Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02805 (show subtarget assignments)	1	expressed	No	Cj1129c	15792454	wlaC	general glycosylation pathway protein [C...	359	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	3L01	26.5%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01720 (show subtarget assignments)	1	cloned	No	Cj1128c	15792453	wlaD	general glycosylation pathway protein [C...	309	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	3BCV	16.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02634 (show subtarget assignments)	1	cloned	No	Cj1125c	15792450	wlaG	general glycosylation pathway protein [C...	376	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	2JJM	22.6%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP04716 (show subtarget assignments)	1	cloned	No	YPO0817	218927996		general secretion pathway protein C [Yer...	167	putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04449 (show subtarget assignments)	1	cloned	No	YPO0816	218927995		general secretion pathway protein D [Yer...	640	putative drug target function;	Phase 4: April 2009	3EZJ	15.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02238 (show subtarget assignments)	1	expressed	No	YPO0815	16121126		general secretion pathway protein E [Yer...	503	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	48.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04715 (show subtarget assignments)	1	expressed	No	YPO0813	115346604		general secretion pathway protein G [Yer...	145	drug target; putative drug target function;	Phase 4: April 2009	3G20	51%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04292 (show subtarget assignments)	1	cloned	No	YPO0812	218927992		general secretion pathway protein H [Yer...	180	conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04138 (show subtarget assignments)	1	expressed	No	YPO0811	218927991		general secretion pathway protein I [Yer...	114	putative drug target function;	Phase 4: April 2009	3CI0	19.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04448 (show subtarget assignments)	1	cloned	No	YPO0810	218927990		general secretion pathway protein J [Yer...	198	putative drug target function;	Phase 4: April 2009	2RET	20.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04285 (show subtarget assignments)	1	expressed	No	YPO0809	218927989		general secretion pathway protein K [Yer...	318	putative drug target function;	Phase 4: April 2009	3CI0	18.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04284 (show subtarget assignments)	1	cloned	No	YPO0808	218927988		general secretion pathway protein L [Yer...	389	putative drug target function;	Phase 4: April 2009	1W97	13.1%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP01255 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5132	30259616	yugI	general stress protein 13	114	Conserved Gene / Pathway	Phase 2: March 2008	2K4K	53.3%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01540 (show subtarget assignments)	1	in_pdb 3EC6	No	GBAA0418	47525694		general stress protein 26 [Bacillus anth...	138	CONSERVED	Phase 3: June 2008	3EC6	100%	Bacillus anthracis

IDP91951 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100010278	298255964		general stress protein GSP-781 [Streptoc...	392	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2K3A	9.4%	Streptococcus pneumoniae

IDP91796 (show subtarget assignments)	8	in_crystallization_trials	No	AAB49832	1854639		gentamicin resistance protein [Enterococ...	306	other biological interest / Kinase	Community Requests	3TDV	100%	Enterococcus gallinarum

IDP05732 (show subtarget assignments)	1	cloned	No	CD1205	126698801	ispA	geranyltranstransferase [Clostridium dif...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J1P	45.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP02624 (show subtarget assignments)	1	soluble	No	FTT1562	56708589	ispA	geranyltranstransferase [Francisella tul...	293	Conserved; Drug target functions	Phase 3: June 2008	2FOR	40.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02030 (show subtarget assignments)	1	expressed	No	CBU_1255	29541825		geranyltranstransferase, putative [Coxie...	267	Conserved; Drug target functions	Phase 3: June 2008	3TS7	40.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90890 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3176	16123338	ispA	geranyltranstransferase [Yersinia pestis...	306	Predicted Essential	Community Requests	2FOR	70.9%	Yersinia pestis

IDP04203 (show subtarget assignments)	1	selected	No	CPF_2298	110800865	gpr	germination protease [Clostridium perfri...	325	conserved gene; putative drug target function;	Phase 4: April 2009	1C8B	42.3%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4546	33301122		Germination protease precursor (Spore pr...	368	Drug Target Function	Phase 2: March 2008	1C8B	70.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05489 (show subtarget assignments)	1	soluble	No	CD0106	126697677	cwlD	germination-specific N-acetylmuramoyl-L-...	250	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JWQ	25.6%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP91424 (show subtarget assignments)	8	expressed	No	VV1_0551	27364013		GGDEF domain-containing protein [Vibrio ...	591	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3BRE	14%	Vibrio vulnificus

IDP90962 (show subtarget assignments)	8	purified	No	VC2750	81544306		GGDEF family protein	849	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	2R6O	13%	Vibrio cholerae

IDP90961 (show subtarget assignments)	8	purified	No	VP0117	81728759		GGDEF family protein	848	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	12.3%	Vibrio parahaemolyticus

IDP02350 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2977	16123158	glk	glucokinase [Yersinia pestis CO92]	323	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1Q18	78.6%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00829 (show subtarget assignments)	1	purified	No	SACOL2515	57285199	gntK	gluconokinase	517	Drug Target Function	Phase 2: March 2008	3GBT	39.3%	Staphylococcus aureus	Energy metabolism	Sugars

IDP01344 (show subtarget assignments)	1	crystallized	No	VCA1025	15601778	nagB	glucosamine-6-phosphate deaminase	266	Drug Target Function	Phase 2: March 2008	1CD5	79.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP00340 (show subtarget assignments)	1	in_pdb 3TBF	No	FTT0388	56707537	glmS	Glucosamine--fructose-6-phosphate aminot...	612	Drug Target Function	Phase 2: March 2008	3TBF	60.8%	Francisella tularensis	Central intermediary metabolism	Amino sugars

IDP05186 (show subtarget assignments)	1	cloned	No	CD0120	126697692	glmS	glucosamine--fructose-6-phosphate aminot...	610	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JXA	47.1%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP01927 (show subtarget assignments)	1	expressed	No	CBU_1787	29542344	glmS	glucosamine--fructose-6-phosphate aminot...	611	Conserved; Drug target functions	Phase 3: June 2008	1JXA	58.3%	Coxiella burnetii	Central intermediary metabolism	Amino sugars

IDP01606 (show subtarget assignments)	1	cloned	No	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP00110 (show subtarget assignments)	1	purified	No	NT01SF4145	30043548	glgC	glucose-1-phosphate adenylyltransferase ...	431	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3BRK	55.2%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04623 (show subtarget assignments)	1	expressed	No	BAS4760	49187751		glucose-1-phosphate adenylyltransferase ...	376	Proposed to be essential proteins	Phase 4: April 2009	3BRK	40%	Bacillus anthracis

IDP01254 (show subtarget assignments)	1	in_pdb 4ECM 3HL3	Yes	BA_1228	30255177		glucose-1-phosphate thymidylyltransferas...	245	Conserved Gene / Pathway	Phase 2: March 2008	3HL3	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90675 (show subtarget assignments)	8	cloned	No	YPO3861	16123996	rffH	glucose-1-phosphate thymidylyltransferas...	293	Predicted Essential	Community Requests	1MC3	86.7%	Yersinia pestis

IDP92016 (show subtarget assignments)	8	selected	No	TGME49_078830	237842577		glucose-6-phosphate dehydrogenase, putat...	878	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BH9	27.8%	Toxoplasma gondii

IDP00736 (show subtarget assignments)	1	in_pdb 3FF1	No	SACOL0966	57285840	pgi	glucose-6-phosphate isomerase	443	Drug Target Function	Phase 2: March 2008	3FF1	100%	Staphylococcus aureus	Energy metabolism	Glycolysis/gluconeogenesis

IDP01329 (show subtarget assignments)	1	in_pdb 3HJB	No	VC0374	15640401	pgi	glucose-6-phosphate isomerase	550	Drug Target Function	Phase 2: March 2008	3HJB	99.8%	Vibrio cholerae	Energy metabolism	Glycolysis/gluconeogenesis

IDP01650 (show subtarget assignments)	1	in_pdb 3IFS	No	GBAA5130	47530435	pgi	glucose-6-phosphate isomerase [Bacillus ...	450	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IFS	100%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP90667 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1535c	15792843	pgi	glucose-6-phosphate isomerase [Campyloba...	406	Predicted Essential	Community Requests	1ZZG	30.3%	Campylobacter jejuni

IDP02733 (show subtarget assignments)	1	in_pdb 3M5P 3Q7I 3Q88 3LJK	Yes	FTT1315c	56708372	pgi	glucose-6-phosphate isomerase [Francisel...	540	Conserved; Drug target functions	Phase 3: June 2008	3LJK	99.8%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00638 (show subtarget assignments)	1	purified	No	SACOL2736	57285290	gidB	glucose-inhibited division protein B	239	Drug Target Function	Phase 2: March 2008	1XDZ	63.2%	Staphylococcus aureus	Unknown function	General

IDP01237 (show subtarget assignments)	1	purified	No	BA_5563	46396830		Glucose-specific phosphotransferase enzy...	165	Drug Target Function	Phase 2: March 2008	1GGR	46.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01065 (show subtarget assignments)	1	expressed	No	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02065 (show subtarget assignments)	1	in_pdb 3IAC	No	STM3137	16766437		glucuronate isomerase [Salmonella typhim...	470	Conserved; Drug target functions	Phase 3: June 2008	3IAC	100%	Salmonella enterica	Energy metabolism	Sugars

IDP01985 (show subtarget assignments)	1	expressed	No	CBU_1882	29542439	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	435	Conserved; Drug target functions	Phase 3: June 2008	4E77	60.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01882 (show subtarget assignments)	1	soluble	No	FTT0927	56708027	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	431	Drug Target	Phase 3: June 2008	4E77	58.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02781 (show subtarget assignments)	1	in_pdb 3K28	No	GBAA4693	47529992	hemL-2	glutamate-1-semialdehyde aminotransferas...	429	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K28	100%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02280 (show subtarget assignments)	1	in_pdb 3L44	Yes	GBAA0531	47525801	hemL-1	glutamate-1-semialdehyde aminotransferas...	434	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L44	99.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90727 (show subtarget assignments)	8	cloned	No	Cj0853c	15792191	hemL	glutamate-1-semialdehyde aminotransferas...	424	Predicted Essential	Community Requests	3BS8	51.2%	Campylobacter jejuni

IDP90615 (show subtarget assignments)	8	in_crystallization_trials	No	VC0626	15640646		glutamate-1-semialdehyde aminotransferas...	432	Predicted Essential	Community Requests	4E77	72%	Vibrio cholerae

IDP90789 (show subtarget assignments)	8	in_pdb 4E77	No	YPO3389	16123538	hemL	glutamate-1-semialdehyde aminotransferas...	426	Predicted Essential	Community Requests	4E77	100%	Yersinia pestis

IDP04446 (show subtarget assignments)	1	cloned	No	YPO0653	115346457	glnE	glutamate-ammonia-ligase adenylyltransfe...	951	conserved gene; putative drug target function;	Phase 4: April 2009	3K7D	38.5%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP90988 (show subtarget assignments)	8	expressed	No	y1189	22125092	gltI	glutamate and aspartate transporter subu...	305	other biological interest / -	Community Requests	2IA4	75.7%	Yersinia pestis

IDP00933 (show subtarget assignments)	1	purified	No	STM0662	16764039	gltL	glutamate/aspartate transporter	241	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01828 (show subtarget assignments)	1	in_pdb 3NZT	Yes	FTT0367c	56707518	gshA	glutamate--cysteine ligase [Francisella ...	501	Drug Target	Phase 3: June 2008	3NZT	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP90758 (show subtarget assignments)	8	cloned	No	VC1149	15641162		glutamate decarboxylase, putative [Vibri...	548	Predicted Essential	Community Requests	2OKJ	26.1%	Vibrio cholerae

IDP02337 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1511	47526786	gdhA	glutamate dehydrogenase [Bacillus anthra...	428	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K8Z	84.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP00007 (show subtarget assignments)	0	work_stopped	No	BA_0847	30254435	racE-1	glutamate racemase	276	Drug Target Homolog	Phase 1: October 2007	2DWU	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00018 (show subtarget assignments)	0	work_stopped	No	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01362 (show subtarget assignments)	1	purified	No	VC0158	15640188		glutamate racemase	265	Drug Target Function	Phase 2: March 2008	2JFN	49.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00335 (show subtarget assignments)	1	in_pdb 3OUT	No	FTT1197c	56708260	murI	glutamate racemase	265	Drug Target Function	Phase 2: March 2008	3OUT	100%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00328 (show subtarget assignments)	1	in_pdb 3UHP 3UHF 3UHO	No	Cj1652c	15792957	murI	glutamate racemase	250	Drug Target Function	Phase 2: March 2008	2JFX	53.7%	Campylobacter jejuni	Energy metabolism	Pentose phosphate pathway

IDP00309 (show subtarget assignments)	1	expressed	No	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597 (show subtarget assignments)	1	purified	No	YPO3909	16124041	murI	glutamate racemase	287	Conserved Gene / Pathway	Phase 2: March 2008	2JFN	71.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05326 (show subtarget assignments)	1	cloned	No	CD3562	126701188	murI	glutamate racemase [Clostridium difficil...	268	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3OUT	45.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01627 (show subtarget assignments)	1	cloned	No	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	Phase 3: June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP04413 (show subtarget assignments)	1	cloned	No	VC2373	15642370		glutamate synthase, large subunit [Vibri...	1530	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1LLW	44.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP01053 (show subtarget assignments)	1	cloned	No	STM3330	16766625	gltB	glutamate synthase subunit alpha	1486	Conserved Gene / Pathway	Phase 2: March 2008	1EA0	45.2%	Salmonella enterica	Central intermediary metabolism	Other

IDP02086 (show subtarget assignments)	1	cloned	No	YPO3557	161486860	gltB	glutamate synthase subunit alpha [Yersin...	1538	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1EA0	45%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP00481 (show subtarget assignments)	1	expressed	No	YPO3558	16123702	gltD	glutamate synthase subunit beta	472	Virulence Associated Factor	Phase 2: March 2008	2VDC	43.2%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP00939 (show subtarget assignments)	1	expressed	No	STM0828	16764190	glnQ	glutamine ABC transporter ATP-binding pr...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00474 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2512	16122733	glnH	glutamine ABC transporter periplasmic pr...	247	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	78.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP92017 (show subtarget assignments)	8	selected	No	ADC80544	289064337		glutamine aminoacyl-tRNA synthetase [Tox...	937	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1EUQ	31.2%	Toxoplasma gondii

IDP02102 (show subtarget assignments)	1	cloned	No	CBU_0503	29541108	glnA	glutamine synthetase [Coxiella burnetii ...	359	Conserved; Drug target functions	Phase 3: June 2008	3FKY	49.9%	Coxiella burnetii	Amino acid biosynthesis	Glutamate family

