Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02600 (show subtarget assignments)	1	expressed	No	STM2279	16765606	yfaE	2Fe-2S ferredoxin YfaE [Salmonella typhi...	84	Conserved; Drug target functions	Phase 3: June 2008	1IUE	37.2%	Salmonella enterica	Unknown function	General

IDP05409 (show subtarget assignments)	1	soluble	No	BA_2728	30257334		putative pullulanase [Bacillus anthracis...	852	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2WAN	37.2%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02213 (show subtarget assignments)	1	expressed	No	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP05217 (show subtarget assignments)	1	in_crystallization_trials	No	CD3421	126701044	hemC	porphobilinogen deaminase [Clostridium d...	301	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PDA	37.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01979 (show subtarget assignments)	1	purified	No	STM3458	16766747	yheR	glutathione-regulated potassium-efflux s...	183	Conserved; Drug target functions	Phase 3: June 2008	3EYW	37.2%	Salmonella enterica	Energy metabolism	Electron transport

IDP90589 (show subtarget assignments)	8	soluble	No	VC0296	15640324		acetyl-CoA carboxylase [Vibrio cholerae ...	196	Predicted Essential	Community Requests	1A6X	37.2%	Vibrio cholerae

IDP05626 (show subtarget assignments)	1	soluble	No	CD1430	126699034		putative exported polysaccharide deacety...	274	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1NY1	37.2%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP00004 (show subtarget assignments)	1	soluble	No	BA_0001	38257418		Chromosomal replication initiator protei...	446	Drug Target Homolog	Phase 1: October 2007	2Z4R	37.2%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP04685 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3438	47528724		alcohol dehydrogenase, zinc-containing [...	335	virulence factor; putative drug target function;	Phase 4: April 2009	3GAZ	37.3%	Bacillus anthracis	Energy metabolism	Fermentation

IDP01070 (show subtarget assignments)	1	expressed	No	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP00908 (show subtarget assignments)	1	expressed	No	STM0143	16763533	hofB	hypothetical protein STM0143	461	Conserved Gene / Pathway	Phase 2: March 2008	1P9R	37.3%	Salmonella enterica	Cell envelope	Surface structures

IDP04361 (show subtarget assignments)	1	soluble	No	YPO2803	218929869	bglB	putative beta-glucosidase [Yersinia pest...	793	drug target; putative drug target function;	Phase 4: April 2009	2X40	37.3%	Yersinia pestis	Energy metabolism	Sugars

IDP00544 (show subtarget assignments)	1	purified	No	YPO2746	16122950	fadI	3-ketoacyl-CoA thiolase	436	Virulence Associated Factor	Phase 2: March 2008	1ULQ	37.4%	Yersinia pestis	Cellular processes	Detoxification

IDP01934 (show subtarget assignments)	1	soluble	No	GBAA0385	47525656		chitinase B [Bacillus anthracis str. 'Am...	674	Drug target motif; Drug target functions	Phase 3: June 2008	1ITX	37.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02506 (show subtarget assignments)	1	soluble	No	FTT0609	56707734		peptidase, M24 family protein [Francisel...	597	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3CTZ	37.4%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00779 (show subtarget assignments)	1	purified	No	SACOL0691	57285661	sirR	iron-dependent repressor	214	Conserved Gene / Pathway	Phase 2: March 2008	3HRS	37.4%	Staphylococcus aureus	Regulatory functions	DNA interactions

IDP91972 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100003825	298254730		iron-compound ABC transporter, iron-comp...	321	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2CHU	37.4%	Streptococcus pneumoniae

IDP04168 (show subtarget assignments)	1	purified	No	VC2142	15642141		flagellin [Vibrio cholerae O1 biovar elt...	376	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3K8V	37.5%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP02753 (show subtarget assignments)	1	expressed	No	GBAA4662	47529960	nadB	L-aspartate oxidase [Bacillus anthracis ...	509	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CHU	37.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02697 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3029	47528319		succinylornithine transaminase, putative...	405	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	37.5%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP00752 (show subtarget assignments)	1	purified	No	SACOL2211	57284992		ABC transporter, ATP-binding protein	269	Drug Target Function	Phase 2: March 2008	3GFO	37.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00976 (show subtarget assignments)	1	in_crystallization_trials	No	STM1879	16765221	ptrB	protease 2	683	Drug Target Function	Phase 2: March 2008	2XE4	37.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02492 (show subtarget assignments)	1	crystallized	No	FTT1559c	56708586	proC	pyrroline-5-carboxylate reductase [Franc...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	37.6%	Francisella tularensis	Amino acid biosynthesis	Glutamate family

IDP02427 (show subtarget assignments)	1	purified	No	GBAA3553	47528837	pepF-2	oligoendopeptidase F [Bacillus anthracis...	595	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QR4	37.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01506 (show subtarget assignments)	1	in_crystallization_trials	No	VCA1113	15601861		spermidine/putrescine ABC transporter, p...	343	Conserved Gene / Pathway	Phase 2: March 2008	1POT	37.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90724 (show subtarget assignments)	8	expressed	No	Cj1719c	15793022	leuA	2-isopropylmalate synthase [Campylobacte...	511	Predicted Essential	Community Requests	3RMJ	37.6%	Campylobacter jejuni

IDP01303 (show subtarget assignments)	1	purified	No	VC0573	15640595		ubiquinol--cytochrome c reductase, iron-...	197	Conserved Gene / Pathway	Phase 2: March 2008	2FYN	37.6%	Vibrio cholerae	Energy metabolism	Electron transport

IDP02631 (show subtarget assignments)	1	expressed	No	GBAA1440	47526715	cysH	phosphoadenosine phosphosulfate reductas...	226	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GOY	37.6%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP90298 (show subtarget assignments)	8	selected	No	TGME49_120190	211967550		bradyzoite-specific surface protein, put...	398	TgSRS9 is one of the few in the SAG1 family that is expressed only in bradyzoite...	Community Requests	2JKS	37.7%	Toxoplasma gondii

IDP01825 (show subtarget assignments)	1	cloned	No	STM2265	16765593	ada	O6-methylguanine-DNA methyltransferase/t...	353	Conserved; Drug target functions	Phase 3: June 2008	1SFE	37.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01803 (show subtarget assignments)	1	soluble	No	CBU_0646	29541247	ribE	riboflavin synthase, alpha subunit [Coxi...	202	Conserved; Drug target functions	Phase 3: June 2008	1I8D	37.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00024 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0039	33516921		Dimethyladenosine transferase (S-adenosy...	292	Virulence	Phase 1: October 2007	3GRR	37.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01692 (show subtarget assignments)	1	cloned	No	FTT1671	56708681	ribD	riboflavin biosynthesis protein ribD [Fr...	355	Conserved; Drug target functions	Phase 3: June 2008	2B3Z	37.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00827 (show subtarget assignments)	1	expressed	No	SACOL2507	57285192	sarU	staphylococcal accessory regulator U	247	Conserved Gene / Pathway	Phase 2: March 2008	1P4X	37.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01644 (show subtarget assignments)	1	cloned	No	FTT0626	56707751	lon	DNA-binding, ATP-dependent protease La [...	774	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3M6A	37.7%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00637 (show subtarget assignments)	1	cloned	No	SACOL1727	57284738	infC	translation initiation factor IF-3	175	Drug Target Function	Phase 2: March 2008	1TIG	37.7%	Staphylococcus aureus	Protein synthesis	Translation factors

IDP05726 (show subtarget assignments)	1	soluble	No	BA_3927	30258439		lipoprotein, Bmp family [Bacillus anthra...	355	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	37.7%	Bacillus anthracis	Cell envelope: Other

IDP04373 (show subtarget assignments)	1	cloned	No	YPO3097	218930139	manB	phosphomannomutase [Yersinia pestis CO92...	457	drug target; virulence factor; putative drug target function;	Phase 4: April 2009	3UW2	37.8%	Yersinia pestis	Energy metabolism	Sugars

IDP05714 (show subtarget assignments)	1	purified	No	BA_0175	30253683		putative ABC transporter, substrate-bind...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3K2D	37.8%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP02706 (show subtarget assignments)	1	cloned	No	FTT0470	56707612	apaH	diadenosine tetraphosphatase [Francisell...	275	Drug Target	Phase 3: June 2008	2DFJ	37.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP01643 (show subtarget assignments)	1	crystallized	No	YPO2892	16123083	hscA	chaperone protein HscA [Yersinia pestis ...	650	CD; Drug target functions	Phase 3: June 2008	2KHO	37.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP00011 (show subtarget assignments)	1	soluble	No	BA_2222	30256868		alcohol dehydrogenase, iron-containing	392	Drug Target Homolog	Phase 1: October 2007	3OWO	37.8%	Bacillus anthracis	Energy metabolism	Fermentation

IDP01311 (show subtarget assignments)	1	soluble	No	VCA0726	15601482		molybdenum ABC transporter, periplasmic ...	254	Conserved Gene / Pathway	Phase 2: March 2008	1AMF	37.8%	Vibrio cholerae	Transport and binding proteins	Anions

IDP02629 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02787 (show subtarget assignments)	1	cloned	No	FTT0697	56707817	ftsI	penicillin binding protein (peptidoglyca...	564	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3OC2	37.9%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00039 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1960	30256617		aminoglycoside 6-adenylyltransferase, pu...	290	Virulence	Phase 1: October 2007	2PBE	37.9%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01354 (show subtarget assignments)	1	cloned	No	VC0003	15640035	trmE	tRNA modification GTPase TrmE	464	Conserved Gene / Pathway	Phase 2: March 2008	3GEH	37.9%	Vibrio cholerae	Cellular processes	Detoxification

IDP90650 (show subtarget assignments)	8	expressed	No	Cj0713	15792062	trmD	tRNA (guanine-N(1)-)-methyltransferase [...	234	Predicted Essential	Community Requests	3KY7	38%	Campylobacter jejuni

IDP91204 (show subtarget assignments)	8	cloned	No	BT_4215	29349623		shikimate 5-dehydrogenase [Bacteroides t...	248	potential drug target / Shikimate pathway enzyme	Community Requests	2HK7	38%	Bacteroides thetaiotaomicron

IDP91021 (show subtarget assignments)	8	cloned	No	y2872	22126749	yiuR	putative outer membrane receptor [Yersin...	665	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	2HDF	38%	Yersinia pestis

IDP00195 (show subtarget assignments)	1	cloned	No	YPO1009	16121311	-	probable peptidase	410	Similar to Essential SALTY	Phase 1: October 2007	1VIX	38%	Yersinia pestis	Hypothetical proteins	Conserved

IDP90697 (show subtarget assignments)	8	cloned	No	Cj0098	15791486	fmt	methionyl-tRNA formyltransferase [Campyl...	305	Predicted Essential	Community Requests	3R8X	38%	Campylobacter jejuni

IDP00758 (show subtarget assignments)	1	soluble	No	SACOL0140	57285343	cap5E	capsular polysaccharide biosynthesis pro...	342	Conserved Gene / Pathway	Phase 2: March 2008	2GN4	38%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02384 (show subtarget assignments)	1	expressed	No	GBAA3202	47528494	hscC	chaperone protein hscC [Bacillus anthrac...	566	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V7Y	38%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP00302 (show subtarget assignments)	1	expressed	No	CBU_1155	29654460	trpBF	N-(5'phosphoribosyl)anthranilate isomera...	600	Drug Target Function	Phase 2: March 2008	1V8Z	38%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01158 (show subtarget assignments)	1	expressed	No	BA_4669	30259165		ABC transporter, ATP-binding protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02596 (show subtarget assignments)	1	cloned	No	GBAA1269	47526536	odhB	dihydrolipoamide acetyltransferase [Baci...	418	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.1%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP00120 (show subtarget assignments)	1	expressed	No	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP91800 (show subtarget assignments)	8	in_crystallization_trials	No	p6418_01	219372022	sul2	dihydropteroate synthase [Escherichia co...	271	drug resistance / Deactivates antibiotic sulfonamide by ligating on p-aminobenzoic acid; we will c...	Community Requests	2Y5J	38.1%	Escherichia coli

IDP91192 (show subtarget assignments)	1	in_crystallization_trials	No	BAD95814	62857277	neoU	aminoglycoside 3'-phosphotransferase [St...	268	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R78	38.1%	Streptomyces fradiae

IDP02456 (show subtarget assignments)	1	crystallized	No	GBAA3921	47529213	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	237	Conserved; Essential;	Phase 3: June 2008	2P68	38.1%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02371 (show subtarget assignments)	1	expressed	No	CBU_1904	29542461	ftsE	cell division ABC transporter, ATP-bindi...	217	Conserved; Drug target functions	Phase 3: June 2008	1F3O	38.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02647 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0537	16802580		allantoate amidohydrolase [Listeria mono...	423	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3N5F	38.1%	Listeria monocytogenes	Energy metabolism	Amino acids and amines

IDP01141 (show subtarget assignments)	1	crystallized	No	BA_5155	56404588		Probable cytosol aminopeptidase (Leucine...	494	Drug Target Function	Phase 2: March 2008	3H8E	38.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05057 (show subtarget assignments)	1	cloned	No	CD0266	126697838	fliA	RNA polymerase sigma factor for flagella...	233	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	38.2%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90824 (show subtarget assignments)	8	purified	No	Cj0774c	15792112		ABC transporter ATP-binding protein [Cam...	336	Predicted Essential	Community Requests	3DHW	38.2%	Campylobacter jejuni

IDP04275 (show subtarget assignments)	1	cloned	No	BAS3684	49186683		DNA topoisomerase I [Bacillus anthracis ...	692	Proposed to be essential proteins	Phase 4: April 2009	2GAI	38.2%	Bacillus anthracis

IDP02412 (show subtarget assignments)	1	soluble	No	GBAA4760	47530059	etfB	electron transfer flavoprotein, beta sub...	257	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1EFP	38.2%	Bacillus anthracis	Energy metabolism	Electron transport

IDP04462 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1939	115347664		putative glutaminase [Yersinia pestis CO...	340	putative drug target function;	Phase 4: April 2009	1U60	38.2%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP05749 (show subtarget assignments)	1	cloned	No	Cj0775c	6968216	valS	putative periplasmic protein [Campylobac...	870	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	38.2%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP00309 (show subtarget assignments)	1	expressed	No	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01117 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3754	33301235		LexA repressor	206	Conserved Gene / Pathway	Phase 2: March 2008	3K2Z	38.3%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP90836 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0647	15792007		phosphatase, YrbI family [Campylobacter ...	162	Predicted Essential	Community Requests	2R8E	38.3%	Campylobacter jejuni

IDP02003 (show subtarget assignments)	1	cloned	No	YPO0190	16120529		glutathione-regulated potassium-efflux s...	183	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3EYW	38.3%	Yersinia pestis	Energy metabolism	Electron transport

IDP02392 (show subtarget assignments)	1	soluble	No	GBAA2294	47527593		hypothetical protein GBAA2294 [Bacillus ...	436	Conserved; Essential;	Phase 3: June 2008	3I4J	38.3%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01368 (show subtarget assignments)	1	soluble	No	VC0238	15640268		transferase, hexapeptide repeat family	188	Drug Target Function	Phase 2: March 2008	3JQY	38.3%	Vibrio cholerae	Central intermediary metabolism	Other

IDP01161 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4997	30259489		ABC transporter, ATP-binding protein	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00009 (show subtarget assignments)	1	soluble	No	BA_1538	38372188		3-dehydroquinate synthase	363	Drug Target Homolog	Phase 1: October 2007	1XAG	38.3%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02160 (show subtarget assignments)	1	soluble	No	CBU_1245	29541815		GTP-binding protein [Coxiella burnetii R...	443	Conserved; Drug target functions	Phase 3: June 2008	2HJG	38.4%	Coxiella burnetii	Unknown function	General

IDP02149 (show subtarget assignments)	1	cloned	No	Cj1428c	15792746	fcl	putative fucose synthetase [Campylobacte...	346	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1BSV	38.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02829 (show subtarget assignments)	1	cloned	No	GBAA4382	47529677	bfmbB	branched-chain alpha-keto acid dehydroge...	439	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.4%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP05323 (show subtarget assignments)	1	cloned	No	lmo1275	16803315	topA	DNA topoisomerase I [Listeria monocytoge...	692	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2GAI	38.4%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP04073 (show subtarget assignments)	1	crystallized	No	YPO0502	115346311		conserved hypothetical protein [Yersinia...	172	virulence factor; conserved gene;	Phase 4: April 2009	1Y12	38.4%	Yersinia pestis	Hypothetical proteins	Conserved

IDP05142 (show subtarget assignments)	1	cloned	No	BAS2027	49185038	-	isoleucyl-tRNA synthetase [Bacillus anth...	1033	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ILE	38.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP90921 (show subtarget assignments)	8	purified	No	YPO2984	16123165	gltX	glutamyl-tRNA synthetase [Yersinia pesti...	471	Predicted Essential	Community Requests	2CFO	38.4%	Yersinia pestis

IDP90814 (show subtarget assignments)	8	soluble	No	Cj0329c	15791697	plsX	putative glycerol-3-phosphate acyltransf...	328	Predicted Essential	Community Requests	1VI1	38.4%	Campylobacter jejuni

IDP04437 (show subtarget assignments)	1	cloned	No	YPO0023	115345855	glnR	Two component regulatory protein involve...	349	putative drug target function;	Phase 4: April 2009	1R62	38.4%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP01458 (show subtarget assignments)	1	soluble	No	VC2418	15642415		thiol:disulfide interchange protein DsbC...	250	Drug Target Function	Phase 2: March 2008	1JZD	38.4%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01196 (show subtarget assignments)	1	expressed	No	BA_1248	30255197	trpE	anthranilate synthase component I	471	Drug Target Function	Phase 2: March 2008	1QDL	38.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP90752 (show subtarget assignments)	8	soluble	No	Cj1098	15792423	pyrB	aspartate carbamoyltransferase catalytic...	295	Predicted Essential	Community Requests	2AT2	38.5%	Campylobacter jejuni

IDP04446 (show subtarget assignments)	1	cloned	No	YPO0653	115346457	glnE	glutamate-ammonia-ligase adenylyltransfe...	951	conserved gene; putative drug target function;	Phase 4: April 2009	3K7D	38.5%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP90864 (show subtarget assignments)	8	expressed	No	Cj0405	15791772	aroE	shikimate 5-dehydrogenase [Campylobacter...	262	Predicted Essential	Community Requests	3PHG	38.5%	Campylobacter jejuni

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP00442 (show subtarget assignments)	1	soluble	No	YPO2211	16122439	trpH	hypothetical protein YPO2211	299	Conserved Gene / Pathway	Phase 2: March 2008	2YB1	38.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP90787 (show subtarget assignments)	8	purified	No	Cj0838c	15792176	metG	methionyl-tRNA synthetase [Campylobacter...	628	Predicted Essential	Community Requests	2CSX	38.5%	Campylobacter jejuni

IDP05517 (show subtarget assignments)	1	soluble	No	CD1699	126699305	ribB	riboflavin synthase subunit alpha [Clost...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KZL	38.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91941 (show subtarget assignments)	8	selected	No	SpneCM_010100000177	298254016		ABC transporter, ATP-binding/permease pr...	588	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QF4	38.6%	Streptococcus pneumoniae

IDP90582 (show subtarget assignments)	8	soluble	No	Cj1686c	15792989	topA	DNA topoisomerase I [Campylobacter jejun...	700	Predicted Essential	Community Requests	2GAI	38.6%	Campylobacter jejuni

IDP02830 (show subtarget assignments)	1	soluble	No	GBAA4861	47530155	pepQ-2	proline dipeptidase [Bacillus anthracis ...	365	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WY2	38.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90536 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0187c	15791574	purN	phosphoribosylglycinamide formyltransfer...	188	Predicted Essential	Community Requests	1C2T	38.6%	Campylobacter jejuni

IDP02600
(show subtarget assignments)

1

expressed

No

STM2279

16765606

yfaE

2Fe-2S ferredoxin YfaE [Salmonella typhi...

