Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01316 (show subtarget assignments)	1	in_crystallization_trials	No	VC1616	15641624		glutaredoxin, putative	77	Conserved Gene / Pathway	Phase 2: March 2008	2KLX	32.5%	Vibrio cholerae	Energy metabolism	Electron transport

IDP04545 (show subtarget assignments)	1	purified	No	CPF_1198	110801283		glutathione peroxidase [Clostridium perf...	178	drug target; putative drug target function;	Phase 4: April 2009	3CMI	48.3%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP02152 (show subtarget assignments)	1	soluble	No	FTT0955c	56708049	gor	glutathione reductase [Francisella tular...	453	Conserved; Drug target functions	Phase 3: June 2008	1GER	49.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP92095 (show subtarget assignments)	8	selected	No	TGME49_046920	237835543		glutathione reductase, putative [Toxopla...	483	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1GER	46.2%	Toxoplasma gondii

IDP01886 (show subtarget assignments)	1	in_crystallization_trials	No	STM0085	16763475	yabF	glutathione-regulated potassium-efflux s...	176	Conserved; Drug target functions	Phase 3: June 2008	3EYW	87.5%	Salmonella enterica	Energy metabolism	Electron transport

IDP01979 (show subtarget assignments)	1	purified	No	STM3458	16766747	yheR	glutathione-regulated potassium-efflux s...	183	Conserved; Drug target functions	Phase 3: June 2008	3EYW	37.2%	Salmonella enterica	Energy metabolism	Electron transport

IDP02003 (show subtarget assignments)	1	cloned	No	YPO0190	16120529		glutathione-regulated potassium-efflux s...	183	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3EYW	38.3%	Yersinia pestis	Energy metabolism	Electron transport

IDP90703 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1403c	15792721	gapA	glyceraldehyde 3-phosphate dehydrogenase...	332	Predicted Essential	Community Requests	3HJA	50.9%	Campylobacter jejuni

IDP91830 (show subtarget assignments)	8	soluble	No	b1779	1788079	gapA	glyceraldehyde-3-phosphate dehydrogenase...	331	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1S7C	100%	Escherichia coli

IDP04619 (show subtarget assignments)	1	in_pdb 4DIB	No	BAS4478	49187473		glyceraldehyde-3-phosphate dehydrogenase...	342	Proposed to be essential proteins	Phase 4: April 2009	4DIB	100%	Bacillus anthracis

IDP02589 (show subtarget assignments)	0	work_stopped	No	AAW36394	57284300	gapA1	glyceraldehyde 3-phosphate dehydrogenase...	336	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), gapC, catalyzes the oxidative ...	Phase 3: June 2008	3K73	100%	Staphylococcus aureus	N/A	N/A

IDP02277 (show subtarget assignments)	1	crystallized	No	GBAA1434	47526709		glycerate dehydrogenase [Bacillus anthra...	323	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2DBQ	48.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01423 (show subtarget assignments)	1	purified	No	VC1552	15641560	ugpC	glycerol-3-phosphate ABC transporter, AT...	393	Conserved Gene / Pathway	Phase 2: March 2008	2D62	45.5%	Vibrio cholerae	Transport and binding proteins	Other

IDP01422 (show subtarget assignments)	1	expressed	No	VC1549	15641557		glycerol-3-phosphate ABC transporter, pe...	434	Conserved Gene / Pathway	Phase 2: March 2008	2HEU	20%	Vibrio cholerae	Transport and binding proteins	Other

IDP00869 (show subtarget assignments)	1	cloned	No	STM4235	16767485	plsB	glycerol-3-phosphate acyltransferase	806	Essential Gene	Phase 2: March 2008			Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP92554 (show subtarget assignments)	8	selected	No	VV1_1165	27360700		Glycerol-3-phosphate acyltransferase [Vi...	809	potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...	Community Requests			Vibrio vulnificus

IDP01976 (show subtarget assignments)	1	in_pdb 3K96	Yes	CBU_1518	29542077	gpsA	glycerol-3-phosphate dehydrogenase (NAD+...	332	Conserved; Drug target functions	Phase 3: June 2008	3K96	100%	Coxiella burnetii	Energy metabolism	Other

IDP01730 (show subtarget assignments)	1	expressed	No	FTT0871	56707975	gpsA	glycerol-3-phosphate dehydrogenase (NAD(...	332	Conserved; Drug target functions	Phase 3: June 2008	3K96	43.1%	Francisella tularensis	Energy metabolismFatty acid and phospholipid metabolism	AerobicAnaerobic,Biosynthesis

IDP92082 (show subtarget assignments)	8	selected	No	TGME49_107570	237845455		glycerol-3-phosphate dehydrogenase, puta...	401	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1X0V	42.4%	Toxoplasma gondii

IDP92023 (show subtarget assignments)	8	selected	No	TGME49_010260	237845081		glycerol-3-phosphate dehydrogenase, puta...	515	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1YJ8	33.2%	Toxoplasma gondii

IDP00743 (show subtarget assignments)	1	in_pdb 3G25 3GE1	Yes	SACOL1320	57286055	glpK	glycerol kinase	498	Drug Target Function	Phase 2: March 2008	3G25	100%	Staphylococcus aureus	Energy metabolism	Other

