Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00659 (show subtarget assignments)	1	soluble	No	SACOL0806	57285767	pepT	peptidase T	408	Drug Target Function	Phase 2: March 2008	3IFE	55.9%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00648 (show subtarget assignments)	1	cloned	No	SACOL2160	57286373		hemolysin III, putative	227	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04127 (show subtarget assignments)	1	crystallized	No	YPO2889	115348559	pepB	peptidase B [Yersinia pestis CO92]	432	drug target; putative drug target function;	Phase 4: April 2009	1BLL	32.9%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00641 (show subtarget assignments)	1	purified	No	SACOL1866	57284787		serine protease SplD, putative	239	Drug Target Function	Phase 2: March 2008	2VID	43.5%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00628 (show subtarget assignments)	1	cloned	No	SACOL0369	57285482		prophage L54a, Clp protease, putative	257	Drug Target Function	Phase 2: March 2008	1Y7O	22.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01176 (show subtarget assignments)	1	expressed	No	BA_2869	30257466		peptidase, putative	358	Drug Target Function	Phase 2: March 2008	3CE2	22.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01175 (show subtarget assignments)	1	expressed	No	BA_2825	30257427		peptidase M3 family protein	548	Drug Target Function	Phase 2: March 2008	3CE2	22.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01173 (show subtarget assignments)	1	cloned	No	BA_1587	30255887		thermostable carboxypeptidase 1	505	Drug Target Function	Phase 2: March 2008	3HQ2	60.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01172 (show subtarget assignments)	1	purified	No	BA_1206	30255158	pepF-1	oligoendopeptidase F	608	Drug Target Function	Phase 2: March 2008	2QR4	51%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01170 (show subtarget assignments)	1	cloned	No	BA_0165	30253674		prolyl oligopeptidase family protein, pu...	654	Drug Target Function	Phase 2: March 2008	1Z68	11.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02331 (show subtarget assignments)	1	selected	No	GBAA2661	47527952	adP-1	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	30.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02712 (show subtarget assignments)	1	in_pdb 3IFE	No	GBAA3872	47529163	pepT-1	peptidase T [Bacillus anthracis str. 'Am...	410	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IFE	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02314 (show subtarget assignments)	1	cloned	No	GBAA0599	47525877		neutral protease [Bacillus anthracis str...	566	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1NPC	53%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02710 (show subtarget assignments)	1	in_pdb 3LU2	No	lmo2462	16804500		hypothetical protein lmo2462 [Listeria m...	308	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3LU2	100%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01141 (show subtarget assignments)	1	crystallized	No	BA_5155	56404588		Probable cytosol aminopeptidase (Leucine...	494	Drug Target Function	Phase 2: March 2008	3H8E	38.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02298 (show subtarget assignments)	1	soluble	No	GBAA0555	47525828		collagenase,putative [Bacillus anthracis...	965	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4546	33301122		Germination protease precursor (Spore pr...	368	Drug Target Function	Phase 2: March 2008	1C8B	70.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01139 (show subtarget assignments)	1	in_pdb 3Q6D	Yes	BA_4422	30258918	pepQ-1	proline dipeptidase	353	Drug Target Function	Phase 2: March 2008	3Q6D	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01136 (show subtarget assignments)	1	soluble	No	BA_3942	30258453		zinc protease, insulinase family	413	Drug Target Function	Phase 2: March 2008	3HDI	63%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01135 (show subtarget assignments)	1	expressed	No	BA_3911	30258425		renal dipeptidase family protein	307	Drug Target Function	Phase 2: March 2008	3LU2	45.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02283 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0062	16802110		hypothetical protein lmo0062 [Listeria m...	131	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008			Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01134 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2001	30256654		intracellular serine protease	316	Drug Target Function	Phase 2: March 2008	2WV7	52.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01133 (show subtarget assignments)	1	in_pdb 3SKS	Yes	BA_1353	30255290		oligoendopeptidase F, putative	564	Drug Target Function	Phase 2: March 2008	3SKS	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01132 (show subtarget assignments)	1	soluble	No	BA_4703	30259197	loN2	ATP-dependent protease LA	557	Drug Target Function	Phase 2: March 2008	3K1J	26.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02751 (show subtarget assignments)	1	expressed	No	FTT0634	56707759	hflC	SPFH domain-containing protein/band 7 fa...	308	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3BK6	13.6%	Francisella tularensis	Protein fateRegulatory functions	Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP02085 (show subtarget assignments)	1	in_crystallization_trials	No	STM3204	16766504	cca	multifunctional tRNA nucleotidyl transfe...	413	Conserved; Essential; Drug target functions	Phase 3: June 2008	1MIV	29.1%	Salmonella enterica	Transcription	Degradation of RNA

IDP01778 (show subtarget assignments)	1	cloned	No	YPO3689	16123828		putative ribonuclease [Yersinia pestis C...	152	Conserved; CD; Drug target functions	Phase 3: June 2008	1BNE	42.1%	Yersinia pestis	Transcription	Degradation of RNA

IDP00131 (show subtarget assignments)	0	work_stopped	No	NT01ST2113	16765046	rnb	exoribonuclease II	644	Essential	Phase 1: October 2007	2ID0	90.7%	Salmonella enterica	Transcription	Degradation of RNA

IDP01119 (show subtarget assignments)	1	purified	No	BA_0344	30253882	ahpF	alkyl hydroperoxide reductase, F subunit...	508	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	55.7%	Bacillus anthracis	Cellular processes	Detoxification

