Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01037 (show subtarget assignments)	0	work_stopped	No	STM2927	16766233	surE	stationary phase survival protein SurE	253	potential drug target / Conserved Gene / Pathway	Phase 2: March 2008	2V4N	100%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP01034 (show subtarget assignments)	0	work_stopped	No	STM4089	16767355	menG	ribonuclease activity regulator protein ...	161	Conserved Gene / Pathway	Phase 2: March 2008	1Q5X	97.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00993 (show subtarget assignments)	0	work_stopped	No	STM2250	16765578	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00990 (show subtarget assignments)	0	work_stopped	No	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00106 (show subtarget assignments)	0	work_stopped	No	NT01SF3707	30042635	mdaB	modulator of drug activity B	193	Virulence	Phase 1: October 2007	2AMJ	97.9%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00075 (show subtarget assignments)	0	work_stopped	No	NTL01ST3174	16421824	yraO	putative phosphoheptose isomerase	196		Phase 1: October 2007	2YVA	98%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00906 (show subtarget assignments)	0	work_stopped	No	STM0129	16763519	murC	UDP-N-acetylmuramate--L-alanine ligase	491	Essential Gene	Phase 2: March 2008	2F00	94.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905 (show subtarget assignments)	0	work_stopped	No	STM0126	16763516	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	438	Essential Gene	Phase 2: March 2008	1E0D	92.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00055 (show subtarget assignments)	0	work_stopped	No	BA_3696	30258217		blasticidin S deaminase, putative	142	Virulence	Phase 1: October 2007	3B8F	99.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00018 (show subtarget assignments)	0	work_stopped	No	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00007 (show subtarget assignments)	0	work_stopped	No	BA_0847	30254435	racE-1	glutamate racemase	276	Drug Target Homolog	Phase 1: October 2007	2DWU	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00063 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4952	30259447		aminoglycoside phosphotransferase family...	263	Virulence	Phase 1: October 2007	3I0O	14.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00062 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4511	50400989		4-hydroxy-3-methylbut-2-enyl diphosphate...	316	Virulence	Phase 1: October 2007	3F7T	35.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00031 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1078	30254808	blaI	penicillinase repressor	132	Virulence	Phase 1: October 2007	1OKR	35.6%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00061 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4399	30258896		hemolysin A	279	Virulence	Phase 1: October 2007	3HP7	58.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00121 (show subtarget assignments)	1	in_pdb 3DQQ	No	NT01ST3629	16766223	ygbK	putative tRNA synthase	420	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DQQ	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00120 (show subtarget assignments)	1	expressed	No	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP00060 (show subtarget assignments)	1	in_pdb 3UH9	Yes	BA_4109	46395774		Metallothiol transferase fosB 2 (Fosfomy...	139	Virulence	Phase 1: October 2007	3UH9	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00030 (show subtarget assignments)	1	purified	No	BA_0926	30254669		tellurium resistance protein, putative	401	Virulence	Phase 1: October 2007	2KXT	16%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00015 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4048	47605856		UDP-N-acetylenolpyruvoylglucosamine redu...	301	Drug Target Homolog	Phase 1: October 2007	1HSK	39.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00122 (show subtarget assignments)	1	in_pdb 3CWC	Yes	NT01ST3693	16766265	STM2959	putative glycerate kinase 2	380	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3CWC	100%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP00118 (show subtarget assignments)	1	in_pdb 3MGA	No	NT01ST0713	16763963	fes	enterobactin/ferric enterobactin esteras...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3MGA	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00126 (show subtarget assignments)	1	soluble	No	NT01ST1449	16764525	mviM	putative virulence protein	307	Virulence	Phase 1: October 2007	1TLT	81.4%	Salmonella enterica	Cellular processes	Pathogenesis

IDP00127 (show subtarget assignments)	1	soluble	No	NT01ST1705	16764721	sufC	cysteine desulfurase ATPase component	248	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2D3W	92.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00059 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4013	30258522		fibronectin/fibrinogen-binding protein, ...	569	Virulence	Phase 1: October 2007	3DOA	22.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP00117 (show subtarget assignments)	1	purified	No	NT01ST0298	16763632	yaeB	putative regulatory protein	235	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1XQB	47.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00058 (show subtarget assignments)	1	soluble	No	BA_3903	30258417		bacteriocin ABC transporter, ATP-binding...	234	Virulence	Phase 1: October 2007	1OXS	32.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00029 (show subtarget assignments)	1	purified	No	BA_0404	30253939		tellurite resistance protein, putative	360	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00115 (show subtarget assignments)	1	crystallized	No	NT01VPA0514	28900406	VPA0551	hypothetical protein VPA0551 (gi 2890040...	181	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2OT9	33.7%	Vibrio parahaemolyticus	Cellular processes	Toxin production and resistance

