Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02230 (show subtarget assignments)	1	cloned	No	YPO0829	16121138		putative sulfatase [Yersinia pestis CO92...	517	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2QZU	40.2%	Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP90147 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_194	68449266		kelch-like protein [Monkeypox virus]	70	similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R	Community Requests	2Q81	31.4%	Monkeypox virus

IDP05118 (show subtarget assignments)	1	cloned	No	Z5902	12519310		putative helicase [Escherichia coli O157...	704	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	12.8%	Escherichia coli	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05125 (show subtarget assignments)	1	cloned	No	BA_4310	30258811		putative lipoprotein [Bacillus anthracis...	246	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP02234 (show subtarget assignments)	1	cloned	No	FTT1094c	56708177		cytosol aminopeptidase family protein [F...	471	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IJ3	41.1%	Francisella tularensis	N/A	N/A

IDP02599 (show subtarget assignments)	1	cloned	No	Cj1138	15792463		putative galactosyltransferase [Campylob...	389	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	22%	Campylobacter jejuni	Energy metabolism	Sugars

IDP90423 (show subtarget assignments)	8	cloned	No	CT_444	3328876	omcA	9kDa-Cysteine-Rich Lipoprotein [Chlamydi...	88	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP01240 (show subtarget assignments)	1	cloned	No	BA_1069	30254800	pbpF	penicillin-binding protein 1	705	Drug Target Function	Phase 2: March 2008	2OLU	27.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00648 (show subtarget assignments)	1	cloned	No	SACOL2160	57286373		hemolysin III, putative	227	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90424 (show subtarget assignments)	8	cloned	No	CT_546	3328985		predicted OMP [Chlamydia trachomatis D/U...	289	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP02242 (show subtarget assignments)	1	cloned	No	Cj0320	15791688	fliH	flagellar assembly protein H [Campylobac...	276	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02243 (show subtarget assignments)	1	cloned	No	YPO0834	16121142	manX	putative PTS transport protein [Yersinia...	165	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3EYE	41.8%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90420 (show subtarget assignments)	8	cloned	No	CT_465	3328899		hypothetical protein [Chlamydia trachoma...	213	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP90419 (show subtarget assignments)	8	cloned	No	CT_446	3328878	euo	CHLPS Euo Protein [Chlamydia trachomatis...	183	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90174 (show subtarget assignments)	8	cloned	No	AAM13466.1	20153005	CPXV019 CDS	CPXV019 protein	796	ankyrin repeat protein	Community Requests	3HG0	3.8%	Cowpox virus	conserved hypothetical proteins	0

IDP90422 (show subtarget assignments)	8	cloned	No	CT_471	3328905		hypothetical protein [Chlamydia trachoma...	200	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90426 (show subtarget assignments)	8	cloned	No	CT_863	3329337		hypothetical protein [Chlamydia trachoma...	482	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02759 (show subtarget assignments)	1	cloned	No	YPO0102	16120449		hypothetical protein YPO0102 [Yersinia p...	194	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP02251 (show subtarget assignments)	1	cloned	No	YPO1201	16121494		putative amino acid decarboxylase [Yersi...	768	Involved in virulence; Drug target functions	Phase 3: June 2008	2VYC	51.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP05115 (show subtarget assignments)	1	cloned	No	CD2567	126700186		PTS system, IIB component [Clostridium d...	102	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2R48	43.1%	Clostridium difficile	Signal transduction: PTS

IDP90413 (show subtarget assignments)	8	cloned	No	CT_622	3329069		CHLPN 76kDa Homolog [Chlamydia trachomat...	647	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02254 (show subtarget assignments)	1	cloned	No	FTT0766	56707880	deoD	purine nucleoside phosphorylase [Francis...	240	Drug Target	Phase 3: June 2008	1VHJ	43.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02255 (show subtarget assignments)	1	cloned	No	FTT1130c	56708207	cphA	cyanophycin synthetase [Francisella tula...	940	Drug Target	Phase 3: June 2008	2WTZ	13.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP02632 (show subtarget assignments)	1	cloned	No	lmo0582	16802625	iap	P60 extracellular protein, invasion asso...	482	Known virulence-Invasion; Possible Vaccine Candidate; Known Essential Genes; PMI...	Phase 3: June 2008	3H41	14.1%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP00142 (show subtarget assignments)	1	cloned	No	VC1456	15641467	ctxB	cholera enterotoxin, B subunit	124	Virulence	Phase 1: October 2007	1EEI	81.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP04321 (show subtarget assignments)	1	cloned	No	VC0756	15640775	ndk	nucleoside diphosphate kinase [Vibrio ch...	142	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2HUR	64.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02259 (show subtarget assignments)	1	cloned	No	GBAA2164	47527458		ABC transporter ATP-binding protein [Bac...	631	Conserved; Drug target functions	Phase 3: June 2008	1YQT	21.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP90415 (show subtarget assignments)	8	cloned	No	CT_443	3328874	omcB	60kDa Cysteine-Rich OMP [Chlamydia trach...	553	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP05129 (show subtarget assignments)	1	cloned	No	CD0091	126697661	adk	adenylate kinase [Clostridium difficile ...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3FB4	57.9%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04322 (show subtarget assignments)	1	cloned	No	VC1001	15641016		folylpolyglutamate synthase/dihydrofolat...	421	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N2A	53.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02265 (show subtarget assignments)	1	cloned	No	YPO1303	16121585	psaA	pH 6 antigen precursor (antigen 4) (adhe...	158	Involved in virulence; Vaccine TargetDrug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP05142 (show subtarget assignments)	1	cloned	No	BAS2027	49185038	-	isoleucyl-tRNA synthetase [Bacillus anth...	1033	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ILE	38.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05055 (show subtarget assignments)	1	cloned	No	CD0253	126697824	fliK	putative flagellar hook-length control p...	401	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02745 (show subtarget assignments)	1	cloned	No	GBAA4384	47529679	bfmbAa	3-methyl-2-oxobutanoate dehydrogenase, a...	333	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	41.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP00318 (show subtarget assignments)	1	cloned	No	CBU_1947	29655231	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Drug Target Function	Phase 2: March 2008	1HV9	51.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05117 (show subtarget assignments)	1	cloned	No	CD2831	126700447		putative collagen-binding protein [Clost...	972	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3KPT	9.3%	Clostridium difficile	Unknown function: General

IDP90405 (show subtarget assignments)	8	cloned	No	CT_651	3329100		hypothetical protein [Chlamydia trachoma...	608	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90417 (show subtarget assignments)	8	cloned	No	CT_504	3328941		hypothetical protein [Chlamydia trachoma...	288	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90183 (show subtarget assignments)	8	cloned	No	AAM13482.1	20153021	CPXV035 CDS	CPXV035 protein	512	kelch-like protein	Community Requests	2XN4	12.7%	Cowpox virus	conserved hypothetical proteins	0

IDP90427 (show subtarget assignments)	8	cloned	No	CT_847	3329319		hypothetical protein [Chlamydia trachoma...	172	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02275 (show subtarget assignments)	1	cloned	No	FTT1158c	56708229		Type IV pili glycosylation protein [Fran...	198	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008			Francisella tularensis	Cell envelopeCellular processes	Surface structuresPathogenesis,Cell adhesion

IDP90528 (show subtarget assignments)	8	cloned	No	VCA1063	15601814		ornithine decarboxylase [Vibrio cholerae...	720	Predicted Essential	Community Requests	1ORD	59.1%	Vibrio cholerae

IDP04310 (show subtarget assignments)	1	cloned	No	BAS0231	49183264		D-alanine--D-alanine ligase, C-terminus ...	91	Proposed to be essential proteins	Phase 4: April 2009	2I80	54.9%	Bacillus anthracis

