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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90818
(
show subtarget assignments
)
8
expressed
No
YPO1059
16121359
dnaE
DNA polymerase III subunit alpha [Yersin...
1171
Predicted Essential
Community Requests
2HQA
70%
Yersinia pestis
IDP90292
(
show subtarget assignments
)
8
cloned
No
TGGT1_004130
221483205
histone acetyltransferase GCN5, putative...
1169
The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...
Community Requests
1Z4R
8.5%
Toxoplasma gondii
IDP90928
(
show subtarget assignments
)
8
soluble
No
VC2245
15642243
dnaE
DNA polymerase III subunit alpha [Vibrio...
1164
Predicted Essential
Community Requests
2HQA
62.5%
Vibrio cholerae
IDP90273
(
show subtarget assignments
)
8
cloned
No
TGME49_013900
211968791
regulator of chromosome condensation, pu...
1155
Signature-tagged mutagenesis (STM) has identified the regulator of chromosome co...
Community Requests
3MVD
11.1%
Toxoplasma gondii
IDP05082
(
show subtarget assignments
)
1
cloned
No
lmo2179
16804218
-
peptidoglycan binding protein [Listeria ...
1152
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KT7
2.3%
Listeria monocytogenes
Regulatory functions: Other
IDP04729
(
show subtarget assignments
)
1
cloned
No
YPO0515
115346325
putative membrane protein [Yersinia pest...
1150
virulence factor; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91674
(
show subtarget assignments
)
8
selected
No
CGA1_HELPY
0
1147
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3IEC
6.9%
Helicobacter pylori
IDP04166
(
show subtarget assignments
)
1
cloned
No
VC1653
15641658
sensory box sensor histidine kinase/resp...
1146
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
6.6%
Vibrio cholerae
Regulatory functions
Other
IDP04460
(
show subtarget assignments
)
1
expressed
No
YPO1482
115347233
putative membrane protein [Yersinia pest...
1140
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Cell envelope
Other
IDP90099
(
show subtarget assignments
)
8
cloned
No
ZZZ_0015
1137
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP05431
(
show subtarget assignments
)
1
cloned
No
lmo1224
16803264
-
hypothetical protein lmo1224 [Listeria m...
1136
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Transport and binding proteins: Amino acids, peptides and amines
IDP91717
(
show subtarget assignments
)
8
selected
No
NP_054706
7669550
VCL
vinculin isoform meta-VCL [Homo sapiens]...
1134
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1TR2
94%
Homo sapiens
IDP91627
(
show subtarget assignments
)
8
cloned
No
BAB34984
13361025
ECs1561
hypothetical protein [Escherichia coli O...
1133
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP05206
(
show subtarget assignments
)
1
cloned
No
CD2247
126699865
cspBA
putative germination-specific protease [...
1132
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3I6S
10.5%
Clostridium difficile
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP04218
(
show subtarget assignments
)
1
expressed
No
STM2996_1_1123
16766298
recC
exonuclease V subunit gamma [Salmonella ...
1123
Salmonella essential protein
Phase 4: April 2009
1W36
88.4%
Salmonella enterica
IDP00181
(
show subtarget assignments
)
1
soluble
No
YPO0363
16120698
-
putative membrane transport protein
1119
Similar to Essential SALTY
Phase 1: October 2007
2OAU
5%
Yersinia pestis
DNA metabolism
DNA replication, recombination, and repair
IDP91038
(
show subtarget assignments
)
8
cloned
No
SAHV_2481
156980811
hypothetical protein SAHV_2481 [Staphylo...
1115
drug resistance /
SasG is a highly interesting multi-domain protein involved in biofilm formation ...
Community Requests
3TIQ
18.7%
Staphylococcus aureus
IDP92136
(
show subtarget assignments
)
8
selected
No
TGME49_112510
211962137
hypothetical protein TGME49_112510 [Toxo...
1107
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
IDP92046
(
show subtarget assignments
)
8
selected
No
TGME49_007640
211967232
isoleucine-tRNA synthetase, putative [To...
1103
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1ILE
30.6%
Toxoplasma gondii
IDP04415
(
show subtarget assignments
)
8
selected
No
CAC05837
12329106
icsA (virG)
IcsA (VirG), outermembrane protein expos...
1102
Shigella effector protein
Community Requests
3ML3
15.2%
Shigella flexneri
IDP05250
(
show subtarget assignments
)
1
soluble
No
lmo2446
16804484
-
hypothetical protein lmo2446 [Listeria m...
1091
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2X2H
19%
Listeria monocytogenes
Central intermediary metabolism: Other
IDP90807
(
show subtarget assignments
)
8
cloned
No
Cj0279
15791649
carB
carbamoyl phosphate synthase large subun...
1089
Predicted Essential
Community Requests
1BXR
55.3%
Campylobacter jejuni
IDP91542
(
show subtarget assignments
)
8
selected
No
TGME49_080410
237844275
3',5'-cyclic phosphodiesterase, putative...
1085
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
1SO2
11.2%
Toxoplasma gondii
IDP90254
(
show subtarget assignments
)
8
selected
No
AAK67494
21263110
ie1
IE1 protein [Human herpesvirus 6]
1078
(From requester) The IE1 protein of HHV-6, one of the first viral proteins synth...
Community Requests
Human herpesvirus
IDP90592
(
show subtarget assignments
)
8
in_crystallization_trials
No
VC2389
15642386
carB
carbamoyl phosphate synthase large subun...
1076
Predicted Essential
Community Requests
1BXR
85.6%
Vibrio cholerae
IDP04425
(
show subtarget assignments
)
1
cloned
No
GBAA4025
47529318
carB
carbamoyl phosphate synthase large subun...
1072
conserved gene; putative drug target function;
Phase 4: April 2009
1BXR
49.3%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides
Pyrimidine ribonucleotide biosynthesis
IDP00005
(
show subtarget assignments
)
1
cloned
No
BA_0552
30254078
internalin, putative
1070
Virulence/Drug Target Homolog
Phase 1: October 2007
1M9S
13.5%
Bacillus anthracis
Cellular processes
Pathogenesis
IDP00671
(
show subtarget assignments
)
1
purified
No
SACOL1215
57285958
carB
carbamoyl phosphate synthase large subun...
1057
Drug Target Function
Phase 2: March 2008
1BXR
49.6%
Staphylococcus aureus
Purines, pyrimidines, nucleosides, and nucleotides
Pyrimidine ribonucleotide biosynthesis
IDP92132
(
show subtarget assignments
)
8
selected
No
TGME49_053290
237840177
valyl-tRNA synthetase, putative [Toxopla...
1042
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1GAX
35.3%
Toxoplasma gondii
IDP92552
(
show subtarget assignments
)
8
selected
No
NP_071445
11545912
NOD2
nucleotide-binding oligomerization domai...
1040
innate immunity /
JUSTIFICATION:NOD2 is a cytoplasmic protein containing 1040 residus and three fu...
Community Requests
1DFJ
9%
Homo sapiens
IDP91949
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007099
298255351
pneumococcal histidine triad protein E [...
1039
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2CS7
4.2%
Streptococcus pneumoniae
IDP04529
(
show subtarget assignments
)
1
crystallized
No
STM2481_1_1037
16765801
acrD
aminoglycoside/multidrug efflux system [...
1037
Salmonella essential protein
Phase 4: April 2009
1IWG
66.2%
Salmonella enterica
IDP92131
(
show subtarget assignments
)
8
selected
No
TGME49_019540
237842821
alanyl-tRNA synthetase, putative [Toxopl...
1037
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2ZZF
21.2%
Toxoplasma gondii
IDP91749
(
show subtarget assignments
)
8
selected
No
Q9DUM3_HHV8
0
1036
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3H0G
9.3%
Human herpesvirus
IDP90434
(
show subtarget assignments
)
8
cloned
No
CT_870
3329345
pmpF
Putative Outer Membrane Protein F [Chlam...
1034
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP05142
(
show subtarget assignments
)
1
cloned
No
BAS2027
49185038
-
isoleucyl-tRNA synthetase [Bacillus anth...
1033
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1ILE
38.4%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP01952
(
show subtarget assignments
)
1
cloned
No
Cj1432c
15792750
putative sugar transferase [Campylobacte...
1031
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
2IV7
7.7%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04186
(
show subtarget assignments
)
1
cloned
No
VCA0709
9658128
sensor protein TorS [Vibrio cholerae O1 ...
1020
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3I9Y
17.1%
Vibrio cholerae
Regulatory functions
Other
IDP01784
(
show subtarget assignments
)
1
expressed
No
STM1383
16764733
ttrA
tetrathionate reductase complex subunit ...
