Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01675 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5217	47530523		ABC transporter ATP-binding protein [Bac...	261	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2D2E	57.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00127 (show subtarget assignments)	1	soluble	No	NT01ST1705	16764721	sufC	cysteine desulfurase ATPase component	248	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2D3W	92.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP02099 (show subtarget assignments)	1	cloned	No	FTT0972	56708065		ABC transporter, ATP-binding protein [Fr...	249	Conserved; Drug target functions	Phase 3: June 2008	2D3W	57.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02511 (show subtarget assignments)	1	soluble	No	CBU_1359	29541924	sufC	ABC transporter, ATP-binding protein [Co...	244	Conserved; Drug target functions	Phase 3: June 2008	2D3W	63.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00099 (show subtarget assignments)	0	work_stopped	No	NT02SF1983	30041448	ynhD	putative ATP-binding component of a tran...	248	Conserved; CD; Drug target functions	Phase 1: October 2007	2D3W	99.6%	Shigella flexneri	Transport and binding proteins	Unknown substrate

IDP00949 (show subtarget assignments)	1	purified	No	STM1102	16764460	hpaE	4-hydroxyphenylacetate catabolism	488	Conserved Gene / Pathway	Phase 2: March 2008	2D4E	47.7%	Salmonella enterica	Central intermediary metabolism	Other

IDP00953 (show subtarget assignments)	1	in_crystallization_trials	No	STM1183	16764539	flgK	flagellar hook-associated protein FlgK	553	Conserved Gene / Pathway	Phase 2: March 2008	2D4Y	83.5%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP01773 (show subtarget assignments)	1	soluble	No	Cj1466	15792783	flgK	flagellar hook-associated protein FlgK [...	608	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	2D4Y	18.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00070 (show subtarget assignments)	0	work_stopped	No	NT01ST1465	16419700	flgK	hook-filament junction protein 1	553	Virulence	Phase 1: October 2007	2D4Y	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP02079 (show subtarget assignments)	1	expressed	No	Cj0173c	15791560		iron ABC transporter, ATP binding subuni...	302	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2D62	35.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00760 (show subtarget assignments)	1	soluble	No	SACOL0192	57285394		maltose ABC transporter, ATP-binding pro...	365	Drug Target Function	Phase 2: March 2008	2D62	53.5%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01423 (show subtarget assignments)	1	purified	No	VC1552	15641560	ugpC	glycerol-3-phosphate ABC transporter, AT...	393	Conserved Gene / Pathway	Phase 2: March 2008	2D62	45.5%	Vibrio cholerae	Transport and binding proteins	Other

IDP00713 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1108	57285894		spermidine/putrescine ABC transporter, A...	364	Conserved Gene / Pathway	Phase 2: March 2008	2D62	40.4%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01336 (show subtarget assignments)	1	purified	No	VC1428	15641439	potA	putrescine/spermidine ABC transporter AT...	377	Conserved Gene / Pathway	Phase 2: March 2008	2D62	41.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00149 (show subtarget assignments)	1	expressed	No	VCA0230	15600999	vctC	vibriobactin and enterobactin ABC transp...	254	Virulence	Phase 1: October 2007	2D62	28%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02503 (show subtarget assignments)	1	cloned	No	YPO2502	16122723	gutB	putative zinc-binding dehydrogenase [Yer...	408	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	2D8A	30.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Chlorophyll and bacteriochlorphyll

IDP02277 (show subtarget assignments)	1	crystallized	No	GBAA1434	47526709		glycerate dehydrogenase [Bacillus anthra...	323	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2DBQ	48.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP00128 (show subtarget assignments)	1	soluble	No	NT01ST3027	16765755	pdxK	mp65f07.r1 Soares_thymus_2NbMT Mus muscu...	288	Essential	Phase 1: October 2007	2DDM	65.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP90692 (show subtarget assignments)	8	purified	No	YPO1638	16121906	trmU	tRNA (5-methylaminomethyl-2-thiouridylat...	371	Predicted Essential	Community Requests	2DER	85.7%	Yersinia pestis

IDP02706 (show subtarget assignments)	1	cloned	No	FTT0470	56707612	apaH	diadenosine tetraphosphatase [Francisell...	275	Drug Target	Phase 3: June 2008	2DFJ	37.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP00524 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0490	16120820	apaH	diadenosine tetraphosphatase	289	Conserved Gene / Pathway	Phase 2: March 2008	2DFJ	73.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP01322 (show subtarget assignments)	1	purified	No	VC2296	15642294		bolA protein	106	Conserved Gene / Pathway	Phase 2: March 2008	2DHM	50.9%	Vibrio cholerae	Cellular processes	Other

IDP02605 (show subtarget assignments)	1	cloned	No	YPO3502	16123648	hflB	ATP-dependent metalloprotease [Yersinia ...	644	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	2DHR	40.7%	Yersinia pestis	Cellular processes	Cell division

IDP02738 (show subtarget assignments)	1	cloned	No	FTT1310c	56708367	hflB	ATP-dependent metalloprotease [Francisel...	638	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2DHR	39.3%	Francisella tularensis	N/A	N/A