IDP92120 (show subtarget assignments)	8	selected	No	TGME49_073490	237833305		glutamine synthetase, putative [Toxoplas...	579	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3NG0	43.4%	Toxoplasma gondii

IDP00839 (show subtarget assignments)	1	purified	No	SACOL1328	57284485	glnR	glutamine synthetase repressor	122	Conserved Gene / Pathway	Phase 2: March 2008	3HH0	24.6%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP02718 (show subtarget assignments)	1	cloned	No	GBAA3833	47529118	glnA	glutamine synthetase, type I [Bacillus a...	444	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3QAJ	86.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP05277 (show subtarget assignments)	1	expressed	No	YPO2630	16122843	glnS	glutaminyl-tRNA synthetase [Yersinia pes...	598	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1O0B	80.3%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP00683 (show subtarget assignments)	1	purified	No	SACOL1795	57286229	pepA1	glutamyl aminopeptidase	358	Drug Target Function	Phase 2: March 2008	3KL9	38.8%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05342 (show subtarget assignments)	1	soluble	No	YPO3398	16123547	-	glutamyl-Q tRNA(Asp) synthetase [Yersini...	384	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	52.1%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP02777 (show subtarget assignments)	1	soluble	No	GBAA4698	47529997	hemA	glutamyl-tRNA reductase [Bacillus anthra...	444	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	27.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90674 (show subtarget assignments)	8	cloned	No	Cj0542	15791903	hemA	glutamyl-tRNA reductase [Campylobacter j...	432	Predicted Essential	Community Requests	1GPJ	27.3%	Campylobacter jejuni

IDP02522 (show subtarget assignments)	1	expressed	No	CBU_1966	29542521	hemA	glutamyl-tRNA reductase [Coxiella burnet...	413	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	30.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02291 (show subtarget assignments)	1	cloned	No	FTT0167	56707337	hemA	glutamyl-tRNA reductase [Francisella tul...	416	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	26.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04169 (show subtarget assignments)	1	in_crystallization_trials	No	VC2180	15642179	hemA	glutamyl-tRNA reductase [Vibrio cholerae...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPJ	35.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91454 (show subtarget assignments)	8	cloned	No	VV1_0254	27363735	hemA	glutamyl-tRNA reductase [Vibrio vulnific...	419	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GPJ	36.3%	Vibrio vulnificus

IDP90936 (show subtarget assignments)	8	cloned	No	YPO2016	16122259	hemA	glutamyl-tRNA reductase [Yersinia pestis...	420	Predicted Essential	Community Requests	1GPJ	32.9%	Yersinia pestis

IDP04577 (show subtarget assignments)	1	cloned	No	BAS0087	49183121		glutamyl-tRNA synthetase [Bacillus anthr...	485	Proposed to be essential proteins	Phase 4: April 2009	2O5R	44.4%	Bacillus anthracis

IDP90662 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1288c	15792611	gltX	glutamyl-tRNA synthetase [Campylobacter ...	463	Predicted Essential	Community Requests	2CFO	38.9%	Campylobacter jejuni

IDP90858 (show subtarget assignments)	8	in_crystallization_trials	No	O31153	30179879		Glutamyl-tRNA synthetase (Glutamate--tRN...	474	Predicted Essential	Community Requests	2CFO	40.2%	Vibrio cholerae

IDP05224 (show subtarget assignments)	1	cloned	No	VC_0595	9655026		glutamyl-tRNA synthetase-related protein...	304	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	55.3%	Vibrio cholerae	Unknown function: General

IDP05769 (show subtarget assignments)	1	cloned	No	SACOL0574	57651404	gltX	glutamyl-tRNA synthetase [Staphylococcus...	484	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2O5R	43.2%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90921 (show subtarget assignments)	8	purified	No	YPO2984	16123165	gltX	glutamyl-tRNA synthetase [Yersinia pesti...	471	Predicted Essential	Community Requests	2CFO	38.4%	Yersinia pestis

IDP01801 (show subtarget assignments)	1	in_pdb 3MSZ 3LGC	No	FTT0533c	56707666	grxA	glutaredoxin 1 [Francisella tularensis s...	86	Drug Target	Phase 3: June 2008	3LGC	100%	Francisella tularensis	Energy metabolism	Electron transport

IDP00895 (show subtarget assignments)	1	in_pdb 3IR4	Yes	STM1165	16764521	grxB	glutaredoxin 2	215	Conserved Gene / Pathway	Phase 2: March 2008	3IR4	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP02752 (show subtarget assignments)	1	crystallized	No	FTT0650c	56707772	grxB	glutaredoxin 2 [Francisella tularensis s...	214	Drug Target	Phase 3: June 2008	3IR4	30.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP01063 (show subtarget assignments)	1	soluble	No	STM3702	16766987	grxC	glutaredoxin 3	83	Conserved Gene / Pathway	Phase 2: March 2008	1FOV	86.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP02805
(show subtarget assignments)

1

expressed

No

Cj1129c

15792454

wlaC

general glycosylation pathway protein [C...

359

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

3L01

26.5%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01720
(show subtarget assignments)

1

cloned

No

Cj1128c

15792453

wlaD

general glycosylation pathway protein [C...

309

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

3BCV

16.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02634
(show subtarget assignments)

1

cloned

No

Cj1125c

15792450

wlaG

general glycosylation pathway protein [C...

376

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

2JJM

22.6%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP04716
(show subtarget assignments)

1

cloned

No

YPO0817

218927996

general secretion pathway protein C [Yer...

167

putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04449
(show subtarget assignments)

1

cloned

No

YPO0816

218927995

general secretion pathway protein D [Yer...

640

putative drug target function;

Phase 4: April 2009

3EZJ

15.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02238
(show subtarget assignments)

1

expressed

No

YPO0815

16121126

general secretion pathway protein E [Yer...

503

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

48.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04715
(show subtarget assignments)

1

expressed

No

YPO0813

115346604

general secretion pathway protein G [Yer...

145

drug target; putative drug target function;

Phase 4: April 2009

3G20

51%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04292
(show subtarget assignments)

1

cloned

No

YPO0812

218927992

general secretion pathway protein H [Yer...

180

conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04138
(show subtarget assignments)

1

expressed

No

YPO0811

218927991

general secretion pathway protein I [Yer...

114

putative drug target function;

Phase 4: April 2009

3CI0

19.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04448
(show subtarget assignments)

1

cloned

No

YPO0810

218927990

general secretion pathway protein J [Yer...

198

putative drug target function;

Phase 4: April 2009

2RET

20.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04285
(show subtarget assignments)

1

expressed

No

YPO0809

218927989

general secretion pathway protein K [Yer...

318

putative drug target function;

Phase 4: April 2009

3CI0

18.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04284
(show subtarget assignments)

1

cloned

No

YPO0808

218927988

general secretion pathway protein L [Yer...

389

putative drug target function;

Phase 4: April 2009

1W97

13.1%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP01255
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5132

30259616

yugI

general stress protein 13

114

Conserved Gene / Pathway

Phase 2: March 2008

2K4K

53.3%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01540
(show subtarget assignments)

1

in_pdb
3EC6

No

GBAA0418

47525694

general stress protein 26 [Bacillus anth...

138

CONSERVED

Phase 3: June 2008

3EC6

100%

Bacillus anthracis

IDP91951
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100010278

298255964

general stress protein GSP-781 [Streptoc...

392

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2K3A

9.4%

Streptococcus pneumoniae

IDP91796
(show subtarget assignments)

8

in_crystallization_trials

No

AAB49832

1854639

gentamicin resistance protein [Enterococ...

306

other biological interest / Kinase

Community Requests

3TDV

100%

Enterococcus gallinarum

IDP05732
(show subtarget assignments)

1

cloned

No

CD1205

126698801

ispA

geranyltranstransferase [Clostridium dif...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J1P

45.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP02624
(show subtarget assignments)

1

soluble

No

FTT1562

56708589

ispA

geranyltranstransferase [Francisella tul...

293

Conserved; Drug target functions

Phase 3: June 2008

2FOR

40.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02030
(show subtarget assignments)

1

expressed

No

CBU_1255

29541825

geranyltranstransferase, putative [Coxie...

267

Conserved; Drug target functions

Phase 3: June 2008

3TS7

40.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90890
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3176

16123338

ispA

geranyltranstransferase [Yersinia pestis...

306

Predicted Essential

Community Requests

2FOR

70.9%

Yersinia pestis

IDP04203
(show subtarget assignments)

1

selected

No

CPF_2298

110800865

gpr

germination protease [Clostridium perfri...

325

conserved gene; putative drug target function;

Phase 4: April 2009

1C8B

42.3%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4546

33301122

Germination protease precursor (Spore pr...

368

Drug Target Function

Phase 2: March 2008

1C8B

70.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05489
(show subtarget assignments)

1

soluble

No

CD0106

126697677

cwlD

germination-specific N-acetylmuramoyl-L-...

250

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JWQ

25.6%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP91424
(show subtarget assignments)

8

expressed

No

VV1_0551

27364013

GGDEF domain-containing protein [Vibrio ...

591

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3BRE

14%

Vibrio vulnificus

IDP90962
(show subtarget assignments)

8

purified

No

VC2750

81544306

GGDEF family protein

849

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

2R6O

13%

Vibrio cholerae

IDP90961
(show subtarget assignments)

8

purified

No

VP0117

81728759

GGDEF family protein

848

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

12.3%

Vibrio parahaemolyticus

IDP02350
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2977

16123158

glk

glucokinase [Yersinia pestis CO92]

323

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1Q18

78.6%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00829
(show subtarget assignments)

1

purified

No

SACOL2515

57285199

gntK

gluconokinase

517

Drug Target Function

Phase 2: March 2008

3GBT

39.3%

Staphylococcus aureus

Energy metabolism

Sugars

IDP01344
(show subtarget assignments)

1

crystallized

No

VCA1025

15601778

nagB

glucosamine-6-phosphate deaminase

266

Drug Target Function

Phase 2: March 2008

1CD5

79.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP00340
(show subtarget assignments)

1

in_pdb
3TBF

No

FTT0388

56707537

glmS

Glucosamine--fructose-6-phosphate aminot...

612

Drug Target Function

Phase 2: March 2008

3TBF

60.8%

Francisella tularensis

Central intermediary metabolism

Amino sugars

IDP05186
(show subtarget assignments)

1

cloned

No

CD0120

126697692

glmS

glucosamine--fructose-6-phosphate aminot...

610

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JXA

47.1%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP01927
(show subtarget assignments)

1

expressed

No

CBU_1787

29542344

glmS

glucosamine--fructose-6-phosphate aminot...

611

Conserved; Drug target functions

Phase 3: June 2008

1JXA

58.3%

Coxiella burnetii

Central intermediary metabolism

Amino sugars

IDP01606
(show subtarget assignments)

1

cloned

No

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP00110
(show subtarget assignments)

1

purified

No

NT01SF4145

30043548

glgC

glucose-1-phosphate adenylyltransferase ...

431

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3BRK

55.2%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04623
(show subtarget assignments)

1

expressed

No

BAS4760

49187751

glucose-1-phosphate adenylyltransferase ...

376

Proposed to be essential proteins

Phase 4: April 2009

3BRK

40%

Bacillus anthracis

IDP01254
(show subtarget assignments)

1

in_pdb
4ECM
3HL3

Yes

BA_1228

30255177

glucose-1-phosphate thymidylyltransferas...

245

Conserved Gene / Pathway

Phase 2: March 2008

3HL3

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90675
(show subtarget assignments)

8

cloned

No

YPO3861

16123996

rffH

glucose-1-phosphate thymidylyltransferas...

293

Predicted Essential

Community Requests

1MC3

86.7%

Yersinia pestis

IDP92016
(show subtarget assignments)

8

selected

No

TGME49_078830

237842577

glucose-6-phosphate dehydrogenase, putat...

878

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BH9

27.8%

Toxoplasma gondii

IDP00736
(show subtarget assignments)

1

in_pdb
3FF1

No

SACOL0966

57285840

pgi

glucose-6-phosphate isomerase

443

Drug Target Function

Phase 2: March 2008

3FF1

100%

Staphylococcus aureus

Energy metabolism

Glycolysis/gluconeogenesis

IDP01329
(show subtarget assignments)

1

in_pdb
3HJB

No

VC0374

15640401

pgi

glucose-6-phosphate isomerase

550

Drug Target Function

Phase 2: March 2008

3HJB

99.8%

Vibrio cholerae

Energy metabolism

Glycolysis/gluconeogenesis

IDP01650
(show subtarget assignments)

1

in_pdb
3IFS

No

GBAA5130

47530435

pgi

glucose-6-phosphate isomerase [Bacillus ...

450

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IFS

100%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP90667
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1535c

15792843

pgi

glucose-6-phosphate isomerase [Campyloba...

406

Predicted Essential

Community Requests

1ZZG

30.3%

Campylobacter jejuni

IDP02733
(show subtarget assignments)

1

in_pdb
3M5P
3Q7I
3Q88
3LJK

Yes

FTT1315c

56708372

pgi

glucose-6-phosphate isomerase [Francisel...

540

Conserved; Drug target functions

Phase 3: June 2008

3LJK

99.8%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00638
(show subtarget assignments)

1

purified

No

SACOL2736

57285290

gidB

glucose-inhibited division protein B

239

Drug Target Function

Phase 2: March 2008

1XDZ

63.2%

Staphylococcus aureus

Unknown function

General

IDP01237
(show subtarget assignments)

1

purified

No

BA_5563

46396830

Glucose-specific phosphotransferase enzy...

165

Drug Target Function

Phase 2: March 2008

1GGR

46.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01065
(show subtarget assignments)

1

expressed

No

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02065
(show subtarget assignments)

1

in_pdb
3IAC

No

STM3137

16766437

glucuronate isomerase [Salmonella typhim...

470

Conserved; Drug target functions

Phase 3: June 2008

3IAC

100%

Salmonella enterica

Energy metabolism

Sugars

IDP01985
(show subtarget assignments)

1

expressed

No

CBU_1882

29542439

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

435

Conserved; Drug target functions

Phase 3: June 2008

4E77

60.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01882
(show subtarget assignments)

1

soluble

No

FTT0927

56708027

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

431

Drug Target

Phase 3: June 2008

4E77

58.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02781
(show subtarget assignments)

1

in_pdb
3K28

No

GBAA4693

47529992

hemL-2

glutamate-1-semialdehyde aminotransferas...

429

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K28

100%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02280
(show subtarget assignments)

1

in_pdb
3L44

Yes

GBAA0531

47525801

hemL-1

glutamate-1-semialdehyde aminotransferas...

434

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L44

99.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90727
(show subtarget assignments)

8

cloned

No

Cj0853c

15792191

hemL

glutamate-1-semialdehyde aminotransferas...

424

Predicted Essential

Community Requests

3BS8

51.2%

Campylobacter jejuni

IDP90615
(show subtarget assignments)

8

in_crystallization_trials

No

VC0626

15640646

glutamate-1-semialdehyde aminotransferas...

432

Predicted Essential

Community Requests

4E77

72%

Vibrio cholerae

IDP90789
(show subtarget assignments)

8

in_pdb
4E77

No

YPO3389

16123538

hemL

glutamate-1-semialdehyde aminotransferas...

426

Predicted Essential

Community Requests

4E77

100%

Yersinia pestis

IDP04446
(show subtarget assignments)

1

cloned

No

YPO0653

115346457

glnE

glutamate-ammonia-ligase adenylyltransfe...

951

conserved gene; putative drug target function;

Phase 4: April 2009

3K7D

38.5%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP90988
(show subtarget assignments)

8

expressed

No

y1189

22125092

gltI

glutamate and aspartate transporter subu...

305

other biological interest / -

Community Requests

2IA4

75.7%

Yersinia pestis

IDP00933
(show subtarget assignments)

1

purified

No

STM0662

16764039

gltL

glutamate/aspartate transporter

241

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01828
(show subtarget assignments)

1

in_pdb
3NZT

Yes

FTT0367c

56707518

gshA

glutamate--cysteine ligase [Francisella ...

501

Drug Target

Phase 3: June 2008

3NZT

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP90758
(show subtarget assignments)

8

cloned

No

VC1149

15641162

glutamate decarboxylase, putative [Vibri...

548

Predicted Essential

Community Requests

2OKJ

26.1%

Vibrio cholerae

IDP02337
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1511

47526786

gdhA

glutamate dehydrogenase [Bacillus anthra...

428

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K8Z

84.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP00007
(show subtarget assignments)

0

work_stopped

No

BA_0847

30254435

racE-1

glutamate racemase

276

Drug Target Homolog

Phase 1: October 2007

2DWU

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00018
(show subtarget assignments)

0

work_stopped

No

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01362
(show subtarget assignments)

1

purified

No

VC0158

15640188

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

2JFN

49.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00335
(show subtarget assignments)

1

in_pdb
3OUT

No

FTT1197c

56708260

murI

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

3OUT

100%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00328
(show subtarget assignments)

1

in_pdb
3UHP
3UHF
3UHO

No

Cj1652c

15792957

murI

glutamate racemase

250

Drug Target Function

Phase 2: March 2008

2JFX

53.7%

Campylobacter jejuni

Energy metabolism

Pentose phosphate pathway

IDP00309
(show subtarget assignments)

1

expressed

No

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597
(show subtarget assignments)

1

purified

No

YPO3909

16124041

murI

glutamate racemase

287

Conserved Gene / Pathway

Phase 2: March 2008

2JFN

71.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05326
(show subtarget assignments)

1

cloned

No

CD3562

126701188

murI

glutamate racemase [Clostridium difficil...

268

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3OUT

45.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01627
(show subtarget assignments)

1

cloned

No

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

Phase 3: June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP04413
(show subtarget assignments)

1

cloned

No

VC2373

15642370

glutamate synthase, large subunit [Vibri...

1530

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1LLW

44.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family

IDP01053
(show subtarget assignments)

1

cloned

No

STM3330

16766625

gltB

glutamate synthase subunit alpha

1486

Conserved Gene / Pathway

Phase 2: March 2008

1EA0

45.2%

Salmonella enterica

Central intermediary metabolism

Other

IDP02086
(show subtarget assignments)

1

cloned

No

YPO3557

161486860

gltB

glutamate synthase subunit alpha [Yersin...

1538

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1EA0

45%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP00481
(show subtarget assignments)

1

expressed

No

YPO3558

16123702

gltD

glutamate synthase subunit beta

472

Virulence Associated Factor

Phase 2: March 2008

2VDC

43.2%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP00939
(show subtarget assignments)

1

expressed

No

STM0828

16764190

glnQ

glutamine ABC transporter ATP-binding pr...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00474
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2512

16122733

glnH

glutamine ABC transporter periplasmic pr...

247

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

78.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP92017
(show subtarget assignments)

8

selected

No

ADC80544

289064337

glutamine aminoacyl-tRNA synthetase [Tox...

937

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1EUQ

31.2%

Toxoplasma gondii

IDP02102
(show subtarget assignments)

1

cloned

No

CBU_0503

29541108

glnA

glutamine synthetase [Coxiella burnetii ...

359

Conserved; Drug target functions

Phase 3: June 2008

3FKY

49.9%

Coxiella burnetii

Amino acid biosynthesis

Glutamate family

IDP92120
(show subtarget assignments)

8

selected

No

TGME49_073490

237833305

glutamine synthetase, putative [Toxoplas...

579

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3NG0

43.4%

Toxoplasma gondii

IDP00839
(show subtarget assignments)

1

purified

No

SACOL1328

57284485

glnR

glutamine synthetase repressor

122

Conserved Gene / Pathway

Phase 2: March 2008

3HH0

24.6%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP02718
(show subtarget assignments)

1

cloned

No

GBAA3833

47529118

glnA

glutamine synthetase, type I [Bacillus a...

444

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3QAJ

86.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP05277
(show subtarget assignments)

1

expressed

No

YPO2630

16122843

glnS

glutaminyl-tRNA synthetase [Yersinia pes...

598

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1O0B

80.3%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP00683
(show subtarget assignments)

1

purified

No

SACOL1795

57286229

pepA1

glutamyl aminopeptidase

358

Drug Target Function

Phase 2: March 2008

3KL9

38.8%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05342
(show subtarget assignments)

1

soluble

No

YPO3398

16123547

-

glutamyl-Q tRNA(Asp) synthetase [Yersini...

384

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

52.1%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP02777
(show subtarget assignments)

1

soluble

No

GBAA4698

47529997

hemA

glutamyl-tRNA reductase [Bacillus anthra...

444

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

27.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90674
(show subtarget assignments)

8

cloned

No

Cj0542

15791903

hemA

glutamyl-tRNA reductase [Campylobacter j...

432

Predicted Essential

Community Requests

1GPJ

27.3%

Campylobacter jejuni

IDP02522
(show subtarget assignments)

1

expressed

No

CBU_1966

29542521

hemA

glutamyl-tRNA reductase [Coxiella burnet...

413

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

30.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02291
(show subtarget assignments)

1

cloned

No

FTT0167

56707337

hemA

glutamyl-tRNA reductase [Francisella tul...

416

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

26.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04169
(show subtarget assignments)

1

in_crystallization_trials

No

VC2180

15642179

hemA

glutamyl-tRNA reductase [Vibrio cholerae...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPJ

35.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91454
(show subtarget assignments)

8

cloned

No

VV1_0254

27363735

hemA

glutamyl-tRNA reductase [Vibrio vulnific...

419

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GPJ

36.3%

Vibrio vulnificus

IDP90936
(show subtarget assignments)

8

cloned

No

YPO2016

16122259

hemA

glutamyl-tRNA reductase [Yersinia pestis...

420

Predicted Essential

Community Requests

1GPJ

32.9%

Yersinia pestis

IDP04577
(show subtarget assignments)

1

cloned

No

BAS0087

49183121

glutamyl-tRNA synthetase [Bacillus anthr...

485

Proposed to be essential proteins

Phase 4: April 2009

2O5R

44.4%

Bacillus anthracis

IDP90662
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1288c

15792611

gltX

glutamyl-tRNA synthetase [Campylobacter ...

463

Predicted Essential

Community Requests

2CFO

38.9%

Campylobacter jejuni

IDP90858
(show subtarget assignments)

8

in_crystallization_trials

No

O31153

30179879

Glutamyl-tRNA synthetase (Glutamate--tRN...

474

Predicted Essential

Community Requests

2CFO

40.2%

Vibrio cholerae

IDP05224
(show subtarget assignments)

1

cloned

No

VC_0595

9655026

glutamyl-tRNA synthetase-related protein...

304

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

55.3%

Vibrio cholerae

Unknown function: General

IDP05769
(show subtarget assignments)

1

cloned

No

SACOL0574

57651404

gltX

glutamyl-tRNA synthetase [Staphylococcus...

484

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2O5R

43.2%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90921
(show subtarget assignments)

8

purified

No

YPO2984

16123165

gltX

glutamyl-tRNA synthetase [Yersinia pesti...

471

Predicted Essential

Community Requests

2CFO

38.4%

Yersinia pestis

IDP01801
(show subtarget assignments)

1

in_pdb
3MSZ
3LGC

No

FTT0533c

56707666

grxA

glutaredoxin 1 [Francisella tularensis s...

86

Drug Target

Phase 3: June 2008

3LGC

100%

Francisella tularensis

Energy metabolism

Electron transport

IDP00895
(show subtarget assignments)

1

in_pdb
3IR4

Yes

STM1165

16764521

grxB

glutaredoxin 2

215

Conserved Gene / Pathway

Phase 2: March 2008

3IR4

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP02752
(show subtarget assignments)

1

crystallized

No

FTT0650c

56707772

grxB

glutaredoxin 2 [Francisella tularensis s...

214

Drug Target

Phase 3: June 2008

3IR4

30.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP01063
(show subtarget assignments)

1

soluble

No

STM3702

16766987

grxC

glutaredoxin 3

83

Conserved Gene / Pathway

Phase 2: March 2008

1FOV

86.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs