Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00101 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF2638	30041803	mrp	putative ATPase	369	Essential	Phase 1: October 2007	2PH1	27.1%	Shigella flexneri	Unknown function	General

IDP00102 (show subtarget assignments)	1	crystallized	No	NT01SF2944	30042031	evgA	putative positive transcription regulato...	204	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3F6C	64.7%	Shigella flexneri	Cell envelope	Surface structures

IDP00103 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF3270	30042295	ygaC	hypothetical protein S2885	114	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2G7J	86.8%	Shigella flexneri	Cell envelope	Other

IDP00104 (show subtarget assignments)	1	purified	No	NT01SF3305	30042319	srlB	PTS system, glucitol/sorbitol-specific e...	123	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2F9H	25.2%	Shigella flexneri	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00105 (show subtarget assignments)	1	purified	No	NT01SF3662	30042589	S3225	putative class II aminotransferase	116	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2X8U	40.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00106 (show subtarget assignments)	0	work_stopped	No	NT01SF3707	30042635	mdaB	modulator of drug activity B	193	Virulence	Phase 1: October 2007	2AMJ	97.9%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00107 (show subtarget assignments)	1	in_pdb 3DR3	No	NT01SF4834	30043015	argC	N-acetyl-gamma-glutamylphosphate reducta...	334	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DR3	100%	Shigella flexneri	Amino acid biosynthesis	Glutamate family

IDP00108 (show subtarget assignments)	1	purified	No	NT01SF4751	30043076	fdhE	FdhE protein	309	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FIY	39.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00109 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF4517	30043269	recF	Rec protein	357	Essential	Phase 1: October 2007	2O5V	27.2%	Shigella flexneri	DNA metabolism	DNA replication, recombination, and repair

IDP00110 (show subtarget assignments)	1	purified	No	NT01SF4145	30043548	glgC	glucose-1-phosphate adenylyltransferase ...	431	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3BRK	55.2%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00111 (show subtarget assignments)	1	in_pdb 3TV9	No	NT02SF4808	30043741	pmbA	putative peptide maturation protein	450	Virulence	Phase 1: October 2007	3TV9	96.2%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00112 (show subtarget assignments)	1	soluble	No	NT01SF5194	30043810	hflK	protease specific for phage lambda cII r...	419	Essential	Phase 1: October 2007	3BK6	11%	Shigella flexneri	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00113 (show subtarget assignments)	0	work_stopped	No	NT01SAA0015	16119212	blaI	PENICILLINASE REPRESSOR	126	Virulence	Phase 1: October 2007	1SD4	100%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00114 (show subtarget assignments)	1	purified	No	GVCV52ORF0478	9654887		Vibrio cholerae O1 biovar eltor str. N16...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3JVU	65.8%	Vibrio cholerae	Cell envelope	Surface structures

IDP00115 (show subtarget assignments)	1	crystallized	No	NT01VPA0514	28900406	VPA0551	hypothetical protein VPA0551 (gi 2890040...	181	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2OT9	33.7%	Vibrio parahaemolyticus	Cellular processes	Toxin production and resistance

IDP00116 (show subtarget assignments)	0	work_stopped	No	NT01ST0285	16763622	accA	acetylCoA carboxylase, carboxytransferas...	319	Essential	Phase 1: October 2007	2F9Y	96.9%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00117 (show subtarget assignments)	1	purified	No	NT01ST0298	16763632	yaeB	putative regulatory protein	235	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1XQB	47.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00118 (show subtarget assignments)	1	in_pdb 3MGA	No	NT01ST0713	16763963	fes	enterobactin/ferric enterobactin esteras...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3MGA	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP00120 (show subtarget assignments)	1	expressed	No	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP00121 (show subtarget assignments)	1	in_pdb 3DQQ	No	NT01ST3629	16766223	ygbK	putative tRNA synthase	420	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DQQ	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00122 (show subtarget assignments)	1	in_pdb 3CWC	Yes	NT01ST3693	16766265	STM2959	putative glycerate kinase 2	380	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3CWC	100%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00124 (show subtarget assignments)	0	work_stopped	No	NT01ST0382	16763693	ghmA	phosphoheptose isomerase	192		Phase 1: October 2007	2I22	97.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00125 (show subtarget assignments)	0	work_stopped	No	NT01ST1183	16764320	lrp	leucine-responsive transcriptional regul...	164		Phase 1: October 2007	2GQQ	98.8%	Salmonella enterica	Central intermediary metabolism	Other

IDP00126 (show subtarget assignments)	1	soluble	No	NT01ST1449	16764525	mviM	putative virulence protein	307	Virulence	Phase 1: October 2007	1TLT	81.4%	Salmonella enterica	Cellular processes	Pathogenesis

IDP00127 (show subtarget assignments)	1	soluble	No	NT01ST1705	16764721	sufC	cysteine desulfurase ATPase component	248	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2D3W	92.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00128 (show subtarget assignments)	1	soluble	No	NT01ST3027	16765755	pdxK	mp65f07.r1 Soares_thymus_2NbMT Mus muscu...	288	Essential	Phase 1: October 2007	2DDM	65.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00129 (show subtarget assignments)	0	work_stopped	No	NT01ST3985	16766479	mdaB	NADPH-specific quinone oxidoreductase	193	Virulence	Phase 1: October 2007	2AMJ	91.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00130 (show subtarget assignments)	1	in_crystallization_trials	No	NT01ST5659	16767805	yjjV	putative deoxyribonuclease YjjV	257	Virulence	Phase 1: October 2007	1ZZM	76.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00131 (show subtarget assignments)	0	work_stopped	No	NT01ST2113	16765046	rnb	exoribonuclease II	644	Essential	Phase 1: October 2007	2ID0	90.7%	Salmonella enterica	Transcription	Degradation of RNA

IDP00132 (show subtarget assignments)	1	purified	No	VC_0288	9654699	VC0288	Vibrio cholerae O1 biovar eltor str. N16...	618	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GP4	53.9%	Vibrio cholerae	Energy metabolism	Entner-Doudoroff

IDP00133 (show subtarget assignments)	1	purified	No	VC_2095	9656644	VC2095	Vibrio cholerae O1 biovar eltor str. N16...	548	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FUV	70.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP00134 (show subtarget assignments)	1	purified	No	VC_2250	9656811	VC2250	Vibrio cholerae O1 biovar eltor str. N16...	351	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3EH0	63%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00137 (show subtarget assignments)	1	in_crystallization_trials	No	VC_0959	9655418	VC0959	Vibrio cholerae O1 biovar eltor str. N16...	291	Virulence	Phase 1: October 2007	3NQR	29.6%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00138 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4159	30258665		conserved hypothetical protein	95	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ODM	56.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00139 (show subtarget assignments)	1	crystallized	No	BA_4355	30258855	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1VKN	40.5%	Bacillus anthracis	Unknown function	General

IDP00140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0197	30253704		pyrroline-5-carboxylate reductase, putat...	245	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3TRI	33.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00141 (show subtarget assignments)	1	crystallized	No	VC0401	15640428	mshK	MSHA biogenesis protein MshK	105	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00142 (show subtarget assignments)	1	cloned	No	VC1456	15641467	ctxB	cholera enterotoxin, B subunit	124	Virulence	Phase 1: October 2007	1EEI	81.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00143 (show subtarget assignments)	1	soluble	No	VC0779	15640798	viuC	vibriobactin and enterobactin ABC transp...	279	Virulence	Phase 1: October 2007	1B0U	29%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00144 (show subtarget assignments)	1	soluble	No	VC0776	15640795	viuP	vibriobactin and enterobactin ABC transp...	325	Virulence	Phase 1: October 2007	3R5S	91.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00145 (show subtarget assignments)	1	expressed	No	VC0777	15640796	viuD	vibriobactin and enterobactin ABC transp...	350	Virulence	Phase 1: October 2007	2NQ2	30.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00146 (show subtarget assignments)	1	soluble	No	VC0778	15640797	viuG	vibriobactin and enterobactin ABC transp...	358	Virulence	Phase 1: October 2007	2QI9	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00147 (show subtarget assignments)	1	expressed	No	VC0780	15640799	vibD	vibriobactin synthase component D	261	Virulence	Phase 1: October 2007			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00148 (show subtarget assignments)	1	soluble	No	VCA0227	15600996	vctP	vibriobactin and enterobactin ABC transp...	333	Virulence	Phase 1: October 2007	3GFV	30.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00149 (show subtarget assignments)	1	expressed	No	VCA0230	15600999	vctC	vibriobactin and enterobactin ABC transp...	254	Virulence	Phase 1: October 2007	2D62	28%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00150 (show subtarget assignments)	1	purified	No	VC0402	15640429	mshL	MSHA biogenesis protein MshL	559	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00151 (show subtarget assignments)	1	purified	No	VC0403	15640430	mshM	MSHA biogenesis protein MshM	281	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00152 (show subtarget assignments)	1	in_pdb 3DZC	Yes	VC0917	15640933	wecB	UDP-N-acetylglucosamine 2-epimerase	372	Virulence	Phase 1: October 2007	3DZC	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00153 (show subtarget assignments)	1	expressed	No	VC0475	15640502	irgA	enterobactin receptor	652	Virulence	Phase 1: October 2007	2HDF	37.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00154 (show subtarget assignments)	1	crystallized	No	VC2448	15642444	pyrG	CTP synthase	545	Essential	Phase 1: October 2007	1S1M	79.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00155 (show subtarget assignments)	1	in_crystallization_trials	No	VC0405	15640432	mshE	MSHA biogenesis protein MshE	575	Virulence	Phase 1: October 2007	1P9R	31.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00156 (show subtarget assignments)	1	purified	No	VC0407	15640434	mshF	MSHA biogenesis protein MshF	150	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00157 (show subtarget assignments)	1	soluble	No	VC0829	15640846	tcpB	toxin co-regulated pilus biosynthesis pr...	430	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00158 (show subtarget assignments)	1	soluble	No	VC0830	15640847	tcpQ	toxin co-regulated pilus biosynthesis pr...	150	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00159 (show subtarget assignments)	1	purified	No	VC0831	15640848	tcpC	toxin co-regulated pilus biosynthesis ou...	489	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00160 (show subtarget assignments)	1	soluble	No	VC0834	15640851	tcpS	toxin co-regulated pilus biosynthesis pr...	152	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00161 (show subtarget assignments)	1	soluble	No	VC0835	15640852	tcpT	toxin co-regulated pilus biosynthesis pr...	503	Virulence	Phase 1: October 2007	1P9R	23.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00162 (show subtarget assignments)	1	soluble	No	VC0837	15640854	tcpF	toxin co-regulated pilus biosynthesis pr...	338	Virulence	Phase 1: October 2007	3OC5	93.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00163 (show subtarget assignments)	0	work_stopped	No	VC0838	15640855	tcpN/toxT	TCP pilus virulence regulatory protein	276	Virulence	Phase 1: October 2007	3GBG	100%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00164 (show subtarget assignments)	1	soluble	No	VC0841	15640858	acfC	accessory colonization factor AcfC	256	Virulence	Phase 1: October 2007	3FIR	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00165 (show subtarget assignments)	1	cloned	No	VC0844	15640861	acfA	accessory colonization factor AcfA	215	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00166 (show subtarget assignments)	1	expressed	No	VC1450	15641461	rtxC	RTX toxin activating protein	153	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00167 (show subtarget assignments)	8	in_pdb 3FZY	Yes	VC1451	4455065	rtxA	RTX toxin RtxA	4545	Virulence	Community Requests	3EEB	4.6%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00168 (show subtarget assignments)	1	cloned	No	VC2209	15642774	vibF	nonribosomal peptide synthetase VibF, au...	2413	Virulence	Phase 1: October 2007	2VSQ	10.2%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP00169 (show subtarget assignments)	1	expressed	No	VCA0218	15600987	No Data	thermolabile hemolysin	418	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00170 (show subtarget assignments)	1	soluble	No	VCA0865	15601620	hap	hemagglutinin/protease	609	Virulence	Phase 1: October 2007	1EZM	31.4%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00171 (show subtarget assignments)	1	cloned	No	YPO0452	16120781	-	putative soluble lytic murein transglyco...	639	Similar to Essential SALTY	Phase 1: October 2007	1QSA	61.8%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00172 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2438	16122659	-	putative membrane-bound lytic murein tra...	220	Virulence	Phase 1: October 2007	2Y8P	42.7%	Yersinia pestis	Mobile and extrachromosomal element functions	Prophage functions

IDP00173 (show subtarget assignments)	1	cloned	No	YPO2922	16123109	-	putative membrane protein	486	Virulence	Phase 1: October 2007	3K4U	14.4%	Yersinia pestis	Unknown function	General

IDP00174 (show subtarget assignments)	1	cloned	No	YPO1140	16121437	-	putative membrane protein	272	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00175 (show subtarget assignments)	1	soluble	No	YPO1471	16121746	-	putative ATPase subunit of ATP-dependent...	880	Virulence	Phase 1: October 2007	1QVR	36.9%	Yersinia pestis

IDP00176 (show subtarget assignments)	1	cloned	No	YPO4024	16124147	-	putative iron transport permease	335	Virulence	Phase 1: October 2007	2QI9	23.9%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00177 (show subtarget assignments)	1	purified	No	YPO3007	16123186	-	putative membrane protein	509	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00178 (show subtarget assignments)	1	soluble	No	YPO3405	16123554	-	putative ABC transporter, integral membr...	256	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00179 (show subtarget assignments)	1	cloned	No	YPO0277	16120616	-	putative transmembrane transport protein...	428	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00180 (show subtarget assignments)	1	expressed	No	YPO0339	16120675	-	enhancing factor (viral)	856	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00181 (show subtarget assignments)	1	soluble	No	YPO0363	16120698	-	putative membrane transport protein	1119	Similar to Essential SALTY	Phase 1: October 2007	2OAU	5%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP00182 (show subtarget assignments)	1	soluble	No	YPO0398	16120732	-	M48 peptidase family protein	348	Similar to Essential SALTY	Phase 1: October 2007	3C37	10.1%	Yersinia pestis	Protein synthesis	Translation factors

IDP00183 (show subtarget assignments)	1	cloned	No	YPO0613	16120939	-	putative permease protein	293	Virulence	Phase 1: October 2007	2R6G	22.5%	Yersinia pestis

IDP00184 (show subtarget assignments)	1	cloned	No	YPO0624	16120950	-	putative membrane protein	483	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00185 (show subtarget assignments)	1	cloned	No	YPO0639	16120963	-	hypothetical protein	460	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00186 (show subtarget assignments)	1	soluble	No	YPO0695	16121016	-	putative membrane protein	140	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00187 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0773	16121086	-	putative thioesterase	254	Virulence	Phase 1: October 2007	3FLA	30.3%	Yersinia pestis	Regulatory functions	Other

IDP00188 (show subtarget assignments)	1	purified	No	YPO0806	16121118	-	prepilin peptidase	280	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00189 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0845	16121153	-	ThiJ/PfpI-family thiamine biogenesis pro...	192	Virulence	Phase 1: October 2007	1J42	29.2%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00190 (show subtarget assignments)	1	soluble	No	YPO0927	16121232	-	putative lipoprotein	250	Similar to Essential SALTY	Phase 1: October 2007	3C37	23.6%	Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00191 (show subtarget assignments)	1	cloned	No	YPO0932	16121236	-	conserved hypothetical protein	170	Virulence	Phase 1: October 2007			Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP00192 (show subtarget assignments)	1	cloned	No	YPO0947	16121251	-	putative virulence determinant	3110	Virulence	Phase 1: October 2007	1AF0	2.9%	Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP00193 (show subtarget assignments)	1	expressed	No	YPO0966	16121269	-	putative kinase	765	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00194 (show subtarget assignments)	1	cloned	No	YPO0983	16121287	-	putative membrane protein	216	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00195 (show subtarget assignments)	1	cloned	No	YPO1009	16121311	-	probable peptidase	410	Similar to Essential SALTY	Phase 1: October 2007	1VIX	38%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00196 (show subtarget assignments)	1	cloned	No	YPO1051	16121351	-	putative membrane protein	451	Virulence	Phase 1: October 2007	2ZPL	13.5%	Yersinia pestis

IDP00197 (show subtarget assignments)	1	purified	No	YPO1233	16121519	-	putative prophage repressor protein	240	Similar to Essential SALTY	Phase 1: October 2007	3BDN	46.2%	Yersinia pestis

IDP00198 (show subtarget assignments)	1	cloned	No	YPO1367	16121647	-	conserved hypothetical protein	106	Similar to Essential SALTY	Phase 1: October 2007	1MBU	84.9%	Yersinia pestis

IDP00199 (show subtarget assignments)	1	purified	No	YPO1431	16121710	-	putative Lon protease	590	Virulence	Phase 1: October 2007	3K1J	17.6%	Yersinia pestis	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP00200 (show subtarget assignments)	1	expressed	No	YPO1473	16121748	-	hypothetical protein	766	Virulence	Phase 1: October 2007			Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00201 (show subtarget assignments)	1	expressed	No	YPO1476	16121751	-	hypothetical protein	727	Virulence	Phase 1: October 2007			Yersinia pestis	Energy metabolism	Photosynthesis

IDP00202 (show subtarget assignments)	1	soluble	No	YPO2731	16122935	-	putative membrane protein	679	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00101
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF2638

30041803

mrp

putative ATPase

369

Essential

Phase 1: October 2007

2PH1

27.1%

Shigella flexneri

Unknown function

General

IDP00102
(show subtarget assignments)

1

crystallized

No

NT01SF2944

30042031

evgA

putative positive transcription regulato...

204

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3F6C

64.7%

Shigella flexneri

Cell envelope

Surface structures

IDP00103
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF3270

30042295

ygaC

hypothetical protein S2885

114

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2G7J

86.8%

Shigella flexneri

Cell envelope

Other

IDP00104
(show subtarget assignments)

1

purified

No

NT01SF3305

30042319

srlB

PTS system, glucitol/sorbitol-specific e...

123

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2F9H

25.2%

Shigella flexneri

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00105
(show subtarget assignments)

1

purified

No

NT01SF3662

30042589

S3225

putative class II aminotransferase

116

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2X8U

40.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00106
(show subtarget assignments)

0

work_stopped

No

NT01SF3707

30042635

mdaB

modulator of drug activity B

193

Virulence

Phase 1: October 2007

2AMJ

97.9%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00107
(show subtarget assignments)

1

in_pdb
3DR3

No

NT01SF4834

30043015

argC

N-acetyl-gamma-glutamylphosphate reducta...

334

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DR3

100%

Shigella flexneri

Amino acid biosynthesis

Glutamate family

IDP00108
(show subtarget assignments)

1

purified

No

NT01SF4751

30043076

fdhE

FdhE protein

309

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FIY

39.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00109
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF4517

30043269

recF

Rec protein

357

Essential

Phase 1: October 2007

2O5V

27.2%

Shigella flexneri

DNA metabolism

DNA replication, recombination, and repair

IDP00110
(show subtarget assignments)

1

purified

No

NT01SF4145

30043548

glgC

glucose-1-phosphate adenylyltransferase ...

431

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3BRK

55.2%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00111
(show subtarget assignments)

1

in_pdb
3TV9

No

NT02SF4808

30043741

pmbA

putative peptide maturation protein

450

Virulence

Phase 1: October 2007

3TV9

96.2%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00112
(show subtarget assignments)

1

soluble

No

NT01SF5194

30043810

hflK

protease specific for phage lambda cII r...

419

Essential

Phase 1: October 2007

3BK6

11%

Shigella flexneri

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00113
(show subtarget assignments)

0

work_stopped

No

NT01SAA0015

16119212

blaI

PENICILLINASE REPRESSOR

126

Virulence

Phase 1: October 2007

1SD4

100%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00114
(show subtarget assignments)

1

purified

No

GVCV52ORF0478

9654887

Vibrio cholerae O1 biovar eltor str. N16...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3JVU

65.8%

Vibrio cholerae

Cell envelope

Surface structures

IDP00115
(show subtarget assignments)

1

crystallized

No

NT01VPA0514

28900406

VPA0551

hypothetical protein VPA0551 (gi 2890040...

181

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2OT9

33.7%

Vibrio parahaemolyticus

Cellular processes

Toxin production and resistance

IDP00116
(show subtarget assignments)

0

work_stopped

No

NT01ST0285

16763622

accA

acetylCoA carboxylase, carboxytransferas...

319

Essential

Phase 1: October 2007

2F9Y

96.9%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00117
(show subtarget assignments)

1

purified

No

NT01ST0298

16763632

yaeB

putative regulatory protein

235

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1XQB

47.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00118
(show subtarget assignments)

1

in_pdb
3MGA

No

NT01ST0713

16763963

fes

enterobactin/ferric enterobactin esteras...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3MGA

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP00120
(show subtarget assignments)

1

expressed

No

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP00121
(show subtarget assignments)

1

in_pdb
3DQQ

No

NT01ST3629

16766223

ygbK

putative tRNA synthase

420

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DQQ

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00122
(show subtarget assignments)

1

in_pdb
3CWC

Yes

NT01ST3693

16766265

STM2959

putative glycerate kinase 2

380

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3CWC

100%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00124
(show subtarget assignments)

0

work_stopped

No

NT01ST0382

16763693

ghmA

phosphoheptose isomerase

192

Phase 1: October 2007

2I22

97.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00125
(show subtarget assignments)

0

work_stopped

No

NT01ST1183

16764320

lrp

leucine-responsive transcriptional regul...

164

Phase 1: October 2007

2GQQ

98.8%

Salmonella enterica

Central intermediary metabolism

Other

IDP00126
(show subtarget assignments)

1

soluble

No

NT01ST1449

16764525

mviM

putative virulence protein

307

Virulence

Phase 1: October 2007

1TLT

81.4%

Salmonella enterica

Cellular processes

Pathogenesis

IDP00127
(show subtarget assignments)

1

soluble

No

NT01ST1705

16764721

sufC

cysteine desulfurase ATPase component

248

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2D3W

92.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00128
(show subtarget assignments)

1

soluble

No

NT01ST3027

16765755

pdxK

mp65f07.r1 Soares_thymus_2NbMT Mus muscu...

288

Essential

Phase 1: October 2007

2DDM

65.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00129
(show subtarget assignments)

0

work_stopped

No

NT01ST3985

16766479

mdaB

NADPH-specific quinone oxidoreductase

193

Virulence

Phase 1: October 2007

2AMJ

91.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00130
(show subtarget assignments)

1

in_crystallization_trials

No

NT01ST5659

16767805

yjjV

putative deoxyribonuclease YjjV

257

Virulence

Phase 1: October 2007

1ZZM

76.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00131
(show subtarget assignments)

0

work_stopped

No

NT01ST2113

16765046

rnb

exoribonuclease II

644

Essential

Phase 1: October 2007

2ID0

90.7%

Salmonella enterica

Transcription

Degradation of RNA

IDP00132
(show subtarget assignments)

1

purified

No

VC_0288

9654699

VC0288

Vibrio cholerae O1 biovar eltor str. N16...

618

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GP4

53.9%

Vibrio cholerae

Energy metabolism

Entner-Doudoroff

IDP00133
(show subtarget assignments)

1

purified

No

VC_2095

9656644

VC2095

Vibrio cholerae O1 biovar eltor str. N16...

548

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FUV

70.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP00134
(show subtarget assignments)

1

purified

No

VC_2250

9656811

VC2250

Vibrio cholerae O1 biovar eltor str. N16...

351

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3EH0

63%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00137
(show subtarget assignments)

1

in_crystallization_trials

No

VC_0959

9655418

VC0959

Vibrio cholerae O1 biovar eltor str. N16...

291

Virulence

Phase 1: October 2007

3NQR

29.6%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00138
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4159

30258665

conserved hypothetical protein

95

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ODM

56.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00139
(show subtarget assignments)

1

crystallized

No

BA_4355

30258855

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1VKN

40.5%

Bacillus anthracis

Unknown function

General

IDP00140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0197

30253704

pyrroline-5-carboxylate reductase, putat...

245

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3TRI

33.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00141
(show subtarget assignments)

1

crystallized

No

VC0401

15640428

mshK

MSHA biogenesis protein MshK

105

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00142
(show subtarget assignments)

1

cloned

No

VC1456

15641467

ctxB

cholera enterotoxin, B subunit

124

Virulence

Phase 1: October 2007

1EEI

81.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00143
(show subtarget assignments)

1

soluble

No

VC0779

15640798

viuC

vibriobactin and enterobactin ABC transp...

279

Virulence

Phase 1: October 2007

1B0U

29%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00144
(show subtarget assignments)

1

soluble

No

VC0776

15640795

viuP

vibriobactin and enterobactin ABC transp...

325

Virulence

Phase 1: October 2007

3R5S

91.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00145
(show subtarget assignments)

1

expressed

No

VC0777

15640796

viuD

vibriobactin and enterobactin ABC transp...

350

Virulence

Phase 1: October 2007

2NQ2

30.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00146
(show subtarget assignments)

1

soluble

No

VC0778

15640797

viuG

vibriobactin and enterobactin ABC transp...

358

Virulence

Phase 1: October 2007

2QI9

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00147
(show subtarget assignments)

1

expressed

No

VC0780

15640799

vibD

vibriobactin synthase component D

261

Virulence

Phase 1: October 2007

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00148
(show subtarget assignments)

1

soluble

No

VCA0227

15600996

vctP

vibriobactin and enterobactin ABC transp...

333

Virulence

Phase 1: October 2007

3GFV

30.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00149
(show subtarget assignments)

1

expressed

No

VCA0230

15600999

vctC

vibriobactin and enterobactin ABC transp...

254

Virulence

Phase 1: October 2007

2D62

28%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00150
(show subtarget assignments)

1

purified

No

VC0402

15640429

mshL

MSHA biogenesis protein MshL

559

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00151
(show subtarget assignments)

1

purified

No

VC0403

15640430

mshM

MSHA biogenesis protein MshM

281

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00152
(show subtarget assignments)

1

in_pdb
3DZC

Yes

VC0917

15640933

wecB

UDP-N-acetylglucosamine 2-epimerase

372

Virulence

Phase 1: October 2007

3DZC

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00153
(show subtarget assignments)

1

expressed

No

VC0475

15640502

irgA

enterobactin receptor

652

Virulence

Phase 1: October 2007

2HDF

37.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00154
(show subtarget assignments)

1

crystallized

No

VC2448

15642444

pyrG

CTP synthase

545

Essential

Phase 1: October 2007

1S1M

79.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00155
(show subtarget assignments)

1

in_crystallization_trials

No

VC0405

15640432

mshE

MSHA biogenesis protein MshE

575

Virulence

Phase 1: October 2007

1P9R

31.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00156
(show subtarget assignments)

1

purified

No

VC0407

15640434

mshF

MSHA biogenesis protein MshF

150

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00157
(show subtarget assignments)

1

soluble

No

VC0829

15640846

tcpB

toxin co-regulated pilus biosynthesis pr...

430

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00158
(show subtarget assignments)

1

soluble

No

VC0830

15640847

tcpQ

toxin co-regulated pilus biosynthesis pr...

150

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00159
(show subtarget assignments)

1

purified

No

VC0831

15640848

tcpC

toxin co-regulated pilus biosynthesis ou...

489

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00160
(show subtarget assignments)

1

soluble

No

VC0834

15640851

tcpS

toxin co-regulated pilus biosynthesis pr...

152

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00161
(show subtarget assignments)

1

soluble

No

VC0835

15640852

tcpT

toxin co-regulated pilus biosynthesis pr...

503

Virulence

Phase 1: October 2007

1P9R

23.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00162
(show subtarget assignments)

1

soluble

No

VC0837

15640854

tcpF

toxin co-regulated pilus biosynthesis pr...

338

Virulence

Phase 1: October 2007

3OC5

93.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00163
(show subtarget assignments)

0

work_stopped

No

VC0838

15640855

tcpN/toxT

TCP pilus virulence regulatory protein

276

Virulence

Phase 1: October 2007

3GBG

100%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00164
(show subtarget assignments)

1

soluble

No

VC0841

15640858

acfC

accessory colonization factor AcfC

256

Virulence

Phase 1: October 2007

3FIR

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00165
(show subtarget assignments)

1

cloned

No

VC0844

15640861

acfA

accessory colonization factor AcfA

215

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00166
(show subtarget assignments)

1

expressed

No

VC1450

15641461

rtxC

RTX toxin activating protein

153

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00167
(show subtarget assignments)

8

in_pdb
3FZY

Yes

VC1451

4455065

rtxA

RTX toxin RtxA

4545

Virulence

Community Requests

3EEB

4.6%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00168
(show subtarget assignments)

1

cloned

No

VC2209

15642774

vibF

nonribosomal peptide synthetase VibF, au...

2413

Virulence

Phase 1: October 2007

2VSQ

10.2%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP00169
(show subtarget assignments)

1

expressed

No

VCA0218

15600987

No Data

thermolabile hemolysin

418

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00170
(show subtarget assignments)

1

soluble

No

VCA0865

15601620

hap

hemagglutinin/protease

609

Virulence

Phase 1: October 2007

1EZM

31.4%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00171
(show subtarget assignments)

1

cloned

No

YPO0452

16120781

-

putative soluble lytic murein transglyco...

639

Similar to Essential SALTY

Phase 1: October 2007

1QSA

61.8%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00172
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2438

16122659

-

putative membrane-bound lytic murein tra...

220

Virulence

Phase 1: October 2007

2Y8P

42.7%

Yersinia pestis

Mobile and extrachromosomal element functions

Prophage functions

IDP00173
(show subtarget assignments)

1

cloned

No

YPO2922

16123109

-

putative membrane protein

486

Virulence

Phase 1: October 2007

3K4U

14.4%

Yersinia pestis

Unknown function

General

IDP00174
(show subtarget assignments)

1

cloned

No

YPO1140

16121437

-

putative membrane protein

272

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00175
(show subtarget assignments)

1

soluble

No

YPO1471

16121746

-

putative ATPase subunit of ATP-dependent...

880

Virulence

Phase 1: October 2007

1QVR

36.9%

Yersinia pestis

IDP00176
(show subtarget assignments)

1

cloned

No

YPO4024

16124147

-

putative iron transport permease

335

Virulence

Phase 1: October 2007

2QI9

23.9%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00177
(show subtarget assignments)

1

purified

No

YPO3007

16123186

-

putative membrane protein

509

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00178
(show subtarget assignments)

1

soluble

No

YPO3405

16123554

-

putative ABC transporter, integral membr...

256

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00179
(show subtarget assignments)

1

cloned

No

YPO0277

16120616

-

putative transmembrane transport protein...

428

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00180
(show subtarget assignments)

1

expressed

No

YPO0339

16120675

-

enhancing factor (viral)

856

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00181
(show subtarget assignments)

1

soluble

No

YPO0363

16120698

-

putative membrane transport protein

1119

Similar to Essential SALTY

Phase 1: October 2007

2OAU

5%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP00182
(show subtarget assignments)

1

soluble

No

YPO0398

16120732

-

M48 peptidase family protein

348

Similar to Essential SALTY

Phase 1: October 2007

3C37

10.1%

Yersinia pestis

Protein synthesis

Translation factors

IDP00183
(show subtarget assignments)

1

cloned

No

YPO0613

16120939

-

putative permease protein

293

Virulence

Phase 1: October 2007

2R6G

22.5%

Yersinia pestis

IDP00184
(show subtarget assignments)

1

cloned

No

YPO0624

16120950

-

putative membrane protein

483

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00185
(show subtarget assignments)

1

cloned

No

YPO0639

16120963

-

hypothetical protein

460

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00186
(show subtarget assignments)

1

soluble

No

YPO0695

16121016

-

putative membrane protein

140

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00187
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0773

16121086

-

putative thioesterase

254

Virulence

Phase 1: October 2007

3FLA

30.3%

Yersinia pestis

Regulatory functions

Other

IDP00188
(show subtarget assignments)

1

purified

No

YPO0806

16121118

-

prepilin peptidase

280

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00189
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0845

16121153

-

ThiJ/PfpI-family thiamine biogenesis pro...

192

Virulence

Phase 1: October 2007

1J42

29.2%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00190
(show subtarget assignments)

1

soluble

No

YPO0927

16121232

-

putative lipoprotein

250

Similar to Essential SALTY

Phase 1: October 2007

3C37

23.6%

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00191
(show subtarget assignments)

1

cloned

No

YPO0932

16121236

-

conserved hypothetical protein

170

Virulence

Phase 1: October 2007

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP00192
(show subtarget assignments)

1

cloned

No

YPO0947

16121251

-

putative virulence determinant

3110

Virulence

Phase 1: October 2007

1AF0

2.9%

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP00193
(show subtarget assignments)

1

expressed

No

YPO0966

16121269

-

putative kinase

765

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00194
(show subtarget assignments)

1

cloned

No

YPO0983

16121287

-

putative membrane protein

216

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00195
(show subtarget assignments)

1

cloned

No

YPO1009

16121311

-

probable peptidase

410

Similar to Essential SALTY

Phase 1: October 2007

1VIX

38%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00196
(show subtarget assignments)

1

cloned

No

YPO1051

16121351

-

putative membrane protein

451

Virulence

Phase 1: October 2007

2ZPL

13.5%

Yersinia pestis

IDP00197
(show subtarget assignments)

1

purified

No

YPO1233

16121519

-

putative prophage repressor protein

240

Similar to Essential SALTY

Phase 1: October 2007

3BDN

46.2%

Yersinia pestis

IDP00198
(show subtarget assignments)

1

cloned

No

YPO1367

16121647

-

conserved hypothetical protein

106

Similar to Essential SALTY

Phase 1: October 2007

1MBU

84.9%

Yersinia pestis

IDP00199
(show subtarget assignments)

1

purified

No

YPO1431

16121710

-

putative Lon protease

590

Virulence

Phase 1: October 2007

3K1J

17.6%

Yersinia pestis

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP00200
(show subtarget assignments)

1

expressed

No

YPO1473

16121748

-

hypothetical protein

766

Virulence

Phase 1: October 2007

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00201
(show subtarget assignments)

1

expressed

No

YPO1476

16121751

-

hypothetical protein

727

Virulence

Phase 1: October 2007

Yersinia pestis

Energy metabolism

Photosynthesis

IDP00202
(show subtarget assignments)

1

soluble

No

YPO2731

16122935

-

putative membrane protein

679

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

Targets