Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05541 (show subtarget assignments)	1	cloned	No	CD3437	126701060	cobS	cobalamin synthase [Clostridium difficil...	257	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RH5	23.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90671 (show subtarget assignments)	8	in_pdb 3O6C 3O6D	Yes	Cj1238	15792562	pdxJ	pyridoxal phosphate biosynthetic protein...	257	Predicted Essential	Community Requests	3O6C	100%	Campylobacter jejuni

IDP01921 (show subtarget assignments)	1	expressed	No	CBU_1154	29541726	trpC	indole-3-glycerol phosphate synthase [Co...	257	Conserved; Drug target functions	Phase 3: June 2008	3QJA	37%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02412 (show subtarget assignments)	1	soluble	No	GBAA4760	47530059	etfB	electron transfer flavoprotein, beta sub...	257	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1EFP	38.2%	Bacillus anthracis	Energy metabolism	Electron transport

IDP00203 (show subtarget assignments)	1	in_pdb 3T7B	No	YPO3925	16124056	argB	acetylglutamate kinase	257	Virulence	Phase 1: October 2007	3T7B	100%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01822 (show subtarget assignments)	1	cloned	No	FTT0317	56707470	uppS	undecaprenyl pyrophosphate synthetase [F...	257	Conserved; Drug target functions	Phase 3: June 2008	1JP3	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01753 (show subtarget assignments)	1	expressed	No	CBU_0423	29541032	panC	pantoate--beta-alanine ligase [Coxiella ...	257	Conserved; Drug target functions	Phase 3: June 2008	3N8H	40.9%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP05094 (show subtarget assignments)	1	purified	No	BA_3160	30257733		hypothetical protein BA_3160 [Bacillus a...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP02369 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3204	47778134		short chain dehydrogenase [Bacillus anth...	257	Conserved; Essential;	Phase 3: June 2008	3ICC	61.9%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP04519 (show subtarget assignments)	1	cloned	No	CPF_2988	110798938	soj	sporulation initiation inhibitor protein...	257	conserved gene; putative drug target function;	Phase 4: April 2009	1WCV	43.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05372 (show subtarget assignments)	1	cloned	No	BA_0397	30253932		LPXTG-motif cell wall anchor domain prot...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GHG	24.9%	Bacillus anthracis	Cell envelope: Other

IDP04636 (show subtarget assignments)	1	soluble	No	FTT0238	56707395	aroE1	shikimate 5-dehydrogenase [Francisella t...	257	drug target; conserved gene;	Phase 4: April 2009	3O8Q	36.8%	Francisella tularensis

IDP05163 (show subtarget assignments)	1	cloned	No	BA_1719	30256005		putative flagellar basal-body rod protei...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Chemotaxis and motility

IDP05407 (show subtarget assignments)	1	soluble	No	BA_1485	30255415		conserved domain protein [Bacillus anthr...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP00628 (show subtarget assignments)	1	cloned	No	SACOL0369	57285482		prophage L54a, Clp protease, putative	257	Drug Target Function	Phase 2: March 2008	1Y7O	22.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00608 (show subtarget assignments)	1	expressed	No	SACOL0127	57285334		phosphonate ABC transporter, ATP-binding...	257	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35%	Staphylococcus aureus	Transport and binding proteins	Other

IDP92034 (show subtarget assignments)	8	selected	No	TGME49_024900	237833733		adenylate kinase, putative [Toxoplasma g...	257	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3TLX	55.6%	Toxoplasma gondii

IDP00130 (show subtarget assignments)	1	in_crystallization_trials	No	NT01ST5659	16767805	yjjV	putative deoxyribonuclease YjjV	257	Virulence	Phase 1: October 2007	1ZZM	76.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP01145 (show subtarget assignments)	1	expressed	No	BA_0188	30253695		oligopeptide ABC transporter, ATP-bindin...	257	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	34.6%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02157 (show subtarget assignments)	1	expressed	No	GBAA3961	47778228	uppS	undecaprenyl diphosphate synthase [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1F75	55.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02071 (show subtarget assignments)	1	expressed	No	CBU_1388	29541953	map	methionine aminopeptidase, type I [Coxie...	258	Conserved; Drug target functions	Community Interest	1MAT	65.1%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP04313 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2368	47527663	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	258	virulence factor; putative drug target function;	Phase 4: April 2009	2FWM	45.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00527 (show subtarget assignments)	1	purified	No	YPO0129	16120472	bioH	putative biotin biosynthesis protein	258	Drug Target Function	Phase 2: March 2008	1M33	63.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02005 (show subtarget assignments)	1	cloned	No	GBAA0543	47525816		penicillin-binding domain-containing pro...	258	Drug target homolog; Involved in sporulation;	Phase 3: June 2008	2OQO	36%	Bacillus anthracis	Unknown function	General