IDP02562 (show subtarget assignments)	1	purified	No	STM0924	16764286		putative CuZn superoxide dismutase [Salm...	174	Conserved; Drug target functions	Phase 3: June 2008	2WN0	60.3%	Salmonella enterica	Cellular processes	Detoxification

IDP01083 (show subtarget assignments)	1	in_pdb 3OPK	No	STM4324	16767573	cutA	divalent-cation tolerance protein CutA	115	Conserved Gene / Pathway	Phase 2: March 2008	3OPK	100%	Salmonella enterica	Cellular processes	Detoxification

IDP01081 (show subtarget assignments)	1	soluble	No	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	28.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01075 (show subtarget assignments)	1	cloned	No	STM4106	16767372	katG	hydroperoxidase	726	Essential Gene	Phase 2: March 2008	1MWV	64.3%	Salmonella enterica	Cellular processes	Detoxification

IDP04303 (show subtarget assignments)	1	cloned	No	CPF_0251	110800905	lacA	galactoside O-acetyltransferase [Clostri...	204	conserved gene; putative drug target function;	Phase 4: April 2009	1KQA	51%	Clostridium perfringens	Cellular processes	Detoxification

IDP04338 (show subtarget assignments)	1	cloned	No	CPF_1446	110801179	sodF	Mn/Fe superoxide dismutase [Clostridium ...	227	conserved gene; putative drug target function;	Phase 4: April 2009	1JR9	44.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP02110 (show subtarget assignments)	1	expressed	No	STM3820	16767105		putative cytochrome c peroxidase [Salmon...	466	Conserved; Drug target functions	Phase 3: June 2008	1IQC	29.4%	Salmonella enterica	Cellular processes	Detoxification

IDP00545 (show subtarget assignments)	1	cloned	No	YPO2747	16122951	fadJ	multifunctional fatty acid oxidation com...	774	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	34.1%	Yersinia pestis	Cellular processes	Detoxification

IDP00544 (show subtarget assignments)	1	purified	No	YPO2746	16122950	fadI	3-ketoacyl-CoA thiolase	436	Virulence Associated Factor	Phase 2: March 2008	1ULQ	37.4%	Yersinia pestis	Cellular processes	Detoxification

IDP01008 (show subtarget assignments)	1	soluble	No	STM2533	16765853	sseA	3-mercaptopyruvate sulfurtransferase	280	Conserved Gene / Pathway	Phase 2: March 2008	1URH	79.6%	Salmonella enterica	Cellular processes	Detoxification

IDP00970 (show subtarget assignments)	1	soluble	No	STM1682	16765025	tpx	thiol peroxidase	168	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	87.5%	Salmonella enterica	Cellular processes	Detoxification

IDP00503 (show subtarget assignments)	1	purified	No	YPO3766	16123902	fadB	multifunctional fatty acid oxidation com...	729	Virulence Associated Factor	Phase 2: March 2008	1WDK	55.1%	Yersinia pestis	Cellular processes	Detoxification

IDP00943 (show subtarget assignments)	1	crystallized	No	STM0862	16764224	yliJ	putative glutathione S-transferase	208	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	30.8%	Salmonella enterica	Cellular processes	Detoxification

IDP00889 (show subtarget assignments)	1	cloned	No	STM2495	16765815	yfgD	putative arsenate reductase	119	Conserved Gene / Pathway	Phase 2: March 2008	3RDW	61.3%	Salmonella enterica	Cellular processes	Detoxification

IDP01808 (show subtarget assignments)	1	in_pdb 3H1S	Yes	FTT0068	56707247	sodB	superoxide dismutase (Fe) [Francisella t...	192	Drug Target	Phase 3: June 2008	3H1S	100%	Francisella tularensis	Cellular processes	Detoxification

IDP00887 (show subtarget assignments)	1	expressed	No	STM2349	16765676	yfcG	putative glutathione S-transferase	215	Conserved Gene / Pathway	Phase 2: March 2008	3GX0	80.5%	Salmonella enterica	Cellular processes	Detoxification

IDP04016 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0834	110798754	arsC	arsenate reductase ArsC [Clostridium per...	132	conserved gene; putative drug target function;	Phase 4: April 2009	2L17	40.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP01787 (show subtarget assignments)	1	crystallized	No	STM0332	16763712		putative hydrolase/acyltransferase [Salm...	304	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3QYJ	47.4%	Salmonella enterica	Cellular processes	Detoxification

IDP00467 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1974	16122218		N-formimino-L-glutamate deiminase	456	Conserved Gene / Pathway	Phase 2: March 2008	3MDU	59.2%	Yersinia pestis	Cellular processes	Detoxification

IDP01762 (show subtarget assignments)	1	soluble	No	FTT0557	56707687		AhpC/TSA family protein [Francisella tul...	174	Drug Target	Phase 3: June 2008	1NM3	54%	Francisella tularensis	Cellular processes	Detoxification

IDP00841 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0876	57284336		arsenate reductase, putative	118	Conserved Gene / Pathway	Phase 2: March 2008	3FZ4	41.5%	Staphylococcus aureus	Cellular processes	Detoxification

IDP01689 (show subtarget assignments)	1	soluble	No	CBU_1708	29542266	sodB	superoxide dismutase (fe) [Coxiella burn...	193	Conserved; Drug target functions	Phase 3: June 2008	3TQJ	100%	Coxiella burnetii	Cellular processes	Detoxification

IDP01665 (show subtarget assignments)	1	soluble	No	YPO3001	16123182		putative pyridine nucleotide-disulphide ...	548	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	3ICR	58%	Yersinia pestis	Cellular processes	Detoxification

IDP01655 (show subtarget assignments)	1	purified	No	FTT0721c	56707839	katG	peroxidase/catalase [Francisella tularen...	741	Drug Target	Phase 3: June 2008	1MWV	53.3%	Francisella tularensis	Cellular processes	Detoxification

IDP00798 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1368	57284523	kataA	catalase	473	Conserved Gene / Pathway	Phase 2: March 2008	2ISA	63.4%	Staphylococcus aureus	Cellular processes	Detoxification

IDP02677 (show subtarget assignments)	1	cloned	No	FTT0879	56707983	sodC	superoxide dismuate (Cu-Zn) precusor [Fr...	185	Drug Target	Phase 3: June 2008	1EQW	50.3%	Francisella tularensis	Cellular processes	Detoxification

IDP00781 (show subtarget assignments)	1	expressed	No	SACOL0845	57284307	est	carboxylesterase	246	Conserved Gene / Pathway	Phase 2: March 2008	1R1D	57.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00420 (show subtarget assignments)	1	purified	No	YPO1207	16121498	katA	catalase	480	Virulence Associated Factor	Phase 2: March 2008	1M85	84.2%	Yersinia pestis	Cellular processes	Detoxification

IDP01510 (show subtarget assignments)	1	in_crystallization_trials	No	VC0731	15640750		antioxidant, AhpC/Tsa family	207	Conserved Gene / Pathway	Phase 2: March 2008	1ZOF	55.1%	Vibrio cholerae	Cellular processes	Detoxification

IDP01507 (show subtarget assignments)	1	in_crystallization_trials	No	VC2045	15642047		superoxide dismutase, Fe	194	Conserved Gene / Pathway	Phase 2: March 2008	2W7W	86.6%	Vibrio cholerae	Cellular processes	Detoxification

IDP00415 (show subtarget assignments)	1	expressed	No	YPO3767	16123903	fadA	3-ketoacyl-CoA thiolase	387	Virulence Associated Factor	Phase 2: March 2008	3GOA	79.8%	Yersinia pestis	Cellular processes	Detoxification

IDP01476 (show subtarget assignments)	1	soluble	No	VC2694	15642689		superoxide dismutase, Mn	222	Conserved Gene / Pathway	Phase 2: March 2008	2RCV	48.2%	Vibrio cholerae	Cellular processes	Detoxification

IDP04246 (show subtarget assignments)	1	cloned	No	CPF_1362	110799745		aluminum resistance protein [Clostridium...	426	conserved gene; putative drug target function;	Phase 4: April 2009	3GWP	71.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP00724 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1822	57286255	arsR	arsenical resistance operon repressor	104	Conserved Gene / Pathway	Phase 2: March 2008	1R1T	31.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00343 (show subtarget assignments)	1	expressed	No	lmo2235	16804274		hypothetical protein lmo2235	641	Drug Target Function	Phase 2: March 2008	3K30	29.4%	Listeria monocytogenes	Cellular processes	Detoxification

IDP01354 (show subtarget assignments)	1	cloned	No	VC0003	15640035	trmE	tRNA modification GTPase TrmE	464	Conserved Gene / Pathway	Phase 2: March 2008	3GEH	37.9%	Vibrio cholerae	Cellular processes	Detoxification

IDP01325 (show subtarget assignments)	1	in_pdb 3EER 3I07 3LUS	Yes	VCA1006	15601759		organic hydroperoxide resistance protein...	145	Conserved Gene / Pathway	Phase 2: March 2008	3EER	100%	Vibrio cholerae	Cellular processes	Detoxification

IDP01300 (show subtarget assignments)	1	in_pdb 3F0I	Yes	VC2165	15642164		arsenate reductase	116	Conserved Gene / Pathway	Phase 2: March 2008	3F0I	100%	Vibrio cholerae	Cellular processes	Detoxification

IDP00653 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0451	57286824	ahpF	alkyl hydroperoxide reductase, subunit F...	507	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	53.8%	Staphylococcus aureus	Cellular processes	Detoxification

IDP01233 (show subtarget assignments)	1	purified	No	BA_5335	30259811	estA	carboxylesterase	246	Drug Target Function	Phase 2: March 2008	1R1D	79.3%	Bacillus anthracis	Cellular processes	Detoxification

IDP00633 (show subtarget assignments)	1	soluble	No	SACOL0118	57286667	sodA1	superoxide dismutase	199	Conserved Gene / Pathway	Phase 2: March 2008	1JR9	64.5%	Staphylococcus aureus	Cellular processes	Detoxification

IDP02453 (show subtarget assignments)	1	in_pdb 3IGJ 3HJJ	No	GBAA3402	47528687	maA	maltose O-acetyltransferase [Bacillus an...	187	Drug target motif; Conserved; Essential; Drug target functions	Phase 3: June 2008	3HJJ	100%	Bacillus anthracis	Cellular processes	Detoxification

IDP00604 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1610	57286132	sodA2	superoxide dismutase	199	Conserved Gene / Pathway	Phase 2: March 2008	2RCV	71.8%	Staphylococcus aureus	Cellular processes	Detoxification

IDP01148 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1159	30254878	katB	catalase	488	Conserved Gene / Pathway	Phase 2: March 2008	2J2M	64.8%	Bacillus anthracis	Cellular processes	Detoxification

