Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04189 (show subtarget assignments)	1	expressed	No	CPF_0225	110799110		sensor histidine kinase [Clostridium per...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04191 (show subtarget assignments)	1	expressed	No	CPF_0554	110800843		sensor histidine kinase [Clostridium per...	583	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04125 (show subtarget assignments)	1	cloned	No	YPO2847	115348521	yegM	putitive HlyD family secretion protein [...	444	conserved gene; putative drug target function;	Phase 4: April 2009	3FPP	21.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04190 (show subtarget assignments)	1	cloned	No	CPF_0544	110800679	spoVD	stage V sporulation protein D [Clostridi...	721	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	27.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04194 (show subtarget assignments)	1	cloned	No	CPF_2444	110799147	yyaC	putative sporulation protein YyaC [Clost...	176	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04193 (show subtarget assignments)	1	cloned	No	CPF_2398	110799387	mreB	rod shape-determining protein MreB [Clos...	342	conserved gene; putative drug target function;	Phase 4: April 2009	1JCE	53.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04192 (show subtarget assignments)	1	cloned	No	CPF_0671	110799768		phosphoribosylformylglycinamidine syntha...	1266	conserved gene; putative drug target function;	Phase 4: April 2009	3AC6	15.2%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04206 (show subtarget assignments)	1	cloned	No	CPF_2812	110799133	prsA	ribose-phosphate pyrophosphokinase [Clos...	319	conserved gene; putative drug target function;	Phase 4: April 2009	1DKR	63%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04126 (show subtarget assignments)	1	cloned	No	YPO2871	115348542	guaB	inosine-5'-monophosphate dehydrogenase [...	487	conserved gene; putative drug target function;	Phase 4: April 2009	1ZFJ	56.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04253 (show subtarget assignments)	1	purified	No	CPF_1800	110800480	prs	phosphoribosylpyrophosphate synthetase [...	364	conserved gene; putative drug target function;	Phase 4: April 2009	2C4K	25.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04208 (show subtarget assignments)	1	purified	No	CPF_2958	110799195	purA	adenylosuccinate synthetase [Clostridium...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1IWE	47.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04124 (show subtarget assignments)	1	crystallized	No	YPO2828	218929893	purI	phosphoribosylaminoimidazole synthetase ...	347	conserved gene; putative drug target function;	Phase 4: April 2009	1CLI	81.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04042 (show subtarget assignments)	1	cloned	No	CPF_0296	110798725		putative cell division ATP-binding prote...	228	conserved gene; putative drug target function;	Phase 4: April 2009	1F3O	40.6%	Clostridium perfringens	Cellular processes	Cell division

IDP04040 (show subtarget assignments)	1	cloned	No	CPF_1068	110800949	cotJC	spore coat protein CotJC [Clostridium pe...	188	conserved gene; putative drug target function;	Phase 4: April 2009	1JKU	34.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04122 (show subtarget assignments)	1	in_pdb 3OJC	Yes	YPO2758	115348441		putative aspartate/glutamate racemase [Y...	231	conserved gene; putative drug target function;	Phase 4: April 2009	3OJC	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04123 (show subtarget assignments)	1	expressed	No	YPO2768	115348451	accD	acetyl-coenzyme A carboxylase carboxyl t...	304	conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	84.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04016 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0834	110798754	arsC	arsenate reductase ArsC [Clostridium per...	132	conserved gene; putative drug target function;	Phase 4: April 2009	2L17	40.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04087 (show subtarget assignments)	1	cloned	No	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04050 (show subtarget assignments)	1	purified	No	YPO1765	218928887	hpaF	5-carboxymethyl-2-hydroxymuconate delta-...	132	conserved gene; putative drug target function;	Phase 4: April 2009	1OTG	67.4%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04232 (show subtarget assignments)	1	cloned	No	CPF_0693	110799915	aroE	shikimate 5-dehydrogenase [Clostridium p...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3FBT	46.9%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04230 (show subtarget assignments)	1	purified	No	CPF_0678	110801134	purD	phosphoribosylamine--glycine ligase [Clo...	416	conserved gene; putative drug target function;	Phase 4: April 2009	2YW2	51.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04201 (show subtarget assignments)	1	expressed	No	CPF_0499	110800753		sensor histidine kinase [Clostridium per...	431	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP04133 (show subtarget assignments)	1	cloned	No	CPF_1195	110798868	hpkA	sensor histidine kinase [Clostridium per...	287	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	25.8%	Clostridium perfringens	Regulatory functions	Other

IDP04259 (show subtarget assignments)	1	cloned	No	CPF_2018	110799691	ftsZ	cell division protein FtsZ [Clostridium ...	381	conserved gene; putative drug target function;	Phase 4: April 2009	2VAM	58%	Clostridium perfringens	Cellular processes	Cell division

IDP04102 (show subtarget assignments)	1	cloned	No	YPO2227	218929324	pyrF	orotidine 5'-phosphate decarboxylase [Ye...	245	conserved gene; putative drug target function;	Phase 4: April 2009	1EIX	72.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04105 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2391	115348093	ribC	riboflavin synthase alpha chain [Yersini...	218	conserved gene; putative drug target function;	Phase 4: April 2009	1I8D	74.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04032 (show subtarget assignments)	1	cloned	No	CPF_2081	110798910		stage III sporulation protein AG [Clostr...	201	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04154 (show subtarget assignments)	1	cloned	No	YPO4017	218931008	hutU	urocanate hydratase [Yersinia pestis CO9...	563	conserved gene; putative drug target function;	Phase 4: April 2009	1UWL	86.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04247 (show subtarget assignments)	1	expressed	No	CPF_1402	110798994		sensor histidine kinase [Clostridium per...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.3%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04101 (show subtarget assignments)	1	purified	No	CPF_2392	110799105	minE	cell division topological specificity fa...	90	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP04020 (show subtarget assignments)	1	cloned	No	CPF_2112	110800515		cell division protein FtsQ [Clostridium ...	248	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP04082 (show subtarget assignments)	1	cloned	No	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04226 (show subtarget assignments)	1	cloned	No	CPF_0171	110799571	luxS	S-ribosylhomocysteinase [Clostridium per...	151	conserved gene; putative drug target function;	Phase 4: April 2009	1J6W	51%	Clostridium perfringens	Cellular processes	Other

IDP04111 (show subtarget assignments)	1	cloned	No	YPO2524	115348222	menC	putative O-succinylbenzoate-CoA synthase...	323	conserved gene; putative drug target function;	Phase 4: April 2009	3GC2	66.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04036 (show subtarget assignments)	1	cloned	No	CPF_1970	110800938	smc	chromosome segregation protein SMC [Clos...	1185	conserved gene; putative drug target function;	Phase 4: April 2009	3AUX	8.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04205 (show subtarget assignments)	1	soluble	No	CPF_2805	110801373	spoVT	stage V sprulation protein T [Clostridiu...	182	conserved gene; putative drug target function;	Phase 4: April 2009	2W1T	63.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04244 (show subtarget assignments)	1	soluble	No	CPF_1171	110801284		sensor histidine kinase [Clostridium per...	410	conserved gene; putative drug target function;	Phase 4: April 2009	1B3Q	9.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04245 (show subtarget assignments)	1	cloned	No	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04251 (show subtarget assignments)	1	cloned	No	CPF_1751	110801372	virS	sensor histidine kinase VirS [Clostridiu...	440	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04204 (show subtarget assignments)	1	soluble	No	CPF_2382	110799414	obgE	GTPase ObgE [Clostridium perfringens ATC...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1LNZ	44.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04243 (show subtarget assignments)	1	soluble	No	CPF_1140	110799522		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04019 (show subtarget assignments)	1	cloned	No	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009	3TUF	24.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04735 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1494	115347246	chlN	molybdopterin biosynthesis protein [Yers...	255	conserved gene; putative drug target function;	Phase 4: April 2009	1JW9	67.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP04724 (show subtarget assignments)	1	cloned	No	YPO1415	115347174	pyrD	dihydroorotate dehydrogenase [Yersinia p...	336	conserved gene; putative drug target function;	Phase 4: April 2009	1F76	83.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04727 (show subtarget assignments)	1	purified	No	CPF_2072	110800396		hemolysin A [Clostridium perfringens ATC...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3HP7	49.8%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04090 (show subtarget assignments)	1	crystallized	No	CPF_0694	110800453	aroK	shikimate kinase [Clostridium perfringen...	167	conserved gene; putative drug target function;	Phase 4: April 2009	2PT5	34.1%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04723 (show subtarget assignments)	1	cloned	No	YPO1364	115347123		putative HlyD family secretion protein [...	371	conserved gene; putative drug target function;	Phase 4: April 2009	3FPP	62.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04733 (show subtarget assignments)	1	cloned	No	CBU_0789	215919045		two component system histidine kinase [C...	831	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.5%	Coxiella burnetii	Signal transduction	Two-component systems

IDP04719 (show subtarget assignments)	1	expressed	No	YPO1151	218928315	bioB	biotin synthase [Yersinia pestis CO92]	345	conserved gene; putative drug target function;	Phase 4: April 2009	1R30	83.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04721 (show subtarget assignments)	1	expressed	No	YPO1289	115347051		conserved hypothetical protein [Yersinia...	380	conserved gene; putative drug target function;	Phase 4: April 2009	2Q18	16.8%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04717 (show subtarget assignments)	1	cloned	No	YPO0832	218928008	agaZ	putative tagatose 6-phosphate kinase [Ye...	432	conserved gene; putative drug target function;	Phase 4: April 2009	2FIQ	51.6%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04722 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1357	115347116	ltaA	L-allo-threonine aldolase [Yersinia pest...	339	conserved gene; putative drug target function;	Phase 4: April 2009	1LW4	46.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04092 (show subtarget assignments)	1	cloned	No	CPF_1925	110801017	spoVS	stage V sporulation protein S [Clostridi...	86	conserved gene; putative drug target function;	Phase 4: April 2009	2EH1	57%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04704 (show subtarget assignments)	1	cloned	No	YPO0322	115346138	tyrB	aromatic-amino-acid aminotransferase [Ye...	397	conserved gene; putative drug target function;	Phase 4: April 2009	3TAT	75.6%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04713 (show subtarget assignments)	1	purified	No	YPO0533	218927730	leuA	2-isopropylmalate synthase [Yersinia pes...	520	conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	36.3%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP04714 (show subtarget assignments)	1	expressed	No	YPO0672	218927865	parF	putative acyltransferase [Yersinia pesti...	243	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04671 (show subtarget assignments)	1	soluble	No	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP04689 (show subtarget assignments)	1	in_pdb 3PEA	Yes	GBAA4761	47530060		enoyl-CoA hydratase [Bacillus anthracis ...	258	conserved gene; putative drug target function;	Phase 4: April 2009	3PEA	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04656 (show subtarget assignments)	1	cloned	No	FTT1720c	56708726	purL	phosphoribosylformylglycinamidine syntha...	1290	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04659 (show subtarget assignments)	1	soluble	No	GBAA0272	47525531		sensor histidine kinase [Bacillus anthra...	501	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04668 (show subtarget assignments)	1	cloned	No	GBAA1327	47526592		phaP protein [Bacillus anthracis str. 'A...	174	conserved gene; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04694 (show subtarget assignments)	1	soluble	No	GBAA5714	47531051	yycG	sensory box histidine kinase YycG [Bacil...	613	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	15.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04645 (show subtarget assignments)	1	soluble	No	FTT0897	56707998	purK	phosphoribosylaminoimidazole carboxylase...	365	conserved gene; putative drug target function;	Phase 4: April 2009	3AW8	42.7%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04700 (show subtarget assignments)	1	cloned	No	YPO0045	218927266	pyrE	orotate phosphoribosyltransferase [Yersi...	215	conserved gene; putative drug target function;	Phase 4: April 2009	1LH0	85.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04630 (show subtarget assignments)	1	cloned	No	CBU_1228	29654531	qseC	sensor protein qseC [Coxiella burnetii R...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	19%	Coxiella burnetii	Regulatory functions	Other

IDP04633 (show subtarget assignments)	1	in_pdb 4EEI	No	FTT0015	56707195	purB	adenylosuccinate lyase [Francisella tula...	432	conserved gene; putative drug target function;	Phase 4: April 2009	4EEI	100%	Francisella tularensis

IDP04568 (show subtarget assignments)	1	cloned	No	CPF_2087	110800786		stage III sporulation protein AA [Clostr...	294	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04560 (show subtarget assignments)	1	in_pdb 3NUA	Yes	CPF_0673	110799762	purC	phosphoribosylaminoimidazole-succinocarb...	235	conserved gene; putative drug target function;	Phase 4: April 2009	3NUA	100%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04569 (show subtarget assignments)	1	cloned	No	CPF_2242	110799545		sensor histidine kinase [Clostridium per...	620	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04551 (show subtarget assignments)	1	cloned	No	CPF_2912	110800993	maa	maltose transacetylase [Clostridium perf...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1OCX	64.6%	Clostridium perfringens	Cellular processes	Detoxification

