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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 20 of 60, showing 100 records out of 5973 total, starting on record 1901
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02708
(
show subtarget assignments
)
1
cloned
No
lmo0291
16802337
hypothetical protein lmo0291 [Listeria m...
276
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2DKF
13.4%
Listeria monocytogenes
Cellular processes
Toxin production and resistance
IDP01061
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM3591
16766877
uspA
universal stress protein A
144
Conserved Gene / Pathway
Phase 2: March 2008
1JMV
66.7%
Salmonella enterica
Cellular processes
Adaptations to atypical conditions
IDP02153
(
show subtarget assignments
)
1
expressed
No
CBU_0884
29541475
bipA
virulence regulator BipA [Coxiella burne...
602
Conserved; Drug target functions
Phase 3: June 2008
3E3X
34.6%
Coxiella burnetii
Cellular processes
Pathogenesis
IDP02146
(
show subtarget assignments
)
1
cloned
No
Cj1426c
15792744
hypothetical protein Cj1426c [Campylobac...
283
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Cellular processes
Other
IDP00557
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3382
16123531
gsrA
serine endoprotease
481
Virulence Associated Factor
Phase 2: March 2008
2ZLE
71.9%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP01055
(
show subtarget assignments
)
1
crystallized
No
STM3371
16766666
maf
Maf-like protein
197
Conserved Gene / Pathway
Phase 2: March 2008
1EX2
43.7%
Salmonella enterica
Cellular processes
Cell division
IDP00006
(
show subtarget assignments
)
1
soluble
No
BA_0672
30254271
immune inhibitor A metalloprotease
799
Virulence/Drug Target Homolog
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04019
(
show subtarget assignments
)
1
cloned
No
CPF_2080
110799586
spoIIIAH
stage III sporulation protein AH [Clostr...
165
conserved gene; putative drug target function;
Phase 4: April 2009
3TUF
24.2%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP01047
(
show subtarget assignments
)
1
cloned
No
STM3152
16766452
putative methyl-accepting chemotaxis pro...
547
Conserved Gene / Pathway
Phase 2: March 2008
3ZX6
34.7%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01046
(
show subtarget assignments
)
1
expressed
No
STM3138
16766438
putative methyl-accepting chemotaxis pro...
352
Conserved Gene / Pathway
Phase 2: March 2008
1QU7
16.8%
Salmonella enterica
Cellular processes
Other
IDP00059
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4013
30258522
fibronectin/fibrinogen-binding protein, ...
569
Virulence
Phase 1: October 2007
3DOA
22.5%
Bacillus anthracis
Cellular processes
Pathogenesis
IDP04020
(
show subtarget assignments
)
1
cloned
No
CPF_2112
110800515
cell division protein FtsQ [Clostridium ...
248
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Cell division
IDP00549
(
show subtarget assignments
)
1
purified
No
YPO3814
16123948
ftsY
cell division protein
541
Conserved Gene / Pathway
Phase 2: March 2008
2YHS
63.7%
Yersinia pestis
Cellular processes
Cell division
IDP02110
(
show subtarget assignments
)
1
expressed
No
STM3820
16767105
putative cytochrome c peroxidase [Salmon...
466
Conserved; Drug target functions
Phase 3: June 2008
1IQC
29.4%
Salmonella enterica
Cellular processes
Detoxification
IDP01037
(
show subtarget assignments
)
0
work_stopped
No
STM2927
16766233
surE
stationary phase survival protein SurE
253
potential drug target /
Conserved Gene / Pathway
Phase 2: March 2008
2V4N
100%
Salmonella enterica
Cellular processes
Adaptations to atypical conditions
IDP01036
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM2897
16766203
invE
invasion protein
372
Conserved Gene / Pathway
Phase 2: March 2008
2VJ5
26.1%
Salmonella enterica
Cellular processes
Pathogenesis
IDP00547
(
show subtarget assignments
)
1
expressed
No
YPO3813
16123947
ftsE
cell division protein FtsE
222
Conserved Gene / Pathway
Phase 2: March 2008
3DHW
39.6%
Yersinia pestis
Cellular processes
Cell division
IDP02098
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0187
56707352
ftsA
cell division protein FtsA [Francisella ...
420
Conserved; Drug target functions
Phase 3: June 2008
1E4F
24%
Francisella tularensis
Cellular processes
Cell division
IDP04727
(
show subtarget assignments
)
1
purified
No
CPF_2072
110800396
hemolysin A [Clostridium perfringens ATC...