IDP00114 (show subtarget assignments)	1	purified	No	GVCV52ORF0478	9654887		Vibrio cholerae O1 biovar eltor str. N16...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3JVU	65.8%	Vibrio cholerae	Cell envelope	Surface structures

IDP00057 (show subtarget assignments)	1	soluble	No	BA_3900	30258414		lantibiotic biosynthesis DNA-binding res...	220	Virulence	Phase 1: October 2007	2GWR	34.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00112 (show subtarget assignments)	1	soluble	No	NT01SF5194	30043810	hflK	protease specific for phage lambda cII r...	419	Essential	Phase 1: October 2007	3BK6	11%	Shigella flexneri	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00056 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3898	30258412		choloylglycine hydrolase family protein ...	328	Virulence	Phase 1: October 2007	2OQC	48.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00028 (show subtarget assignments)	1	purified	No	BA_0401	30253936		tellurium resistance protein	194	Virulence	Phase 1: October 2007	2KXT	57.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00014 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3915	17368674		Protein recA (Recombinase A)	343	Drug Target Homolog	Phase 1: October 2007	1UBC	65.6%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP00111 (show subtarget assignments)	1	in_pdb 3TV9	No	NT02SF4808	30043741	pmbA	putative peptide maturation protein	450	Virulence	Phase 1: October 2007	3TV9	96.2%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00110 (show subtarget assignments)	1	purified	No	NT01SF4145	30043548	glgC	glucose-1-phosphate adenylyltransferase ...	431	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3BRK	55.2%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00109 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF4517	30043269	recF	Rec protein	357	Essential	Phase 1: October 2007	2O5V	27.2%	Shigella flexneri	DNA metabolism	DNA replication, recombination, and repair

IDP00108 (show subtarget assignments)	1	purified	No	NT01SF4751	30043076	fdhE	FdhE protein	309	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FIY	39.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00054 (show subtarget assignments)	1	crystallized	No	BA_3600	30258128		acetyltransferase, CYSE/LACA/LPXA/NODL f...	185	Virulence	Phase 1: October 2007	1KHR	42.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00027 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0400	30253935		tellurium resistance protein	194	Virulence	Phase 1: October 2007	2KXT	56.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00107 (show subtarget assignments)	1	in_pdb 3DR3	No	NT01SF4834	30043015	argC	N-acetyl-gamma-glutamylphosphate reducta...	334	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DR3	100%	Shigella flexneri	Amino acid biosynthesis	Glutamate family

IDP00053 (show subtarget assignments)	1	soluble	No	BA_3536	30258071		phenazine biosynthesis protein, PhzF fam...	285	Virulence	Phase 1: October 2007	1QY9	31.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00105 (show subtarget assignments)	1	purified	No	NT01SF3662	30042589	S3225	putative class II aminotransferase	116	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2X8U	40.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00104 (show subtarget assignments)	1	purified	No	NT01SF3305	30042319	srlB	PTS system, glucitol/sorbitol-specific e...	123	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2F9H	25.2%	Shigella flexneri	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00052 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3500	30258038	bla2	beta-lactamase II	256	Virulence	Phase 1: October 2007	1BC2	81.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00026 (show subtarget assignments)	1	soluble	No	BA_0399	30253934		tellurium resistance protein, putative	198	Virulence	Phase 1: October 2007	3IBZ	41.9%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00013 (show subtarget assignments)	1	soluble	No	BA_3254	30257811		LPXTG-motif cell wall anchor domain prot...	372	Drug Target Homolog	Phase 1: October 2007	1I84	18.3%	Bacillus anthracis	Cell envelope	Other

IDP00103 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF3270	30042295	ygaC	hypothetical protein S2885	114	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2G7J	86.8%	Shigella flexneri	Cell envelope	Other

IDP00102 (show subtarget assignments)	1	crystallized	No	NT01SF2944	30042031	evgA	putative positive transcription regulato...	204	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3F6C	64.7%	Shigella flexneri	Cell envelope	Surface structures