IDP04519 (show subtarget assignments)	1	cloned	No	CPF_2988	110798938	soj	sporulation initiation inhibitor protein...	257	conserved gene; putative drug target function;	Phase 4: April 2009	1WCV	43.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04517 (show subtarget assignments)	1	cloned	No	CPF_2840	110799025	ksgA	dimethyladenosine transferase [Clostridi...	285	conserved gene; putative drug target function;	Phase 4: April 2009	3FUT	35.1%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04552 (show subtarget assignments)	1	cloned	No	CPF_2913	110799629	msrA	methionine sulfoxide reductase A [Clostr...	157	conserved gene; putative drug target function;	Phase 4: April 2009	3BQE	52.2%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04514 (show subtarget assignments)	1	cloned	No	CPF_2662	110798713		putative spore-cortex-lytic enzyme [Clos...	200	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04515 (show subtarget assignments)	1	expressed	No	CPF_2673	110799735		putative sensor histidine kinase [Clostr...	583	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04540 (show subtarget assignments)	1	purified	No	CPF_0511	110801291		sensor histidine kinase [Clostridium per...	516	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	18.2%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP04511 (show subtarget assignments)	1	cloned	No	CPF_2297	110798696		stage II sporulation protein P [Clostrid...	361	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04241 (show subtarget assignments)	1	soluble	No	CPF_1112	110801022		sensor histidine kinase [Clostridium per...	574	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Regulatory functions	Protein interactions

IDP04239 (show subtarget assignments)	1	cloned	No	CPF_1057	110799811		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.4%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04490 (show subtarget assignments)	1	in_pdb 3MJF	No	YPO3729	218930734	purD	phosphoribosylamine--glycine ligase [Yer...	428	conserved gene; putative drug target function;	Phase 4: April 2009	3MJF	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04039 (show subtarget assignments)	1	cloned	No	CPF_2446	110800060	spoIIID	stage III sporulation protein D [Clostri...	83	conserved gene; putative drug target function;	Phase 4: April 2009	2L0K	60.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04479 (show subtarget assignments)	1	purified	No	YPO3077	115348733	purK	phosphoribosylaminoimidazole carboxylase...	354	conserved gene; putative drug target function;	Phase 4: April 2009	1B6S	76.8%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04477 (show subtarget assignments)	1	soluble	No	YPO2829	115348505	purN	putative phosphoribosylglycinamide formy...	212	conserved gene; putative drug target function;	Phase 4: April 2009	2GAR	71.7%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04481 (show subtarget assignments)	1	cloned	No	YPO3204	115348844	nmpB	phosphate regulon sensor protein PhoR [Y...	438	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Yersinia pestis	Regulatory functions	Other

IDP04473 (show subtarget assignments)	1	expressed	No	YPO2624	115348316	nagD	putative N-acetylglucosamine metabolism ...	250	conserved gene; putative drug target function;	Phase 4: April 2009	2C4N	86%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04476 (show subtarget assignments)	1	cloned	No	YPO2773	115348456	ubiX	probable 3-octaprenyl-4-hydroxybenzoate ...	190	conserved gene; putative drug target function;	Phase 4: April 2009	1SBZ	51.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04483 (show subtarget assignments)	1	expressed	No	YPO3361	115348990	b2747	4-diphosphocytidyl-2C-methyl-D-erythrito...	241	conserved gene; putative drug target function;	Phase 4: April 2009	1VGT	63.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04464 (show subtarget assignments)	1	purified	No	YPO1972	218929084	hutI	imidazolonepropionase [Yersinia pestis C...	406	conserved gene; putative drug target function;	Phase 4: April 2009	2OOF	54.9%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04469 (show subtarget assignments)	1	cloned	No	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04463 (show subtarget assignments)	1	cloned	No	YPO1959	115347684	narR	nitrate/nitrite sensor protein [Yersinia...	593	conserved gene; putative drug target function;	Phase 4: April 2009	3EZH	8.4%	Yersinia pestis	Energy metabolism	Anaerobic

IDP04471 (show subtarget assignments)	1	purified	No	YPO2370	218929461	pdxH	pyridoxamine 5'-phosphate oxidase [Yersi...	217	conserved gene; putative drug target function;	Phase 4: April 2009	1G76	78.4%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04189
(show subtarget assignments)

1

expressed

No

CPF_0225

110799110

sensor histidine kinase [Clostridium per...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04191
(show subtarget assignments)

1

expressed

No

CPF_0554

110800843

sensor histidine kinase [Clostridium per...