IDP90510 (show subtarget assignments)	8	soluble	No	Cj1676	15792980	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	258	Predicted Essential	Community Requests	3TX1	32.9%	Campylobacter jejuni

IDP02727 (show subtarget assignments)	1	crystallized	No	GBAA4249	47778264		3-hydroxybutyrate dehydrogenase [Bacillu...	258	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3V2H	42.6%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP04689 (show subtarget assignments)	1	in_pdb 3PEA	Yes	GBAA4761	47530060		enoyl-CoA hydratase [Bacillus anthracis ...	258	conserved gene; putative drug target function;	Phase 4: April 2009	3PEA	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP00897 (show subtarget assignments)	1	expressed	No	STM0771	16764135		putative ABC-type cobalamin/Fe3+-siderop...	258	Conserved Gene / Pathway	Phase 2: March 2008	2ONK	32.2%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP02332 (show subtarget assignments)	1	purified	No	GBAA1462	47526735		UbiE/COQ5 family methlytransferase [Baci...	258	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UJD	22.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01781 (show subtarget assignments)	1	expressed	No	Cj1616	15792921	chuC	hemin ABC transporter, ATP-binding prote...	258	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	31.4%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01158 (show subtarget assignments)	1	expressed	No	BA_4669	30259165		ABC transporter, ATP-binding protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP04345 (show subtarget assignments)	1	in_pdb 3O6V 3PNS	Yes	VC1034	15641047		uridine phosphorylase [Vibrio cholerae O...	258	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3O6V	100%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP00008 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1445	30255378	cysG	uroporphyrin-III C-methyltransferase	258	Drug Target Homolog	Phase 1: October 2007	1PJQ	43.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01604 (show subtarget assignments)	1	crystallized	No	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	3QF4	25.6%	Coxiella burnetii	Transport and binding proteins	Other

IDP91381 (show subtarget assignments)	8	cloned	No	VV1_1469	27364853		Beta-galactosidase/beta-glucuronidase [V...	258	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91588 (show subtarget assignments)	8	cloned	No	BAA24463	2804527		YfiW [Bacillus subtilis]	258	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Bacillus subtilis

IDP01443 (show subtarget assignments)	1	soluble	No	VC2061	15642061		ParA family protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1WCV	34.1%	Vibrio cholerae	Cellular processes	Cell division

IDP90754 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0498	15791862	trpC	indole-3-glycerol phosphate synthase [Ca...	258	Predicted Essential	Community Requests	3TSM	39%	Campylobacter jejuni

IDP90590 (show subtarget assignments)	8	cloned	No	Cj0770c	15792108		lipoprotein, NLPA family [Campylobacter ...	258	Predicted Essential	Community Requests	1P99	35.7%	Campylobacter jejuni

IDP92085 (show subtarget assignments)	8	selected	No	TGME49_116190	237830977		superoxide dismutase, putative [Toxoplas...	258	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BPI	41.9%	Toxoplasma gondii

IDP92049 (show subtarget assignments)	8	selected	No	TGME49_049590	237835989		proteasome subunit alpha type 5, putativ...	258	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3UNB	57.4%	Toxoplasma gondii

IDP02320 (show subtarget assignments)	1	purified	No	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP91427 (show subtarget assignments)	8	cloned	No	VV1_0535	27363998		hypothetical protein VV1_0535 [Vibrio vu...	258	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP05602 (show subtarget assignments)	1	cloned	No	BA_4347	30258847		putative lipase/acylhydrolase [Bacillus ...	259	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP02767 (show subtarget assignments)	1	cloned	No	GBAA4750	47530050		D-alanyl-D-alanine carboxypeptidase fami...	259	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02663 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2182	16804221		hypothetical protein lmo2182 [Listeria m...	259	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2GHI	30.9%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP02464 (show subtarget assignments)	1	cloned	No	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP01932 (show subtarget assignments)	1	cloned	No	CBU_1099	29541673	lepB-1	signal peptidase I [Coxiella burnetii RS...	259	Conserved; Drug target functions	Phase 3: June 2008	1T7D	33.2%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP04424 (show subtarget assignments)	1	purified	No	GBAA4024	47529317	pyrK	dihydroorotate dehydrogenase electron tr...	259	putative drug target function;	Phase 4: April 2009	1EP3	48.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP91028 (show subtarget assignments)	8	selected	No	y3714	22127588		hypothetical protein y3714 [Yersinia pes...	259	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests			Yersinia pestis

IDP01648 (show subtarget assignments)	1	cloned	No	YPO2944	16123127		putative pili chaperone protein [Yersini...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.8%	Yersinia pestis	Cell envelope	Surface structures