IDP00051 (show subtarget assignments)	1	in_pdb 3EDN	Yes	BA_3469	30258008		phenazine biosynthesis protein, PhzF fam...	299	Virulence	Phase 1: October 2007	3EDN	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00101 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF2638	30041803	mrp	putative ATPase	369	Essential	Phase 1: October 2007	2PH1	27.1%	Shigella flexneri	Unknown function	General

IDP00202 (show subtarget assignments)	1	soluble	No	YPO2731	16122935	-	putative membrane protein	679	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00050 (show subtarget assignments)	1	cloned	No	BA_3443	30257983		enhancin family protein	742	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Pathogenesis

IDP00025 (show subtarget assignments)	1	purified	No	BA_0285	30253779		bacitracin ABC transporter, ATP-binding ...	309	Virulence	Phase 1: October 2007	1OXS	30.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00200 (show subtarget assignments)	1	expressed	No	YPO1473	16121748	-	hypothetical protein	766	Virulence	Phase 1: October 2007			Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00198 (show subtarget assignments)	1	cloned	No	YPO1367	16121647	-	conserved hypothetical protein	106	Similar to Essential SALTY	Phase 1: October 2007	1MBU	84.9%	Yersinia pestis

IDP00098 (show subtarget assignments)	1	soluble	No	NT01SF2011	30041408	slyA	transcriptional regulator	146	Virulence	Phase 1: October 2007	3DEU	88.4%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00097 (show subtarget assignments)	1	expressed	No	NTL02SF1117	30040935	S1242	hypothetical protein S1242	773	Virulence	Phase 1: October 2007	3QQ2	9.8%	Shigella flexneri	Cellular processes	Pathogenesis

IDP00096 (show subtarget assignments)	1	in_crystallization_trials	No	NTL02SF1070	30040886	ycfO	hypothetical protein S1191	341	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1TR9	55.7%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00048 (show subtarget assignments)	1	cloned	No	BA_3330	30257875		beta-lactam antibiotic acylase family pr...	796	Virulence	Phase 1: October 2007	1KEH	22.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00024 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0039	33516921		Dimethyladenosine transferase (S-adenosy...	292	Virulence	Phase 1: October 2007	3GRR	37.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00012 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2953	61211623		3-phosphoshikimate 1-carboxyvinyltransfe...	429	Drug Target Homolog	Phase 1: October 2007	3RMT	66.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00006 (show subtarget assignments)	1	soluble	No	BA_0672	30254271		immune inhibitor A metalloprotease	799	Virulence/Drug Target Homolog	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00003 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0158	47566470	gerXC	spore germination protein xc, (pxo1-112)...	317	Drug Target Homolog	Phase 1: October 2007			Bacillus anthracis

IDP00095 (show subtarget assignments)	1	purified	No	NT01SF1278	30040854	flgN	flagella synthesis protein FlgN	138	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007			Shigella flexneri	Cell envelope	Surface structures

IDP00190 (show subtarget assignments)	1	soluble	No	YPO0927	16121232	-	putative lipoprotein	250	Similar to Essential SALTY	Phase 1: October 2007	3C37	23.6%	Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00047 (show subtarget assignments)	1	in_pdb 3PP9	No	BA_3185	30257752		streptothricin acetyltransferase, putati...	184	Virulence	Phase 1: October 2007	3PP9	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00093 (show subtarget assignments)	1	expressed	No	NT01SF0510	30040252	ybbF	hypothetical protein S0463	240	Essential	Phase 1: October 2007			Shigella flexneri	Unknown function	General

IDP00092 (show subtarget assignments)	1	expressed	No	NT01SF0466	30040219	hemH	ferrochelatase	320	Essential	Phase 1: October 2007	1L8X	27.9%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00046 (show subtarget assignments)	1	in_pdb 3FOB	Yes	BA_3165	30257736		bromoperoxidase	278	Virulence	Phase 1: October 2007	3FOB	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00023 (show subtarget assignments)	1	cloned	No	BA_5594	30260051	papR	PapR	48	Drug Target Homolog	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Pathogenesis

IDP00184 (show subtarget assignments)	1	cloned	No	YPO0624	16120950	-	putative membrane protein	483	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00183 (show subtarget assignments)	1	cloned	No	YPO0613	16120939	-	putative permease protein	293	Virulence	Phase 1: October 2007	2R6G	22.5%	Yersinia pestis

IDP00182 (show subtarget assignments)	1	soluble	No	YPO0398	16120732	-	M48 peptidase family protein	348	Similar to Essential SALTY	Phase 1: October 2007	3C37	10.1%	Yersinia pestis	Protein synthesis	Translation factors

IDP00090 (show subtarget assignments)	1	crystallized	No	NT01SF0319	30040101	crl	transcriptional regulator of cryptic csg...	133	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3RPJ	45.9%	Shigella flexneri	Cell envelope	Surface structures

IDP00045 (show subtarget assignments)	1	purified	No	BA_3111	30257692		aminoglycoside phosphotransferase family...	292	Virulence	Phase 1: October 2007	3LZH	17.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00181 (show subtarget assignments)	1	soluble	No	YPO0363	16120698	-	putative membrane transport protein	1119	Similar to Essential SALTY	Phase 1: October 2007	2OAU	5%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP00180 (show subtarget assignments)	1	expressed	No	YPO0339	16120675	-	enhancing factor (viral)	856	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00185 (show subtarget assignments)	1	cloned	No	YPO0639	16120963	-	hypothetical protein	460	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00186 (show subtarget assignments)	1	soluble	No	YPO0695	16121016	-	putative membrane protein	140	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00187 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0773	16121086	-	putative thioesterase	254	Virulence	Phase 1: October 2007	3FLA	30.3%	Yersinia pestis	Regulatory functions	Other

IDP00188 (show subtarget assignments)	1	purified	No	YPO0806	16121118	-	prepilin peptidase	280	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00189 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0845	16121153	-	ThiJ/PfpI-family thiamine biogenesis pro...	192	Virulence	Phase 1: October 2007	1J42	29.2%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00179 (show subtarget assignments)	1	cloned	No	YPO0277	16120616	-	putative transmembrane transport protein...	428	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00191 (show subtarget assignments)	1	cloned	No	YPO0932	16121236	-	conserved hypothetical protein	170	Virulence	Phase 1: October 2007			Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP00192 (show subtarget assignments)	1	cloned	No	YPO0947	16121251	-	putative virulence determinant	3110	Virulence	Phase 1: October 2007	1AF0	2.9%	Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP00193 (show subtarget assignments)	1	expressed	No	YPO0966	16121269	-	putative kinase	765	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00194 (show subtarget assignments)	1	cloned	No	YPO0983	16121287	-	putative membrane protein	216	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00195 (show subtarget assignments)	1	cloned	No	YPO1009	16121311	-	probable peptidase	410	Similar to Essential SALTY	Phase 1: October 2007	1VIX	38%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00196 (show subtarget assignments)	1	cloned	No	YPO1051	16121351	-	putative membrane protein	451	Virulence	Phase 1: October 2007	2ZPL	13.5%	Yersinia pestis

IDP00197 (show subtarget assignments)	1	purified	No	YPO1233	16121519	-	putative prophage repressor protein	240	Similar to Essential SALTY	Phase 1: October 2007	3BDN	46.2%	Yersinia pestis

IDP00178 (show subtarget assignments)	1	soluble	No	YPO3405	16123554	-	putative ABC transporter, integral membr...	256	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00199 (show subtarget assignments)	1	purified	No	YPO1431	16121710	-	putative Lon protease	590	Virulence	Phase 1: October 2007	3K1J	17.6%	Yersinia pestis	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP00044 (show subtarget assignments)	1	in_pdb 3SLB 3SLF 3E4F 3IJW 3N0S 3KZL 3N0M	Yes	BA_2930	30257522	aacC7	aminoglycoside N3-acetyltransferase	265	Virulence	Phase 1: October 2007	3E4F	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00201 (show subtarget assignments)	1	expressed	No	YPO1476	16121751	-	hypothetical protein	727	Virulence	Phase 1: October 2007			Yersinia pestis	Energy metabolism	Photosynthesis

IDP00022 (show subtarget assignments)	1	cloned	No	BA_5578	81714842		UDP-N-acetylglucosamine 1-carboxyvinyltr...	429	Drug Target Homolog	Phase 1: October 2007	3SG1	49.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00011 (show subtarget assignments)	1	soluble	No	BA_2222	30256868		alcohol dehydrogenase, iron-containing	392	Drug Target Homolog	Phase 1: October 2007	3OWO	37.8%	Bacillus anthracis	Energy metabolism	Fermentation

IDP01037
(show subtarget assignments)

0

work_stopped

No

STM2927

16766233

surE

stationary phase survival protein SurE

253

potential drug target / Conserved Gene / Pathway

Phase 2: March 2008

2V4N

100%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP01034
(show subtarget assignments)

0

work_stopped

No

STM4089

16767355

menG

ribonuclease activity regulator protein ...

161

Conserved Gene / Pathway

Phase 2: March 2008

1Q5X

97.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00993
(show subtarget assignments)

0

work_stopped

No

STM2250

16765578

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00990
(show subtarget assignments)

0

work_stopped

No

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00106
(show subtarget assignments)

0

work_stopped

No

NT01SF3707

30042635

mdaB

modulator of drug activity B

193

Virulence

Phase 1: October 2007

2AMJ

97.9%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00075
(show subtarget assignments)

0

work_stopped

No

NTL01ST3174

16421824

yraO

putative phosphoheptose isomerase

196

Phase 1: October 2007

2YVA

98%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00906
(show subtarget assignments)

0

work_stopped

No

STM0129

16763519

murC

UDP-N-acetylmuramate--L-alanine ligase

491

Essential Gene

Phase 2: March 2008

2F00

94.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00905
(show subtarget assignments)

0

work_stopped

No

STM0126

16763516

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

438

Essential Gene

Phase 2: March 2008

1E0D

92.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00055
(show subtarget assignments)

0

work_stopped

No

BA_3696

30258217

blasticidin S deaminase, putative

142

Virulence

Phase 1: October 2007

3B8F

99.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00018
(show subtarget assignments)

0

work_stopped

No

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00007
(show subtarget assignments)

0

work_stopped

No

BA_0847

30254435

racE-1

glutamate racemase

276

Drug Target Homolog

Phase 1: October 2007

2DWU

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00063
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4952

30259447

aminoglycoside phosphotransferase family...

263

Virulence

Phase 1: October 2007

3I0O

14.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00062
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4511

50400989

4-hydroxy-3-methylbut-2-enyl diphosphate...

316

Virulence

Phase 1: October 2007

3F7T

35.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00031
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1078

30254808

blaI

penicillinase repressor

132

Virulence

Phase 1: October 2007

1OKR

35.6%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00061
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4399

30258896

hemolysin A

279

Virulence

Phase 1: October 2007

3HP7

58.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00121
(show subtarget assignments)

1

in_pdb
3DQQ

No

NT01ST3629

16766223

ygbK

putative tRNA synthase

420

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DQQ

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00120
(show subtarget assignments)

1

expressed

No

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP00060
(show subtarget assignments)

1

in_pdb
3UH9

Yes

BA_4109

46395774

Metallothiol transferase fosB 2 (Fosfomy...

139

Virulence

Phase 1: October 2007

3UH9

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00030
(show subtarget assignments)

1

purified

No

BA_0926

30254669

tellurium resistance protein, putative

401

Virulence

Phase 1: October 2007

2KXT

16%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00015
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4048

47605856

UDP-N-acetylenolpyruvoylglucosamine redu...

301

Drug Target Homolog

Phase 1: October 2007

1HSK

39.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00122
(show subtarget assignments)

1

in_pdb
3CWC

Yes

NT01ST3693

16766265

STM2959

putative glycerate kinase 2

380

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3CWC

100%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP00118
(show subtarget assignments)

1

in_pdb
3MGA

No

NT01ST0713

16763963

fes

enterobactin/ferric enterobactin esteras...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3MGA

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00126
(show subtarget assignments)

1

soluble

No

NT01ST1449

16764525

mviM

putative virulence protein

307

Virulence

Phase 1: October 2007

1TLT

81.4%

Salmonella enterica

Cellular processes

Pathogenesis

IDP00127
(show subtarget assignments)

1

soluble

No

NT01ST1705

16764721

sufC

cysteine desulfurase ATPase component

248

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2D3W

92.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00059
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4013

30258522

fibronectin/fibrinogen-binding protein, ...

569

Virulence

Phase 1: October 2007

3DOA

22.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00117
(show subtarget assignments)

1

purified

No

NT01ST0298

16763632

yaeB

putative regulatory protein

235

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1XQB

47.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00058
(show subtarget assignments)

1

soluble

No

BA_3903

30258417

bacteriocin ABC transporter, ATP-binding...

234

Virulence

Phase 1: October 2007

1OXS

32.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00029
(show subtarget assignments)

1

purified

No

BA_0404

30253939

tellurite resistance protein, putative

360

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00115
(show subtarget assignments)

1

crystallized

No

NT01VPA0514

28900406

VPA0551

hypothetical protein VPA0551 (gi 2890040...

181

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2OT9

33.7%

Vibrio parahaemolyticus

Cellular processes

Toxin production and resistance

IDP00114
(show subtarget assignments)

1

purified

No

GVCV52ORF0478

9654887

Vibrio cholerae O1 biovar eltor str. N16...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3JVU

65.8%

Vibrio cholerae

Cell envelope

Surface structures

IDP00057
(show subtarget assignments)

1

soluble

No

BA_3900

30258414

lantibiotic biosynthesis DNA-binding res...

220

Virulence

Phase 1: October 2007

2GWR

34.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00112
(show subtarget assignments)

1

soluble

No

NT01SF5194

30043810

hflK

protease specific for phage lambda cII r...

419

Essential

Phase 1: October 2007

3BK6

11%

Shigella flexneri

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00056
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3898

30258412

choloylglycine hydrolase family protein ...

328

Virulence

Phase 1: October 2007

2OQC

48.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00028
(show subtarget assignments)

1

purified

No

BA_0401

30253936

tellurium resistance protein

194

Virulence

Phase 1: October 2007

2KXT

57.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00014
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3915

17368674

Protein recA (Recombinase A)

343

Drug Target Homolog

Phase 1: October 2007

1UBC

65.6%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP00111
(show subtarget assignments)

1

in_pdb
3TV9

No

NT02SF4808

30043741

pmbA

putative peptide maturation protein

450

Virulence

Phase 1: October 2007

3TV9

96.2%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00110
(show subtarget assignments)

1

purified

No

NT01SF4145

30043548

glgC

glucose-1-phosphate adenylyltransferase ...

431

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3BRK

55.2%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00109
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF4517

30043269

recF

Rec protein

357

Essential

Phase 1: October 2007

2O5V

27.2%

Shigella flexneri

DNA metabolism

DNA replication, recombination, and repair

IDP00108
(show subtarget assignments)

1

purified

No

NT01SF4751

30043076

fdhE

FdhE protein

309

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FIY

39.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00054
(show subtarget assignments)

1

crystallized

No

BA_3600

30258128

acetyltransferase, CYSE/LACA/LPXA/NODL f...

185

Virulence

Phase 1: October 2007

1KHR

42.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00027
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0400

30253935

tellurium resistance protein

194

Virulence

Phase 1: October 2007

2KXT

56.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00107
(show subtarget assignments)

1

in_pdb
3DR3

No

NT01SF4834

30043015

argC

N-acetyl-gamma-glutamylphosphate reducta...

334

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DR3

100%

Shigella flexneri

Amino acid biosynthesis

Glutamate family

IDP00053
(show subtarget assignments)

1

soluble

No

BA_3536

30258071

phenazine biosynthesis protein, PhzF fam...

285

Virulence

Phase 1: October 2007

1QY9

31.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00105
(show subtarget assignments)

1

purified

No

NT01SF3662

30042589

S3225

putative class II aminotransferase

116

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2X8U

40.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00104
(show subtarget assignments)

1

purified

No

NT01SF3305

30042319

srlB

PTS system, glucitol/sorbitol-specific e...

123

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2F9H

25.2%

Shigella flexneri

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00052
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3500

30258038

bla2

beta-lactamase II

256

Virulence

Phase 1: October 2007

1BC2

81.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00026
(show subtarget assignments)

1

soluble

No

BA_0399

30253934

tellurium resistance protein, putative

198

Virulence

Phase 1: October 2007

3IBZ

41.9%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00013
(show subtarget assignments)

1

soluble

No

BA_3254

30257811

LPXTG-motif cell wall anchor domain prot...

372

Drug Target Homolog

Phase 1: October 2007

1I84

18.3%

Bacillus anthracis

Cell envelope

Other

IDP00103
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF3270

30042295

ygaC

hypothetical protein S2885

114

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2G7J

86.8%

Shigella flexneri

Cell envelope

Other

IDP00102
(show subtarget assignments)

1

crystallized

No

NT01SF2944

30042031

evgA

putative positive transcription regulato...

204

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3F6C

64.7%

Shigella flexneri

Cell envelope

Surface structures

IDP00051
(show subtarget assignments)

1

in_pdb
3EDN

Yes

BA_3469

30258008

phenazine biosynthesis protein, PhzF fam...

299

Virulence

Phase 1: October 2007

3EDN

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00101
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF2638

30041803

mrp

putative ATPase

369

Essential

Phase 1: October 2007

2PH1

27.1%

Shigella flexneri

Unknown function

General

IDP00202
(show subtarget assignments)

1

soluble

No

YPO2731

16122935

-

putative membrane protein

679

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00050
(show subtarget assignments)

1

cloned

No

BA_3443

30257983

enhancin family protein

742

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00025
(show subtarget assignments)

1

purified

No

BA_0285

30253779

bacitracin ABC transporter, ATP-binding ...

309

Virulence

Phase 1: October 2007

1OXS

30.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00200
(show subtarget assignments)

1

expressed

No

YPO1473

16121748

-

hypothetical protein

766

Virulence

Phase 1: October 2007

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00198
(show subtarget assignments)

1

cloned

No

YPO1367

16121647

-

conserved hypothetical protein

106

Similar to Essential SALTY

Phase 1: October 2007

1MBU

84.9%

Yersinia pestis

IDP00098
(show subtarget assignments)

1

soluble

No

NT01SF2011

30041408

slyA

transcriptional regulator

146

Virulence

Phase 1: October 2007

3DEU

88.4%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00097
(show subtarget assignments)

1

expressed

No

NTL02SF1117

30040935

S1242

hypothetical protein S1242

773

Virulence

Phase 1: October 2007

3QQ2

9.8%

Shigella flexneri

Cellular processes

Pathogenesis

IDP00096
(show subtarget assignments)

1

in_crystallization_trials

No

NTL02SF1070

30040886

ycfO

hypothetical protein S1191

341

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1TR9

55.7%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00048
(show subtarget assignments)

1

cloned

No

BA_3330

30257875

beta-lactam antibiotic acylase family pr...

796

Virulence

Phase 1: October 2007

1KEH

22.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00024
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0039

33516921

Dimethyladenosine transferase (S-adenosy...

292

Virulence

Phase 1: October 2007

3GRR

37.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00012
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2953

61211623

3-phosphoshikimate 1-carboxyvinyltransfe...

429

Drug Target Homolog

Phase 1: October 2007

3RMT

66.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00006
(show subtarget assignments)

1

soluble

No

BA_0672

30254271

immune inhibitor A metalloprotease

799

Virulence/Drug Target Homolog

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00003
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0158

47566470

gerXC

spore germination protein xc, (pxo1-112)...

317

Drug Target Homolog

Phase 1: October 2007

Bacillus anthracis

IDP00095
(show subtarget assignments)

1

purified

No

NT01SF1278

30040854

flgN

flagella synthesis protein FlgN

138

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

Shigella flexneri

Cell envelope

Surface structures

IDP00190
(show subtarget assignments)

1

soluble

No

YPO0927

16121232

-

putative lipoprotein

250

Similar to Essential SALTY

Phase 1: October 2007

3C37

23.6%

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00047
(show subtarget assignments)

1

in_pdb
3PP9

No

BA_3185

30257752

streptothricin acetyltransferase, putati...

184

Virulence

Phase 1: October 2007

3PP9

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00093
(show subtarget assignments)

1

expressed

No

NT01SF0510

30040252

ybbF

hypothetical protein S0463

240

Essential

Phase 1: October 2007

Shigella flexneri

Unknown function

General

IDP00092
(show subtarget assignments)

1

expressed

No

NT01SF0466

30040219

hemH

ferrochelatase

320

Essential

Phase 1: October 2007

1L8X

27.9%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00046
(show subtarget assignments)

1

in_pdb
3FOB

Yes

BA_3165

30257736

bromoperoxidase

278

Virulence

Phase 1: October 2007

3FOB

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00023
(show subtarget assignments)

1

cloned

No

BA_5594

30260051

papR

PapR

48

Drug Target Homolog

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00184
(show subtarget assignments)

1

cloned

No

YPO0624

16120950

-

putative membrane protein

483

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00183
(show subtarget assignments)

1

cloned

No

YPO0613

16120939

-

putative permease protein

293

Virulence

Phase 1: October 2007

2R6G

22.5%

Yersinia pestis

IDP00182
(show subtarget assignments)

1

soluble

No

YPO0398

16120732

-

M48 peptidase family protein

348

Similar to Essential SALTY

Phase 1: October 2007

3C37

10.1%

Yersinia pestis

Protein synthesis

Translation factors

IDP00090
(show subtarget assignments)

1

crystallized

No

NT01SF0319

30040101

crl

transcriptional regulator of cryptic csg...

133

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3RPJ

45.9%

Shigella flexneri

Cell envelope

Surface structures

IDP00045
(show subtarget assignments)

1

purified

No

BA_3111

30257692

aminoglycoside phosphotransferase family...

292

Virulence

Phase 1: October 2007

3LZH

17.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00181
(show subtarget assignments)

1

soluble

No

YPO0363

16120698

-

putative membrane transport protein

1119

Similar to Essential SALTY

Phase 1: October 2007

2OAU

5%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP00180
(show subtarget assignments)

1

expressed

No

YPO0339

16120675

-

enhancing factor (viral)

856

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00185
(show subtarget assignments)

1

cloned

No

YPO0639

16120963

-

hypothetical protein

460

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00186
(show subtarget assignments)

1

soluble

No

YPO0695

16121016

-

putative membrane protein

140

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00187
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0773

16121086

-

putative thioesterase

254

Virulence

Phase 1: October 2007

3FLA

30.3%

Yersinia pestis

Regulatory functions

Other

IDP00188
(show subtarget assignments)

1

purified

No

YPO0806

16121118

-

prepilin peptidase

280

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00189
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0845

16121153

-

ThiJ/PfpI-family thiamine biogenesis pro...

192

Virulence

Phase 1: October 2007

1J42

29.2%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00179
(show subtarget assignments)

1

cloned

No

YPO0277

16120616

-

putative transmembrane transport protein...

428

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00191
(show subtarget assignments)

1

cloned

No

YPO0932

16121236

-

conserved hypothetical protein

170

Virulence

Phase 1: October 2007

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP00192
(show subtarget assignments)

1

cloned

No

YPO0947

16121251

-

putative virulence determinant

3110

Virulence

Phase 1: October 2007

1AF0

2.9%

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP00193
(show subtarget assignments)

1

expressed

No

YPO0966

16121269

-

putative kinase

765

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00194
(show subtarget assignments)

1

cloned

No

YPO0983

16121287

-

putative membrane protein

216

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00195
(show subtarget assignments)

1

cloned

No

YPO1009

16121311

-

probable peptidase

410

Similar to Essential SALTY

Phase 1: October 2007

1VIX

38%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00196
(show subtarget assignments)

1

cloned

No

YPO1051

16121351

-

putative membrane protein

451

Virulence

Phase 1: October 2007

2ZPL

13.5%

Yersinia pestis

IDP00197
(show subtarget assignments)

1

purified

No

YPO1233

16121519

-

putative prophage repressor protein

240

Similar to Essential SALTY

Phase 1: October 2007

3BDN

46.2%

Yersinia pestis

IDP00178
(show subtarget assignments)

1

soluble

No

YPO3405

16123554

-

putative ABC transporter, integral membr...

256

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00199
(show subtarget assignments)

1

purified

No

YPO1431

16121710

-

putative Lon protease

590

Virulence

Phase 1: October 2007

3K1J

17.6%

Yersinia pestis

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP00044
(show subtarget assignments)

1

in_pdb
3SLB
3SLF
3E4F
3IJW
3N0S
3KZL
3N0M

Yes

BA_2930

30257522

aacC7

aminoglycoside N3-acetyltransferase

265

Virulence

Phase 1: October 2007

3E4F

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00201
(show subtarget assignments)

1

expressed

No

YPO1476

16121751

-

hypothetical protein

727

Virulence

Phase 1: October 2007

Yersinia pestis

Energy metabolism

Photosynthesis

IDP00022
(show subtarget assignments)

1

cloned

No

BA_5578

81714842

UDP-N-acetylglucosamine 1-carboxyvinyltr...

429

Drug Target Homolog

Phase 1: October 2007

3SG1

49.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00011
(show subtarget assignments)

1

soluble

No

BA_2222

30256868

alcohol dehydrogenase, iron-containing

392

Drug Target Homolog

Phase 1: October 2007

3OWO

37.8%

Bacillus anthracis

Energy metabolism

Fermentation

Targets