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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 2 of 60, showing 100 records out of 5973 total, starting on record 101
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00630
(
show subtarget assignments
)
1
cloned
No
SACOL0861
57284322
cold shock protein, CSD family
66
Conserved Gene / Pathway
Phase 2: March 2008
2I5M
71.2%
Staphylococcus aureus
Cellular processes
Adaptations to atypical conditions
IDP02267
(
show subtarget assignments
)
1
soluble
No
GBAA0987
47526266
hypothetical protein GBAA0987 [Bacillus ...
66
Conserved;
Phase 3: June 2008
Bacillus anthracis
Hypothetical proteins
Conserved
IDP00610
(
show subtarget assignments
)
1
cloned
No
SACOL1437
57286088
cold shock protein, CSD family
66
Conserved Gene / Pathway
Phase 2: March 2008
1CSP
75.8%
Staphylococcus aureus
Cellular processes
Adaptations to atypical conditions
IDP02757
(
show subtarget assignments
)
1
cloned
No
STM2484
16765804
hypothetical protein STM2484 [Salmonella...
66
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP02334
(
show subtarget assignments
)
1
soluble
No
FTT0391c
56707540
cspC
cold shock protein [Francisella tularens...
67
Drug Target
Phase 3: June 2008
3I2Z
61.8%
Francisella tularensis
Cellular processes
Adaptations to atypical conditions
IDP01742
(
show subtarget assignments
)
1
cloned
No
STM3621
16766907
yhjR
putative cytoplasmic protein [Salmonella...
67
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP02170
(
show subtarget assignments
)
1
soluble
No
FTT1010
56708100
helix-turn-helix family protein [Francis...
67
Drug Target
Phase 3: June 2008
3T75
29.9%
Francisella tularensis
Unknown function
General
IDP90131
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_144
68449218
cowpox A-type inclusion protein [Monkeyp...
67
similar to part of CPXV-GRI-A26L
Community Requests
Monkeypox virus
IDP00881
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1509
16764854
ydfZ
putative cytoplasmic protein
67
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP01111
(
show subtarget assignments
)
1
cloned
No
BA_1135
49035527
Major cold shock protein cspA
67
Conserved Gene / Pathway
Phase 2: March 2008
1CSP
73.1%
Bacillus anthracis
Cellular processes
Adaptations to atypical conditions
IDP05280
(
show subtarget assignments
)
1
soluble
No
CD0279A
126697852
hypothetical protein CD0279A [Clostridiu...
68
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP91464
(
show subtarget assignments
)
8
soluble
No
VV1_0086
27363570
P2-like prophage tail protein X [Vibrio ...
68
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP01108
(
show subtarget assignments
)
1
in_pdb
No
BA_3860
30258377
copper-ion-binding protein
68
Conserved Gene / Pathway
Phase 2: March 2008
2L3M
100%
Bacillus anthracis
Transport and binding proteins
Cations and iron carrying compounds
IDP00894
(
show subtarget assignments
)
1
expressed
No
STM4390
16767636
putative cytoplasmic protein
68
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP05653
(
show subtarget assignments
)
1
cloned
No
lmo0146
16802194
-
hypothetical protein lmo0146 [Listeria m...
68
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP01824
(
show subtarget assignments
)
1
cloned
No
STM3197
16766497
glgS
glycogen synthesis protein GlgS [Salmone...
69
Conserved; Drug target functions
Phase 3: June 2008
1RRZ
73.9%
Salmonella enterica
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP90181
(
show subtarget assignments
)
8
cloned
No
AAM13478.1
20153017
CPXV031 CDS
CPXV031 protein
69
kelch-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP00866
(
show subtarget assignments
)
1
cloned
No
STM3688
16766973
putative cytoplasmic protein
69
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP04328
(
show subtarget assignments
)
1
cloned
No
CPF_1452
110798743
cold shock protein [Clostridium perfring...