84

Conserved; Drug target functions

Phase 3: June 2008

1IUE

37.2%

Salmonella enterica

Unknown function

General

IDP05409
(show subtarget assignments)

1

soluble

No

BA_2728

30257334

putative pullulanase [Bacillus anthracis...

852

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2WAN

37.2%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02213
(show subtarget assignments)

1

expressed

No

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP05217
(show subtarget assignments)

1

in_crystallization_trials

No

CD3421

126701044

hemC

porphobilinogen deaminase [Clostridium d...

301

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PDA

37.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01979
(show subtarget assignments)

1

purified

No

STM3458

16766747

yheR

glutathione-regulated potassium-efflux s...

183

Conserved; Drug target functions

Phase 3: June 2008

3EYW

37.2%

Salmonella enterica

Energy metabolism

Electron transport

IDP90589
(show subtarget assignments)

8

soluble

No

VC0296

15640324

acetyl-CoA carboxylase [Vibrio cholerae ...

196

Predicted Essential

Community Requests

1A6X

37.2%

Vibrio cholerae

IDP05626
(show subtarget assignments)

1

soluble

No

CD1430

126699034

putative exported polysaccharide deacety...

274

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1NY1

37.2%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP00004
(show subtarget assignments)

1

soluble

No

BA_0001

38257418

Chromosomal replication initiator protei...

446

Drug Target Homolog

Phase 1: October 2007

2Z4R

37.2%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP04685
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3438

47528724

alcohol dehydrogenase, zinc-containing [...

335

virulence factor; putative drug target function;

Phase 4: April 2009

3GAZ

37.3%

Bacillus anthracis

Energy metabolism

Fermentation

IDP01070
(show subtarget assignments)

1

expressed

No

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP00908
(show subtarget assignments)

1

expressed

No

STM0143

16763533

hofB

hypothetical protein STM0143

461

Conserved Gene / Pathway

Phase 2: March 2008

1P9R

37.3%

Salmonella enterica

Cell envelope

Surface structures

IDP04361
(show subtarget assignments)

1

soluble

No

YPO2803

218929869

bglB

putative beta-glucosidase [Yersinia pest...

793

drug target; putative drug target function;

Phase 4: April 2009

2X40

37.3%

Yersinia pestis

Energy metabolism

Sugars

IDP00544
(show subtarget assignments)

1

purified

No

YPO2746

16122950

fadI

3-ketoacyl-CoA thiolase

436

Virulence Associated Factor

Phase 2: March 2008

1ULQ

37.4%

Yersinia pestis

Cellular processes

Detoxification

IDP01934
(show subtarget assignments)

1

soluble

No

GBAA0385

47525656

chitinase B [Bacillus anthracis str. 'Am...

674

Drug target motif; Drug target functions

Phase 3: June 2008

1ITX

37.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02506
(show subtarget assignments)

1

soluble

No

FTT0609

56707734

peptidase, M24 family protein [Francisel...

597

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3CTZ

37.4%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00779
(show subtarget assignments)

1

purified

No

SACOL0691

57285661

sirR

iron-dependent repressor

214

Conserved Gene / Pathway

Phase 2: March 2008

3HRS

37.4%

Staphylococcus aureus

Regulatory functions

DNA interactions

IDP91972
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100003825

298254730

iron-compound ABC transporter, iron-comp...

321

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2CHU

37.4%

Streptococcus pneumoniae

IDP04168
(show subtarget assignments)

1

purified

No

VC2142

15642141

flagellin [Vibrio cholerae O1 biovar elt...

376

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3K8V

37.5%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP02753
(show subtarget assignments)

1

expressed

No

GBAA4662

47529960

nadB

L-aspartate oxidase [Bacillus anthracis ...

509

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CHU

37.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02697
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3029

47528319

succinylornithine transaminase, putative...

405

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

37.5%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP00752
(show subtarget assignments)

1

purified

No

SACOL2211

57284992

ABC transporter, ATP-binding protein

269

Drug Target Function

Phase 2: March 2008

3GFO

37.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00976
(show subtarget assignments)

1

in_crystallization_trials

No

STM1879

16765221

ptrB

protease 2

683

Drug Target Function

Phase 2: March 2008

2XE4

37.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02492
(show subtarget assignments)

1

crystallized

No

FTT1559c

56708586

proC

pyrroline-5-carboxylate reductase [Franc...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

37.6%

Francisella tularensis

Amino acid biosynthesis

Glutamate family

IDP02427
(show subtarget assignments)

1

purified

No

GBAA3553

47528837

pepF-2

oligoendopeptidase F [Bacillus anthracis...

595

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QR4

37.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01506
(show subtarget assignments)

1

in_crystallization_trials

No

VCA1113

15601861

spermidine/putrescine ABC transporter, p...

343

Conserved Gene / Pathway

Phase 2: March 2008

1POT

37.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90724
(show subtarget assignments)

8

expressed

No

Cj1719c

15793022

leuA

2-isopropylmalate synthase [Campylobacte...

511

Predicted Essential

Community Requests

3RMJ

37.6%

Campylobacter jejuni

IDP01303
(show subtarget assignments)

1

purified

No

VC0573

15640595

ubiquinol--cytochrome c reductase, iron-...

197

Conserved Gene / Pathway

Phase 2: March 2008

2FYN

37.6%

Vibrio cholerae

Energy metabolism

Electron transport

IDP02631
(show subtarget assignments)

1

expressed

No

GBAA1440

47526715

cysH

phosphoadenosine phosphosulfate reductas...

226

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GOY

37.6%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP90298
(show subtarget assignments)

8

selected

No

TGME49_120190

211967550

bradyzoite-specific surface protein, put...

398

TgSRS9 is one of the few in the SAG1 family that is expressed only in bradyzoite...

Community Requests

2JKS

37.7%

Toxoplasma gondii

IDP01825
(show subtarget assignments)

1

cloned

No

STM2265

16765593

ada

O6-methylguanine-DNA methyltransferase/t...

353

Conserved; Drug target functions

Phase 3: June 2008

1SFE

37.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01803
(show subtarget assignments)

1

soluble

No

CBU_0646

29541247

ribE

riboflavin synthase, alpha subunit [Coxi...

202

Conserved; Drug target functions

Phase 3: June 2008

1I8D

37.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00024
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0039

33516921

Dimethyladenosine transferase (S-adenosy...

292

Virulence

Phase 1: October 2007

3GRR

37.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01692
(show subtarget assignments)

1

cloned

No

FTT1671

56708681

ribD

riboflavin biosynthesis protein ribD [Fr...

355

Conserved; Drug target functions

Phase 3: June 2008

2B3Z

37.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00827
(show subtarget assignments)

1

expressed

No

SACOL2507

57285192

sarU

staphylococcal accessory regulator U

247

Conserved Gene / Pathway

Phase 2: March 2008

1P4X

37.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01644
(show subtarget assignments)

1

cloned

No

FTT0626

56707751

lon

DNA-binding, ATP-dependent protease La [...

774

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3M6A

37.7%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00637
(show subtarget assignments)

1

cloned

No

SACOL1727

57284738

infC

translation initiation factor IF-3

175

Drug Target Function

Phase 2: March 2008

1TIG

37.7%

Staphylococcus aureus

Protein synthesis

Translation factors

IDP05726
(show subtarget assignments)

1

soluble

No

BA_3927

30258439

lipoprotein, Bmp family [Bacillus anthra...

355

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

37.7%

Bacillus anthracis

Cell envelope: Other

IDP04373
(show subtarget assignments)

1

cloned

No

YPO3097

218930139

manB

phosphomannomutase [Yersinia pestis CO92...

457

drug target; virulence factor; putative drug target function;

Phase 4: April 2009

3UW2

37.8%

Yersinia pestis

Energy metabolism

Sugars

IDP05714
(show subtarget assignments)

1

purified

No

BA_0175

30253683

putative ABC transporter, substrate-bind...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3K2D

37.8%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP02706
(show subtarget assignments)

1

cloned

No

FTT0470

56707612

apaH

diadenosine tetraphosphatase [Francisell...

275

Drug Target

Phase 3: June 2008

2DFJ

37.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP01643
(show subtarget assignments)

1

crystallized

No

YPO2892

16123083

hscA

chaperone protein HscA [Yersinia pestis ...

650

CD; Drug target functions

Phase 3: June 2008

2KHO

37.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP00011
(show subtarget assignments)

1

soluble

No

BA_2222

30256868

alcohol dehydrogenase, iron-containing

392

Drug Target Homolog

Phase 1: October 2007

3OWO

37.8%

Bacillus anthracis

Energy metabolism

Fermentation

IDP01311
(show subtarget assignments)

1

soluble

No

VCA0726

15601482

molybdenum ABC transporter, periplasmic ...

254

Conserved Gene / Pathway

Phase 2: March 2008

1AMF

37.8%

Vibrio cholerae

Transport and binding proteins

Anions

IDP02629
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02787
(show subtarget assignments)

1

cloned

No

FTT0697

56707817

ftsI

penicillin binding protein (peptidoglyca...

564

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3OC2

37.9%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00039
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1960

30256617

aminoglycoside 6-adenylyltransferase, pu...

290

Virulence

Phase 1: October 2007

2PBE

37.9%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01354
(show subtarget assignments)

1

cloned

No

VC0003

15640035

trmE

tRNA modification GTPase TrmE

464

Conserved Gene / Pathway

Phase 2: March 2008

3GEH

37.9%

Vibrio cholerae

Cellular processes

Detoxification

IDP90650
(show subtarget assignments)

8

expressed

No

Cj0713

15792062

trmD

tRNA (guanine-N(1)-)-methyltransferase [...

234

Predicted Essential

Community Requests

3KY7

38%

Campylobacter jejuni

IDP91204
(show subtarget assignments)

8

cloned

No

BT_4215

29349623

shikimate 5-dehydrogenase [Bacteroides t...

248

potential drug target / Shikimate pathway enzyme

Community Requests

2HK7

38%

Bacteroides thetaiotaomicron

IDP91021
(show subtarget assignments)

8

cloned

No

y2872

22126749

yiuR

putative outer membrane receptor [Yersin...

665

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

2HDF

38%

Yersinia pestis

IDP00195
(show subtarget assignments)

1

cloned

No

YPO1009

16121311

-

probable peptidase

410

Similar to Essential SALTY

Phase 1: October 2007

1VIX

38%

Yersinia pestis

Hypothetical proteins

Conserved

IDP90697
(show subtarget assignments)

8

cloned

No

Cj0098

15791486

fmt

methionyl-tRNA formyltransferase [Campyl...

305

Predicted Essential

Community Requests

3R8X

38%

Campylobacter jejuni

IDP00758
(show subtarget assignments)

1

soluble

No

SACOL0140

57285343

cap5E

capsular polysaccharide biosynthesis pro...

342

Conserved Gene / Pathway

Phase 2: March 2008

2GN4

38%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02384
(show subtarget assignments)

1

expressed

No

GBAA3202

47528494

hscC

chaperone protein hscC [Bacillus anthrac...

566

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V7Y

38%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP00302
(show subtarget assignments)

1

expressed

No

CBU_1155

29654460

trpBF

N-(5'phosphoribosyl)anthranilate isomera...

600

Drug Target Function

Phase 2: March 2008

1V8Z

38%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01158
(show subtarget assignments)

1

expressed

No

BA_4669

30259165

ABC transporter, ATP-binding protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02596
(show subtarget assignments)

1

cloned

No

GBAA1269

47526536

odhB

dihydrolipoamide acetyltransferase [Baci...

418

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.1%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP00120
(show subtarget assignments)

1

expressed

No

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP91800
(show subtarget assignments)

8

in_crystallization_trials

No

p6418_01

219372022

sul2

dihydropteroate synthase [Escherichia co...

271

drug resistance / Deactivates antibiotic sulfonamide by ligating on p-aminobenzoic acid; we will c...

Community Requests

2Y5J

38.1%

Escherichia coli

IDP91192
(show subtarget assignments)

1

in_crystallization_trials

No

BAD95814

62857277

neoU

aminoglycoside 3'-phosphotransferase [St...

268

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R78

38.1%

Streptomyces fradiae

IDP02456
(show subtarget assignments)

1

crystallized

No

GBAA3921

47529213

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

237

Conserved; Essential;

Phase 3: June 2008

2P68

38.1%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02371
(show subtarget assignments)

1

expressed

No

CBU_1904

29542461

ftsE

cell division ABC transporter, ATP-bindi...

217

Conserved; Drug target functions

Phase 3: June 2008

1F3O

38.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02647
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0537

16802580

allantoate amidohydrolase [Listeria mono...

423

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3N5F

38.1%

Listeria monocytogenes

Energy metabolism

Amino acids and amines

IDP01141
(show subtarget assignments)

1

crystallized

No

BA_5155

56404588

Probable cytosol aminopeptidase (Leucine...

494

Drug Target Function

Phase 2: March 2008

3H8E

38.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05057
(show subtarget assignments)

1

cloned

No

CD0266

126697838

fliA

RNA polymerase sigma factor for flagella...

233

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

38.2%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90824
(show subtarget assignments)

8

purified

No

Cj0774c

15792112

ABC transporter ATP-binding protein [Cam...

336

Predicted Essential

Community Requests

3DHW

38.2%

Campylobacter jejuni

IDP04275
(show subtarget assignments)

1

cloned

No

BAS3684

49186683

DNA topoisomerase I [Bacillus anthracis ...

692

Proposed to be essential proteins

Phase 4: April 2009

2GAI

38.2%

Bacillus anthracis

IDP02412
(show subtarget assignments)

1

soluble

No

GBAA4760

47530059

etfB

electron transfer flavoprotein, beta sub...

257

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1EFP

38.2%

Bacillus anthracis

Energy metabolism

Electron transport

IDP04462
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1939

115347664

putative glutaminase [Yersinia pestis CO...

340

putative drug target function;

Phase 4: April 2009

1U60

38.2%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP05749
(show subtarget assignments)

1

cloned

No

Cj0775c

6968216

valS

putative periplasmic protein [Campylobac...

870

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

38.2%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP00309
(show subtarget assignments)

1

expressed

No

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01117
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3754

33301235

LexA repressor

206

Conserved Gene / Pathway

Phase 2: March 2008

3K2Z

38.3%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP90836
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0647

15792007

phosphatase, YrbI family [Campylobacter ...

162

Predicted Essential

Community Requests

2R8E

38.3%

Campylobacter jejuni

IDP02003
(show subtarget assignments)

1

cloned

No

YPO0190

16120529

glutathione-regulated potassium-efflux s...

183

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3EYW

38.3%

Yersinia pestis

Energy metabolism

Electron transport

IDP02392
(show subtarget assignments)

1

soluble

No

GBAA2294

47527593

hypothetical protein GBAA2294 [Bacillus ...

436

Conserved; Essential;

Phase 3: June 2008

3I4J

38.3%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01368
(show subtarget assignments)

1

soluble

No

VC0238

15640268

transferase, hexapeptide repeat family

188

Drug Target Function

Phase 2: March 2008

3JQY

38.3%

Vibrio cholerae

Central intermediary metabolism

Other

IDP01161
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4997

30259489

ABC transporter, ATP-binding protein

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00009
(show subtarget assignments)

1

soluble

No

BA_1538

38372188

3-dehydroquinate synthase

363

Drug Target Homolog

Phase 1: October 2007

1XAG

38.3%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02160
(show subtarget assignments)

1

soluble

No

CBU_1245

29541815

GTP-binding protein [Coxiella burnetii R...

443

Conserved; Drug target functions

Phase 3: June 2008

2HJG

38.4%

Coxiella burnetii

Unknown function

General

IDP02149
(show subtarget assignments)

1

cloned

No

Cj1428c

15792746

fcl

putative fucose synthetase [Campylobacte...

346

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1BSV

38.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02829
(show subtarget assignments)

1

cloned

No

GBAA4382

47529677

bfmbB

branched-chain alpha-keto acid dehydroge...

439

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.4%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP05323
(show subtarget assignments)

1

cloned

No

lmo1275

16803315

topA

DNA topoisomerase I [Listeria monocytoge...

692

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2GAI

38.4%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP04073
(show subtarget assignments)

1

crystallized

No

YPO0502

115346311

conserved hypothetical protein [Yersinia...

172

virulence factor; conserved gene;

Phase 4: April 2009

1Y12

38.4%

Yersinia pestis

Hypothetical proteins

Conserved

IDP05142
(show subtarget assignments)

1

cloned

No

BAS2027

49185038

-

isoleucyl-tRNA synthetase [Bacillus anth...

1033

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ILE

38.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP90921
(show subtarget assignments)

8

purified

No

YPO2984

16123165

gltX

glutamyl-tRNA synthetase [Yersinia pesti...

471

Predicted Essential

Community Requests

2CFO

38.4%

Yersinia pestis

IDP90814
(show subtarget assignments)

8

soluble

No

Cj0329c

15791697

plsX

putative glycerol-3-phosphate acyltransf...

328

Predicted Essential

Community Requests

1VI1

38.4%

Campylobacter jejuni

IDP04437
(show subtarget assignments)

1

cloned

No

YPO0023

115345855

glnR

Two component regulatory protein involve...

349

putative drug target function;

Phase 4: April 2009

1R62

38.4%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP01458
(show subtarget assignments)

1

soluble

No

VC2418

15642415

thiol:disulfide interchange protein DsbC...

250

Drug Target Function

Phase 2: March 2008

1JZD

38.4%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01196
(show subtarget assignments)

1

expressed

No

BA_1248

30255197

trpE

anthranilate synthase component I

471

Drug Target Function

Phase 2: March 2008

1QDL

38.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP90752
(show subtarget assignments)

8

soluble

No

Cj1098

15792423

pyrB

aspartate carbamoyltransferase catalytic...

295

Predicted Essential

Community Requests

2AT2

38.5%

Campylobacter jejuni

IDP04446
(show subtarget assignments)

1

cloned

No

YPO0653

115346457

glnE

glutamate-ammonia-ligase adenylyltransfe...

951

conserved gene; putative drug target function;

Phase 4: April 2009

3K7D

38.5%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP90864
(show subtarget assignments)

8

expressed

No

Cj0405

15791772

aroE

shikimate 5-dehydrogenase [Campylobacter...

262

Predicted Essential

Community Requests

3PHG

38.5%

Campylobacter jejuni

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP00442
(show subtarget assignments)

1

soluble

No

YPO2211

16122439

trpH

hypothetical protein YPO2211

299

Conserved Gene / Pathway

Phase 2: March 2008

2YB1

38.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP90787
(show subtarget assignments)

8

purified

No

Cj0838c

15792176

metG

methionyl-tRNA synthetase [Campylobacter...

628

Predicted Essential

Community Requests

2CSX

38.5%

Campylobacter jejuni

IDP05517
(show subtarget assignments)

1

soluble

No

CD1699

126699305

ribB

riboflavin synthase subunit alpha [Clost...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KZL

38.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91941
(show subtarget assignments)

8

selected

No

SpneCM_010100000177

298254016

ABC transporter, ATP-binding/permease pr...

588

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QF4

38.6%

Streptococcus pneumoniae

IDP90582
(show subtarget assignments)

8

soluble

No

Cj1686c

15792989

topA

DNA topoisomerase I [Campylobacter jejun...

700

Predicted Essential

Community Requests

2GAI

38.6%

Campylobacter jejuni

IDP02830
(show subtarget assignments)

1

soluble

No

GBAA4861

47530155

pepQ-2

proline dipeptidase [Bacillus anthracis ...

365

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WY2

38.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90536
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0187c

15791574

purN

phosphoribosylglycinamide formyltransfer...

188

Predicted Essential

Community Requests

1C2T

38.6%

Campylobacter jejuni