IDP01794 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1026	47526305	glpK	glycerol kinase [Bacillus anthracis str....	496	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3G25	75%	Bacillus anthracis	Energy metabolism	Other

IDP01788 (show subtarget assignments)	1	crystallized	No	YPO3827	16123962	glpQ	glycerophosphodiester phosphodiesterase ...	371	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1YDY	71.7%	Yersinia pestis	Central intermediary metabolism	Other

IDP02044 (show subtarget assignments)	1	expressed	No	FTT1132c	56708208	glpQ	glycerophosphoryl diester phosphodiester...	250	Drug Target	Phase 3: June 2008	1O1Z	28%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02381 (show subtarget assignments)	1	expressed	No	GBAA2279	47527580	proV-1	glycine betaine/L-proline ABC transporte...	315	Conserved; Drug target functions	Phase 3: June 2008	1Z47	36.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02339 (show subtarget assignments)	1	expressed	No	YPO2647	16122856	proV	glycine betaine/L-proline transport ATP-...	399	CD; Drug target functions	Phase 3: June 2008	3FVQ	25.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP04614 (show subtarget assignments)	1	purified	No	BAS4131	49187128		glycine cleavage system aminomethyltrans...	366	Proposed to be essential proteins	Phase 4: April 2009	1YX2	66.1%	Bacillus anthracis

IDP01830 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0407	56707556	gcvT	glycine cleavage system aminomethyltrans...	358	Drug Target	Phase 3: June 2008	1VLO	47.9%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02185 (show subtarget assignments)	1	selected	No	FTT0408	56707557	gcvH	glycine cleavage system H protein [Franc...	127	Drug Target	Phase 3: June 2008	3A7A	59.8%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02417 (show subtarget assignments)	1	cloned	No	FTT0812	56707923	gcvH1	glycine cleavage system protein H [Franc...	126	Conserved; Drug target functions	Phase 3: June 2008	1ZKO	40.5%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP01980 (show subtarget assignments)	0	work_stopped	No	STM3054	16766355	gcvH	glycine cleavage system protein H [Salmo...	129	Conserved; Drug target functions	Phase 3: June 2008	3A8I	98.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP04008 (show subtarget assignments)	1	cloned	No	YPO0906	218928079	gcsH	glycine cleavage system protein H [Yersi...	128	conserved gene; putative drug target function;	Phase 4: April 2009	3A7A	75%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04450 (show subtarget assignments)	1	cloned	No	YPO0905	218928078	gcvP	glycine dehydrogenase [Yersinia pestis C...	959	conserved gene; putative drug target function;	Phase 4: April 2009	1WYT	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02575 (show subtarget assignments)	1	cloned	No	GBAA5123	47778366	glgB	glycogen branching enzyme [Bacillus anth...	645	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K1D	43.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00226 (show subtarget assignments)	1	soluble	No	YPO3938	16124066	glgP	glycogen phosphorylase	815	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 1: October 2007	1EM6	49.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01646 (show subtarget assignments)	1	soluble	No	GBAA5119	47530423	glgP	glycogen phosphorylase [Bacillus anthrac...	802	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AXR	46.5%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00553 (show subtarget assignments)	1	expressed	No	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01824 (show subtarget assignments)	1	cloned	No	STM3197	16766497	glgS	glycogen synthesis protein GlgS [Salmone...	69	Conserved; Drug target functions	Phase 3: June 2008	1RRZ	73.9%	Salmonella enterica	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02592 (show subtarget assignments)	1	expressed	No	GBAA1308	47526573		glycolate oxidase, iron-sulfur subunit, ...	442	Conserved; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Energy metabolism	Other

IDP05535 (show subtarget assignments)	1	cloned	No	CD3071	126700688		glycosyl hydrolase [Clostridium difficil...	692	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2XVG	22.3%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP01210 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2805	30257409		glycosyl hydrolase, family 25, putative ...	268	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	61.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01710 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0371	47525642		glycosyl hydrolase family protein [Bacil...	554	Conserved; Drug target functions	Phase 3: June 2008	2ZE0	67%	Bacillus anthracis	Energy metabolism	Sugars

