Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90680 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1401c	15792719	tpiA	triosephosphate isomerase [Campylobacter...	223	Predicted Essential	Community Requests	2JGQ	48.2%	Campylobacter jejuni

IDP90679 (show subtarget assignments)	8	cloned	No	Cj0506	15791868	alaS	alanyl-tRNA synthetase [Campylobacter je...	842	Predicted Essential	Community Requests	3HXU	28.5%	Campylobacter jejuni

IDP90690 (show subtarget assignments)	8	purified	No	Cj1196c	15792520	gpsA	NAD(P)H-dependent glycerol-3-phosphate d...	298	Predicted Essential	Community Requests	1Z82	35.8%	Campylobacter jejuni

IDP90685 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0401	15791768	lysS	lysyl-tRNA synthetase [Campylobacter jej...	501	Predicted Essential	Community Requests	1BBU	48.1%	Campylobacter jejuni

IDP90227 (show subtarget assignments)	0	work_stopped	No	BAS1428	49184445	-	Histidinol-phosphate aminotransferase (E...	370	Histidinol phosphate aminotransferase (EC 2.6.1.9) is a key enzyme on the histid...	January 2009	3FFH	46.2%	Bacillus anthracis

IDP90228 (show subtarget assignments)	1	in_pdb 3T5P 3S40	No	BAS4713	49187704	-	Transcription regulator [contains diacyl...	300	Transcription regulator [contains diacylglycerol kinase catalytic domain]; Predi...	January 2009	3S40	100%	Bacillus anthracis

IDP90222 (show subtarget assignments)	1	in_pdb 3H2Y	No	BAS4233	49187229	YqeH	GTP-binding protein YqeH, possibly invol...	368	YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess in...	January 2009	3H2Y	100%	Bacillus anthracis

IDP90223 (show subtarget assignments)	1	expressed	No	SA1226	15926974	Asd	Aspartate semialdehyde dehydrogenase Asd...	329	This enzyme participates in glycine, serine and threonine metabolism and lysine ...	January 2009	2YV3	43.4%	Staphylococcus aureus

IDP90226 (show subtarget assignments)	1	selected	No	VC2428	9657003		conserved hypothetical protein [Vibrio c...	246	Conserved gene clusters with virulence associated genes. Conserved Protein; Pred...	January 2009	2OEZ	74.8%	Vibrio cholerae

IDP00127 (show subtarget assignments)	1	soluble	No	NT01ST1705	16764721	sufC	cysteine desulfurase ATPase component	248	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2D3W	92.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00063 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4952	30259447		aminoglycoside phosphotransferase family...	263	Virulence	Phase 1: October 2007	3I0O	14.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00126 (show subtarget assignments)	1	soluble	No	NT01ST1449	16764525	mviM	putative virulence protein	307	Virulence	Phase 1: October 2007	1TLT	81.4%	Salmonella enterica	Cellular processes	Pathogenesis

IDP00272 (show subtarget assignments)	1	in_pdb 3EGP 3IRC	No	AF180817_281-775	7329982	N/A	Envelope (E)	495	Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...	Phase 1: October 2007	3G7T	78.8%	Dengue virus		N/A

IDP00062 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4511	50400989		4-hydroxy-3-methylbut-2-enyl diphosphate...	316	Virulence	Phase 1: October 2007	3F7T	35.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00031 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1078	30254808	blaI	penicillinase repressor	132	Virulence	Phase 1: October 2007	1OKR	35.6%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00124 (show subtarget assignments)	0	work_stopped	No	NT01ST0382	16763693	ghmA	phosphoheptose isomerase	192		Phase 1: October 2007	2I22	97.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00003 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0158	47566470	gerXC	spore germination protein xc, (pxo1-112)...	317	Drug Target Homolog	Phase 1: October 2007			Bacillus anthracis

IDP00001 (show subtarget assignments)	1	cloned	No	BA_4599	30259099		aldehyde-alcohol dehydrogenase	867	Drug Target Homolog	Phase 1: October 2007	3MY7	24.5%	Bacillus anthracis	Energy metabolism	Fermentation

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00061 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4399	30258896		hemolysin A	279	Virulence	Phase 1: October 2007	3HP7	58.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00007 (show subtarget assignments)	0	work_stopped	No	BA_0847	30254435	racE-1	glutamate racemase	276	Drug Target Homolog	Phase 1: October 2007	2DWU	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00122 (show subtarget assignments)	1	in_pdb 3CWC	Yes	NT01ST3693	16766265	STM2959	putative glycerate kinase 2	380	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3CWC	100%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00060 (show subtarget assignments)	1	in_pdb 3UH9	Yes	BA_4109	46395774		Metallothiol transferase fosB 2 (Fosfomy...	139	Virulence	Phase 1: October 2007	3UH9	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00030 (show subtarget assignments)	1	purified	No	BA_0926	30254669		tellurium resistance protein, putative	401	Virulence	Phase 1: October 2007	2KXT	16%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00121 (show subtarget assignments)	1	in_pdb 3DQQ	No	NT01ST3629	16766223	ygbK	putative tRNA synthase	420	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DQQ	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00260 (show subtarget assignments)	1	purified	No	AF380138	17529967	N3R	N3R [Monkeypox virus]	176	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007			Monkeypox virus

IDP00120 (show subtarget assignments)	1	expressed	No	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP00015 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4048	47605856		UDP-N-acetylenolpyruvoylglucosamine redu...	301	Drug Target Homolog	Phase 1: October 2007	1HSK	39.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00259 (show subtarget assignments)	1	crystallized	No	CPXV018	30844336	CPXV229 CDS	OMCP protein Cowpox virus	171	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007			Cowpox virus

IDP00258 (show subtarget assignments)	1	in_crystallization_trials	No	MMLVgp1	22550316		Montana myotis leukoencephalitis Envelop...	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.6%	Montana myotis

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP00257 (show subtarget assignments)	1	in_crystallization_trials	No	MODVgp1	20177456		Modoc virus Envelope protein	393	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1SVB	41%	Modoc virus

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP00118 (show subtarget assignments)	1	in_pdb 3MGA	No	NT01ST0713	16763963	fes	enterobactin/ferric enterobactin esteras...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3MGA	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00059 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4013	30258522		fibronectin/fibrinogen-binding protein, ...	569	Virulence	Phase 1: October 2007	3DOA	22.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP00255 (show subtarget assignments)	1	selected	No	NP_041725:276-677	9627243	CFA	Cell fusing agent virus Envelope protein...	402	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3C5X	15.2%	Cell fusing

IDP00254 (show subtarget assignments)	1	in_pdb 3P54	Yes		13272205		Japanese encephalitis virus Envelope pro...	406	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3P54	98.3%	Japanese encephalitis

IDP00117 (show subtarget assignments)	1	purified	No	NT01ST0298	16763632	yaeB	putative regulatory protein	235	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1XQB	47.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00253 (show subtarget assignments)	1	in_crystallization_trials	No	YFVgp1	9627245		Yellow fever virus Envelope protein	399	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1P58	43.8%	Yellow fever

IDP00029 (show subtarget assignments)	1	purified	No	BA_0404	30253939		tellurite resistance protein, putative	360	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00252 (show subtarget assignments)	1	in_crystallization_trials	No		130516		St. Louis encephalitis virus Envelope pr...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	2I69	70.5%	St. Louis

IDP00116 (show subtarget assignments)	0	work_stopped	No	NT01ST0285	16763622	accA	acetylCoA carboxylase, carboxytransferas...	319	Essential	Phase 1: October 2007	2F9Y	96.9%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00058 (show subtarget assignments)	1	soluble	No	BA_3903	30258417		bacteriocin ABC transporter, ATP-binding...	234	Virulence	Phase 1: October 2007	1OXS	32.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00251 (show subtarget assignments)	1	cloned	No	MVEVgp1	9633623		Murray Valley encephalitis Envelope prot...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3P54	78.1%	Murray Valley

IDP00233 (show subtarget assignments)	1	cloned	No	YPO3676	16123819	-	putative phage-related protein	133	Virulence	Phase 1: October 2007	2VO9	25.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00115 (show subtarget assignments)	1	crystallized	No	NT01VPA0514	28900406	VPA0551	hypothetical protein VPA0551 (gi 2890040...	181	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2OT9	33.7%	Vibrio parahaemolyticus	Cellular processes	Toxin production and resistance

IDP00232 (show subtarget assignments)	1	cloned	No	YPO3480	16123626	-	conserved hypothetical protein	292	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00231 (show subtarget assignments)	1	soluble	No	YPO3479	16123625	-	putative protease	331	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00114 (show subtarget assignments)	1	purified	No	GVCV52ORF0478	9654887		Vibrio cholerae O1 biovar eltor str. N16...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3JVU	65.8%	Vibrio cholerae	Cell envelope	Surface structures

IDP00057 (show subtarget assignments)	1	soluble	No	BA_3900	30258414		lantibiotic biosynthesis DNA-binding res...	220	Virulence	Phase 1: October 2007	2GWR	34.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00230 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3444	16123592	-	putative acetyltransferase	167	Virulence	Phase 1: October 2007	2GE3	18%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00229 (show subtarget assignments)	1	soluble	No	YPO0417	16120750	-	putative O-antigen biosynthesis protein	410	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00113 (show subtarget assignments)	0	work_stopped	No	NT01SAA0015	16119212	blaI	PENICILLINASE REPRESSOR	126	Virulence	Phase 1: October 2007	1SD4	100%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00228 (show subtarget assignments)	1	cloned	No	YPO3388	16123537	-	putative chloride channel protein	441	Virulence	Phase 1: October 2007	1KPL	76.6%	Yersinia pestis	Transcription	Transcription factors

IDP00028 (show subtarget assignments)	1	purified	No	BA_0401	30253936		tellurium resistance protein	194	Virulence	Phase 1: October 2007	2KXT	57.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00014 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3915	17368674		Protein recA (Recombinase A)	343	Drug Target Homolog	Phase 1: October 2007	1UBC	65.6%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP00227 (show subtarget assignments)	1	expressed	No	YPO3249	16123408	-	putative amino acid hydrolase	430	Virulence	Phase 1: October 2007	3N5F	36%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00112 (show subtarget assignments)	1	soluble	No	NT01SF5194	30043810	hflK	protease specific for phage lambda cII r...	419	Essential	Phase 1: October 2007	3BK6	11%	Shigella flexneri	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00056 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3898	30258412		choloylglycine hydrolase family protein ...	328	Virulence	Phase 1: October 2007	2OQC	48.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00226 (show subtarget assignments)	1	soluble	No	YPO3938	16124066	glgP	glycogen phosphorylase	815	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 1: October 2007	1EM6	49.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00225 (show subtarget assignments)	1	cloned	No	YPO3069	16123246	-	putative exported protein	486	Virulence	Phase 1: October 2007	3C37	15%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP00111 (show subtarget assignments)	1	in_pdb 3TV9	No	NT02SF4808	30043741	pmbA	putative peptide maturation protein	450	Virulence	Phase 1: October 2007	3TV9	96.2%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00224 (show subtarget assignments)	1	cloned	No	YPO3058	16123235	-	putative membrane protein	288	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00223 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3054	16123231	-	putative carboxypeptidase	225	Virulence	Phase 1: October 2007			Yersinia pestis

IDP00110 (show subtarget assignments)	1	purified	No	NT01SF4145	30043548	glgC	glucose-1-phosphate adenylyltransferase ...	431	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3BRK	55.2%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00055 (show subtarget assignments)	0	work_stopped	No	BA_3696	30258217		blasticidin S deaminase, putative	142	Virulence	Phase 1: October 2007	3B8F	99.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00222 (show subtarget assignments)	1	cloned	No	YPO3049	16123226	-	putative binding protein-dependent trans...	589	Virulence	Phase 1: October 2007	3DKN	15.3%	Yersinia pestis

IDP00221 (show subtarget assignments)	1	soluble	No	YPO0164	16120507	-	putative membrane receptor protein	686	Virulence	Phase 1: October 2007	2HDF	20.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00109 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF4517	30043269	recF	Rec protein	357	Essential	Phase 1: October 2007	2O5V	27.2%	Shigella flexneri	DNA metabolism	DNA replication, recombination, and repair

IDP00220 (show subtarget assignments)	1	purified	No	YPO2855	16123048	-	putative protease	464	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00027 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0400	30253935		tellurium resistance protein	194	Virulence	Phase 1: October 2007	2KXT	56.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00219 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1938	16122184	-	probable deoR-family transcriptional reg...	256	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00108 (show subtarget assignments)	1	purified	No	NT01SF4751	30043076	fdhE	FdhE protein	309	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FIY	39.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00054 (show subtarget assignments)	1	crystallized	No	BA_3600	30258128		acetyltransferase, CYSE/LACA/LPXA/NODL f...	185	Virulence	Phase 1: October 2007	1KHR	42.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00218 (show subtarget assignments)	1	expressed	No	YPO2340	16122564	-	conserved hypothetical protein	256	Virulence	Phase 1: October 2007			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP00217 (show subtarget assignments)	1	cloned	No	YPO2319	16122543	-	putative pepetidase	278	Virulence	Phase 1: October 2007	1AGJ	24.1%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00107 (show subtarget assignments)	1	in_pdb 3DR3	No	NT01SF4834	30043015	argC	N-acetyl-gamma-glutamylphosphate reducta...	334	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DR3	100%	Shigella flexneri	Amino acid biosynthesis	Glutamate family

IDP00216 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2310	16122534	-	putative carboxypeptidase	499	Virulence	Phase 1: October 2007	3DWC	48.1%	Yersinia pestis	Regulatory functions	Other

IDP00215 (show subtarget assignments)	1	cloned	No	YPO2295	16122519	-	haloacid dehalogenase-like hydrolase fam...	224	Virulence	Phase 1: October 2007	3ED5	31.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00106 (show subtarget assignments)	0	work_stopped	No	NT01SF3707	30042635	mdaB	modulator of drug activity B	193	Virulence	Phase 1: October 2007	2AMJ	97.9%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00053 (show subtarget assignments)	1	soluble	No	BA_3536	30258071		phenazine biosynthesis protein, PhzF fam...	285	Virulence	Phase 1: October 2007	1QY9	31.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00214 (show subtarget assignments)	1	expressed	No	YPO2252	16122476	-	putative toxin transport protein	712	Virulence	Phase 1: October 2007	2YL4	26.1%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00213 (show subtarget assignments)	1	soluble	No	YPO0628	16120954	-	putative translational inhibitor protein...	134	Virulence	Phase 1: October 2007	3I7T	35.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00105 (show subtarget assignments)	1	purified	No	NT01SF3662	30042589	S3225	putative class II aminotransferase	116	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2X8U	40.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP00212 (show subtarget assignments)	1	expressed	No	YPO2123	16122358	-	putative phage minor tail protein	236	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00026 (show subtarget assignments)	1	soluble	No	BA_0399	30253934		tellurium resistance protein, putative	198	Virulence	Phase 1: October 2007	3IBZ	41.9%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00013 (show subtarget assignments)	1	soluble	No	BA_3254	30257811		LPXTG-motif cell wall anchor domain prot...	372	Drug Target Homolog	Phase 1: October 2007	1I84	18.3%	Bacillus anthracis	Cell envelope	Other

IDP00211 (show subtarget assignments)	1	purified	No	YPO2101	16122340	-	hypothetical phage protein	211	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00104 (show subtarget assignments)	1	purified	No	NT01SF3305	30042319	srlB	PTS system, glucitol/sorbitol-specific e...	123	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2F9H	25.2%	Shigella flexneri	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00052 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3500	30258038	bla2	beta-lactamase II	256	Virulence	Phase 1: October 2007	1BC2	81.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00210 (show subtarget assignments)	1	crystallized	No	YPO0314	16120652	lexA	LexA repressor	202	Virulence	Phase 1: October 2007	1JHF	91.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00209 (show subtarget assignments)	1	soluble	No	YPO2062	16122301	-	putative M23/M37 peptidase-family protei...	417	Virulence	Phase 1: October 2007	2GU1	32.4%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP00103 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF3270	30042295	ygaC	hypothetical protein S2885	114	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2G7J	86.8%	Shigella flexneri	Cell envelope	Other

IDP00208 (show subtarget assignments)	1	expressed	No	YPO1979	16122221	-	putative dehydrogenase	338	Virulence	Phase 1: October 2007	2PK3	21.3%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00207 (show subtarget assignments)	1	soluble	No	YPO1950	16122196	-	putative peptidase	405	Virulence	Phase 1: October 2007	1WN1	23.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00102 (show subtarget assignments)	1	crystallized	No	NT01SF2944	30042031	evgA	putative positive transcription regulato...	204	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3F6C	64.7%	Shigella flexneri	Cell envelope	Surface structures

IDP00051 (show subtarget assignments)	1	in_pdb 3EDN	Yes	BA_3469	30258008		phenazine biosynthesis protein, PhzF fam...	299	Virulence	Phase 1: October 2007	3EDN	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00206 (show subtarget assignments)	1	soluble	No	YPO1706	16121966	-	putative heat shock protein	293	Virulence	Phase 1: October 2007	3CQB	28.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00205 (show subtarget assignments)	1	cloned	No	YPO1705	16121965	-	tail-specific protease precursor	690	Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...	Phase 1: October 2007	1FC6	15.8%	Yersinia pestis

IDP00101 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF2638	30041803	mrp	putative ATPase	369	Essential	Phase 1: October 2007	2PH1	27.1%	Shigella flexneri	Unknown function	General

IDP90680
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1401c

15792719

tpiA

triosephosphate isomerase [Campylobacter...

223

Predicted Essential

Community Requests

2JGQ

48.2%

Campylobacter jejuni

IDP90679
(show subtarget assignments)

8

cloned

No

Cj0506

15791868

alaS

alanyl-tRNA synthetase [Campylobacter je...

842

Predicted Essential

Community Requests

3HXU

28.5%

Campylobacter jejuni

IDP90690
(show subtarget assignments)

8

purified

No

Cj1196c

15792520

gpsA

NAD(P)H-dependent glycerol-3-phosphate d...

298

Predicted Essential

Community Requests

1Z82

35.8%

Campylobacter jejuni

IDP90685
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0401

15791768

lysS

lysyl-tRNA synthetase [Campylobacter jej...

501

Predicted Essential

Community Requests

1BBU

48.1%

Campylobacter jejuni

IDP90227
(show subtarget assignments)

0

work_stopped

No

BAS1428

49184445

-

Histidinol-phosphate aminotransferase (E...

370

Histidinol phosphate aminotransferase (EC 2.6.1.9) is a key enzyme on the histid...

January 2009

3FFH

46.2%

Bacillus anthracis

IDP90228
(show subtarget assignments)

1

in_pdb
3T5P
3S40

No

BAS4713

49187704

-

Transcription regulator [contains diacyl...

300

Transcription regulator [contains diacylglycerol kinase catalytic domain]; Predi...

January 2009

3S40

100%

Bacillus anthracis

IDP90222
(show subtarget assignments)

1

in_pdb
3H2Y

No

BAS4233

49187229

YqeH

GTP-binding protein YqeH, possibly invol...

368

YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess in...

January 2009

3H2Y

100%

Bacillus anthracis

IDP90223
(show subtarget assignments)

1

expressed

No

SA1226

15926974

Asd

Aspartate semialdehyde dehydrogenase Asd...

329

This enzyme participates in glycine, serine and threonine metabolism and lysine ...

January 2009

2YV3

43.4%

Staphylococcus aureus

IDP90226
(show subtarget assignments)

1

selected

No

VC2428

9657003

conserved hypothetical protein [Vibrio c...

246

Conserved gene clusters with virulence associated genes. Conserved Protein; Pred...

January 2009

2OEZ

74.8%

Vibrio cholerae

IDP00127
(show subtarget assignments)

1

soluble

No

NT01ST1705

16764721

sufC

cysteine desulfurase ATPase component

248

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2D3W

92.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00063
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4952

30259447

aminoglycoside phosphotransferase family...

263

Virulence

Phase 1: October 2007

3I0O

14.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00126
(show subtarget assignments)

1

soluble

No

NT01ST1449

16764525

mviM

putative virulence protein

307

Virulence

Phase 1: October 2007

1TLT

81.4%

Salmonella enterica

Cellular processes

Pathogenesis

IDP00272
(show subtarget assignments)

1

in_pdb
3EGP
3IRC

No

AF180817_281-775

7329982

N/A

Envelope (E)

495

Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...

Phase 1: October 2007

3G7T

78.8%

Dengue virus

N/A

IDP00062
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4511

50400989

4-hydroxy-3-methylbut-2-enyl diphosphate...

316

Virulence

Phase 1: October 2007

3F7T

35.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00031
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1078

30254808

blaI

penicillinase repressor

132

Virulence

Phase 1: October 2007

1OKR

35.6%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00124
(show subtarget assignments)

0

work_stopped

No

NT01ST0382

16763693

ghmA

phosphoheptose isomerase

192

Phase 1: October 2007

2I22

97.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00003
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0158

47566470

gerXC

spore germination protein xc, (pxo1-112)...

317

Drug Target Homolog

Phase 1: October 2007

Bacillus anthracis

IDP00001
(show subtarget assignments)

1

cloned

No

BA_4599

30259099

aldehyde-alcohol dehydrogenase

867

Drug Target Homolog

Phase 1: October 2007

3MY7

24.5%

Bacillus anthracis

Energy metabolism

Fermentation

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00061
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4399

30258896

hemolysin A

279

Virulence

Phase 1: October 2007

3HP7

58.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00007
(show subtarget assignments)

0

work_stopped

No

BA_0847

30254435

racE-1

glutamate racemase

276

Drug Target Homolog

Phase 1: October 2007

2DWU

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00122
(show subtarget assignments)

1

in_pdb
3CWC

Yes

NT01ST3693

16766265

STM2959

putative glycerate kinase 2

380

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3CWC

100%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00060
(show subtarget assignments)

1

in_pdb
3UH9

Yes

BA_4109

46395774

Metallothiol transferase fosB 2 (Fosfomy...

139

Virulence

Phase 1: October 2007

3UH9

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00030
(show subtarget assignments)

1

purified

No

BA_0926

30254669

tellurium resistance protein, putative

401

Virulence

Phase 1: October 2007

2KXT

16%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00121
(show subtarget assignments)

1

in_pdb
3DQQ

No

NT01ST3629

16766223

ygbK

putative tRNA synthase

420

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DQQ

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00260
(show subtarget assignments)

1

purified

No

AF380138

17529967

N3R

N3R [Monkeypox virus]

176

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

Monkeypox virus

IDP00120
(show subtarget assignments)

1

expressed

No

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP00015
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4048

47605856

UDP-N-acetylenolpyruvoylglucosamine redu...

301

Drug Target Homolog

Phase 1: October 2007

1HSK

39.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00259
(show subtarget assignments)

1

crystallized

No

CPXV018

30844336

CPXV229 CDS

OMCP protein Cowpox virus

171

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

Cowpox virus

IDP00258
(show subtarget assignments)

1

in_crystallization_trials

No

MMLVgp1

22550316

Montana myotis leukoencephalitis Envelop...

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.6%

Montana myotis

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP00257
(show subtarget assignments)

1

in_crystallization_trials

No

MODVgp1

20177456

Modoc virus Envelope protein

393

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1SVB

41%

Modoc virus

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP00118
(show subtarget assignments)

1

in_pdb
3MGA

No

NT01ST0713

16763963

fes

enterobactin/ferric enterobactin esteras...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3MGA

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00059
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4013

30258522

fibronectin/fibrinogen-binding protein, ...

569

Virulence

Phase 1: October 2007

3DOA

22.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00255
(show subtarget assignments)

1

selected

No

NP_041725:276-677

9627243

CFA

Cell fusing agent virus Envelope protein...

402

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3C5X

15.2%

Cell fusing

IDP00254
(show subtarget assignments)

1

in_pdb
3P54

Yes

13272205

Japanese encephalitis virus Envelope pro...

406

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3P54

98.3%

Japanese encephalitis

IDP00117
(show subtarget assignments)

1

purified

No

NT01ST0298

16763632

yaeB

putative regulatory protein

235

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1XQB

47.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00253
(show subtarget assignments)

1

in_crystallization_trials

No

YFVgp1

9627245

Yellow fever virus Envelope protein

399

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1P58

43.8%

Yellow fever

IDP00029
(show subtarget assignments)

1

purified

No

BA_0404

30253939

tellurite resistance protein, putative

360

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00252
(show subtarget assignments)

1

in_crystallization_trials

No

130516

St. Louis encephalitis virus Envelope pr...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

2I69

70.5%

St. Louis

IDP00116
(show subtarget assignments)

0

work_stopped

No

NT01ST0285

16763622

accA

acetylCoA carboxylase, carboxytransferas...

319

Essential

Phase 1: October 2007

2F9Y

96.9%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00058
(show subtarget assignments)

1

soluble

No

BA_3903

30258417

bacteriocin ABC transporter, ATP-binding...

234

Virulence

Phase 1: October 2007

1OXS

32.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00251
(show subtarget assignments)

1

cloned

No

MVEVgp1

9633623

Murray Valley encephalitis Envelope prot...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3P54

78.1%

Murray Valley

IDP00233
(show subtarget assignments)

1

cloned

No

YPO3676

16123819

-

putative phage-related protein

133

Virulence

Phase 1: October 2007

2VO9

25.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00115
(show subtarget assignments)

1

crystallized

No

NT01VPA0514

28900406

VPA0551

hypothetical protein VPA0551 (gi 2890040...

181

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2OT9

33.7%

Vibrio parahaemolyticus

Cellular processes

Toxin production and resistance

IDP00232
(show subtarget assignments)

1

cloned

No

YPO3480

16123626

-

conserved hypothetical protein

292

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00231
(show subtarget assignments)

1

soluble

No

YPO3479

16123625

-

putative protease

331

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00114
(show subtarget assignments)

1

purified

No

GVCV52ORF0478

9654887

Vibrio cholerae O1 biovar eltor str. N16...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3JVU

65.8%

Vibrio cholerae

Cell envelope

Surface structures

IDP00057
(show subtarget assignments)

1

soluble

No

BA_3900

30258414

lantibiotic biosynthesis DNA-binding res...

220

Virulence

Phase 1: October 2007

2GWR

34.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00230
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3444

16123592

-

putative acetyltransferase

167

Virulence

Phase 1: October 2007

2GE3

18%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00229
(show subtarget assignments)

1

soluble

No

YPO0417

16120750

-

putative O-antigen biosynthesis protein

410

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00113
(show subtarget assignments)

0

work_stopped

No

NT01SAA0015

16119212

blaI

PENICILLINASE REPRESSOR

126

Virulence

Phase 1: October 2007

1SD4

100%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00228
(show subtarget assignments)

1

cloned

No

YPO3388

16123537

-

putative chloride channel protein

441

Virulence

Phase 1: October 2007

1KPL

76.6%

Yersinia pestis

Transcription

Transcription factors

IDP00028
(show subtarget assignments)

1

purified

No

BA_0401

30253936

tellurium resistance protein

194

Virulence

Phase 1: October 2007

2KXT

57.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00014
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3915

17368674

Protein recA (Recombinase A)

343

Drug Target Homolog

Phase 1: October 2007

1UBC

65.6%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP00227
(show subtarget assignments)

1

expressed

No

YPO3249

16123408

-

putative amino acid hydrolase

430

Virulence

Phase 1: October 2007

3N5F

36%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00112
(show subtarget assignments)

1

soluble

No

NT01SF5194

30043810

hflK

protease specific for phage lambda cII r...

419

Essential

Phase 1: October 2007

3BK6

11%

Shigella flexneri

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00056
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3898

30258412

choloylglycine hydrolase family protein ...

328

Virulence

Phase 1: October 2007

2OQC

48.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00226
(show subtarget assignments)

1

soluble

No

YPO3938

16124066

glgP

glycogen phosphorylase

815

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 1: October 2007

1EM6

49.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00225
(show subtarget assignments)

1

cloned

No

YPO3069

16123246

-

putative exported protein

486

Virulence

Phase 1: October 2007

3C37

15%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP00111
(show subtarget assignments)

1

in_pdb
3TV9

No

NT02SF4808

30043741

pmbA

putative peptide maturation protein

450

Virulence

Phase 1: October 2007

3TV9

96.2%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00224
(show subtarget assignments)

1

cloned

No

YPO3058

16123235

-

putative membrane protein

288

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00223
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3054

16123231

-

putative carboxypeptidase

225

Virulence

Phase 1: October 2007

Yersinia pestis

IDP00110
(show subtarget assignments)

1

purified

No

NT01SF4145

30043548

glgC

glucose-1-phosphate adenylyltransferase ...

431

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3BRK

55.2%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00055
(show subtarget assignments)

0

work_stopped

No

BA_3696

30258217

blasticidin S deaminase, putative

142

Virulence

Phase 1: October 2007

3B8F

99.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00222
(show subtarget assignments)

1

cloned

No

YPO3049

16123226

-

putative binding protein-dependent trans...

589

Virulence

Phase 1: October 2007

3DKN

15.3%

Yersinia pestis

IDP00221
(show subtarget assignments)

1

soluble

No

YPO0164

16120507

-

putative membrane receptor protein

686

Virulence

Phase 1: October 2007

2HDF

20.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00109
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF4517

30043269

recF

Rec protein

357

Essential

Phase 1: October 2007

2O5V

27.2%

Shigella flexneri

DNA metabolism

DNA replication, recombination, and repair

IDP00220
(show subtarget assignments)

1

purified

No

YPO2855

16123048

-

putative protease

464

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00027
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0400

30253935

tellurium resistance protein

194

Virulence

Phase 1: October 2007

2KXT

56.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00219
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1938

16122184

-

probable deoR-family transcriptional reg...

256

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00108
(show subtarget assignments)

1

purified

No

NT01SF4751

30043076

fdhE

FdhE protein

309

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FIY

39.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00054
(show subtarget assignments)

1

crystallized

No

BA_3600

30258128

acetyltransferase, CYSE/LACA/LPXA/NODL f...

185

Virulence

Phase 1: October 2007

1KHR

42.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00218
(show subtarget assignments)

1

expressed

No

YPO2340

16122564

-

conserved hypothetical protein

256

Virulence

Phase 1: October 2007

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP00217
(show subtarget assignments)

1

cloned

No

YPO2319

16122543

-

putative pepetidase

278

Virulence

Phase 1: October 2007

1AGJ

24.1%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00107
(show subtarget assignments)

1

in_pdb
3DR3

No

NT01SF4834

30043015

argC

N-acetyl-gamma-glutamylphosphate reducta...

334

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DR3

100%

Shigella flexneri

Amino acid biosynthesis

Glutamate family

IDP00216
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2310

16122534

-

putative carboxypeptidase

499

Virulence

Phase 1: October 2007

3DWC

48.1%

Yersinia pestis

Regulatory functions

Other

IDP00215
(show subtarget assignments)

1

cloned

No

YPO2295

16122519

-

haloacid dehalogenase-like hydrolase fam...

224

Virulence

Phase 1: October 2007

3ED5

31.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00106
(show subtarget assignments)

0

work_stopped

No

NT01SF3707

30042635

mdaB

modulator of drug activity B

193

Virulence

Phase 1: October 2007

2AMJ

97.9%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00053
(show subtarget assignments)

1

soluble

No

BA_3536

30258071

phenazine biosynthesis protein, PhzF fam...

285

Virulence

Phase 1: October 2007

1QY9

31.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00214
(show subtarget assignments)

1

expressed

No

YPO2252

16122476

-

putative toxin transport protein

712

Virulence

Phase 1: October 2007

2YL4

26.1%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00213
(show subtarget assignments)

1

soluble

No

YPO0628

16120954

-

putative translational inhibitor protein...

134

Virulence

Phase 1: October 2007

3I7T

35.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00105
(show subtarget assignments)

1

purified

No

NT01SF3662

30042589

S3225

putative class II aminotransferase

116

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2X8U

40.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP00212
(show subtarget assignments)

1

expressed

No

YPO2123

16122358

-

putative phage minor tail protein

236

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00026
(show subtarget assignments)

1

soluble

No

BA_0399

30253934

tellurium resistance protein, putative

198

Virulence

Phase 1: October 2007

3IBZ

41.9%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00013
(show subtarget assignments)

1

soluble

No

BA_3254

30257811

LPXTG-motif cell wall anchor domain prot...

372

Drug Target Homolog

Phase 1: October 2007

1I84

18.3%

Bacillus anthracis

Cell envelope

Other

IDP00211
(show subtarget assignments)

1

purified

No

YPO2101

16122340

-

hypothetical phage protein

211

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00104
(show subtarget assignments)

1

purified

No

NT01SF3305

30042319

srlB

PTS system, glucitol/sorbitol-specific e...

123

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2F9H

25.2%

Shigella flexneri

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00052
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3500

30258038

bla2

beta-lactamase II

256

Virulence

Phase 1: October 2007

1BC2

81.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00210
(show subtarget assignments)

1

crystallized

No

YPO0314

16120652

lexA

LexA repressor

202

Virulence

Phase 1: October 2007

1JHF

91.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00209
(show subtarget assignments)

1

soluble

No

YPO2062

16122301

-

putative M23/M37 peptidase-family protei...

417

Virulence

Phase 1: October 2007

2GU1

32.4%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP00103
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF3270

30042295

ygaC

hypothetical protein S2885

114

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2G7J

86.8%

Shigella flexneri

Cell envelope

Other

IDP00208
(show subtarget assignments)

1

expressed

No

YPO1979

16122221

-

putative dehydrogenase

338

Virulence

Phase 1: October 2007

2PK3

21.3%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00207
(show subtarget assignments)

1

soluble

No

YPO1950

16122196

-

putative peptidase

405

Virulence

Phase 1: October 2007

1WN1

23.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00102
(show subtarget assignments)

1

crystallized

No

NT01SF2944

30042031

evgA

putative positive transcription regulato...

204

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3F6C

64.7%

Shigella flexneri

Cell envelope

Surface structures

IDP00051
(show subtarget assignments)

1

in_pdb
3EDN

Yes

BA_3469

30258008

phenazine biosynthesis protein, PhzF fam...

299

Virulence

Phase 1: October 2007

3EDN

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00206
(show subtarget assignments)

1

soluble

No

YPO1706

16121966

-

putative heat shock protein

293

Virulence

Phase 1: October 2007

3CQB

28.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00205
(show subtarget assignments)

1

cloned

No

YPO1705

16121965

-

tail-specific protease precursor

690

Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...

Phase 1: October 2007

1FC6

15.8%

Yersinia pestis

IDP00101
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF2638

30041803

mrp

putative ATPase

369

Essential

Phase 1: October 2007

2PH1

27.1%

Shigella flexneri

Unknown function

General

Targets