IDP01633 (show subtarget assignments)	1	soluble	No	FTT1569c	56708595	lpxA	UDP-N-acetylglucosamine acyltransferase ...	259	Conserved; Drug target functions	Phase 3: June 2008	1LXA	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01367 (show subtarget assignments)	1	purified	No	VC0224	15640254		lipopolysaccharide biosynthesis glycosyl...	259	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92040 (show subtarget assignments)	8	selected	No	TGME49_039310	237834547		ribose 5-phosphate isomerase, putative [...	259	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F8M	42.5%	Toxoplasma gondii

IDP91870 (show subtarget assignments)	8	selected	No	CAA30578	38663		unnamed protein product [Acinetobacter b...	259	drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation	Community Requests	2BKK	34.4%	Acinetobacter baumannii

IDP02133 (show subtarget assignments)	1	expressed	No	YPO0054	16120407	kdtX	lipopolysaccharide core biosynthesis gly...	260	Drug target motif; Involved in virulence; Drug target functions	Phase 3: June 2008	3E25	11.5%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05108 (show subtarget assignments)	1	in_pdb 4DUN	No	CD1761	126699370		hypothetical protein CD1761 [Clostridium...	260	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	4DUN	100%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP05523 (show subtarget assignments)	1	soluble	No	CD2204	126699821		esterase [Clostridium difficile 630]	260	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2UZ0	33.5%	Clostridium difficile	Fatty acid and phospholipid metabolism: Degradation

IDP01430 (show subtarget assignments)	1	in_crystallization_trials	No	VC1863	15641865		amino acid ABC transporter, periplasmic ...	260	Conserved Gene / Pathway	Phase 2: March 2008	1LAF	39.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02794 (show subtarget assignments)	1	purified	No	FTT0477c	56707619	birA	transcription repressor BirA [Francisell...	260	Conserved; Drug target functions	Phase 3: June 2008	1BIA	25.8%	Francisella tularensis	Protein fate	Protein modification and repair

IDP92026 (show subtarget assignments)	8	selected	No	TGME49_016450	237843315		proteasome subunit alpha type 3, putativ...	260	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3UNB	41.2%	Toxoplasma gondii

IDP04332 (show subtarget assignments)	1	cloned	No	YPO2723	218929795		putative OmpA family protein [Yersinia p...	261	virulence factor; putative drug target function;	Phase 4: April 2009	2ZOV	18%	Yersinia pestis	Cell envelope	Other

IDP91528 (show subtarget assignments)	8	in_crystallization_trials	No	lpg1841	52629179	com1	27 kDa outer membrane protein [Legionell...	261	virulence/pathogenesis / Lpg1841 is most closely related to the major antigen of Coxiella burnetti, and o...	Community Requests	3GYK	25.7%	Legionella pneumophila

IDP01009 (show subtarget assignments)	1	cloned	No	STM2535	16765855	sseB	enhanced serine sensitivity protein	261	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP02771 (show subtarget assignments)	1	in_pdb 3N8H 3QTT	Yes	FTT1390	56708439	panC	pantoate-beta-alanine ligase [Francisell...	261	Conserved; Drug target functions	Phase 3: June 2008	3N8H	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP05519 (show subtarget assignments)	1	cloned	No	CD1704	126699311	thiG	thiazole synthase [Clostridium difficile...	261	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XM3	47.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP01675 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5217	47530523		ABC transporter ATP-binding protein [Bac...	261	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2D2E	57.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01606 (show subtarget assignments)	1	cloned	No	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP00721 (show subtarget assignments)	1	expressed	No	SACOL1613	57286135		ABC transporter, ATP-binding protein	261	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	31.8%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP04698 (show subtarget assignments)	1	cloned	No	YPCD1.46	16082734	yscT	needle complex export protein [Yersinia ...	261	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00147 (show subtarget assignments)	1	expressed	No	VC0780	15640799	vibD	vibriobactin synthase component D	261	Virulence	Phase 1: October 2007			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP91501 (show subtarget assignments)	8	cloned	No	VP1674	28898448		translocation protein in type III secret...	261	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP01200 (show subtarget assignments)	1	cloned	No	BA_1707	30255995		transglycosylase, SLT family	261	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04144 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3337	218930358	map	methionine aminopeptidase [Yersinia pest...	261	drug target; virulence factor; putative drug target function;	Community Interest	1C21	55.2%	Yersinia pestis	Protein fate	Protein modification and repair

IDP05292 (show subtarget assignments)	1	cloned	No	CD1600	126699204	thiK	hydroxyethylthiazole kinase [Clostridium...	262	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3HPD	35.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP02429 (show subtarget assignments)	1	expressed	No	FTT0723c	56707841		Short-chain dehydrogenase/reductase fami...	262	Conserved; Drug target functions	Phase 3: June 2008	4E3Z	35.9%	Francisella tularensis	Energy metabolism	Other