IDP02033 (show subtarget assignments)	1	cloned	No	Cj1135	15792460		glycosyltransferase [Campylobacter jejun...	515	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2Z86	14%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00834 (show subtarget assignments)	1	expressed	No	SACOL2670	57286574		glycosyl transferase, group 1 family pro...	502	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	10.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00788 (show subtarget assignments)	1	crystallized	No	SACOL1043	57284414		glycosyl transferase, group 1 family pro...	493	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	16.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00776 (show subtarget assignments)	1	crystallized	No	SACOL0612	57285627		glycosyl transferase, group 1 family pro...	496	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	11.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00775 (show subtarget assignments)	1	purified	No	SACOL0611	57285626		glycosyl transferase, group 1 family pro...	490	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	14.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00756 (show subtarget assignments)	1	soluble	No	SACOL0115	57286664		glycosyl transferase, group 1 family pro...	388	Conserved Gene / Pathway	Phase 2: March 2008	3C48	21.8%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00753 (show subtarget assignments)	1	cloned	No	SACOL0052	57286607		glycosyl transferase, group 1 family pro...	503	Conserved Gene / Pathway	Phase 2: March 2008	2F9F	9.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01236 (show subtarget assignments)	1	expressed	No	BA_5514	30259974		glycosyl transferase, group 1 family pro...	550	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01216 (show subtarget assignments)	1	expressed	No	BA_3577	30258105		glycosyl transferase, group 1 family pro...	270	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01185 (show subtarget assignments)	1	cloned	No	BA_0280	30253775		glycosyl transferase, group 1 family pro...	443	Drug Target Function	Phase 2: March 2008	2JJM	13.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01972 (show subtarget assignments)	1	cloned	No	CBU_0841	29541435		glycosyl transferase, group 1 family pro...	377	Conserved; Drug target functions	Phase 3: June 2008	2GEJ	24.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02297 (show subtarget assignments)	1	cloned	No	FTT1235c	56708297	lpcC	glycosyl transferase group 1 family prot...	354	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2GEJ	17.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01116 (show subtarget assignments)	1	expressed	No	BA_1693	30255984		glycosyl transferase, group 2 family pro...	150	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01257 (show subtarget assignments)	1	expressed	No	BA_5677	30260125		glycosyl transferase, group 2 family pro...	267	Drug Target Function	Phase 2: March 2008	3BCV	11.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01212 (show subtarget assignments)	1	expressed	No	BA_3024	30257611		glycosyl transferase, group 2 family pro...	490	Essential Gene	Phase 2: March 2008	3E25	9.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01204 (show subtarget assignments)	1	crystallized	No	BA_2274	30256914		glycosyl transferase, group 2 family pro...	406	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01189 (show subtarget assignments)	1	expressed	No	BA_0505	30254033		glycosyl transferase, group 2 family pro...	528	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04625 (show subtarget assignments)	1	cloned	No	BAS5050	49188036		glycosyl transferase, group 4 family pro...	357	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP01203 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2083	30256732		glycosyltransferase, MGT family	402	Conserved Gene / Pathway	Phase 2: March 2008	3IAA	29.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01208 (show subtarget assignments)	1	expressed	No	BA_2638	30257255		glycosyl transferase, putative	387	Essential Gene	Phase 2: March 2008	2IYA	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91282 (show subtarget assignments)	8	cloned	No	NT05BA5499	49182184		glycosyl transferase, WecB/TagA/CpsF fam...	246	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Bacillus anthracis	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92022 (show subtarget assignments)	8	selected	No	TGME49_009160	237840757		glycylpeptide N-tetradecanoyltransferase...	448	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1RXT	48.9%	Toxoplasma gondii

IDP05146 (show subtarget assignments)	1	cloned	No	BAS4784	49187774	-	glycyl-tRNA synthetase [Bacillus anthrac...	458	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	43.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05339 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1622	57651958	glyS	glycyl-tRNA synthetase [Staphylococcus a...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	41.9%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90793 (show subtarget assignments)	8	in_pdb 3UFG 3RF1 3RGL	Yes	Cj0704	15792053	glyQ	glycyl-tRNA synthetase subunit alpha [Ca...	287	Predicted Essential	Community Requests	3RF1	100%	Campylobacter jejuni

IDP05557 (show subtarget assignments)	1	expressed	No	lmo1459	16803499	glyQ	glycyl-tRNA synthetase subunit alpha [Li...	263	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1J5W	54.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90920 (show subtarget assignments)	8	expressed	No	VC0021	15640053	glyQ	glycyl-tRNA synthetase subunit alpha [Vi...	330	Predicted Essential	Community Requests	3RF1	56.4%	Vibrio cholerae

IDP90596 (show subtarget assignments)	8	cloned	No	Cj1234	15792558	glyS	glycyl-tRNA synthetase subunit beta [Cam...	664	Predicted Essential	Community Requests			Campylobacter jejuni

IDP90610 (show subtarget assignments)	8	soluble	No	YPO4071	16124184	glyS	glycyl-tRNA synthetase subunit beta [Yer...	689	Predicted Essential	Community Requests			Yersinia pestis

IDP04181 (show subtarget assignments)	1	crystallized	No	VCA0197	9657589		GMP reductase [Vibrio cholerae O1 biovar...	347	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2A7R	63.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP90275 (show subtarget assignments)	8	soluble	No	TGME49_030450	211965620		GMP synthase, putative [Toxoplasma gondi...	569	Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...	Community Requests	1GPM	51%	Toxoplasma gondii

IDP04497 (show subtarget assignments)	1	soluble	No	VC0768	9655215		GMP synthase [Vibrio cholerae O1 biovar ...	517	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	80.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01688 (show subtarget assignments)	0	work_stopped	No	Cj1313	15792636		GNAT family acetyltransferase [Campyloba...	157	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3EG7	22.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP90283 (show subtarget assignments)	8	cloned	No	TGME49_075440	211969603	GRA6	granule antigen protein GRA6 [Toxoplasma...	224	GRA6 is a secreted dense granule protein that generates protective immunity, e.g...	Community Requests			Toxoplasma gondii

IDP02375 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4701	47530000	engB	GTPase EngB [Bacillus anthracis str. 'Am...	198	Conserved; Essential;	Phase 3: June 2008	1SUL	72.2%	Bacillus anthracis	Unknown function	General

IDP00679 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1699	57284711	obgE	GTPase ObgE	430	Drug Target Function	Phase 2: March 2008	1LNZ	54.2%	Staphylococcus aureus	Unknown function	General

IDP04204 (show subtarget assignments)	1	soluble	No	CPF_2382	110799414	obgE	GTPase ObgE [Clostridium perfringens ATC...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1LNZ	44.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01790 (show subtarget assignments)	1	purified	No	FTT1731c	56708736	obgE	GTPase ObgE [Francisella tularensis subs...	334	Drug Target	Phase 3: June 2008	1UDX	45.5%	Francisella tularensis	Unknown function	General

IDP04532 (show subtarget assignments)	1	cloned	No	STM3301_1_390	16766597	obgE	GTPase ObgE [Salmonella typhimurium LT2]...	390	Salmonella essential protein	Phase 4: April 2009	1LNZ	42.1%	Salmonella enterica

IDP01757 (show subtarget assignments)	1	purified	No	YPO3509	16123655	obgE	GTPase ObgE [Yersinia pestis CO92]	390	Conserved; CD; Drug target functions	Phase 3: June 2008	1LNZ	40.8%	Yersinia pestis	Unknown function	General

IDP02160 (show subtarget assignments)	1	soluble	No	CBU_1245	29541815		GTP-binding protein [Coxiella burnetii R...	443	Conserved; Drug target functions	Phase 3: June 2008	2HJG	38.4%	Coxiella burnetii	Unknown function	General

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP04530 (show subtarget assignments)	1	soluble	No	STM2519_1_490	16765839	engA	GTP-binding protein EngA [Salmonella typ...	490	Salmonella essential protein	Phase 4: April 2009	2HJG	36.1%	Salmonella enterica

IDP00540 (show subtarget assignments)	1	purified	No	YPO2719	16122923	era	GTP-binding protein Era	303	Conserved Gene / Pathway	Phase 2: March 2008	1EGA	83.8%	Yersinia pestis	Cellular processes	Cell division

IDP00678 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1624	57286146	era	GTP-binding protein Era	299	Conserved Gene / Pathway	Phase 2: March 2008	3IEV	45.2%	Staphylococcus aureus	Cellular processes	Cell division

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP02682 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1502	29542061	era	GTP-binding protein Era [Coxiella burnet...	295	Conserved; Drug target functions	Phase 3: June 2008	1EGA	51.2%	Coxiella burnetii	Regulatory functions	RNA interactions

IDP02279 (show subtarget assignments)	1	crystallized	No	FTT1164c	56708234	era	GTP-binding protein Era [Francisella tul...	297	Drug Target	Phase 3: June 2008	1EGA	48.5%	Francisella tularensis	Cellular processesRegulatory functions	Cell divisionRNA interactions

IDP02063 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0387	29540997	cgtA	GTP-binding protein, GTP1/Obg family [Co...	339	Conserved; Drug target functions	Phase 3: June 2008	1UDX	46.3%	Coxiella burnetii	Unknown function	General

IDP02199 (show subtarget assignments)	1	expressed	No	CBU_1505	29542064	lepA	GTP-binding protein LepA [Coxiella burne...	614	Conserved; Drug target functions	Phase 3: June 2008	3CB4	69.9%	Coxiella burnetii	Unknown function	General

IDP00636 (show subtarget assignments)	1	cloned	No	SACOL1118	57285904	typA	GTP-binding protein TypA	615	Drug Target Function	Phase 2: March 2008	3E3X	27.6%	Staphylococcus aureus	Unknown function	General

IDP02675 (show subtarget assignments)	1	expressed	No	CBU_1842	29542398		GTP-binding protein YchF [Coxiella burne...	363	Conserved; Drug target functions	Phase 3: June 2008	1JAL	65.3%	Coxiella burnetii	Unknown function	General

IDP90222 (show subtarget assignments)	1	in_pdb 3H2Y	No	BAS4233	49187229	YqeH	GTP-binding protein YqeH, possibly invol...	368	YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess in...	January 2009	3H2Y	100%	Bacillus anthracis

IDP00990 (show subtarget assignments)	0	work_stopped	No	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01647 (show subtarget assignments)	1	expressed	No	CBU_0795	29541389	folE	GTP cyclohydrolase I [Coxiella burnetii ...	184	Conserved; Drug target functions	Phase 3: June 2008	1WM9	56%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00400 (show subtarget assignments)	0	work_stopped	No	YPO2222	16122451	ribA	GTP cyclohydrolase II	196	Virulence Associated Factor	Phase 2: March 2008	2BZ0	88.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91239 (show subtarget assignments)	8	expressed	No	HP0804	2313934		GTP cyclohydrolase II/3,4-dihydroxy-2-bu...	344	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1TKS	28.2%	Helicobacter pylori	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01316
(show subtarget assignments)

1

in_crystallization_trials

No

VC1616

15641624

glutaredoxin, putative

77

Conserved Gene / Pathway

Phase 2: March 2008

2KLX

32.5%

Vibrio cholerae

Energy metabolism

Electron transport

IDP04545
(show subtarget assignments)

1

purified

No

CPF_1198

110801283

glutathione peroxidase [Clostridium perf...

178

drug target; putative drug target function;

Phase 4: April 2009

3CMI

48.3%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP02152
(show subtarget assignments)

1

soluble

No

FTT0955c

56708049

gor

glutathione reductase [Francisella tular...

453

Conserved; Drug target functions

Phase 3: June 2008

1GER

49.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP92095
(show subtarget assignments)

8

selected

No

TGME49_046920

237835543

glutathione reductase, putative [Toxopla...

483

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1GER

46.2%

Toxoplasma gondii

IDP01886
(show subtarget assignments)

1

in_crystallization_trials

No

STM0085

16763475

yabF

glutathione-regulated potassium-efflux s...

176

Conserved; Drug target functions

Phase 3: June 2008

3EYW

87.5%

Salmonella enterica

Energy metabolism

Electron transport

IDP01979
(show subtarget assignments)

1

purified

No

STM3458

16766747

yheR

glutathione-regulated potassium-efflux s...

183

Conserved; Drug target functions

Phase 3: June 2008

3EYW

37.2%

Salmonella enterica

Energy metabolism

Electron transport

IDP02003
(show subtarget assignments)

1

cloned

No

YPO0190

16120529

glutathione-regulated potassium-efflux s...

183

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3EYW

38.3%

Yersinia pestis

Energy metabolism

Electron transport

IDP90703
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1403c

15792721

gapA

glyceraldehyde 3-phosphate dehydrogenase...

332

Predicted Essential

Community Requests

3HJA

50.9%

Campylobacter jejuni

IDP91830
(show subtarget assignments)

8

soluble

No

b1779

1788079

gapA

glyceraldehyde-3-phosphate dehydrogenase...

331

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1S7C

100%

Escherichia coli

IDP04619
(show subtarget assignments)

1

in_pdb
4DIB

No

BAS4478

49187473

glyceraldehyde-3-phosphate dehydrogenase...

342

Proposed to be essential proteins

Phase 4: April 2009

4DIB

100%

Bacillus anthracis

IDP02589
(show subtarget assignments)

0

work_stopped

No

AAW36394

57284300

gapA1

glyceraldehyde 3-phosphate dehydrogenase...

336

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), gapC, catalyzes the oxidative ...

Phase 3: June 2008

3K73

100%

Staphylococcus aureus

N/A

IDP02277
(show subtarget assignments)

1

crystallized

No

GBAA1434

47526709

glycerate dehydrogenase [Bacillus anthra...

323

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2DBQ

48.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01423
(show subtarget assignments)

1

purified

No

VC1552

15641560

ugpC

glycerol-3-phosphate ABC transporter, AT...

393

Conserved Gene / Pathway

Phase 2: March 2008

2D62

45.5%

Vibrio cholerae

Transport and binding proteins

Other

IDP01422
(show subtarget assignments)

1

expressed

No

VC1549

15641557

glycerol-3-phosphate ABC transporter, pe...

434

Conserved Gene / Pathway

Phase 2: March 2008

2HEU

20%

Vibrio cholerae

Transport and binding proteins

Other

IDP00869
(show subtarget assignments)

1

cloned

No

STM4235

16767485

plsB

glycerol-3-phosphate acyltransferase

806

Essential Gene

Phase 2: March 2008

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP92554
(show subtarget assignments)

8

selected

No

VV1_1165

27360700

Glycerol-3-phosphate acyltransferase [Vi...

809

potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...

Community Requests

Vibrio vulnificus

IDP01976
(show subtarget assignments)

1

in_pdb
3K96

Yes

CBU_1518

29542077

gpsA

glycerol-3-phosphate dehydrogenase (NAD+...

332

Conserved; Drug target functions

Phase 3: June 2008

3K96

100%

Coxiella burnetii

Energy metabolism

Other

IDP01730
(show subtarget assignments)

1

expressed

No

FTT0871

56707975

gpsA

glycerol-3-phosphate dehydrogenase (NAD(...

332

Conserved; Drug target functions

Phase 3: June 2008

3K96

43.1%

Francisella tularensis

Energy metabolismFatty acid and phospholipid metabolism

AerobicAnaerobic,Biosynthesis

IDP92082
(show subtarget assignments)

8

selected

No

TGME49_107570

237845455

glycerol-3-phosphate dehydrogenase, puta...

401

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1X0V

42.4%

Toxoplasma gondii

IDP92023
(show subtarget assignments)

8

selected

No

TGME49_010260

237845081

glycerol-3-phosphate dehydrogenase, puta...

515

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1YJ8

33.2%

Toxoplasma gondii

IDP00743
(show subtarget assignments)

1

in_pdb
3G25
3GE1

Yes

SACOL1320

57286055

glpK

glycerol kinase

498

Drug Target Function

Phase 2: March 2008

3G25

100%

Staphylococcus aureus

Energy metabolism

Other

IDP01794
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1026

47526305

glpK

glycerol kinase [Bacillus anthracis str....

496

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3G25

75%

Bacillus anthracis

Energy metabolism

Other

IDP01788
(show subtarget assignments)

1

crystallized

No

YPO3827

16123962

glpQ

glycerophosphodiester phosphodiesterase ...

371

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1YDY

71.7%

Yersinia pestis

Central intermediary metabolism

Other

IDP02044
(show subtarget assignments)

1

expressed

No

FTT1132c

56708208

glpQ

glycerophosphoryl diester phosphodiester...

250

Drug Target

Phase 3: June 2008

1O1Z

28%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02381
(show subtarget assignments)

1

expressed

No

GBAA2279

47527580

proV-1

glycine betaine/L-proline ABC transporte...

315

Conserved; Drug target functions

Phase 3: June 2008

1Z47

36.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02339
(show subtarget assignments)

1

expressed

No

YPO2647

16122856

proV

glycine betaine/L-proline transport ATP-...

399

CD; Drug target functions

Phase 3: June 2008

3FVQ

25.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP04614
(show subtarget assignments)

1

purified

No

BAS4131

49187128

glycine cleavage system aminomethyltrans...

366

Proposed to be essential proteins

Phase 4: April 2009

1YX2

66.1%

Bacillus anthracis

IDP01830
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0407

56707556

gcvT

glycine cleavage system aminomethyltrans...

358

Drug Target

Phase 3: June 2008

1VLO

47.9%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02185
(show subtarget assignments)

1

selected

No

FTT0408

56707557

gcvH

glycine cleavage system H protein [Franc...

127

Drug Target

Phase 3: June 2008

3A7A

59.8%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02417
(show subtarget assignments)

1

cloned

No

FTT0812

56707923

gcvH1

glycine cleavage system protein H [Franc...

126

Conserved; Drug target functions

Phase 3: June 2008

1ZKO

40.5%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP01980
(show subtarget assignments)

0

work_stopped

No

STM3054

16766355

gcvH

glycine cleavage system protein H [Salmo...

129

Conserved; Drug target functions

Phase 3: June 2008

3A8I

98.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP04008
(show subtarget assignments)

1

cloned

No

YPO0906

218928079

gcsH

glycine cleavage system protein H [Yersi...

128

conserved gene; putative drug target function;

Phase 4: April 2009

3A7A

75%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04450
(show subtarget assignments)

1

cloned

No

YPO0905

218928078

gcvP

glycine dehydrogenase [Yersinia pestis C...

959

conserved gene; putative drug target function;

Phase 4: April 2009

1WYT

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02575
(show subtarget assignments)

1

cloned

No

GBAA5123

47778366

glgB

glycogen branching enzyme [Bacillus anth...

645

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K1D

43.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00226
(show subtarget assignments)

1

soluble

No

YPO3938

16124066

glgP

glycogen phosphorylase

815

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 1: October 2007

1EM6

49.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01646
(show subtarget assignments)

1

soluble

No

GBAA5119

47530423

glgP

glycogen phosphorylase [Bacillus anthrac...

802

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AXR

46.5%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00553
(show subtarget assignments)

1

expressed

No

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01824
(show subtarget assignments)

1

cloned

No

STM3197

16766497

glgS

glycogen synthesis protein GlgS [Salmone...

69

Conserved; Drug target functions

Phase 3: June 2008

1RRZ

73.9%

Salmonella enterica

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02592
(show subtarget assignments)

1

expressed

No

GBAA1308

47526573

glycolate oxidase, iron-sulfur subunit, ...

442

Conserved; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Energy metabolism

Other

IDP05535
(show subtarget assignments)

1

cloned

No

CD3071

126700688

glycosyl hydrolase [Clostridium difficil...

692

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2XVG

22.3%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP01210
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2805

30257409

glycosyl hydrolase, family 25, putative ...

268

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

61.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01710
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0371

47525642

glycosyl hydrolase family protein [Bacil...

554

Conserved; Drug target functions

Phase 3: June 2008

2ZE0

67%

Bacillus anthracis

Energy metabolism

Sugars

IDP02033
(show subtarget assignments)

1

cloned

No

Cj1135

15792460

glycosyltransferase [Campylobacter jejun...

515

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2Z86

14%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00834
(show subtarget assignments)

1

expressed

No

SACOL2670

57286574

glycosyl transferase, group 1 family pro...

502

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

10.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00788
(show subtarget assignments)

1

crystallized

No

SACOL1043

57284414

glycosyl transferase, group 1 family pro...

493

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

16.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00776
(show subtarget assignments)

1

crystallized

No

SACOL0612

57285627

glycosyl transferase, group 1 family pro...

496

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

11.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00775
(show subtarget assignments)

1

purified

No

SACOL0611

57285626

glycosyl transferase, group 1 family pro...

490

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

14.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00756
(show subtarget assignments)

1

soluble

No

SACOL0115

57286664

glycosyl transferase, group 1 family pro...

388

Conserved Gene / Pathway

Phase 2: March 2008

3C48

21.8%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00753
(show subtarget assignments)

1

cloned

No

SACOL0052

57286607

glycosyl transferase, group 1 family pro...

503

Conserved Gene / Pathway

Phase 2: March 2008

2F9F

9.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01236
(show subtarget assignments)

1

expressed

No

BA_5514

30259974

glycosyl transferase, group 1 family pro...

550

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01216
(show subtarget assignments)

1

expressed

No

BA_3577

30258105

glycosyl transferase, group 1 family pro...

270

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01185
(show subtarget assignments)

1

cloned

No

BA_0280

30253775

glycosyl transferase, group 1 family pro...

443

Drug Target Function

Phase 2: March 2008

2JJM

13.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01972
(show subtarget assignments)

1

cloned

No

CBU_0841

29541435

glycosyl transferase, group 1 family pro...

377

Conserved; Drug target functions

Phase 3: June 2008

2GEJ

24.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02297
(show subtarget assignments)

1

cloned

No

FTT1235c

56708297

lpcC

glycosyl transferase group 1 family prot...

354

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2GEJ

17.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01116
(show subtarget assignments)

1

expressed

No

BA_1693

30255984

glycosyl transferase, group 2 family pro...

150

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01257
(show subtarget assignments)

1

expressed

No

BA_5677

30260125

glycosyl transferase, group 2 family pro...

267

Drug Target Function

Phase 2: March 2008

3BCV

11.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01212
(show subtarget assignments)

1

expressed

No

BA_3024

30257611

glycosyl transferase, group 2 family pro...

490

Essential Gene

Phase 2: March 2008

3E25

9.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01204
(show subtarget assignments)

1

crystallized

No

BA_2274

30256914

glycosyl transferase, group 2 family pro...

406

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01189
(show subtarget assignments)

1

expressed

No

BA_0505

30254033

glycosyl transferase, group 2 family pro...

528

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04625
(show subtarget assignments)

1

cloned

No

BAS5050

49188036

glycosyl transferase, group 4 family pro...

357

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP01203
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2083

30256732

glycosyltransferase, MGT family

402

Conserved Gene / Pathway

Phase 2: March 2008

3IAA

29.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01208
(show subtarget assignments)

1

expressed

No

BA_2638

30257255

glycosyl transferase, putative

387

Essential Gene

Phase 2: March 2008

2IYA

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91282
(show subtarget assignments)

8

cloned

No

NT05BA5499

49182184

glycosyl transferase, WecB/TagA/CpsF fam...

246

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Bacillus anthracis

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92022
(show subtarget assignments)

8

selected

No

TGME49_009160

237840757

glycylpeptide N-tetradecanoyltransferase...

448

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1RXT

48.9%

Toxoplasma gondii

IDP05146
(show subtarget assignments)

1

cloned

No

BAS4784

49187774

-

glycyl-tRNA synthetase [Bacillus anthrac...

458

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

43.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05339
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1622

57651958

glyS

glycyl-tRNA synthetase [Staphylococcus a...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

41.9%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90793
(show subtarget assignments)

8

in_pdb
3UFG
3RF1
3RGL

Yes

Cj0704

15792053

glyQ

glycyl-tRNA synthetase subunit alpha [Ca...

287

Predicted Essential

Community Requests

3RF1

100%

Campylobacter jejuni

IDP05557
(show subtarget assignments)

1

expressed

No

lmo1459

16803499

glyQ

glycyl-tRNA synthetase subunit alpha [Li...

263

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1J5W

54.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90920
(show subtarget assignments)

8

expressed

No

VC0021

15640053

glyQ

glycyl-tRNA synthetase subunit alpha [Vi...

330

Predicted Essential

Community Requests

3RF1

56.4%

Vibrio cholerae

IDP90596
(show subtarget assignments)

8

cloned

No

Cj1234

15792558

glyS

glycyl-tRNA synthetase subunit beta [Cam...

664

Predicted Essential

Community Requests

Campylobacter jejuni

IDP90610
(show subtarget assignments)

8

soluble

No

YPO4071

16124184

glyS

glycyl-tRNA synthetase subunit beta [Yer...

689

Predicted Essential

Community Requests

Yersinia pestis

IDP04181
(show subtarget assignments)

1

crystallized

No

VCA0197

9657589

GMP reductase [Vibrio cholerae O1 biovar...

347

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2A7R

63.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP90275
(show subtarget assignments)

8

soluble

No

TGME49_030450

211965620

GMP synthase, putative [Toxoplasma gondi...

569

Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...

Community Requests

1GPM

51%

Toxoplasma gondii

IDP04497
(show subtarget assignments)

1

soluble

No

VC0768

9655215

GMP synthase [Vibrio cholerae O1 biovar ...

517

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

80.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01688
(show subtarget assignments)

0

work_stopped

No

Cj1313

15792636

GNAT family acetyltransferase [Campyloba...

157

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3EG7

22.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP90283
(show subtarget assignments)

8

cloned

No

TGME49_075440

211969603

GRA6

granule antigen protein GRA6 [Toxoplasma...

224

GRA6 is a secreted dense granule protein that generates protective immunity, e.g...

Community Requests

Toxoplasma gondii

IDP02375
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4701

47530000

engB

GTPase EngB [Bacillus anthracis str. 'Am...

198

Conserved; Essential;

Phase 3: June 2008

1SUL

72.2%

Bacillus anthracis

Unknown function

General

IDP00679
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1699

57284711

obgE

GTPase ObgE

430

Drug Target Function

Phase 2: March 2008

1LNZ

54.2%

Staphylococcus aureus

Unknown function

General

IDP04204
(show subtarget assignments)

1

soluble

No

CPF_2382

110799414

obgE

GTPase ObgE [Clostridium perfringens ATC...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1LNZ

44.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01790
(show subtarget assignments)

1

purified

No

FTT1731c

56708736

obgE

GTPase ObgE [Francisella tularensis subs...

334

Drug Target

Phase 3: June 2008

1UDX

45.5%

Francisella tularensis

Unknown function

General

IDP04532
(show subtarget assignments)

1

cloned

No

STM3301_1_390

16766597

obgE

GTPase ObgE [Salmonella typhimurium LT2]...

390

Salmonella essential protein

Phase 4: April 2009

1LNZ

42.1%

Salmonella enterica

IDP01757
(show subtarget assignments)

1

purified

No

YPO3509

16123655

obgE

GTPase ObgE [Yersinia pestis CO92]

390

Conserved; CD; Drug target functions

Phase 3: June 2008

1LNZ

40.8%

Yersinia pestis

Unknown function

General

IDP02160
(show subtarget assignments)

1

soluble

No

CBU_1245

29541815

GTP-binding protein [Coxiella burnetii R...

443

Conserved; Drug target functions

Phase 3: June 2008

2HJG

38.4%

Coxiella burnetii

Unknown function

General

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP04530
(show subtarget assignments)

1

soluble

No

STM2519_1_490

16765839

engA

GTP-binding protein EngA [Salmonella typ...

490

Salmonella essential protein

Phase 4: April 2009

2HJG

36.1%

Salmonella enterica

IDP00540
(show subtarget assignments)

1

purified

No

YPO2719

16122923

era

GTP-binding protein Era

303

Conserved Gene / Pathway

Phase 2: March 2008

1EGA

83.8%

Yersinia pestis

Cellular processes

Cell division

IDP00678
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1624

57286146

era

GTP-binding protein Era

299

Conserved Gene / Pathway

Phase 2: March 2008

3IEV

45.2%

Staphylococcus aureus

Cellular processes

Cell division

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP02682
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1502

29542061

era

GTP-binding protein Era [Coxiella burnet...

295

Conserved; Drug target functions

Phase 3: June 2008

1EGA

51.2%

Coxiella burnetii

Regulatory functions

RNA interactions

IDP02279
(show subtarget assignments)

1

crystallized

No

FTT1164c

56708234

era

GTP-binding protein Era [Francisella tul...

297

Drug Target

Phase 3: June 2008

1EGA

48.5%

Francisella tularensis

Cellular processesRegulatory functions

Cell divisionRNA interactions

IDP02063
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0387

29540997

cgtA

GTP-binding protein, GTP1/Obg family [Co...

339

Conserved; Drug target functions

Phase 3: June 2008

1UDX

46.3%

Coxiella burnetii

Unknown function

General

IDP02199
(show subtarget assignments)

1

expressed

No

CBU_1505

29542064

lepA

GTP-binding protein LepA [Coxiella burne...

614

Conserved; Drug target functions

Phase 3: June 2008

3CB4

69.9%

Coxiella burnetii

Unknown function

General

IDP00636
(show subtarget assignments)

1

cloned

No

SACOL1118

57285904

typA

GTP-binding protein TypA

615

Drug Target Function

Phase 2: March 2008

3E3X

27.6%

Staphylococcus aureus

Unknown function

General

IDP02675
(show subtarget assignments)

1

expressed

No

CBU_1842

29542398

GTP-binding protein YchF [Coxiella burne...

363

Conserved; Drug target functions

Phase 3: June 2008

1JAL

65.3%

Coxiella burnetii

Unknown function

General

IDP90222
(show subtarget assignments)

1

in_pdb
3H2Y

No

BAS4233

49187229

YqeH

GTP-binding protein YqeH, possibly invol...

368

YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess in...

January 2009

3H2Y

100%

Bacillus anthracis

IDP00990
(show subtarget assignments)

0

work_stopped

No

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01647
(show subtarget assignments)

1

expressed

No

CBU_0795

29541389

folE

GTP cyclohydrolase I [Coxiella burnetii ...

184

Conserved; Drug target functions

Phase 3: June 2008

1WM9

56%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00400
(show subtarget assignments)

0

work_stopped

No

YPO2222

16122451

ribA

GTP cyclohydrolase II

196

Virulence Associated Factor

Phase 2: March 2008

2BZ0

88.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91239
(show subtarget assignments)

8

expressed

No

HP0804

2313934

GTP cyclohydrolase II/3,4-dihydroxy-2-bu...

344

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1TKS

28.2%

Helicobacter pylori

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD