Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02036 (show subtarget assignments)	1	cloned	No	GBAA1500	47526774		M23/37 family peptidase [Bacillus anthra...	204	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	3SLU	23.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00112 (show subtarget assignments)	1	soluble	No	NT01SF5194	30043810	hflK	protease specific for phage lambda cII r...	419	Essential	Phase 1: October 2007	3BK6	11%	Shigella flexneri	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04153 (show subtarget assignments)	1	cloned	No	YPO3975	218930970	opdA	oligopeptidase A [Yersinia pestis CO92]	680	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1S4B	30.7%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02031 (show subtarget assignments)	1	cloned	No	lmo2504	16804542		hypothetical protein lmo2504 [Listeria m...	436	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2GU1	17.2%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02028 (show subtarget assignments)	1	in_pdb 3Q7H	No	CBU_0738	29541338	clpP	ATP-dependent Clp protease, proteolytic ...	195	Conserved; Drug target functions	Phase 3: June 2008	3Q7H	100%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02639 (show subtarget assignments)	1	soluble	No	FTT0633	56707758	hflK	SPFH domain-containing protein/band 7 fa...	355	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008			Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02021 (show subtarget assignments)	1	cloned	No	CBU_1240	29541810	gcp	O-sialoglycoprotein endopeptidase [Coxie...	339	Conserved; Drug target functions	Phase 3: June 2008	2IVN	36%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02439 (show subtarget assignments)	1	cloned	No	GBAA3892	47529180		serine protease [Bacillus anthracis str....	613	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2OXA	16.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04143 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3275	115348911	clpB	Clp ATPase [Yersinia pestis CO92]	857	drug target; putative drug target function;	Phase 4: April 2009	1QVR	57.1%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00976 (show subtarget assignments)	1	in_crystallization_trials	No	STM1879	16765221	ptrB	protease 2	683	Drug Target Function	Phase 2: March 2008	2XE4	37.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01974 (show subtarget assignments)	1	purified	No	lmo2468	16804506	clpP	ATP-dependent Clp protease proteolytic s...	198	Known virulence-Protease; PMID:11447171; Presence of Protease Motifs	Phase 3: June 2008	3QWD	76.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01962 (show subtarget assignments)	1	in_pdb 3IJ3	Yes	CBU_0572	29541173		cytosol aminopeptidase family protein [C...	458	Conserved; Drug target functions	Phase 3: June 2008	3IJ3	100%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04083 (show subtarget assignments)	1	cloned	No	YPO1631	218928767	pepT	peptidase T [Yersinia pestis CO92]	411	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FNO	76.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02427 (show subtarget assignments)	1	purified	No	GBAA3553	47528837	pepF-2	oligoendopeptidase F [Bacillus anthracis...	595	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QR4	37.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00504 (show subtarget assignments)	1	expressed	No	YPO1015	16121316		hypothetical protein YPO1015	202	Drug Target Function	Phase 2: March 2008			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01931 (show subtarget assignments)	1	soluble	No	CBU_0073	29540696		peptidase, M24 family protein [Coxiella ...	597	Conserved; Drug target functions	Phase 3: June 2008	3CTZ	40.6%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02442 (show subtarget assignments)	1	soluble	No	GBAA4092	47778244		prophage LambdaBa02, Clp protease family...	251	Drug target motif; Drug target functions	Phase 3: June 2008	2F6I	21.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02558 (show subtarget assignments)	1	cloned	No	GBAA4584	47529880	vpR	minor extracellular protease VpR [Bacill...	917	Drug target motif; Drug target functions	Phase 3: June 2008	3EIF	22.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01919 (show subtarget assignments)	1	in_crystallization_trials	No	STM3349	16766644	degS	serine endoprotease [Salmonella typhimur...	356	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3GCN	84.3%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01889 (show subtarget assignments)	1	soluble	No	STM0209	16763599	htrA	serine endoprotease [Salmonella typhimur...	475	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2ZLE	87.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02531 (show subtarget assignments)	1	in_pdb 3LAC	Yes	GBAA3090	50196941	pcP	pyrrolidone-carboxylate peptidase [Bacil...	215	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3LAC	99.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01872 (show subtarget assignments)	1	cloned	No	GBAA5706	47531042		oligoendopeptidase F, putative [Bacillus...	605	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QR4	29.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01870 (show subtarget assignments)	1	cloned	No	GBAA5710	47531047		serine protease [Bacillus anthracis str....	391	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GCN	31.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02506 (show subtarget assignments)	1	soluble	No	FTT0609	56707734		peptidase, M24 family protein [Francisel...	597	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3CTZ	37.4%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02574 (show subtarget assignments)	1	cloned	No	GBAA1995	47527292		protease, putative [Bacillus anthracis s...	386	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01851 (show subtarget assignments)	1	cloned	No	GBAA5427	47778402		endopeptidase lytE, putative [Bacillus a...	436	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3H41	9.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04152 (show subtarget assignments)	1	cloned	No	YPO3919	218930919		HlyD family secretion protein [Yersinia ...	442	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02830 (show subtarget assignments)	1	soluble	No	GBAA4861	47530155	pepQ-2	proline dipeptidase [Bacillus anthracis ...	365	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WY2	38.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01804 (show subtarget assignments)	1	cloned	No	GBAA5414	47530727		carboxyl-terminal protease [Bacillus ant...	469	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FC6	19.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02283 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0062	16802110		hypothetical protein lmo0062 [Listeria m...	131	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008			Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01772 (show subtarget assignments)	1	cloned	No	YPO3599	16123741	clpB2	Clp ATPase [Yersinia pestis CO92]	867	Drug target motif; CD; Drug target functions	Phase 3: June 2008	1QVR	33.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01761 (show subtarget assignments)	1	cloned	No	GBAA5606	47530928		aminopeptidase, putative [Bacillus anthr...	466	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2EK8	33%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01752 (show subtarget assignments)	1	selected	No	GBAA5282	47778383	nprB	neutral protease B [Bacillus anthracis s...	547	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1KEI	31.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02563 (show subtarget assignments)	1	cloned	No	GBAA3299	47528584		collagenase, putative [Bacillus anthraci...	960	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00455 (show subtarget assignments)	1	purified	No	YPO3080	16123257	tesA	multifunctional acyl-CoA thioesterase I ...	212	Conserved Gene / Pathway	Phase 2: March 2008	1IVN	60.4%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02404 (show subtarget assignments)	1	cloned	No	GBAA2730	47528021		neutral protease [Bacillus anthracis str...	567	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	25.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01711 (show subtarget assignments)	1	expressed	No	GBAA5380	47530690	clpP	ATP-dependent Clp protease proteolytic s...	193	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TT7	89.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00448 (show subtarget assignments)	1	purified	No	YPO0646	16120971	gcp	O-sialoglycoprotein endopeptidase	337	Drug Target Function	Phase 2: March 2008	2IVN	35.6%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02538 (show subtarget assignments)	1	soluble	No	FTT1746	56708744		peptidase [Francisella tularensis subsp....	307	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3RST	23.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00838 (show subtarget assignments)	1	purified	No	SACOL0833	57284295	clpP	ATP-dependent Clp protease, proteolytic ...	195	Drug Target Function	Phase 2: March 2008	3QWD	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01702 (show subtarget assignments)	1	soluble	No	GBAA0261	47525520	gcP	O-sialoglycoprotein endopeptidase [Bacil...	338	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IVN	35.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00836 (show subtarget assignments)	1	in_pdb 3GIU	No	SACOL2714	57285268	pcp	pyrrolidone-carboxylate peptidase	212	Drug Target Function	Phase 2: March 2008	3GIU	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02398 (show subtarget assignments)	1	in_pdb 3PEI	Yes	FTT1318c	56708375	pepA	cytosol aminopeptidase [Francisella tula...	479	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3PEI	100%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01673 (show subtarget assignments)	1	purified	No	GBAA5206	47530513		M23/37 family peptidase [Bacillus anthra...	327	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	3SLU	25.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01666 (show subtarget assignments)	1	purified	No	GBAA4704	47530003	clpX	ATP-dependent protease ATP-binding subun...	419	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HTE	52.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01661 (show subtarget assignments)	1	soluble	No	GBAA4609	47529906		U32 family peptidase [Bacillus anthracis...	426	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02331 (show subtarget assignments)	1	selected	No	GBAA2661	47527952	adP-1	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	30.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04359 (show subtarget assignments)	1	cloned	No	YPO1414	218928562	pepN	aminopeptidase N [Yersinia pestis CO92]	871	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	77.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00809 (show subtarget assignments)	1	cloned	No	SACOL1869	57284790	splA	serine protease SplA	238	Drug Target Function	Phase 2: March 2008	2W7S	84%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01651 (show subtarget assignments)	1	cloned	No	YPO2946	16123129	clpB5	Clp ATPase [Yersinia pestis CO92]	891	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	1QVR	35.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00808 (show subtarget assignments)	1	cloned	No	SACOL1868	57284789	splB	serine protease SplB	240	Drug Target Function	Phase 2: March 2008	2VID	85%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00805 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1801	57286235		dipeptidase PepV	469	Drug Target Function	Phase 2: March 2008	3KHX	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01644 (show subtarget assignments)	1	cloned	No	FTT0626	56707751	lon	DNA-binding, ATP-dependent protease La [...	774	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3M6A	37.7%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00800 (show subtarget assignments)	1	purified	No	SACOL1419	57286070		oligoendopeptidase F, putative	604	Drug Target Function	Phase 2: March 2008	2QR4	23.8%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02821 (show subtarget assignments)	1	in_pdb 3P2L	No	FTT0624	56707749	clpP	ATP-dependent Clp protease subunit P [Fr...	201	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3P2L	98.5%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02566 (show subtarget assignments)	1	purified	No	GBAA3033	50196939	adP-2	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	31.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00423 (show subtarget assignments)	1	soluble	No	YPO1019	16121320	ptrA	protease III precursor	962	Drug Target Function	Phase 2: March 2008	1Q2L	61.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00084 (show subtarget assignments)	1	expressed	No	NT01ST1435	16419673	yceI	putative secreted protein	191	Essential	Phase 1: October 2007	1Y0G	91.1%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00418 (show subtarget assignments)	1	crystallized	No	YPO0910	16121215	pepP	proline aminopeptidase P II	437	Drug Target Function	Phase 2: March 2008	1A16	81.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01496 (show subtarget assignments)	1	soluble	No	VCA0813	15601568		aminopeptidase	501	Drug Target Function	Phase 2: March 2008	1RTQ	43.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01495 (show subtarget assignments)	1	cloned	No	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02272 (show subtarget assignments)	1	cloned	No	GBAA2183	47527475		neutral metalloprotease, putative [Bacil...	503	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	1BQB	14.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01483 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0180	15600950		peptidase T	410	Drug Target Function	Phase 2: March 2008	1VIX	57.6%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02701 (show subtarget assignments)	1	soluble	No	FTT1322	56708379		peptidase M16 family protein [Francisell...	407	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3GWB	29%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01480 (show subtarget assignments)	1	cloned	No	VCA0116	15600887		clpB protein	869	Drug Target Function	Phase 2: March 2008	1QVR	36.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01475 (show subtarget assignments)	1	in_crystallization_trials	No	VC2675	15642670		ATP-dependent protease peptidase subunit...	185	Conserved Gene / Pathway	Phase 2: March 2008	1E94	78.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02816 (show subtarget assignments)	1	soluble	No	GBAA4014	47529307		proline dipeptidase, putative [Bacillus ...	356	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3Q6D	56.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02747 (show subtarget assignments)	1	soluble	No	FTT0147	56707317	gcp	O-sialoglycoprotein endopeptidase [Franc...	336	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2IVN	35.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02413 (show subtarget assignments)	1	cloned	No	YPO3568	16123712	degS	serine endoprotease [Yersinia pestis CO9...	362	Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...	Phase 3: June 2008	1SOT	63%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01437 (show subtarget assignments)	1	purified	No	VC1983	15641985		peptidase, putative	615	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01433 (show subtarget assignments)	1	purified	No	VC1922	15641924	clpP	ATP-dependent Clp protease proteolytic s...	200	Drug Target Function	Phase 2: March 2008	1TYF	76%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01428 (show subtarget assignments)	1	purified	No	VC1709	15641713		zinc protease, insulinase family	922	Drug Target Function	Phase 2: March 2008	3CWW	19%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00723 (show subtarget assignments)	1	cloned	No	SACOL1668	57284681		peptidase, U32 family	307	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00722 (show subtarget assignments)	1	purified	No	SACOL1667	57284680		peptidase, U32 family	422	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01420 (show subtarget assignments)	1	cloned	No	VC1496	15641505		carboxy-terminal protease	665	Drug Target Function	Phase 2: March 2008	1FC6	16.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01417 (show subtarget assignments)	1	soluble	No	VC1414	15641425		thermostable carboxypeptidase 1	524	Drug Target Function	Phase 2: March 2008	3DWC	44.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01397 (show subtarget assignments)	1	purified	No	VC0755	161582019		aminopeptidase B	429	Drug Target Function	Phase 2: March 2008	3H8E	32.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04491 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3765	218930769	pepQ	proline dipeptidase [Yersinia pestis CO9...	443	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RVA	54.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02710 (show subtarget assignments)	1	in_pdb 3LU2	No	lmo2462	16804500		hypothetical protein lmo2462 [Listeria m...	308	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3LU2	100%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01387 (show subtarget assignments)	1	cloned	No	VC0566	15640588		protease DO	456	Drug Target Function	Phase 2: March 2008	2ZLE	57.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01386 (show subtarget assignments)	1	soluble	No	VC0565	15640587		protease DegS	352	Drug Target Function	Phase 2: March 2008	1SOT	47.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01384 (show subtarget assignments)	1	purified	No	VC0554	15640576		protease, insulinase family/protease, in...	952	Drug Target Function	Phase 2: March 2008	1Q2L	19.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02657 (show subtarget assignments)	1	cloned	No	lmo0203	16802249	mpl	Zinc metalloproteinase precursor [Lister...	510	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...	Phase 3: June 2008	1BQB	27.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00697 (show subtarget assignments)	1	purified	No	SACOL2563	57285245		ATP-dependent Clp protease, putative	701	Drug Target Function	Phase 2: March 2008	1QVR	43.1%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01373 (show subtarget assignments)	1	soluble	No	VC0335	15640362		NlpD-related protein	382	Drug Target Function	Phase 2: March 2008	3SLU	13.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00695 (show subtarget assignments)	1	purified	No	SACOL2322	57285057		peptidase, M20/M25/M40 family	373	Drug Target Function	Phase 2: March 2008	1YSJ	41.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01361 (show subtarget assignments)	1	expressed	No	VC0157	15640187		alkaline serine protease	535	Drug Target Function	Phase 2: March 2008	1S2N	35.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00687 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2038	57284907		O-sialoglycoprotein endopeptidase	341	Drug Target Function	Phase 2: March 2008	2IVN	30.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00683 (show subtarget assignments)	1	purified	No	SACOL1795	57286229	pepA1	glutamyl aminopeptidase	358	Drug Target Function	Phase 2: March 2008	3KL9	38.8%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00682 (show subtarget assignments)	1	cloned	No	SACOL1777	57286212		serine protease HtrA, putative	424	Drug Target Function	Phase 2: March 2008	2ZLE	29%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00681 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1756	57286191	pepQ	proline dipeptidase	351	Drug Target Function	Phase 2: March 2008	1WY2	41.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00680 (show subtarget assignments)	1	purified	No	SACOL1721	57284732	clpX	ATP-dependent protease ATP-binding subun...	420	Drug Target Function	Phase 2: March 2008	3HWS	52.4%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00677 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1588	57286110		proline dipeptidase	353	Drug Target Function	Phase 2: March 2008	3Q6D	49.4%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01335 (show subtarget assignments)	1	soluble	No	VC1144	15641157	clpA	ATP-dependent Clp protease ATP-binding s...	756	Drug Target Function	Phase 2: March 2008	1KSF	77.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00675 (show subtarget assignments)	1	cloned	No	SACOL1455	57284564		carboxyl-terminal protease	496	Drug Target Function	Phase 2: March 2008	1FC6	20%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02793 (show subtarget assignments)	1	cloned	No	GBAA4702	47530001	loN	ATP-dependent protease La 1 [Bacillus an...	773	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3M6A	53.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04443 (show subtarget assignments)	1	cloned	No	YPO0506	218927704	clpB	putative Clp ATPase [Yersinia pestis CO9...	867	virulence factor; putative drug target function;	Phase 4: April 2009	1QVR	36.3%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00664 (show subtarget assignments)	1	cloned	No	SACOL1028	57284400	htrA	serine protease	769	Drug Target Function	Phase 2: March 2008	2ZLE	12.7%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00663 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0979	57285852	clpB	ATP-dependent Clp protease, ATP-binding ...	869	Drug Target Function	Phase 2: March 2008	1QVR	54.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00662 (show subtarget assignments)	1	in_pdb 3KZW	No	SACOL0945	57285819		cytosol aminopeptidase	491	Drug Target Function	Phase 2: March 2008	3KZW	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02036
(show subtarget assignments)

1

cloned

No

GBAA1500

47526774

M23/37 family peptidase [Bacillus anthra...

204

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

3SLU

23.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00112
(show subtarget assignments)

1

soluble

No

NT01SF5194

30043810

hflK

protease specific for phage lambda cII r...

419

Essential

Phase 1: October 2007

3BK6

11%

Shigella flexneri

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04153
(show subtarget assignments)

1

cloned

No

YPO3975

218930970

opdA

oligopeptidase A [Yersinia pestis CO92]

680

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1S4B

30.7%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02031
(show subtarget assignments)

1

cloned

No

lmo2504

16804542

hypothetical protein lmo2504 [Listeria m...

436

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2GU1

17.2%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02028
(show subtarget assignments)

1

in_pdb
3Q7H

No

CBU_0738

29541338

clpP

ATP-dependent Clp protease, proteolytic ...

195

Conserved; Drug target functions

Phase 3: June 2008

3Q7H

100%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02639
(show subtarget assignments)

1

soluble

No

FTT0633

56707758

hflK

SPFH domain-containing protein/band 7 fa...

355

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02021
(show subtarget assignments)

1

cloned

No

CBU_1240

29541810

gcp

O-sialoglycoprotein endopeptidase [Coxie...

339

Conserved; Drug target functions

Phase 3: June 2008

2IVN

36%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02439
(show subtarget assignments)

1

cloned

No

GBAA3892

47529180

serine protease [Bacillus anthracis str....

613

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2OXA

16.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04143
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3275

115348911

clpB

Clp ATPase [Yersinia pestis CO92]

857

drug target; putative drug target function;

Phase 4: April 2009

1QVR

57.1%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00976
(show subtarget assignments)

1

in_crystallization_trials

No

STM1879

16765221

ptrB

protease 2

683

Drug Target Function

Phase 2: March 2008

2XE4

37.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01974
(show subtarget assignments)

1

purified

No

lmo2468

16804506

clpP

ATP-dependent Clp protease proteolytic s...

198

Known virulence-Protease; PMID:11447171; Presence of Protease Motifs

Phase 3: June 2008

3QWD

76.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01962
(show subtarget assignments)

1

in_pdb
3IJ3

Yes

CBU_0572

29541173

cytosol aminopeptidase family protein [C...

458

Conserved; Drug target functions

Phase 3: June 2008

3IJ3

100%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04083
(show subtarget assignments)

1

cloned

No

YPO1631

218928767

pepT

peptidase T [Yersinia pestis CO92]

411

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FNO

76.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02427
(show subtarget assignments)

1

purified

No

GBAA3553

47528837

pepF-2

oligoendopeptidase F [Bacillus anthracis...

595

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QR4

37.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00504
(show subtarget assignments)

1

expressed

No

YPO1015

16121316

hypothetical protein YPO1015

202

Drug Target Function

Phase 2: March 2008

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01931
(show subtarget assignments)

1

soluble

No

CBU_0073

29540696

peptidase, M24 family protein [Coxiella ...

597

Conserved; Drug target functions

Phase 3: June 2008

3CTZ

40.6%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02442
(show subtarget assignments)

1

soluble

No

GBAA4092

47778244

prophage LambdaBa02, Clp protease family...

251

Drug target motif; Drug target functions

Phase 3: June 2008

2F6I

21.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02558
(show subtarget assignments)

1

cloned

No

GBAA4584

47529880

vpR

minor extracellular protease VpR [Bacill...

917

Drug target motif; Drug target functions

Phase 3: June 2008

3EIF

22.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01919
(show subtarget assignments)

1

in_crystallization_trials

No

STM3349

16766644

degS

serine endoprotease [Salmonella typhimur...

356

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3GCN

84.3%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01889
(show subtarget assignments)

1

soluble

No

STM0209

16763599

htrA

serine endoprotease [Salmonella typhimur...

475

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2ZLE

87.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02531
(show subtarget assignments)

1

in_pdb
3LAC

Yes

GBAA3090

50196941

pcP

pyrrolidone-carboxylate peptidase [Bacil...

215

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3LAC

99.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01872
(show subtarget assignments)

1

cloned

No

GBAA5706

47531042

oligoendopeptidase F, putative [Bacillus...

605

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QR4

29.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01870
(show subtarget assignments)

1

cloned

No

GBAA5710

47531047

serine protease [Bacillus anthracis str....

391

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GCN

31.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02506
(show subtarget assignments)

1

soluble

No

FTT0609

56707734

peptidase, M24 family protein [Francisel...

597

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3CTZ

37.4%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02574
(show subtarget assignments)

1

cloned

No

GBAA1995

47527292

protease, putative [Bacillus anthracis s...

386

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01851
(show subtarget assignments)

1

cloned

No

GBAA5427

47778402

endopeptidase lytE, putative [Bacillus a...

436

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3H41

9.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04152
(show subtarget assignments)

1

cloned

No

YPO3919

218930919

HlyD family secretion protein [Yersinia ...

442

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02830
(show subtarget assignments)

1

soluble

No

GBAA4861

47530155

pepQ-2

proline dipeptidase [Bacillus anthracis ...

365

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WY2

38.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01804
(show subtarget assignments)

1

cloned

No

GBAA5414

47530727

carboxyl-terminal protease [Bacillus ant...

469

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FC6

19.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02283
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0062

16802110

hypothetical protein lmo0062 [Listeria m...

131

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01772
(show subtarget assignments)

1

cloned

No

YPO3599

16123741

clpB2

Clp ATPase [Yersinia pestis CO92]

867

Drug target motif; CD; Drug target functions

Phase 3: June 2008

1QVR

33.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01761
(show subtarget assignments)

1

cloned

No

GBAA5606

47530928

aminopeptidase, putative [Bacillus anthr...

466

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2EK8

33%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01752
(show subtarget assignments)

1

selected

No

GBAA5282

47778383

nprB

neutral protease B [Bacillus anthracis s...

547

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1KEI

31.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02563
(show subtarget assignments)

1

cloned

No

GBAA3299

47528584

collagenase, putative [Bacillus anthraci...

960

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00455
(show subtarget assignments)

1

purified

No

YPO3080

16123257

tesA

multifunctional acyl-CoA thioesterase I ...

212

Conserved Gene / Pathway

Phase 2: March 2008

1IVN

60.4%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02404
(show subtarget assignments)

1

cloned

No

GBAA2730

47528021

neutral protease [Bacillus anthracis str...

567

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

25.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01711
(show subtarget assignments)

1

expressed

No

GBAA5380

47530690

clpP

ATP-dependent Clp protease proteolytic s...

193

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TT7

89.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00448
(show subtarget assignments)

1

purified

No

YPO0646

16120971

gcp

O-sialoglycoprotein endopeptidase

337

Drug Target Function

Phase 2: March 2008

2IVN

35.6%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02538
(show subtarget assignments)

1

soluble

No

FTT1746

56708744

peptidase [Francisella tularensis subsp....

307

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3RST

23.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00838
(show subtarget assignments)

1

purified

No

SACOL0833

57284295

clpP

ATP-dependent Clp protease, proteolytic ...

195

Drug Target Function

Phase 2: March 2008

3QWD

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01702
(show subtarget assignments)

1

soluble

No

GBAA0261

47525520

gcP

O-sialoglycoprotein endopeptidase [Bacil...

338

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IVN

35.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00836
(show subtarget assignments)

1

in_pdb
3GIU

No

SACOL2714

57285268

pcp

pyrrolidone-carboxylate peptidase

212

Drug Target Function

Phase 2: March 2008

3GIU

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02398
(show subtarget assignments)

1

in_pdb
3PEI

Yes

FTT1318c

56708375

pepA

cytosol aminopeptidase [Francisella tula...

479

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3PEI

100%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01673
(show subtarget assignments)

1

purified

No

GBAA5206

47530513

M23/37 family peptidase [Bacillus anthra...

327

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

3SLU

25.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01666
(show subtarget assignments)

1

purified

No

GBAA4704

47530003

clpX

ATP-dependent protease ATP-binding subun...

419

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HTE

52.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01661
(show subtarget assignments)

1

soluble

No

GBAA4609

47529906

U32 family peptidase [Bacillus anthracis...

426

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02331
(show subtarget assignments)

1

selected

No

GBAA2661

47527952

adP-1

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

30.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04359
(show subtarget assignments)

1

cloned

No

YPO1414

218928562

pepN

aminopeptidase N [Yersinia pestis CO92]

871

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

77.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00809
(show subtarget assignments)

1

cloned

No

SACOL1869

57284790

splA

serine protease SplA

238

Drug Target Function

Phase 2: March 2008

2W7S

84%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01651
(show subtarget assignments)

1

cloned

No

YPO2946

16123129

clpB5

Clp ATPase [Yersinia pestis CO92]

891

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

1QVR

35.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00808
(show subtarget assignments)

1

cloned

No

SACOL1868

57284789

splB

serine protease SplB

240

Drug Target Function

Phase 2: March 2008

2VID

85%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00805
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1801

57286235

dipeptidase PepV

469

Drug Target Function

Phase 2: March 2008

3KHX

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01644
(show subtarget assignments)

1

cloned

No

FTT0626

56707751

lon

DNA-binding, ATP-dependent protease La [...

774

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3M6A

37.7%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00800
(show subtarget assignments)

1

purified

No

SACOL1419

57286070

oligoendopeptidase F, putative

604

Drug Target Function

Phase 2: March 2008

2QR4

23.8%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02821
(show subtarget assignments)

1

in_pdb
3P2L

No

FTT0624

56707749

clpP

ATP-dependent Clp protease subunit P [Fr...

201

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3P2L

98.5%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02566
(show subtarget assignments)

1

purified

No

GBAA3033

50196939

adP-2

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

31.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00423
(show subtarget assignments)

1

soluble

No

YPO1019

16121320

ptrA

protease III precursor

962

Drug Target Function

Phase 2: March 2008

1Q2L

61.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00084
(show subtarget assignments)

1

expressed

No

NT01ST1435

16419673

yceI

putative secreted protein

191

Essential

Phase 1: October 2007

1Y0G

91.1%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00418
(show subtarget assignments)

1

crystallized

No

YPO0910

16121215

pepP

proline aminopeptidase P II

437

Drug Target Function

Phase 2: March 2008

1A16

81.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01496
(show subtarget assignments)

1

soluble

No

VCA0813

15601568

aminopeptidase

501

Drug Target Function

Phase 2: March 2008

1RTQ

43.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01495
(show subtarget assignments)

1

cloned

No

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02272
(show subtarget assignments)

1

cloned

No

GBAA2183

47527475

neutral metalloprotease, putative [Bacil...

503

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

1BQB

14.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01483
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0180

15600950

peptidase T

410

Drug Target Function

Phase 2: March 2008

1VIX

57.6%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02701
(show subtarget assignments)

1

soluble

No

FTT1322

56708379

peptidase M16 family protein [Francisell...

407

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3GWB

29%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01480
(show subtarget assignments)

1

cloned

No

VCA0116

15600887

clpB protein

869

Drug Target Function

Phase 2: March 2008

1QVR

36.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01475
(show subtarget assignments)

1

in_crystallization_trials

No

VC2675

15642670

ATP-dependent protease peptidase subunit...

185

Conserved Gene / Pathway

Phase 2: March 2008

1E94

78.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02816
(show subtarget assignments)

1

soluble

No

GBAA4014

47529307

proline dipeptidase, putative [Bacillus ...

356

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3Q6D

56.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02747
(show subtarget assignments)

1

soluble

No

FTT0147

56707317

gcp

O-sialoglycoprotein endopeptidase [Franc...

336

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2IVN

35.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02413
(show subtarget assignments)

1

cloned

No

YPO3568

16123712

degS

serine endoprotease [Yersinia pestis CO9...

362

Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...

Phase 3: June 2008

1SOT

63%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01437
(show subtarget assignments)

1

purified

No

VC1983

15641985

peptidase, putative

615

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01433
(show subtarget assignments)

1

purified

No

VC1922

15641924

clpP

ATP-dependent Clp protease proteolytic s...

200

Drug Target Function

Phase 2: March 2008

1TYF

76%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01428
(show subtarget assignments)

1

purified

No

VC1709

15641713

zinc protease, insulinase family

922

Drug Target Function

Phase 2: March 2008

3CWW

19%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00723
(show subtarget assignments)

1

cloned

No

SACOL1668

57284681

peptidase, U32 family

307

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00722
(show subtarget assignments)

1

purified

No

SACOL1667

57284680

peptidase, U32 family

422

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01420
(show subtarget assignments)

1

cloned

No

VC1496

15641505

carboxy-terminal protease

665

Drug Target Function

Phase 2: March 2008

1FC6

16.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01417
(show subtarget assignments)

1

soluble

No

VC1414

15641425

thermostable carboxypeptidase 1

524

Drug Target Function

Phase 2: March 2008

3DWC

44.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01397
(show subtarget assignments)

1

purified

No

VC0755

161582019

aminopeptidase B

429

Drug Target Function

Phase 2: March 2008

3H8E

32.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04491
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3765

218930769

pepQ

proline dipeptidase [Yersinia pestis CO9...

443

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RVA

54.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02710
(show subtarget assignments)

1

in_pdb
3LU2

No

lmo2462

16804500

hypothetical protein lmo2462 [Listeria m...

308

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3LU2

100%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01387
(show subtarget assignments)

1

cloned

No

VC0566

15640588

protease DO

456

Drug Target Function

Phase 2: March 2008

2ZLE

57.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01386
(show subtarget assignments)

1

soluble

No

VC0565

15640587

protease DegS

352

Drug Target Function

Phase 2: March 2008

1SOT

47.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01384
(show subtarget assignments)

1

purified

No

VC0554

15640576

protease, insulinase family/protease, in...

952

Drug Target Function

Phase 2: March 2008

1Q2L

19.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02657
(show subtarget assignments)

1

cloned

No

lmo0203

16802249

mpl

Zinc metalloproteinase precursor [Lister...

510

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...

Phase 3: June 2008

1BQB

27.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00697
(show subtarget assignments)

1

purified

No

SACOL2563

57285245

ATP-dependent Clp protease, putative

701

Drug Target Function

Phase 2: March 2008

1QVR

43.1%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01373
(show subtarget assignments)

1

soluble

No

VC0335

15640362

NlpD-related protein

382

Drug Target Function

Phase 2: March 2008

3SLU

13.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00695
(show subtarget assignments)

1

purified

No

SACOL2322

57285057

peptidase, M20/M25/M40 family

373

Drug Target Function

Phase 2: March 2008

1YSJ

41.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01361
(show subtarget assignments)

1

expressed

No

VC0157

15640187

alkaline serine protease

535

Drug Target Function

Phase 2: March 2008

1S2N

35.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00687
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2038

57284907

O-sialoglycoprotein endopeptidase

341

Drug Target Function

Phase 2: March 2008

2IVN

30.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00683
(show subtarget assignments)

1

purified

No

SACOL1795

57286229

pepA1

glutamyl aminopeptidase

358

Drug Target Function

Phase 2: March 2008

3KL9

38.8%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00682
(show subtarget assignments)

1

cloned

No

SACOL1777

57286212

serine protease HtrA, putative

424

Drug Target Function

Phase 2: March 2008

2ZLE

29%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00681
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1756

57286191

pepQ

proline dipeptidase

351

Drug Target Function

Phase 2: March 2008

1WY2

41.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00680
(show subtarget assignments)

1

purified

No

SACOL1721

57284732

clpX

ATP-dependent protease ATP-binding subun...

420

Drug Target Function

Phase 2: March 2008

3HWS

52.4%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00677
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1588

57286110

proline dipeptidase

353

Drug Target Function

Phase 2: March 2008

3Q6D

49.4%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01335
(show subtarget assignments)

1

soluble

No

VC1144

15641157

clpA

ATP-dependent Clp protease ATP-binding s...

756

Drug Target Function

Phase 2: March 2008

1KSF

77.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00675
(show subtarget assignments)

1

cloned

No

SACOL1455

57284564

carboxyl-terminal protease

496

Drug Target Function

Phase 2: March 2008

1FC6

20%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02793
(show subtarget assignments)

1

cloned

No

GBAA4702

47530001

loN

ATP-dependent protease La 1 [Bacillus an...

773

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3M6A

53.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04443
(show subtarget assignments)

1

cloned

No

YPO0506

218927704

clpB

putative Clp ATPase [Yersinia pestis CO9...

867

virulence factor; putative drug target function;

Phase 4: April 2009

1QVR

36.3%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00664
(show subtarget assignments)

1

cloned

No

SACOL1028

57284400

htrA

serine protease

769

Drug Target Function

Phase 2: March 2008

2ZLE

12.7%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00663
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0979

57285852

clpB

ATP-dependent Clp protease, ATP-binding ...

869

Drug Target Function

Phase 2: March 2008

1QVR

54.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00662
(show subtarget assignments)

1

in_pdb
3KZW

No

SACOL0945

57285819

cytosol aminopeptidase

491

Drug Target Function

Phase 2: March 2008

3KZW

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

Targets