IDP02665 (show subtarget assignments)	1	cloned	No	FTT0469	56707611	ksgA	dimethyladenosine transferase [Francisel...	262	Conserved; Drug target functions	Phase 3: June 2008	3TQS	40.8%	Francisella tularensis	Cellular processesProtein synthesis	Toxin production and resistancetRNA and rRNA base modification

IDP90864 (show subtarget assignments)	8	expressed	No	Cj0405	15791772	aroE	shikimate 5-dehydrogenase [Campylobacter...	262	Predicted Essential	Community Requests	3PHG	38.5%	Campylobacter jejuni

IDP04537 (show subtarget assignments)	8	selected	No	CAC05780	12329049	virF	VirF, member of the AraC family of trans...	262	Shigella effector protein	Community Requests	3GBG	26.3%	Shigella flexneri

IDP01019 (show subtarget assignments)	0	work_stopped	No	STM0228	16763618	lpxA	UDP-N-acetylglucosamine acyltransferase ...	262	Essential Gene	Phase 2: March 2008	1LXA	93.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04366 (show subtarget assignments)	1	purified	No	CPF_1531	110800274		amino acid ABC transporter, amino acid-b...	262	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HV1	36.6%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP01903 (show subtarget assignments)	1	in_crystallization_trials	No	STM0750	16764120	ybgF	hypothetical protein STM0750 [Salmonella...	262	Conserved; Drug target functions	Phase 3: June 2008	2WZ7	25.6%	Salmonella enterica	Unknown function	General

IDP00934 (show subtarget assignments)	0	work_stopped	No	STM0779	16764143	modE	DNA-binding transcriptional dual regulat...	262	Conserved Gene / Pathway	Phase 2: March 2008	1B9M	89.3%	Salmonella enterica	Transport and binding proteins	Anions

IDP02329 (show subtarget assignments)	1	in_pdb 3KQF	Yes	GBAA2551	47527840		enoyl-CoA hydratase [Bacillus anthracis ...	262	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3KQF	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP05632 (show subtarget assignments)	1	cloned	No	CD1898	126699508		putative phage-related cell wall hydrola...	262	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QAY	24.4%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP90691 (show subtarget assignments)	8	soluble	No	VC2643	15642638		acetylglutamate kinase [Vibrio cholerae ...	262	Predicted Essential	Community Requests	3T7B	59.5%	Vibrio cholerae

IDP01449 (show subtarget assignments)	1	purified	No	VC2248	15642246		UDP-N-acetylglucosamine acyltransferase ...	262	Drug Target Function	Phase 2: March 2008	1LXA	68.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01427 (show subtarget assignments)	1	purified	No	VC1684	15641688		peptide ABC transporter, ATP-binding pro...	262	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	33.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90371 (show subtarget assignments)	8	cloned	No	CT_109	3328506		CHLPS hypothetical protein [Chlamydia tr...	262	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90556 (show subtarget assignments)	8	cloned	No	YPO1056	16121356	lpxA	UDP-N-acetylglucosamine acyltransferase	262	Predicted Essential	Community Requests	1LXA	81.7%	Yersinia pestis

IDP01321 (show subtarget assignments)	1	purified	No	VC2082	15642082		zinc ABC transporter, ATP-binding protei...	262	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02532 (show subtarget assignments)	1	cloned	No	GBAA1879	47527172		M23/37 family peptidase [Bacillus anthra...	262	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05676 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0970	16803010	-	enoyl-(acyl carrier protein) reductase [...	262	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2QIO	61.8%	Listeria monocytogenes	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00063 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4952	30259447		aminoglycoside phosphotransferase family...	263	Virulence	Phase 1: October 2007	3I0O	14.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP90748 (show subtarget assignments)	8	in_pdb 3R0S	Yes	Cj0274	15791645	lpxA	UDP-N-acetylglucosamine acyltransferase ...	263	Predicted Essential	Community Requests	3R0S	100%	Campylobacter jejuni

IDP02695 (show subtarget assignments)	1	soluble	No	Cj0698	15792047	flgG	flagellar basal body rod protein FlgG [C...	263	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3A69	23.6%	Campylobacter jejuni	Unknown function	Enzymes of unknown specificity

IDP90397 (show subtarget assignments)	8	in_crystallization_trials	No	CT_583	3329026	gp6D	CHLTR Plasmid Paralog [Chlamydia trachom...	263	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91025 (show subtarget assignments)	8	in_crystallization_trials	No	y3037	22126914	modA	molybdate transporter periplasmic protei...	263	other biological interest / -	Community Requests	3R26	63.9%	Yersinia pestis

IDP04451 (show subtarget assignments)	1	cloned	No	YPO1043	218928211	ampM	methionine aminopeptidase [Yersinia pest...	263	drug target; putative drug target function;	Community Interest	1MAT	84%	Yersinia pestis	Protein fate	Protein modification and repair

IDP05541
(show subtarget assignments)

1

cloned

No

CD3437

126701060

cobS

cobalamin synthase [Clostridium difficil...

257

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RH5

23.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90671
(show subtarget assignments)

8

in_pdb
3O6C
3O6D

Yes

Cj1238

15792562

pdxJ

pyridoxal phosphate biosynthetic protein...

257

Predicted Essential

Community Requests

3O6C

100%

Campylobacter jejuni

IDP01921
(show subtarget assignments)

1

expressed

No

CBU_1154

29541726

trpC

indole-3-glycerol phosphate synthase [Co...

257

Conserved; Drug target functions

Phase 3: June 2008

3QJA

37%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02412
(show subtarget assignments)

1

soluble

No

GBAA4760

47530059

etfB

electron transfer flavoprotein, beta sub...

257

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1EFP

38.2%

Bacillus anthracis

Energy metabolism

Electron transport

IDP00203
(show subtarget assignments)

1

in_pdb
3T7B

No

YPO3925

16124056

argB

acetylglutamate kinase

257

Virulence

Phase 1: October 2007

3T7B

100%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01822
(show subtarget assignments)

1

cloned

No

FTT0317

56707470

uppS

undecaprenyl pyrophosphate synthetase [F...

257

Conserved; Drug target functions

Phase 3: June 2008

1JP3

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01753
(show subtarget assignments)

1

expressed

No

CBU_0423

29541032

panC

pantoate--beta-alanine ligase [Coxiella ...

257

Conserved; Drug target functions

Phase 3: June 2008

3N8H

40.9%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP05094
(show subtarget assignments)

1

purified

No

BA_3160

30257733

hypothetical protein BA_3160 [Bacillus a...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP02369
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3204

47778134

short chain dehydrogenase [Bacillus anth...

257

Conserved; Essential;

Phase 3: June 2008

3ICC

61.9%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP04519
(show subtarget assignments)

1

cloned

No

CPF_2988

110798938

soj

sporulation initiation inhibitor protein...

257

conserved gene; putative drug target function;

Phase 4: April 2009

1WCV

43.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05372
(show subtarget assignments)

1

cloned

No

BA_0397

30253932

LPXTG-motif cell wall anchor domain prot...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GHG

24.9%

Bacillus anthracis

Cell envelope: Other

IDP04636
(show subtarget assignments)

1

soluble

No

FTT0238

56707395

aroE1

shikimate 5-dehydrogenase [Francisella t...

257

drug target; conserved gene;

Phase 4: April 2009

3O8Q

36.8%

Francisella tularensis

IDP05163
(show subtarget assignments)

1

cloned

No

BA_1719

30256005

putative flagellar basal-body rod protei...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Chemotaxis and motility

IDP05407
(show subtarget assignments)

1

soluble

No

BA_1485

30255415

conserved domain protein [Bacillus anthr...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP00628
(show subtarget assignments)

1

cloned

No

SACOL0369

57285482

prophage L54a, Clp protease, putative

257

Drug Target Function

Phase 2: March 2008

1Y7O

22.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00608
(show subtarget assignments)

1

expressed

No

SACOL0127

57285334

phosphonate ABC transporter, ATP-binding...

257

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35%

Staphylococcus aureus

Transport and binding proteins

Other

IDP92034
(show subtarget assignments)

8

selected

No

TGME49_024900

237833733

adenylate kinase, putative [Toxoplasma g...

257

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3TLX

55.6%

Toxoplasma gondii

IDP00130
(show subtarget assignments)

1

in_crystallization_trials

No

NT01ST5659

16767805

yjjV

putative deoxyribonuclease YjjV

257

Virulence

Phase 1: October 2007

1ZZM

76.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP01145
(show subtarget assignments)

1

expressed

No

BA_0188

30253695

oligopeptide ABC transporter, ATP-bindin...

257

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

34.6%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02157
(show subtarget assignments)

1

expressed

No

GBAA3961

47778228

uppS

undecaprenyl diphosphate synthase [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1F75

55.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02071
(show subtarget assignments)

1

expressed

No

CBU_1388

29541953

map

methionine aminopeptidase, type I [Coxie...

258

Conserved; Drug target functions

Community Interest

1MAT

65.1%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP04313
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2368

47527663

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

258

virulence factor; putative drug target function;

Phase 4: April 2009

2FWM

45.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00527
(show subtarget assignments)

1

purified

No

YPO0129

16120472

bioH

putative biotin biosynthesis protein

258

Drug Target Function

Phase 2: March 2008

1M33

63.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02005
(show subtarget assignments)

1

cloned

No

GBAA0543

47525816

penicillin-binding domain-containing pro...

258

Drug target homolog; Involved in sporulation;

Phase 3: June 2008

2OQO

36%

Bacillus anthracis

Unknown function

General

IDP90510
(show subtarget assignments)

8

soluble

No

Cj1676

15792980

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

258

Predicted Essential

Community Requests

3TX1

32.9%

Campylobacter jejuni

IDP02727
(show subtarget assignments)

1

crystallized

No

GBAA4249

47778264

3-hydroxybutyrate dehydrogenase [Bacillu...

258

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3V2H

42.6%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP04689
(show subtarget assignments)

1

in_pdb
3PEA

Yes

GBAA4761

47530060

enoyl-CoA hydratase [Bacillus anthracis ...

258

conserved gene; putative drug target function;

Phase 4: April 2009

3PEA

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP00897
(show subtarget assignments)

1

expressed

No

STM0771

16764135

putative ABC-type cobalamin/Fe3+-siderop...

258

Conserved Gene / Pathway

Phase 2: March 2008

2ONK

32.2%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP02332
(show subtarget assignments)

1

purified

No

GBAA1462

47526735

UbiE/COQ5 family methlytransferase [Baci...

258

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UJD

22.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01781
(show subtarget assignments)

1

expressed

No

Cj1616

15792921

chuC

hemin ABC transporter, ATP-binding prote...

258

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

31.4%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01158
(show subtarget assignments)

1

expressed

No

BA_4669

30259165

ABC transporter, ATP-binding protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP04345
(show subtarget assignments)

1

in_pdb
3O6V
3PNS

Yes

VC1034

15641047

uridine phosphorylase [Vibrio cholerae O...

258

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3O6V

100%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP00008
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1445

30255378

cysG

uroporphyrin-III C-methyltransferase

258

Drug Target Homolog

Phase 1: October 2007

1PJQ

43.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01604
(show subtarget assignments)

1

crystallized

No

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

3QF4

25.6%

Coxiella burnetii

Transport and binding proteins

Other

IDP91381
(show subtarget assignments)

8

cloned

No

VV1_1469

27364853

Beta-galactosidase/beta-glucuronidase [V...

258

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91588
(show subtarget assignments)

8

cloned

No

BAA24463

2804527

YfiW [Bacillus subtilis]

258

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Bacillus subtilis

IDP01443
(show subtarget assignments)

1

soluble

No

VC2061

15642061

ParA family protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1WCV

34.1%

Vibrio cholerae

Cellular processes

Cell division

IDP90754
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0498

15791862

trpC

indole-3-glycerol phosphate synthase [Ca...

258

Predicted Essential

Community Requests

3TSM

39%

Campylobacter jejuni

IDP90590
(show subtarget assignments)

8

cloned

No

Cj0770c

15792108

lipoprotein, NLPA family [Campylobacter ...

258

Predicted Essential

Community Requests

1P99

35.7%

Campylobacter jejuni

IDP92085
(show subtarget assignments)

8

selected

No

TGME49_116190

237830977

superoxide dismutase, putative [Toxoplas...

258

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BPI

41.9%

Toxoplasma gondii

IDP92049
(show subtarget assignments)

8

selected

No

TGME49_049590

237835989

proteasome subunit alpha type 5, putativ...

258

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3UNB

57.4%

Toxoplasma gondii

IDP02320
(show subtarget assignments)

1

purified

No

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP91427
(show subtarget assignments)

8

cloned

No

VV1_0535

27363998

hypothetical protein VV1_0535 [Vibrio vu...

258

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP05602
(show subtarget assignments)

1

cloned

No

BA_4347

30258847

putative lipase/acylhydrolase [Bacillus ...

259

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP02767
(show subtarget assignments)

1

cloned

No

GBAA4750

47530050

D-alanyl-D-alanine carboxypeptidase fami...

259

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02663
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2182

16804221

hypothetical protein lmo2182 [Listeria m...

259

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2GHI

30.9%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP02464
(show subtarget assignments)

1

cloned

No

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP01932
(show subtarget assignments)

1

cloned

No

CBU_1099

29541673

lepB-1

signal peptidase I [Coxiella burnetii RS...

259

Conserved; Drug target functions

Phase 3: June 2008

1T7D

33.2%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP04424
(show subtarget assignments)

1

purified

No

GBAA4024

47529317

pyrK

dihydroorotate dehydrogenase electron tr...

259

putative drug target function;

Phase 4: April 2009

1EP3

48.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP91028
(show subtarget assignments)

8

selected

No

y3714

22127588

hypothetical protein y3714 [Yersinia pes...

259

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

Yersinia pestis

IDP01648
(show subtarget assignments)

1

cloned

No

YPO2944

16123127

putative pili chaperone protein [Yersini...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.8%

Yersinia pestis

Cell envelope

Surface structures

IDP01633
(show subtarget assignments)

1

soluble

No

FTT1569c

56708595

lpxA

UDP-N-acetylglucosamine acyltransferase ...

259

Conserved; Drug target functions

Phase 3: June 2008

1LXA

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01367
(show subtarget assignments)

1

purified

No

VC0224

15640254

lipopolysaccharide biosynthesis glycosyl...

259

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92040
(show subtarget assignments)

8

selected

No

TGME49_039310

237834547

ribose 5-phosphate isomerase, putative [...

259

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F8M

42.5%

Toxoplasma gondii

IDP91870
(show subtarget assignments)

8

selected

No

CAA30578

38663

unnamed protein product [Acinetobacter b...

259

drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation

Community Requests

2BKK

34.4%

Acinetobacter baumannii

IDP02133
(show subtarget assignments)

1

expressed

No

YPO0054

16120407

kdtX

lipopolysaccharide core biosynthesis gly...

260

Drug target motif; Involved in virulence; Drug target functions

Phase 3: June 2008

3E25

11.5%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05108
(show subtarget assignments)

1

in_pdb
4DUN

No

CD1761

126699370

hypothetical protein CD1761 [Clostridium...

260

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

4DUN

100%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP05523
(show subtarget assignments)

1

soluble

No

CD2204

126699821

esterase [Clostridium difficile 630]

260

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2UZ0

33.5%

Clostridium difficile

Fatty acid and phospholipid metabolism: Degradation

IDP01430
(show subtarget assignments)

1

in_crystallization_trials

No

VC1863

15641865

amino acid ABC transporter, periplasmic ...

260

Conserved Gene / Pathway

Phase 2: March 2008

1LAF

39.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02794
(show subtarget assignments)

1

purified

No

FTT0477c

56707619

birA

transcription repressor BirA [Francisell...

260

Conserved; Drug target functions

Phase 3: June 2008

1BIA

25.8%

Francisella tularensis

Protein fate

Protein modification and repair

IDP92026
(show subtarget assignments)

8

selected

No

TGME49_016450

237843315

proteasome subunit alpha type 3, putativ...

260

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3UNB

41.2%

Toxoplasma gondii

IDP04332
(show subtarget assignments)

1

cloned

No

YPO2723

218929795

putative OmpA family protein [Yersinia p...

261

virulence factor; putative drug target function;

Phase 4: April 2009

2ZOV

18%

Yersinia pestis

Cell envelope

Other

IDP91528
(show subtarget assignments)

8

in_crystallization_trials

No

lpg1841

52629179

com1

27 kDa outer membrane protein [Legionell...

261

virulence/pathogenesis / Lpg1841 is most closely related to the major antigen of Coxiella burnetti, and o...

Community Requests

3GYK

25.7%

Legionella pneumophila

IDP01009
(show subtarget assignments)

1

cloned

No

STM2535

16765855

sseB

enhanced serine sensitivity protein

261

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP02771
(show subtarget assignments)

1

in_pdb
3N8H
3QTT

Yes

FTT1390

56708439

panC

pantoate-beta-alanine ligase [Francisell...

261

Conserved; Drug target functions

Phase 3: June 2008

3N8H

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP05519
(show subtarget assignments)

1

cloned

No

CD1704

126699311

thiG

thiazole synthase [Clostridium difficile...

261

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XM3

47.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP01675
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5217

47530523

ABC transporter ATP-binding protein [Bac...

261

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2D2E

57.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01606
(show subtarget assignments)

1

cloned

No

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP00721
(show subtarget assignments)

1

expressed

No

SACOL1613

57286135

ABC transporter, ATP-binding protein

261

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

31.8%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP04698
(show subtarget assignments)

1

cloned

No

YPCD1.46

16082734

yscT

needle complex export protein [Yersinia ...

261

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00147
(show subtarget assignments)

1

expressed

No

VC0780

15640799

vibD

vibriobactin synthase component D

261

Virulence

Phase 1: October 2007

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP91501
(show subtarget assignments)

8

cloned

No

VP1674

28898448

translocation protein in type III secret...

261

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP01200
(show subtarget assignments)

1

cloned

No

BA_1707

30255995

transglycosylase, SLT family

261

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04144
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3337

218930358

map

methionine aminopeptidase [Yersinia pest...

261

drug target; virulence factor; putative drug target function;

Community Interest

1C21

55.2%

Yersinia pestis

Protein fate

Protein modification and repair

IDP05292
(show subtarget assignments)

1

cloned

No

CD1600

126699204

thiK

hydroxyethylthiazole kinase [Clostridium...

262

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3HPD

35.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP02429
(show subtarget assignments)

1

expressed

No

FTT0723c

56707841

Short-chain dehydrogenase/reductase fami...

262

Conserved; Drug target functions

Phase 3: June 2008

4E3Z

35.9%

Francisella tularensis

Energy metabolism

Other

IDP02665
(show subtarget assignments)

1

cloned

No

FTT0469

56707611

ksgA

dimethyladenosine transferase [Francisel...

262

Conserved; Drug target functions

Phase 3: June 2008

3TQS

40.8%

Francisella tularensis

Cellular processesProtein synthesis

Toxin production and resistancetRNA and rRNA base modification

IDP90864
(show subtarget assignments)

8

expressed

No

Cj0405

15791772

aroE

shikimate 5-dehydrogenase [Campylobacter...

262

Predicted Essential

Community Requests

3PHG

38.5%

Campylobacter jejuni

IDP04537
(show subtarget assignments)

8

selected

No

CAC05780

12329049

virF

VirF, member of the AraC family of trans...

262

Shigella effector protein

Community Requests

3GBG

26.3%

Shigella flexneri

IDP01019
(show subtarget assignments)

0

work_stopped

No

STM0228

16763618

lpxA

UDP-N-acetylglucosamine acyltransferase ...

262

Essential Gene

Phase 2: March 2008

1LXA

93.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04366
(show subtarget assignments)

1

purified

No

CPF_1531

110800274

amino acid ABC transporter, amino acid-b...

262

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HV1

36.6%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP01903
(show subtarget assignments)

1

in_crystallization_trials

No

STM0750

16764120

ybgF

hypothetical protein STM0750 [Salmonella...

262

Conserved; Drug target functions

Phase 3: June 2008

2WZ7

25.6%

Salmonella enterica

Unknown function

General

IDP00934
(show subtarget assignments)

0

work_stopped

No

STM0779

16764143

modE

DNA-binding transcriptional dual regulat...

262

Conserved Gene / Pathway

Phase 2: March 2008

1B9M

89.3%

Salmonella enterica

Transport and binding proteins

Anions

IDP02329
(show subtarget assignments)

1

in_pdb
3KQF

Yes

GBAA2551

47527840

enoyl-CoA hydratase [Bacillus anthracis ...

262

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3KQF

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP05632
(show subtarget assignments)

1

cloned

No

CD1898

126699508

putative phage-related cell wall hydrola...

262

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QAY

24.4%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP90691
(show subtarget assignments)

8

soluble

No

VC2643

15642638

acetylglutamate kinase [Vibrio cholerae ...

262

Predicted Essential

Community Requests

3T7B

59.5%

Vibrio cholerae

IDP01449
(show subtarget assignments)

1

purified

No

VC2248

15642246

UDP-N-acetylglucosamine acyltransferase ...

262

Drug Target Function

Phase 2: March 2008

1LXA

68.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01427
(show subtarget assignments)

1

purified

No

VC1684

15641688

peptide ABC transporter, ATP-binding pro...

262

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

33.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90371
(show subtarget assignments)

8

cloned

No

CT_109

3328506

CHLPS hypothetical protein [Chlamydia tr...

262

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90556
(show subtarget assignments)

8

cloned

No

YPO1056

16121356

lpxA

UDP-N-acetylglucosamine acyltransferase

262

Predicted Essential

Community Requests

1LXA

81.7%

Yersinia pestis

IDP01321
(show subtarget assignments)

1

purified

No

VC2082

15642082

zinc ABC transporter, ATP-binding protei...

262

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02532
(show subtarget assignments)

1

cloned

No

GBAA1879

47527172

M23/37 family peptidase [Bacillus anthra...

262

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05676
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0970

16803010

-

enoyl-(acyl carrier protein) reductase [...

262

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2QIO

61.8%

Listeria monocytogenes

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00063
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4952

30259447

aminoglycoside phosphotransferase family...

263

Virulence

Phase 1: October 2007

3I0O

14.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP90748
(show subtarget assignments)

8

in_pdb
3R0S

Yes

Cj0274

15791645

lpxA

UDP-N-acetylglucosamine acyltransferase ...

263

Predicted Essential

Community Requests

3R0S

100%

Campylobacter jejuni

IDP02695
(show subtarget assignments)

1

soluble

No

Cj0698

15792047

flgG

flagellar basal body rod protein FlgG [C...

263

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3A69

23.6%

Campylobacter jejuni

Unknown function

Enzymes of unknown specificity

IDP90397
(show subtarget assignments)

8

in_crystallization_trials

No

CT_583

3329026

gp6D

CHLTR Plasmid Paralog [Chlamydia trachom...

263

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP91025
(show subtarget assignments)

8

in_crystallization_trials

No

y3037

22126914

modA

molybdate transporter periplasmic protei...

263

other biological interest / -

Community Requests

3R26

63.9%

Yersinia pestis

IDP04451
(show subtarget assignments)

1

cloned

No

YPO1043

218928211

ampM

methionine aminopeptidase [Yersinia pest...

263

drug target; putative drug target function;

Community Interest

1MAT

84%

Yersinia pestis

Protein fate

Protein modification and repair