IDP04551 (show subtarget assignments)	1	cloned	No	CPF_2912	110800993	maa	maltose transacetylase [Clostridium perf...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1OCX	64.6%	Clostridium perfringens	Cellular processes	Detoxification

IDP02418 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1279c	15792603		fibronectin domain-containing lipoprotei...	411	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	1QR4	10.9%	Campylobacter jejuni	Transcription	DNA-dependent RNA polymerase

IDP02176 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1002	29541584	birA	birA bifunctional protein [Coxiella burn...	323	Conserved; Drug target functions	Phase 3: June 2008	1BIA	34.1%	Coxiella burnetii	Regulatory functions	DNA interactions

IDP02136 (show subtarget assignments)	1	purified	No	YPO0114	16120460	metJ	transcriptional repressor protein MetJ [...	105	Involved in virulence; Drug target functions	Phase 3: June 2008	1CMA	88.6%	Yersinia pestis	Regulatory functions	DNA interactions

IDP04639 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0556c	56707686	oxyR	oxidative stress transcriptional regulat...	289	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2H98	26.2%	Francisella tularensis	Regulatory functions	DNA interactions

IDP00779 (show subtarget assignments)	1	purified	No	SACOL0691	57285661	sirR	iron-dependent repressor	214	Conserved Gene / Pathway	Phase 2: March 2008	3HRS	37.4%	Staphylococcus aureus	Regulatory functions	DNA interactions

IDP01117 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3754	33301235		LexA repressor	206	Conserved Gene / Pathway	Phase 2: March 2008	3K2Z	38.3%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP04653 (show subtarget assignments)	1	expressed	No	FTT1503	56708541	xerC	integrase/recombinase XerC [Francisella ...	292	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A0P	34.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP00014 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3915	17368674		Protein recA (Recombinase A)	343	Drug Target Homolog	Phase 1: October 2007	1UBC	65.6%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP00109 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF4517	30043269	recF	Rec protein	357	Essential	Phase 1: October 2007	2O5V	27.2%	Shigella flexneri	DNA metabolism	DNA replication, recombination, and repair

IDP02446 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0287	16802333		hypothetical protein lmo0287 [Listeria m...	237	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2OQR	48.1%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP02704 (show subtarget assignments)	1	soluble	No	lmo0007	16802055	gyrA	DNA gyrase subunit A [Listeria monocytog...	842	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2XCO	40.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP01807 (show subtarget assignments)	1	cloned	No	FTT0873c	56707977	radA	DNA repair protein RadA [Francisella tul...	456	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3K1J	15.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP04641 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0693c	56707813	mutM	formamidopyrimidine-DNA glycosylase [Fra...	274	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K82	43.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02606 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0006	16802054	gyrB	DNA gyrase subunit B [Listeria monocytog...	646	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	1EI1	31.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP00446 (show subtarget assignments)	1	purified	No	YPO0892	16121197	xerD	site-specific tyrosine recombinase XerD ...	299	Conserved Gene / Pathway	Phase 2: March 2008	1A0P	80.9%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP00445 (show subtarget assignments)	1	purified	No	YPO3843	16123978	xerC	site-specific tyrosine recombinase XerC ...	303	Conserved Gene / Pathway	Phase 2: March 2008	1A0P	35.6%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP02504 (show subtarget assignments)	1	purified	No	FTT1578c	56708604	ung	uracil-DNA glycosylase [Francisella tula...	220	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1EUG	58.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP00181 (show subtarget assignments)	1	soluble	No	YPO0363	16120698	-	putative membrane transport protein	1119	Similar to Essential SALTY	Phase 1: October 2007	2OAU	5%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP00004 (show subtarget assignments)	1	soluble	No	BA_0001	38257418		Chromosomal replication initiator protei...	446	Drug Target Homolog	Phase 1: October 2007	2Z4R	37.2%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP02481 (show subtarget assignments)	1	cloned	No	Cj1139c	15792464		putative galactosyltransferase [Campylob...	303	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3BCV	24.1%	Campylobacter jejuni	DNA metabolism	DNA replication, recombination, and repair

IDP02479 (show subtarget assignments)	1	cloned	No	lmo1287	16803327	parC	DNA topoisomerase IV subunit A [Listeria...	819	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2INR	41.8%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP00684 (show subtarget assignments)	1	cloned	No	SACOL1926	57286273	mutY	A/G-specific adenine glycosylase	345	Drug Target Function	Phase 2: March 2008	3FSP	45.8%	Staphylococcus aureus	DNA metabolism	DNA replication, recombination, and repair

IDP00676 (show subtarget assignments)	1	expressed	No	SACOL1492	57284593	nth	endonuclease III	219	Drug Target Function	Phase 2: March 2008	1ORN	62.1%	Staphylococcus aureus	DNA metabolism	DNA replication, recombination, and repair

IDP04134 (show subtarget assignments)	1	expressed	No	FTT0666c	56707787		methylpurine-DNA glycosylase family prot...	193	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BNK	39.7%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP01877 (show subtarget assignments)	1	crystallized	No	GBAA0080	47525336		negative regulator of genetic competence...	811	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PXI	80.1%	Bacillus anthracis	Cellular processes	DNA transformation

IDP02820 (show subtarget assignments)	1	purified	No	lmo2196	16804235		hypothetical protein lmo2196 [Listeria m...	558	Known virulence-Intracellular Survival; PMID:11083832	Phase 3: June 2008	1B05	30.1%	Listeria monocytogenes	Cellular processes	DNA transformation

