Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00844 (show subtarget assignments)	1	diffraction	No	SACOL0519	57285544		acetyltransferase, GNAT family	174	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP01493 (show subtarget assignments)	1	diffraction	No	VCA0751	161582040		3-oxoacyl-(acyl carrier protein) synthas...	362	Drug Target Function	Phase 2: March 2008	2EBD	40.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00739 (show subtarget assignments)	1	diffraction	No	SACOL1063	57284433		acetyltransferase, GNAT family	144	Drug Target Function	Phase 2: March 2008	1Q2Y	40.3%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP90551 (show subtarget assignments)	8	diffraction	No	VC0875	15640891		prolyl-tRNA synthetase [Vibrio cholerae ...	571	Predicted Essential	Community Requests	2J3L	45.5%	Vibrio cholerae

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP02646 (show subtarget assignments)	1	expressed	No	CBU_1290	29541858	dnaK	chaperone protein dnak [Coxiella burneti...	656	Conserved; Drug target functions	Phase 3: June 2008	2KHO	68.9%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP05613 (show subtarget assignments)	1	expressed	No	BA_5436	30259904		putative polysaccharide deacetylase [Bac...	245	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	29%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00585 (show subtarget assignments)	1	expressed	No	YPO0116	16120461	metL	bifunctional aspartate kinase II/homoser...	811	Virulence Associated Factor	Phase 2: March 2008	1EBF	15.5%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02650 (show subtarget assignments)	1	expressed	No	YPO3962	16124090		sugar-binding transport protein [Yersini...	314	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	34.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00583 (show subtarget assignments)	1	expressed	No	YPO2752	16122956	mepA	penicillin-insensitive murein endopeptid...	275	Drug Target Function	Phase 2: March 2008	1TZP	67.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01116 (show subtarget assignments)	1	expressed	No	BA_1693	30255984		glycosyl transferase, group 2 family pro...	150	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04285 (show subtarget assignments)	1	expressed	No	YPO0809	218927989		general secretion pathway protein K [Yer...	318	putative drug target function;	Phase 4: April 2009	3CI0	18.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP05611 (show subtarget assignments)	1	expressed	No	BA_5156	30259642		conserved hypothetical protein [Bacillus...	208	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05609 (show subtarget assignments)	1	expressed	No	BA_5054	30259543		putative S-layer protein [Bacillus anthr...	268	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	19%	Bacillus anthracis	Cell envelope: Surface structures

IDP05604 (show subtarget assignments)	1	expressed	No	BA_4769	30259256		putative spore coat protein C [Bacillus ...	110	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Sporulation and germination

IDP02636 (show subtarget assignments)	1	expressed	No	YPO3722	16123860	metH	B12-dependent methionine synthase [Yersi...	1231	CD; Drug target functions	Phase 3: June 2008	1K7Y	40.1%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02631 (show subtarget assignments)	1	expressed	No	GBAA1440	47526715	cysH	phosphoadenosine phosphosulfate reductas...	226	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GOY	37.6%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP02223 (show subtarget assignments)	1	expressed	No	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02673 (show subtarget assignments)	1	expressed	No	STM4466	16767711		carbamate kinase [Salmonella typhimurium...	310	Conserved; Drug target functions	Phase 3: June 2008	1E19	45.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP01101 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0119	47566439		hypothetical protein GBAA_pXO1_0119	82	Virulence Associated Factor	Phase 2: March 2008	3SIK	52.4%	Bacillus anthracis

IDP02218 (show subtarget assignments)	1	expressed	No	GBAA2133	47778008	narA-1	molybdenum cofactor biosynthesis protein...	337	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TV7	54.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP04272 (show subtarget assignments)	1	expressed	No	GBAA3899	47529188		lantibiotic biosynthesis sensor histidin...	453	putative drug target function;	Phase 4: April 2009	2C2A	14.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP05586 (show subtarget assignments)	1	expressed	No	BA_2746	30257351		putative lipoprotein [Bacillus anthracis...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP02213 (show subtarget assignments)	1	expressed	No	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP05570 (show subtarget assignments)	1	expressed	No	BAS5100	49188086	-	hypothetical protein BAS5100 [Bacillus a...	132	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP02207 (show subtarget assignments)	1	expressed	No	YPO0612	16120938		putative sugar binding protein [Yersinia...	414	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QUF	24.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01088 (show subtarget assignments)	1	expressed	No	STM4512	16767756	iadA	isoaspartyl dipeptidase	390	Drug Target Function	Phase 2: March 2008	1ONX	81%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP02199 (show subtarget assignments)	1	expressed	No	CBU_1505	29542064	lepA	GTP-binding protein LepA [Coxiella burne...	614	Conserved; Drug target functions	Phase 3: June 2008	3CB4	69.9%	Coxiella burnetii	Unknown function	General

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02194 (show subtarget assignments)	1	expressed	No	FTT0075	56707254	sdhB	succinate dehydrogenase iron-sulfur subu...	233	Conserved; Drug target functions	Phase 3: June 2008	1NEK	66.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP01082 (show subtarget assignments)	1	expressed	No	STM4279	16767529	nrfC	putative formate-dependent nitrite reduc...	223	Essential Gene	Phase 2: March 2008	2VPW	35.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP02312 (show subtarget assignments)	1	expressed	No	GBAA2190	47778017		FtsK/SpoIIIE family protein [Bacillus an...	1342	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IUT	7.4%	Bacillus anthracis	Cellular processes	Cell division

IDP02188 (show subtarget assignments)	1	expressed	No	YPO0267	16120605		type III secretion system ATPase [Yersin...	445	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008	2DPY	43.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05557 (show subtarget assignments)	1	expressed	No	lmo1459	16803499	glyQ	glycyl-tRNA synthetase subunit alpha [Li...	263	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1J5W	54.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP02184 (show subtarget assignments)	1	expressed	No	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP01076 (show subtarget assignments)	8	expressed	No	STM4120	16767385	argE	acetylornithine deacetylase	383	Drug Target Function	Community Requests	3CT9	25.1%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP02617 (show subtarget assignments)	1	expressed	No	GBAA1286	47526551		D-alanyl-D-alanine carboxypeptidase fami...	428	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3MFD	24.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02173 (show subtarget assignments)	1	expressed	No	Cj1136	15792461		putative galactosyltransferase [Campylob...	390	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	20.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00264 (show subtarget assignments)	1	expressed	No	NP_056776_2244-2491	159024209	N/A	NS4B	248	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP01070 (show subtarget assignments)	1	expressed	No	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP02613 (show subtarget assignments)	1	expressed	No	YPO3530	16123676	cpdB	bifunctional 2',3'-cyclic nucleotide 2'-...	656	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3JYF	40.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02615 (show subtarget assignments)	1	expressed	No	GBAA4677	47529976		ribonuclease [Bacillus anthracis str. 'A...	458	Conserved; Drug target functions	Phase 3: June 2008	2BX2	27.7%	Bacillus anthracis	Cellular processes	Cell division

IDP02168 (show subtarget assignments)	1	expressed	No	CBU_1289	29541857	dnaJ	chaperone protein dnaJ [Coxiella burneti...	374	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	32.1%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02167 (show subtarget assignments)	1	expressed	No	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01067 (show subtarget assignments)	1	expressed	No	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP02610 (show subtarget assignments)	1	expressed	No	Cj1417c	15792735		hypothetical protein Cj1417c [Campylobac...	200	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1GEE	87.7%	Campylobacter jejuni	Cell envelope	Other

IDP02630 (show subtarget assignments)	1	expressed	No	STM2899	16766205	invF	invasion regulatory protein [Salmonella ...	216	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP01066 (show subtarget assignments)	1	expressed	No	STM3819	16767104	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP01065 (show subtarget assignments)	1	expressed	No	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04288 (show subtarget assignments)	1	expressed	No	YPCD1.08c	5832431	YPCD1.08c	hypothetical protein YPCD1.08c [Yersinia...	99	virulence factor; conserved gene;	Phase 4: April 2009	3KXE	28.3%	Yersinia pestis

IDP02157 (show subtarget assignments)	1	expressed	No	GBAA3961	47778228	uppS	undecaprenyl diphosphate synthase [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1F75	55.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00120 (show subtarget assignments)	1	expressed	No	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP02608 (show subtarget assignments)	1	expressed	No	CBU_0178	29540794		ABC transporter, ATP-binding protein [Co...	252	Conserved; Drug target functions	Phase 3: June 2008	1V43	43.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02154 (show subtarget assignments)	1	expressed	No	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04271 (show subtarget assignments)	1	expressed	No	CPF_2241	110798635		sensor histidine kinase [Clostridium per...	678	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	12.4%	Clostridium perfringens	Signal transduction	Two-component systems

IDP02190 (show subtarget assignments)	1	expressed	No	YPO0360	16120695	frdA	fumarate reductase flavoprotein subunit ...	607	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1KF6	85.2%	Yersinia pestis	Energy metabolism	Anaerobic

IDP02191 (show subtarget assignments)	1	expressed	No	FTT0878c	56707982	msrB	methionine sulfoxide reductase B [Franci...	170	Drug Target	Phase 3: June 2008	1XM0	47.6%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP02153 (show subtarget assignments)	1	expressed	No	CBU_0884	29541475	bipA	virulence regulator BipA [Coxiella burne...	602	Conserved; Drug target functions	Phase 3: June 2008	3E3X	34.6%	Coxiella burnetii	Cellular processes	Pathogenesis

IDP04566 (show subtarget assignments)	1	expressed	No	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP05550 (show subtarget assignments)	1	expressed	No	lmo0481	16802524	-	hypothetical protein lmo0481 [Listeria m...	566	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02195 (show subtarget assignments)	1	expressed	No	FTT0084c	56707262	hemN	oxygen-independent coproporphyrinogen II...	380	Conserved; Drug target functions	Phase 3: June 2008	1OLT	22.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02143 (show subtarget assignments)	1	expressed	No	CBU_0739	29541339	clpX	ATP-dependent Clp protease, ATP-binding ...	422	Conserved; Drug target functions	Phase 3: June 2008	3HTE	59.5%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04249 (show subtarget assignments)	1	expressed	No	CPF_1548	110800969		putative galactoside ABC transporter, ga...	354	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GLG	50.6%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02138 (show subtarget assignments)	1	expressed	No	Cj0580c	15791940		coproporphyrinogen III oxidase [Campylob...	355	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	22.5%	Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP02603 (show subtarget assignments)	1	expressed	No	GBAA4274	47529567	nagA	N-acetylglucosamine-6-phosphate deacetyl...	380	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VHL	44%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP02604 (show subtarget assignments)	1	expressed	No	CBU_1893	29542450	aroB	3-dehydroquinate synthase [Coxiella burn...	360	Conserved; Drug target functions	Phase 3: June 2008	3OKF	48.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01052 (show subtarget assignments)	1	expressed	No	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02133 (show subtarget assignments)	1	expressed	No	YPO0054	16120407	kdtX	lipopolysaccharide core biosynthesis gly...	260	Drug target motif; Involved in virulence; Drug target functions	Phase 3: June 2008	3E25	11.5%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01051 (show subtarget assignments)	1	expressed	No	STM3219	16766518	fadH	2,4-dieonyl-CoA reductase	672	Drug Target Function	Phase 2: March 2008	1PS9	85.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP02129 (show subtarget assignments)	1	expressed	No	CBU_0450	29541057	ffh	signal recognition particle protein [Cox...	461	Conserved; Drug target functions	Phase 3: June 2008	2XXA	57.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP00553 (show subtarget assignments)	1	expressed	No	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP01046 (show subtarget assignments)	1	expressed	No	STM3138	16766438		putative methyl-accepting chemotaxis pro...	352	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	16.8%	Salmonella enterica	Cellular processes	Other

IDP02120 (show subtarget assignments)	1	expressed	No	YPO0027	16120380		phosphatase [Yersinia pestis CO92]	196	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2B0C	66.8%	Yersinia pestis	Unknown function	General

IDP02600 (show subtarget assignments)	1	expressed	No	STM2279	16765606	yfaE	2Fe-2S ferredoxin YfaE [Salmonella typhi...	84	Conserved; Drug target functions	Phase 3: June 2008	1IUE	37.2%	Salmonella enterica	Unknown function	General

IDP04247 (show subtarget assignments)	1	expressed	No	CPF_1402	110798994		sensor histidine kinase [Clostridium per...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.3%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04236 (show subtarget assignments)	1	expressed	No	CPF_0837	110799475		sensor histidine kinase [Clostridium per...	336	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP01040 (show subtarget assignments)	1	expressed	No	STM2935	16766241	cysD	sulfate adenylyltransferase subunit 2	302	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	75.2%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP02110 (show subtarget assignments)	1	expressed	No	STM3820	16767105		putative cytochrome c peroxidase [Salmon...	466	Conserved; Drug target functions	Phase 3: June 2008	1IQC	29.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01039 (show subtarget assignments)	1	expressed	No	STM2934	16766240	cysN	sulfate adenylyltransferase subunit 1	479	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	52.4%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP04542 (show subtarget assignments)	1	expressed	No	YPO2000	218929110		putative two-component system sensor pro...	463	putative drug target function;	Phase 4: April 2009	3JZ3	13.2%	Yersinia pestis	Regulatory functions	Other

IDP05509 (show subtarget assignments)	1	expressed	No	BA_5736	30260182	spoIIIJ2	stage III sporulation protein J [Bacillu...	255	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Sporulation and germination

IDP02597 (show subtarget assignments)	1	expressed	No	YPO3472	16123618		putative sugar binding protein [Yersinia...	437	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1EU8	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00547 (show subtarget assignments)	1	expressed	No	YPO3813	16123947	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	39.6%	Yersinia pestis	Cellular processes	Cell division

IDP02103 (show subtarget assignments)	1	expressed	No	YPO0891	16121196	dsbC	thiol:disulfide interchange protein DsbC...	238	Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...	Phase 3: June 2008	1JZD	61.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02101 (show subtarget assignments)	1	expressed	No	STM3638	16766924	lpfC	long polar fimbrial outer membrane usher...	842	Conserved; Drug target functions	Phase 3: June 2008	3RFZ	44.8%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00546 (show subtarget assignments)	1	expressed	No	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP04543 (show subtarget assignments)	1	expressed	No	VC2453	9657030		sensor histidine kinase/response regulat...	927	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	8.1%	Vibrio cholerae	Regulatory functions	Other

IDP02308 (show subtarget assignments)	1	expressed	No	FTT1400c	56708448		hypothetical protein FTT1400c [Francisel...	128	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02593 (show subtarget assignments)	1	expressed	No	YPO3426	16123575	hofB	hypothetical protein YPO3426 [Yersinia p...	512	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	34.2%	Yersinia pestis	Cell envelope	Surface structures

IDP02607 (show subtarget assignments)	1	expressed	No	CBU_0101	29540723	nadB	L-aspartate oxidase [Coxiella burnetii R...	536	Conserved; Drug target functions	Phase 3: June 2008	1CHU	52.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02091 (show subtarget assignments)	1	expressed	No	STM3515	16766803	malT	transcriptional regulator MalT [Salmonel...	901	Conserved; Drug target functions	Phase 3: June 2008	1HZ4	36.6%	Salmonella enterica	Energy metabolism	Other

IDP04227 (show subtarget assignments)	1	expressed	No	CPF_0198	110799765		sensory box histidine kinase [Clostridiu...	791	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.6%	Clostridium perfringens	Regulatory functions

IDP02079 (show subtarget assignments)	1	expressed	No	Cj0173c	15791560		iron ABC transporter, ATP binding subuni...	302	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2D62	35.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02078 (show subtarget assignments)	1	expressed	No	YPO0268	16120606		type III secretion system apparatus prot...	133	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00844
(show subtarget assignments)

1

diffraction

No

SACOL0519

57285544

acetyltransferase, GNAT family

174

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP01493
(show subtarget assignments)

1

diffraction

No

VCA0751

161582040

3-oxoacyl-(acyl carrier protein) synthas...

362

Drug Target Function

Phase 2: March 2008

2EBD

40.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00739
(show subtarget assignments)

1

diffraction

No

SACOL1063

57284433

acetyltransferase, GNAT family

144

Drug Target Function

Phase 2: March 2008

1Q2Y

40.3%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP90551
(show subtarget assignments)

8

diffraction

No

VC0875

15640891

prolyl-tRNA synthetase [Vibrio cholerae ...

571

Predicted Essential

Community Requests

2J3L

45.5%

Vibrio cholerae

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP02646
(show subtarget assignments)

1

expressed

No

CBU_1290

29541858

dnaK

chaperone protein dnak [Coxiella burneti...

656

Conserved; Drug target functions

Phase 3: June 2008

2KHO

68.9%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP05613
(show subtarget assignments)

1

expressed

No

BA_5436

30259904

putative polysaccharide deacetylase [Bac...

245

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

29%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00585
(show subtarget assignments)

1

expressed

No

YPO0116

16120461

metL

bifunctional aspartate kinase II/homoser...

811

Virulence Associated Factor

Phase 2: March 2008

1EBF

15.5%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02650
(show subtarget assignments)

1

expressed

No

YPO3962

16124090

sugar-binding transport protein [Yersini...

314

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

34.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00583
(show subtarget assignments)

1

expressed

No

YPO2752

16122956

mepA

penicillin-insensitive murein endopeptid...

275

Drug Target Function

Phase 2: March 2008

1TZP

67.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01116
(show subtarget assignments)

1

expressed

No

BA_1693

30255984

glycosyl transferase, group 2 family pro...

150

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04285
(show subtarget assignments)

1

expressed

No

YPO0809

218927989

general secretion pathway protein K [Yer...

318

putative drug target function;

Phase 4: April 2009

3CI0

18.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP05611
(show subtarget assignments)

1

expressed

No

BA_5156

30259642

conserved hypothetical protein [Bacillus...

208

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05609
(show subtarget assignments)

1

expressed

No

BA_5054

30259543

putative S-layer protein [Bacillus anthr...

268

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

19%

Bacillus anthracis

Cell envelope: Surface structures

IDP05604
(show subtarget assignments)

1

expressed

No

BA_4769

30259256

putative spore coat protein C [Bacillus ...

110

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP02636
(show subtarget assignments)

1

expressed

No

YPO3722

16123860

metH

B12-dependent methionine synthase [Yersi...

1231

CD; Drug target functions

Phase 3: June 2008

1K7Y

40.1%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02631
(show subtarget assignments)

1

expressed

No

GBAA1440

47526715

cysH

phosphoadenosine phosphosulfate reductas...

226

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GOY

37.6%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP02223
(show subtarget assignments)

1

expressed

No

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02673
(show subtarget assignments)

1

expressed

No

STM4466

16767711

carbamate kinase [Salmonella typhimurium...

310

Conserved; Drug target functions

Phase 3: June 2008

1E19

45.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP01101
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0119

47566439

hypothetical protein GBAA_pXO1_0119

82

Virulence Associated Factor

Phase 2: March 2008

3SIK

52.4%

Bacillus anthracis

IDP02218
(show subtarget assignments)

1

expressed

No

GBAA2133

47778008

narA-1

molybdenum cofactor biosynthesis protein...

337

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TV7

54.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP04272
(show subtarget assignments)

1

expressed

No

GBAA3899

47529188

lantibiotic biosynthesis sensor histidin...

453

putative drug target function;

Phase 4: April 2009

2C2A

14.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP05586
(show subtarget assignments)

1

expressed

No

BA_2746

30257351

putative lipoprotein [Bacillus anthracis...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP02213
(show subtarget assignments)

1

expressed

No

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP05570
(show subtarget assignments)

1

expressed

No

BAS5100

49188086

-

hypothetical protein BAS5100 [Bacillus a...

