Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01927 (show subtarget assignments)	1	expressed	No	CBU_1787	29542344	glmS	glucosamine--fructose-6-phosphate aminot...	611	Conserved; Drug target functions	Phase 3: June 2008	1JXA	58.3%	Coxiella burnetii	Central intermediary metabolism	Amino sugars

IDP01921 (show subtarget assignments)	1	expressed	No	CBU_1154	29541726	trpC	indole-3-glycerol phosphate synthase [Co...	257	Conserved; Drug target functions	Phase 3: June 2008	3QJA	37%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01920 (show subtarget assignments)	1	expressed	No	CBU_1156	29541728	trpA	tryptophan synthase, alpha subunit [Coxi...	267	Conserved; Drug target functions	Phase 3: June 2008	1V7Y	35.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01910 (show subtarget assignments)	1	expressed	No	CBU_0798	29541392		multidrug resistance protein [Coxiella b...	331	Conserved; Drug target functions	Phase 3: June 2008	3FPP	19.3%	Coxiella burnetii	Transport and binding proteins	Other

IDP02646 (show subtarget assignments)	1	expressed	No	CBU_1290	29541858	dnaK	chaperone protein dnak [Coxiella burneti...	656	Conserved; Drug target functions	Phase 3: June 2008	2KHO	68.9%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP91097 (show subtarget assignments)	0	work_stopped	No	CBU_0479	29541085	kdsB	3-deoxy-D-manno-octulosonate cytidylyltr...	253	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	3TQD	100%	Coxiella burnetii

IDP02629 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01858 (show subtarget assignments)	1	cloned	No	CBU_0993	29541575	def	peptide deformylase [Coxiella burnetii R...	170	Conserved; Drug target functions	Phase 3: June 2008	1N5N	47.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01853 (show subtarget assignments)	1	cloned	No	CBU_1669	29542228	rpoS	RNA polymerase sigma factor RpoS [Coxiel...	352	Conserved; Drug target functions	Phase 3: June 2008	3IYD	31.5%	Coxiella burnetii	Transcription	Transcription factors

IDP02622 (show subtarget assignments)	1	cloned	No	CBU_0109	29540729		ABC transporter, periplasmic substrate-b...	267	Conserved; Drug target functions	Phase 3: June 2008	3TQW	88.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01846 (show subtarget assignments)	1	soluble	No	CBU_1419	29541979		serine hydroxymethyltransferase [Coxiell...	419	Conserved; Drug target functions	Phase 3: June 2008	1DFO	68.5%	Coxiella burnetii	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01842 (show subtarget assignments)	1	in_pdb 3SLH 4EGR 3ROI	Yes	CBU_0526	29541129	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	438	Conserved; Drug target functions	Phase 3: June 2008	3ROI	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01835 (show subtarget assignments)	1	cloned	No	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02607 (show subtarget assignments)	1	expressed	No	CBU_0101	29540723	nadB	L-aspartate oxidase [Coxiella burnetii R...	536	Conserved; Drug target functions	Phase 3: June 2008	1CHU	52.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02608 (show subtarget assignments)	1	expressed	No	CBU_0178	29540794		ABC transporter, ATP-binding protein [Co...	252	Conserved; Drug target functions	Phase 3: June 2008	1V43	43.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02604 (show subtarget assignments)	1	expressed	No	CBU_1893	29542450	aroB	3-dehydroquinate synthase [Coxiella burn...	360	Conserved; Drug target functions	Phase 3: June 2008	3OKF	48.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01815 (show subtarget assignments)	1	soluble	No	CBU_1382	29541947	uppS	undecaprenyl diphosphate synthase [Coxie...	237	Conserved; Drug target functions	Phase 3: June 2008	1JP3	49.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01805 (show subtarget assignments)	1	soluble	No	CBU_1084	29541658		sensory box sensor histidine kinase/resp...	683	Conserved; Drug target functions	Phase 3: June 2008	2C2A	12.4%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01803 (show subtarget assignments)	1	soluble	No	CBU_0646	29541247	ribE	riboflavin synthase, alpha subunit [Coxi...	202	Conserved; Drug target functions	Phase 3: June 2008	1I8D	37.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01797 (show subtarget assignments)	1	cloned	No	CBU_1008	29541590	bioA	adenosylmethionine-8-amino-7-oxononanoat...	442	Conserved; Drug target functions	Phase 3: June 2008	3DOD	35.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01786 (show subtarget assignments)	1	expressed	No	CBU_0502	29541107		hydrolase, putative [Coxiella burnetii R...	225	Conserved; Drug target functions	Phase 3: June 2008	2GZX	44.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP01785 (show subtarget assignments)	1	expressed	No	CBU_0667	29541271	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxy...	271	Conserved; Drug target functions	Phase 3: June 2008	1KGQ	62.7%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01779 (show subtarget assignments)	1	soluble	No	CBU_0366	29540977	phoR	sensor histidine kinase PhoR protein, pu...	252	Conserved; Drug target functions	Phase 3: June 2008	2C2A	31.3%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01777 (show subtarget assignments)	1	cloned	No	CBU_0313	29540926		transglycosylase, Slt family [Coxiella b...	487	Conserved; Drug target functions	Phase 3: June 2008	1QSA	9.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91602 (show subtarget assignments)	8	expressed	No	CBU_2056	29542607		hypothetical protein	219	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01758 (show subtarget assignments)	1	expressed	No	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01754 (show subtarget assignments)	1	expressed	No	CBU_0803	29541397		efflux transporter, RND family, MFP subu...	351	Conserved; Drug target functions	Phase 3: June 2008	1T5E	27.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP01753 (show subtarget assignments)	1	expressed	No	CBU_0423	29541032	panC	pantoate--beta-alanine ligase [Coxiella ...	257	Conserved; Drug target functions	Phase 3: June 2008	3N8H	40.9%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02565 (show subtarget assignments)	1	soluble	No	CBU_0648	29541249	ribH	6,7-dimethyl-8-ribityllumazine synthase ...	151	Conserved; Drug target functions	Phase 3: June 2008	1VSW	47.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01743 (show subtarget assignments)	1	purified	No	CBU_1350	29541915	glmM	phosphoglucosamine mutase [Coxiella burn...	446	Conserved; Drug target functions	Phase 3: June 2008	3PDK	44.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01735 (show subtarget assignments)	1	soluble	No	CBU_1129	29541703	nifS	cysteine desulfurase [Coxiella burnetii ...	396	Conserved; Drug target functions	Phase 3: June 2008	1P3W	57.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01734 (show subtarget assignments)	1	cloned	No	CBU_1094	29541668		efflux transporter, RND family, MFP subu...	380	Conserved; Drug target functions	Phase 3: June 2008	3FPP	23.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP01731 (show subtarget assignments)	1	expressed	No	CBU_1222	29541792	dapA	dihydrodipicolinate synthase [Coxiella b...	289	Conserved; Drug target functions	Phase 3: June 2008	3QZE	55.2%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01728 (show subtarget assignments)	1	expressed	No	CBU_0840	29541434	asnB-2	asparagine synthetase B, glutamine-hydro...	637	Conserved; Drug target functions	Phase 3: June 2008	1Q15	13%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02555 (show subtarget assignments)	1	expressed	No	CBU_0391	29541001	ribF	riboflavin biosynthesis protein RibF [Co...	320	Conserved; Drug target functions	Phase 3: June 2008	1MRZ	33.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01701 (show subtarget assignments)	1	soluble	No	CBU_1970	29542525	dapF	diaminopimelate epimerase [Coxiella burn...	276	Conserved; Drug target functions	Phase 3: June 2008	1GQZ	48.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01700 (show subtarget assignments)	1	expressed	No	CBU_1899	29542456		methyltransferase, putative [Coxiella bu...	193	Conserved; Drug target functions	Phase 3: June 2008	2FPO	51%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP02552 (show subtarget assignments)	1	expressed	No	CBU_0743	29541343	ptsH	phosphocarrier protein HPr [Coxiella bur...	89	Conserved; Drug target functions	Phase 3: June 2008	3LE1	46.1%	Coxiella burnetii	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02540 (show subtarget assignments)	1	cloned	No	CBU_1584	29542144	shaE	monovalent cation/proton antiporter subu...	115	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP02541 (show subtarget assignments)	1	expressed	No	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01691 (show subtarget assignments)	1	cloned	No	CBU_1575	29542135	tolR	tolR protein [Coxiella burnetii RSA 493]...	147	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Other

IDP01690 (show subtarget assignments)	1	soluble	No	CBU_1719	29542277	groES	chaperonin, 10 kDa [Coxiella burnetii RS...	96	Conserved; Drug target functions	Phase 3: June 2008	3NX6	58.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP01689 (show subtarget assignments)	1	soluble	No	CBU_1708	29542266	sodB	superoxide dismutase (fe) [Coxiella burn...	193	Conserved; Drug target functions	Phase 3: June 2008	3TQJ	100%	Coxiella burnetii	Cellular processes	Detoxification

IDP02543 (show subtarget assignments)	1	expressed	No	CBU_0275	29540889	hemE	uroporphyrinogen decarboxylase [Coxiella...	361	Conserved; Drug target functions	Phase 3: June 2008	3CYV	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01676 (show subtarget assignments)	1	cloned	No	CBU_0869	29541462	alr	alanine racemase [Coxiella burnetii RSA ...	364	Conserved; Drug target functions	Phase 3: June 2008	2RJG	42.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02522 (show subtarget assignments)	1	expressed	No	CBU_1966	29542521	hemA	glutamyl-tRNA reductase [Coxiella burnet...	413	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	30.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01660 (show subtarget assignments)	1	expressed	No	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01659 (show subtarget assignments)	1	crystallized	No	CBU_1739	29542296		tetrapyrrole (Corrin/Porphyrin) methylas...	285	Conserved; Drug target functions	Phase 3: June 2008	3KWP	42.1%	Coxiella burnetii	Unknown function	General

IDP01649 (show subtarget assignments)	1	expressed	No	CBU_0796	29541390		HIT family protein [Coxiella burnetii RS...	113	Conserved; Drug target functions	Phase 3: June 2008	1AV5	49.6%	Coxiella burnetii	Unknown function	General

IDP01647 (show subtarget assignments)	1	expressed	No	CBU_0795	29541389	folE	GTP cyclohydrolase I [Coxiella burnetii ...	184	Conserved; Drug target functions	Phase 3: June 2008	1WM9	56%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02514 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0116	29540736	mraW	S-adenosyl-methyltransferase MraW [Coxie...	307	Conserved; Drug target functions	Phase 3: June 2008	1WG8	46.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP02511 (show subtarget assignments)	1	soluble	No	CBU_1359	29541924	sufC	ABC transporter, ATP-binding protein [Co...	244	Conserved; Drug target functions	Phase 3: June 2008	2D3W	63.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01641 (show subtarget assignments)	1	cloned	No	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	Phase 3: June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01638 (show subtarget assignments)	1	soluble	No	CBU_0312	29540925	folD	folD bifunctional protein [Coxiella burn...	283	Conserved; Drug target functions	Phase 3: June 2008	1B0A	59.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01631 (show subtarget assignments)	1	soluble	No	CBU_2024	29542577		cystathionine beta-synthase, putative [C...	316	Conserved; Drug target functions	Phase 3: June 2008	1JBQ	60.9%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP01630 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1964	29542519	hemK	protein methyltransferase HemK [Coxiella...	277	Conserved; Drug target functions	Phase 3: June 2008	1T43	42.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01629 (show subtarget assignments)	1	cloned	No	CBU_1903	29542460	ftsY	signal recognition particle-docking prot...	324	Conserved; Drug target functions	Phase 3: June 2008	2YHS	58%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01628 (show subtarget assignments)	1	cloned	No	CBU_1909	29542466	rpoH	RNA polymerase sigma-32 factor [Coxiella...	288	Conserved; Drug target functions	Phase 3: June 2008	3IYD	26.4%	Coxiella burnetii	Protein synthesis	Translation factors

IDP01624 (show subtarget assignments)	1	expressed	No	CBU_1879	29542436		polypeptide deformylase, putative [Coxie...	209	Conserved; Drug target functions	Phase 3: June 2008	1LM6	29.2%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01619 (show subtarget assignments)	1	expressed	No	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	Phase 3: June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01615 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0643	29541244	ribD	riboflavin biosynthesis protein RibD [Co...	354	Conserved; Drug target functions	Phase 3: June 2008	2HXV	35.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04733 (show subtarget assignments)	1	cloned	No	CBU_0789	215919045		two component system histidine kinase [C...	831	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.5%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01608 (show subtarget assignments)	1	cloned	No	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	Phase 3: June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01604 (show subtarget assignments)	1	crystallized	No	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	3QF4	25.6%	Coxiella burnetii	Transport and binding proteins	Other

IDP01601 (show subtarget assignments)	1	expressed	No	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04341 (show subtarget assignments)	1	expressed	No	CBU_0634	215919011		putative aerobic respiration control sen...	630	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	14.8%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP02482 (show subtarget assignments)	1	expressed	No	CBU_1857	29542411	oppD	peptide ABC transporter, ATP-binding pro...	530	Conserved; Drug target functions	Phase 3: June 2008	3PIH	24.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP02483 (show subtarget assignments)	1	cloned	No	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04632 (show subtarget assignments)	1	cloned	No	CBU_2005	29655288	rstB	signal transduction histidine kinase-lik...	425	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.2%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP04629 (show subtarget assignments)	1	soluble	No	CBU_0151	29653509	queF	7-cyano-7-deazaguanine reductase [Coxiel...	278	drug target; conserved gene;	Phase 4: April 2009	3BP1	51.4%	Coxiella burnetii	Hypothetical proteins	Conserved

IDP04631 (show subtarget assignments)	1	cloned	No	CBU_1891	215919282	pilQ	type II and III secretion system family ...	353	conserved gene;	Phase 4: April 2009			Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP04630 (show subtarget assignments)	1	cloned	No	CBU_1228	29654531	qseC	sensor protein qseC [Coxiella burnetii R...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	19%	Coxiella burnetii	Regulatory functions	Other

IDP04031 (show subtarget assignments)	1	cloned	No	CBU_A0011	29648123		hypothetical protein CBUA0011 [Coxiella ...	56	drug target;	Phase 4: April 2009			Coxiella burnetii	Hypothetical proteins	Domain

IDP00320 (show subtarget assignments)	1	expressed	No	CBU_0550	29653890	pbpA	penicillin-binding protein 2	612	Drug Target Function	Phase 2: March 2008	1MWR	25.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00319 (show subtarget assignments)	1	expressed	No	CBU_2070	29655348		chorismate mutase, putative	136	Drug Target Function	Phase 2: March 2008			Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00318 (show subtarget assignments)	1	cloned	No	CBU_1947	29655231	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Drug Target Function	Phase 2: March 2008	1HV9	51.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00317 (show subtarget assignments)	1	cloned	No	CBU_1887	29655172	ponA	penicillin-binding protein 1A	793	Drug Target Function	Phase 2: March 2008	3UDF	40.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00316 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00315 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0874	29654200	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1R52	44.7%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP91584 (show subtarget assignments)	8	expressed	No	CBU_0425	29541034		hypothetical protein	455	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91583 (show subtarget assignments)	8	expressed	No	CBU_0329	29540941		hypothetical protein	198	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91582 (show subtarget assignments)	8	cloned	No	CBU_0295	29540908		hypothetical protein	489	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91581 (show subtarget assignments)	8	cloned	No	CBU_0080	29540703		hypothetical protein	160	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91580 (show subtarget assignments)	8	cloned	No	CBU_0077	29540700		hypothetical protein	263	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP00314 (show subtarget assignments)	1	expressed	No	CBU_0751	29654085	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Function	Phase 2: March 2008	1EJC	57.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02426 (show subtarget assignments)	1	cloned	No	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00309 (show subtarget assignments)	1	expressed	No	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02390 (show subtarget assignments)	1	cloned	No	CBU_1718	29542276	groEL	chaperonin, 60 kDa [Coxiella burnetii RS...	552	Conserved; Drug target functions	Phase 3: June 2008	2EU1	75.5%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP00308 (show subtarget assignments)	1	soluble	No	CBU_0288	29653640	coaD	phosphopantetheine adenylyltransferase	159	Drug Target Function	Phase 2: March 2008	3IKZ	47.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00307 (show subtarget assignments)	1	expressed	No	CBU_0142	29653500	lpxC	UDP-3-0-acyl N-acetylglucosamine deacety...	303	Drug Target Function	Phase 2: March 2008	2VES	65.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02378 (show subtarget assignments)	1	cloned	No	CBU_1675	29542234	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	280	Conserved; Drug target functions	Phase 3: June 2008	3T4C	62.5%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00306 (show subtarget assignments)	1	expressed	No	CBU_0137	29653495	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	316	Drug Target Function	Phase 2: March 2008	3TX1	34.8%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02371 (show subtarget assignments)	1	expressed	No	CBU_1904	29542461	ftsE	cell division ABC transporter, ATP-bindi...	217	Conserved; Drug target functions	Phase 3: June 2008	1F3O	38.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00305 (show subtarget assignments)	1	cloned	No	CBU_0118	29653476	pbpB	penicillin-binding protein 3	548	Drug Target Function	Phase 2: March 2008	3OC2	45.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02361 (show subtarget assignments)	1	expressed	No	CBU_1550	29542109	ptsP	phosphoenolpyruvate-protein phosphotrans...	759	Conserved; Drug target functions	Phase 3: June 2008	2HRO	28.3%	Coxiella burnetii	Signal transduction	PTS

IDP00304 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0038	29653401		3-oxoacyl-(acyl-carrier-protein) synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	29.6%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00303 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0035	29653398		beta-ketoacyl synthase	424	Drug Target Function	Phase 2: March 2008	3E60	36.8%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00302 (show subtarget assignments)	1	expressed	No	CBU_1155	29654460	trpBF	N-(5'phosphoribosyl)anthranilate isomera...	600	Drug Target Function	Phase 2: March 2008	1V8Z	38%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00301 (show subtarget assignments)	1	expressed	No	CBU_0983				291	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 2: March 2008	3NVT	10.7%	Coxiella burnetii

IDP01927
(show subtarget assignments)

1

expressed

No

CBU_1787

29542344

glmS

glucosamine--fructose-6-phosphate aminot...

611

Conserved; Drug target functions

Phase 3: June 2008

1JXA

58.3%

Coxiella burnetii

Central intermediary metabolism

Amino sugars

IDP01921
(show subtarget assignments)

1

expressed

No

CBU_1154

29541726

trpC

indole-3-glycerol phosphate synthase [Co...

257

Conserved; Drug target functions

Phase 3: June 2008

3QJA

37%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01920
(show subtarget assignments)

1

expressed

No

CBU_1156

29541728

trpA

tryptophan synthase, alpha subunit [Coxi...

267

Conserved; Drug target functions

Phase 3: June 2008

1V7Y

35.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01910
(show subtarget assignments)

1

expressed

No

CBU_0798

29541392

multidrug resistance protein [Coxiella b...

331

Conserved; Drug target functions

Phase 3: June 2008

3FPP

19.3%

Coxiella burnetii

Transport and binding proteins

Other

IDP02646
(show subtarget assignments)

1

expressed

No

CBU_1290

29541858

dnaK

chaperone protein dnak [Coxiella burneti...

656

Conserved; Drug target functions

Phase 3: June 2008

2KHO

68.9%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP91097
(show subtarget assignments)

0

work_stopped

No

CBU_0479

29541085

kdsB

3-deoxy-D-manno-octulosonate cytidylyltr...

253

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

3TQD

100%

Coxiella burnetii

IDP02629
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01858
(show subtarget assignments)

1

cloned

No

CBU_0993

29541575

def

peptide deformylase [Coxiella burnetii R...

170

Conserved; Drug target functions

Phase 3: June 2008

1N5N

47.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01853
(show subtarget assignments)

1

cloned

No

CBU_1669

29542228

rpoS

RNA polymerase sigma factor RpoS [Coxiel...

352

Conserved; Drug target functions

Phase 3: June 2008

3IYD

31.5%

Coxiella burnetii

Transcription

Transcription factors

IDP02622
(show subtarget assignments)

1

cloned

No

CBU_0109

29540729

ABC transporter, periplasmic substrate-b...

267

Conserved; Drug target functions

Phase 3: June 2008

3TQW

88.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01846
(show subtarget assignments)

1

soluble

No

CBU_1419

29541979

serine hydroxymethyltransferase [Coxiell...

419

Conserved; Drug target functions

Phase 3: June 2008

1DFO

68.5%

Coxiella burnetii

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01842
(show subtarget assignments)

1

in_pdb
3SLH
4EGR
3ROI

Yes

CBU_0526

29541129

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

438

Conserved; Drug target functions

Phase 3: June 2008

3ROI

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01835
(show subtarget assignments)

1

cloned

No

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02607
(show subtarget assignments)

1

expressed

No

CBU_0101

29540723

nadB

L-aspartate oxidase [Coxiella burnetii R...

536

Conserved; Drug target functions

Phase 3: June 2008

1CHU

52.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02608
(show subtarget assignments)

1

expressed

No

CBU_0178

29540794

ABC transporter, ATP-binding protein [Co...

252

Conserved; Drug target functions

Phase 3: June 2008

1V43

43.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02604
(show subtarget assignments)

1

expressed

No

CBU_1893

29542450

aroB

3-dehydroquinate synthase [Coxiella burn...

360

Conserved; Drug target functions

Phase 3: June 2008

3OKF

48.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01815
(show subtarget assignments)

1

soluble

No

CBU_1382

29541947

uppS

undecaprenyl diphosphate synthase [Coxie...

237

Conserved; Drug target functions

Phase 3: June 2008

1JP3

49.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01805
(show subtarget assignments)

1

soluble

No

CBU_1084

29541658

sensory box sensor histidine kinase/resp...

683

Conserved; Drug target functions

Phase 3: June 2008

2C2A

12.4%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01803
(show subtarget assignments)

1

soluble

No

CBU_0646

29541247

ribE

riboflavin synthase, alpha subunit [Coxi...

202

Conserved; Drug target functions

Phase 3: June 2008

1I8D

37.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01797
(show subtarget assignments)

1

cloned

No

CBU_1008

29541590

bioA

adenosylmethionine-8-amino-7-oxononanoat...

442

Conserved; Drug target functions

Phase 3: June 2008

3DOD

35.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01786
(show subtarget assignments)

1

expressed

No

CBU_0502

29541107

hydrolase, putative [Coxiella burnetii R...

225

Conserved; Drug target functions

Phase 3: June 2008

2GZX

44.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP01785
(show subtarget assignments)

1

expressed

No

CBU_0667

29541271

dapD

2,3,4,5-tetrahydropyridine-2,6-dicarboxy...

271

Conserved; Drug target functions

Phase 3: June 2008

1KGQ

62.7%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01779
(show subtarget assignments)

1

soluble

No

CBU_0366

29540977

phoR

sensor histidine kinase PhoR protein, pu...

252

Conserved; Drug target functions

Phase 3: June 2008

2C2A

31.3%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01777
(show subtarget assignments)

1

cloned

No

CBU_0313

29540926

transglycosylase, Slt family [Coxiella b...

487

Conserved; Drug target functions

Phase 3: June 2008

1QSA

9.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91602
(show subtarget assignments)

8

expressed

No

CBU_2056

29542607

hypothetical protein

219

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01758
(show subtarget assignments)

1

expressed

No

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01754
(show subtarget assignments)

1

expressed

No

CBU_0803

29541397

efflux transporter, RND family, MFP subu...

351

Conserved; Drug target functions

Phase 3: June 2008

1T5E

27.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP01753
(show subtarget assignments)

1

expressed

No

CBU_0423

29541032

panC

pantoate--beta-alanine ligase [Coxiella ...

257

Conserved; Drug target functions

Phase 3: June 2008

3N8H

40.9%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02565
(show subtarget assignments)

1

soluble

No

CBU_0648

29541249

ribH

6,7-dimethyl-8-ribityllumazine synthase ...

151

Conserved; Drug target functions

Phase 3: June 2008

1VSW

47.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01743
(show subtarget assignments)

1

purified

No

CBU_1350

29541915

glmM

phosphoglucosamine mutase [Coxiella burn...

446

Conserved; Drug target functions

Phase 3: June 2008

3PDK

44.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01735
(show subtarget assignments)

1

soluble

No

CBU_1129

29541703

nifS

cysteine desulfurase [Coxiella burnetii ...

396

Conserved; Drug target functions

Phase 3: June 2008

1P3W

57.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01734
(show subtarget assignments)

1

cloned

No

CBU_1094

29541668

efflux transporter, RND family, MFP subu...

380

Conserved; Drug target functions

Phase 3: June 2008

3FPP

23.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP01731
(show subtarget assignments)

1

expressed

No

CBU_1222

29541792

dapA

dihydrodipicolinate synthase [Coxiella b...

289

Conserved; Drug target functions

Phase 3: June 2008

3QZE

55.2%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01728
(show subtarget assignments)

1

expressed

No

CBU_0840

29541434

asnB-2

asparagine synthetase B, glutamine-hydro...

637

Conserved; Drug target functions

Phase 3: June 2008

1Q15

13%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02555
(show subtarget assignments)

1

expressed

No

CBU_0391

29541001

ribF

riboflavin biosynthesis protein RibF [Co...

320

Conserved; Drug target functions

Phase 3: June 2008

1MRZ

33.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01701
(show subtarget assignments)

1

soluble

No

CBU_1970

29542525

dapF

diaminopimelate epimerase [Coxiella burn...

276

Conserved; Drug target functions

Phase 3: June 2008

1GQZ

48.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01700
(show subtarget assignments)

1

expressed

No

CBU_1899

29542456

methyltransferase, putative [Coxiella bu...

193

Conserved; Drug target functions

Phase 3: June 2008

2FPO

51%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP02552
(show subtarget assignments)

1

expressed

No

CBU_0743

29541343

ptsH

phosphocarrier protein HPr [Coxiella bur...

89

Conserved; Drug target functions

Phase 3: June 2008

3LE1

46.1%

Coxiella burnetii

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02540
(show subtarget assignments)

1

cloned

No

CBU_1584

29542144

shaE

monovalent cation/proton antiporter subu...

115

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP02541
(show subtarget assignments)

1

expressed

No

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01691
(show subtarget assignments)

1

cloned

No

CBU_1575

29542135

tolR

tolR protein [Coxiella burnetii RSA 493]...

147

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Other

IDP01690
(show subtarget assignments)

1

soluble

No

CBU_1719

29542277

groES

chaperonin, 10 kDa [Coxiella burnetii RS...

96

Conserved; Drug target functions

Phase 3: June 2008

3NX6

58.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP01689
(show subtarget assignments)

1

soluble

No

CBU_1708

29542266

sodB

superoxide dismutase (fe) [Coxiella burn...

193

Conserved; Drug target functions

Phase 3: June 2008

3TQJ

100%

Coxiella burnetii

Cellular processes

Detoxification

IDP02543
(show subtarget assignments)

1

expressed

No

CBU_0275

29540889

hemE

uroporphyrinogen decarboxylase [Coxiella...

361

Conserved; Drug target functions

Phase 3: June 2008

3CYV

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01676
(show subtarget assignments)

1

cloned

No

CBU_0869

29541462

alr

alanine racemase [Coxiella burnetii RSA ...

364

Conserved; Drug target functions

Phase 3: June 2008

2RJG

42.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02522
(show subtarget assignments)

1

expressed

No

CBU_1966

29542521

hemA

glutamyl-tRNA reductase [Coxiella burnet...

413

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

30.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01660
(show subtarget assignments)

1

expressed

No

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01659
(show subtarget assignments)

1

crystallized

No

CBU_1739

29542296

tetrapyrrole (Corrin/Porphyrin) methylas...

285

Conserved; Drug target functions

Phase 3: June 2008

3KWP

42.1%

Coxiella burnetii

Unknown function

General

IDP01649
(show subtarget assignments)

1

expressed

No

CBU_0796

29541390

HIT family protein [Coxiella burnetii RS...

113

Conserved; Drug target functions

Phase 3: June 2008

1AV5

49.6%

Coxiella burnetii

Unknown function

General

IDP01647
(show subtarget assignments)

1

expressed

No

CBU_0795

29541389

folE

GTP cyclohydrolase I [Coxiella burnetii ...

184

Conserved; Drug target functions

Phase 3: June 2008

1WM9

56%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02514
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0116

29540736

mraW

S-adenosyl-methyltransferase MraW [Coxie...

307

Conserved; Drug target functions

Phase 3: June 2008

1WG8

46.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP02511
(show subtarget assignments)

1

soluble

No

CBU_1359

29541924

sufC

ABC transporter, ATP-binding protein [Co...

244

Conserved; Drug target functions

Phase 3: June 2008

2D3W

63.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01641
(show subtarget assignments)

1

cloned

No

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

Phase 3: June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01638
(show subtarget assignments)

1

soluble

No

CBU_0312

29540925

folD

folD bifunctional protein [Coxiella burn...

283

Conserved; Drug target functions

Phase 3: June 2008

1B0A

59.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01631
(show subtarget assignments)

1

soluble

No

CBU_2024

29542577

cystathionine beta-synthase, putative [C...

316

Conserved; Drug target functions

Phase 3: June 2008

1JBQ

60.9%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP01630
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1964

29542519

hemK

protein methyltransferase HemK [Coxiella...

277

Conserved; Drug target functions

Phase 3: June 2008

1T43

42.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01629
(show subtarget assignments)

1

cloned

No

CBU_1903

29542460

ftsY

signal recognition particle-docking prot...

324

Conserved; Drug target functions

Phase 3: June 2008

2YHS

58%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01628
(show subtarget assignments)

1

cloned

No

CBU_1909

29542466

rpoH

RNA polymerase sigma-32 factor [Coxiella...

288

Conserved; Drug target functions

Phase 3: June 2008

3IYD

26.4%

Coxiella burnetii

Protein synthesis

Translation factors

IDP01624
(show subtarget assignments)

1

expressed

No

CBU_1879

29542436

polypeptide deformylase, putative [Coxie...

209

Conserved; Drug target functions

Phase 3: June 2008

1LM6

29.2%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01619
(show subtarget assignments)

1

expressed

No

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

Phase 3: June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01615
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0643

29541244

ribD

riboflavin biosynthesis protein RibD [Co...

354

Conserved; Drug target functions

Phase 3: June 2008

2HXV

35.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04733
(show subtarget assignments)

1

cloned

No

CBU_0789

215919045

two component system histidine kinase [C...

831

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.5%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01608
(show subtarget assignments)

1

cloned

No

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

Phase 3: June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01604
(show subtarget assignments)

1

crystallized

No

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

3QF4

25.6%

Coxiella burnetii

Transport and binding proteins

Other

IDP01601
(show subtarget assignments)

1

expressed

No

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04341
(show subtarget assignments)

1

expressed

No

CBU_0634

215919011

putative aerobic respiration control sen...

630

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

14.8%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP02482
(show subtarget assignments)

1

expressed

No

CBU_1857

29542411

oppD

peptide ABC transporter, ATP-binding pro...

530

Conserved; Drug target functions

Phase 3: June 2008

3PIH

24.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP02483
(show subtarget assignments)

1

cloned

No

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04632
(show subtarget assignments)

1

cloned

No

CBU_2005

29655288

rstB

signal transduction histidine kinase-lik...

425

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.2%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP04629
(show subtarget assignments)

1

soluble

No

CBU_0151

29653509

queF

7-cyano-7-deazaguanine reductase [Coxiel...

278

drug target; conserved gene;

Phase 4: April 2009

3BP1

51.4%

Coxiella burnetii

Hypothetical proteins

Conserved

IDP04631
(show subtarget assignments)

1

cloned

No

CBU_1891

215919282

pilQ

type II and III secretion system family ...

353

conserved gene;

Phase 4: April 2009

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP04630
(show subtarget assignments)

1

cloned

No

CBU_1228

29654531

qseC

sensor protein qseC [Coxiella burnetii R...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

19%

Coxiella burnetii

Regulatory functions

Other

IDP04031
(show subtarget assignments)

1

cloned

No

CBU_A0011

29648123

hypothetical protein CBUA0011 [Coxiella ...

56

drug target;

Phase 4: April 2009

Coxiella burnetii

Hypothetical proteins

Domain

IDP00320
(show subtarget assignments)

1

expressed

No

CBU_0550

29653890

pbpA

penicillin-binding protein 2

612

Drug Target Function

Phase 2: March 2008

1MWR

25.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00319
(show subtarget assignments)

1

expressed

No

CBU_2070

29655348

chorismate mutase, putative

136

Drug Target Function

Phase 2: March 2008

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00318
(show subtarget assignments)

1

cloned

No

CBU_1947

29655231

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Drug Target Function

Phase 2: March 2008

1HV9

51.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00317
(show subtarget assignments)

1

cloned

No

CBU_1887

29655172

ponA

penicillin-binding protein 1A

793

Drug Target Function

Phase 2: March 2008

3UDF

40.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00316
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00315
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0874

29654200

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1R52

44.7%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP91584
(show subtarget assignments)

8

expressed

No

CBU_0425

29541034

hypothetical protein

455

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91583
(show subtarget assignments)

8

expressed

No

CBU_0329

29540941

hypothetical protein

198

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91582
(show subtarget assignments)

8

cloned

No

CBU_0295

29540908

hypothetical protein

489

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91581
(show subtarget assignments)

8

cloned

No

CBU_0080

29540703

hypothetical protein

160

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91580
(show subtarget assignments)

8

cloned

No

CBU_0077

29540700

hypothetical protein

263

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP00314
(show subtarget assignments)

1

expressed

No

CBU_0751

29654085

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Function

Phase 2: March 2008

1EJC

57.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02426
(show subtarget assignments)

1

cloned

No

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00309
(show subtarget assignments)

1

expressed

No

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02390
(show subtarget assignments)

1

cloned

No

CBU_1718

29542276

groEL

chaperonin, 60 kDa [Coxiella burnetii RS...

552

Conserved; Drug target functions

Phase 3: June 2008

2EU1

75.5%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP00308
(show subtarget assignments)

1

soluble

No

CBU_0288

29653640

coaD

phosphopantetheine adenylyltransferase

159

Drug Target Function

Phase 2: March 2008

3IKZ

47.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00307
(show subtarget assignments)

1

expressed

No

CBU_0142

29653500

lpxC

UDP-3-0-acyl N-acetylglucosamine deacety...

303

Drug Target Function

Phase 2: March 2008

2VES

65.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02378
(show subtarget assignments)

1

cloned

No

CBU_1675

29542234

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

280

Conserved; Drug target functions

Phase 3: June 2008

3T4C

62.5%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00306
(show subtarget assignments)

1

expressed

No

CBU_0137

29653495

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

316

Drug Target Function

Phase 2: March 2008

3TX1

34.8%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02371
(show subtarget assignments)

1

expressed

No

CBU_1904

29542461

ftsE

cell division ABC transporter, ATP-bindi...

217

Conserved; Drug target functions

Phase 3: June 2008

1F3O

38.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00305
(show subtarget assignments)

1

cloned

No

CBU_0118

29653476

pbpB

penicillin-binding protein 3

548

Drug Target Function

Phase 2: March 2008

3OC2

45.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02361
(show subtarget assignments)

1

expressed

No

CBU_1550

29542109

ptsP

phosphoenolpyruvate-protein phosphotrans...

759

Conserved; Drug target functions

Phase 3: June 2008

2HRO

28.3%

Coxiella burnetii

Signal transduction

PTS

IDP00304
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0038

29653401

3-oxoacyl-(acyl-carrier-protein) synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

29.6%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00303
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0035

29653398

beta-ketoacyl synthase

424

Drug Target Function

Phase 2: March 2008

3E60

36.8%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00302
(show subtarget assignments)

1

expressed

No

CBU_1155

29654460

trpBF

N-(5'phosphoribosyl)anthranilate isomera...

600

Drug Target Function

Phase 2: March 2008

1V8Z

38%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00301
(show subtarget assignments)

1

expressed

No

CBU_0983

291

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 2: March 2008

3NVT

10.7%

Coxiella burnetii

Targets