IDP00659
(show subtarget assignments)

1

soluble

No

SACOL0806

57285767

pepT

peptidase T

408

Drug Target Function

Phase 2: March 2008

3IFE

55.9%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00648
(show subtarget assignments)

1

cloned

No

SACOL2160

57286373

hemolysin III, putative

227

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04127
(show subtarget assignments)

1

crystallized

No

YPO2889

115348559

pepB

peptidase B [Yersinia pestis CO92]

432

drug target; putative drug target function;

Phase 4: April 2009

1BLL

32.9%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00641
(show subtarget assignments)

1

purified

No

SACOL1866

57284787

serine protease SplD, putative

239

Drug Target Function

Phase 2: March 2008

2VID

43.5%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00628
(show subtarget assignments)

1

cloned

No

SACOL0369

57285482

prophage L54a, Clp protease, putative

257

Drug Target Function

Phase 2: March 2008

1Y7O

22.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01176
(show subtarget assignments)

1

expressed

No

BA_2869

30257466

peptidase, putative

358

Drug Target Function

Phase 2: March 2008

3CE2

22.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01175
(show subtarget assignments)

1

expressed

No

BA_2825

30257427

peptidase M3 family protein

548

Drug Target Function

Phase 2: March 2008

3CE2

22.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01173
(show subtarget assignments)

1

cloned

No

BA_1587

30255887

thermostable carboxypeptidase 1

505

Drug Target Function

Phase 2: March 2008

3HQ2

60.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01172
(show subtarget assignments)

1

purified

No

BA_1206

30255158

pepF-1

oligoendopeptidase F

608

Drug Target Function

Phase 2: March 2008

2QR4

51%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01170
(show subtarget assignments)

1

cloned

No

BA_0165

30253674

prolyl oligopeptidase family protein, pu...

654

Drug Target Function

Phase 2: March 2008

1Z68

11.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02331
(show subtarget assignments)

1

selected

No

GBAA2661

47527952

adP-1

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

30.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02712
(show subtarget assignments)

1

in_pdb
3IFE

No

GBAA3872

47529163

pepT-1

peptidase T [Bacillus anthracis str. 'Am...

410

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IFE

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02314
(show subtarget assignments)

1

cloned

No

GBAA0599

47525877

neutral protease [Bacillus anthracis str...

566

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1NPC

53%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02710
(show subtarget assignments)

1

in_pdb
3LU2

No

lmo2462

16804500

hypothetical protein lmo2462 [Listeria m...

308

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3LU2

100%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01141
(show subtarget assignments)

1

crystallized

No

BA_5155

56404588

Probable cytosol aminopeptidase (Leucine...

494

Drug Target Function

Phase 2: March 2008

3H8E

38.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02298
(show subtarget assignments)

1

soluble

No

GBAA0555

47525828

collagenase,putative [Bacillus anthracis...

965

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4546

33301122

Germination protease precursor (Spore pr...

368

Drug Target Function

Phase 2: March 2008

1C8B

70.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01139
(show subtarget assignments)

1

in_pdb
3Q6D

Yes

BA_4422

30258918

pepQ-1

proline dipeptidase

353

Drug Target Function

Phase 2: March 2008

3Q6D

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01136
(show subtarget assignments)

1

soluble

No

BA_3942

30258453

zinc protease, insulinase family

413

Drug Target Function

Phase 2: March 2008

3HDI

63%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01135
(show subtarget assignments)

1

expressed

No

BA_3911

30258425

renal dipeptidase family protein

307

Drug Target Function

Phase 2: March 2008

3LU2

45.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02283
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0062

16802110

hypothetical protein lmo0062 [Listeria m...

131

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01134
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2001

30256654

intracellular serine protease

316

Drug Target Function

Phase 2: March 2008

2WV7

52.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01133
(show subtarget assignments)

1

in_pdb
3SKS

Yes

BA_1353

30255290

oligoendopeptidase F, putative

564

Drug Target Function

Phase 2: March 2008

3SKS

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01132
(show subtarget assignments)

1

soluble

No

BA_4703

30259197

loN2

ATP-dependent protease LA

557

Drug Target Function

Phase 2: March 2008

3K1J

26.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02751
(show subtarget assignments)

1

expressed

No

FTT0634

56707759

hflC

SPFH domain-containing protein/band 7 fa...

308

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3BK6

13.6%

Francisella tularensis

Protein fateRegulatory functions

Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP02085
(show subtarget assignments)

1

in_crystallization_trials

No

STM3204

16766504

cca

multifunctional tRNA nucleotidyl transfe...

413

Conserved; Essential; Drug target functions

Phase 3: June 2008

1MIV

29.1%

Salmonella enterica

Transcription

Degradation of RNA

IDP01778
(show subtarget assignments)

1

cloned

No

YPO3689

16123828

putative ribonuclease [Yersinia pestis C...

152

Conserved; CD; Drug target functions

Phase 3: June 2008

1BNE

42.1%

Yersinia pestis

Transcription

Degradation of RNA

IDP00131
(show subtarget assignments)

0

work_stopped

No

NT01ST2113

16765046

rnb

exoribonuclease II

644

Essential

Phase 1: October 2007

2ID0

90.7%

Salmonella enterica

Transcription

Degradation of RNA

IDP01119
(show subtarget assignments)

1

purified

No

BA_0344

30253882

ahpF

alkyl hydroperoxide reductase, F subunit...

508

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

55.7%

Bacillus anthracis

Cellular processes

Detoxification

IDP02562
(show subtarget assignments)

1

purified

No

STM0924

16764286

putative CuZn superoxide dismutase [Salm...

174

Conserved; Drug target functions

Phase 3: June 2008

2WN0

60.3%

Salmonella enterica

Cellular processes

Detoxification

IDP01083
(show subtarget assignments)

1

in_pdb
3OPK

No

STM4324

16767573

cutA

divalent-cation tolerance protein CutA

115

Conserved Gene / Pathway

Phase 2: March 2008

3OPK

100%

Salmonella enterica

Cellular processes

Detoxification

IDP01081
(show subtarget assignments)

1

soluble

No

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

28.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01075
(show subtarget assignments)

1

cloned

No

STM4106

16767372

katG

hydroperoxidase

726

Essential Gene

Phase 2: March 2008

1MWV

64.3%

Salmonella enterica

Cellular processes

Detoxification

IDP04303
(show subtarget assignments)

1

cloned

No

CPF_0251

110800905

lacA

galactoside O-acetyltransferase [Clostri...

204

conserved gene; putative drug target function;

Phase 4: April 2009

1KQA

51%

Clostridium perfringens

Cellular processes

Detoxification

IDP04338
(show subtarget assignments)

1

cloned

No

CPF_1446

110801179

sodF

Mn/Fe superoxide dismutase [Clostridium ...

227

conserved gene; putative drug target function;

Phase 4: April 2009

1JR9

44.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP02110
(show subtarget assignments)

1

expressed

No

STM3820

16767105

putative cytochrome c peroxidase [Salmon...

466

Conserved; Drug target functions

Phase 3: June 2008

1IQC

29.4%

Salmonella enterica

Cellular processes

Detoxification

IDP00545
(show subtarget assignments)

1

cloned

No

YPO2747

16122951

fadJ

multifunctional fatty acid oxidation com...

774

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

34.1%

Yersinia pestis

Cellular processes

Detoxification

IDP00544
(show subtarget assignments)

1

purified

No

YPO2746

16122950

fadI

3-ketoacyl-CoA thiolase

436

Virulence Associated Factor

Phase 2: March 2008

1ULQ

37.4%

Yersinia pestis

Cellular processes

Detoxification

IDP01008
(show subtarget assignments)

1

soluble

No

STM2533

16765853

sseA

3-mercaptopyruvate sulfurtransferase

280

Conserved Gene / Pathway

Phase 2: March 2008

1URH

79.6%

Salmonella enterica

Cellular processes

Detoxification

IDP00970
(show subtarget assignments)

1

soluble

No

STM1682

16765025

tpx

thiol peroxidase

168

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

87.5%

Salmonella enterica

Cellular processes

Detoxification

IDP00503
(show subtarget assignments)

1

purified

No

YPO3766

16123902

fadB

multifunctional fatty acid oxidation com...

729

Virulence Associated Factor

Phase 2: March 2008

1WDK

55.1%

Yersinia pestis

Cellular processes

Detoxification

IDP00943
(show subtarget assignments)

1

crystallized

No

STM0862

16764224

yliJ

putative glutathione S-transferase

208

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

30.8%

Salmonella enterica

Cellular processes

Detoxification

IDP00889
(show subtarget assignments)

1

cloned

No

STM2495

16765815

yfgD

putative arsenate reductase

119

Conserved Gene / Pathway

Phase 2: March 2008

3RDW

61.3%

Salmonella enterica

Cellular processes

Detoxification

IDP01808
(show subtarget assignments)

1

in_pdb
3H1S

Yes

FTT0068

56707247

sodB

superoxide dismutase (Fe) [Francisella t...

192

Drug Target

Phase 3: June 2008

3H1S

100%

Francisella tularensis

Cellular processes

Detoxification

IDP00887
(show subtarget assignments)

1

expressed

No

STM2349

16765676

yfcG

putative glutathione S-transferase

215

Conserved Gene / Pathway

Phase 2: March 2008

3GX0

80.5%

Salmonella enterica

Cellular processes

Detoxification

IDP04016
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0834

110798754

arsC

arsenate reductase ArsC [Clostridium per...

132

conserved gene; putative drug target function;

Phase 4: April 2009

2L17

40.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP01787
(show subtarget assignments)

1

crystallized

No

STM0332

16763712

putative hydrolase/acyltransferase [Salm...

304

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3QYJ

47.4%

Salmonella enterica

Cellular processes

Detoxification

IDP00467
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1974

16122218

N-formimino-L-glutamate deiminase

456

Conserved Gene / Pathway

Phase 2: March 2008

3MDU

59.2%

Yersinia pestis

Cellular processes

Detoxification

IDP01762
(show subtarget assignments)

1

soluble

No

FTT0557

56707687

AhpC/TSA family protein [Francisella tul...

174

Drug Target

Phase 3: June 2008

1NM3

54%

Francisella tularensis

Cellular processes

Detoxification

IDP00841
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0876

57284336

arsenate reductase, putative

118

Conserved Gene / Pathway

Phase 2: March 2008

3FZ4

41.5%

Staphylococcus aureus

Cellular processes

Detoxification

IDP01689
(show subtarget assignments)

1

soluble

No

CBU_1708

29542266

sodB

superoxide dismutase (fe) [Coxiella burn...

193

Conserved; Drug target functions

Phase 3: June 2008

3TQJ

100%

Coxiella burnetii

Cellular processes

Detoxification

IDP01665
(show subtarget assignments)

1

soluble

No

YPO3001

16123182

putative pyridine nucleotide-disulphide ...

548

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

3ICR

58%

Yersinia pestis

Cellular processes

Detoxification

IDP01655
(show subtarget assignments)

1

purified

No

FTT0721c

56707839

katG

peroxidase/catalase [Francisella tularen...

741

Drug Target

Phase 3: June 2008

1MWV

53.3%

Francisella tularensis

Cellular processes

Detoxification

IDP00798
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1368

57284523

kataA

catalase

473

Conserved Gene / Pathway

Phase 2: March 2008

2ISA

63.4%

Staphylococcus aureus

Cellular processes

Detoxification

IDP02677
(show subtarget assignments)

1

cloned

No

FTT0879

56707983

sodC

superoxide dismuate (Cu-Zn) precusor [Fr...

185

Drug Target

Phase 3: June 2008

1EQW

50.3%

Francisella tularensis

Cellular processes

Detoxification

IDP00781
(show subtarget assignments)

1

expressed

No

SACOL0845

57284307

est

carboxylesterase

246

Conserved Gene / Pathway

Phase 2: March 2008

1R1D

57.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00420
(show subtarget assignments)

1

purified

No

YPO1207

16121498

katA

catalase

480

Virulence Associated Factor

Phase 2: March 2008

1M85

84.2%

Yersinia pestis

Cellular processes

Detoxification

IDP01510
(show subtarget assignments)

1

in_crystallization_trials

No

VC0731

15640750

antioxidant, AhpC/Tsa family

207

Conserved Gene / Pathway

Phase 2: March 2008

1ZOF

55.1%

Vibrio cholerae

Cellular processes

Detoxification

IDP01507
(show subtarget assignments)

1

in_crystallization_trials

No

VC2045

15642047

superoxide dismutase, Fe

194

Conserved Gene / Pathway

Phase 2: March 2008

2W7W

86.6%

Vibrio cholerae

Cellular processes

Detoxification

IDP00415
(show subtarget assignments)

1

expressed

No

YPO3767

16123903

fadA

3-ketoacyl-CoA thiolase

387

Virulence Associated Factor

Phase 2: March 2008

3GOA

79.8%

Yersinia pestis

Cellular processes

Detoxification

IDP01476
(show subtarget assignments)

1

soluble

No

VC2694

15642689

superoxide dismutase, Mn

222

Conserved Gene / Pathway

Phase 2: March 2008

2RCV

48.2%

Vibrio cholerae

Cellular processes

Detoxification

IDP04246
(show subtarget assignments)

1

cloned

No

CPF_1362

110799745

aluminum resistance protein [Clostridium...

426

conserved gene; putative drug target function;

Phase 4: April 2009

3GWP

71.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP00724
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1822

57286255

arsR

arsenical resistance operon repressor

104

Conserved Gene / Pathway

Phase 2: March 2008

1R1T

31.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00343
(show subtarget assignments)

1

expressed

No

lmo2235

16804274

hypothetical protein lmo2235

641

Drug Target Function

Phase 2: March 2008

3K30

29.4%

Listeria monocytogenes

Cellular processes

Detoxification

IDP01354
(show subtarget assignments)

1

cloned

No

VC0003

15640035

trmE

tRNA modification GTPase TrmE

464

Conserved Gene / Pathway

Phase 2: March 2008

3GEH

37.9%

Vibrio cholerae

Cellular processes

Detoxification

IDP01325
(show subtarget assignments)

1

in_pdb
3EER
3I07
3LUS

Yes

VCA1006

15601759

organic hydroperoxide resistance protein...

145

Conserved Gene / Pathway

Phase 2: March 2008

3EER

100%

Vibrio cholerae

Cellular processes

Detoxification

IDP01300
(show subtarget assignments)

1

in_pdb
3F0I

Yes

VC2165

15642164

arsenate reductase

116

Conserved Gene / Pathway

Phase 2: March 2008

3F0I

100%

Vibrio cholerae

Cellular processes

Detoxification

IDP00653
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0451

57286824

ahpF

alkyl hydroperoxide reductase, subunit F...

507

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

53.8%

Staphylococcus aureus

Cellular processes

Detoxification

IDP01233
(show subtarget assignments)

1

purified

No

BA_5335

30259811

estA

carboxylesterase

246

Drug Target Function

Phase 2: March 2008

1R1D

79.3%

Bacillus anthracis

Cellular processes

Detoxification

IDP00633
(show subtarget assignments)

1

soluble

No

SACOL0118

57286667

sodA1

superoxide dismutase

199

Conserved Gene / Pathway

Phase 2: March 2008

1JR9

64.5%

Staphylococcus aureus

Cellular processes

Detoxification

IDP02453
(show subtarget assignments)

1

in_pdb
3IGJ
3HJJ

No

GBAA3402

47528687

maA

maltose O-acetyltransferase [Bacillus an...

187

Drug target motif; Conserved; Essential; Drug target functions

Phase 3: June 2008

3HJJ

100%

Bacillus anthracis

Cellular processes

Detoxification

IDP00604
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1610

57286132

sodA2

superoxide dismutase

199

Conserved Gene / Pathway

Phase 2: March 2008

2RCV

71.8%

Staphylococcus aureus

Cellular processes

Detoxification

IDP01148
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1159

30254878

katB

catalase

488

Conserved Gene / Pathway

Phase 2: March 2008

2J2M

64.8%

Bacillus anthracis

Cellular processes

Detoxification

IDP04551
(show subtarget assignments)

1

cloned

No

CPF_2912

110800993

maa

maltose transacetylase [Clostridium perf...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1OCX

64.6%

Clostridium perfringens

Cellular processes

Detoxification

IDP02418
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1279c

15792603

fibronectin domain-containing lipoprotei...

411

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

1QR4

10.9%

Campylobacter jejuni

Transcription

DNA-dependent RNA polymerase

IDP02176
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1002

29541584

birA

birA bifunctional protein [Coxiella burn...

323

Conserved; Drug target functions

Phase 3: June 2008

1BIA

34.1%

Coxiella burnetii

Regulatory functions

DNA interactions

IDP02136
(show subtarget assignments)

1

purified

No

YPO0114

16120460

metJ

transcriptional repressor protein MetJ [...

105

Involved in virulence; Drug target functions

Phase 3: June 2008

1CMA

88.6%

Yersinia pestis

Regulatory functions

DNA interactions

IDP04639
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0556c

56707686

oxyR

oxidative stress transcriptional regulat...

289

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2H98

26.2%

Francisella tularensis

Regulatory functions

DNA interactions

IDP00779
(show subtarget assignments)

1

purified

No

SACOL0691

57285661

sirR

iron-dependent repressor

214

Conserved Gene / Pathway

Phase 2: March 2008

3HRS

37.4%

Staphylococcus aureus

Regulatory functions

DNA interactions

IDP01117
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3754

33301235

LexA repressor

206

Conserved Gene / Pathway

Phase 2: March 2008

3K2Z

38.3%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP04653
(show subtarget assignments)

1

expressed

No

FTT1503

56708541

xerC

integrase/recombinase XerC [Francisella ...

292

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A0P

34.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP00014
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3915

17368674

Protein recA (Recombinase A)

343

Drug Target Homolog

Phase 1: October 2007

1UBC

65.6%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP00109
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF4517

30043269

recF

Rec protein

357

Essential

Phase 1: October 2007

2O5V

27.2%

Shigella flexneri

DNA metabolism

DNA replication, recombination, and repair

IDP02446
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0287

16802333

hypothetical protein lmo0287 [Listeria m...

237

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2OQR

48.1%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP02704
(show subtarget assignments)

1

soluble

No

lmo0007

16802055

gyrA

DNA gyrase subunit A [Listeria monocytog...

842

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2XCO

40.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP01807
(show subtarget assignments)

1

cloned

No

FTT0873c

56707977

radA

DNA repair protein RadA [Francisella tul...

456

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3K1J

15.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP04641
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0693c

56707813

mutM

formamidopyrimidine-DNA glycosylase [Fra...

274

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K82

43.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02606
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0006

16802054

gyrB

DNA gyrase subunit B [Listeria monocytog...

646

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

1EI1

31.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP00446
(show subtarget assignments)

1

purified

No

YPO0892

16121197

xerD

site-specific tyrosine recombinase XerD ...

299

Conserved Gene / Pathway

Phase 2: March 2008

1A0P

80.9%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP00445
(show subtarget assignments)

1

purified

No

YPO3843

16123978

xerC

site-specific tyrosine recombinase XerC ...

303

Conserved Gene / Pathway

Phase 2: March 2008

1A0P

35.6%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP02504
(show subtarget assignments)

1

purified

No

FTT1578c

56708604

ung

uracil-DNA glycosylase [Francisella tula...

220

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1EUG

58.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP00181
(show subtarget assignments)

1

soluble

No

YPO0363

16120698

-

putative membrane transport protein

1119

Similar to Essential SALTY

Phase 1: October 2007

2OAU

5%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP00004
(show subtarget assignments)

1

soluble

No

BA_0001

38257418

Chromosomal replication initiator protei...

446

Drug Target Homolog

Phase 1: October 2007

2Z4R

37.2%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP02481
(show subtarget assignments)

1

cloned

No

Cj1139c

15792464

putative galactosyltransferase [Campylob...

303

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3BCV

24.1%

Campylobacter jejuni

DNA metabolism

DNA replication, recombination, and repair

IDP02479
(show subtarget assignments)

1

cloned

No

lmo1287

16803327

parC

DNA topoisomerase IV subunit A [Listeria...

819

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2INR

41.8%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP00684
(show subtarget assignments)

1

cloned

No

SACOL1926

57286273

mutY

A/G-specific adenine glycosylase

345

Drug Target Function

Phase 2: March 2008

3FSP

45.8%

Staphylococcus aureus

DNA metabolism

DNA replication, recombination, and repair

IDP00676
(show subtarget assignments)

1

expressed

No

SACOL1492

57284593

nth

endonuclease III

219

Drug Target Function

Phase 2: March 2008

1ORN

62.1%

Staphylococcus aureus

DNA metabolism

DNA replication, recombination, and repair

IDP04134
(show subtarget assignments)

1

expressed

No

FTT0666c

56707787

methylpurine-DNA glycosylase family prot...

193

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BNK

39.7%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP01877
(show subtarget assignments)

1

crystallized

No

GBAA0080

47525336

negative regulator of genetic competence...

811

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PXI

80.1%

Bacillus anthracis

Cellular processes

DNA transformation

IDP02820
(show subtarget assignments)

1

purified

No

lmo2196

16804235

hypothetical protein lmo2196 [Listeria m...

558

Known virulence-Intracellular Survival; PMID:11083832

Phase 3: June 2008

1B05

30.1%

Listeria monocytogenes

Cellular processes

DNA transformation

Targets