69
conserved gene; putative drug target function;
Phase 4: April 2009
2L15
56.3%
Clostridium perfringens
Cellular processes
Adaptations to atypical conditions
IDP00576
(
show subtarget assignments
)
1
cloned
No
YPO1398
16121678
cspB
cold shock-like protein
69
Virulence Associated Factor
Phase 2: March 2008
3I2Z
50.7%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP91413
(
show subtarget assignments
)
8
cloned
No
VV1_0714
27364169
hypothetical protein VV1_0714 [Vibrio vu...
69
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00891
(
show subtarget assignments
)
0
work_stopped
No
STM3816
16767101
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP90147
(
show subtarget assignments
)
8
cloned
No
MPXV_ZAI1979_005_194
68449266
kelch-like protein [Monkeypox virus]
70
similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R
Community Requests
2Q81
31.4%
Monkeypox virus
IDP05494
(
show subtarget assignments
)
1
soluble
No
CD0234
126697805
csrA
carbon storage regulator [Clostridium di...
70
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1T3O
47.1%
Clostridium difficile
Regulatory functions: RNA interactions
IDP00862
(
show subtarget assignments
)
1
cloned
No
STM2251
16765579
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP01732
(
show subtarget assignments
)
1
cloned
No
STM1243
16764598
cold shock-like protein [Salmonella typh...
70
Conserved; Drug target functions
Phase 3: June 2008
2L15
48.6%
Salmonella enterica
Unclassified
Role category not yet assigned
IDP05671
(
show subtarget assignments
)
1
soluble
No
lmo0725
16802767
-
peptidoglycan binding protein [Listeria ...
70
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Regulatory functions: Other
IDP04030
(
show subtarget assignments
)
1
cloned
No
YPO2532
115348229
hypothetical protein [Yersinia pestis CO...
70
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP05646
(
show subtarget assignments
)
1
soluble
No
CD3315A
126700935
hypothetical protein CD3315A [Clostridiu...
71
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP91471
(
show subtarget assignments
)
8
soluble
No
VPA1349
28901204
putative Type III secretion protein Spa3...
71
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP01021
(
show subtarget assignments
)
1
cloned
No
STM0044
16763434
yaaY
putative cytoplasmic protein
71
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP05457
(
show subtarget assignments
)
1
soluble
No
BA_1144
30254865
gerPF1
spore germination protein GerPF [Bacillu...
71
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP90148
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_195
68449267
serine protease inhibitor-like SPI-1 pro...
71
similar to part of VACV-COP-C12L, MPXV-ZAI96-B19R
Community Requests
Monkeypox virus
IDP91366
(
show subtarget assignments
)
8
cloned
No
VV1_2640
27365933
hypothetical protein VV1_2640 [Vibrio vu...
72
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP02148
(
show subtarget assignments
)
1
cloned
No
GBAA0133
47525389
infA
translation initiation factor IF-1 [Baci...
72
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1AH9
72.2%
Bacillus anthracis
Protein synthesis
Translation factors
IDP00621
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL2217
57284998
infA
translation initiation factor IF-1
72
Drug Target Function
Phase 2: March 2008
3I4O
69.9%
Staphylococcus aureus
Protein synthesis
Translation factors
IDP00602
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL0903
57285779
pathogenicity island protein
72
Conserved Gene / Pathway
Phase 2: March 2008
2L8T
95.8%
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP02092
(
show subtarget assignments
)
1
cloned
No
YPO0259
16120596
putative type III secretion apparatus [Y...
73
Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP05470
(
show subtarget assignments
)
1
expressed
No
BA_2451
30257081
conserved domain protein [Bacillus anthr...
74
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP00893
(
show subtarget assignments
)
1
soluble
No
STM4002
16767267
putative cytoplasmic protein
74
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP05347
(
show subtarget assignments
)
1
cloned
No
CD2364
126699979
hypothetical protein CD2364 [Clostridium...
74
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP05284
(
show subtarget assignments
)
1
expressed
No
CD0369
126697939
hypothetical protein CD0369 [Clostridium...
74
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP90319
(
show subtarget assignments
)
8
cloned
No
CT_753
3329214
hypothetical protein [Chlamydia trachoma...
74
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01621
(
show subtarget assignments
)
1
cloned
No
STM1984
16765321
yodD
putative cytoplasmic protein [Salmonella...
75
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP05675
(
show subtarget assignments
)
1
purified
No
lmo0953
16802993
-
hypothetical protein lmo0953 [Listeria m...
75
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91041
(
show subtarget assignments
)
8
in_pdb
3TYS
3TYR
No
EFE0002
33355847
vanUG
predicted transcriptional regulator [Ent...
75
drug resistance /
Putative transcriptional regulator
Community Requests
3T75
89.3%
Enterococcus faecalis
IDP00454
(
show subtarget assignments
)
1
expressed
No
YPO0133
16120476
feoA
ferrous iron transport protein A
75
Virulence Associated Factor
Phase 2: March 2008
2GCX
70.7%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP05462
(
show subtarget assignments
)
1
soluble
No
BA_1284
30255233
hypothetical protein BA_1284 [Bacillus a...
75
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP00992
(
show subtarget assignments
)
1
soluble
No
STM2227
16765556
yejL
putative cytoplasmic protein
75
Conserved Gene / Pathway
Phase 2: March 2008
2JRX
90.7%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP91557
(
show subtarget assignments
)
8
purified
No
BAB38065
13364117
ECs4642
hypothetical protein [Escherichia coli O...
76
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91320
(
show subtarget assignments
)
8
cloned
No
VV2_0303
27366747
hypothetical protein VV2_0303 [Vibrio vu...
76
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP01309
(
show subtarget assignments
)
1
purified
No
VC2078
15642078
ferrous iron transport protein A
76
Drug Target Function
Phase 2: March 2008
2K5I
34.2%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00888
(
show subtarget assignments
)
1
purified
No
STM2475
16765795
putative cytoplasmic protein
76
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP00859
(
show subtarget assignments
)
1
soluble
No
STM1770
16765111
chaB
cation transport regulator
76
Conserved Gene / Pathway
Phase 2: March 2008
1SG7
81.6%
Salmonella enterica
Transport and binding proteins
Unknown substrate
IDP91478
(
show subtarget assignments
)
8
cloned
No
VPA1335
28901190
putative type III secretion apparatus pr...
77
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP04663
(
show subtarget assignments
)
1
cloned
No
BAS5325
49188309
30S ribosomal protein S18 [Bacillus anth...
77
Proposed to be essential proteins
Phase 4: April 2009
1P6G
50.6%
Bacillus anthracis
IDP00890
(
show subtarget assignments
)
1
expressed
No
STM3720
16767005
yibR
putative inner membrane protein
77
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Cell envelope
Other
IDP02407
(
show subtarget assignments
)
1
cloned
No
GBAA3988
47529279
acpP
acyl carrier protein [Bacillus anthracis...
77
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2X2B
81.8%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01316
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC1616
15641624
glutaredoxin, putative
77
Conserved Gene / Pathway
Phase 2: March 2008
2KLX
32.5%
Vibrio cholerae
Energy metabolism
Electron transport
IDP02628
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM2923
16766229
putative cytoplasmic protein [Salmonella...
78
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP00620
(
show subtarget assignments
)
1
cloned
No
SACOL0937
57285812
dltC
D-alanine--poly(phosphoribitol) ligase s...
78
Conserved Gene / Pathway
Phase 2: March 2008
1DV5
41%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP01032
(
show subtarget assignments
)
1
soluble
No
STM3507
16766795
yhgG
putative cytoplasmic protein
78
Conserved Gene / Pathway
Phase 2: March 2008
1XN7
89.7%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP01025
(
show subtarget assignments
)
1
cloned
No
STM1196
16764551
acpP
acyl carrier protein
78
Conserved Gene / Pathway
Phase 2: March 2008
1L0H
100%
Salmonella enterica
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01696
(
show subtarget assignments
)
1
cloned
No
CBU_1767
29542324
feoA
ferrous iron transport protein A [Coxiel...
78
Conserved; Drug target functions
Phase 3: June 2008
2GCX
38.5%
Coxiella burnetii
Transport and binding proteins
Cations and iron carrying compounds
IDP01103
(
show subtarget assignments
)
1
cloned
No
BA_1387
47605671
D-alanine--poly(phosphoribitol) ligase s...
79
Drug Target Function
Phase 2: March 2008
1DV5
45.6%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01706
(
show subtarget assignments
)
1
cloned
No
STM1438
16764786
ydhL
putative oxidoreductase [Salmonella typh...
79
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP91747
(
show subtarget assignments
)
8
selected
No
Q8WLQ7_HUMAN
0
79
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1D5M
94.9%
Homo sapiens
IDP90333
(
show subtarget assignments
)
8
soluble
No
CT_606.1
3522903
hypothetical protein [Chlamydia trachoma...
79
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP05584
(
show subtarget assignments
)
1
soluble
No
BA_2341
30256978
gerPF2
spore germination protein GerPF [Bacillu...
79
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP91990
(
show subtarget assignments
)
8
selected
No
SpneCM_010100004332
298254829
ABC transporter substrate-binding protei...
80
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
1XT8
41.2%
Streptococcus pneumoniae
IDP01717
(
show subtarget assignments
)
1
cloned
No
Cj0968
15792296
putative periplasmic protein [Campylobac...
80
Predicted virulence-Adhesion of Campylobacter; Possible Vaccine Candidate
Phase 3: June 2008
Campylobacter jejuni
Cellular processes
Other
IDP05435
(
show subtarget assignments
)
1
cloned
No
BA_2837
30257439
hypothetical protein BA_2837 [Bacillus a...
80
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP00593
(
show subtarget assignments
)
1
expressed
No
YPO1232
16121518
msgA
putative stress response protein
80
Conserved Gene / Pathway
Phase 2: March 2008
1GHH
30.5%
Yersinia pestis
Cellular processes
Pathogenesis
IDP05725
(
show subtarget assignments
)
1
soluble
No
BA_3844
30258362
hypothetical protein BA_3844 [Bacillus a...
81
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP90514
(
show subtarget assignments
)
8
crystallized
No
Cj0513
15791875
phosphoribosylformylglycinamidine syntha...
81
Predicted Essential
Community Requests
1T4A
46.9%
Campylobacter jejuni
IDP05378
(
show subtarget assignments
)
1
soluble
No
BA_4133
30258639
hypothetical protein BA_4133 [Bacillus a...
81
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP01855
(
show subtarget assignments
)
1
soluble
No
STM1162
16764518
dinI
DNA damage-inducible protein I [Salmonel...
81
Conserved; Drug target functions
Phase 3: June 2008
1GHH
85.2%
Salmonella enterica
Unknown function
General
IDP04099
(
show subtarget assignments
)
1
expressed
No
VC1027
9655490
molybdenum cofactor biosynthesis protein...
81
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1FM0
70.4%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Molybdopterin
IDP02001
(
show subtarget assignments
)
1
cloned
No
YPO0261
16120599
putative type III secretion apparatus [Y...
82
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP01131
(
show subtarget assignments
)
1
in_pdb
3IHS
Yes
BA_5381
30259854
ptsH-2
phosphocarrier protein HPr
82
Conserved Gene / Pathway
Phase 2: March 2008
3IHS
100%
Bacillus anthracis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP91917
(
show subtarget assignments
)
8
selected
No
SpneCM_010100005808
298255110
hypothetical protein SpneCM_05808 [Strep...
82
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91489
(
show subtarget assignments
)
8
cloned
No
VP1694
28898468
type III export protein YscF [Vibrio par...
82
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2P58
51.2%
Vibrio parahaemolyticus
IDP01101
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO1_0119
47566439
hypothetical protein GBAA_pXO1_0119
82
Virulence Associated Factor
Phase 2: March 2008
3SIK
52.4%
Bacillus anthracis
IDP90135
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_174
68449246
kelch-like protein [Monkeypox virus]
82
similar to part of VACV-COP-A55R, MPXV-ZAI96-B1R
Community Requests
Monkeypox virus
IDP01026
(
show subtarget assignments
)
1
cloned
No
STM1267
16764618
putative cytoplasmic protein
82
Conserved Gene / Pathway
Phase 2: March 2008
2OXL
32.9%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP04039
(
show subtarget assignments
)
1
cloned
No
CPF_2446
110800060
spoIIID
stage III sporulation protein D [Clostri...
83
conserved gene; putative drug target function;
Phase 4: April 2009
2L0K
60.2%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP00874
(
show subtarget assignments
)
1
cloned
No
STM1275
16764626
yaoF
putative hemolysin
83
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Unknown function
General
IDP04391
(
show subtarget assignments
)
1
cloned
No
CPF_1067
110798883
cotJB
spore coat protein CotJB [Clostridium pe...
83
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP02034
(
show subtarget assignments
)
1
cloned
No
lmo0059
16802107
hypothetical protein lmo0059 [Listeria m...
83
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
2BPS
27.7%
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP05401
(
show subtarget assignments
)
1
expressed
No
BA_4365
30258863
hypothetical protein BA_4365 [Bacillus a...
83
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP01063
(
show subtarget assignments
)
1
soluble
No
STM3702
16766987
grxC
glutaredoxin 3
83
Conserved Gene / Pathway
Phase 2: March 2008
1FOV
86.7%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Glutathione and analogs
IDP90107
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_012
68449086
interleukin-1 receptor antagonist-like p...
83
similar to VACV-COP-C10L, MPXV-ZAI96-D4L
Community Requests
Monkeypox virus
IDP91439
(
show subtarget assignments
)
8
cloned
No
VV1_0471
27363938
ferredoxin [Vibrio vulnificus CMCP6]
84
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2ZVS
65.5%
Vibrio vulnificus
IDP90408
(
show subtarget assignments
)
8
expressed
No
CT_631
3329079
hypothetical protein [Chlamydia trachoma...
84
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02600
(
show subtarget assignments
)
1
expressed
No
STM2279
16765606
yfaE
2Fe-2S ferredoxin YfaE [Salmonella typhi...
84
Conserved; Drug target functions
Phase 3: June 2008
1IUE
37.2%
Salmonella enterica
Unknown function
General
IDP91826
(
show subtarget assignments
)
8
expressed
No
b2415
1788755
ptsH
phosphohistidinoprotein-hexose phosphotr...
85
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1GGR
100%
Escherichia coli
IDP01317
(
show subtarget assignments
)
1
soluble
No
VC0966
15640982
phosphocarrier protein HPr
85
Conserved Gene / Pathway
Phase 2: March 2008
1GGR
75.3%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP00416
(
show subtarget assignments
)
1
expressed
No
YPO1212
16121503
2Fe-2S ferredoxin YfaE
85
Conserved Gene / Pathway
Phase 2: March 2008
3AV8
33.3%
Yersinia pestis
Energy metabolism
Electron transport
IDP01801
(
show subtarget assignments
)
1
in_pdb
3MSZ
3LGC
No
FTT0533c
56707666
grxA
glutaredoxin 1 [Francisella tularensis s...
86
Drug Target
Phase 3: June 2008
3LGC
100%
Francisella tularensis
Energy metabolism
Electron transport
IDP05395
(
show subtarget assignments
)
1
cloned
No
BA_2942
30257534
putative lipoprotein [Bacillus anthracis...
86
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
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