Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90437 (show subtarget assignments)	8	cloned	No	CT_869	3329344	pmpE	Putative Outer Membrane Protein E [Chlam...	964	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90434 (show subtarget assignments)	8	cloned	No	CT_870	3329345	pmpF	Putative Outer Membrane Protein F [Chlam...	1034	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90435 (show subtarget assignments)	8	cloned	No	CT_871	3329346	pmpG	Putative Outer Membrane Protein G [Chlam...	1013	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90436 (show subtarget assignments)	8	cloned	No	CT_872	3329347	pmpH	Putative Outer Membrane Protein H [Chlam...	1016	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90331 (show subtarget assignments)	8	selected	No	CT_874	3329350	pmpI	Putative Outer Membrane Protein I [Chlam...	878	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91676 (show subtarget assignments)	8	selected	No	DNJA3_HUMAN	0			480	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	3LZ8	19.6%	Homo sapiens

IDP91045 (show subtarget assignments)	8	cloned	No	ECH0010	15799700		hypothetical protein Z0021 [Escherichia ...	108	virulence/pathogenesis / Hypothetical protein Z0021 is involved in regulation of swimming motility in E. ...	Community Requests			Escherichia coli

IDP90972 (show subtarget assignments)	8	selected	No	ECO103_4485	260846542	tisB	lexA-regulated toxic peptide [Escherichi...	29	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP92246 (show subtarget assignments)	8	selected	No	EF_2296	2499116		RecName: Full=Vancomycin B-type resistan...	275	drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...	Community Requests			Enterococcus faecalis

IDP91044 (show subtarget assignments)	8	in_crystallization_trials	No	EFA0002	110556113	vanY	vanY [Enterococcus faecalis]	303	drug resistance / A carboxypeptidase thought to be involved in breakdown of normal cell wall	Community Requests			Enterococcus faecalis

IDP91047 (show subtarget assignments)	8	in_crystallization_trials	No	EFA0003	5353563	vanRD	response regulator [Enterococcus faecium...	232	drug resistance / Component of regulatory system of transcription of vancomycin resistance genes	Community Requests	2GWR	37.1%	Enterococcus faecium

IDP91190 (show subtarget assignments)	1	in_crystallization_trials	No	EF_A0061	29345308		6'-aminoglycoside N-acetyltransferase [E...	479	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R6Z	20%	Enterococcus faecalis

IDP91547 (show subtarget assignments)	8	selected	No	EfaeDRAFT_0205	69249189		Protein of unknown function DUF470:Prote...	866	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Enterococcus faecium

IDP91548 (show subtarget assignments)	8	selected	No	EfaeDRAFT_1579	69245409		Protein of unknown function DUF472 [Ente...	857	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Enterococcus faecium

IDP91050 (show subtarget assignments)	8	in_crystallization_trials	No	EFE0001	1209531	vanB	D-Ala:D-Lac ligase [Enterococcus faecali...	342	drug resistance / D-lactate D-ala ligase; generates vancomycin resistant cell wall	Community Requests	1E4E	75.1%	Enterococcus faecalis

IDP91041 (show subtarget assignments)	8	in_pdb 3TYS 3TYR	No	EFE0002	33355847	vanUG	predicted transcriptional regulator [Ent...	75	drug resistance / Putative transcriptional regulator	Community Requests	3T75	89.3%	Enterococcus faecalis

IDP91043 (show subtarget assignments)	8	in_crystallization_trials	No	EFE0003	33355848	vanRG	response regulator [Enterococcus faecali...	235	drug resistance / Component of regulatory system of transcription of vancomycin resistance genes	Community Requests	1P2F	37%	Enterococcus faecalis

IDP91046 (show subtarget assignments)	8	in_pdb 4ECL	No	EFE0004	33355854	vanTG	serine racemase [Enterococcus faecalis]	712	drug resistance / Putative serine racemase involved in synthesis of D-Ala-D-Ser, a component of va...	Community Requests	4ECL	52.5%	Enterococcus faecalis

IDP91049 (show subtarget assignments)	8	in_crystallization_trials	No	EFE0005	160947043	vanTrL	serine racemase [Enterococcus faecalis]	366	drug resistance / Soluble component of serine racemase involved in synthesis of vancomycin resista...	Community Requests	4ECL	42.6%	Enterococcus faecalis

IDP91048 (show subtarget assignments)	8	in_crystallization_trials	No	EGA0001	4545123	vanT	serine racemase VanT [Enterococcus galli...	698	drug resistance / Serine racemase involved in synthesis of D-Ala-D-Ser, a component of vancomycin ...	Community Requests	4ECL	22.3%	Enterococcus gallinarum

IDP91053 (show subtarget assignments)	8	in_crystallization_trials	No	ENC0002	0			247	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3B89	42.1%	Enterobacter cloacae

IDP91677 (show subtarget assignments)	8	selected	No	FLUAVs7gp1	8486123	M1	matrix protein 1 [Influenza A virus (A/P...	252	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1EA3	65.1%	Influenza A

IDP92250 (show subtarget assignments)	8	selected	No	FTL_0803	89256173		hypothetical protein FTL_0803 [Francisel...	127	virulence/pathogenesis / We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...	Community Requests			Francisella tularensis

IDP91540 (show subtarget assignments)	8	selected	No	FTN_0549	118423054	sspA	stringent starvation protein A [Francise...	210	virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.	Community Requests	3LYK	31.4%	Francisella novicida

IDP92557 (show subtarget assignments)	8	selected	No	FTN_0757	118497352		membrane protein [Francisella novicida U...	1629	virulence/pathogenesis / We have shown that this protein plays a role in virulence in Francisella novicid...	Community Requests			Francisella novicida

IDP92006 (show subtarget assignments)	8	selected	No	FTN_0818	118497410		lipase/esterase [Francisella novicida U1...	306	virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...	Community Requests	3AIK	33.3%	Francisella novicida

IDP92248 (show subtarget assignments)	8	selected	No	FTN_1133	118497723		hypothetical protein FTN_1133 [Francisel...	127	virulence/pathogenesis / We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...	Community Requests			Francisella novicida

IDP91539 (show subtarget assignments)	8	selected	No	FTN_1290	118423781	mglA	macrophage growth locus, protein A [Fran...	205	virulence/pathogenesis / MglA regulates transcription of virulence factors necessary for Francisella tula...	Community Requests	3MDK	25.4%	Francisella novicida

IDP04633 (show subtarget assignments)	1	in_pdb 4EEI	No	FTT0015	56707195	purB	adenylosuccinate lyase [Francisella tula...	432	conserved gene; putative drug target function;	Phase 4: April 2009	4EEI	100%	Francisella tularensis

IDP04295 (show subtarget assignments)	1	cloned	No	FTT0031	56707211	nuoA	NADH dehydrogenase I, A subunit [Francis...	132	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RKO	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP02178 (show subtarget assignments)	1	soluble	No	FTT0032	56707212	nuoB	NADH dehydrogenase subunit B [Francisell...	158	Drug Target	Phase 3: June 2008	2FUG	53.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP04417 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0033	56707213	nuoC	NADH dehydrogenase I [Francisella tulare...	216	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2FUG	21.8%	Francisella tularensis

IDP02299 (show subtarget assignments)	1	cloned	No	FTT0034	56707214	nuoD	NADH dehydrogenase subunit D [Francisell...	417	Drug Target	Phase 3: June 2008	2FUG	42.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02316 (show subtarget assignments)	1	soluble	No	FTT0037	56707217	nuoG	NADH dehydrogenase subunit G [Francisell...	788	Conserved; Drug target functions	Phase 3: June 2008	2FUG	24.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02723 (show subtarget assignments)	1	cloned	No	FTT0039	56707219	nuoI	NADH dehydrogenase subunit I [Francisell...	162	Conserved; Drug target functions	Phase 3: June 2008	2FUG	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP02017 (show subtarget assignments)	1	soluble	No	FTT0047	56707226	hemE	uroporphyrinogen decarboxylase [Francise...	344	Conserved; Drug target functions	Phase 3: June 2008	3CYV	47.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01933 (show subtarget assignments)	1	soluble	No	FTT0061	56707240	atpH	F0F1 ATP synthase subunit delta [Francis...	174	Conserved; Drug target functions	Phase 3: June 2008	2WSS	28.2%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP01802 (show subtarget assignments)	1	crystallized	No	FTT0062	56707241	atpA	F0F1 ATP synthase subunit alpha [Francis...	513	Conserved; Drug target functions	Phase 3: June 2008	3OAA	71%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02177 (show subtarget assignments)	1	soluble	No	FTT0063	56707242	atpG	F0F1 ATP synthase subunit gamma [Francis...	298	Conserved; Drug target functions	Phase 3: June 2008	3OAA	49.7%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02648 (show subtarget assignments)	1	soluble	No	FTT0064	56707243	atpD	F0F1 ATP synthase subunit beta [Francise...	458	Conserved; Drug target functions	Phase 3: June 2008	3OAA	81.3%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02182 (show subtarget assignments)	1	cloned	No	FTT0065	56707244	atpC	F0F1 ATP synthase subunit epsilon [Franc...	145	Conserved; Drug target functions	Phase 3: June 2008	2QE7	33.1%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP01808 (show subtarget assignments)	1	in_pdb 3H1S	Yes	FTT0068	56707247	sodB	superoxide dismutase (Fe) [Francisella t...	192	Drug Target	Phase 3: June 2008	3H1S	100%	Francisella tularensis	Cellular processes	Detoxification

IDP04634 (show subtarget assignments)	1	in_pdb 3MSU	No	FTT0071c	56707250	gltA	citrate synthase [Francisella tularensis...	424	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3MSU	100%	Francisella tularensis

IDP04070 (show subtarget assignments)	1	cloned	No	FTT0073	56707252	sdhD	succinate dehydrogenase hydrophobic memb...	122	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NEK	26.2%	Francisella tularensis

IDP02644 (show subtarget assignments)	1	purified	No	FTT0074	56707253	sdhA	succinate dehydrogenase, catalytic and N...	597	Conserved; Drug target functions	Phase 3: June 2008	1NEK	61.4%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02194 (show subtarget assignments)	1	expressed	No	FTT0075	56707254	sdhB	succinate dehydrogenase iron-sulfur subu...	233	Conserved; Drug target functions	Phase 3: June 2008	1NEK	66.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP04395 (show subtarget assignments)	1	cloned	No	FTT0076	56707255	sucA	2-oxoglutarate dehydrogenase E1 componen...	941	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2JGD	47.8%	Francisella tularensis

IDP02321 (show subtarget assignments)	1	cloned	No	FTT0077	56707256	sucB	dihydrolipoamide succinyltransferase com...	489	Conserved; Drug target functions	Phase 3: June 2008	1C4T	29.9%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02164 (show subtarget assignments)	1	in_pdb 3I3W	Yes	FTT0079	56707258	mrsA	phosphoglucosamine mutase [Francisella t...	443	Conserved; Drug target functions	Phase 3: June 2008	3I3W	100%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02082 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0080	56707259	tpiA	triosephosphate isomerase [Francisella t...	253	Conserved; Drug target functions	Phase 3: June 2008	1TMH	42.7%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02195 (show subtarget assignments)	1	expressed	No	FTT0084c	56707262	hemN	oxygen-independent coproporphyrinogen II...	380	Conserved; Drug target functions	Phase 3: June 2008	1OLT	22.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02744 (show subtarget assignments)	1	cloned	No	FTT0087	56707265	acnA	aconitate hydratase [Francisella tularen...	937	Drug Target	Phase 3: June 2008	3SN2	50.5%	Francisella tularensis	Energy metabolism	TCA cycle

IDP90001 (show subtarget assignments)	8	cloned	No	FTT0094c	56603762	qseC	sensor histidine kinase	475	Drug Target (Community Request)	Community Requests	3A0R	15.8%	Francisella tularensis

IDP04635 (show subtarget assignments)	1	soluble	No	FTT0101	56603768		conserved membrane hypothetical protein ...	337	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4E94	25.5%	Francisella tularensis

IDP91077 (show subtarget assignments)	8	cloned	No	FTT_0109	56707283	msbA	Lipid A transport protein, ABC transport...	609	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5W	41.2%	Francisella tularensis

IDP02285 (show subtarget assignments)	1	soluble	No	FTT0132	56707303	glpA	anaerobic glycerol-3-phosphate dehydroge...	510	Drug Target	Phase 3: June 2008	3DA1	33.1%	Francisella tularensis	Energy metabolism	Other

IDP02747 (show subtarget assignments)	1	soluble	No	FTT0147	56707317	gcp	O-sialoglycoprotein endopeptidase [Franc...	336	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2IVN	35.1%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04570 (show subtarget assignments)	1	soluble	No	FTT0153	56707323	rplS	50S ribosomal protein L19 [Francisella t...	115	drug target; conserved gene;	Phase 4: April 2009	1VS6	58.3%	Francisella tularensis	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP01914 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0160	56707330	nudH	dinucleoside polyphosphate hydrolase [Fr...	155	Drug Target	Phase 3: June 2008	2KDV	54.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02161 (show subtarget assignments)	1	soluble	No	FTT0162	56707332	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	174	Drug Target	Phase 3: June 2008	1J3G	47.7%	Francisella tularensis	Cellular processes	Toxin production and resistance

IDP02291 (show subtarget assignments)	1	cloned	No	FTT0167	56707337	hemA	glutamyl-tRNA reductase [Francisella tul...	416	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	26.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02693 (show subtarget assignments)	1	crystallized	No	FTT0185	56707350	ddlB	D-alanine--D-alanine ligase B [Francisel...	296	Conserved; Drug target functions	Phase 3: June 2008	3V4Z	43.9%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02098 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0187	56707352	ftsA	cell division protein FtsA [Francisella ...	420	Conserved; Drug target functions	Phase 3: June 2008	1E4F	24%	Francisella tularensis	Cellular processes	Cell division

IDP02166 (show subtarget assignments)	1	cloned	No	FTT0188	56707353	ftsZ	cell division protein FtsZ [Francisella ...	381	Conserved; Drug target functions	Phase 3: June 2008	2VAW	55.9%	Francisella tularensis	Cellular processes	Cell division

IDP02302 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0203c	56707367	purH	bifunctional phosphoribosylaminoimidazol...	515	Drug Target	Phase 3: June 2008	3ZZM	47.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04636 (show subtarget assignments)	1	soluble	No	FTT0238	56707395	aroE1	shikimate 5-dehydrogenase [Francisella t...	257	drug target; conserved gene;	Phase 4: April 2009	3O8Q	36.8%	Francisella tularensis

IDP02309 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0239	56707396	murC	UDP-N-acetylmuramate--alanine ligase [Fr...	451	Conserved; Drug target functions	Phase 3: June 2008	2F00	36.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02020 (show subtarget assignments)	1	crystallized	No	FTT0245	56707402	usp	universal stress protein [Francisella tu...	278	Drug Target	Phase 3: June 2008	2PFS	20.5%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02317 (show subtarget assignments)	1	cloned	No	FTT0256c	56707412		lipopolysaccharide protein [Francisella ...	322	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01809 (show subtarget assignments)	1	purified	No	FTT0258	56707414		carboxylesterase/phospholipase family pr...	222	Drug Target	Phase 3: June 2008	1FJ2	39.6%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP02205 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0259	56707415	hemC	hydroxymethylbilane synthase (porphobili...	300	Conserved; Drug target functions	Phase 3: June 2008	1AH5	54.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01928 (show subtarget assignments)	1	cloned	No	FTT0286c	56707440	lpxD1	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	347	Drug Target	Phase 3: June 2008	2IU8	33.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02769 (show subtarget assignments)	1	cloned	No	FTT0304c	56707457	nfnB	dihydropteridine reductase [Francisella ...	217	Drug Target	Phase 3: June 2008	3HZN	45.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP02169 (show subtarget assignments)	1	soluble	No	FTT0306	56707459	fumC	fumarate hydratase [Francisella tularens...	463	Conserved; Drug target functions	Phase 3: June 2008	3E04	55.3%	Francisella tularensis	Energy metabolism	TCA cycle

IDP04276 (show subtarget assignments)	1	soluble	No	FTT0312c	56707465	folA	dihydrofolate reductase type I [Francise...	166	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JW3	41.6%	Francisella tularensis

IDP01822 (show subtarget assignments)	1	cloned	No	FTT0317	56707470	uppS	undecaprenyl pyrophosphate synthetase [F...	257	Conserved; Drug target functions	Phase 3: June 2008	1JP3	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02344 (show subtarget assignments)	1	cloned	No	FTT0356	56707508	htpG	heat shock protein 90 [Francisella tular...	628	Conserved; Drug target functions	Phase 3: June 2008	2IOP	52.4%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein folding and stabilization

IDP02121 (show subtarget assignments)	1	cloned	No	FTT0360	56707511		Short-chain dehydrogenase/reductase [Fra...	274	Drug Target	Phase 3: June 2008	1FDW	27.7%	Francisella tularensis	Central intermediary metabolism	Other

IDP01828 (show subtarget assignments)	1	in_pdb 3NZT	Yes	FTT0367c	56707518	gshA	glutamate--cysteine ligase [Francisella ...	501	Drug Target	Phase 3: June 2008	3NZT	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP04637 (show subtarget assignments)	1	cloned	No	FTT0371c	56707522	folC	FolC bifunctional protein [Francisella t...	393	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1W78	29.8%	Francisella tularensis

IDP04638 (show subtarget assignments)	1	expressed	No	FTT0372c	56707523	accD	Acetyl-CoA carboxylase beta subunit [Fra...	302	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	60.3%	Francisella tularensis

IDP02698 (show subtarget assignments)	1	purified	No	FTT0387	56707536	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3FWW	51%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00340 (show subtarget assignments)	1	in_pdb 3TBF	No	FTT0388	56707537	glmS	Glucosamine--fructose-6-phosphate aminot...	612	Drug Target Function	Phase 2: March 2008	3TBF	60.8%	Francisella tularensis	Central intermediary metabolism	Amino sugars

IDP02334 (show subtarget assignments)	1	soluble	No	FTT0391c	56707540	cspC	cold shock protein [Francisella tularens...	67	Drug Target	Phase 3: June 2008	3I2Z	61.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02774 (show subtarget assignments)	1	soluble	No	FTT0392c	56707541		hypothetical protein FTT0392c [Francisel...	109	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02686 (show subtarget assignments)	1	soluble	No	FTT0393	56707542	map	methionine aminopeptidase [Francisella t...	256	Conserved; Drug target functions; Drug target motif	Community Interest	1C21	59.4%	Francisella tularensis	N/A	N/A

IDP02365 (show subtarget assignments)	1	purified	No	FTT0403	56707552	def1	peptide deformylase [Francisella tularen...	211	Conserved; Drug target functions	Phase 3: June 2008	3M6O	28.4%	Francisella tularensis	Protein fate	Protein modification and repair

IDP02684 (show subtarget assignments)	1	cloned	No	FTT0405	56707554	lolD	lipoprotein releasing system, subunit D,...	231	Conserved; Drug target functions	Phase 3: June 2008	1F3O	44.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01830 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0407	56707556	gcvT	glycine cleavage system aminomethyltrans...	358	Drug Target	Phase 3: June 2008	1VLO	47.9%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02185 (show subtarget assignments)	1	selected	No	FTT0408	56707557	gcvH	glycine cleavage system H protein [Franc...	127	Drug Target	Phase 3: June 2008	3A7A	59.8%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02183 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0414	56707563	pgm	phosphoglucomutase [Francisella tularens...	544	Drug Target	Phase 3: June 2008	1C47	54.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02368 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0422	56707569	murF	UDP-N--acetylmuramoylalanyl-D-glutamyl-2...	452	Conserved; Drug target functions	Phase 3: June 2008	1GG4	33.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02783 (show subtarget assignments)	1	expressed	No	FTT0425c	56707572	asd	aspartate-semialdehyde dehydrogenase [Fr...	364	Conserved; Drug target functions	Phase 3: June 2008	1NWC	50%	Francisella tularensis	Amino acid biosynthesis	Aspartate family

IDP02311 (show subtarget assignments)	1	in_pdb 3MJD	Yes	FTT0437c	56707581	pyrE	orotate phosphoribosyltransferase [Franc...	208	Drug Target	Phase 3: June 2008	3MJD	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02373 (show subtarget assignments)	1	expressed	No	FTT0438	56707582	mpl	UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	456	Conserved; Drug target functions	Phase 3: June 2008	3HN7	41.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02376 (show subtarget assignments)	1	cloned	No	FTT0451	56707593	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	416	Conserved; Drug target functions	Phase 3: June 2008	1E0D	31.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04026 (show subtarget assignments)	1	expressed	No	FTT0456c	56707598		hypothetical protein FTT_0456c [Francise...	97	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YHD	39.2%	Francisella tularensis

IDP91217 (show subtarget assignments)	1	expressed	No	FTT_0458	56707600	sspA	stringent starvation protein A, regulato...	210	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LYK	31.4%	Francisella tularensis

IDP91058 (show subtarget assignments)	8	soluble	No	FTT_0468	56707610	surA	peptidyl-prolyl cis-trans isomerase (PPI...	473	virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...	Community Requests	1M5Y	19.5%	Francisella tularensis

IDP90437
(show subtarget assignments)

8

cloned

No

CT_869

3329344

pmpE

Putative Outer Membrane Protein E [Chlam...

964

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90434
(show subtarget assignments)

8

cloned

No

CT_870

3329345

pmpF

Putative Outer Membrane Protein F [Chlam...

1034

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90435
(show subtarget assignments)

8

cloned

No

CT_871

3329346

pmpG

Putative Outer Membrane Protein G [Chlam...

1013

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90436
(show subtarget assignments)

8

cloned

No

CT_872

3329347

pmpH

Putative Outer Membrane Protein H [Chlam...

1016

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90331
(show subtarget assignments)

8

selected

No

CT_874

3329350

pmpI

Putative Outer Membrane Protein I [Chlam...

878

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP91676
(show subtarget assignments)

8

selected

No

DNJA3_HUMAN

0

480

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

3LZ8

19.6%

Homo sapiens

IDP91045
(show subtarget assignments)

8

cloned

No

ECH0010

15799700

hypothetical protein Z0021 [Escherichia ...

108

virulence/pathogenesis / Hypothetical protein Z0021 is involved in regulation of swimming motility in E. ...

Community Requests

Escherichia coli

IDP90972
(show subtarget assignments)

8

selected

No

ECO103_4485

260846542

tisB

lexA-regulated toxic peptide [Escherichi...

29

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP92246
(show subtarget assignments)

8

selected

No

EF_2296

2499116

RecName: Full=Vancomycin B-type resistan...

275

drug resistance / Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...

Community Requests

Enterococcus faecalis

IDP91044
(show subtarget assignments)

8

in_crystallization_trials

No

EFA0002

110556113

vanY

vanY [Enterococcus faecalis]

303

drug resistance / A carboxypeptidase thought to be involved in breakdown of normal cell wall

Community Requests

Enterococcus faecalis

IDP91047
(show subtarget assignments)

8

in_crystallization_trials

No

EFA0003

5353563

vanRD

response regulator [Enterococcus faecium...

232

drug resistance / Component of regulatory system of transcription of vancomycin resistance genes

Community Requests

2GWR

37.1%

Enterococcus faecium

IDP91190
(show subtarget assignments)

1

in_crystallization_trials

No

EF_A0061

29345308

6'-aminoglycoside N-acetyltransferase [E...

479

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R6Z

20%

Enterococcus faecalis

IDP91547
(show subtarget assignments)

8

selected

No

EfaeDRAFT_0205

69249189

Protein of unknown function DUF470:Prote...

866

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Enterococcus faecium

IDP91548
(show subtarget assignments)

8

selected

No

EfaeDRAFT_1579

69245409

Protein of unknown function DUF472 [Ente...

857

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Enterococcus faecium

IDP91050
(show subtarget assignments)

8

in_crystallization_trials

No

EFE0001

1209531

vanB

D-Ala:D-Lac ligase [Enterococcus faecali...

342

drug resistance / D-lactate D-ala ligase; generates vancomycin resistant cell wall

Community Requests

1E4E

75.1%

Enterococcus faecalis

IDP91041
(show subtarget assignments)

8

in_pdb
3TYS
3TYR

No

EFE0002

33355847

vanUG

predicted transcriptional regulator [Ent...

75

drug resistance / Putative transcriptional regulator

Community Requests

3T75

89.3%

Enterococcus faecalis

IDP91043
(show subtarget assignments)

8

in_crystallization_trials

No

EFE0003

33355848

vanRG

response regulator [Enterococcus faecali...

235

drug resistance / Component of regulatory system of transcription of vancomycin resistance genes

Community Requests

1P2F

37%

Enterococcus faecalis

IDP91046
(show subtarget assignments)

8

in_pdb
4ECL

No

EFE0004

33355854

vanTG

serine racemase [Enterococcus faecalis]

712

drug resistance / Putative serine racemase involved in synthesis of D-Ala-D-Ser, a component of va...

Community Requests

4ECL

52.5%

Enterococcus faecalis

IDP91049
(show subtarget assignments)

8

in_crystallization_trials

No

EFE0005

160947043

vanTrL

serine racemase [Enterococcus faecalis]

366

drug resistance / Soluble component of serine racemase involved in synthesis of vancomycin resista...

Community Requests

4ECL

42.6%

Enterococcus faecalis

IDP91048
(show subtarget assignments)

8

in_crystallization_trials

No

EGA0001

4545123

vanT

serine racemase VanT [Enterococcus galli...

698

drug resistance / Serine racemase involved in synthesis of D-Ala-D-Ser, a component of vancomycin ...

Community Requests

4ECL

22.3%

Enterococcus gallinarum

IDP91053
(show subtarget assignments)

8

in_crystallization_trials

No

ENC0002

0

247

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3B89

42.1%

Enterobacter cloacae

IDP91677
(show subtarget assignments)

8

selected

No

FLUAVs7gp1

8486123

M1

matrix protein 1 [Influenza A virus (A/P...

252

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1EA3

65.1%

Influenza A

IDP92250
(show subtarget assignments)

8

selected

No

FTL_0803

89256173

hypothetical protein FTL_0803 [Francisel...

127

virulence/pathogenesis / We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...

Community Requests

Francisella tularensis

IDP91540
(show subtarget assignments)

8

selected

No

FTN_0549

118423054

sspA

stringent starvation protein A [Francise...

210

virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.

Community Requests

3LYK

31.4%

Francisella novicida

IDP92557
(show subtarget assignments)

8

selected

No

FTN_0757

118497352

membrane protein [Francisella novicida U...

1629

virulence/pathogenesis / We have shown that this protein plays a role in virulence in Francisella novicid...

Community Requests

Francisella novicida

IDP92006
(show subtarget assignments)

8

selected

No

FTN_0818

118497410

lipase/esterase [Francisella novicida U1...

306

virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...

Community Requests

3AIK

33.3%

Francisella novicida

IDP92248
(show subtarget assignments)

8

selected

No

FTN_1133

118497723

hypothetical protein FTN_1133 [Francisel...

127

virulence/pathogenesis / We recently described FTN_1133/FTL_0803/FTT_1152 as an important virulence facto...

Community Requests

Francisella novicida

IDP91539
(show subtarget assignments)

8

selected

No

FTN_1290

118423781

mglA

macrophage growth locus, protein A [Fran...

205

virulence/pathogenesis / MglA regulates transcription of virulence factors necessary for Francisella tula...

Community Requests

3MDK

25.4%

Francisella novicida

IDP04633
(show subtarget assignments)

1

in_pdb
4EEI

No

FTT0015

56707195

purB

adenylosuccinate lyase [Francisella tula...

432

conserved gene; putative drug target function;

Phase 4: April 2009

4EEI

100%

Francisella tularensis

IDP04295
(show subtarget assignments)

1

cloned

No

FTT0031

56707211

nuoA

NADH dehydrogenase I, A subunit [Francis...

132

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RKO

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP02178
(show subtarget assignments)

1

soluble

No

FTT0032

56707212

nuoB

NADH dehydrogenase subunit B [Francisell...

158

Drug Target

Phase 3: June 2008

2FUG

53.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP04417
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0033

56707213

nuoC

NADH dehydrogenase I [Francisella tulare...

216

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2FUG

21.8%

Francisella tularensis

IDP02299
(show subtarget assignments)

1

cloned

No

FTT0034

56707214

nuoD

NADH dehydrogenase subunit D [Francisell...

417

Drug Target

Phase 3: June 2008

2FUG

42.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02316
(show subtarget assignments)

1

soluble

No

FTT0037

56707217

nuoG

NADH dehydrogenase subunit G [Francisell...

788

Conserved; Drug target functions

Phase 3: June 2008

2FUG

24.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02723
(show subtarget assignments)

1

cloned

No

FTT0039

56707219

nuoI

NADH dehydrogenase subunit I [Francisell...

162

Conserved; Drug target functions

Phase 3: June 2008

2FUG

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP02017
(show subtarget assignments)

1

soluble

No

FTT0047

56707226

hemE

uroporphyrinogen decarboxylase [Francise...

344

Conserved; Drug target functions

Phase 3: June 2008

3CYV

47.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01933
(show subtarget assignments)

1

soluble

No

FTT0061

56707240

atpH

F0F1 ATP synthase subunit delta [Francis...

174

Conserved; Drug target functions

Phase 3: June 2008

2WSS

28.2%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP01802
(show subtarget assignments)

1

crystallized

No

FTT0062

56707241

atpA

F0F1 ATP synthase subunit alpha [Francis...

513

Conserved; Drug target functions

Phase 3: June 2008

3OAA

71%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02177
(show subtarget assignments)

1

soluble

No

FTT0063

56707242

atpG

F0F1 ATP synthase subunit gamma [Francis...

298

Conserved; Drug target functions

Phase 3: June 2008

3OAA

49.7%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02648
(show subtarget assignments)

1

soluble

No

FTT0064

56707243

atpD

F0F1 ATP synthase subunit beta [Francise...

458

Conserved; Drug target functions

Phase 3: June 2008

3OAA

81.3%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02182
(show subtarget assignments)

1

cloned

No

FTT0065

56707244

atpC

F0F1 ATP synthase subunit epsilon [Franc...

145

Conserved; Drug target functions

Phase 3: June 2008

2QE7

33.1%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP01808
(show subtarget assignments)

1

in_pdb
3H1S

Yes

FTT0068

56707247

sodB

superoxide dismutase (Fe) [Francisella t...

192

Drug Target

Phase 3: June 2008

3H1S

100%

Francisella tularensis

Cellular processes

Detoxification

IDP04634
(show subtarget assignments)

1

in_pdb
3MSU

No

FTT0071c

56707250

gltA

citrate synthase [Francisella tularensis...

424

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3MSU

100%

Francisella tularensis

IDP04070
(show subtarget assignments)

1

cloned

No

FTT0073

56707252

sdhD

succinate dehydrogenase hydrophobic memb...

122

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NEK

26.2%

Francisella tularensis

IDP02644
(show subtarget assignments)

1

purified

No

FTT0074

56707253

sdhA

succinate dehydrogenase, catalytic and N...

597

Conserved; Drug target functions

Phase 3: June 2008

1NEK

61.4%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02194
(show subtarget assignments)

1

expressed

No

FTT0075

56707254

sdhB

succinate dehydrogenase iron-sulfur subu...

233

Conserved; Drug target functions

Phase 3: June 2008

1NEK

66.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP04395
(show subtarget assignments)

1

cloned

No

FTT0076

56707255

sucA

2-oxoglutarate dehydrogenase E1 componen...

941

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2JGD

47.8%

Francisella tularensis

IDP02321
(show subtarget assignments)

1

cloned

No

FTT0077

56707256

sucB

dihydrolipoamide succinyltransferase com...

489

Conserved; Drug target functions

Phase 3: June 2008

1C4T

29.9%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02164
(show subtarget assignments)

1

in_pdb
3I3W

Yes

FTT0079

56707258

mrsA

phosphoglucosamine mutase [Francisella t...

443

Conserved; Drug target functions

Phase 3: June 2008

3I3W

100%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02082
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0080

56707259

tpiA

triosephosphate isomerase [Francisella t...

253

Conserved; Drug target functions

Phase 3: June 2008

1TMH

42.7%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02195
(show subtarget assignments)

1

expressed

No

FTT0084c

56707262

hemN

oxygen-independent coproporphyrinogen II...

380

Conserved; Drug target functions

Phase 3: June 2008

1OLT

22.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02744
(show subtarget assignments)

1

cloned

No

FTT0087

56707265

acnA

aconitate hydratase [Francisella tularen...

937

Drug Target

Phase 3: June 2008

3SN2

50.5%

Francisella tularensis

Energy metabolism

TCA cycle

IDP90001
(show subtarget assignments)

8

cloned

No

FTT0094c

56603762

qseC

sensor histidine kinase

475

Drug Target (Community Request)

Community Requests

3A0R

15.8%

Francisella tularensis

IDP04635
(show subtarget assignments)

1

soluble

No

FTT0101

56603768

conserved membrane hypothetical protein ...

337

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4E94

25.5%

Francisella tularensis

IDP91077
(show subtarget assignments)

8

cloned

No

FTT_0109

56707283

msbA

Lipid A transport protein, ABC transport...

609

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5W

41.2%

Francisella tularensis

IDP02285
(show subtarget assignments)

1

soluble

No

FTT0132

56707303

glpA

anaerobic glycerol-3-phosphate dehydroge...

510

Drug Target

Phase 3: June 2008

3DA1

33.1%

Francisella tularensis

Energy metabolism

Other

IDP02747
(show subtarget assignments)

1

soluble

No

FTT0147

56707317

gcp

O-sialoglycoprotein endopeptidase [Franc...

336

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2IVN

35.1%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04570
(show subtarget assignments)

1

soluble

No

FTT0153

56707323

rplS

50S ribosomal protein L19 [Francisella t...

115

drug target; conserved gene;

Phase 4: April 2009

1VS6

58.3%

Francisella tularensis

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP01914
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0160

56707330

nudH

dinucleoside polyphosphate hydrolase [Fr...

155

Drug Target

Phase 3: June 2008

2KDV

54.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02161
(show subtarget assignments)

1

soluble

No

FTT0162

56707332

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

174

Drug Target

Phase 3: June 2008

1J3G

47.7%

Francisella tularensis

Cellular processes

Toxin production and resistance

IDP02291
(show subtarget assignments)

1

cloned

No

FTT0167

56707337

hemA

glutamyl-tRNA reductase [Francisella tul...

416

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

26.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02693
(show subtarget assignments)

1

crystallized

No

FTT0185

56707350

ddlB

D-alanine--D-alanine ligase B [Francisel...

296

Conserved; Drug target functions

Phase 3: June 2008

3V4Z

43.9%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02098
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0187

56707352

ftsA

cell division protein FtsA [Francisella ...

420

Conserved; Drug target functions

Phase 3: June 2008

1E4F

24%

Francisella tularensis

Cellular processes

Cell division

IDP02166
(show subtarget assignments)

1

cloned

No

FTT0188

56707353

ftsZ

cell division protein FtsZ [Francisella ...

381

Conserved; Drug target functions

Phase 3: June 2008

2VAW

55.9%

Francisella tularensis

Cellular processes

Cell division

IDP02302
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0203c

56707367

purH

bifunctional phosphoribosylaminoimidazol...

515

Drug Target

Phase 3: June 2008

3ZZM

47.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04636
(show subtarget assignments)

1

soluble

No

FTT0238

56707395

aroE1

shikimate 5-dehydrogenase [Francisella t...

257

drug target; conserved gene;

Phase 4: April 2009

3O8Q

36.8%

Francisella tularensis

IDP02309
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0239

56707396

murC

UDP-N-acetylmuramate--alanine ligase [Fr...

451

Conserved; Drug target functions

Phase 3: June 2008

2F00

36.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02020
(show subtarget assignments)

1

crystallized

No

FTT0245

56707402

usp

universal stress protein [Francisella tu...

278

Drug Target

Phase 3: June 2008

2PFS

20.5%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02317
(show subtarget assignments)

1

cloned

No

FTT0256c

56707412

lipopolysaccharide protein [Francisella ...

322

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01809
(show subtarget assignments)

1

purified

No

FTT0258

56707414

carboxylesterase/phospholipase family pr...

222

Drug Target

Phase 3: June 2008

1FJ2

39.6%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP02205
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0259

56707415

hemC

hydroxymethylbilane synthase (porphobili...

300

Conserved; Drug target functions

Phase 3: June 2008

1AH5

54.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01928
(show subtarget assignments)

1

cloned

No

FTT0286c

56707440

lpxD1

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

347

Drug Target

Phase 3: June 2008

2IU8

33.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02769
(show subtarget assignments)

1

cloned

No

FTT0304c

56707457

nfnB

dihydropteridine reductase [Francisella ...

217

Drug Target

Phase 3: June 2008

3HZN

45.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP02169
(show subtarget assignments)

1

soluble

No

FTT0306

56707459

fumC

fumarate hydratase [Francisella tularens...

463

Conserved; Drug target functions

Phase 3: June 2008

3E04

55.3%

Francisella tularensis

Energy metabolism

TCA cycle

IDP04276
(show subtarget assignments)

1

soluble

No

FTT0312c

56707465

folA

dihydrofolate reductase type I [Francise...

166

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JW3

41.6%

Francisella tularensis

IDP01822
(show subtarget assignments)

1

cloned

No

FTT0317

56707470

uppS

undecaprenyl pyrophosphate synthetase [F...

257

Conserved; Drug target functions

Phase 3: June 2008

1JP3

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02344
(show subtarget assignments)

1

cloned

No

FTT0356

56707508

htpG

heat shock protein 90 [Francisella tular...

628

Conserved; Drug target functions

Phase 3: June 2008

2IOP

52.4%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein folding and stabilization

IDP02121
(show subtarget assignments)

1

cloned

No

FTT0360

56707511

Short-chain dehydrogenase/reductase [Fra...

274

Drug Target

Phase 3: June 2008

1FDW

27.7%

Francisella tularensis

Central intermediary metabolism

Other

IDP01828
(show subtarget assignments)

1

in_pdb
3NZT

Yes

FTT0367c

56707518

gshA

glutamate--cysteine ligase [Francisella ...

501

Drug Target

Phase 3: June 2008

3NZT

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP04637
(show subtarget assignments)

1

cloned

No

FTT0371c

56707522

folC

FolC bifunctional protein [Francisella t...

393

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1W78

29.8%

Francisella tularensis

IDP04638
(show subtarget assignments)

1

expressed

No

FTT0372c

56707523

accD

Acetyl-CoA carboxylase beta subunit [Fra...

302

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

60.3%

Francisella tularensis

IDP02698
(show subtarget assignments)

1

purified

No

FTT0387

56707536

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3FWW

51%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00340
(show subtarget assignments)

1

in_pdb
3TBF

No

FTT0388

56707537

glmS

Glucosamine--fructose-6-phosphate aminot...

612

Drug Target Function

Phase 2: March 2008

3TBF

60.8%

Francisella tularensis

Central intermediary metabolism

Amino sugars

IDP02334
(show subtarget assignments)

1

soluble

No

FTT0391c

56707540

cspC

cold shock protein [Francisella tularens...

67

Drug Target

Phase 3: June 2008

3I2Z

61.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02774
(show subtarget assignments)

1

soluble

No

FTT0392c

56707541

hypothetical protein FTT0392c [Francisel...

109

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02686
(show subtarget assignments)

1

soluble

No

FTT0393

56707542

map

methionine aminopeptidase [Francisella t...

256

Conserved; Drug target functions; Drug target motif

Community Interest

1C21

59.4%

Francisella tularensis

N/A

IDP02365
(show subtarget assignments)

1

purified

No

FTT0403

56707552

def1

peptide deformylase [Francisella tularen...

211

Conserved; Drug target functions

Phase 3: June 2008

3M6O

28.4%

Francisella tularensis

Protein fate

Protein modification and repair

IDP02684
(show subtarget assignments)

1

cloned

No

FTT0405

56707554

lolD

lipoprotein releasing system, subunit D,...

231

Conserved; Drug target functions

Phase 3: June 2008

1F3O

44.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01830
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0407

56707556

gcvT

glycine cleavage system aminomethyltrans...

358

Drug Target

Phase 3: June 2008

1VLO

47.9%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02185
(show subtarget assignments)

1

selected

No

FTT0408

56707557

gcvH

glycine cleavage system H protein [Franc...

127

Drug Target

Phase 3: June 2008

3A7A

59.8%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02183
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0414

56707563

pgm

phosphoglucomutase [Francisella tularens...

544

Drug Target

Phase 3: June 2008

1C47

54.4%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02368
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0422

56707569

murF

UDP-N--acetylmuramoylalanyl-D-glutamyl-2...

452

Conserved; Drug target functions

Phase 3: June 2008

1GG4

33.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02783
(show subtarget assignments)

1

expressed

No

FTT0425c

56707572

asd

aspartate-semialdehyde dehydrogenase [Fr...

364

Conserved; Drug target functions

Phase 3: June 2008

1NWC

50%

Francisella tularensis

Amino acid biosynthesis

Aspartate family

IDP02311
(show subtarget assignments)

1

in_pdb
3MJD

Yes

FTT0437c

56707581

pyrE

orotate phosphoribosyltransferase [Franc...

208

Drug Target

Phase 3: June 2008

3MJD

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02373
(show subtarget assignments)

1

expressed

No

FTT0438

56707582

mpl

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

456

Conserved; Drug target functions

Phase 3: June 2008

3HN7

41.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02376
(show subtarget assignments)

1

cloned

No

FTT0451

56707593

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

416

Conserved; Drug target functions

Phase 3: June 2008

1E0D

31.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04026
(show subtarget assignments)

1

expressed

No

FTT0456c

56707598

hypothetical protein FTT_0456c [Francise...

97

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YHD

39.2%

Francisella tularensis

IDP91217
(show subtarget assignments)

1

expressed

No

FTT_0458

56707600

sspA

stringent starvation protein A, regulato...

210

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LYK

31.4%

Francisella tularensis

IDP91058
(show subtarget assignments)

8

soluble

No

FTT_0468

56707610

surA

peptidyl-prolyl cis-trans isomerase (PPI...

473

virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...

Community Requests

1M5Y

19.5%

Francisella tularensis

Targets