271
conserved gene; putative drug target function;
Phase 4: April 2009
3HP7
49.8%
Clostridium perfringens
Cellular processes
Toxin production and resistance
IDP00545
(
show subtarget assignments
)
1
cloned
No
YPO2747
16122951
fadJ
multifunctional fatty acid oxidation com...
774
Conserved Gene / Pathway
Phase 2: March 2008
1WDK
34.1%
Yersinia pestis
Cellular processes
Detoxification
IDP00544
(
show subtarget assignments
)
1
purified
No
YPO2746
16122950
fadI
3-ketoacyl-CoA thiolase
436
Virulence Associated Factor
Phase 2: March 2008
1ULQ
37.4%
Yersinia pestis
Cellular processes
Detoxification
IDP02090
(
show subtarget assignments
)
1
cloned
No
STM3577
16766863
tcp
methyl-accepting transmembrane citrate/p...
547
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
40%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01029
(
show subtarget assignments
)
0
work_stopped
No
STM1916
16765258
cheY
chemotaxis regulator transmitting signal...
129
Conserved Gene / Pathway
Phase 2: March 2008
2FKA
100%
Salmonella enterica
Cellular processes
Other
IDP00058
(
show subtarget assignments
)
1
soluble
No
BA_3903
30258417
bacteriocin ABC transporter, ATP-binding...
234
Virulence
Phase 1: October 2007
1OXS
32.3%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00029
(
show subtarget assignments
)
1
purified
No
BA_0404
30253939
tellurite resistance protein, putative
360
Virulence
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00540
(
show subtarget assignments
)
1
purified
No
YPO2719
16122923
era
GTP-binding protein Era
303
Conserved Gene / Pathway
Phase 2: March 2008
1EGA
83.8%
Yersinia pestis
Cellular processes
Cell division
IDP02076
(
show subtarget assignments
)
1
soluble
No
STM3216
16766515
putative methyl-accepting chemotaxis pro...
521
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
28.6%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00115
(
show subtarget assignments
)
1
crystallized
No
NT01VPA0514
28900406
VPA0551
hypothetical protein VPA0551 (gi 2890040...
181
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2OT9
33.7%
Vibrio parahaemolyticus
Cellular processes
Toxin production and resistance
IDP04040
(
show subtarget assignments
)
1
cloned
No
CPF_1068
110800949
cotJC
spore coat protein CotJC [Clostridium pe...
188
conserved gene; putative drug target function;
Phase 4: April 2009
1JKU
34.9%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP01020
(
show subtarget assignments
)
1
expressed
No
STM2110
16765440
wcaF
putative colanic acid biosynthesis acety...
184
Essential Gene
Phase 2: March 2008
3SRT
26.1%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP02677
(
show subtarget assignments
)
1
cloned
No
FTT0879
56707983
sodC
superoxide dismuate (Cu-Zn) precusor [Fr...
185
Drug Target
Phase 3: June 2008
1EQW
50.3%
Francisella tularensis
Cellular processes
Detoxification
IDP00057
(
show subtarget assignments
)
1
soluble
No
BA_3900
30258414
lantibiotic biosynthesis DNA-binding res...
220
Virulence
Phase 1: October 2007
2GWR
34.1%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00028
(
show subtarget assignments
)
1
purified
No
BA_0401
30253936
tellurium resistance protein
194
Virulence
Phase 1: October 2007
2KXT
57.7%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04701
(
show subtarget assignments
)
1
expressed
No
YPO0270
115346088
putative type III secretion apparatus pr...
216
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Cellular processes
Pathogenesis
IDP02048
(
show subtarget assignments
)
1
expressed
No
STM3737
16767022
putative Zn-dependent hydrolase [Salmone...
293
Conserved; Drug target functions
Phase 3: June 2008
1JT1
30.7%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP01008
(
show subtarget assignments
)
1
soluble
No
STM2533
16765853
sseA
3-mercaptopyruvate sulfurtransferase
280
Conserved Gene / Pathway
Phase 2: March 2008
1URH
79.6%
Salmonella enterica
Cellular processes
Detoxification
IDP00531
(
show subtarget assignments
)
1
cloned
No
YPO2737
16122941
ccmD
putative heme exporter protein D
100
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Other
IDP00530
(
show subtarget assignments
)
1
cloned
No
YPO2736
16122940
ccmC
putative heme exporter protein C
245
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Other
IDP00113
(
show subtarget assignments
)
0
work_stopped
No
NT01SAA0015
16119212
blaI
PENICILLINASE REPRESSOR
126
Virulence
Phase 1: October 2007
1SD4
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP00997
(
show subtarget assignments
)
1
soluble
No
STM2314
16765641
putative chemotaxis signal transduction ...
333
Conserved Gene / Pathway
Phase 2: March 2008
1K68
12%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP02020
(
show subtarget assignments
)
1
crystallized
No
FTT0245
56707402
usp
universal stress protein [Francisella tu...
278
Drug Target
Phase 3: June 2008
2PFS
20.5%
Francisella tularensis
Cellular processes
Adaptations to atypical conditions
IDP00056
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_3898
30258412
choloylglycine hydrolase family protein ...
328
Virulence
Phase 1: October 2007
2OQC
48.8%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04011
(
show subtarget assignments
)
1
cloned
No
CPF_2475
110800353
stage II sporulation protein R [Clostrid...
209
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP00524
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0490
16120820
apaH
diadenosine tetraphosphatase
289
Conserved Gene / Pathway
Phase 2: March 2008
2DFJ
73.7%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP04012
(
show subtarget assignments
)
1
cloned
No
CPF_2355
110800506
virJ
sensor histidine kinase [Clostridium per...
482
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
15.4%
Clostridium perfringens
Cellular processes
Pathogenesis
IDP00522
(
show subtarget assignments
)
1
soluble
No
YPO3423
16123572
ampD
N-acetyl-anhydromuranmyl-L-alanine amida...
183
Conserved Gene / Pathway
Phase 2: March 2008
1J3G
62.3%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP02004
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0994c
56708086
MRP like protein [Francisella tularensis...
286
Conserved; Drug target functions
Phase 3: June 2008
2PH1
35.3%
Francisella tularensis
Cellular processes
Cell division
IDP00111
(
show subtarget assignments
)
1
in_pdb
3TV9
No
NT02SF4808
30043741
pmbA
putative peptide maturation protein
450
Virulence
Phase 1: October 2007
3TV9
96.2%
Shigella flexneri
Cellular processes
Toxin production and resistance
IDP00518
(
show subtarget assignments
)
1
cloned
No
YPO1566
16121836
putative hydrolase
280
Virulence Associated Factor
Phase 2: March 2008
3QDF
31.8%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00980
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1970
16765308
fliG
flagellar motor switch protein G
331
Conserved Gene / Pathway
Phase 2: March 2008
3HJL
28.7%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00055
(
show subtarget assignments
)
0
work_stopped
No
BA_3696
30258217
blasticidin S deaminase, putative
142
Virulence
Phase 1: October 2007
3B8F
99.3%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00517
(
show subtarget assignments
)
1
soluble
No
YPMT1.71
16082863
hypothetical protein YPMT1.71
328
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP00975
(
show subtarget assignments
)
1
cloned
No
STM1815
16765156
minD
cell division inhibitor MinD
270
Conserved Gene / Pathway
Phase 2: March 2008
3Q9L
93.3%
Salmonella enterica
Cellular processes
Cell division
IDP01981
(
show subtarget assignments
)
1
soluble
No
STM1969
16765307
fliF
flagellar MS-ring protein [Salmonella ty...
560
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP02312
(
show subtarget assignments
)
1
expressed
No
GBAA2190
47778017
FtsK/SpoIIIE family protein [Bacillus an...
1342
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2IUT
7.4%
Bacillus anthracis
Cellular processes
Cell division
IDP01977
(
show subtarget assignments
)
1
cloned
No
Cj1444c
15792762
kpsD
capsular polysaccharide ABC transporter,...
552
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Cellular processes
Other
IDP00027
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_0400
30253935
tellurium resistance protein
194
Virulence
Phase 1: October 2007
2KXT
56.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04016
(
show subtarget assignments
)
1
in_crystallization_trials
No
CPF_0834
110798754
arsC
arsenate reductase ArsC [Clostridium per...
132
conserved gene; putative drug target function;
Phase 4: April 2009
2L17
40.9%
Clostridium perfringens
Cellular processes
Detoxification
IDP00514
(
show subtarget assignments
)
1
selected
No
YPO3721
16123859
hemolysin
1635
Conserved Gene / Pathway
Phase 2: March 2008
3FY3
9%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00970
(
show subtarget assignments
)
1
soluble
No
STM1682
16765025
tpx
thiol peroxidase
168
Conserved Gene / Pathway
Phase 2: March 2008
1QXH
87.5%
Salmonella enterica
Cellular processes
Detoxification
IDP00513
(
show subtarget assignments
)
1
cloned
No
YPO3674
16123817
putative insecticidal toxin
1011
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP04101
(
show subtarget assignments
)
1
purified
No
CPF_2392
110799105
minE
cell division topological specificity fa...
90
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Cell division
IDP00511
(
show subtarget assignments
)
1
in_pdb
3RPE
No
YPO0670
16120995
mdaB
putative modulator of drug activity
194
Conserved Gene / Pathway
Phase 2: March 2008
3RPE
100%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP04010
(
show subtarget assignments
)
1
cloned
No
CPF_2393
110798628
minD
septum site-determining protein MinD [Cl...
265
conserved gene; putative drug target function;
Phase 4: April 2009
3Q9L
43.4%
Clostridium perfringens
Cellular processes
Cell division
IDP00054
(
show subtarget assignments
)
1
crystallized
No
BA_3600
30258128
acetyltransferase, CYSE/LACA/LPXA/NODL f...
185
Virulence
Phase 1: October 2007
1KHR
42.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP01957
(
show subtarget assignments
)
1
expressed
No
STM1657
16765001
putative methyl-accepting chemotaxis pro...
384
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
32.6%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP02654
(
show subtarget assignments
)
1
cloned
No
Cj1682c
15792986
gltA
citrate synthase [Campylobacter jejuni s...
422
Possible Vaccine Candidate; Predicted Essential-Modeling
Phase 3: June 2008
2H12
50.2%
Campylobacter jejuni
Cellular processes
Chemotaxis and motility
IDP01955
(
show subtarget assignments
)
1
cloned
No
STM1980
16765318
fliQ
flagellar biosynthesis protein FliQ [Sal...
89
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00508
(
show subtarget assignments
)
1
expressed
No
YPO1315
16121597
putative hydrolase
216
Conserved Gene / Pathway
Phase 2: March 2008
3FVV
35.2%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP01940
(
show subtarget assignments
)
1
cloned
No
STM1626
16764970
trg
methyl-accepting chemotaxis protein III ...
541
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
35.5%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00954
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1189
16764544
maf
Maf-like protein
194
Essential Gene
Phase 2: March 2008
1EX2
31.4%
Salmonella enterica
Cellular processes
Cell division
IDP00953
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1183
16764539
flgK
flagellar hook-associated protein FlgK
553
Conserved Gene / Pathway
Phase 2: March 2008
2D4Y
83.5%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP00053
(
show subtarget assignments
)
1
soluble
No
BA_3536
30258071
phenazine biosynthesis protein, PhzF fam...
285
Virulence
Phase 1: October 2007
1QY9
31.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00106
(
show subtarget assignments
)
0
work_stopped
No
NT01SF3707
30042635
mdaB
modulator of drug activity B
193
Virulence
Phase 1: October 2007
2AMJ
97.9%
Shigella flexneri
Cellular processes
Toxin production and resistance
IDP00503
(
show subtarget assignments
)
1
purified
No
YPO3766
16123902
fadB
multifunctional fatty acid oxidation com...
729
Virulence Associated Factor
Phase 2: March 2008
1WDK
55.1%
Yersinia pestis
Cellular processes
Detoxification
IDP00502
(
show subtarget assignments
)
1
selected
No
YPO2045
16122284
putative hemolysin
1576
Conserved Gene / Pathway
Phase 2: March 2008
3FY3
5.6%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00214
(
show subtarget assignments
)
1
expressed
No
YPO2252
16122476
-
putative toxin transport protein
712
Virulence
Phase 1: October 2007
2YL4
26.1%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP01924
(
show subtarget assignments
)
1
purified
No
lmo0692
16802734
cheA
two-component sensor histidine kinase Ch...
618
Known virulence-Regulation; PMID:15155625
Phase 3: June 2008
1B3Q
26.5%
Listeria monocytogenes
Cellular processes
Chemotaxis and motility
IDP00943
(
show subtarget assignments
)
1
crystallized
No
STM0862
16764224
yliJ
putative glutathione S-transferase
208
Conserved Gene / Pathway
Phase 2: March 2008
4ECI
30.8%
Salmonella enterica
Cellular processes
Detoxification
IDP00500
(
show subtarget assignments
)
1
purified
No
YPO1784
16122038
putative copper resistance protein
128
Conserved Gene / Pathway
Phase 2: March 2008
1IX2
31.2%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP04697
(
show subtarget assignments
)
1
soluble
No
YPCD1.29c
16082717
yopB
secreted effector protein [Yersinia pest...
401
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP00052
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_3500
30258038
bla2
beta-lactamase II
256
Virulence
Phase 1: October 2007
1BC2
81.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00212
(
show subtarget assignments
)
1
expressed
No
YPO2123
16122358
-
putative phage minor tail protein
236
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP02634
(
show subtarget assignments
)
1
cloned
No
Cj1125c
15792450
wlaG
general glycosylation pathway protein [C...
376
Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...
Phase 3: June 2008
2JJM
22.6%
Campylobacter jejuni
Cellular processes
Chemotaxis and motility
IDP02306
(
show subtarget assignments
)
1
cloned
No
Cj0079c
15791469
cdtA
cytolethal distending toxin [Campylobact...
268
Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...
Phase 3: June 2008
1SR4
24.3%
Campylobacter jejuni
Cellular processes
Pathogenesis
IDP00211
(
show subtarget assignments
)
1
purified
No
YPO2101
16122340
-
hypothetical phage protein
211
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP02364
(
show subtarget assignments
)
1
cloned
No
Cj0365c
15791732
putative outer membrane channel protein ...
492
Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...
Phase 3: June 2008
3PIK
24.8%
Campylobacter jejuni
Cellular processes
Toxin production and resistance
IDP00026
(
show subtarget assignments
)
1
soluble
No
BA_0399
30253934
tellurium resistance protein, putative
198
Virulence
Phase 1: October 2007
3IBZ
41.9%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00494
(
show subtarget assignments
)
1
soluble
No
YPO0099
16120446
hypothetical protein YPO0099
411
Drug Target Function
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00493
(
show subtarget assignments
)
1
expressed
No
YPO1124
16121424
tolB
translocation protein TolB
430
Conserved Gene / Pathway
Phase 2: March 2008
1C5K
84.9%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP01887
(
show subtarget assignments
)
1
expressed
No
GBAA5729
47531065
spo0J
stage 0 sporulation protein J [Bacillus ...
256
Conserved; Drug target functions
Phase 3: June 2008
1VZ0
36.3%
Bacillus anthracis
Cellular processes
Sporulation and germination
IDP00492
(
show subtarget assignments
)
1
selected
No
YPO1559
16121830
hypothetical protein YPO1559
379
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00209
(
show subtarget assignments
)
1
soluble
No
YPO2062
16122301
-
putative M23/M37 peptidase-family protei...
417
Virulence
Phase 1: October 2007
2GU1
32.4%
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP04552
(
show subtarget assignments
)
1
cloned
No
CPF_2913
110799629
msrA
methionine sulfoxide reductase A [Clostr...
157
conserved gene; putative drug target function;
Phase 4: April 2009
3BQE
52.2%
Clostridium perfringens
Cellular processes
Adaptations to atypical conditions
IDP04093
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1907
218929023
irp5
yersiniabactin siderophore biosynthetic ...
525
drug target; virulence factor; conserved gene; putative drug target function;...
Phase 4: April 2009
1MD9
47.8%
Yersinia pestis
Cellular processes
Cell division
IDP01877
(
show subtarget assignments
)
1
crystallized
No
GBAA0080
47525336
negative regulator of genetic competence...
811
Drug target motif; Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3PXI
80.1%
Bacillus anthracis
Cellular processes
DNA transformation
IDP02620
(
show subtarget assignments
)
1
cloned
No
lmo0205
16802251
plcB
phospholipase C [Listeria monocytogenes ...
289
Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...
Phase 3: June 2008
1AH7
32.5%
Listeria monocytogenes
Cellular processes
Toxin production and resistance
IDP00051
(
show subtarget assignments
)
1
in_pdb
3EDN
Yes
BA_3469
30258008
phenazine biosynthesis protein, PhzF fam...
299
Virulence
Phase 1: October 2007
3EDN
100%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP02831
(
show subtarget assignments
)
1
crystallized
No
GBAA4686
47529986
maf
Maf-like protein [Bacillus anthracis str...
191
Conserved; Drug target functions
Phase 3: June 2008
1EX2
53.4%
Bacillus anthracis
Cellular processes
Cell division
IDP04551
(
show subtarget assignments
)
1
cloned
No
CPF_2912
110800993
maa
maltose transacetylase [Clostridium perf...
195
conserved gene; putative drug target function;
Phase 4: April 2009
1OCX
64.6%
Clostridium perfringens
Cellular processes
Detoxification
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