IDP91903 (show subtarget assignments)	8	selected	No	SpneCM_010100005798	298255108		hypothetical protein SpneCM_05798 [Strep...	663	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2DHR	40.7%	Streptococcus pneumoniae

IDP90975 (show subtarget assignments)	8	cloned	No	y0011	22123933		hypothetical protein y0011 [Yersinia pes...	229	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	2DI3	21.4%	Yersinia pestis

IDP92027 (show subtarget assignments)	8	selected	No	TGME49_017580	237844055		DNA-directed RNA polymerases III, 39 kDa...	325	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2DK5	9.2%	Toxoplasma gondii

IDP02708 (show subtarget assignments)	1	cloned	No	lmo0291	16802337		hypothetical protein lmo0291 [Listeria m...	276	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2DKF	13.4%	Listeria monocytogenes	Cellular processes	Toxin production and resistance

IDP91733 (show subtarget assignments)	8	selected	No	P88946_HHV8	0			449	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2DLL	6.9%	Human herpesvirus

IDP92080 (show subtarget assignments)	8	selected	No	TGME49_105290	237842049		vacuolar ATP synthase subunit E, putativ...	236	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2DM9	25%	Toxoplasma gondii

IDP02188 (show subtarget assignments)	1	expressed	No	YPO0267	16120605		type III secretion system ATPase [Yersin...	445	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008	2DPY	43.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP91477 (show subtarget assignments)	8	expressed	No	VPA1338	28901193		putative ATPase YscN [Vibrio parahaemoly...	420	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2DPY	34.5%	Vibrio parahaemolyticus

IDP02097 (show subtarget assignments)	1	cloned	No	Cj0195	15791582	fliI	flagellum-specific ATP synthase [Campylo...	461	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	2DPY	40.3%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP91506 (show subtarget assignments)	8	expressed	No	VP1668	28898442		type III secretion system ATPase [Vibrio...	440	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2DPY	44.1%	Vibrio parahaemolyticus

IDP00450 (show subtarget assignments)	1	cloned	No	YPCD1.40	16082728	yscN	type III secretion system ATPase	439	Virulence Associated Factor	Phase 2: March 2008	2DPY	42.8%	Yersinia pestis	Energy metabolism	ATP-proton motive force interconversion

IDP05728 (show subtarget assignments)	1	cloned	No	CD0251	126697822	fliI	flagellum-specific ATP synthase [Clostri...	439	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2DPY	45.6%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90923 (show subtarget assignments)	8	purified	No	STM0963	16764324	serS	seryl-tRNA synthetase [Salmonella typhim...	430	Predicted Essential	Community Requests	2DQ3	55.5%	Salmonella enterica

IDP05251 (show subtarget assignments)	1	cloned	No	lmo2747	16804784	serS	seryl-tRNA synthetase [Listeria monocyto...	427	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2DQ3	56.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90689 (show subtarget assignments)	8	soluble	No	Cj0389	15791756	serS	seryl-tRNA synthetase [Campylobacter jej...	411	Predicted Essential	Community Requests	2DQ3	48.4%	Campylobacter jejuni

IDP90835 (show subtarget assignments)	8	soluble	No	S0893	30062380	serS	seryl-tRNA synthetase [Shigella flexneri...	430	Predicted Essential	Community Requests	2DQ3	55.5%	Shigella flexneri

IDP05331 (show subtarget assignments)	1	soluble	No	SACOL0009	57651117	serS	seryl-tRNA synthetase [Staphylococcus au...	428	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2DQ3	51.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90714 (show subtarget assignments)	8	in_crystallization_trials	No	YPO1379	16121659	serS	seryl-tRNA synthetase [Yersinia pestis C...	430	Predicted Essential	Community Requests	2DQ3	55.3%	Yersinia pestis

IDP04574 (show subtarget assignments)	1	soluble	No	BAS0015	49183051		seryl-tRNA synthetase [Bacillus anthraci...	424	Proposed to be essential proteins	Phase 4: April 2009	2DQ3	57.8%	Bacillus anthracis

IDP90871 (show subtarget assignments)	8	in_crystallization_trials	No	VC1110	15641123		seryl-tRNA synthetase [Vibrio cholerae O...	435	Predicted Essential	Community Requests	2DQ3	50.3%	Vibrio cholerae

IDP04359 (show subtarget assignments)	1	cloned	No	YPO1414	218928562	pepN	aminopeptidase N [Yersinia pestis CO92]	871	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	77.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04077 (show subtarget assignments)	1	crystallized	No	FTT1793c	56708781	pepN	aminopeptidase N [Francisella tularensis...	864	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DQ6	48.9%	Francisella tularensis