132

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP02207
(show subtarget assignments)

1

expressed

No

YPO0612

16120938

putative sugar binding protein [Yersinia...

414

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QUF

24.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01088
(show subtarget assignments)

1

expressed

No

STM4512

16767756

iadA

isoaspartyl dipeptidase

390

Drug Target Function

Phase 2: March 2008

1ONX

81%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP02199
(show subtarget assignments)

1

expressed

No

CBU_1505

29542064

lepA

GTP-binding protein LepA [Coxiella burne...

614

Conserved; Drug target functions

Phase 3: June 2008

3CB4

69.9%

Coxiella burnetii

Unknown function

General

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02194
(show subtarget assignments)

1

expressed

No

FTT0075

56707254

sdhB

succinate dehydrogenase iron-sulfur subu...

233

Conserved; Drug target functions

Phase 3: June 2008

1NEK

66.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP01082
(show subtarget assignments)

1

expressed

No

STM4279

16767529

nrfC

putative formate-dependent nitrite reduc...

223

Essential Gene

Phase 2: March 2008

2VPW

35.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP02312
(show subtarget assignments)

1

expressed

No

GBAA2190

47778017

FtsK/SpoIIIE family protein [Bacillus an...

1342

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IUT

7.4%

Bacillus anthracis

Cellular processes

Cell division

IDP02188
(show subtarget assignments)

1

expressed

No

YPO0267

16120605

type III secretion system ATPase [Yersin...

445

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

2DPY

43.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05557
(show subtarget assignments)

1

expressed

No

lmo1459

16803499

glyQ

glycyl-tRNA synthetase subunit alpha [Li...

263

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1J5W

54.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP02184
(show subtarget assignments)

1

expressed

No

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division

IDP01076
(show subtarget assignments)

8

expressed

No

STM4120

16767385

argE

acetylornithine deacetylase

383

Drug Target Function

Community Requests

3CT9

25.1%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP02617
(show subtarget assignments)

1

expressed

No

GBAA1286

47526551

D-alanyl-D-alanine carboxypeptidase fami...

428

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3MFD

24.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02173
(show subtarget assignments)

1

expressed

No

Cj1136

15792461

putative galactosyltransferase [Campylob...

390

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

20.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00264
(show subtarget assignments)

1

expressed

No

NP_056776_2244-2491

159024209

N/A

NS4B

248

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP01070
(show subtarget assignments)

1

expressed

No

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP02613
(show subtarget assignments)

1

expressed

No

YPO3530

16123676

cpdB

bifunctional 2',3'-cyclic nucleotide 2'-...

656

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3JYF

40.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02615
(show subtarget assignments)

1

expressed

No

GBAA4677

47529976

ribonuclease [Bacillus anthracis str. 'A...

458

Conserved; Drug target functions

Phase 3: June 2008

2BX2

27.7%

Bacillus anthracis

Cellular processes

Cell division

IDP02168
(show subtarget assignments)

1

expressed

No

CBU_1289

29541857

dnaJ

chaperone protein dnaJ [Coxiella burneti...

374

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

32.1%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02167
(show subtarget assignments)

1

expressed

No

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01067
(show subtarget assignments)

1

expressed

No

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP02610
(show subtarget assignments)

1

expressed

No

Cj1417c

15792735

hypothetical protein Cj1417c [Campylobac...

200

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1GEE

87.7%

Campylobacter jejuni

Cell envelope

Other

IDP02630
(show subtarget assignments)

1

expressed

No

STM2899

16766205

invF

invasion regulatory protein [Salmonella ...

216

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01066
(show subtarget assignments)

1

expressed

No

STM3819

16767104

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP01065
(show subtarget assignments)

1

expressed

No

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04288
(show subtarget assignments)

1

expressed

No

YPCD1.08c

5832431

YPCD1.08c

hypothetical protein YPCD1.08c [Yersinia...

99

virulence factor; conserved gene;

Phase 4: April 2009

3KXE

28.3%

Yersinia pestis

IDP02157
(show subtarget assignments)

1

expressed

No

GBAA3961

47778228

uppS

undecaprenyl diphosphate synthase [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1F75

55.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00120
(show subtarget assignments)

1

expressed

No

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP02608
(show subtarget assignments)

1

expressed

No

CBU_0178

29540794

ABC transporter, ATP-binding protein [Co...

252

Conserved; Drug target functions

Phase 3: June 2008

1V43

43.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02154
(show subtarget assignments)

1

expressed

No

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04271
(show subtarget assignments)

1

expressed

No

CPF_2241

110798635

sensor histidine kinase [Clostridium per...

678

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

12.4%

Clostridium perfringens

Signal transduction

Two-component systems

IDP02190
(show subtarget assignments)

1

expressed

No

YPO0360

16120695

frdA

fumarate reductase flavoprotein subunit ...

607

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1KF6

85.2%

Yersinia pestis

Energy metabolism

Anaerobic

IDP02191
(show subtarget assignments)

1

expressed

No

FTT0878c

56707982

msrB

methionine sulfoxide reductase B [Franci...

170

Drug Target

Phase 3: June 2008

1XM0

47.6%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP02153
(show subtarget assignments)

1

expressed

No

CBU_0884

29541475

bipA

virulence regulator BipA [Coxiella burne...

602

Conserved; Drug target functions

Phase 3: June 2008

3E3X

34.6%

Coxiella burnetii

Cellular processes

Pathogenesis

IDP04566
(show subtarget assignments)

1

expressed

No

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP05550
(show subtarget assignments)

1

expressed

No

lmo0481

16802524

-

hypothetical protein lmo0481 [Listeria m...

566

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02195
(show subtarget assignments)

1

expressed

No

FTT0084c

56707262

hemN

oxygen-independent coproporphyrinogen II...

380

Conserved; Drug target functions

Phase 3: June 2008

1OLT

22.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02143
(show subtarget assignments)

1

expressed

No

CBU_0739

29541339

clpX

ATP-dependent Clp protease, ATP-binding ...

422

Conserved; Drug target functions

Phase 3: June 2008

3HTE

59.5%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04249
(show subtarget assignments)

1

expressed

No

CPF_1548

110800969

putative galactoside ABC transporter, ga...

354

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GLG

50.6%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02138
(show subtarget assignments)

1

expressed

No

Cj0580c

15791940

coproporphyrinogen III oxidase [Campylob...

355

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

22.5%

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP02603
(show subtarget assignments)

1

expressed

No

GBAA4274

47529567

nagA

N-acetylglucosamine-6-phosphate deacetyl...

380

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VHL

44%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP02604
(show subtarget assignments)

1

expressed

No

CBU_1893

29542450

aroB

3-dehydroquinate synthase [Coxiella burn...

360

Conserved; Drug target functions

Phase 3: June 2008

3OKF

48.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01052
(show subtarget assignments)

1

expressed

No

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02133
(show subtarget assignments)

1

expressed

No

YPO0054

16120407

kdtX

lipopolysaccharide core biosynthesis gly...

260

Drug target motif; Involved in virulence; Drug target functions

Phase 3: June 2008

3E25

11.5%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01051
(show subtarget assignments)

1

expressed

No

STM3219

16766518

fadH

2,4-dieonyl-CoA reductase

672

Drug Target Function

Phase 2: March 2008

1PS9

85.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP02129
(show subtarget assignments)

1

expressed

No

CBU_0450

29541057

ffh

signal recognition particle protein [Cox...

461

Conserved; Drug target functions

Phase 3: June 2008

2XXA

57.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP00553
(show subtarget assignments)

1

expressed

No

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP01046
(show subtarget assignments)

1

expressed

No

STM3138

16766438

putative methyl-accepting chemotaxis pro...

352

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

16.8%

Salmonella enterica

Cellular processes

Other

IDP02120
(show subtarget assignments)

1

expressed

No

YPO0027

16120380

phosphatase [Yersinia pestis CO92]

196

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2B0C

66.8%

Yersinia pestis

Unknown function

General

IDP02600
(show subtarget assignments)

1

expressed

No

STM2279

16765606

yfaE

2Fe-2S ferredoxin YfaE [Salmonella typhi...

84

Conserved; Drug target functions

Phase 3: June 2008

1IUE

37.2%

Salmonella enterica

Unknown function

General

IDP04247
(show subtarget assignments)

1

expressed

No

CPF_1402

110798994

sensor histidine kinase [Clostridium per...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.3%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04236
(show subtarget assignments)

1

expressed

No

CPF_0837

110799475

sensor histidine kinase [Clostridium per...

336

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP01040
(show subtarget assignments)

1

expressed

No

STM2935

16766241

cysD

sulfate adenylyltransferase subunit 2

302

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

75.2%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP02110
(show subtarget assignments)

1

expressed

No

STM3820

16767105

putative cytochrome c peroxidase [Salmon...

466

Conserved; Drug target functions

Phase 3: June 2008

1IQC

29.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01039
(show subtarget assignments)

1

expressed

No

STM2934

16766240

cysN

sulfate adenylyltransferase subunit 1

479

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

52.4%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP04542
(show subtarget assignments)

1

expressed

No

YPO2000

218929110

putative two-component system sensor pro...

463

putative drug target function;

Phase 4: April 2009

3JZ3

13.2%

Yersinia pestis

Regulatory functions

Other

IDP05509
(show subtarget assignments)

1

expressed

No

BA_5736

30260182

spoIIIJ2

stage III sporulation protein J [Bacillu...

255

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP02597
(show subtarget assignments)

1

expressed

No

YPO3472

16123618

putative sugar binding protein [Yersinia...

437

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1EU8

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00547
(show subtarget assignments)

1

expressed

No

YPO3813

16123947

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

39.6%

Yersinia pestis

Cellular processes

Cell division

IDP02103
(show subtarget assignments)

1

expressed

No

YPO0891

16121196

dsbC

thiol:disulfide interchange protein DsbC...

238

Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...

Phase 3: June 2008

1JZD

61.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02101
(show subtarget assignments)

1

expressed

No

STM3638

16766924

lpfC

long polar fimbrial outer membrane usher...

842

Conserved; Drug target functions

Phase 3: June 2008

3RFZ

44.8%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00546
(show subtarget assignments)

1

expressed

No

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP04543
(show subtarget assignments)

1

expressed

No

VC2453

9657030

sensor histidine kinase/response regulat...

927

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

8.1%

Vibrio cholerae

Regulatory functions

Other

IDP02308
(show subtarget assignments)

1

expressed

No

FTT1400c

56708448

hypothetical protein FTT1400c [Francisel...

128

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02593
(show subtarget assignments)

1

expressed

No

YPO3426

16123575

hofB

hypothetical protein YPO3426 [Yersinia p...

512

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

34.2%

Yersinia pestis

Cell envelope

Surface structures

IDP02607
(show subtarget assignments)

1

expressed

No

CBU_0101

29540723

nadB

L-aspartate oxidase [Coxiella burnetii R...

536

Conserved; Drug target functions

Phase 3: June 2008

1CHU

52.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02091
(show subtarget assignments)

1

expressed

No

STM3515

16766803

malT

transcriptional regulator MalT [Salmonel...

901

Conserved; Drug target functions

Phase 3: June 2008

1HZ4

36.6%

Salmonella enterica

Energy metabolism

Other

IDP04227
(show subtarget assignments)

1

expressed

No

CPF_0198

110799765

sensory box histidine kinase [Clostridiu...

791

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.6%

Clostridium perfringens

Regulatory functions

IDP02079
(show subtarget assignments)

1

expressed

No

Cj0173c

15791560

iron ABC transporter, ATP binding subuni...

302

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2D62

35.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02078
(show subtarget assignments)

1

expressed

No

YPO0268

16120606

type III secretion system apparatus prot...

133

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

Targets