1020
Conserved; Drug target functions
Phase 3: June 2008
2IVF
18.1%
Salmonella enterica
Energy metabolism
Electron transport
IDP00843
(
show subtarget assignments
)
1
cloned
No
SACOL1859
57284780
hypothetical protein SACOL1859
1016
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
0
0
IDP90436
(
show subtarget assignments
)
8
cloned
No
CT_872
3329347
pmpH
Putative Outer Membrane Protein H [Chlam...
1016
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP05502
(
show subtarget assignments
)
1
cloned
No
CD0386
126697956
putative collagen-binding surface protei...
1014
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Unknown function: General
IDP05538
(
show subtarget assignments
)
1
cloned
No
CD3392
126701015
putative collagen-binding surface protei...
1014
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Unknown function: General
IDP90435
(
show subtarget assignments
)
8
cloned
No
CT_871
3329346
pmpG
Putative Outer Membrane Protein G [Chlam...
1013
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00513
(
show subtarget assignments
)
1
cloned
No
YPO3674
16123817
putative insecticidal toxin
1011
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP92130
(
show subtarget assignments
)
8
selected
No
TGME49_061800
237832029
helicase, putative [Toxoplasma gondii ME...
1008
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
IDP90350
(
show subtarget assignments
)
8
cloned
No
CT456
15605183
hypothetical protein CT456 [Chlamydia tr...
1005
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91638
(
show subtarget assignments
)
8
expressed
No
NP_216897
15609518
polyketide synthetase MBTD (polyketide s...
1004
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
2HG4
15.5%
Mycobacterium tuberculosis
IDP92010
(
show subtarget assignments
)
8
selected
No
TGME49_069660
237832699
TFIIH basal transcription factor complex...
997
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2FWR
12.2%
Toxoplasma gondii
IDP92066
(
show subtarget assignments
)
8
selected
No
ABO93620
144228223
GAPDH2
apicoplast glyceraldehyde-3-phosphate de...
995
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3STH
20.3%
Toxoplasma gondii
IDP05106
(
show subtarget assignments
)
1
cloned
No
CD1469
126699073
cell surface protein (putative penicilli...
990
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2QMI
10%
Clostridium difficile
Cell envelope: Other
IDP92129
(
show subtarget assignments
)
8
selected
No
TGME49_007990
237840609
ftsJ-like methyltransferase domain-conta...
981
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1EIZ
6.9%
Toxoplasma gondii
IDP90383
(
show subtarget assignments
)
8
cloned
No
CT_412
3328840
pmpA
Putative outer membrane protein A [Chlam...
975
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91911
(
show subtarget assignments
)
8
selected
No
SpneCM_010100005012
298254959
G5 domain family protein, partial [Strep...
974
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3HQV
21.7%
Streptococcus pneumoniae
IDP05117
(
show subtarget assignments
)
1
cloned
No
CD2831
126700447
putative collagen-binding protein [Clost...
972
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
9.3%
Clostridium difficile
Unknown function: General
IDP05412
(
show subtarget assignments
)
1
soluble
No
BA_3584
30258112
putative microbial collagenase [Bacillus...
971
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2Y3U
38.9%
Bacillus anthracis
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP92128
(
show subtarget assignments
)
8
selected
No
TGME49_082200
237844257
clpB protein, putative [Toxoplasma gondi...
970
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1QVR
38.7%
Toxoplasma gondii
IDP05088
(
show subtarget assignments
)
1
cloned
No
BA_0871
30254621
LPXTG-motif cell wall anchor domain prot...
969
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
10.8%
Bacillus anthracis
Cell envelope: Other
IDP92127
(
show subtarget assignments
)
8
selected
No
TGME49_021310
237841325
aminopeptidase N, putative [Toxoplasma g...
966
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2GTQ
33.6%
Toxoplasma gondii
IDP90598
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3443
16123591
valS
valyl-tRNA synthetase [Yersinia pestis C...
965
Predicted Essential
Community Requests
1GAX
40.5%
Yersinia pestis
IDP02298
(
show subtarget assignments
)
1
soluble
No
GBAA0555
47525828
collagenase,putative [Bacillus anthracis...
965
Drug target motif; Involved in sporulation; Drug target functions
Phase 3: June 2008
2Y3U
39.2%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP90437
(
show subtarget assignments
)
8
cloned
No
CT_869
3329344
pmpE
Putative Outer Membrane Protein E [Chlam...
964
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00423
(
show subtarget assignments
)
1
soluble
No
YPO1019
16121320
ptrA
protease III precursor
962
Drug Target Function
Phase 2: March 2008
1Q2L
61.5%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02563
(
show subtarget assignments
)
1
cloned
No
GBAA3299
47528584
collagenase, putative [Bacillus anthraci...
960
Drug target motif; Vaccine Target; Drug target functions
Phase 3: June 2008
2Y3U
39.2%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP04450
(
show subtarget assignments
)
1
cloned
No
YPO0905
218928078
gcvP
glycine dehydrogenase [Yersinia pestis C...
959
conserved gene; putative drug target function;
Phase 4: April 2009
1WYT
19.1%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP91755
(
show subtarget assignments
)
8
selected
No
TXD11_HUMAN
0
958
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2B5E
7%
Homo sapiens
IDP90327
(
show subtarget assignments
)
8
cloned
No
CT_590
3329033
hypothetical protein [Chlamydia trachoma...
954
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90658
(
show subtarget assignments
)
8
cloned
No
VC2503
15642499
valS
valyl-tRNA synthetase [Vibrio cholerae O...
953
Predicted Essential
Community Requests
1GAX
38.8%
Vibrio cholerae
IDP01384
(
show subtarget assignments
)
1
purified
No
VC0554
15640576
protease, insulinase family/protease, in...
952
Drug Target Function
Phase 2: March 2008
1Q2L
19.4%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP04446
(
show subtarget assignments
)
1
cloned
No
YPO0653
115346457
glnE
glutamate-ammonia-ligase adenylyltransfe...
951
conserved gene; putative drug target function;
Phase 4: April 2009
3K7D
38.5%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP05568
(
show subtarget assignments
)
1
cloned
No
S4492
30043719
valS
valine tRNA synthetase [Shigella flexner...
951
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1GAX
39.9%
Shigella flexneri
Protein synthesis: tRNA aminoacylation
IDP91721
(
show subtarget assignments
)
8
selected
No
NP_079032
221316695
MMRN2
multimerin-2 precursor [Homo sapiens]
949
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Homo sapiens
IDP90823
(
show subtarget assignments
)
8
soluble
No
VC0682
15640701
ileS
isoleucyl-tRNA synthetase [Vibrio choler...
949
Predicted Essential
Community Requests
1FFY
43.1%
Vibrio cholerae
IDP01050
(
show subtarget assignments
)
1
cloned
No
STM3201
16766501
glnE
bifunctional glutamine-synthetase adenyl...
947
Conserved Gene / Pathway
Phase 2: March 2008
3K7D
47.3%
Salmonella enterica
Protein synthesis
Translation factors
IDP90764
(
show subtarget assignments
)
8
purified
No
STM0046
16763436
ileS
isoleucyl-tRNA synthetase [Salmonella ty...
944
Predicted Essential
Community Requests
1FFY
42.2%
Salmonella enterica
IDP04395
(
show subtarget assignments
)
1
cloned
No
FTT0076
56707255
sucA
2-oxoglutarate dehydrogenase E1 componen...
941
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2JGD
47.8%
Francisella tularensis
IDP05699
(
show subtarget assignments
)
1
cloned
No
lmo2396
16804434
-
hypothetical protein lmo2396 [Listeria m...
940
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1O6S
10.9%
Listeria monocytogenes
Transport and binding proteins: Amino acids, peptides and amines
IDP02255
(
show subtarget assignments
)
1
cloned
No
FTT1130c
56708207
cphA
cyanophycin synthetase [Francisella tula...
940
Drug Target
Phase 3: June 2008
2WTZ
13.3%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
OtherNitrogen metabolism
IDP02181
(
show subtarget assignments
)
1
cloned
No
YPO0256
16120593
two-component sensor/regulator [Yersinia...
939
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
2C2A
8%
Yersinia pestis
Regulatory functions
Other
IDP92012
(
show subtarget assignments
)
8
selected
No
TGME49_037830
237845437
DNA polymerase I, putative [Toxoplasma g...
938
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2BDP
17.4%
Toxoplasma gondii
IDP90911
(
show subtarget assignments
)
8
soluble
No
YPO0475
16120804
ileS
isoleucyl-tRNA synthetase [Yersinia pest...
938
Predicted Essential
Community Requests
1FFY
43.2%
Yersinia pestis
IDP02744
(
show subtarget assignments
)
1
cloned
No
FTT0087
56707265
acnA
aconitate hydratase [Francisella tularen...
937
Drug Target
Phase 3: June 2008
3SN2
50.5%
Francisella tularensis
Energy metabolism
TCA cycle
IDP92017
(
show subtarget assignments
)
8
selected
No
ADC80544
289064337
glutamine aminoacyl-tRNA synthetase [Tox...
937
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1EUQ
31.2%
Toxoplasma gondii
IDP00567
(
show subtarget assignments
)
0
work_stopped
No
YPO1113
16121413
kgd
alpha-ketoglutarate decarboxylase
935
Virulence Associated Factor
Phase 2: March 2008
2JGD
87.8%
Yersinia pestis
Energy metabolism
TCA cycle
IDP04484
(
show subtarget assignments
)
1
purified
No
YPO3381
115349009
barA
two-component regulatory protein [Yersin...
930
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
7.8%
Yersinia pestis
Regulatory functions
Other
IDP92126
(
show subtarget assignments
)
8
selected
No
TGME49_068650
237832521
clp ATP-binding chain B1, putative [Toxo...
929
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1QVR
48.9%
Toxoplasma gondii
IDP04543
(
show subtarget assignments
)
1
expressed
No
VC2453
9657030
sensor histidine kinase/response regulat...
927
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
8.1%
Vibrio cholerae
Regulatory functions
Other
IDP01428
(
show subtarget assignments
)
1
purified
No
VC1709
15641713
zinc protease, insulinase family
922
Drug Target Function
Phase 2: March 2008
3CWW
19%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP92125
(
show subtarget assignments
)
8
selected
No
TGME49_057990
237831451
heat shock protein, putative [Toxoplasma...
921
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1QVR
46.4%
Toxoplasma gondii
IDP05693
(
show subtarget assignments
)
1
soluble
No
lmo2019
16804058
ileS
isoleucyl-tRNA synthetase [Listeria mono...
921
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1FFY
61.4%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP04121
(
show subtarget assignments
)
1
cloned
No
YPO2725
115348408
conserved hypothetical protein [Yersinia...
921
virulence factor; putative drug target function;
Phase 4: April 2009
2P5Z
12.6%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP04368
(
show subtarget assignments
)
1
selected
No
BAS3746
49186745
isoleucyl-tRNA synthetase [Bacillus anth...
921
Proposed to be essential proteins
Phase 4: April 2009
1FFY
63.3%
Bacillus anthracis
IDP01908
(
show subtarget assignments
)
1
cloned
No
STM1392
16764742
ssrA
sensor kinase [Salmonella typhimurium LT...
920
Conserved; Drug target functions
Phase 3: June 2008
2C2A
7.1%
Salmonella enterica
Energy metabolism
Anaerobic
IDP91352
(
show subtarget assignments
)
8
cloned
No
VV1_3095
27366363
electron transport complex protein RnfC ...
919
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP01859
(
show subtarget assignments
)
1
cloned
No
lmo2558
16804596
ami
autolysin, amidase [Listeria monocytogen...
917
Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838
Phase 3: June 2008
1M9S
14.7%
Listeria monocytogenes
Transport and binding proteins
Unknown substrate
IDP90761
(
show subtarget assignments
)
8
cloned
No
Cj1061c
15792388
ileS
isoleucyl-tRNA synthetase [Campylobacter...
917
Predicted Essential
Community Requests
1FFY
38.8%
Campylobacter jejuni
IDP02558
(
show subtarget assignments
)
1
cloned
No
GBAA4584
47529880
vpR
minor extracellular protease VpR [Bacill...
917
Drug target motif; Drug target functions
Phase 3: June 2008
3EIF
22.4%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP92013
(
show subtarget assignments
)
8
selected
No
TGME49_034280
237839141
adenosine monophosphate deaminase, putat...
914
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2A3L
30.4%
Toxoplasma gondii
IDP02061
(
show subtarget assignments
)
1
cloned
No
CBU_0147
29540767
secA
preprotein translocase, SecA subunit [Co...
913
Conserved; Drug target functions
Phase 3: June 2008
2FSF
59.9%
Coxiella burnetii
Protein fate
Protein and peptide secretion and trafficking
IDP92014
(
show subtarget assignments
)
8
selected
No
TGME49_067100
237838983
protein phosphatase 2C, putative [Toxopl...
909
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2I0O
10.2%
Toxoplasma gondii
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