IDP02107 (show subtarget assignments)	1	cloned	No	GBAA2607	47778067		lipase, putative [Bacillus anthracis str...	400	Conserved; Involved in sporulation; Vaccine Target; Drug target functions	Phase 3: June 2008	2DSN	48%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP00083 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0073	16418570	caiA	putative acyl-CoA dehydrogenase, carniti...	380	Essential	Phase 1: October 2007	2DVL	32.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00007 (show subtarget assignments)	0	work_stopped	No	BA_0847	30254435	racE-1	glutamate racemase	276	Drug Target Homolog	Phase 1: October 2007	2DWU	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04406 (show subtarget assignments)	1	in_crystallization_trials	No	VC1053	15641066		adenine phosphoribosyltransferase [Vibri...	181	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2DY0	73.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01230 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4638	33300883		Adenine phosphoribosyltransferase (APRT)...	170	Drug Target Function	Phase 2: March 2008	2DY0	52.4%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP91729 (show subtarget assignments)	8	selected	No	NP_660186	21735544	MAP2K7	dual specificity mitogen-activated prote...	419	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2DYL	72.3%	Homo sapiens

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP00019 (show subtarget assignments)	1	cloned	No	BA_4843	30259344	pykA-2	pyruvate kinase	585	Drug Target Homolog	Phase 1: October 2007	2E28	69.6%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP91823 (show subtarget assignments)	8	soluble	No	b1854	1788160	pykA	pyruvate kinase II [Escherichia coli str...	480	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	2E28	40.6%	Escherichia coli

IDP01685 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0757	56707872	galU	UTP--glucose-1-phosphate uridylyltransfe...	287	Conserved; Drug target functions	Phase 3: June 2008	2E3D	47.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02736 (show subtarget assignments)	1	cloned	No	GBAA4352	47778283	argD	acetylornithine aminotransferase [Bacill...	386	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	44%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02697 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3029	47528319		succinylornithine transaminase, putative...	405	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	37.5%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02577 (show subtarget assignments)	1	purified	No	GBAA5546	47530866	atpC	F0F1 ATP synthase subunit epsilon [Bacil...	133	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E5Y	69.9%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02014 (show subtarget assignments)	1	soluble	No	STM2341	16765668		putative transketolase [Salmonella typhi...	276	Conserved; Drug target functions	Phase 3: June 2008	2E6K	33%	Salmonella enterica	Energy metabolism	Pentose phosphate pathway

IDP04429 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4879	47530172	argH-2	argininosuccinate lyase [Bacillus anthra...	462	conserved gene; putative drug target function;	Phase 4: April 2009	2E9F	48.3%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02396 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3604	47528890	argH-1	argininosuccinate lyase [Bacillus anthra...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E9F	27.5%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP90641 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0099	15791487	birA	biotin--protein ligase [Campylobacter je...	217	Predicted Essential	Community Requests	2EAY	27.2%	Campylobacter jejuni

IDP91246 (show subtarget assignments)	8	expressed	No	HP0202	2313291		beta-ketoacyl-acyl carrier protein synth...	331	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2EBD	43.8%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP01493 (show subtarget assignments)	1	diffraction	No	VCA0751	161582040		3-oxoacyl-(acyl carrier protein) synthas...	362	Drug Target Function	Phase 2: March 2008	2EBD	40.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01213 (show subtarget assignments)	1	expressed	No	BA_3251	30257808		3-oxoacyl-(acyl-carrier-protein) synthas...	329	Drug Target Function	Phase 2: March 2008	2EBD	34.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91234 (show subtarget assignments)	8	cloned	No	NT04EC1734	26107956		Hypothetical protein c1689 [Escherichia ...	335	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2EBD	29.3%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90108 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_013	68449087		bifunctional zinc finger-like protein/E3...	242	similar to VARV BEN68-zinc finger-like protein	Community Requests	2ECW	8.3%	Monkeypox virus

IDP90176 (show subtarget assignments)	8	expressed	No	AAM13470.1	20153009	CPXV023 CDS	CPXV023 protein	242	zinc-finger-like protein	Community Requests	2ECW	8.3%	Cowpox virus	host defense modulator	0

IDP02834 (show subtarget assignments)	1	expressed	No	GBAA4975	47530273	moaC	molybdenum cofactor biosynthesis protein...	161	Conserved; Drug target functions	Phase 3: June 2008	2EEY	69.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP05257 (show subtarget assignments)	1	crystallized	No	CD2748	126700363		putative transferase [Clostridium diffic...	165	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2EG0	48.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP91171 (show subtarget assignments)	8	expressed	No	CT_370	9087121		RecName: Full=Shikimate biosynthesis pro...	478	potential drug target / Shikimate pathway enzyme	Community Requests	2EGG	18.2%	Chlamydia trachomatis

IDP02833 (show subtarget assignments)	1	cloned	No	GBAA4561	47529857	aroE	shikimate 5-dehydrogenase [Bacillus anth...	308	Conserved; Drug target functions	Phase 3: June 2008	2EGG	49.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP04092 (show subtarget assignments)	1	cloned	No	CPF_1925	110801017	spoVS	stage V sporulation protein S [Clostridi...	86	conserved gene; putative drug target function;	Phase 4: April 2009	2EH1	57%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02452 (show subtarget assignments)	1	purified	No	GBAA3312	47528597		diaminobutyrate--2-oxoglutarate aminotra...	424	Conserved; Essential; Drug target functions	Phase 3: June 2008	2EH6	31.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP04642 (show subtarget assignments)	1	expressed	No	FTT0716	56707835	upp	uracil phosphoribosyltransferase [Franci...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2EHJ	69.2%	Francisella tularensis

IDP01761 (show subtarget assignments)	1	cloned	No	GBAA5606	47530928		aminopeptidase, putative [Bacillus anthr...	466	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2EK8	33%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01894 (show subtarget assignments)	1	in_crystallization_trials	No	STM0564	16763941		pyridine nucleotide-disulfide oxidoreduc...	441	Conserved; Drug target functions	Phase 3: June 2008	2EQ6	32.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01864 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5568	47778411		sua5/yciO/yrdC/ywlC family protein [Baci...	346	Essential; Involved in sporulation;	Phase 3: June 2008	2EQA	43.4%	Bacillus anthracis	Unknown function	General

IDP91020 (show subtarget assignments)	8	in_crystallization_trials	No	y2842	22126718		hypothetical protein y2842 [Yersinia pes...	378	other biological interest / putative periplasmic iron-binding protein	Community Requests	2ETV	22.8%	Yersinia pestis

IDP02390 (show subtarget assignments)	1	cloned	No	CBU_1718	29542276	groEL	chaperonin, 60 kDa [Coxiella burnetii RS...	552	Conserved; Drug target functions	Phase 3: June 2008	2EU1	75.5%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP00996 (show subtarget assignments)	1	in_crystallization_trials	No	STM2310	16765637	menF	menaquinone-specific isochorismate synth...	431	Drug Target Function	Phase 2: March 2008	2EUA	78.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02150 (show subtarget assignments)	1	cloned	No	lmo1104	16803144		hypothetical protein lmo1104 [Listeria m...	336	Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...	Phase 3: June 2008	2EVR	15.5%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP04260 (show subtarget assignments)	1	cloned	No	CPF_2020	110798885	pilT	twitching motility protein PilT [Clostri...	350	conserved gene; putative drug target function;	Phase 4: April 2009	2EWV	49.1%	Clostridium perfringens	Cellular processes	Chemotaxis and motility

IDP00535 (show subtarget assignments)	1	purified	No	YPO3506	16123652	dacB	D-alanyl-D-alanine carboxypeptidase/endo...	482	Drug Target Function	Phase 2: March 2008	2EX2	77.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90937 (show subtarget assignments)	8	cloned	No	YPO0110	16120456	priA	primosome assembly protein PriA	732	Predicted Essential	Community Requests	2EYQ	9.4%	Yersinia pestis

IDP01935 (show subtarget assignments)	1	expressed	No	CBU_0136	29540756	murC	UDP-N-acetylmuramate--alanine ligase [Co...	465	Conserved; Drug target functions	Phase 3: June 2008	2F00	47.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90657 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0556	16120884	murC	UDP-N-acetylmuramate--L-alanine ligase [...	491	Predicted Essential	Community Requests	2F00	86.2%	Yersinia pestis

IDP00906 (show subtarget assignments)	0	work_stopped	No	STM0129	16763519	murC	UDP-N-acetylmuramate--L-alanine ligase	491	Essential Gene	Phase 2: March 2008	2F00	94.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01452 (show subtarget assignments)	1	soluble	No	VC2400	15642397	murC	UDP-N-acetylmuramate--L-alanine ligase	506	Conserved Gene / Pathway	Phase 2: March 2008	2F00	69.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02309 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0239	56707396	murC	UDP-N-acetylmuramate--alanine ligase [Fr...	451	Conserved; Drug target functions	Phase 3: June 2008	2F00	36.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04318 (show subtarget assignments)	1	soluble	No	YPO0540	115346348	ilvH	acetolactate synthase isozyme III small ...	164	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2F1F	87.2%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP90778 (show subtarget assignments)	8	soluble	No	Cj0575	15791935	ilvH	acetolactate synthase 3 regulatory subun...	154	Predicted Essential	Community Requests	2F1F	40.3%	Campylobacter jejuni

IDP04488 (show subtarget assignments)	1	expressed	No	YPO3685	115349305	yhcQ	putative HlyD family secretion protein [...	311	conserved gene; putative drug target function;	Phase 4: April 2009	2F1M	17%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP92079 (show subtarget assignments)	8	selected	No	TGME49_101120	237844673		acetyil CoA acetyltransferase/thiolase, ...	413	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F2S	45.9%	Toxoplasma gondii

IDP92036 (show subtarget assignments)	8	selected	No	TGME49_033720	237837845		RNA polymerase, putative [Toxoplasma gon...	149	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F3I	36.9%	Toxoplasma gondii

IDP04706 (show subtarget assignments)	1	expressed	No	BAS0105	49183139		30S ribosomal protein S12 [Bacillus anth...	140	Proposed to be essential proteins	Phase 4: April 2009	2F4V	71.4%	Bacillus anthracis

IDP05169 (show subtarget assignments)	1	soluble	No	BA_1952	30256610		NLP/P60 family protein [Bacillus anthrac...	420	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2F68	14%	Bacillus anthracis	Unknown function: General

IDP02442 (show subtarget assignments)	1	soluble	No	GBAA4092	47778244		prophage LambdaBa02, Clp protease family...	251	Drug target motif; Drug target functions	Phase 3: June 2008	2F6I	21.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01675
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5217

47530523

ABC transporter ATP-binding protein [Bac...

261

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2D2E

57.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00127
(show subtarget assignments)

1

soluble

No

NT01ST1705

16764721

sufC

cysteine desulfurase ATPase component

248

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2D3W

92.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP02099
(show subtarget assignments)

1

cloned

No

FTT0972

56708065

ABC transporter, ATP-binding protein [Fr...

249

Conserved; Drug target functions

Phase 3: June 2008

2D3W

57.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02511
(show subtarget assignments)

1

soluble

No

CBU_1359

29541924

sufC

ABC transporter, ATP-binding protein [Co...

244

Conserved; Drug target functions

Phase 3: June 2008

2D3W

63.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00099
(show subtarget assignments)

0

work_stopped

No

NT02SF1983

30041448

ynhD

putative ATP-binding component of a tran...

248

Conserved; CD; Drug target functions

Phase 1: October 2007

2D3W

99.6%

Shigella flexneri

Transport and binding proteins

Unknown substrate

IDP00949
(show subtarget assignments)

1

purified

No

STM1102

16764460

hpaE

4-hydroxyphenylacetate catabolism

488

Conserved Gene / Pathway

Phase 2: March 2008

2D4E

47.7%

Salmonella enterica

Central intermediary metabolism

Other

IDP00953
(show subtarget assignments)

1

in_crystallization_trials

No

STM1183

16764539

flgK

flagellar hook-associated protein FlgK

553

Conserved Gene / Pathway

Phase 2: March 2008

2D4Y

83.5%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP01773
(show subtarget assignments)

1

soluble

No

Cj1466

15792783

flgK

flagellar hook-associated protein FlgK [...

608

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

2D4Y

18.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00070
(show subtarget assignments)

0

work_stopped

No

NT01ST1465

16419700

flgK

hook-filament junction protein 1

553

Virulence

Phase 1: October 2007

2D4Y

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP02079
(show subtarget assignments)

1

expressed

No

Cj0173c

15791560

iron ABC transporter, ATP binding subuni...

302

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2D62

35.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00760
(show subtarget assignments)

1

soluble

No

SACOL0192

57285394

maltose ABC transporter, ATP-binding pro...

365

Drug Target Function

Phase 2: March 2008

2D62

53.5%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01423
(show subtarget assignments)

1

purified

No

VC1552

15641560

ugpC

glycerol-3-phosphate ABC transporter, AT...

393

Conserved Gene / Pathway

Phase 2: March 2008

2D62

45.5%

Vibrio cholerae

Transport and binding proteins

Other

IDP00713
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1108

57285894

spermidine/putrescine ABC transporter, A...

364

Conserved Gene / Pathway

Phase 2: March 2008

2D62

40.4%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01336
(show subtarget assignments)

1

purified

No

VC1428

15641439

potA

putrescine/spermidine ABC transporter AT...

377

Conserved Gene / Pathway

Phase 2: March 2008

2D62

41.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00149
(show subtarget assignments)

1

expressed

No

VCA0230

15600999

vctC

vibriobactin and enterobactin ABC transp...

254

Virulence

Phase 1: October 2007

2D62

28%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02503
(show subtarget assignments)

1

cloned

No

YPO2502

16122723

gutB

putative zinc-binding dehydrogenase [Yer...

408

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

2D8A

30.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Chlorophyll and bacteriochlorphyll

IDP02277
(show subtarget assignments)

1

crystallized

No

GBAA1434

47526709

glycerate dehydrogenase [Bacillus anthra...

323

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2DBQ

48.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP00128
(show subtarget assignments)

1

soluble

No

NT01ST3027

16765755

pdxK

mp65f07.r1 Soares_thymus_2NbMT Mus muscu...

288

Essential

Phase 1: October 2007

2DDM

65.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP90692
(show subtarget assignments)

8

purified

No

YPO1638

16121906

trmU

tRNA (5-methylaminomethyl-2-thiouridylat...

371

Predicted Essential

Community Requests

2DER

85.7%

Yersinia pestis

IDP02706
(show subtarget assignments)

1

cloned

No

FTT0470

56707612

apaH

diadenosine tetraphosphatase [Francisell...

275

Drug Target

Phase 3: June 2008

2DFJ

37.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP00524
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0490

16120820

apaH

diadenosine tetraphosphatase

289

Conserved Gene / Pathway

Phase 2: March 2008

2DFJ

73.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP01322
(show subtarget assignments)

1

purified

No

VC2296

15642294

bolA protein

106

Conserved Gene / Pathway

Phase 2: March 2008

2DHM

50.9%

Vibrio cholerae

Cellular processes

Other

IDP02605
(show subtarget assignments)

1

cloned

No

YPO3502

16123648

hflB

ATP-dependent metalloprotease [Yersinia ...

644

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

2DHR

40.7%

Yersinia pestis

Cellular processes

Cell division

IDP02738
(show subtarget assignments)

1

cloned

No

FTT1310c

56708367

hflB

ATP-dependent metalloprotease [Francisel...

638

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2DHR

39.3%

Francisella tularensis

N/A

IDP91903
(show subtarget assignments)

8

selected

No

SpneCM_010100005798

298255108

hypothetical protein SpneCM_05798 [Strep...

663

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2DHR

40.7%

Streptococcus pneumoniae

IDP90975
(show subtarget assignments)

8

cloned

No

y0011

22123933

hypothetical protein y0011 [Yersinia pes...

229

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

2DI3

21.4%

Yersinia pestis

IDP92027
(show subtarget assignments)

8

selected

No

TGME49_017580

237844055

DNA-directed RNA polymerases III, 39 kDa...

325

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2DK5

9.2%

Toxoplasma gondii

IDP02708
(show subtarget assignments)

1

cloned

No

lmo0291

16802337

hypothetical protein lmo0291 [Listeria m...

276

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2DKF

13.4%

Listeria monocytogenes

Cellular processes

Toxin production and resistance

IDP91733
(show subtarget assignments)

8

selected

No

P88946_HHV8

0

449

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2DLL

6.9%

Human herpesvirus

IDP92080
(show subtarget assignments)

8

selected

No

TGME49_105290

237842049

vacuolar ATP synthase subunit E, putativ...

236

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2DM9

25%

Toxoplasma gondii

IDP02188
(show subtarget assignments)

1

expressed

No

YPO0267

16120605

type III secretion system ATPase [Yersin...

445

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

2DPY

43.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP91477
(show subtarget assignments)

8

expressed

No

VPA1338

28901193

putative ATPase YscN [Vibrio parahaemoly...

420

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2DPY

34.5%

Vibrio parahaemolyticus

IDP02097
(show subtarget assignments)

1

cloned

No

Cj0195

15791582

fliI

flagellum-specific ATP synthase [Campylo...

461

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

2DPY

40.3%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP91506
(show subtarget assignments)

8

expressed

No

VP1668

28898442

type III secretion system ATPase [Vibrio...

440

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2DPY

44.1%

Vibrio parahaemolyticus

IDP00450
(show subtarget assignments)

1

cloned

No

YPCD1.40

16082728

yscN

type III secretion system ATPase

439

Virulence Associated Factor

Phase 2: March 2008

2DPY

42.8%

Yersinia pestis

Energy metabolism

ATP-proton motive force interconversion

IDP05728
(show subtarget assignments)

1

cloned

No

CD0251

126697822

fliI

flagellum-specific ATP synthase [Clostri...

439

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2DPY

45.6%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90923
(show subtarget assignments)

8

purified

No

STM0963

16764324

serS

seryl-tRNA synthetase [Salmonella typhim...

430

Predicted Essential

Community Requests

2DQ3

55.5%

Salmonella enterica

IDP05251
(show subtarget assignments)

1

cloned

No

lmo2747

16804784

serS

seryl-tRNA synthetase [Listeria monocyto...

427

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2DQ3

56.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90689
(show subtarget assignments)

8

soluble

No

Cj0389

15791756

serS

seryl-tRNA synthetase [Campylobacter jej...

411

Predicted Essential

Community Requests

2DQ3

48.4%

Campylobacter jejuni

IDP90835
(show subtarget assignments)

8

soluble

No

S0893

30062380

serS

seryl-tRNA synthetase [Shigella flexneri...

430

Predicted Essential

Community Requests

2DQ3

55.5%

Shigella flexneri

IDP05331
(show subtarget assignments)

1

soluble

No

SACOL0009

57651117

serS

seryl-tRNA synthetase [Staphylococcus au...

428

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2DQ3

51.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90714
(show subtarget assignments)

8

in_crystallization_trials

No

YPO1379

16121659

serS

seryl-tRNA synthetase [Yersinia pestis C...

430

Predicted Essential

Community Requests

2DQ3

55.3%

Yersinia pestis

IDP04574
(show subtarget assignments)

1

soluble

No

BAS0015

49183051

seryl-tRNA synthetase [Bacillus anthraci...

424

Proposed to be essential proteins

Phase 4: April 2009

2DQ3

57.8%

Bacillus anthracis

IDP90871
(show subtarget assignments)

8

in_crystallization_trials

No

VC1110

15641123

seryl-tRNA synthetase [Vibrio cholerae O...

435

Predicted Essential

Community Requests

2DQ3

50.3%

Vibrio cholerae

IDP04359
(show subtarget assignments)

1

cloned

No

YPO1414

218928562

pepN

aminopeptidase N [Yersinia pestis CO92]

871

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

77.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04077
(show subtarget assignments)

1

crystallized

No

FTT1793c

56708781

pepN

aminopeptidase N [Francisella tularensis...

864

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DQ6

48.9%

Francisella tularensis

IDP02107
(show subtarget assignments)

1

cloned

No

GBAA2607

47778067

lipase, putative [Bacillus anthracis str...

400

Conserved; Involved in sporulation; Vaccine Target; Drug target functions

Phase 3: June 2008

2DSN

48%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP00083
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0073

16418570

caiA

putative acyl-CoA dehydrogenase, carniti...

380

Essential

Phase 1: October 2007

2DVL

32.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00007
(show subtarget assignments)

0

work_stopped

No

BA_0847

30254435

racE-1

glutamate racemase

276

Drug Target Homolog

Phase 1: October 2007

2DWU

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04406
(show subtarget assignments)

1

in_crystallization_trials

No

VC1053

15641066

adenine phosphoribosyltransferase [Vibri...

181

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2DY0

73.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01230
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4638

33300883

Adenine phosphoribosyltransferase (APRT)...

170

Drug Target Function

Phase 2: March 2008

2DY0

52.4%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP91729
(show subtarget assignments)

8

selected

No

NP_660186

21735544

MAP2K7

dual specificity mitogen-activated prote...

419

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2DYL

72.3%

Homo sapiens

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP00019
(show subtarget assignments)

1

cloned

No

BA_4843

30259344

pykA-2

pyruvate kinase

585

Drug Target Homolog

Phase 1: October 2007

2E28

69.6%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP91823
(show subtarget assignments)

8

soluble

No

b1854

1788160

pykA

pyruvate kinase II [Escherichia coli str...

480

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

2E28

40.6%

Escherichia coli

IDP01685
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0757

56707872

galU

UTP--glucose-1-phosphate uridylyltransfe...

287

Conserved; Drug target functions

Phase 3: June 2008

2E3D

47.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02736
(show subtarget assignments)

1

cloned

No

GBAA4352

47778283

argD

acetylornithine aminotransferase [Bacill...

386

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

44%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02697
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3029

47528319

succinylornithine transaminase, putative...

405

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

37.5%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02577
(show subtarget assignments)

1

purified

No

GBAA5546

47530866

atpC

F0F1 ATP synthase subunit epsilon [Bacil...

133

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E5Y

69.9%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02014
(show subtarget assignments)

1

soluble

No

STM2341

16765668

putative transketolase [Salmonella typhi...

276

Conserved; Drug target functions

Phase 3: June 2008

2E6K

33%

Salmonella enterica

Energy metabolism

Pentose phosphate pathway

IDP04429
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4879

47530172

argH-2

argininosuccinate lyase [Bacillus anthra...

462

conserved gene; putative drug target function;

Phase 4: April 2009

2E9F

48.3%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02396
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3604

47528890

argH-1

argininosuccinate lyase [Bacillus anthra...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E9F

27.5%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP90641
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0099

15791487

birA

biotin--protein ligase [Campylobacter je...

217

Predicted Essential

Community Requests

2EAY

27.2%

Campylobacter jejuni

IDP91246
(show subtarget assignments)

8

expressed

No

HP0202

2313291

beta-ketoacyl-acyl carrier protein synth...

331

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2EBD

43.8%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP01493
(show subtarget assignments)

1

diffraction

No

VCA0751

161582040

3-oxoacyl-(acyl carrier protein) synthas...

362

Drug Target Function

Phase 2: March 2008

2EBD

40.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01213
(show subtarget assignments)

1

expressed

No

BA_3251

30257808

3-oxoacyl-(acyl-carrier-protein) synthas...

329

Drug Target Function

Phase 2: March 2008

2EBD

34.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91234
(show subtarget assignments)

8

cloned

No

NT04EC1734

26107956

Hypothetical protein c1689 [Escherichia ...

335

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2EBD

29.3%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90108
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_013

68449087

bifunctional zinc finger-like protein/E3...

242

similar to VARV BEN68-zinc finger-like protein

Community Requests

2ECW

8.3%

Monkeypox virus

IDP90176
(show subtarget assignments)

8

expressed

No

AAM13470.1

20153009

CPXV023 CDS

CPXV023 protein

242

zinc-finger-like protein

Community Requests

2ECW

8.3%

Cowpox virus

host defense modulator

0

IDP02834
(show subtarget assignments)

1

expressed

No

GBAA4975

47530273

moaC

molybdenum cofactor biosynthesis protein...

161

Conserved; Drug target functions

Phase 3: June 2008

2EEY

69.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP05257
(show subtarget assignments)

1

crystallized

No

CD2748

126700363

putative transferase [Clostridium diffic...

165

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2EG0

48.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP91171
(show subtarget assignments)

8

expressed

No

CT_370

9087121

RecName: Full=Shikimate biosynthesis pro...

478

potential drug target / Shikimate pathway enzyme

Community Requests

2EGG

18.2%

Chlamydia trachomatis

IDP02833
(show subtarget assignments)

1

cloned

No

GBAA4561

47529857

aroE

shikimate 5-dehydrogenase [Bacillus anth...

308

Conserved; Drug target functions

Phase 3: June 2008

2EGG

49.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP04092
(show subtarget assignments)

1

cloned

No

CPF_1925

110801017

spoVS

stage V sporulation protein S [Clostridi...

86

conserved gene; putative drug target function;

Phase 4: April 2009

2EH1

57%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02452
(show subtarget assignments)

1

purified

No

GBAA3312

47528597

diaminobutyrate--2-oxoglutarate aminotra...

424

Conserved; Essential; Drug target functions

Phase 3: June 2008

2EH6

31.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP04642
(show subtarget assignments)

1

expressed

No

FTT0716

56707835

upp

uracil phosphoribosyltransferase [Franci...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2EHJ

69.2%

Francisella tularensis

IDP01761
(show subtarget assignments)

1

cloned

No

GBAA5606

47530928

aminopeptidase, putative [Bacillus anthr...

466

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2EK8

33%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01894
(show subtarget assignments)

1

in_crystallization_trials

No

STM0564

16763941

pyridine nucleotide-disulfide oxidoreduc...

441

Conserved; Drug target functions

Phase 3: June 2008

2EQ6

32.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01864
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5568

47778411

sua5/yciO/yrdC/ywlC family protein [Baci...

346

Essential; Involved in sporulation;

Phase 3: June 2008

2EQA

43.4%

Bacillus anthracis

Unknown function

General

IDP91020
(show subtarget assignments)

8

in_crystallization_trials

No

y2842

22126718

hypothetical protein y2842 [Yersinia pes...

378

other biological interest / putative periplasmic iron-binding protein

Community Requests

2ETV

22.8%

Yersinia pestis

IDP02390
(show subtarget assignments)

1

cloned

No

CBU_1718

29542276

groEL

chaperonin, 60 kDa [Coxiella burnetii RS...

552

Conserved; Drug target functions

Phase 3: June 2008

2EU1

75.5%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP00996
(show subtarget assignments)

1

in_crystallization_trials

No

STM2310

16765637

menF

menaquinone-specific isochorismate synth...

431

Drug Target Function

Phase 2: March 2008

2EUA

78.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02150
(show subtarget assignments)

1

cloned

No

lmo1104

16803144

hypothetical protein lmo1104 [Listeria m...

336

Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...

Phase 3: June 2008

2EVR

15.5%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP04260
(show subtarget assignments)

1

cloned

No

CPF_2020

110798885

pilT

twitching motility protein PilT [Clostri...

350

conserved gene; putative drug target function;

Phase 4: April 2009

2EWV

49.1%

Clostridium perfringens

Cellular processes

Chemotaxis and motility

IDP00535
(show subtarget assignments)

1

purified

No

YPO3506

16123652

dacB

D-alanyl-D-alanine carboxypeptidase/endo...

482

Drug Target Function

Phase 2: March 2008

2EX2

77.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90937
(show subtarget assignments)

8

cloned

No

YPO0110

16120456

priA

primosome assembly protein PriA

732

Predicted Essential

Community Requests

2EYQ

9.4%

Yersinia pestis

IDP01935
(show subtarget assignments)

1

expressed

No

CBU_0136

29540756

murC

UDP-N-acetylmuramate--alanine ligase [Co...

465

Conserved; Drug target functions

Phase 3: June 2008

2F00

47.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90657
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0556

16120884

murC

UDP-N-acetylmuramate--L-alanine ligase [...

491

Predicted Essential

Community Requests

2F00

86.2%

Yersinia pestis

IDP00906
(show subtarget assignments)

0

work_stopped

No

STM0129

16763519

murC

UDP-N-acetylmuramate--L-alanine ligase

491

Essential Gene

Phase 2: March 2008

2F00

94.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01452
(show subtarget assignments)

1

soluble

No

VC2400

15642397

murC

UDP-N-acetylmuramate--L-alanine ligase

506

Conserved Gene / Pathway

Phase 2: March 2008

2F00

69.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02309
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0239

56707396

murC

UDP-N-acetylmuramate--alanine ligase [Fr...

451

Conserved; Drug target functions

Phase 3: June 2008

2F00

36.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04318
(show subtarget assignments)

1

soluble

No

YPO0540

115346348

ilvH

acetolactate synthase isozyme III small ...

164

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2F1F

87.2%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP90778
(show subtarget assignments)

8

soluble

No

Cj0575

15791935

ilvH

acetolactate synthase 3 regulatory subun...

154

Predicted Essential

Community Requests

2F1F

40.3%

Campylobacter jejuni

IDP04488
(show subtarget assignments)

1

expressed

No

YPO3685

115349305

yhcQ

putative HlyD family secretion protein [...

311

conserved gene; putative drug target function;

Phase 4: April 2009

2F1M

17%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP92079
(show subtarget assignments)

8

selected

No

TGME49_101120

237844673

acetyil CoA acetyltransferase/thiolase, ...

413

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F2S

45.9%

Toxoplasma gondii

IDP92036
(show subtarget assignments)

8

selected

No

TGME49_033720

237837845

RNA polymerase, putative [Toxoplasma gon...

149

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F3I

36.9%

Toxoplasma gondii

IDP04706
(show subtarget assignments)

1

expressed

No

BAS0105

49183139

30S ribosomal protein S12 [Bacillus anth...

140

Proposed to be essential proteins

Phase 4: April 2009

2F4V

71.4%

Bacillus anthracis

IDP05169
(show subtarget assignments)

1

soluble

No

BA_1952

30256610

NLP/P60 family protein [Bacillus anthrac...

420

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2F68

14%

Bacillus anthracis

Unknown function: General

IDP02442
(show subtarget assignments)

1

soluble

No

GBAA4092

47778244

prophage LambdaBa02, Clp protease family...

251

Drug target motif; Drug target functions

Phase 3: June 2008

2F6I

21.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides