Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02615 (show subtarget assignments)	1	expressed	No	GBAA4677	47529976		ribonuclease [Bacillus anthracis str. 'A...	458	Conserved; Drug target functions	Phase 3: June 2008	2BX2	27.7%	Bacillus anthracis	Cellular processes	Cell division

IDP04305 (show subtarget assignments)	1	cloned	No	CPF_2386	110798631		ribonuclease [Clostridium perfringens AT...	480	conserved gene; putative drug target function;	Phase 4: April 2009	2BX2	27.7%	Clostridium perfringens	Cellular processes	Cell division

IDP01879 (show subtarget assignments)	1	cloned	No	FTT1804c	56708790	rng	ribonuclease G [Francisella tularensis s...	498	Conserved; Drug target functions	Phase 3: June 2008	2BX2	31.9%	Francisella tularensis	Cellular processesTranscription	Cell divisionRNA processing

IDP90533 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0996	15792323	ribA	GTP cyclohydrolase II [Campylobacter jej...	186	Predicted Essential	Community Requests	2BZ0	47.2%	Campylobacter jejuni

IDP91231 (show subtarget assignments)	8	soluble	No	NT04EC1793	26108012	ribA	GTP cyclohydrolase II [Escherichia coli ...	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	99.5%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91241 (show subtarget assignments)	8	soluble	No	HP0802	2313933		GTP cyclohydrolase II (ribA) [Helicobact...	192	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	47.7%	Helicobacter pylori	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91299 (show subtarget assignments)	8	cloned	No	STM1711	16765055	ribA	GTP cyclohydrolase II protein	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	95.4%	Salmonella enterica

IDP91289 (show subtarget assignments)	8	soluble	No	SPA1165	56413363	ribA	GTP cyclohydrolase II [Salmonella enteri...	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	95.4%	Salmonella enterica

IDP00400 (show subtarget assignments)	0	work_stopped	No	YPO2222	16122451	ribA	GTP cyclohydrolase II	196	Virulence Associated Factor	Phase 2: March 2008	2BZ0	88.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00313 (show subtarget assignments)	1	expressed	No	CBU_0647	29653985	ribA	riboflavin biosynthesis protein RibA	406	Drug Target Function	Phase 2: March 2008	2BZ0	27.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00017 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4333	81581445	ribBA	Riboflavin biosynthesis protein ribBA [I...	397	Drug Target Homolog	Phase 1: October 2007	2BZ0	27%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91726 (show subtarget assignments)	8	selected	No	NP_116784	14670388	BAD	bcl2 antagonist of cell death [Homo sapi...	168	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2BZW	14.9%	Homo sapiens

IDP92028 (show subtarget assignments)	8	selected	No	TGME49_017740	237844087		oxoacyl-ACP reductase, putative [Toxopla...	376	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C07	35.9%	Toxoplasma gondii

IDP91697 (show subtarget assignments)	8	selected	No	NP_002341	4505055	LYN	tyrosine-protein kinase Lyn isoform A [H...	512	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2C0I	66.6%	Homo sapiens

IDP05628 (show subtarget assignments)	1	soluble	No	CD1444	126699048		putative exported polysaccharide deacety...	239	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	32.6%	Clostridium difficile	Unknown function: General

IDP05199 (show subtarget assignments)	1	soluble	No	CD1556	126699160		putative polysaccharide deacetylase [Clo...	277	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	22.7%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05225 (show subtarget assignments)	1	cloned	No	lmo0415	16802459	-	hypothetical protein lmo0415 [Listeria m...	466	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	29%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05613 (show subtarget assignments)	1	expressed	No	BA_5436	30259904		putative polysaccharide deacetylase [Bac...	245	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	29%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05408 (show subtarget assignments)	1	soluble	No	BA_1977	30256632		putative polysaccharide deacetylase [Bac...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	31.1%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02579 (show subtarget assignments)	1	cloned	No	Cj1131c	15792456	galE	UDP-glucose 4-epimerase [Campylobacter j...	328	Predicted virulence-Posttranslational modification	Phase 3: June 2008	2C20	41.5%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP02181 (show subtarget assignments)	1	cloned	No	YPO0256	16120593		two-component sensor/regulator [Yersinia...	939	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008	2C2A	8%	Yersinia pestis	Regulatory functions	Other

IDP04662 (show subtarget assignments)	1	cloned	No	GBAA0650	47525929		sensor histidine kinase [Bacillus anthra...	463	putative drug target function;	Phase 4: April 2009	2C2A	17.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04430 (show subtarget assignments)	1	purified	No	GBAA4921	47530215		sensor histidine kinase [Bacillus anthra...	484	putative drug target function;	Phase 4: April 2009	2C2A	16.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04189 (show subtarget assignments)	1	expressed	No	CPF_0225	110799110		sensor histidine kinase [Clostridium per...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04664 (show subtarget assignments)	1	purified	No	GBAA0996	47526275		sensor histidine kinase/response regulat...	896	putative drug target function;	Phase 4: April 2009	2C2A	10.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04164 (show subtarget assignments)	1	cloned	No	VC1445	15641456		sensor histidine kinase/response regulat...	572	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.5%	Vibrio cholerae	Regulatory functions	Other

IDP04692 (show subtarget assignments)	1	expressed	No	GBAA5105	47778363		sensor histidine kinase [Bacillus anthra...	368	putative drug target function;	Phase 4: April 2009	2C2A	20.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04076 (show subtarget assignments)	1	expressed	No	GBAA2213	47527506		sensor histidine kinase [Bacillus anthra...	452	putative drug target function;	Phase 4: April 2009	2C2A	18.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04431 (show subtarget assignments)	1	cloned	No	GBAA5088	47530387		sensor histidine kinase [Bacillus anthra...	340	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	18.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04272 (show subtarget assignments)	1	expressed	No	GBAA3899	47529188		lantibiotic biosynthesis sensor histidin...	453	putative drug target function;	Phase 4: April 2009	2C2A	14.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02415 (show subtarget assignments)	1	soluble	No	CBU_1761	29542318		sensory box sensor histidine kinase/resp...	657	Conserved; Drug target functions	Phase 3: June 2008	2C2A	11.6%	Coxiella burnetii	Signal transduction	Two-component systems

IDP04484 (show subtarget assignments)	1	purified	No	YPO3381	115349009	barA	two-component regulatory protein [Yersin...	930	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	7.8%	Yersinia pestis	Regulatory functions	Other

IDP04556 (show subtarget assignments)	1	cloned	No	YPO3008	218930055		putative two-component sensor histidine ...	514	putative drug target function;	Phase 4: April 2009	2C2A	16%	Yersinia pestis	Regulatory functions	Other

IDP04184 (show subtarget assignments)	1	expressed	No	VCA0522	15601282		sensor histidine kinase/response regulat...	686	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.9%	Vibrio cholerae	Regulatory functions	Other

IDP01908 (show subtarget assignments)	1	cloned	No	STM1392	16764742	ssrA	sensor kinase [Salmonella typhimurium LT...	920	Conserved; Drug target functions	Phase 3: June 2008	2C2A	7.1%	Salmonella enterica	Energy metabolism	Anaerobic

IDP04515 (show subtarget assignments)	1	expressed	No	CPF_2673	110799735		putative sensor histidine kinase [Clostr...	583	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04665 (show subtarget assignments)	1	purified	No	GBAA1118	47526389		sensor histidine kinase [Bacillus anthra...	580	putative drug target function;	Phase 4: April 2009	2C2A	11.4%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04007 (show subtarget assignments)	1	expressed	No	VC1319	15641331		sensor histidine kinase [Vibrio cholerae...	440	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Vibrio cholerae	Regulatory functions	Other

IDP04505 (show subtarget assignments)	1	soluble	No	VCA0531	15601291		sensor histidine kinase [Vibrio cholerae...	497	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.9%	Vibrio cholerae	Regulatory functions	Other

IDP04104 (show subtarget assignments)	1	expressed	No	YPO2309	115348012	rstB	two-component regulatory system, sensor ...	425	putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Yersinia pestis	Regulatory functions	Other

IDP04133 (show subtarget assignments)	1	cloned	No	CPF_1195	110798868	hpkA	sensor histidine kinase [Clostridium per...	287	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	25.8%	Clostridium perfringens	Regulatory functions	Other

IDP01805 (show subtarget assignments)	1	soluble	No	CBU_1084	29541658		sensory box sensor histidine kinase/resp...	683	Conserved; Drug target functions	Phase 3: June 2008	2C2A	12.4%	Coxiella burnetii	Signal transduction	Two-component systems

IDP04428 (show subtarget assignments)	1	soluble	No	GBAA4832	47530128	phoR	sensory box histidine kinase PhoR [Bacil...	587	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01779 (show subtarget assignments)	1	soluble	No	CBU_0366	29540977	phoR	sensor histidine kinase PhoR protein, pu...	252	Conserved; Drug target functions	Phase 3: June 2008	2C2A	31.3%	Coxiella burnetii	Signal transduction	Two-component systems

IDP04227 (show subtarget assignments)	1	expressed	No	CPF_0198	110799765		sensory box histidine kinase [Clostridiu...	791	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.6%	Clostridium perfringens	Regulatory functions

IDP04438 (show subtarget assignments)	1	expressed	No	YPO0073	115345903	cpxA	two component sensor kinase [Yersinia pe...	458	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.8%	Yersinia pestis	Regulatory functions	Other

IDP04182 (show subtarget assignments)	1	cloned	No	VCA0238	15601006		sensor histidine kinase [Vibrio cholerae...	549	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	12%	Vibrio cholerae	Regulatory functions	Other

IDP04543 (show subtarget assignments)	1	expressed	No	VC2453	9657030		sensor histidine kinase/response regulat...	927	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	8.1%	Vibrio cholerae	Regulatory functions	Other

IDP01736 (show subtarget assignments)	1	expressed	No	GBAA5503	47530821		sensor histidine kinase [Bacillus anthra...	476	Conserved; Drug target functions	Phase 3: June 2008	2C2A	15.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04397 (show subtarget assignments)	1	expressed	No	GBAA3230	47528520		sensor histidine kinase [Bacillus anthra...	457	putative drug target function;	Phase 4: April 2009	2C2A	17.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04163 (show subtarget assignments)	1	expressed	No	VC1349	15641361		sensory box sensor histidine kinase/resp...	1331	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	6.5%	Vibrio cholerae	Regulatory functions	Other

IDP04358 (show subtarget assignments)	1	cloned	No	YPO0895	115346679	creC	putative histidine kinase sensor [Yersin...	472	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.8%	Yersinia pestis	Regulatory functions	Other

IDP04569 (show subtarget assignments)	1	cloned	No	CPF_2242	110799545		sensor histidine kinase [Clostridium per...	620	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04302 (show subtarget assignments)	1	soluble	No	CPF_2503	110801437		sensor histidine kinase [Clostridium per...	471	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.6%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04352 (show subtarget assignments)	1	soluble	No	GBAA0584	47525859		sensor histidine kinase [Bacillus anthra...	487	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04733 (show subtarget assignments)	1	cloned	No	CBU_0789	215919045		two component system histidine kinase [C...	831	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.5%	Coxiella burnetii	Signal transduction	Two-component systems

IDP04659 (show subtarget assignments)	1	soluble	No	GBAA0272	47525531		sensor histidine kinase [Bacillus anthra...	501	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04632 (show subtarget assignments)	1	cloned	No	CBU_2005	29655288	rstB	signal transduction histidine kinase-lik...	425	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.2%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP04419 (show subtarget assignments)	1	soluble	No	GBAA2861	47528156		sensor histidine kinase SrrB, putative [...	458	putative drug target function;	Phase 4: April 2009	2C2A	18.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04661 (show subtarget assignments)	1	expressed	No	GBAA0572	47777831		sensor histidine kinase [Bacillus anthra...	416	putative drug target function;	Phase 4: April 2009	2C2A	16.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04667 (show subtarget assignments)	1	cloned	No	GBAA1313	47526578		sensor histidine kinase [Bacillus anthra...	466	putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04243 (show subtarget assignments)	1	soluble	No	CPF_1140	110799522		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04304 (show subtarget assignments)	1	cloned	No	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04401 (show subtarget assignments)	1	expressed	No	VC1831	15641833		sensor histidine kinase [Vibrio cholerae...	736	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.2%	Vibrio cholerae	Regulatory functions	Other

IDP92003 (show subtarget assignments)	8	selected	No	SpneCM_010100002775	298254522		sensor histidine kinase [Streptococcus p...	350	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2C2A	22%	Streptococcus pneumoniae

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP04382 (show subtarget assignments)	1	expressed	No	CPF_0116	110801065		sensor histidine kinase [Clostridium per...	337	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17.8%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04660 (show subtarget assignments)	1	expressed	No	GBAA0286	47777799		sensor histidine kinase, putative [Bacil...	314	putative drug target function;	Phase 4: April 2009	2C2A	24.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04371 (show subtarget assignments)	1	expressed	No	GBAA4776	47778322		sensor histidine kinase [Bacillus anthra...	311	putative drug target function;	Phase 4: April 2009	2C2A	19.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04342 (show subtarget assignments)	1	cloned	No	GBAA1564	47526837	panD	aspartate alpha-decarboxylase [Bacillus ...	127	conserved gene; putative drug target function;	Phase 4: April 2009	2C45	52.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04253 (show subtarget assignments)	1	purified	No	CPF_1800	110800480	prs	phosphoribosylpyrophosphate synthetase [...	364	conserved gene; putative drug target function;	Phase 4: April 2009	2C4K	25.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04473 (show subtarget assignments)	1	expressed	No	YPO2624	115348316	nagD	putative N-acetylglucosamine metabolism ...	250	conserved gene; putative drug target function;	Phase 4: April 2009	2C4N	86%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP91207 (show subtarget assignments)	8	soluble	No	BT_2842	29348251		3-dehydroquinate dehydratase [Bacteroide...	140	potential drug target / Shikimate pathway enzyme	Community Requests	2C4W	49%	Bacteroides thetaiotaomicron

IDP05099 (show subtarget assignments)	1	cloned	No	CD0754	126698334	thiI	thiamine biosynthesis protein ThiI [Clos...	391	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2C5S	42.2%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP04014 (show subtarget assignments)	1	purified	No	YPO3173	115348814	thiI	thiamine biosynthesis protein [Yersinia ...	483	conserved gene; putative drug target function;	Phase 4: April 2009	2C5S	23.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP92032 (show subtarget assignments)	8	selected	No	TGME49_019800	237842869		vacuolar ATP synthase subunit B, putativ...	505	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C61	53.9%	Toxoplasma gondii

IDP05037 (show subtarget assignments)	1	soluble	No	BA_1836	30256106		putative polysaccharide deacetylase [Bac...	234	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C71	27.4%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01724 (show subtarget assignments)	1	expressed	No	GBAA5248	47530553		acetyl-CoA acetyltransferase [Bacillus a...	390	Conserved; Essential; Drug target functions	Phase 3: June 2008	2C7Y	47.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP04666 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1158	47526425	hemH-2	ferrochelatase [Bacillus anthracis str. ...	319	putative drug target function;	Phase 4: April 2009	2C8J	62.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP92077 (show subtarget assignments)	8	selected	No	TGME49_097370	237843739		ruvB-like 1, putative [Toxoplasma gondii...	463	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C9O	62.9%	Toxoplasma gondii

IDP92030 (show subtarget assignments)	8	selected	No	TGME49_019590	237842827		ruvB-like 1, putative [Toxoplasma gondii...	492	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C9O	55.9%	Toxoplasma gondii

IDP02184 (show subtarget assignments)	1	expressed	No	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP90858 (show subtarget assignments)	8	in_crystallization_trials	No	O31153	30179879		Glutamyl-tRNA synthetase (Glutamate--tRN...	474	Predicted Essential	Community Requests	2CFO	40.2%	Vibrio cholerae

IDP90921 (show subtarget assignments)	8	purified	No	YPO2984	16123165	gltX	glutamyl-tRNA synthetase [Yersinia pesti...	471	Predicted Essential	Community Requests	2CFO	38.4%	Yersinia pestis

IDP90662 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1288c	15792611	gltX	glutamyl-tRNA synthetase [Campylobacter ...	463	Predicted Essential	Community Requests	2CFO	38.9%	Campylobacter jejuni

IDP91972 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100003825	298254730		iron-compound ABC transporter, iron-comp...	321	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2CHU	37.4%	Streptococcus pneumoniae

IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP91932 (show subtarget assignments)	8	selected	No	SpneCM_010100007089	298255349		pneumococcal histidine triad protein E [...	189	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2CS7	12.7%	Streptococcus pneumoniae

IDP91924 (show subtarget assignments)	8	selected	No	SpneCM_010100007441	298255419		pneumococcal histidine triad protein B [...	574	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2CS7	5.1%	Streptococcus pneumoniae

IDP91949 (show subtarget assignments)	8	selected	No	SpneCM_010100007099	298255351		pneumococcal histidine triad protein E [...	1039	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2CS7	4.2%	Streptococcus pneumoniae

IDP91818 (show subtarget assignments)	8	cloned	No	b2584	1788938	yfiQ	inhibiting acetyltransferase for acetyl-...	886	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	2CSU	17.3%	Escherichia coli

IDP05574 (show subtarget assignments)	1	soluble	No	SACOL0533	57651372	metS	methionyl-tRNA synthetase [Staphylococcu...	657	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2CSX	35.3%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05320 (show subtarget assignments)	1	cloned	No	lmo0177	16802223	metS	methionyl-tRNA synthetase [Listeria mono...	630	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2CSX	35.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90787 (show subtarget assignments)	8	purified	No	Cj0838c	15792176	metG	methionyl-tRNA synthetase [Campylobacter...	628	Predicted Essential	Community Requests	2CSX	38.5%	Campylobacter jejuni

IDP90854 (show subtarget assignments)	8	crystallized	No	Cj1727c	15793030	metY	putative O-acetylhomoserine (thiol)-lyas...	423	Predicted Essential	Community Requests	2CTZ	40.9%	Campylobacter jejuni

IDP04290 (show subtarget assignments)	1	cloned	No	YPO3099	218930141	manC	mannose-1-phosphate guanylyltransferase ...	470	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2CU2	28.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides

IDP01054 (show subtarget assignments)	1	purified	No	STM3363	16766658	yhcO	putative cytoplasmic protein	90	Conserved Gene / Pathway	Phase 2: March 2008	2CX6	76.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP90352 (show subtarget assignments)	8	expressed	No	CT262	15604983		hypothetical protein CT262 [Chlamydia tr...	256	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2CZL	32%	Chlamydia trachomatis

IDP91003 (show subtarget assignments)	8	soluble	No	y1934	22125826	sufA	iron-sulfur cluster assembly scaffold pr...	132	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	2D2A	59.8%	Yersinia pestis

IDP02615
(show subtarget assignments)

1

expressed

No

GBAA4677

47529976

ribonuclease [Bacillus anthracis str. 'A...

458

Conserved; Drug target functions

Phase 3: June 2008

2BX2

27.7%

Bacillus anthracis

Cellular processes

Cell division

IDP04305
(show subtarget assignments)

1

cloned

No

CPF_2386

110798631

ribonuclease [Clostridium perfringens AT...

480

conserved gene; putative drug target function;

Phase 4: April 2009

2BX2

27.7%

Clostridium perfringens

Cellular processes

Cell division

IDP01879
(show subtarget assignments)

1

cloned

No

FTT1804c

56708790

rng

ribonuclease G [Francisella tularensis s...

498

Conserved; Drug target functions

Phase 3: June 2008

2BX2

31.9%

Francisella tularensis

Cellular processesTranscription

Cell divisionRNA processing

IDP90533
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0996

15792323

ribA

GTP cyclohydrolase II [Campylobacter jej...

186

Predicted Essential

Community Requests

2BZ0

47.2%

Campylobacter jejuni

IDP91231
(show subtarget assignments)

8

soluble

No

NT04EC1793

26108012

ribA

GTP cyclohydrolase II [Escherichia coli ...

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

99.5%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91241
(show subtarget assignments)

8

soluble

No

HP0802

2313933

GTP cyclohydrolase II (ribA) [Helicobact...

192

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

47.7%

Helicobacter pylori

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91299
(show subtarget assignments)

8

cloned

No

STM1711

16765055

ribA

GTP cyclohydrolase II protein

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

95.4%

Salmonella enterica

IDP91289
(show subtarget assignments)

8

soluble

No

SPA1165

56413363

ribA

GTP cyclohydrolase II [Salmonella enteri...

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

95.4%

Salmonella enterica

IDP00400
(show subtarget assignments)

0

work_stopped

No

YPO2222

16122451

ribA

GTP cyclohydrolase II

196

Virulence Associated Factor

Phase 2: March 2008

2BZ0

88.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00313
(show subtarget assignments)

1

expressed

No

CBU_0647

29653985

ribA

riboflavin biosynthesis protein RibA

406

Drug Target Function

Phase 2: March 2008

2BZ0

27.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00017
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4333

81581445

ribBA

Riboflavin biosynthesis protein ribBA [I...

397

Drug Target Homolog

Phase 1: October 2007

2BZ0

27%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91726
(show subtarget assignments)

8

selected

No

NP_116784

14670388

BAD

bcl2 antagonist of cell death [Homo sapi...

168

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2BZW

14.9%

Homo sapiens

IDP92028
(show subtarget assignments)

8

selected

No

TGME49_017740

237844087

oxoacyl-ACP reductase, putative [Toxopla...

376

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C07

35.9%

Toxoplasma gondii

IDP91697
(show subtarget assignments)

8

selected

No

NP_002341

4505055

LYN

tyrosine-protein kinase Lyn isoform A [H...

512

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2C0I

66.6%

Homo sapiens

IDP05628
(show subtarget assignments)

1

soluble

No

CD1444

126699048

putative exported polysaccharide deacety...

239

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

32.6%

Clostridium difficile

Unknown function: General

IDP05199
(show subtarget assignments)

1

soluble

No

CD1556

126699160

putative polysaccharide deacetylase [Clo...

277

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

22.7%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05225
(show subtarget assignments)

1

cloned

No

lmo0415

16802459

-

hypothetical protein lmo0415 [Listeria m...

466

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

29%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05613
(show subtarget assignments)

1

expressed

No

BA_5436

30259904

putative polysaccharide deacetylase [Bac...

245

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

29%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05408
(show subtarget assignments)

1

soluble

No

BA_1977

30256632

putative polysaccharide deacetylase [Bac...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

31.1%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02579
(show subtarget assignments)

1

cloned

No

Cj1131c

15792456

galE

UDP-glucose 4-epimerase [Campylobacter j...

328

Predicted virulence-Posttranslational modification

Phase 3: June 2008

2C20

41.5%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP02181
(show subtarget assignments)

1

cloned

No

YPO0256

16120593

two-component sensor/regulator [Yersinia...

939

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

2C2A

8%

Yersinia pestis

Regulatory functions

Other

IDP04662
(show subtarget assignments)

1

cloned

No

GBAA0650

47525929

sensor histidine kinase [Bacillus anthra...

463

putative drug target function;

Phase 4: April 2009

2C2A

17.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04430
(show subtarget assignments)

1

purified

No

GBAA4921

47530215

sensor histidine kinase [Bacillus anthra...

484

putative drug target function;

Phase 4: April 2009

2C2A

16.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04189
(show subtarget assignments)

1

expressed

No

CPF_0225

110799110

sensor histidine kinase [Clostridium per...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04664
(show subtarget assignments)

1

purified

No

GBAA0996

47526275

sensor histidine kinase/response regulat...

896

putative drug target function;

Phase 4: April 2009

2C2A

10.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04164
(show subtarget assignments)

1

cloned

No

VC1445

15641456

sensor histidine kinase/response regulat...

572

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.5%

Vibrio cholerae

Regulatory functions

Other

IDP04692
(show subtarget assignments)

1

expressed

No

GBAA5105

47778363

sensor histidine kinase [Bacillus anthra...

368

putative drug target function;

Phase 4: April 2009

2C2A

20.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04076
(show subtarget assignments)

1

expressed

No

GBAA2213

47527506

sensor histidine kinase [Bacillus anthra...

452

putative drug target function;

Phase 4: April 2009

2C2A

18.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04431
(show subtarget assignments)

1

cloned

No

GBAA5088

47530387

sensor histidine kinase [Bacillus anthra...

340

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

18.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04272
(show subtarget assignments)

1

expressed

No

GBAA3899

47529188

lantibiotic biosynthesis sensor histidin...

453

putative drug target function;

Phase 4: April 2009

2C2A

14.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02415
(show subtarget assignments)

1

soluble

No

CBU_1761

29542318

sensory box sensor histidine kinase/resp...

657

Conserved; Drug target functions

Phase 3: June 2008

2C2A

11.6%

Coxiella burnetii

Signal transduction

Two-component systems

IDP04484
(show subtarget assignments)

1

purified

No

YPO3381

115349009

barA

two-component regulatory protein [Yersin...

930

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

7.8%

Yersinia pestis

Regulatory functions

Other

IDP04556
(show subtarget assignments)

1

cloned

No

YPO3008

218930055

putative two-component sensor histidine ...

514

putative drug target function;

Phase 4: April 2009

2C2A

16%

Yersinia pestis

Regulatory functions

Other

IDP04184
(show subtarget assignments)

1

expressed

No

VCA0522

15601282

sensor histidine kinase/response regulat...

686

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.9%

Vibrio cholerae

Regulatory functions

Other

IDP01908
(show subtarget assignments)

1

cloned

No

STM1392

16764742

ssrA

sensor kinase [Salmonella typhimurium LT...

920

Conserved; Drug target functions

Phase 3: June 2008

2C2A

7.1%

Salmonella enterica

Energy metabolism

Anaerobic

IDP04515
(show subtarget assignments)

1

expressed

No

CPF_2673

110799735

putative sensor histidine kinase [Clostr...

583

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04665
(show subtarget assignments)

1

purified

No

GBAA1118

47526389

sensor histidine kinase [Bacillus anthra...

580

putative drug target function;

Phase 4: April 2009

2C2A

11.4%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04007
(show subtarget assignments)

1

expressed

No

VC1319

15641331

sensor histidine kinase [Vibrio cholerae...

440

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Vibrio cholerae

Regulatory functions

Other

IDP04505
(show subtarget assignments)

1

soluble

No

VCA0531

15601291

sensor histidine kinase [Vibrio cholerae...

497

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.9%

Vibrio cholerae

Regulatory functions

Other

IDP04104
(show subtarget assignments)

1

expressed

No

YPO2309

115348012

rstB

two-component regulatory system, sensor ...

425

putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Yersinia pestis

Regulatory functions

Other

IDP04133
(show subtarget assignments)

1

cloned

No

CPF_1195

110798868

hpkA

sensor histidine kinase [Clostridium per...

287

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

25.8%

Clostridium perfringens

Regulatory functions

Other

IDP01805
(show subtarget assignments)

1

soluble

No

CBU_1084

29541658

sensory box sensor histidine kinase/resp...

683

Conserved; Drug target functions

Phase 3: June 2008

2C2A

12.4%

Coxiella burnetii

Signal transduction

Two-component systems

IDP04428
(show subtarget assignments)

1

soluble

No

GBAA4832

47530128

phoR

sensory box histidine kinase PhoR [Bacil...

587

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01779
(show subtarget assignments)

1

soluble

No

CBU_0366

29540977

phoR

sensor histidine kinase PhoR protein, pu...

252

Conserved; Drug target functions

Phase 3: June 2008

2C2A

31.3%

Coxiella burnetii

Signal transduction

Two-component systems

IDP04227
(show subtarget assignments)

1

expressed

No

CPF_0198

110799765

sensory box histidine kinase [Clostridiu...

791

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.6%

Clostridium perfringens

Regulatory functions

IDP04438
(show subtarget assignments)

1

expressed

No

YPO0073

115345903

cpxA

two component sensor kinase [Yersinia pe...

458

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.8%

Yersinia pestis

Regulatory functions

Other

IDP04182
(show subtarget assignments)

1

cloned

No

VCA0238

15601006

sensor histidine kinase [Vibrio cholerae...

549

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

12%

Vibrio cholerae

Regulatory functions

Other

IDP04543
(show subtarget assignments)

1

expressed

No

VC2453

9657030

sensor histidine kinase/response regulat...

927

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

8.1%

Vibrio cholerae

Regulatory functions

Other

IDP01736
(show subtarget assignments)

1

expressed

No

GBAA5503

47530821

sensor histidine kinase [Bacillus anthra...

476

Conserved; Drug target functions

Phase 3: June 2008

2C2A

15.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04397
(show subtarget assignments)

1

expressed

No

GBAA3230

47528520

sensor histidine kinase [Bacillus anthra...

457

putative drug target function;

Phase 4: April 2009

2C2A

17.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04163
(show subtarget assignments)

1

expressed

No

VC1349

15641361

sensory box sensor histidine kinase/resp...

1331

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

6.5%

Vibrio cholerae

Regulatory functions

Other

IDP04358
(show subtarget assignments)

1

cloned

No

YPO0895

115346679

creC

putative histidine kinase sensor [Yersin...

472

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.8%

Yersinia pestis

Regulatory functions

Other

IDP04569
(show subtarget assignments)

1

cloned

No

CPF_2242

110799545

sensor histidine kinase [Clostridium per...

620

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04302
(show subtarget assignments)

1

soluble

No

CPF_2503

110801437

sensor histidine kinase [Clostridium per...

471

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.6%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04352
(show subtarget assignments)

1

soluble

No

GBAA0584

47525859

sensor histidine kinase [Bacillus anthra...

487

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04733
(show subtarget assignments)

1

cloned

No

CBU_0789

215919045

two component system histidine kinase [C...

831

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.5%

Coxiella burnetii

Signal transduction

Two-component systems

IDP04659
(show subtarget assignments)

1

soluble

No

GBAA0272

47525531

sensor histidine kinase [Bacillus anthra...

501

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04632
(show subtarget assignments)

1

cloned

No

CBU_2005

29655288

rstB

signal transduction histidine kinase-lik...

425

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.2%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP04419
(show subtarget assignments)

1

soluble

No

GBAA2861

47528156

sensor histidine kinase SrrB, putative [...

458

putative drug target function;

Phase 4: April 2009

2C2A

18.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04661
(show subtarget assignments)

1

expressed

No

GBAA0572

47777831

sensor histidine kinase [Bacillus anthra...

416

putative drug target function;

Phase 4: April 2009

2C2A

16.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04667
(show subtarget assignments)

1

cloned

No

GBAA1313

47526578

sensor histidine kinase [Bacillus anthra...

466

putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04243
(show subtarget assignments)

1

soluble

No

CPF_1140

110799522

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04304
(show subtarget assignments)

1

cloned

No

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04401
(show subtarget assignments)

1

expressed

No

VC1831

15641833

sensor histidine kinase [Vibrio cholerae...

736

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.2%

Vibrio cholerae

Regulatory functions

Other

IDP92003
(show subtarget assignments)

8

selected

No

SpneCM_010100002775

298254522

sensor histidine kinase [Streptococcus p...

350

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2C2A

22%

Streptococcus pneumoniae

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP04382
(show subtarget assignments)

1

expressed

No

CPF_0116

110801065

sensor histidine kinase [Clostridium per...

337

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17.8%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04660
(show subtarget assignments)

1

expressed

No

GBAA0286

47777799

sensor histidine kinase, putative [Bacil...

314

putative drug target function;

Phase 4: April 2009

2C2A

24.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04371
(show subtarget assignments)

1

expressed

No

GBAA4776

47778322

sensor histidine kinase [Bacillus anthra...

311

putative drug target function;

Phase 4: April 2009

2C2A

19.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04342
(show subtarget assignments)

1

cloned

No

GBAA1564

47526837

panD

aspartate alpha-decarboxylase [Bacillus ...

127

conserved gene; putative drug target function;

Phase 4: April 2009

2C45

52.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04253
(show subtarget assignments)

1

purified

No

CPF_1800

110800480

prs

phosphoribosylpyrophosphate synthetase [...

364

conserved gene; putative drug target function;

Phase 4: April 2009

2C4K

25.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04473
(show subtarget assignments)

1

expressed

No

YPO2624

115348316

nagD

putative N-acetylglucosamine metabolism ...

250

conserved gene; putative drug target function;

Phase 4: April 2009

2C4N

86%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP91207
(show subtarget assignments)

8

soluble

No

BT_2842

29348251

3-dehydroquinate dehydratase [Bacteroide...

140

potential drug target / Shikimate pathway enzyme

Community Requests

2C4W

49%

Bacteroides thetaiotaomicron

IDP05099
(show subtarget assignments)

1

cloned

No

CD0754

126698334

thiI

thiamine biosynthesis protein ThiI [Clos...

391

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2C5S

42.2%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP04014
(show subtarget assignments)

1

purified

No

YPO3173

115348814

thiI

thiamine biosynthesis protein [Yersinia ...

483

conserved gene; putative drug target function;

Phase 4: April 2009

2C5S

23.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP92032
(show subtarget assignments)

8

selected

No

TGME49_019800

237842869

vacuolar ATP synthase subunit B, putativ...

505

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C61

53.9%

Toxoplasma gondii

IDP05037
(show subtarget assignments)

1

soluble

No

BA_1836

30256106

putative polysaccharide deacetylase [Bac...

234

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C71

27.4%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01724
(show subtarget assignments)

1

expressed

No

GBAA5248

47530553

acetyl-CoA acetyltransferase [Bacillus a...

390

Conserved; Essential; Drug target functions

Phase 3: June 2008

2C7Y

47.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP04666
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1158

47526425

hemH-2

ferrochelatase [Bacillus anthracis str. ...

319

putative drug target function;

Phase 4: April 2009

2C8J

62.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP92077
(show subtarget assignments)

8

selected

No

TGME49_097370

237843739

ruvB-like 1, putative [Toxoplasma gondii...

463

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C9O

62.9%

Toxoplasma gondii

IDP92030
(show subtarget assignments)

8

selected

No

TGME49_019590

237842827

ruvB-like 1, putative [Toxoplasma gondii...

492

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C9O

55.9%

Toxoplasma gondii

IDP02184
(show subtarget assignments)

1

expressed

No

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division

IDP90858
(show subtarget assignments)

8

in_crystallization_trials

No

O31153

30179879

Glutamyl-tRNA synthetase (Glutamate--tRN...

474

Predicted Essential

Community Requests

2CFO

40.2%

Vibrio cholerae

IDP90921
(show subtarget assignments)

8

purified

No

YPO2984

16123165

gltX

glutamyl-tRNA synthetase [Yersinia pesti...

471

Predicted Essential

Community Requests

2CFO

38.4%

Yersinia pestis

IDP90662
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1288c

15792611

gltX

glutamyl-tRNA synthetase [Campylobacter ...

463

Predicted Essential

Community Requests

2CFO

38.9%

Campylobacter jejuni

IDP91972
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100003825

298254730

iron-compound ABC transporter, iron-comp...

321

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2CHU

37.4%

Streptococcus pneumoniae

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP91932
(show subtarget assignments)

8

selected

No

SpneCM_010100007089

298255349

pneumococcal histidine triad protein E [...

189

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2CS7

12.7%

Streptococcus pneumoniae

IDP91924
(show subtarget assignments)

8

selected

No

SpneCM_010100007441

298255419

pneumococcal histidine triad protein B [...

574

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2CS7

5.1%

Streptococcus pneumoniae

IDP91949
(show subtarget assignments)

8

selected

No

SpneCM_010100007099

298255351

pneumococcal histidine triad protein E [...

1039

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2CS7

4.2%

Streptococcus pneumoniae

IDP91818
(show subtarget assignments)

8

cloned

No

b2584

1788938

yfiQ

inhibiting acetyltransferase for acetyl-...

886

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

2CSU

17.3%

Escherichia coli

IDP05574
(show subtarget assignments)

1

soluble

No

SACOL0533

57651372

metS

methionyl-tRNA synthetase [Staphylococcu...

657

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2CSX

35.3%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05320
(show subtarget assignments)

1

cloned

No

lmo0177

16802223

metS

methionyl-tRNA synthetase [Listeria mono...

630

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2CSX

35.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90787
(show subtarget assignments)

8

purified

No

Cj0838c

15792176

metG

methionyl-tRNA synthetase [Campylobacter...

628

Predicted Essential

Community Requests

2CSX

38.5%

Campylobacter jejuni

IDP90854
(show subtarget assignments)

8

crystallized

No

Cj1727c

15793030

metY

putative O-acetylhomoserine (thiol)-lyas...

423

Predicted Essential

Community Requests

2CTZ

40.9%

Campylobacter jejuni

IDP04290
(show subtarget assignments)

1

cloned

No

YPO3099

218930141

manC

mannose-1-phosphate guanylyltransferase ...

470

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2CU2

28.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

IDP01054
(show subtarget assignments)

1

purified

No

STM3363

16766658

yhcO

putative cytoplasmic protein

90

Conserved Gene / Pathway

Phase 2: March 2008

2CX6

76.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP90352
(show subtarget assignments)

8

expressed

No

CT262

15604983

hypothetical protein CT262 [Chlamydia tr...

256

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2CZL

32%

Chlamydia trachomatis

IDP91003
(show subtarget assignments)

8

soluble

No

y1934

22125826

sufA

iron-sulfur cluster assembly scaffold pr...

132

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

2D2A

59.8%

Yersinia pestis