02629
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01953
(show subtarget assignments)

1

soluble

No

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00937
(show subtarget assignments)

1

cloned

No

STM0795

16764158

bioF

8-amino-7-oxononanoate synthase

385

Conserved Gene / Pathway

Phase 2: March 2008

1BS0

80%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90894
(show subtarget assignments)

8

expressed

No

YPO2046

16122285

argS

arginyl-tRNA synthetase [Yersinia pestis...

576

Predicted Essential

Community Requests

1BS2

31.1%

Yersinia pestis

IDP05141
(show subtarget assignments)

1

cloned

No

BAS2021

49185032

argS

arginyl-tRNA synthetase [Bacillus anthra...

562

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1BS2

36.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP02149
(show subtarget assignments)

1

cloned

No

Cj1428c

15792746

fcl

putative fucose synthetase [Campylobacte...

346

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1BSV

38.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90512
(show subtarget assignments)

8

in_crystallization_trials

No

Q9KVL6

21362496

RecName: Full=Diaminopimelate epimerase;...

276

Predicted Essential

Community Requests

1BWZ

73.6%

Vibrio cholerae

IDP04043
(show subtarget assignments)

1

soluble

No

VCA0565

15601324

sensor histidine kinase [Vibrio cholerae...

499

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

6%

Vibrio cholerae

Regulatory functions

Other

IDP04544
(show subtarget assignments)

1

cloned

No

VC2713

9657310

osmolarity sensor protein EnvZ [Vibrio c...

438

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

16.7%

Vibrio cholerae

Regulatory functions

Other

IDP04339
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0115

49183149

50S ribosomal protein L22 [Bacillus anth...

113

Proposed to be essential proteins

Phase 4: April 2009

1BXE

59.3%

Bacillus anthracis

IDP90851
(show subtarget assignments)

8

purified

No

YPO3862

16123997

rffG

dTDP-D-glucose-4,6-dehydratase [Yersinia...

355

Predicted Essential

Community Requests

1BXK

82%

Yersinia pestis

IDP90859
(show subtarget assignments)

8

expressed

No

Cj1494c

15792809

carA

carbamoyl phosphate synthase small subun...

372

Predicted Essential

Community Requests

1BXR

40.3%

Campylobacter jejuni

IDP02722
(show subtarget assignments)

1

cloned

No

GBAA4026

47529319

carA

carbamoyl phosphate synthase small subun...

365

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1BXR

46.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00528
(show subtarget assignments)

1

expressed

No

YPO0481

16120811

carA

carbamoyl phosphate synthase small subun...

391

Drug Target Function

Phase 2: March 2008

1BXR

84.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02512
(show subtarget assignments)

1

soluble

No

FTT1663

56708674

carA

carbamoyl phosphate synthase small subun...

388

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1BXR

48.5%

Francisella tularensis

N/A

IDP90807
(show subtarget assignments)

8

cloned

No

Cj0279

15791649

carB

carbamoyl phosphate synthase large subun...

1089

Predicted Essential

Community Requests

1BXR

55.3%

Campylobacter jejuni

IDP90592
(show subtarget assignments)

8

in_crystallization_trials

No

VC2389

15642386

carB

carbamoyl phosphate synthase large subun...

1076

Predicted Essential

Community Requests

1BXR

85.6%

Vibrio cholerae

IDP00671
(show subtarget assignments)

1

purified

No

SACOL1215

57285958

carB

carbamoyl phosphate synthase large subun...

1057

Drug Target Function

Phase 2: March 2008

1BXR

49.6%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04425
(show subtarget assignments)

1

cloned

No

GBAA4025

47529318

carB

carbamoyl phosphate synthase large subun...

1072

conserved gene; putative drug target function;

Phase 4: April 2009

1BXR

49.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90345
(show subtarget assignments)

8

cloned

No

CT157

15604876

phospholipase D endonuclease superfamily...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1BYR

8.9%

Chlamydia trachomatis

IDP04057
(show subtarget assignments)

1

purified

No

BAS0125

49183159

50S ribosomal protein L6 [Bacillus anthr...

179

Proposed to be essential proteins

Phase 4: April 2009

1C04

74.9%

Bacillus anthracis

IDP04107
(show subtarget assignments)

1

purified

No

BAS0120

49183154

50S ribosomal protein L14 [Bacillus anth...

122

Proposed to be essential proteins

Phase 4: April 2009

1C04

86.9%

Bacillus anthracis

IDP05764
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2617

16804655

rplF

50S ribosomal protein L6 [Listeria monoc...

178

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1C04

73%

Listeria monocytogenes

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP90878
(show subtarget assignments)

8

in_crystallization_trials

No

VC1166

15641179

aspS

aspartyl-tRNA synthetase [Vibrio cholera...

591

Predicted Essential

Community Requests

1C0A

74.8%

Vibrio cholerae

IDP90630
(show subtarget assignments)

8

soluble

No

Cj0640c

15792000

aspS

aspartyl-tRNA synthetase [Campylobacter ...

583

Predicted Essential

Community Requests

1C0A

51.8%

Campylobacter jejuni

IDP05303
(show subtarget assignments)

1

cloned

No

SACOL1685

57650511

aspS

aspartyl-tRNA synthetase [Staphylococcus...

588

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1C0A

54.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP02686
(show subtarget assignments)

1

soluble

No

FTT0393

56707542

map

methionine aminopeptidase [Francisella t...

256

Conserved; Drug target functions; Drug target motif

Community Interest

1C21

59.4%

Francisella tularensis

N/A

IDP04144
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3337

218930358

map

methionine aminopeptidase [Yersinia pest...

261

drug target; virulence factor; putative drug target function;

Community Interest

1C21

55.2%

Yersinia pestis

Protein fate

Protein modification and repair

IDP90536
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0187c

15791574

purN

phosphoribosylglycinamide formyltransfer...

188

Predicted Essential

Community Requests

1C2T

38.6%

Campylobacter jejuni

IDP04644
(show subtarget assignments)

1

cloned

No

FTT0895

56707996

purN

phosphoribosylglycinamide formyltransfer...

191

conserved gene;

Phase 4: April 2009

1C2T

40.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00987
(show subtarget assignments)

1

soluble

No

STM2147

16765476

thiM

hydroxyethylthiazole kinase

265

Conserved Gene / Pathway

Phase 2: March 2008

1C3Q

36.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP04294
(show subtarget assignments)

1

cloned

No

YPO3477

115349102

putative lipid carrier protein [Yersinia...

173

conserved gene; putative drug target function;

Phase 4: April 2009

1C44

13.3%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02183
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0414

56707563

pgm

phosphoglucomutase [Francisella tularens...

544

Drug Target

Phase 3: June 2008

1C47

54.4%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02321
(show subtarget assignments)

1

cloned

No

FTT0077

56707256

sucB

dihydrolipoamide succinyltransferase com...

489

Conserved; Drug target functions

Phase 3: June 2008

1C4T

29.9%

Francisella tularensis

Energy metabolism

TCA cycle

IDP00493
(show subtarget assignments)

1

expressed

No

YPO1124

16121424

tolB

translocation protein TolB

430

Conserved Gene / Pathway

Phase 2: March 2008

1C5K

84.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP02122
(show subtarget assignments)

1

cloned

No

CBU_0090

29540712

tolB

tolB protein [Coxiella burnetii RSA 493]...

437

Conserved; Drug target functions

Phase 3: June 2008

1C5K

40.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP00764
(show subtarget assignments)

1

expressed

No

SACOL0447

57286820

phosphoglycerate mutase family protein

193

Drug Target Function

Phase 2: March 2008

1C7Z

31.1%

Staphylococcus aureus

Unknown function

General

IDP01140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4546

33301122

Germination protease precursor (Spore pr...

368

Drug Target Function

Phase 2: March 2008

1C8B

70.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides