Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04147 (show subtarget assignments)	1	expressed	No	YPO3427	115349055	hofC	putative type II secretion system protei...	399	conserved gene; putative drug target function;	Phase 4: April 2009	2VMA	9.8%	Yersinia pestis	Energy metabolism	Electron transport

IDP04724 (show subtarget assignments)	1	cloned	No	YPO1415	115347174	pyrD	dihydroorotate dehydrogenase [Yersinia p...	336	conserved gene; putative drug target function;	Phase 4: April 2009	1F76	83.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04723 (show subtarget assignments)	1	cloned	No	YPO1364	115347123		putative HlyD family secretion protein [...	371	conserved gene; putative drug target function;	Phase 4: April 2009	3FPP	62.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04727 (show subtarget assignments)	1	purified	No	CPF_2072	110800396		hemolysin A [Clostridium perfringens ATC...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3HP7	49.8%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04721 (show subtarget assignments)	1	expressed	No	YPO1289	115347051		conserved hypothetical protein [Yersinia...	380	conserved gene; putative drug target function;	Phase 4: April 2009	2Q18	16.8%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04722 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1357	115347116	ltaA	L-allo-threonine aldolase [Yersinia pest...	339	conserved gene; putative drug target function;	Phase 4: April 2009	1LW4	46.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04733 (show subtarget assignments)	1	cloned	No	CBU_0789	215919045		two component system histidine kinase [C...	831	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.5%	Coxiella burnetii	Signal transduction	Two-component systems

IDP04717 (show subtarget assignments)	1	cloned	No	YPO0832	218928008	agaZ	putative tagatose 6-phosphate kinase [Ye...	432	conserved gene; putative drug target function;	Phase 4: April 2009	2FIQ	51.6%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04719 (show subtarget assignments)	1	expressed	No	YPO1151	218928315	bioB	biotin synthase [Yersinia pestis CO92]	345	conserved gene; putative drug target function;	Phase 4: April 2009	1R30	83.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04714 (show subtarget assignments)	1	expressed	No	YPO0672	218927865	parF	putative acyltransferase [Yersinia pesti...	243	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04735 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1494	115347246	chlN	molybdopterin biosynthesis protein [Yers...	255	conserved gene; putative drug target function;	Phase 4: April 2009	1JW9	67.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP04694 (show subtarget assignments)	1	soluble	No	GBAA5714	47531051	yycG	sensory box histidine kinase YycG [Bacil...	613	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	15.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04700 (show subtarget assignments)	1	cloned	No	YPO0045	218927266	pyrE	orotate phosphoribosyltransferase [Yersi...	215	conserved gene; putative drug target function;	Phase 4: April 2009	1LH0	85.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04671 (show subtarget assignments)	1	soluble	No	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP04689 (show subtarget assignments)	1	in_pdb 3PEA	Yes	GBAA4761	47530060		enoyl-CoA hydratase [Bacillus anthracis ...	258	conserved gene; putative drug target function;	Phase 4: April 2009	3PEA	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04704 (show subtarget assignments)	1	cloned	No	YPO0322	115346138	tyrB	aromatic-amino-acid aminotransferase [Ye...	397	conserved gene; putative drug target function;	Phase 4: April 2009	3TAT	75.6%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04659 (show subtarget assignments)	1	soluble	No	GBAA0272	47525531		sensor histidine kinase [Bacillus anthra...	501	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04668 (show subtarget assignments)	1	cloned	No	GBAA1327	47526592		phaP protein [Bacillus anthracis str. 'A...	174	conserved gene; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04713 (show subtarget assignments)	1	purified	No	YPO0533	218927730	leuA	2-isopropylmalate synthase [Yersinia pes...	520	conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	36.3%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP04656 (show subtarget assignments)	1	cloned	No	FTT1720c	56708726	purL	phosphoribosylformylglycinamidine syntha...	1290	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04645 (show subtarget assignments)	1	soluble	No	FTT0897	56707998	purK	phosphoribosylaminoimidazole carboxylase...	365	conserved gene; putative drug target function;	Phase 4: April 2009	3AW8	42.7%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04243 (show subtarget assignments)	1	soluble	No	CPF_1140	110799522		sensor histidine kinase [Clostridium per...	418	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.7%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04065 (show subtarget assignments)	1	cloned	No	CPF_2985	110800289	yyaC	putative sporulation protein YyaC [Clost...	196	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04400 (show subtarget assignments)	1	cloned	No	YPO2921	218929976	purL	phosphoribosylformylglycinamidine syntha...	1296	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	82.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04633 (show subtarget assignments)	1	in_pdb 4EEI	No	FTT0015	56707195	purB	adenylosuccinate lyase [Francisella tula...	432	conserved gene; putative drug target function;	Phase 4: April 2009	4EEI	100%	Francisella tularensis

IDP04630 (show subtarget assignments)	1	cloned	No	CBU_1228	29654531	qseC	sensor protein qseC [Coxiella burnetii R...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	19%	Coxiella burnetii	Regulatory functions	Other

IDP04569 (show subtarget assignments)	1	cloned	No	CPF_2242	110799545		sensor histidine kinase [Clostridium per...	620	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04560 (show subtarget assignments)	1	in_pdb 3NUA	Yes	CPF_0673	110799762	purC	phosphoribosylaminoimidazole-succinocarb...	235	conserved gene; putative drug target function;	Phase 4: April 2009	3NUA	100%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04551 (show subtarget assignments)	1	cloned	No	CPF_2912	110800993	maa	maltose transacetylase [Clostridium perf...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1OCX	64.6%	Clostridium perfringens	Cellular processes	Detoxification

IDP04552 (show subtarget assignments)	1	cloned	No	CPF_2913	110799629	msrA	methionine sulfoxide reductase A [Clostr...	157	conserved gene; putative drug target function;	Phase 4: April 2009	3BQE	52.2%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04568 (show subtarget assignments)	1	cloned	No	CPF_2087	110800786		stage III sporulation protein AA [Clostr...	294	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04517 (show subtarget assignments)	1	cloned	No	CPF_2840	110799025	ksgA	dimethyladenosine transferase [Clostridi...	285	conserved gene; putative drug target function;	Phase 4: April 2009	3FUT	35.1%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04519 (show subtarget assignments)	1	cloned	No	CPF_2988	110798938	soj	sporulation initiation inhibitor protein...	257	conserved gene; putative drug target function;	Phase 4: April 2009	1WCV	43.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04515 (show subtarget assignments)	1	expressed	No	CPF_2673	110799735		putative sensor histidine kinase [Clostr...	583	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04016 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0834	110798754	arsC	arsenate reductase ArsC [Clostridium per...	132	conserved gene; putative drug target function;	Phase 4: April 2009	2L17	40.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04540 (show subtarget assignments)	1	purified	No	CPF_0511	110801291		sensor histidine kinase [Clostridium per...	516	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	18.2%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP04511 (show subtarget assignments)	1	cloned	No	CPF_2297	110798696		stage II sporulation protein P [Clostrid...	361	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04490 (show subtarget assignments)	1	in_pdb 3MJF	No	YPO3729	218930734	purD	phosphoribosylamine--glycine ligase [Yer...	428	conserved gene; putative drug target function;	Phase 4: April 2009	3MJF	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04485 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3430	115349058		conserved hypothetical protein [Yersinia...	206	conserved gene; putative drug target function;	Phase 4: April 2009	1N3B	62.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04484 (show subtarget assignments)	1	purified	No	YPO3381	115349009	barA	two-component regulatory protein [Yersin...	930	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	7.8%	Yersinia pestis	Regulatory functions	Other

IDP04488 (show subtarget assignments)	1	expressed	No	YPO3685	115349305	yhcQ	putative HlyD family secretion protein [...	311	conserved gene; putative drug target function;	Phase 4: April 2009	2F1M	17%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04473 (show subtarget assignments)	1	expressed	No	YPO2624	115348316	nagD	putative N-acetylglucosamine metabolism ...	250	conserved gene; putative drug target function;	Phase 4: April 2009	2C4N	86%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04483 (show subtarget assignments)	1	expressed	No	YPO3361	115348990	b2747	4-diphosphocytidyl-2C-methyl-D-erythrito...	241	conserved gene; putative drug target function;	Phase 4: April 2009	1VGT	63.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04489 (show subtarget assignments)	1	cloned	No	YPO3728	115349344	purH	bifunctional purine biosynthesis protein...	529	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	44.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04479 (show subtarget assignments)	1	purified	No	YPO3077	115348733	purK	phosphoribosylaminoimidazole carboxylase...	354	conserved gene; putative drug target function;	Phase 4: April 2009	1B6S	76.8%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04481 (show subtarget assignments)	1	cloned	No	YPO3204	115348844	nmpB	phosphate regulon sensor protein PhoR [Y...	438	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Yersinia pestis	Regulatory functions	Other

IDP04019 (show subtarget assignments)	1	cloned	No	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009	3TUF	24.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04204 (show subtarget assignments)	1	soluble	No	CPF_2382	110799414	obgE	GTPase ObgE [Clostridium perfringens ATC...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1LNZ	44.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04304 (show subtarget assignments)	1	cloned	No	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04193 (show subtarget assignments)	1	cloned	No	CPF_2398	110799387	mreB	rod shape-determining protein MreB [Clos...	342	conserved gene; putative drug target function;	Phase 4: April 2009	1JCE	53.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04476 (show subtarget assignments)	1	cloned	No	YPO2773	115348456	ubiX	probable 3-octaprenyl-4-hydroxybenzoate ...	190	conserved gene; putative drug target function;	Phase 4: April 2009	1SBZ	51.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04461 (show subtarget assignments)	1	crystallized	No	YPO1587	218928723	pyrC	dihydroorotase [Yersinia pestis CO92]	348	conserved gene; putative drug target function;	Phase 4: April 2009	3IHN	72.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04463 (show subtarget assignments)	1	cloned	No	YPO1959	115347684	narR	nitrate/nitrite sensor protein [Yersinia...	593	conserved gene; putative drug target function;	Phase 4: April 2009	3EZH	8.4%	Yersinia pestis	Energy metabolism	Anaerobic

IDP04464 (show subtarget assignments)	1	purified	No	YPO1972	218929084	hutI	imidazolonepropionase [Yersinia pestis C...	406	conserved gene; putative drug target function;	Phase 4: April 2009	2OOF	54.9%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04450 (show subtarget assignments)	1	cloned	No	YPO0905	218928078	gcvP	glycine dehydrogenase [Yersinia pestis C...	959	conserved gene; putative drug target function;	Phase 4: April 2009	1WYT	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04446 (show subtarget assignments)	1	cloned	No	YPO0653	115346457	glnE	glutamate-ammonia-ligase adenylyltransfe...	951	conserved gene; putative drug target function;	Phase 4: April 2009	3K7D	38.5%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP04453 (show subtarget assignments)	1	cloned	No	YPO1055	115346834	fabZ	(3R)-hydroxymyristoyl-(acyl carrier prot...	181	conserved gene; putative drug target function;	Phase 4: April 2009	1U1Z	44.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04455 (show subtarget assignments)	1	expressed	No	YPO1336	115347097		putative RNA methyltransferase [Yersinia...	376	conserved gene; putative drug target function;	Phase 4: April 2009	2JJQ	27.7%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP04226 (show subtarget assignments)	1	cloned	No	CPF_0171	110799571	luxS	S-ribosylhomocysteinase [Clostridium per...	151	conserved gene; putative drug target function;	Phase 4: April 2009	1J6W	51%	Clostridium perfringens	Cellular processes	Other

IDP04469 (show subtarget assignments)	1	cloned	No	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04020 (show subtarget assignments)	1	cloned	No	CPF_2112	110800515		cell division protein FtsQ [Clostridium ...	248	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP04423 (show subtarget assignments)	1	in_pdb 3M3H 3OSC	Yes	GBAA4021	47529314	pyrE	orotate phosphoribosyltransferase [Bacil...	210	conserved gene; putative drug target function;	Phase 4: April 2009	3M3H	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04444 (show subtarget assignments)	1	soluble	No	YPO0532	115346340	leuB	3-isopropylmalate dehydrogenase [Yersini...	365	conserved gene; putative drug target function;	Phase 4: April 2009	1CM7	85.5%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP04477 (show subtarget assignments)	1	soluble	No	YPO2829	115348505	purN	putative phosphoribosylglycinamide formy...	212	conserved gene; putative drug target function;	Phase 4: April 2009	2GAR	71.7%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04256 (show subtarget assignments)	1	purified	No	CPF_2006	110801043	spoIVA	stage IV sporulation protein A [Clostrid...	491	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04445 (show subtarget assignments)	1	cloned	No	YPO0619	115346424		putative HlyD family secretion protein [...	349	conserved gene; putative drug target function;	Phase 4: April 2009	4DK1	17.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04471 (show subtarget assignments)	1	purified	No	YPO2370	218929461	pdxH	pyridoxamine 5'-phosphate oxidase [Yersi...	217	conserved gene; putative drug target function;	Phase 4: April 2009	1G76	78.4%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04514 (show subtarget assignments)	1	cloned	No	CPF_2662	110798713		putative spore-cortex-lytic enzyme [Clos...	200	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02742 (show subtarget assignments)	1	expressed	No	GBAA2122	47527416		hypothetical protein GBAA2122 [Bacillus ...	296	Conserved; Involved in sporulation;	Phase 3: June 2008	2R44	42.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02660 (show subtarget assignments)	1	soluble	No	GBAA4615	47778313		hypothetical protein GBAA4615 [Bacillus ...	88	Conserved; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP02795 (show subtarget assignments)	1	in_pdb 3LNO	Yes	GBAA5281	47530589		hypothetical protein GBAA5281 [Bacillus ...	105	Conserved; Involved in sporulation;	Phase 3: June 2008	3LNO	100%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02296 (show subtarget assignments)	1	crystallized	No	GBAA0020	47525275		hypothetical protein GBAA0020 [Bacillus ...	109	Conserved; Involved in sporulation;	Phase 3: June 2008	1YBX	55.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02676 (show subtarget assignments)	1	crystallized	No	GBAA1539	47526813	hisC-1	histidinol-phosphate aminotransferase [B...	370	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3FFH	46.2%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02260 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0072	47777774	folB	dihydroneopterin aldolase [Bacillus anth...	120	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1DHN	43.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02253 (show subtarget assignments)	1	soluble	No	GBAA1968	47527263	hom-1	homoserine dehydrogenase [Bacillus anthr...	431	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3MTJ	37.1%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02226 (show subtarget assignments)	1	crystallized	No	GBAA0164	47525422	yqjI	6-phosphogluconate dehydrogenase [Bacill...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2W8Z	72.3%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP02218 (show subtarget assignments)	1	expressed	No	GBAA2133	47778008	narA-1	molybdenum cofactor biosynthesis protein...	337	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TV7	54.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02213 (show subtarget assignments)	1	expressed	No	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02139 (show subtarget assignments)	1	crystallized	No	GBAA4009	47529302	gmk	guanylate kinase [Bacillus anthracis str...	205	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TAU	63.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02577 (show subtarget assignments)	1	purified	No	GBAA5546	47530866	atpC	F0F1 ATP synthase subunit epsilon [Bacil...	133	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E5Y	69.9%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02132 (show subtarget assignments)	1	cloned	No	GBAA1892	47527187	dra	deoxyribose-phosphate aldolase [Bacillus...	223	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NGJ	57.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02603 (show subtarget assignments)	1	expressed	No	GBAA4274	47529567	nagA	N-acetylglucosamine-6-phosphate deacetyl...	380	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VHL	44%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP02396 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3604	47528890	argH-1	argininosuccinate lyase [Bacillus anthra...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E9F	27.5%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02093 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1970	47527265	thrB	homoserine kinase [Bacillus anthracis st...	297	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HUL	46.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02735 (show subtarget assignments)	1	purified	No	GBAA4334	47529631	ribH	riboflavin synthase subunit beta [Bacill...	153	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VSW	100%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02412 (show subtarget assignments)	1	soluble	No	GBAA4760	47530059	etfB	electron transfer flavoprotein, beta sub...	257	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1EFP	38.2%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02640 (show subtarget assignments)	1	purified	No	GBAA0609	47525887	aspA	aspartate ammonia-lyase [Bacillus anthra...	477	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J3U	70.6%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02367 (show subtarget assignments)	1	soluble	No	GBAA0213	47525471		1-acyl-sn-glycerol-3-phosphate acyltrans...	201	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02798 (show subtarget assignments)	1	purified	No	GBAA5049	47530348		carbonic anhydrase [Bacillus anthracis s...	187	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1G5C	34.8%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02380 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1969	47527264	thrC	threonine synthase [Bacillus anthracis s...	352	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZSJ	58%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02726 (show subtarget assignments)	1	cloned	No	GBAA4229	47529522		maltosaccharide ABC transporter, maltosa...	419	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZYK	41.5%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02377 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1442	47526717	cysC	adenylylsulfate kinase [Bacillus anthrac...	197	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UIE	51.3%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP01917 (show subtarget assignments)	1	soluble	No	GBAA1429	47526701	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	239	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VZW	36.5%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP04147
(show subtarget assignments)

1

expressed

No

YPO3427

115349055

hofC

putative type II secretion system protei...

399

conserved gene; putative drug target function;

Phase 4: April 2009

2VMA

9.8%

Yersinia pestis

Energy metabolism

Electron transport

IDP04724
(show subtarget assignments)

1

cloned

No

YPO1415

115347174

pyrD

dihydroorotate dehydrogenase [Yersinia p...

336

conserved gene; putative drug target function;

Phase 4: April 2009

1F76

83.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04723
(show subtarget assignments)

1

cloned

No

YPO1364

115347123

putative HlyD family secretion protein [...

371

conserved gene; putative drug target function;

Phase 4: April 2009

3FPP

62.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04727
(show subtarget assignments)

1

purified

No

CPF_2072

110800396

hemolysin A [Clostridium perfringens ATC...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3HP7

49.8%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04721
(show subtarget assignments)

1

expressed

No

YPO1289

115347051

conserved hypothetical protein [Yersinia...

380

conserved gene; putative drug target function;

Phase 4: April 2009

2Q18

16.8%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04722
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1357

115347116

ltaA

L-allo-threonine aldolase [Yersinia pest...

339

conserved gene; putative drug target function;

Phase 4: April 2009

1LW4

46.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04733
(show subtarget assignments)

1

cloned

No

CBU_0789

215919045

two component system histidine kinase [C...

831

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.5%

Coxiella burnetii

Signal transduction

Two-component systems

IDP04717
(show subtarget assignments)

1

cloned

No

YPO0832

218928008

agaZ

putative tagatose 6-phosphate kinase [Ye...

432

conserved gene; putative drug target function;

Phase 4: April 2009

2FIQ

51.6%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04719
(show subtarget assignments)

1

expressed

No

YPO1151

218928315

bioB

biotin synthase [Yersinia pestis CO92]

345

conserved gene; putative drug target function;

Phase 4: April 2009

1R30

83.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04714
(show subtarget assignments)

1

expressed

No

YPO0672

218927865

parF

putative acyltransferase [Yersinia pesti...

243

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04735
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1494

115347246

chlN

molybdopterin biosynthesis protein [Yers...

255

conserved gene; putative drug target function;

Phase 4: April 2009

1JW9

67.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP04694
(show subtarget assignments)

1

soluble

No

GBAA5714

47531051

yycG

sensory box histidine kinase YycG [Bacil...

613

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

15.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04700
(show subtarget assignments)

1

cloned

No

YPO0045

218927266

pyrE

orotate phosphoribosyltransferase [Yersi...

215

conserved gene; putative drug target function;

Phase 4: April 2009

1LH0

85.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04671
(show subtarget assignments)

1

soluble

No

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP04689
(show subtarget assignments)

1

in_pdb
3PEA

Yes

GBAA4761

47530060

enoyl-CoA hydratase [Bacillus anthracis ...

258

conserved gene; putative drug target function;

Phase 4: April 2009

3PEA

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04704
(show subtarget assignments)

1

cloned

No

YPO0322

115346138

tyrB

aromatic-amino-acid aminotransferase [Ye...

397

conserved gene; putative drug target function;

Phase 4: April 2009

3TAT

75.6%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04659
(show subtarget assignments)

1

soluble

No

GBAA0272

47525531

sensor histidine kinase [Bacillus anthra...

501

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04668
(show subtarget assignments)

1

cloned

No

GBAA1327

47526592

phaP protein [Bacillus anthracis str. 'A...

174

conserved gene; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04713
(show subtarget assignments)

1

purified

No

YPO0533

218927730

leuA

2-isopropylmalate synthase [Yersinia pes...

520

conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

36.3%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP04656
(show subtarget assignments)

1

cloned

No

FTT1720c

56708726

purL

phosphoribosylformylglycinamidine syntha...

1290

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04645
(show subtarget assignments)

1

soluble

No

FTT0897

56707998

purK

phosphoribosylaminoimidazole carboxylase...

365

conserved gene; putative drug target function;

Phase 4: April 2009

3AW8

42.7%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04243
(show subtarget assignments)

1

soluble

No

CPF_1140

110799522

sensor histidine kinase [Clostridium per...

418

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.7%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04065
(show subtarget assignments)

1

cloned

No

CPF_2985

110800289

yyaC

putative sporulation protein YyaC [Clost...

196

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04400
(show subtarget assignments)

1

cloned

No

YPO2921

218929976

purL

phosphoribosylformylglycinamidine syntha...

1296

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

82.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04633
(show subtarget assignments)

1

in_pdb
4EEI

No

FTT0015

56707195

purB

adenylosuccinate lyase [Francisella tula...

432

conserved gene; putative drug target function;

Phase 4: April 2009

4EEI

100%

Francisella tularensis

IDP04630
(show subtarget assignments)

1

cloned

No

CBU_1228

29654531

qseC

sensor protein qseC [Coxiella burnetii R...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

19%

Coxiella burnetii

Regulatory functions

Other

IDP04569
(show subtarget assignments)

1

cloned

No

CPF_2242

110799545

sensor histidine kinase [Clostridium per...

620

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04560
(show subtarget assignments)

1

in_pdb
3NUA

Yes

CPF_0673

110799762

purC

phosphoribosylaminoimidazole-succinocarb...

235

conserved gene; putative drug target function;

Phase 4: April 2009

3NUA

100%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04551
(show subtarget assignments)

1

cloned

No

CPF_2912

110800993

maa

maltose transacetylase [Clostridium perf...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1OCX

64.6%

Clostridium perfringens

Cellular processes

Detoxification

IDP04552
(show subtarget assignments)

1

cloned

No

CPF_2913

110799629

msrA

methionine sulfoxide reductase A [Clostr...

157

conserved gene; putative drug target function;

Phase 4: April 2009

3BQE

52.2%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04568
(show subtarget assignments)

1

cloned

No

CPF_2087

110800786

stage III sporulation protein AA [Clostr...

294

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04517
(show subtarget assignments)

1

cloned

No

CPF_2840

110799025

ksgA

dimethyladenosine transferase [Clostridi...

285

conserved gene; putative drug target function;

Phase 4: April 2009

3FUT

35.1%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04519
(show subtarget assignments)

1

cloned

No

CPF_2988

110798938

soj

sporulation initiation inhibitor protein...

257

conserved gene; putative drug target function;

Phase 4: April 2009

1WCV

43.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04515
(show subtarget assignments)

1

expressed

No

CPF_2673

110799735

putative sensor histidine kinase [Clostr...

583

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04016
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0834

110798754

arsC

arsenate reductase ArsC [Clostridium per...

132

conserved gene; putative drug target function;

Phase 4: April 2009

2L17

40.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04540
(show subtarget assignments)

1

purified

No

CPF_0511

110801291

sensor histidine kinase [Clostridium per...

516

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

18.2%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP04511
(show subtarget assignments)

1

cloned

No

CPF_2297

110798696

stage II sporulation protein P [Clostrid...

361

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04490
(show subtarget assignments)

1

in_pdb
3MJF

No

YPO3729

218930734

purD

phosphoribosylamine--glycine ligase [Yer...

428

conserved gene; putative drug target function;

Phase 4: April 2009

3MJF

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04485
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3430

115349058

conserved hypothetical protein [Yersinia...

206

conserved gene; putative drug target function;

Phase 4: April 2009

1N3B

62.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04484
(show subtarget assignments)

1

purified

No

YPO3381

115349009

barA

two-component regulatory protein [Yersin...

930

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

7.8%

Yersinia pestis

Regulatory functions

Other

IDP04488
(show subtarget assignments)

1

expressed

No

YPO3685

115349305

yhcQ

putative HlyD family secretion protein [...

311

conserved gene; putative drug target function;

Phase 4: April 2009

2F1M

17%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04473
(show subtarget assignments)

1

expressed

No

YPO2624

115348316

nagD

putative N-acetylglucosamine metabolism ...

250

conserved gene; putative drug target function;

Phase 4: April 2009

2C4N

86%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04483
(show subtarget assignments)

1

expressed

No

YPO3361

115348990

b2747

4-diphosphocytidyl-2C-methyl-D-erythrito...

241

conserved gene; putative drug target function;

Phase 4: April 2009

1VGT

63.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04489
(show subtarget assignments)

1

cloned

No

YPO3728

115349344

purH

bifunctional purine biosynthesis protein...

529

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

44.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04479
(show subtarget assignments)

1

purified

No

YPO3077

115348733

purK

phosphoribosylaminoimidazole carboxylase...

354

conserved gene; putative drug target function;

Phase 4: April 2009

1B6S

76.8%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04481
(show subtarget assignments)

1

cloned

No

YPO3204

115348844

nmpB

phosphate regulon sensor protein PhoR [Y...

438

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Yersinia pestis

Regulatory functions

Other

IDP04019
(show subtarget assignments)

1

cloned

No

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

3TUF

24.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04204
(show subtarget assignments)

1

soluble

No

CPF_2382

110799414

obgE

GTPase ObgE [Clostridium perfringens ATC...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1LNZ

44.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04304
(show subtarget assignments)

1

cloned

No

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04193
(show subtarget assignments)

1

cloned

No

CPF_2398

110799387

mreB

rod shape-determining protein MreB [Clos...

342

conserved gene; putative drug target function;

Phase 4: April 2009

1JCE

53.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04476
(show subtarget assignments)

1

cloned

No

YPO2773

115348456

ubiX

probable 3-octaprenyl-4-hydroxybenzoate ...

190

conserved gene; putative drug target function;

Phase 4: April 2009

1SBZ

51.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04461
(show subtarget assignments)

1

crystallized

No

YPO1587

218928723

pyrC

dihydroorotase [Yersinia pestis CO92]

348

conserved gene; putative drug target function;

Phase 4: April 2009

3IHN

72.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04463
(show subtarget assignments)

1

cloned

No

YPO1959

115347684

narR

nitrate/nitrite sensor protein [Yersinia...

593

conserved gene; putative drug target function;

Phase 4: April 2009

3EZH

8.4%

Yersinia pestis

Energy metabolism

Anaerobic

IDP04464
(show subtarget assignments)

1

purified

No

YPO1972

218929084

hutI

imidazolonepropionase [Yersinia pestis C...

406

conserved gene; putative drug target function;

Phase 4: April 2009

2OOF

54.9%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04450
(show subtarget assignments)

1

cloned

No

YPO0905

218928078

gcvP

glycine dehydrogenase [Yersinia pestis C...

959

conserved gene; putative drug target function;

Phase 4: April 2009

1WYT

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04446
(show subtarget assignments)

1

cloned

No

YPO0653

115346457

glnE

glutamate-ammonia-ligase adenylyltransfe...

951

conserved gene; putative drug target function;

Phase 4: April 2009

3K7D

38.5%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP04453
(show subtarget assignments)

1

cloned

No

YPO1055

115346834

fabZ

(3R)-hydroxymyristoyl-(acyl carrier prot...

181

conserved gene; putative drug target function;

Phase 4: April 2009

1U1Z

44.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04455
(show subtarget assignments)

1

expressed

No

YPO1336

115347097

putative RNA methyltransferase [Yersinia...

376

conserved gene; putative drug target function;

Phase 4: April 2009

2JJQ

27.7%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP04226
(show subtarget assignments)

1

cloned

No

CPF_0171

110799571

luxS

S-ribosylhomocysteinase [Clostridium per...

151

conserved gene; putative drug target function;

Phase 4: April 2009

1J6W

51%

Clostridium perfringens

Cellular processes

Other

IDP04469
(show subtarget assignments)

1

cloned

No

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04020
(show subtarget assignments)

1

cloned

No

CPF_2112

110800515

cell division protein FtsQ [Clostridium ...

248

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP04423
(show subtarget assignments)

1

in_pdb
3M3H
3OSC

Yes

GBAA4021

47529314

pyrE

orotate phosphoribosyltransferase [Bacil...

210

conserved gene; putative drug target function;

Phase 4: April 2009

3M3H

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04444
(show subtarget assignments)

1

soluble

No

YPO0532

115346340

leuB

3-isopropylmalate dehydrogenase [Yersini...

365

conserved gene; putative drug target function;

Phase 4: April 2009

1CM7

85.5%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP04477
(show subtarget assignments)

1

soluble

No

YPO2829

115348505

purN

putative phosphoribosylglycinamide formy...

212

conserved gene; putative drug target function;

Phase 4: April 2009

2GAR

71.7%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04256
(show subtarget assignments)

1

purified

No

CPF_2006

110801043

spoIVA

stage IV sporulation protein A [Clostrid...

491

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04445
(show subtarget assignments)

1

cloned

No

YPO0619

115346424

putative HlyD family secretion protein [...

349

conserved gene; putative drug target function;

Phase 4: April 2009

4DK1

17.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04471
(show subtarget assignments)

1

purified

No

YPO2370

218929461

pdxH

pyridoxamine 5'-phosphate oxidase [Yersi...

217

conserved gene; putative drug target function;

Phase 4: April 2009

1G76

78.4%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP04514
(show subtarget assignments)

1

cloned

No

CPF_2662

110798713

putative spore-cortex-lytic enzyme [Clos...

200

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02742
(show subtarget assignments)

1

expressed

No

GBAA2122

47527416

hypothetical protein GBAA2122 [Bacillus ...

296

Conserved; Involved in sporulation;

Phase 3: June 2008

2R44

42.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02660
(show subtarget assignments)

1

soluble

No

GBAA4615

47778313

hypothetical protein GBAA4615 [Bacillus ...

88

Conserved; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02795
(show subtarget assignments)

1

in_pdb
3LNO

Yes

GBAA5281

47530589

hypothetical protein GBAA5281 [Bacillus ...

105

Conserved; Involved in sporulation;

Phase 3: June 2008

3LNO

100%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02296
(show subtarget assignments)

1

crystallized

No

GBAA0020

47525275

hypothetical protein GBAA0020 [Bacillus ...

109

Conserved; Involved in sporulation;

Phase 3: June 2008

1YBX

55.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02676
(show subtarget assignments)

1

crystallized

No

GBAA1539

47526813

hisC-1

histidinol-phosphate aminotransferase [B...

370

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3FFH

46.2%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02260
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0072

47777774

folB

dihydroneopterin aldolase [Bacillus anth...

120

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1DHN

43.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02253
(show subtarget assignments)

1

soluble

No

GBAA1968

47527263

hom-1

homoserine dehydrogenase [Bacillus anthr...

431

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3MTJ

37.1%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02226
(show subtarget assignments)

1

crystallized

No

GBAA0164

47525422

yqjI

6-phosphogluconate dehydrogenase [Bacill...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2W8Z

72.3%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP02218
(show subtarget assignments)

1

expressed

No

GBAA2133

47778008

narA-1

molybdenum cofactor biosynthesis protein...

337

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TV7

54.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02213
(show subtarget assignments)

1

expressed

No

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02139
(show subtarget assignments)

1

crystallized

No

GBAA4009

47529302

gmk

guanylate kinase [Bacillus anthracis str...

205

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TAU

63.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02577
(show subtarget assignments)

1

purified

No

GBAA5546

47530866

atpC

F0F1 ATP synthase subunit epsilon [Bacil...

133

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E5Y

69.9%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02132
(show subtarget assignments)

1

cloned

No

GBAA1892

47527187

dra

deoxyribose-phosphate aldolase [Bacillus...

223

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NGJ

57.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02603
(show subtarget assignments)

1

expressed

No

GBAA4274

47529567

nagA

N-acetylglucosamine-6-phosphate deacetyl...

380

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VHL

44%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP02396
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3604

47528890

argH-1

argininosuccinate lyase [Bacillus anthra...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E9F

27.5%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02093
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1970

47527265

thrB

homoserine kinase [Bacillus anthracis st...

297

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HUL

46.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02735
(show subtarget assignments)

1

purified

No

GBAA4334

47529631

ribH

riboflavin synthase subunit beta [Bacill...

153

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VSW

100%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02412
(show subtarget assignments)

1

soluble

No

GBAA4760

47530059

etfB

electron transfer flavoprotein, beta sub...

257

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1EFP

38.2%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02640
(show subtarget assignments)

1

purified

No

GBAA0609

47525887

aspA

aspartate ammonia-lyase [Bacillus anthra...

477

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J3U

70.6%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02367
(show subtarget assignments)

1

soluble

No

GBAA0213

47525471

1-acyl-sn-glycerol-3-phosphate acyltrans...

201

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02798
(show subtarget assignments)

1

purified

No

GBAA5049

47530348

carbonic anhydrase [Bacillus anthracis s...

187

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1G5C

34.8%

Bacillus anthracis

Central intermediary metabolism

Other

IDP02380
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1969

47527264

thrC

threonine synthase [Bacillus anthracis s...

352

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZSJ

58%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02726
(show subtarget assignments)

1

cloned

No

GBAA4229

47529522

maltosaccharide ABC transporter, maltosa...

419

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZYK

41.5%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02377
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1442

47526717

cysC

adenylylsulfate kinase [Bacillus anthrac...

197

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UIE

51.3%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP01917
(show subtarget assignments)

1

soluble

No

GBAA1429

47526701

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

239

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VZW

36.5%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

Targets