IDP00317 (show subtarget assignments)	1	cloned	No	CBU_1887	29655172	ponA	penicillin-binding protein 1A	793	Drug Target Function	Phase 2: March 2008	3UDF	40.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05110 (show subtarget assignments)	1	cloned	No	CD2184	126699800		N-acetylmuramoyl-L-alanine amidase (cell...	180	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3QAY	57.8%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00639 (show subtarget assignments)	1	cloned	No	SACOL0114	57286663		capsular polysaccharide biosynthesis gly...	230	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90393 (show subtarget assignments)	8	cloned	No	CT_567	3329008		hypothetical protein [Chlamydia trachoma...	174	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02743 (show subtarget assignments)	1	cloned	No	GBAA4383	47529678	bfmbAb	3-methyl-2-oxobutanoate dehydrogenase, b...	327	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	52.9%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04307 (show subtarget assignments)	1	cloned	No	CPF_1812	110799901		putative lipoprotein [Clostridium perfri...	44	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens

IDP90389 (show subtarget assignments)	8	cloned	No	CT_384	3328809		hypothetical protein [Chlamydia trachoma...	539	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04308 (show subtarget assignments)	1	cloned	No	YPCD1.14n	40548797		hypothetical protein YPCD1.14n [Yersinia...	65	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP00637 (show subtarget assignments)	1	cloned	No	SACOL1727	57284738	infC	translation initiation factor IF-3	175	Drug Target Function	Phase 2: March 2008	1TIG	37.7%	Staphylococcus aureus	Protein synthesis	Translation factors

IDP05111 (show subtarget assignments)	1	cloned	No	CD2187	126699803		putative phage-related cell wall hydrola...	297	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	21.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90390 (show subtarget assignments)	8	cloned	No	CT_377	3328802	ltuA	hypothetical protein [Chlamydia trachoma...	46	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90395 (show subtarget assignments)	8	cloned	No	CT_573	3329014		hypothetical protein [Chlamydia trachoma...	409	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90381 (show subtarget assignments)	8	cloned	No	CT_309	3328725		hypothetical protein [Chlamydia trachoma...	266	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00636 (show subtarget assignments)	1	cloned	No	SACOL1118	57285904	typA	GTP-binding protein TypA	615	Drug Target Function	Phase 2: March 2008	3E3X	27.6%	Staphylococcus aureus	Unknown function	General

IDP90383 (show subtarget assignments)	8	cloned	No	CT_412	3328840	pmpA	Putative outer membrane protein A [Chlam...	975	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP05106 (show subtarget assignments)	1	cloned	No	CD1469	126699073		cell surface protein (putative penicilli...	990	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2QMI	10%	Clostridium difficile	Cell envelope: Other

IDP00635 (show subtarget assignments)	1	cloned	No	SACOL2270	57286396	modC	molybdenum ABC transporter, ATP-binding ...	201	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	38.8%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP90379 (show subtarget assignments)	8	cloned	No	CT_330	3328749		hypothetical protein [Chlamydia trachoma...	90	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90385 (show subtarget assignments)	8	cloned	No	CT_392	3328818	yprS	hypothetical protein [Chlamydia trachoma...	377	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90369 (show subtarget assignments)	8	cloned	No	CT_181	3328585		hypothetical protein [Chlamydia trachoma...	236	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02738 (show subtarget assignments)	1	cloned	No	FTT1310c	56708367	hflB	ATP-dependent metalloprotease [Francisel...	638	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2DHR	39.3%	Francisella tularensis	N/A	N/A

IDP90371 (show subtarget assignments)	8	cloned	No	CT_109	3328506		CHLPS hypothetical protein [Chlamydia tr...	262	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP05109 (show subtarget assignments)	1	cloned	No	CD1987	126699595		cell surface protein [Clostridium diffic...	478	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP02438 (show subtarget assignments)	1	cloned	No	CBU_0029	29540654		acyltransferase family protein [Coxiella...	242	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP05112 (show subtarget assignments)	1	cloned	No	CD2246	126699864	cspC	putative germination-specific protease [...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3EIF	22.3%	Clostridium difficile	Unknown function: General

IDP90378 (show subtarget assignments)	8	cloned	No	CT_303	3328719		hypothetical protein [Chlamydia trachoma...	171	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90388 (show subtarget assignments)	8	cloned	No	CT_619	3329065		hypothetical protein [Chlamydia trachoma...	877	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90401 (show subtarget assignments)	8	cloned	No	CT_579	3329021		hypothetical protein [Chlamydia trachoma...	439	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3V47	14.8%	Chlamydia trachomatis