583

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04125
(show subtarget assignments)

1

cloned

No

YPO2847

115348521

yegM

putitive HlyD family secretion protein [...

444

conserved gene; putative drug target function;

Phase 4: April 2009

3FPP

21.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04190
(show subtarget assignments)

1

cloned

No

CPF_0544

110800679

spoVD

stage V sporulation protein D [Clostridi...

721

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

27.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04194
(show subtarget assignments)

1

cloned

No

CPF_2444

110799147

yyaC

putative sporulation protein YyaC [Clost...

176

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04193
(show subtarget assignments)

1

cloned

No

CPF_2398

110799387

mreB

rod shape-determining protein MreB [Clos...

342

conserved gene; putative drug target function;

Phase 4: April 2009

1JCE

53.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04192
(show subtarget assignments)

1

cloned

No

CPF_0671

110799768

phosphoribosylformylglycinamidine syntha...

1266

conserved gene; putative drug target function;

Phase 4: April 2009

3AC6

15.2%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04206
(show subtarget assignments)

1

cloned

No

CPF_2812

110799133

prsA

ribose-phosphate pyrophosphokinase [Clos...

319

conserved gene; putative drug target function;

Phase 4: April 2009

1DKR

63%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04126
(show subtarget assignments)

1

cloned

No

YPO2871

115348542

guaB

inosine-5'-monophosphate dehydrogenase [...

487

conserved gene; putative drug target function;

Phase 4: April 2009

1ZFJ

56.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04253
(show subtarget assignments)

1

purified

No

CPF_1800

110800480

prs

phosphoribosylpyrophosphate synthetase [...

364

conserved gene; putative drug target function;

Phase 4: April 2009

2C4K

25.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04208
(show subtarget assignments)

1

purified

No

CPF_2958

110799195

purA

adenylosuccinate synthetase [Clostridium...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1IWE

47.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04124
(show subtarget assignments)

1

crystallized

No

YPO2828

218929893

purI

phosphoribosylaminoimidazole synthetase ...

347

conserved gene; putative drug target function;

Phase 4: April 2009

1CLI

81.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04042
(show subtarget assignments)

1

cloned

No

CPF_0296

110798725

putative cell division ATP-binding prote...

228

conserved gene; putative drug target function;

Phase 4: April 2009

1F3O

40.6%

Clostridium perfringens

Cellular processes

Cell division

IDP04040
(show subtarget assignments)

1

cloned

No

CPF_1068

110800949

cotJC

spore coat protein CotJC [Clostridium pe...

188

conserved gene; putative drug target function;

Phase 4: April 2009

1JKU

34.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04122
(show subtarget assignments)

1

in_pdb
3OJC

Yes

YPO2758

115348441

putative aspartate/glutamate racemase [Y...

231

conserved gene; putative drug target function;

Phase 4: April 2009

3OJC

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04123
(show subtarget assignments)

1

expressed

No

YPO2768

115348451

accD

acetyl-coenzyme A carboxylase carboxyl t...

304

conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

84.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04016
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0834

110798754

arsC

arsenate reductase ArsC [Clostridium per...

132

conserved gene; putative drug target function;

Phase 4: April 2009

2L17

40.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04087
(show subtarget assignments)

1

cloned

No

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04050
(show subtarget assignments)

1

purified

No

YPO1765

218928887

hpaF

5-carboxymethyl-2-hydroxymuconate delta-...

132

conserved gene; putative drug target function;

Phase 4: April 2009

1OTG

67.4%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04232
(show subtarget assignments)

1

cloned

No

CPF_0693

110799915

aroE

shikimate 5-dehydrogenase [Clostridium p...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3FBT

46.9%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04230
(show subtarget assignments)

1

purified

No

CPF_0678

110801134

purD

phosphoribosylamine--glycine ligase [Clo...

416

conserved gene; putative drug target function;

Phase 4: April 2009

2YW2

51.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04201
(show subtarget assignments)

1

expressed

No

CPF_0499

110800753

sensor histidine kinase [Clostridium per...

431

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP04133
(show subtarget assignments)

1

cloned

No

CPF_1195

110798868

hpkA

sensor histidine kinase [Clostridium per...

287

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

25.8%

Clostridium perfringens

Regulatory functions

Other

IDP04259
(show subtarget assignments)

1

cloned

No

CPF_2018

110799691

ftsZ

cell division protein FtsZ [Clostridium ...

381

conserved gene; putative drug target function;

Phase 4: April 2009

2VAM

58%

Clostridium perfringens

Cellular processes

Cell division

IDP04102
(show subtarget assignments)

1

cloned

No

YPO2227

218929324

pyrF

orotidine 5'-phosphate decarboxylase [Ye...

245

conserved gene; putative drug target function;

Phase 4: April 2009

1EIX

72.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04105
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2391

115348093

ribC

riboflavin synthase alpha chain [Yersini...

218

conserved gene; putative drug target function;

Phase 4: April 2009

1I8D

74.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04032
(show subtarget assignments)

1

cloned

No

CPF_2081

110798910

stage III sporulation protein AG [Clostr...

201

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04154
(show subtarget assignments)

1

cloned

No

YPO4017

218931008

hutU

urocanate hydratase [Yersinia pestis CO9...

563

conserved gene; putative drug target function;

Phase 4: April 2009

1UWL

86.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04247
(show subtarget assignments)

1

expressed

No

CPF_1402

110798994

sensor histidine kinase [Clostridium per...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.3%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04101
(show subtarget assignments)

1

purified

No

CPF_2392

110799105

minE

cell division topological specificity fa...

90

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP04020
(show subtarget assignments)

1

cloned

No

CPF_2112

110800515

cell division protein FtsQ [Clostridium ...

248

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP04082
(show subtarget assignments)

1

cloned

No

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04226
(show subtarget assignments)

1

cloned

No

CPF_0171

110799571

luxS

S-ribosylhomocysteinase [Clostridium per...

151

conserved gene; putative drug target function;

Phase 4: April 2009

1J6W

51%

Clostridium perfringens

Cellular processes

Other

IDP04111
(show subtarget assignments)

1

cloned

No

YPO2524

115348222

menC

putative O-succinylbenzoate-CoA synthase...

323

conserved gene; putative drug target function;

Phase 4: April 2009

3GC2

66.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04036
(show subtarget assignments)

1

cloned

No

CPF_1970

110800938

smc

chromosome segregation protein SMC [Clos...

1185

conserved gene; putative drug target function;

Phase 4: April 2009

3AUX

8.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04205
(show subtarget assignments)

1

soluble

No

CPF_2805

110801373

spoVT

stage V sprulation protein T [Clostridiu...

182

conserved gene; putative drug target function;

Phase 4: April 2009

2W1T

63.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04244
(show subtarget assignments)

1

soluble

No

CPF_1171

110801284

sensor histidine kinase [Clostridium per...

410

conserved gene; putative drug target function;

Phase 4: April 2009

1B3Q

9.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04245
(show subtarget assignments)

1

cloned

No

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04251
(show subtarget assignments)

1

cloned

No

CPF_1751

110801372

virS

sensor histidine kinase VirS [Clostridiu...

440

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04204
(show subtarget assignments)

1

soluble

No

CPF_2382

110799414

obgE

GTPase ObgE [Clostridium perfringens ATC...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1LNZ

44.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04243
(show subtarget assignments)

1

soluble

No

CPF_1140

110799522

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04019
(show subtarget assignments)

1

cloned

No

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

3TUF

24.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04735
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1494

115347246

chlN

molybdopterin biosynthesis protein [Yers...

255

conserved gene; putative drug target function;

Phase 4: April 2009

1JW9

67.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP04724
(show subtarget assignments)

1

cloned

No

YPO1415

115347174

pyrD

dihydroorotate dehydrogenase [Yersinia p...

336

conserved gene; putative drug target function;

Phase 4: April 2009

1F76

83.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04727
(show subtarget assignments)

1

purified

No

CPF_2072

110800396

hemolysin A [Clostridium perfringens ATC...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3HP7

49.8%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04090
(show subtarget assignments)

1

crystallized

No

CPF_0694

110800453

aroK

shikimate kinase [Clostridium perfringen...

167

conserved gene; putative drug target function;

Phase 4: April 2009

2PT5

34.1%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04723
(show subtarget assignments)

1

cloned

No

YPO1364

115347123

putative HlyD family secretion protein [...

371

conserved gene; putative drug target function;

Phase 4: April 2009

3FPP

62.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04733
(show subtarget assignments)

1

cloned

No

CBU_0789

215919045

two component system histidine kinase [C...

831

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.5%

Coxiella burnetii

Signal transduction

Two-component systems

IDP04719
(show subtarget assignments)

1

expressed

No

YPO1151

218928315

bioB

biotin synthase [Yersinia pestis CO92]

345

conserved gene; putative drug target function;

Phase 4: April 2009

1R30

83.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04721
(show subtarget assignments)

1

expressed

No

YPO1289

115347051

conserved hypothetical protein [Yersinia...

380

conserved gene; putative drug target function;

Phase 4: April 2009

2Q18

16.8%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04717
(show subtarget assignments)

1

cloned

No

YPO0832

218928008

agaZ

putative tagatose 6-phosphate kinase [Ye...

432

conserved gene; putative drug target function;

Phase 4: April 2009

2FIQ

51.6%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04722
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1357

115347116

ltaA

L-allo-threonine aldolase [Yersinia pest...

339

conserved gene; putative drug target function;

Phase 4: April 2009

1LW4

46.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04092
(show subtarget assignments)

1

cloned

No

CPF_1925

110801017

spoVS

stage V sporulation protein S [Clostridi...

86

conserved gene; putative drug target function;

Phase 4: April 2009

2EH1

57%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04704
(show subtarget assignments)

1

cloned

No

YPO0322

115346138

tyrB

aromatic-amino-acid aminotransferase [Ye...

397

conserved gene; putative drug target function;

Phase 4: April 2009

3TAT

75.6%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04713
(show subtarget assignments)

1

purified

No

YPO0533

218927730

leuA

2-isopropylmalate synthase [Yersinia pes...

520

conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

36.3%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP04714
(show subtarget assignments)

1

expressed

No

YPO0672

218927865

parF

putative acyltransferase [Yersinia pesti...

243

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04671
(show subtarget assignments)

1

soluble

No

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP04689
(show subtarget assignments)

1

in_pdb
3PEA

Yes

GBAA4761

47530060

enoyl-CoA hydratase [Bacillus anthracis ...

258

conserved gene; putative drug target function;

Phase 4: April 2009

3PEA

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04656
(show subtarget assignments)

1

cloned

No

FTT1720c

56708726

purL

phosphoribosylformylglycinamidine syntha...

1290

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04659
(show subtarget assignments)

1

soluble

No

GBAA0272

47525531

sensor histidine kinase [Bacillus anthra...

501

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04668
(show subtarget assignments)

1

cloned

No

GBAA1327

47526592

phaP protein [Bacillus anthracis str. 'A...

174

conserved gene; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04694
(show subtarget assignments)

1

soluble

No

GBAA5714

47531051

yycG

sensory box histidine kinase YycG [Bacil...

613

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

15.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04645
(show subtarget assignments)

1

soluble

No

FTT0897

56707998

purK

phosphoribosylaminoimidazole carboxylase...

365

conserved gene; putative drug target function;

Phase 4: April 2009

3AW8

42.7%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04700
(show subtarget assignments)

1

cloned

No

YPO0045

218927266

pyrE

orotate phosphoribosyltransferase [Yersi...

215

conserved gene; putative drug target function;

Phase 4: April 2009

1LH0

85.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04630
(show subtarget assignments)

1

cloned

No

CBU_1228

29654531

qseC

sensor protein qseC [Coxiella burnetii R...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

19%

Coxiella burnetii

Regulatory functions

Other

IDP04633
(show subtarget assignments)

1

in_pdb
4EEI

No

FTT0015

56707195

purB

adenylosuccinate lyase [Francisella tula...

432

conserved gene; putative drug target function;

Phase 4: April 2009

4EEI

100%

Francisella tularensis

IDP04568
(show subtarget assignments)

1

cloned

No

CPF_2087

110800786

stage III sporulation protein AA [Clostr...

294

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04560
(show subtarget assignments)

1

in_pdb
3NUA

Yes

CPF_0673

110799762

purC

phosphoribosylaminoimidazole-succinocarb...

235

conserved gene; putative drug target function;

Phase 4: April 2009

3NUA

100%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04569
(show subtarget assignments)

1

cloned

No

CPF_2242

110799545

sensor histidine kinase [Clostridium per...

620

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04551
(show subtarget assignments)

1

cloned

No

CPF_2912

110800993

maa

maltose transacetylase [Clostridium perf...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1OCX

64.6%

Clostridium perfringens

Cellular processes

Detoxification

IDP04519
(show subtarget assignments)

1

cloned

No

CPF_2988

110798938

soj

sporulation initiation inhibitor protein...

257

conserved gene; putative drug target function;

Phase 4: April 2009

1WCV

43.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04517
(show subtarget assignments)

1

cloned

No

CPF_2840

110799025

ksgA

dimethyladenosine transferase [Clostridi...

285

conserved gene; putative drug target function;

Phase 4: April 2009

3FUT

35.1%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04552
(show subtarget assignments)

1

cloned

No

CPF_2913

110799629

msrA

methionine sulfoxide reductase A [Clostr...

157

conserved gene; putative drug target function;

Phase 4: April 2009

3BQE

52.2%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04514
(show subtarget assignments)

1

cloned

No

CPF_2662

110798713

putative spore-cortex-lytic enzyme [Clos...

200

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04515
(show subtarget assignments)

1

expressed

No

CPF_2673

110799735

putative sensor histidine kinase [Clostr...

583

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04540
(show subtarget assignments)

1

purified

No

CPF_0511

110801291

sensor histidine kinase [Clostridium per...

516

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

18.2%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP04511
(show subtarget assignments)

1

cloned

No

CPF_2297

110798696

stage II sporulation protein P [Clostrid...

361

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04241
(show subtarget assignments)

1

soluble

No

CPF_1112

110801022

sensor histidine kinase [Clostridium per...

574

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04239
(show subtarget assignments)

1

cloned

No

CPF_1057

110799811

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.4%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04490
(show subtarget assignments)

1

in_pdb
3MJF

No

YPO3729

218930734

purD

phosphoribosylamine--glycine ligase [Yer...

428

conserved gene; putative drug target function;

Phase 4: April 2009

3MJF

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04039
(show subtarget assignments)

1

cloned

No

CPF_2446

110800060

spoIIID

stage III sporulation protein D [Clostri...

83

conserved gene; putative drug target function;

Phase 4: April 2009

2L0K

60.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04479
(show subtarget assignments)

1

purified

No

YPO3077

115348733

purK

phosphoribosylaminoimidazole carboxylase...

354

conserved gene; putative drug target function;

Phase 4: April 2009

1B6S

76.8%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04477
(show subtarget assignments)

1

soluble

No

YPO2829

115348505

purN

putative phosphoribosylglycinamide formy...

212

conserved gene; putative drug target function;

Phase 4: April 2009

2GAR

71.7%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04481
(show subtarget assignments)

1

cloned

No

YPO3204

115348844

nmpB

phosphate regulon sensor protein PhoR [Y...

438

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Yersinia pestis

Regulatory functions

Other

IDP04473
(show subtarget assignments)

1

expressed

No

YPO2624

115348316

nagD

putative N-acetylglucosamine metabolism ...

250

conserved gene; putative drug target function;

Phase 4: April 2009

2C4N

86%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04476
(show subtarget assignments)

1

cloned

No

YPO2773

115348456

ubiX

probable 3-octaprenyl-4-hydroxybenzoate ...

190

conserved gene; putative drug target function;

Phase 4: April 2009

1SBZ

51.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04483
(show subtarget assignments)

1

expressed

No

YPO3361

115348990

b2747

4-diphosphocytidyl-2C-methyl-D-erythrito...

241

conserved gene; putative drug target function;

Phase 4: April 2009

1VGT

63.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04464
(show subtarget assignments)

1

purified

No

YPO1972

218929084

hutI

imidazolonepropionase [Yersinia pestis C...

406

conserved gene; putative drug target function;

Phase 4: April 2009

2OOF

54.9%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04469
(show subtarget assignments)

1

cloned

No

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04463
(show subtarget assignments)

1

cloned

No

YPO1959

115347684

narR

nitrate/nitrite sensor protein [Yersinia...

593

conserved gene; putative drug target function;

Phase 4: April 2009

3EZH

8.4%

Yersinia pestis

Energy metabolism

Anaerobic

IDP04471
(show subtarget assignments)

1

purified

No

YPO2370

218929461

pdxH

pyridoxamine 5'-phosphate oxidase [Yersi...

217

conserved gene; putative drug target function;

Phase 4: April 2009

1G76

78.4%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

Targets