Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90893 (show subtarget assignments)	8	expressed	No	YPO3781	16123915	ubiE	ubiquinone/menaquinone biosynthesis meth...	251	Predicted Essential	Community Requests	2AVN	21.9%	Yersinia pestis

IDP91011 (show subtarget assignments)	8	purified	No	y2255	22126141		hypothetical protein y2255 [Yersinia pes...	251	other biological interest / possibly involved in quorum sensing	Community Requests	1KON	83.3%	Yersinia pestis

IDP04068 (show subtarget assignments)	1	expressed	No	YPCD1.94n	40548799		hypothetical protein YPCD1.94n [Yersinia...	251	virulence factor;	Phase 4: April 2009	1A5V	15.1%	Yersinia pestis

IDP01414 (show subtarget assignments)	1	purified	No	VC1359	15641371		amino acid ABC transporter, ATP-binding ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01340 (show subtarget assignments)	1	expressed	No	VCA0073	15600844		phosphate ABC transporter, ATP-binding p...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	37.1%	Vibrio cholerae	Transport and binding proteins	Anions

IDP91783 (show subtarget assignments)	8	in_pdb 4EBK 4EBJ	No	AAM76670	30171089	ant4'-IIb	aminoglycoside nucleotidyltransferase [P...	251	drug resistance / Aminoglycoside nucleotidyltransferase (ant4'-IIb) gene (aminoglycoside resistanc...	Community Requests	4EBJ	98.8%	Pseudomonas aeruginosa

IDP92062 (show subtarget assignments)	8	selected	No	AAK85305	22073900		putative glutathione/thioredoxin peroxid...	251	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2P5Q	24.7%	Toxoplasma gondii

IDP90521 (show subtarget assignments)	8	in_pdb 3OAM	No	VC1875	15641877		3-deoxy-manno-octulosonate cytidylyltran...	252	Predicted Essential	Community Requests	3OAM	100%	Vibrio cholerae

IDP02782 (show subtarget assignments)	0	work_stopped	No	GBAA4874	161611196	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	252	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4F	94.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91677 (show subtarget assignments)	8	selected	No	FLUAVs7gp1	8486123	M1	matrix protein 1 [Influenza A virus (A/P...	252	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1EA3	65.1%	Influenza A

IDP90922 (show subtarget assignments)	8	in_pdb 3S42 3L2I 3LB0 3M7W 3O1N 3OEX 3NNT	Yes	STM1358	16764709	aroD	3-dehydroquinate dehydratase [Salmonella...	252	Predicted Essential	Community Requests	3L2I	100%	Salmonella enterica

IDP92041 (show subtarget assignments)	8	selected	No	TGME49_039500	237834583		proteasome subunit alpha type 4, subunit...	252	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1IRU	57.9%	Toxoplasma gondii

IDP04452 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1049	42560001		RecName: Full=Undecaprenyl pyrophosphate...	252	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	76.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04647 (show subtarget assignments)	1	purified	No	FTT1127	56604696		Rhodanese-like family protein [Francisel...	252	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YT8	18.3%	Francisella tularensis

IDP92035 (show subtarget assignments)	8	selected	No	ABE76515	92399547	tpi1	triose-phosphate isomerase 1 [Toxoplasma...	252	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1MO0	52.4%	Toxoplasma gondii

IDP00938 (show subtarget assignments)	1	cloned	No	STM0813	16764176	ybhP	putative cytoplasmic protein	252	Essential Gene	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01897 (show subtarget assignments)	1	expressed	No	STM3038	16766339		putative metalloendopeptidase [Salmonell...	252	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2GU1	18.3%	Salmonella enterica	Cell envelope	Other

IDP02573 (show subtarget assignments)	1	in_pdb 3ICC	No	GBAA1847	47527139		short chain dehydrogenase [Bacillus anth...	252	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3ICC	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01779 (show subtarget assignments)	1	soluble	No	CBU_0366	29540977	phoR	sensor histidine kinase PhoR protein, pu...	252	Conserved; Drug target functions	Phase 3: June 2008	2C2A	31.3%	Coxiella burnetii	Signal transduction	Two-component systems

IDP91719 (show subtarget assignments)	8	selected	No	NP_066925	10863909	SPINT2	kunitz-type protease inhibitor 2 isoform...	252	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2ODY	21%	Homo sapiens

IDP02614 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1821	16803861		hypothetical protein lmo1821 [Listeria m...	252	Known virulence-Enzyme ; PMID:15813732	Phase 3: June 2008	2PK0	39.7%	Listeria monocytogenes	Protein fate	Protein modification and repair

IDP90829 (show subtarget assignments)	8	selected	No	S1855	30063207	aroD	3-dehydroquinate dehydratase [Shigella f...	252	Predicted Essential	Community Requests	3L2I	80.2%	Shigella flexneri

IDP01474 (show subtarget assignments)	1	expressed	No	VC2657	15642652		fumarate reductase iron-sulfur subunit	252	Conserved Gene / Pathway	Phase 2: March 2008	1KF6	69%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP00405 (show subtarget assignments)	1	purified	No	YPO4025	16124148		putative iron ABC transporter, ATP-bindi...	252	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.3%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00077 (show subtarget assignments)	0	work_stopped	No	NTL01ST3489	16422154	yhiQ	putative SAM-dependent methyltransferase...	252		Phase 1: October 2007	2PKW	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP02779 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1405c	56708453	gloB	hydroxyacylglutathione hydrolase [Franci...	252	Conserved; Drug target functions	Phase 3: June 2008	2QED	34.1%	Francisella tularensis	Energy metabolism	Other

IDP91457 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_0163	27363646		hypothetical protein VV1_0163 [Vibrio vu...	252	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1NMO	57.9%	Vibrio vulnificus

IDP92063 (show subtarget assignments)	8	selected	No	AAT47116	48857021		putative thioredoxin peroxidase TPX1/1 [...	252	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2P5Q	24.6%	Toxoplasma gondii

IDP02608 (show subtarget assignments)	1	expressed	No	CBU_0178	29540794		ABC transporter, ATP-binding protein [Co...	252	Conserved; Drug target functions	Phase 3: June 2008	1V43	43.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02455 (show subtarget assignments)	1	expressed	No	GBAA3813	47529098		prophage LambdaBa01, thymidylate synthas...	252	Conserved; Drug target functions	Phase 3: June 2008	3AH5	24.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP05009 (show subtarget assignments)	1	soluble	No	BA_4237	30258740		putative lipoprotein [Bacillus anthracis...	253	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP92044 (show subtarget assignments)	8	selected	No	TGME49_042290	237834923		proteasome subunit alpha type 6, putativ...	253	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1IRU	51.4%	Toxoplasma gondii

IDP02131 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1419c	15792737		methyltransferase [Campylobacter jejuni ...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1VE3	18.2%	Campylobacter jejuni	Cell envelope	Other

IDP02130 (show subtarget assignments)	1	cloned	No	Cj1416c	15792734		putative sugar nucleotidyltransferase [C...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	25.7%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01037 (show subtarget assignments)	0	work_stopped	No	STM2927	16766233	surE	stationary phase survival protein SurE	253	potential drug target / Conserved Gene / Pathway	Phase 2: March 2008	2V4N	100%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP02082 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0080	56707259	tpiA	triosephosphate isomerase [Francisella t...	253	Conserved; Drug target functions	Phase 3: June 2008	1TMH	42.7%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00971 (show subtarget assignments)	1	in_pdb 3IAH	Yes	STM1717	16765061	yciK	short chain dehydrogenase	253	Conserved Gene / Pathway	Phase 2: March 2008	3IAH	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP91097 (show subtarget assignments)	0	work_stopped	No	CBU_0479	29541085	kdsB	3-deoxy-D-manno-octulosonate cytidylyltr...	253	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	3TQD	100%	Coxiella burnetii

IDP01888 (show subtarget assignments)	1	cloned	No	GBAA5730	47531066	soJ	sporulation initiation inhibitor protein...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WCV	48.6%	Bacillus anthracis	Regulatory functions	Other

IDP02457 (show subtarget assignments)	1	expressed	No	FTT1248	56708310		ABC transporter, ATP-binding protein [Fr...	253	Drug Target	Phase 3: June 2008	1B0U	31.1%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP05587 (show subtarget assignments)	1	soluble	No	BA_2748	30257353	sleB	spore cortex-lytic enzyme prepeptide [Ba...	253	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3BKH	19.8%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP05062 (show subtarget assignments)	1	purified	No	CD1919	126699529		putative ethanolamine/propanediol utiliz...	253	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02318 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1251	47526517	trpC	indole-3-glycerol-phosphate synthase [Ba...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TSM	40.7%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00709 (show subtarget assignments)	1	purified	No	SACOL0798	57285759		iron compound ABC transporter, ATP-bindi...	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	31.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP91095 (show subtarget assignments)	8	in_pdb 3POL	No	A1S_1557	193077192		3-deoxy-manno-octulosonate cytidylyltran...	253	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	3POL	100%	Acinetobacter baumannii

IDP01161 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4997	30259489		ABC transporter, ATP-binding protein	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP91891 (show subtarget assignments)	8	selected	No	SpneCM_010100007700	298255470		putative glutamine-binding protein precu...	254	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2V25	41.7%	Streptococcus pneumoniae

IDP91774 (show subtarget assignments)	8	in_pdb 4F78	No	AAQ16272	33355852	vanXYG	D,D-dipeptidase/D,D-carboxypeptidase [En...	254	drug resistance / D,D-dipeptidase/D,D-carboxypeptidase	Community Requests			Enterococcus faecalis

IDP02325 (show subtarget assignments)	1	in_pdb 3IMF	No	GBAA4204	47778260		short chain dehydrogenase [Bacillus anth...	254	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3IMF	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP05204 (show subtarget assignments)	1	expressed	No	CD1723	126699329		acyltransferase [Clostridium difficile 6...	254	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00187 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0773	16121086	-	putative thioesterase	254	Virulence	Phase 1: October 2007	3FLA	30.3%	Yersinia pestis	Regulatory functions	Other

IDP00436 (show subtarget assignments)	1	cloned	No	YPO3358	16123508	surE	stationary phase survival protein SurE	254	Conserved Gene / Pathway	Phase 2: March 2008	2V4N	79.9%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00414 (show subtarget assignments)	1	expressed	No	YPO1322	16121604	deoR	DNA-binding transcriptional repressor	254	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01442 (show subtarget assignments)	1	expressed	No	VC2048	15642050		vacJ lipoprotein	254	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP05148 (show subtarget assignments)	1	purified	No	BA_0177	30253685		putative lipoprotein [Bacillus anthracis...	254	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP00149 (show subtarget assignments)	1	expressed	No	VCA0230	15600999	vctC	vibriobactin and enterobactin ABC transp...	254	Virulence	Phase 1: October 2007	2D62	28%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02493 (show subtarget assignments)	1	soluble	No	YPO2048	16122287	cutC	copper homeostasis protein CutC [Yersini...	254	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1TWD	54.3%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01311 (show subtarget assignments)	1	soluble	No	VCA0726	15601482		molybdenum ABC transporter, periplasmic ...	254	Conserved Gene / Pathway	Phase 2: March 2008	1AMF	37.8%	Vibrio cholerae	Transport and binding proteins	Anions

IDP91829 (show subtarget assignments)	8	soluble	No	b3919	1790353	tpiA	triosephosphate isomerase [Escherichia c...	255	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1TRE	99.6%	Escherichia coli

IDP01060 (show subtarget assignments)	1	crystallized	No	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP90649 (show subtarget assignments)	8	cloned	No	Cj1104	15792429		4-diphosphocytidyl-2-C-methyl-D-erythrit...	255	Predicted Essential	Community Requests	2V2Q	29%	Campylobacter jejuni

IDP02670 (show subtarget assignments)	1	cloned	No	GBAA4353	47529649	argB	acetylglutamate kinase [Bacillus anthrac...	255	Conserved; Drug target functions	Phase 3: June 2008	2BTY	43.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP00835 (show subtarget assignments)	1	purified	No	SACOL2685	57286588	cap1C	capsular polysaccharide biosynthesis pro...	255	Conserved Gene / Pathway	Phase 2: March 2008	3QY6	41.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05509 (show subtarget assignments)	1	expressed	No	BA_5736	30260182	spoIIIJ2	stage III sporulation protein J [Bacillu...	255	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Sporulation and germination

IDP02732 (show subtarget assignments)	1	cloned	No	CBU_1982	29542537	ksgA	dimethyladenosine transferase [Coxiella ...	255	Conserved; Drug target functions	Phase 3: June 2008	3TQS	100%	Coxiella burnetii	Protein synthesis	tRNA and rRNA base modification

IDP91440 (show subtarget assignments)	8	expressed	No	VV1_0472	27363939	mepA	penicillin-insensitive murein endopeptid...	255	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1TZP	45.1%	Vibrio vulnificus

IDP04487 (show subtarget assignments)	1	expressed	No	YPO3598	115349219		putative membrane protein [Yersinia pest...	255	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3U66	17.3%	Yersinia pestis	Cell envelope	Other

IDP90163 (show subtarget assignments)	8	in_pdb 3JS3	No	CD2217	172044608	aroD	3-dehydroquinate dehydratase (3-dehydroq...	255	Potential drug target. Shikimate pathway enzyme	Community Requests	3JS3	100%	Clostridium difficile

IDP04735 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1494	115347246	chlN	molybdopterin biosynthesis protein [Yers...	255	conserved gene; putative drug target function;	Phase 4: April 2009	1JW9	67.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP91752 (show subtarget assignments)	8	selected	No	TIP_SHV2C	0			256	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests			Herpesvirus saimiri

IDP01059 (show subtarget assignments)	1	purified	No	STM3509	16766797	bioH	carboxylesterase BioH	256	Drug Target Function	Phase 2: March 2008	1M33	79.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02140 (show subtarget assignments)	1	cloned	No	YPO1629	16121897		N-acetyl-D-glucosamine kinase [Yersinia ...	256	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2AP1	60.2%	Yersinia pestis	Unknown function	General

IDP00218 (show subtarget assignments)	1	expressed	No	YPO2340	16122564	-	conserved hypothetical protein	256	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00219 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1938	16122184	-	probable deoR-family transcriptional reg...	256	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00052 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3500	30258038	bla2	beta-lactamase II	256	Virulence	Phase 1: October 2007	1BC2	81.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP04512 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2342	110798786	modA	molybdate ABC transporter, molybdate-bin...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AMF	33.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP01887 (show subtarget assignments)	1	expressed	No	GBAA5729	47531065	spo0J	stage 0 sporulation protein J [Bacillus ...	256	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	36.3%	Bacillus anthracis	Cellular processes	Sporulation and germination

IDP90639 (show subtarget assignments)	8	cloned	No	Cj0771c	15792109		lipoprotein, NLPA family [Campylobacter ...	256	Predicted Essential	Community Requests	3TQW	39.8%	Campylobacter jejuni

IDP05160 (show subtarget assignments)	1	purified	No	BA_1349	30255287		conserved hypothetical protein [Bacillus...	256	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NLY	35.9%	Bacillus anthracis	Hypothetical proteins: Conserved

IDP02762 (show subtarget assignments)	1	cloned	No	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01741 (show subtarget assignments)	1	cloned	No	Cj1332	15792655	ptmA	flagellin modification protein A [Campyl...	256	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3QIV	30.2%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01699 (show subtarget assignments)	1	purified	No	YPO3343	16123493		extracellular solute-binding protein [Ye...	256	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3KBR	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP04086 (show subtarget assignments)	1	expressed	No	VC2256	15642254		undecaprenyl diphosphate synthase [Vibri...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	54.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00178 (show subtarget assignments)	1	soluble	No	YPO3405	16123554	-	putative ABC transporter, integral membr...	256	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00787 (show subtarget assignments)	0	work_stopped	No	SACOL1016	57284388	fabI	enoyl-(acyl carrier protein) reductase	256	Drug Target Function	Phase 2: March 2008	3GNS	100%	Staphylococcus aureus	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01608 (show subtarget assignments)	1	cloned	No	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	Phase 3: June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP00164 (show subtarget assignments)	1	soluble	No	VC0841	15640858	acfC	accessory colonization factor AcfC	256	Virulence	Phase 1: October 2007	3FIR	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01431 (show subtarget assignments)	1	purified	No	VC1864	15641866		amino acid ABC transporter, ATP-binding ...	256	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	62.9%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90352 (show subtarget assignments)	8	expressed	No	CT262	15604983		hypothetical protein CT262 [Chlamydia tr...	256	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2CZL	32%	Chlamydia trachomatis

IDP01256 (show subtarget assignments)	0	work_stopped	No	BA_1232	30255181	fabI	enoyl-(acyl-carrier-protein) reductase	256	Drug Target Function	Phase 2: March 2008	2QIO	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP05678 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1041	16803081	-	hypothetical protein lmo1041 [Listeria m...	256	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1AMF	30.9%	Listeria monocytogenes	Transport and binding proteins: Cations and iron carrying compounds

IDP02686 (show subtarget assignments)	1	soluble	No	FTT0393	56707542	map	methionine aminopeptidase [Francisella t...	256	Conserved; Drug target functions; Drug target motif	Community Interest	1C21	59.4%	Francisella tularensis	N/A	N/A

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP92034 (show subtarget assignments)	8	selected	No	TGME49_024900	237833733		adenylate kinase, putative [Toxoplasma g...	257	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3TLX	55.6%	Toxoplasma gondii

IDP01077 (show subtarget assignments)	0	work_stopped	No	STM4122	161353577	argB	acetylglutamate kinase	257	Conserved Gene / Pathway	Phase 2: March 2008	1GS5	94.2%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP02180 (show subtarget assignments)	1	cloned	No	Cj0299	15791667		putative periplasmic beta-lactamase [Cam...	257	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	1E3U	34.6%	Campylobacter jejuni	Transport and binding proteins	Anions

IDP05372 (show subtarget assignments)	1	cloned	No	BA_0397	30253932		LPXTG-motif cell wall anchor domain prot...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GHG	24.9%	Bacillus anthracis	Cell envelope: Other

IDP01067 (show subtarget assignments)	1	expressed	No	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP05163 (show subtarget assignments)	1	cloned	No	BA_1719	30256005		putative flagellar basal-body rod protei...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Chemotaxis and motility

IDP90893
(show subtarget assignments)

8

expressed

No

YPO3781

16123915

ubiE

ubiquinone/menaquinone biosynthesis meth...

251

Predicted Essential

Community Requests

2AVN

21.9%

Yersinia pestis

IDP91011
(show subtarget assignments)

8

purified

No

y2255

22126141

hypothetical protein y2255 [Yersinia pes...

251

other biological interest / possibly involved in quorum sensing

Community Requests

1KON

83.3%

Yersinia pestis

IDP04068
(show subtarget assignments)

1

expressed

No

YPCD1.94n

40548799

hypothetical protein YPCD1.94n [Yersinia...

251

virulence factor;

Phase 4: April 2009

1A5V

15.1%

Yersinia pestis

IDP01414
(show subtarget assignments)

1

purified

No

VC1359

15641371

amino acid ABC transporter, ATP-binding ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01340
(show subtarget assignments)

1

expressed

No

VCA0073

15600844

phosphate ABC transporter, ATP-binding p...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

37.1%

Vibrio cholerae

Transport and binding proteins

Anions

IDP91783
(show subtarget assignments)

8

in_pdb
4EBK
4EBJ

No

AAM76670

30171089

ant4'-IIb

aminoglycoside nucleotidyltransferase [P...

251

drug resistance / Aminoglycoside nucleotidyltransferase (ant4'-IIb) gene (aminoglycoside resistanc...

Community Requests

4EBJ

98.8%

Pseudomonas aeruginosa

IDP92062
(show subtarget assignments)

8

selected

No

AAK85305

22073900

putative glutathione/thioredoxin peroxid...

251

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2P5Q

24.7%

Toxoplasma gondii

IDP90521
(show subtarget assignments)

8

in_pdb
3OAM

No

VC1875

15641877

3-deoxy-manno-octulosonate cytidylyltran...

252

Predicted Essential

Community Requests

3OAM

100%

Vibrio cholerae

IDP02782
(show subtarget assignments)

0

work_stopped

No

GBAA4874

161611196

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

252

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4F

94.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91677
(show subtarget assignments)

8

selected

No

FLUAVs7gp1

8486123

M1

matrix protein 1 [Influenza A virus (A/P...

252

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1EA3

65.1%

Influenza A

IDP90922
(show subtarget assignments)

8

in_pdb
3S42
3L2I
3LB0
3M7W
3O1N
3OEX
3NNT

Yes

STM1358

16764709

aroD

3-dehydroquinate dehydratase [Salmonella...

252

Predicted Essential

Community Requests

3L2I

100%

Salmonella enterica

IDP92041
(show subtarget assignments)

8

selected

No

TGME49_039500

237834583

proteasome subunit alpha type 4, subunit...

252

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1IRU

57.9%

Toxoplasma gondii

IDP04452
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1049

42560001

RecName: Full=Undecaprenyl pyrophosphate...

252

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

76.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04647
(show subtarget assignments)

1

purified

No

FTT1127

56604696

Rhodanese-like family protein [Francisel...

252

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YT8

18.3%

Francisella tularensis

IDP92035
(show subtarget assignments)

8

selected

No

ABE76515

92399547

tpi1

triose-phosphate isomerase 1 [Toxoplasma...

252

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1MO0

52.4%

Toxoplasma gondii

IDP00938
(show subtarget assignments)

1

cloned

No

STM0813

16764176

ybhP

putative cytoplasmic protein

252

Essential Gene

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01897
(show subtarget assignments)

1

expressed

No

STM3038

16766339

putative metalloendopeptidase [Salmonell...

252

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2GU1

18.3%

Salmonella enterica

Cell envelope

Other

IDP02573
(show subtarget assignments)

1

in_pdb
3ICC

No

GBAA1847

47527139

short chain dehydrogenase [Bacillus anth...

252

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3ICC

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01779
(show subtarget assignments)

1

soluble

No

CBU_0366

29540977

phoR

sensor histidine kinase PhoR protein, pu...

252

Conserved; Drug target functions

Phase 3: June 2008

2C2A

31.3%

Coxiella burnetii

Signal transduction

Two-component systems

IDP91719
(show subtarget assignments)

8

selected

No

NP_066925

10863909

SPINT2

kunitz-type protease inhibitor 2 isoform...

252

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2ODY

21%

Homo sapiens

IDP02614
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1821

16803861

hypothetical protein lmo1821 [Listeria m...

252

Known virulence-Enzyme ; PMID:15813732

Phase 3: June 2008

2PK0

39.7%

Listeria monocytogenes

Protein fate

Protein modification and repair

IDP90829
(show subtarget assignments)

8

selected

No

S1855

30063207

aroD

3-dehydroquinate dehydratase [Shigella f...

252

Predicted Essential

Community Requests

3L2I

80.2%

Shigella flexneri

IDP01474
(show subtarget assignments)

1

expressed

No

VC2657

15642652

fumarate reductase iron-sulfur subunit

252

Conserved Gene / Pathway

Phase 2: March 2008

1KF6

69%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP00405
(show subtarget assignments)

1

purified

No

YPO4025

16124148

putative iron ABC transporter, ATP-bindi...

252

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.3%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00077
(show subtarget assignments)

0

work_stopped

No

NTL01ST3489

16422154

yhiQ

putative SAM-dependent methyltransferase...

252

Phase 1: October 2007

2PKW

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP02779
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1405c

56708453

gloB

hydroxyacylglutathione hydrolase [Franci...

252

Conserved; Drug target functions

Phase 3: June 2008

2QED

34.1%

Francisella tularensis

Energy metabolism

Other

IDP91457
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_0163

27363646

hypothetical protein VV1_0163 [Vibrio vu...

252

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1NMO

57.9%

Vibrio vulnificus

IDP92063
(show subtarget assignments)

8

selected

No

AAT47116

48857021

putative thioredoxin peroxidase TPX1/1 [...

252

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2P5Q

24.6%

Toxoplasma gondii

IDP02608
(show subtarget assignments)

1

expressed

No

CBU_0178

29540794

ABC transporter, ATP-binding protein [Co...

252

Conserved; Drug target functions

Phase 3: June 2008

1V43

43.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02455
(show subtarget assignments)

1

expressed

No

GBAA3813

47529098

prophage LambdaBa01, thymidylate synthas...

252

Conserved; Drug target functions

Phase 3: June 2008

3AH5

24.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP05009
(show subtarget assignments)

1

soluble

No

BA_4237

30258740

putative lipoprotein [Bacillus anthracis...

253

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP92044
(show subtarget assignments)

8

selected

No

TGME49_042290

237834923

proteasome subunit alpha type 6, putativ...

253

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1IRU

51.4%

Toxoplasma gondii

IDP02131
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1419c

15792737

methyltransferase [Campylobacter jejuni ...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1VE3

18.2%

Campylobacter jejuni

Cell envelope

Other

IDP02130
(show subtarget assignments)

1

cloned

No

Cj1416c

15792734

putative sugar nucleotidyltransferase [C...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

25.7%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01037
(show subtarget assignments)

0

work_stopped

No

STM2927

16766233

surE

stationary phase survival protein SurE

253

potential drug target / Conserved Gene / Pathway

Phase 2: March 2008

2V4N

100%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP02082
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0080

56707259

tpiA

triosephosphate isomerase [Francisella t...

253

Conserved; Drug target functions

Phase 3: June 2008

1TMH

42.7%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00971
(show subtarget assignments)

1

in_pdb
3IAH

Yes

STM1717

16765061

yciK

short chain dehydrogenase

253

Conserved Gene / Pathway

Phase 2: March 2008

3IAH

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP91097
(show subtarget assignments)

0

work_stopped

No

CBU_0479

29541085

kdsB

3-deoxy-D-manno-octulosonate cytidylyltr...

253

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

3TQD

100%

Coxiella burnetii

IDP01888
(show subtarget assignments)

1

cloned

No

GBAA5730

47531066

soJ

sporulation initiation inhibitor protein...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WCV

48.6%

Bacillus anthracis

Regulatory functions

Other

IDP02457
(show subtarget assignments)

1

expressed

No

FTT1248

56708310

ABC transporter, ATP-binding protein [Fr...

253

Drug Target

Phase 3: June 2008

1B0U

31.1%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP05587
(show subtarget assignments)

1

soluble

No

BA_2748

30257353

sleB

spore cortex-lytic enzyme prepeptide [Ba...

253

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3BKH

19.8%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP05062
(show subtarget assignments)

1

purified

No

CD1919

126699529

putative ethanolamine/propanediol utiliz...

253

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02318
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1251

47526517

trpC

indole-3-glycerol-phosphate synthase [Ba...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TSM

40.7%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00709
(show subtarget assignments)

1

purified

No

SACOL0798

57285759

iron compound ABC transporter, ATP-bindi...

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

31.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP91095
(show subtarget assignments)

8

in_pdb
3POL

No

A1S_1557

193077192

3-deoxy-manno-octulosonate cytidylyltran...

253

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

3POL

100%

Acinetobacter baumannii

IDP01161
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4997

30259489

ABC transporter, ATP-binding protein

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP91891
(show subtarget assignments)

8

selected

No

SpneCM_010100007700

298255470

putative glutamine-binding protein precu...

254

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2V25

41.7%

Streptococcus pneumoniae

IDP91774
(show subtarget assignments)

8

in_pdb
4F78

No

AAQ16272

33355852

vanXYG

D,D-dipeptidase/D,D-carboxypeptidase [En...

254

drug resistance / D,D-dipeptidase/D,D-carboxypeptidase

Community Requests

Enterococcus faecalis

IDP02325
(show subtarget assignments)

1

in_pdb
3IMF

No

GBAA4204

47778260

short chain dehydrogenase [Bacillus anth...

254

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3IMF

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP05204
(show subtarget assignments)

1

expressed

No

CD1723

126699329

acyltransferase [Clostridium difficile 6...

254

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00187
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0773

16121086

-

putative thioesterase

254

Virulence

Phase 1: October 2007

3FLA

30.3%

Yersinia pestis

Regulatory functions

Other

IDP00436
(show subtarget assignments)

1

cloned

No

YPO3358

16123508

surE

stationary phase survival protein SurE

254

Conserved Gene / Pathway

Phase 2: March 2008

2V4N

79.9%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00414
(show subtarget assignments)

1

expressed

No

YPO1322

16121604

deoR

DNA-binding transcriptional repressor

254

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01442
(show subtarget assignments)

1

expressed

No

VC2048

15642050

vacJ lipoprotein

254

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP05148
(show subtarget assignments)

1

purified

No

BA_0177

30253685

putative lipoprotein [Bacillus anthracis...

254

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP00149
(show subtarget assignments)

1

expressed

No

VCA0230

15600999

vctC

vibriobactin and enterobactin ABC transp...

254

Virulence

Phase 1: October 2007

2D62

28%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02493
(show subtarget assignments)

1

soluble

No

YPO2048

16122287

cutC

copper homeostasis protein CutC [Yersini...

254

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1TWD

54.3%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01311
(show subtarget assignments)

1

soluble

No

VCA0726

15601482

molybdenum ABC transporter, periplasmic ...

254

Conserved Gene / Pathway

Phase 2: March 2008

1AMF

37.8%

Vibrio cholerae

Transport and binding proteins

Anions

IDP91829
(show subtarget assignments)

8

soluble

No

b3919

1790353

tpiA

triosephosphate isomerase [Escherichia c...

255

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1TRE

99.6%

Escherichia coli

IDP01060
(show subtarget assignments)

1

crystallized

No

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP90649
(show subtarget assignments)

8

cloned

No

Cj1104

15792429

4-diphosphocytidyl-2-C-methyl-D-erythrit...

255

Predicted Essential

Community Requests

2V2Q

29%

Campylobacter jejuni

IDP02670
(show subtarget assignments)

1

cloned

No

GBAA4353

47529649

argB

acetylglutamate kinase [Bacillus anthrac...

255

Conserved; Drug target functions

Phase 3: June 2008

2BTY

43.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP00835
(show subtarget assignments)

1

purified

No

SACOL2685

57286588

cap1C

capsular polysaccharide biosynthesis pro...

255

Conserved Gene / Pathway

Phase 2: March 2008

3QY6

41.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05509
(show subtarget assignments)

1

expressed

No

BA_5736

30260182

spoIIIJ2

stage III sporulation protein J [Bacillu...

255

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP02732
(show subtarget assignments)

1

cloned

No

CBU_1982

29542537

ksgA

dimethyladenosine transferase [Coxiella ...

255

Conserved; Drug target functions

Phase 3: June 2008

3TQS

100%

Coxiella burnetii

Protein synthesis

tRNA and rRNA base modification

IDP91440
(show subtarget assignments)

8

expressed

No

VV1_0472

27363939

mepA

penicillin-insensitive murein endopeptid...

255

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1TZP

45.1%

Vibrio vulnificus

IDP04487
(show subtarget assignments)

1

expressed

No

YPO3598

115349219

putative membrane protein [Yersinia pest...

255

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3U66

17.3%

Yersinia pestis

Cell envelope

Other

IDP90163
(show subtarget assignments)

8

in_pdb
3JS3

No

CD2217

172044608

aroD

3-dehydroquinate dehydratase (3-dehydroq...

255

Potential drug target. Shikimate pathway enzyme

Community Requests

3JS3

100%

Clostridium difficile

IDP04735
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1494

115347246

chlN

molybdopterin biosynthesis protein [Yers...

255

conserved gene; putative drug target function;

Phase 4: April 2009

1JW9

67.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP91752
(show subtarget assignments)

8

selected

No

TIP_SHV2C

0

256

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

Herpesvirus saimiri

IDP01059
(show subtarget assignments)

1

purified

No

STM3509

16766797

bioH

carboxylesterase BioH

256

Drug Target Function

Phase 2: March 2008

1M33

79.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02140
(show subtarget assignments)

1

cloned

No

YPO1629

16121897

N-acetyl-D-glucosamine kinase [Yersinia ...

256

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2AP1

60.2%

Yersinia pestis

Unknown function

General

IDP00218
(show subtarget assignments)

1

expressed

No

YPO2340

16122564

-

conserved hypothetical protein

256

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00219
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1938

16122184

-

probable deoR-family transcriptional reg...

256

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00052
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3500

30258038

bla2

beta-lactamase II

256

Virulence

Phase 1: October 2007

1BC2

81.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP04512
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2342

110798786

modA

molybdate ABC transporter, molybdate-bin...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AMF

33.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP01887
(show subtarget assignments)

1

expressed

No

GBAA5729

47531065

spo0J

stage 0 sporulation protein J [Bacillus ...

256

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

36.3%

Bacillus anthracis

Cellular processes

Sporulation and germination

IDP90639
(show subtarget assignments)

8

cloned

No

Cj0771c

15792109

lipoprotein, NLPA family [Campylobacter ...

256

Predicted Essential

Community Requests

3TQW

39.8%

Campylobacter jejuni

IDP05160
(show subtarget assignments)

1

purified

No

BA_1349

30255287

conserved hypothetical protein [Bacillus...

256

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NLY

35.9%

Bacillus anthracis

Hypothetical proteins: Conserved

IDP02762
(show subtarget assignments)

1

cloned

No

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01741
(show subtarget assignments)

1

cloned

No

Cj1332

15792655

ptmA

flagellin modification protein A [Campyl...

256

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3QIV

30.2%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01699
(show subtarget assignments)

1

purified

No

YPO3343

16123493

extracellular solute-binding protein [Ye...

256

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3KBR

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP04086
(show subtarget assignments)

1

expressed

No

VC2256

15642254

undecaprenyl diphosphate synthase [Vibri...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

54.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00178
(show subtarget assignments)

1

soluble

No

YPO3405

16123554

-

putative ABC transporter, integral membr...

256

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00787
(show subtarget assignments)

0

work_stopped

No

SACOL1016

57284388

fabI

enoyl-(acyl carrier protein) reductase

256

Drug Target Function

Phase 2: March 2008

3GNS

100%

Staphylococcus aureus

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01608
(show subtarget assignments)

1

cloned

No

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

Phase 3: June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP00164
(show subtarget assignments)

1

soluble

No

VC0841

15640858

acfC

accessory colonization factor AcfC

256

Virulence

Phase 1: October 2007

3FIR

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01431
(show subtarget assignments)

1

purified

No

VC1864

15641866

amino acid ABC transporter, ATP-binding ...

256

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

62.9%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90352
(show subtarget assignments)

8

expressed

No

CT262

15604983

hypothetical protein CT262 [Chlamydia tr...

256

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2CZL

32%

Chlamydia trachomatis

IDP01256
(show subtarget assignments)

0

work_stopped

No

BA_1232

30255181

fabI

enoyl-(acyl-carrier-protein) reductase

256

Drug Target Function

Phase 2: March 2008

2QIO

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP05678
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1041

16803081

-

hypothetical protein lmo1041 [Listeria m...

256

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1AMF

30.9%

Listeria monocytogenes

Transport and binding proteins: Cations and iron carrying compounds

IDP02686
(show subtarget assignments)

1

soluble

No

FTT0393

56707542

map

methionine aminopeptidase [Francisella t...

256

Conserved; Drug target functions; Drug target motif

Community Interest

1C21

59.4%

Francisella tularensis

N/A

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP92034
(show subtarget assignments)

8

selected

No

TGME49_024900

237833733

adenylate kinase, putative [Toxoplasma g...

257

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3TLX

55.6%

Toxoplasma gondii

IDP01077
(show subtarget assignments)

0

work_stopped

No

STM4122

161353577

argB

acetylglutamate kinase

257

Conserved Gene / Pathway

Phase 2: March 2008

1GS5

94.2%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP02180
(show subtarget assignments)

1

cloned

No

Cj0299

15791667

putative periplasmic beta-lactamase [Cam...

257

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

1E3U

34.6%

Campylobacter jejuni

Transport and binding proteins

Anions

IDP05372
(show subtarget assignments)

1

cloned

No

BA_0397

30253932

LPXTG-motif cell wall anchor domain prot...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GHG

24.9%

Bacillus anthracis

Cell envelope: Other

IDP01067
(show subtarget assignments)

1

expressed

No

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP05163
(show subtarget assignments)

1

cloned

No

BA_1719

30256005

putative flagellar basal-body rod protei...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Chemotaxis and motility