IDP02732 (show subtarget assignments)	1	cloned	No	CBU_1982	29542537	ksgA	dimethyladenosine transferase [Coxiella ...	255	Conserved; Drug target functions	Phase 3: June 2008	3TQS	100%	Coxiella burnetii	Protein synthesis	tRNA and rRNA base modification

IDP02744 (show subtarget assignments)	1	cloned	No	FTT0087	56707265	acnA	aconitate hydratase [Francisella tularen...	937	Drug Target	Phase 3: June 2008	3SN2	50.5%	Francisella tularensis	Energy metabolism	TCA cycle

IDP90359 (show subtarget assignments)	8	cloned	No	CT794.1	15605528		hypothetical protein CT794.1 [Chlamydia ...	95	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02734 (show subtarget assignments)	1	cloned	No	GBAA1779	47527069		thioredoxin family protein [Bacillus ant...	184	Drug target motif; Drug target functions	Phase 3: June 2008	1ST9	27.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP00630 (show subtarget assignments)	1	cloned	No	SACOL0861	57284322		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	2I5M	71.2%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP05082 (show subtarget assignments)	1	cloned	No	lmo2179	16804218	-	peptidoglycan binding protein [Listeria ...	1152	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KT7	2.3%	Listeria monocytogenes	Regulatory functions: Other

IDP90361 (show subtarget assignments)	8	cloned	No	CT_021	3328411		hypothetical protein [Chlamydia trachoma...	247	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02436 (show subtarget assignments)	1	cloned	No	Cj1418c	15792736		hypothetical protein Cj1418c [Campylobac...	779	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Energy metabolism	Electron transport

IDP05104 (show subtarget assignments)	1	cloned	No	CD1233	126698829		cell surface protein [Clostridium diffic...	475	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP90356 (show subtarget assignments)	8	cloned	No	CT080	15604799	ltuB	late transcription unit B protein [Chlam...	97	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02439 (show subtarget assignments)	1	cloned	No	GBAA3892	47529180		serine protease [Bacillus anthracis str....	613	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2OXA	16.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00628 (show subtarget assignments)	1	cloned	No	SACOL0369	57285482		prophage L54a, Clp protease, putative	257	Drug Target Function	Phase 2: March 2008	1Y7O	22.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05102 (show subtarget assignments)	1	cloned	No	CD1130	126698724		putative transglycosylase [Clostridium d...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1QSA	28.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90363 (show subtarget assignments)	8	cloned	No	CT_066	3328460		hypothetical protein [Chlamydia trachoma...	158	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02633 (show subtarget assignments)	1	cloned	No	Cj1431c	15792749		hypothetical protein Cj1431c [Campylobac...	582	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02723 (show subtarget assignments)	1	cloned	No	FTT0039	56707219	nuoI	NADH dehydrogenase subunit I [Francisell...	162	Conserved; Drug target functions	Phase 3: June 2008	2FUG	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP04317 (show subtarget assignments)	1	cloned	No	YPO0512	218927711		putative lipoprotein [Yersinia pestis CO...	163	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP01200 (show subtarget assignments)	1	cloned	No	BA_1707	30255995		transglycosylase, SLT family	261	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00626 (show subtarget assignments)	1	cloned	No	SACOL2506	57285191	sarT	staphylococcal accessory regulator T	118	Conserved Gene / Pathway	Phase 2: March 2008	2FNP	33.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP02726 (show subtarget assignments)	1	cloned	No	GBAA4229	47529522		maltosaccharide ABC transporter, maltosa...	419	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZYK	41.5%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90350 (show subtarget assignments)	8	cloned	No	CT456	15605183		hypothetical protein CT456 [Chlamydia tr...	1005	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02736 (show subtarget assignments)	1	cloned	No	GBAA4352	47778283	argD	acetylornithine aminotransferase [Bacill...	386	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	44%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02230
(show subtarget assignments)

1

cloned

No

YPO0829

16121138

putative sulfatase [Yersinia pestis CO92...

517

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2QZU

40.2%

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP90147
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_194

68449266

kelch-like protein [Monkeypox virus]

70

similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R

Community Requests

2Q81

31.4%

Monkeypox virus

IDP05118
(show subtarget assignments)

1

cloned

No

Z5902

12519310

putative helicase [Escherichia coli O157...

704

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

12.8%

Escherichia coli

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05125
(show subtarget assignments)

1

cloned

No

BA_4310

30258811

putative lipoprotein [Bacillus anthracis...

246

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP02234
(show subtarget assignments)

1

cloned

No

FTT1094c

56708177

cytosol aminopeptidase family protein [F...

471

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IJ3

41.1%

Francisella tularensis

N/A

IDP02599
(show subtarget assignments)

1

cloned

No

Cj1138

15792463

putative galactosyltransferase [Campylob...

389

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

22%

Campylobacter jejuni

Energy metabolism

Sugars

IDP90423
(show subtarget assignments)

8

cloned

No

CT_444

3328876

omcA

9kDa-Cysteine-Rich Lipoprotein [Chlamydi...

88

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP01240
(show subtarget assignments)

1

cloned

No

BA_1069

30254800

pbpF

penicillin-binding protein 1

705

Drug Target Function

Phase 2: March 2008

2OLU

27.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00648
(show subtarget assignments)

1

cloned

No

SACOL2160

57286373

hemolysin III, putative

227

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90424
(show subtarget assignments)

8

cloned

No

CT_546

3328985

predicted OMP [Chlamydia trachomatis D/U...

289

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP02242
(show subtarget assignments)

1

cloned

No

Cj0320

15791688

fliH

flagellar assembly protein H [Campylobac...

276

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02243
(show subtarget assignments)

1

cloned

No

YPO0834

16121142

manX

putative PTS transport protein [Yersinia...

165

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3EYE

41.8%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90420
(show subtarget assignments)

8

cloned

No

CT_465

3328899

hypothetical protein [Chlamydia trachoma...

213

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP90419
(show subtarget assignments)

8

cloned

No

CT_446

3328878

euo

CHLPS Euo Protein [Chlamydia trachomatis...

183

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90174
(show subtarget assignments)

8

cloned

No

AAM13466.1

20153005

CPXV019 CDS

CPXV019 protein

796

ankyrin repeat protein

Community Requests

3HG0

3.8%

Cowpox virus

conserved hypothetical proteins

0

IDP90422
(show subtarget assignments)

8

cloned

No

CT_471

3328905

hypothetical protein [Chlamydia trachoma...

200

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90426
(show subtarget assignments)

8

cloned

No

CT_863

3329337

hypothetical protein [Chlamydia trachoma...

482

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02759
(show subtarget assignments)

1

cloned

No

YPO0102

16120449

hypothetical protein YPO0102 [Yersinia p...

194

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP02251
(show subtarget assignments)

1

cloned

No

YPO1201

16121494

putative amino acid decarboxylase [Yersi...

768

Involved in virulence; Drug target functions

Phase 3: June 2008

2VYC

51.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP05115
(show subtarget assignments)

1

cloned

No

CD2567

126700186

PTS system, IIB component [Clostridium d...

102

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2R48

43.1%

Clostridium difficile

Signal transduction: PTS

IDP90413
(show subtarget assignments)

8

cloned

No

CT_622

3329069

CHLPN 76kDa Homolog [Chlamydia trachomat...

647

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02254
(show subtarget assignments)

1

cloned

No

FTT0766

56707880

deoD

purine nucleoside phosphorylase [Francis...

240

Drug Target

Phase 3: June 2008

1VHJ

43.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02255
(show subtarget assignments)

1

cloned

No

FTT1130c

56708207

cphA

cyanophycin synthetase [Francisella tula...

940

Drug Target

Phase 3: June 2008

2WTZ

13.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP02632
(show subtarget assignments)

1

cloned

No

lmo0582

16802625

iap

P60 extracellular protein, invasion asso...

482

Known virulence-Invasion; Possible Vaccine Candidate; Known Essential Genes; PMI...

Phase 3: June 2008

3H41

14.1%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP00142
(show subtarget assignments)

1

cloned

No

VC1456

15641467

ctxB

cholera enterotoxin, B subunit

124

Virulence

Phase 1: October 2007

1EEI

81.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP04321
(show subtarget assignments)

1

cloned

No

VC0756

15640775

ndk

nucleoside diphosphate kinase [Vibrio ch...

142

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2HUR

64.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02259
(show subtarget assignments)

1

cloned

No

GBAA2164

47527458

ABC transporter ATP-binding protein [Bac...

631

Conserved; Drug target functions

Phase 3: June 2008

1YQT

21.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP90415
(show subtarget assignments)

8

cloned

No

CT_443

3328874

omcB

60kDa Cysteine-Rich OMP [Chlamydia trach...

553

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP05129
(show subtarget assignments)

1

cloned

No

CD0091

126697661

adk

adenylate kinase [Clostridium difficile ...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3FB4

57.9%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04322
(show subtarget assignments)

1

cloned

No

VC1001

15641016

folylpolyglutamate synthase/dihydrofolat...

421

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N2A

53.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02265
(show subtarget assignments)

1

cloned

No

YPO1303

16121585

psaA

pH 6 antigen precursor (antigen 4) (adhe...

158

Involved in virulence; Vaccine TargetDrug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP05142
(show subtarget assignments)

1

cloned

No

BAS2027

49185038

-

isoleucyl-tRNA synthetase [Bacillus anth...

1033

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ILE

38.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05055
(show subtarget assignments)

1

cloned

No

CD0253

126697824

fliK

putative flagellar hook-length control p...

401

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02745
(show subtarget assignments)

1

cloned

No

GBAA4384

47529679

bfmbAa

3-methyl-2-oxobutanoate dehydrogenase, a...

333

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

41.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP00318
(show subtarget assignments)

1

cloned

No

CBU_1947

29655231

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Drug Target Function

Phase 2: March 2008

1HV9

51.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05117
(show subtarget assignments)

1

cloned

No

CD2831

126700447

putative collagen-binding protein [Clost...

972

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3KPT

9.3%

Clostridium difficile

Unknown function: General

IDP90405
(show subtarget assignments)

8

cloned

No

CT_651

3329100

hypothetical protein [Chlamydia trachoma...

608

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90417
(show subtarget assignments)

8

cloned

No

CT_504

3328941

hypothetical protein [Chlamydia trachoma...

288

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90183
(show subtarget assignments)

8

cloned

No

AAM13482.1

20153021

CPXV035 CDS

CPXV035 protein

512

kelch-like protein

Community Requests

2XN4

12.7%

Cowpox virus

conserved hypothetical proteins

0

IDP90427
(show subtarget assignments)

8

cloned

No

CT_847

3329319

hypothetical protein [Chlamydia trachoma...

172

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02275
(show subtarget assignments)

1

cloned

No

FTT1158c

56708229

Type IV pili glycosylation protein [Fran...

198

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

Francisella tularensis

Cell envelopeCellular processes

Surface structuresPathogenesis,Cell adhesion

IDP90528
(show subtarget assignments)

8

cloned

No

VCA1063

15601814

ornithine decarboxylase [Vibrio cholerae...

720

Predicted Essential

Community Requests

1ORD

59.1%

Vibrio cholerae

IDP04310
(show subtarget assignments)

1

cloned

No

BAS0231

49183264

D-alanine--D-alanine ligase, C-terminus ...

91

Proposed to be essential proteins

Phase 4: April 2009

2I80

54.9%

Bacillus anthracis

IDP00317
(show subtarget assignments)

1

cloned

No

CBU_1887

29655172

ponA

penicillin-binding protein 1A

793

Drug Target Function

Phase 2: March 2008

3UDF

40.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05110
(show subtarget assignments)

1

cloned

No

CD2184

126699800

N-acetylmuramoyl-L-alanine amidase (cell...

180

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3QAY

57.8%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00639
(show subtarget assignments)

1

cloned

No

SACOL0114

57286663

capsular polysaccharide biosynthesis gly...

230

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90393
(show subtarget assignments)

8

cloned

No

CT_567

3329008

hypothetical protein [Chlamydia trachoma...

174

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02743
(show subtarget assignments)

1

cloned

No

GBAA4383

47529678

bfmbAb

3-methyl-2-oxobutanoate dehydrogenase, b...

327

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

52.9%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04307
(show subtarget assignments)

1

cloned

No

CPF_1812

110799901

putative lipoprotein [Clostridium perfri...

44

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

IDP90389
(show subtarget assignments)

8

cloned

No

CT_384

3328809

hypothetical protein [Chlamydia trachoma...

539

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04308
(show subtarget assignments)

1

cloned

No

YPCD1.14n

40548797

hypothetical protein YPCD1.14n [Yersinia...

65

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP00637
(show subtarget assignments)

1

cloned

No

SACOL1727

57284738

infC

translation initiation factor IF-3

175

Drug Target Function

Phase 2: March 2008

1TIG

37.7%

Staphylococcus aureus

Protein synthesis

Translation factors

IDP05111
(show subtarget assignments)

1

cloned

No

CD2187

126699803

putative phage-related cell wall hydrola...

297

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

21.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90390
(show subtarget assignments)

8

cloned

No

CT_377

3328802

ltuA

hypothetical protein [Chlamydia trachoma...

46

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90395
(show subtarget assignments)

8

cloned

No

CT_573

3329014

hypothetical protein [Chlamydia trachoma...

409

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90381
(show subtarget assignments)

8

cloned

No

CT_309

3328725

hypothetical protein [Chlamydia trachoma...

266

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00636
(show subtarget assignments)

1

cloned

No

SACOL1118

57285904

typA

GTP-binding protein TypA

615

Drug Target Function

Phase 2: March 2008

3E3X

27.6%

Staphylococcus aureus

Unknown function

General

IDP90383
(show subtarget assignments)

8

cloned

No

CT_412

3328840

pmpA

Putative outer membrane protein A [Chlam...

975

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP05106
(show subtarget assignments)

1

cloned

No

CD1469

126699073

cell surface protein (putative penicilli...

990

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2QMI

10%

Clostridium difficile

Cell envelope: Other

IDP00635
(show subtarget assignments)

1

cloned

No

SACOL2270

57286396

modC

molybdenum ABC transporter, ATP-binding ...

201

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

38.8%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP90379
(show subtarget assignments)

8

cloned

No

CT_330

3328749

hypothetical protein [Chlamydia trachoma...

90

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90385
(show subtarget assignments)

8

cloned

No

CT_392

3328818

yprS

hypothetical protein [Chlamydia trachoma...

377

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90369
(show subtarget assignments)

8

cloned

No

CT_181

3328585

hypothetical protein [Chlamydia trachoma...

236

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02738
(show subtarget assignments)

1

cloned

No

FTT1310c

56708367

hflB

ATP-dependent metalloprotease [Francisel...

638

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2DHR

39.3%

Francisella tularensis

N/A

IDP90371
(show subtarget assignments)

8

cloned

No

CT_109

3328506

CHLPS hypothetical protein [Chlamydia tr...

262

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP05109
(show subtarget assignments)

1

cloned

No

CD1987

126699595

cell surface protein [Clostridium diffic...

478

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP02438
(show subtarget assignments)

1

cloned

No

CBU_0029

29540654

acyltransferase family protein [Coxiella...

242

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP05112
(show subtarget assignments)

1

cloned

No

CD2246

126699864

cspC

putative germination-specific protease [...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3EIF

22.3%

Clostridium difficile

Unknown function: General

IDP90378
(show subtarget assignments)

8

cloned

No

CT_303

3328719

hypothetical protein [Chlamydia trachoma...

171

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90388
(show subtarget assignments)

8

cloned

No

CT_619

3329065

hypothetical protein [Chlamydia trachoma...

877

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90401
(show subtarget assignments)

8

cloned

No

CT_579

3329021

hypothetical protein [Chlamydia trachoma...

439

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3V47

14.8%

Chlamydia trachomatis

IDP02732
(show subtarget assignments)

1

cloned

No

CBU_1982

29542537

ksgA

dimethyladenosine transferase [Coxiella ...

255

Conserved; Drug target functions

Phase 3: June 2008

3TQS

100%

Coxiella burnetii

Protein synthesis

tRNA and rRNA base modification

IDP02744
(show subtarget assignments)

1

cloned

No

FTT0087

56707265

acnA

aconitate hydratase [Francisella tularen...

937

Drug Target

Phase 3: June 2008

3SN2

50.5%

Francisella tularensis

Energy metabolism

TCA cycle

IDP90359
(show subtarget assignments)

8

cloned

No

CT794.1

15605528

hypothetical protein CT794.1 [Chlamydia ...

95

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02734
(show subtarget assignments)

1

cloned

No

GBAA1779

47527069

thioredoxin family protein [Bacillus ant...

184

Drug target motif; Drug target functions

Phase 3: June 2008

1ST9

27.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP00630
(show subtarget assignments)

1

cloned

No

SACOL0861

57284322

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

2I5M

71.2%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP05082
(show subtarget assignments)

1

cloned

No

lmo2179

16804218

-

peptidoglycan binding protein [Listeria ...

1152

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KT7

2.3%

Listeria monocytogenes

Regulatory functions: Other

IDP90361
(show subtarget assignments)

8

cloned

No

CT_021

3328411

hypothetical protein [Chlamydia trachoma...

247

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02436
(show subtarget assignments)

1

cloned

No

Cj1418c

15792736

hypothetical protein Cj1418c [Campylobac...

779

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Energy metabolism

Electron transport

IDP05104
(show subtarget assignments)

1

cloned

No

CD1233

126698829

cell surface protein [Clostridium diffic...

475

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP90356
(show subtarget assignments)

8

cloned

No

CT080

15604799

ltuB

late transcription unit B protein [Chlam...

97

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02439
(show subtarget assignments)

1

cloned

No

GBAA3892

47529180

serine protease [Bacillus anthracis str....

613

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2OXA

16.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00628
(show subtarget assignments)

1

cloned

No

SACOL0369

57285482

prophage L54a, Clp protease, putative

257

Drug Target Function

Phase 2: March 2008

1Y7O

22.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05102
(show subtarget assignments)

1

cloned

No

CD1130

126698724

putative transglycosylase [Clostridium d...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1QSA

28.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90363
(show subtarget assignments)

8

cloned

No

CT_066

3328460

hypothetical protein [Chlamydia trachoma...

158

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02633
(show subtarget assignments)

1

cloned

No

Cj1431c

15792749

hypothetical protein Cj1431c [Campylobac...

582

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02723
(show subtarget assignments)

1

cloned

No

FTT0039

56707219

nuoI

NADH dehydrogenase subunit I [Francisell...

162

Conserved; Drug target functions

Phase 3: June 2008

2FUG

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP04317
(show subtarget assignments)

1

cloned

No

YPO0512

218927711

putative lipoprotein [Yersinia pestis CO...

163

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP01200
(show subtarget assignments)

1

cloned

No

BA_1707

30255995

transglycosylase, SLT family

261

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00626
(show subtarget assignments)

1

cloned

No

SACOL2506

57285191

sarT

staphylococcal accessory regulator T

118

Conserved Gene / Pathway

Phase 2: March 2008

2FNP

33.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP02726
(show subtarget assignments)

1

cloned

No

GBAA4229

47529522

maltosaccharide ABC transporter, maltosa...

419

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZYK

41.5%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90350
(show subtarget assignments)

8

cloned

No

CT456

15605183

hypothetical protein CT456 [Chlamydia tr...

1005

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02736
(show subtarget assignments)

1

cloned

No

GBAA4352

47778283

argD

acetylornithine aminotransferase [Bacill...

386

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

44%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family