Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05265 (show subtarget assignments)	1	purified	No	CD3543	126701167		putative nicotinate phosphribosyltransfe...	476	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2F7F	43.3%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04595 (show subtarget assignments)	1	soluble	No	BAS0565	49183590		nicotinate phosphoribosyltransferase [Ba...	487	Proposed to be essential proteins	Phase 4: April 2009	2F7F	61.4%	Bacillus anthracis

IDP02419 (show subtarget assignments)	1	purified	No	FTT1447c	56708489	manB	phosphomannomutase [Francisella tularens...	494	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2F7L	25.7%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP90249 (show subtarget assignments)	8	soluble	No	VC2645	15642640		acetylornithine deacetylase [Vibrio chol...	378	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2F7V	26.8%	Vibrio cholerae

IDP90251 (show subtarget assignments)	8	expressed	No	SF4034	56480493	argE	acetylornithine deacetylase [Shigella fl...	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2F7V	25.1%	Shigella flexneri

IDP92040 (show subtarget assignments)	8	selected	No	TGME49_039310	237834547		ribose 5-phosphate isomerase, putative [...	259	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F8M	42.5%	Toxoplasma gondii

IDP00753 (show subtarget assignments)	1	cloned	No	SACOL0052	57286607		glycosyl transferase, group 1 family pro...	503	Conserved Gene / Pathway	Phase 2: March 2008	2F9F	9.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00104 (show subtarget assignments)	1	purified	No	NT01SF3305	30042319	srlB	PTS system, glucitol/sorbitol-specific e...	123	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2F9H	25.2%	Shigella flexneri	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04621 (show subtarget assignments)	1	cloned	No	BAS4494	49187489		acetyl-CoA carboxylase carboxyltransfera...	324	Proposed to be essential proteins	Phase 4: April 2009	2F9I	60.2%	Bacillus anthracis

IDP04638 (show subtarget assignments)	1	expressed	No	FTT0372c	56707523	accD	Acetyl-CoA carboxylase beta subunit [Fra...	302	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	60.3%	Francisella tularensis

IDP00116 (show subtarget assignments)	0	work_stopped	No	NT01ST0285	16763622	accA	acetylCoA carboxylase, carboxytransferas...	319	Essential	Phase 1: October 2007	2F9Y	96.9%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04123 (show subtarget assignments)	1	expressed	No	YPO2768	115348451	accD	acetyl-coenzyme A carboxylase carboxyl t...	304	conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	84.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90833 (show subtarget assignments)	8	expressed	No	YPO1060	16121360	accA	acetyl-CoA carboxylase carboxyltransfera...	319	Predicted Essential	Community Requests	2F9Y	89.7%	Yersinia pestis

IDP04171 (show subtarget assignments)	1	cloned	No	VC2244	15642242		acetyl-CoA carboxylase carboxyltransfera...	319	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01488 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0572	15601331	ddl	D-alanyl-alanine synthetase A	334	Conserved Gene / Pathway	Phase 2: March 2008	2FB9	34.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91319 (show subtarget assignments)	8	soluble	No	VV2_0325	27366768		transcriptional regulator [Vibrio vulnif...	161	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2FBK	28.9%	Vibrio vulnificus

IDP00911 (show subtarget assignments)	1	expressed	No	STM0191	16763581	fhuA	ferrichrome outer membrane transporter	729	Conserved Gene / Pathway	Phase 2: March 2008	2FCP	72.3%	Salmonella enterica	Cell envelope	Other

IDP02786 (show subtarget assignments)	1	purified	No	Cj0322	15791690	perR	FUR family transcriptional regulator [Ca...	136	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2FE3	32.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00725 (show subtarget assignments)	1	cloned	No	SACOL1919	57284837		transcriptional regulator, Fur family	148	Conserved Gene / Pathway	Phase 2: March 2008	2FE3	63.5%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP00861 (show subtarget assignments)	1	purified	No	STM2117	16765447	wzb	tyrosine phosphatase	149	Conserved Gene / Pathway	Phase 2: March 2008	2FEK	81.9%	Salmonella enterica	Central intermediary metabolism	Other

IDP01975 (show subtarget assignments)	1	cloned	No	Cj1442c	15792760		hypothetical protein Cj1442c [Campylobac...	544	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2FFU	10.5%	Campylobacter jejuni	Central intermediary metabolism	Other

IDP91728 (show subtarget assignments)	8	selected	No	NP_647593	21536400	BIN1	myc box-dependent-interacting protein 1 ...	593	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2FIC	40.6%	Homo sapiens

IDP04717 (show subtarget assignments)	1	cloned	No	YPO0832	218928008	agaZ	putative tagatose 6-phosphate kinase [Ye...	432	conserved gene; putative drug target function;	Phase 4: April 2009	2FIQ	51.6%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP00108 (show subtarget assignments)	1	purified	No	NT01SF4751	30043076	fdhE	FdhE protein	309	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FIY	39.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP01029 (show subtarget assignments)	0	work_stopped	No	STM1916	16765258	cheY	chemotaxis regulator transmitting signal...	129	Conserved Gene / Pathway	Phase 2: March 2008	2FKA	100%	Salmonella enterica	Cellular processes	Other

IDP04326 (show subtarget assignments)	8	purified	No	CAC05800	12329069	ipaA	IpaA, secreted by the Mxi-Spa machinery,...	633	Shigella effector protein	Community Requests	2FM8	10.7%	Shigella flexneri

IDP01860 (show subtarget assignments)	1	cloned	No	Cj1294	15792617		DegT family aminotransferase [Campylobac...	376	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	2FN6	44.7%	Campylobacter jejuni	Protein synthesis	tRNA aminoacylation

IDP00626 (show subtarget assignments)	1	cloned	No	SACOL2506	57285191	sarT	staphylococcal accessory regulator T	118	Conserved Gene / Pathway	Phase 2: March 2008	2FNP	33.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP90203 (show subtarget assignments)	8	selected	No	AAM13658.1	20153197	CPXV220 CDS	CPXV220 protein	579	ankyrin-like protein	Community Requests	2FO1	10.4%	Cowpox virus	conserved hypothetical proteins	0

IDP91307 (show subtarget assignments)	8	expressed	No	VP1663	28898437		putative YscY [Vibrio parahaemolyticus R...	114	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2FO7	22.8%	Vibrio parahaemolyticus

IDP02624 (show subtarget assignments)	1	soluble	No	FTT1562	56708589	ispA	geranyltranstransferase [Francisella tul...	293	Conserved; Drug target functions	Phase 3: June 2008	2FOR	40.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90890 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3176	16123338	ispA	geranyltranstransferase [Yersinia pestis...	306	Predicted Essential	Community Requests	2FOR	70.9%	Yersinia pestis

IDP91707 (show subtarget assignments)	8	selected	No	NP_005447	4885433	MAPK8IP1	C-Jun-amino-terminal kinase-interacting ...	711	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2FPF	9.8%	Homo sapiens

IDP05128 (show subtarget assignments)	1	soluble	No	BA_5530	30259989		conserved hypothetical protein [Bacillus...	236	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FPN	29.2%	Bacillus anthracis	Hypothetical proteins: Conserved

IDP01700 (show subtarget assignments)	1	expressed	No	CBU_1899	29542456		methyltransferase, putative [Coxiella bu...	193	Conserved; Drug target functions	Phase 3: June 2008	2FPO	51%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP00072 (show subtarget assignments)	1	purified	No	NT01ST2585	16420605	hisB	imidazole glycerol-phosphate dehydratase...	355	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FPR	43.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00926 (show subtarget assignments)	1	soluble	No	STM0597	16763974	entB	2,3-dihydro-2,3-dihydroxybenzoate synthe...	285	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	88.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01399 (show subtarget assignments)	1	in_crystallization_trials	No	VC0771	15640790		vibriobactin-specific isochorismatase	293	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	44.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04677 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2371	47527666	dhbB	isochorismatase [Bacillus anthracis str....	295	putative drug target function;	Phase 4: April 2009	2FQ1	45.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05726 (show subtarget assignments)	1	soluble	No	BA_3927	30258439		lipoprotein, Bmp family [Bacillus anthra...	355	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	37.7%	Bacillus anthracis	Cell envelope: Other

IDP05231 (show subtarget assignments)	1	purified	No	lmo1388	16803428	tcsA	CD4+ T cell-stimulating antigen, lipopro...	346	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	39.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05098 (show subtarget assignments)	1	purified	No	CD0569	126698147		putative outer membrane lipoprotein [Clo...	334	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	21.3%	Clostridium difficile	Cell envelope: Other

IDP91971 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100002131	298254398		lipoprotein [Streptococcus pneumoniae st...	350	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2FQW	35.4%	Streptococcus pneumoniae

IDP02061 (show subtarget assignments)	1	cloned	No	CBU_0147	29540767	secA	preprotein translocase, SecA subunit [Co...	913	Conserved; Drug target functions	Phase 3: June 2008	2FSF	59.9%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01727 (show subtarget assignments)	1	cloned	No	FTT0769	56707883	secA	preprotein translocase subunit SecA [Fra...	906	Drug Target	Phase 3: June 2008	2FSF	53.4%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP91422 (show subtarget assignments)	8	soluble	No	VV1_0569	27364031	secA	preprotein translocase subunit SecA [Vib...	907	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2FSF	68.5%	Vibrio vulnificus

IDP02723 (show subtarget assignments)	1	cloned	No	FTT0039	56707219	nuoI	NADH dehydrogenase subunit I [Francisell...	162	Conserved; Drug target functions	Phase 3: June 2008	2FUG	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP02178 (show subtarget assignments)	1	soluble	No	FTT0032	56707212	nuoB	NADH dehydrogenase subunit B [Francisell...	158	Drug Target	Phase 3: June 2008	2FUG	53.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP04417 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0033	56707213	nuoC	NADH dehydrogenase I [Francisella tulare...	216	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2FUG	21.8%	Francisella tularensis

IDP02316 (show subtarget assignments)	1	soluble	No	FTT0037	56707217	nuoG	NADH dehydrogenase subunit G [Francisell...	788	Conserved; Drug target functions	Phase 3: June 2008	2FUG	24.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02299 (show subtarget assignments)	1	cloned	No	FTT0034	56707214	nuoD	NADH dehydrogenase subunit D [Francisell...	417	Drug Target	Phase 3: June 2008	2FUG	42.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP00556 (show subtarget assignments)	1	cloned	No	YPO2686	16122891	pgm	phosphoglucomutase	547	Drug Target Function	Phase 2: March 2008	2FUV	82.4%	Yersinia pestis	Energy metabolism	Sugars

IDP00133 (show subtarget assignments)	1	purified	No	VC_2095	9656644	VC2095	Vibrio cholerae O1 biovar eltor str. N16...	548	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FUV	70.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP01144 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5153	30259639		phosphoglucomutase/phosphomannomutase fa...	574	Drug Target Function	Phase 2: March 2008	2FUV	26.3%	Bacillus anthracis	Energy metabolism	Sugars

IDP00558 (show subtarget assignments)	1	purified	No	YPO0654	16120979	rfaE	bifunctional heptose 7-phosphate kinase/...	476	Conserved Gene / Pathway	Phase 2: March 2008	2FV7	16.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00927 (show subtarget assignments)	1	soluble	No	STM0598	16763975	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2FWM	89.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04313 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2368	47527663	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	258	virulence factor; putative drug target function;	Phase 4: April 2009	2FWM	45.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP92010 (show subtarget assignments)	8	selected	No	TGME49_069660	237832699		TFIIH basal transcription factor complex...	997	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2FWR	12.2%	Toxoplasma gondii

IDP90983 (show subtarget assignments)	8	selected	No	y0870	22124781	katG	catalase-peroxidase [Yersinia pestis KIM...	751	virulence/pathogenesis / stress response protein and antigen in Y pestis	Community Requests	2FXG	59.4%	Yersinia pestis

IDP01303 (show subtarget assignments)	1	purified	No	VC0573	15640595		ubiquinol--cytochrome c reductase, iron-...	197	Conserved Gene / Pathway	Phase 2: March 2008	2FYN	37.6%	Vibrio cholerae	Energy metabolism	Electron transport

IDP90617 (show subtarget assignments)	8	crystallized	No	YPO3927	16124057	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	334	Predicted Essential	Community Requests	2G17	78.1%	Yersinia pestis

IDP90906 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3183	16123345	ribD	bifunctional diaminohydroxyphosphoribosy...	369	Predicted Essential	Community Requests	2G6V	71.8%	Yersinia pestis

IDP90898 (show subtarget assignments)	8	soluble	No	STM0416	16763796	ribD	bifunctional diaminohydroxyphosphoribosy...	367	Predicted Essential	Community Requests	2G6V	89.4%	Salmonella enterica

IDP00091 (show subtarget assignments)	0	work_stopped	No	NTL01SF0342	30040153	ribD	bifunctional pyrimidine deaminase/reduct...	367	Essential	Phase 1: October 2007	2G6V	97.8%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05205 (show subtarget assignments)	1	cloned	No	CD1770	126699379	ogt2	methylated-DNA--protein-cysteine methylt...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2G7H	32.3%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP00103 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF3270	30042295	ygaC	hypothetical protein S2885	114	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2G7J	86.8%	Shigella flexneri	Cell envelope	Other

IDP00646 (show subtarget assignments)	1	selected	No	SACOL0887	57284346	sei	staphylococcal enterotoxin type I	242	Virulence Associated Factor	Phase 2: March 2008	2G9H	55%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00462 (show subtarget assignments)	1	soluble	No	YPO1025	16121325	mltA	murein transglycosylase A	390	Drug Target Function	Phase 2: March 2008	2GAE	62.8%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05323 (show subtarget assignments)	1	cloned	No	lmo1275	16803315	topA	DNA topoisomerase I [Listeria monocytoge...	692	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2GAI	38.4%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP90582 (show subtarget assignments)	8	soluble	No	Cj1686c	15792989	topA	DNA topoisomerase I [Campylobacter jejun...	700	Predicted Essential	Community Requests	2GAI	38.6%	Campylobacter jejuni

IDP04275 (show subtarget assignments)	1	cloned	No	BAS3684	49186683		DNA topoisomerase I [Bacillus anthracis ...	692	Proposed to be essential proteins	Phase 4: April 2009	2GAI	38.2%	Bacillus anthracis

IDP04477 (show subtarget assignments)	1	soluble	No	YPO2829	115348505	purN	putative phosphoribosylglycinamide formy...	212	conserved gene; putative drug target function;	Phase 4: April 2009	2GAR	71.7%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02059 (show subtarget assignments)	1	expressed	No	YPO1353	16121633		chorismate mutase [Yersinia pestis CO92]...	186	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2GBB	83.9%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP91298 (show subtarget assignments)	8	cloned	No	STM1269	16764620	-	chorismate mutase	181	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2GBB	27.6%	Salmonella enterica

IDP00454 (show subtarget assignments)	1	expressed	No	YPO0133	16120476	feoA	ferrous iron transport protein A	75	Virulence Associated Factor	Phase 2: March 2008	2GCX	70.7%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP00230 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3444	16123592	-	putative acetyltransferase	167	Virulence	Phase 1: October 2007	2GE3	18%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP05730 (show subtarget assignments)	1	soluble	No	CD0675	126698254		putative acetyltransferase [Clostridium ...	166	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2GE3	31.3%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP01972 (show subtarget assignments)	1	cloned	No	CBU_0841	29541435		glycosyl transferase, group 1 family pro...	377	Conserved; Drug target functions	Phase 3: June 2008	2GEJ	24.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02792 (show subtarget assignments)	1	cloned	No	FTT1461c	56708502	wbtD	galacturonosyl transferase [Francisella ...	363	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2GEJ	18.5%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02297 (show subtarget assignments)	1	cloned	No	FTT1235c	56708297	lpcC	glycosyl transferase group 1 family prot...	354	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2GEJ	17.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00071 (show subtarget assignments)	0	work_stopped	No	NT01ST2260	16420352	yeaZ	putative molecular chaperone	231	Essential	Phase 1: October 2007	2GEL	100%	Salmonella enterica	Unknown function	General

IDP04215 (show subtarget assignments)	1	cloned	No	STM1574_1_495	16764918	smvA	methyl viologen resistance [Salmonella t...	495	Salmonella essential protein	Phase 4: April 2009	2GFP	17%	Salmonella enterica

IDP02130 (show subtarget assignments)	1	cloned	No	Cj1416c	15792734		putative sugar nucleotidyltransferase [C...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	25.7%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01938 (show subtarget assignments)	1	purified	No	Cj1423c	15792741		putative sugar-phosphate nucleotidyltran...	221	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	33.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02663 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2182	16804221		hypothetical protein lmo2182 [Listeria m...	259	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2GHI	30.9%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP04580 (show subtarget assignments)	1	cloned	No	BAS0103	49183137		DNA-directed RNA polymerase subunit beta...	1203	Proposed to be essential proteins	Phase 4: April 2009	2GHO	53.6%	Bacillus anthracis

IDP02115 (show subtarget assignments)	1	purified	No	FTT0900	56708001		hypothetical protein FTT0900 [Francisell...	123	Drug Target	Community Requests	2GM2	22.8%	Francisella tularensis	Cell envelope	Other

IDP02104 (show subtarget assignments)	1	soluble	No	YPO1074	16121375		D,D-heptose 1,7-bisphosphate phosphatase...	188	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2GMW	80.9%	Yersinia pestis	Unknown function	General

IDP01856 (show subtarget assignments)	1	expressed	No	Cj1152c	15792476		putative phosphatase [Campylobacter jeju...	186	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2GMW	37.1%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP05213 (show subtarget assignments)	1	soluble	No	CD2769	126700385		capsular polysaccharide biosynthesis pro...	597	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2GN4	17.4%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02553 (show subtarget assignments)	1	cloned	No	Cj1293	15792616		polysaccharide biosynthesis protein [Cam...	334	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	2GN4	63.5%	Campylobacter jejuni	Energy metabolism	Glycolysis/gluconeogenesis

IDP00758 (show subtarget assignments)	1	soluble	No	SACOL0140	57285343	cap5E	capsular polysaccharide biosynthesis pro...	342	Conserved Gene / Pathway	Phase 2: March 2008	2GN4	38%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02631 (show subtarget assignments)	1	expressed	No	GBAA1440	47526715	cysH	phosphoadenosine phosphosulfate reductas...	226	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GOY	37.6%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP02336 (show subtarget assignments)	1	expressed	No	YPO2533	16122751	edd	phosphogluconate dehydratase [Yersinia p...	625	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2GP4	63.8%	Yersinia pestis	Energy metabolism	Entner-Doudoroff

IDP00132 (show subtarget assignments)	1	purified	No	VC_0288	9654699	VC0288	Vibrio cholerae O1 biovar eltor str. N16...	618	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GP4	53.9%	Vibrio cholerae	Energy metabolism	Entner-Doudoroff

IDP91256 (show subtarget assignments)	8	cloned	No	NT02SA0972	14246753		3-oxoacyl synthase [Staphylococcus aureu...	414	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2GQD	99.8%	Staphylococcus aureus	Energy metabolism: ATP-proton motive force interconversion

IDP00125 (show subtarget assignments)	0	work_stopped	No	NT01ST1183	16764320	lrp	leucine-responsive transcriptional regul...	164		Phase 1: October 2007	2GQQ	98.8%	Salmonella enterica	Central intermediary metabolism	Other

IDP00094 (show subtarget assignments)	0	work_stopped	No	NT01SF0993	30040622	lrp	regulator for leucine (or lrp) regulon a...	164		Phase 1: October 2007	2GQQ	99.4%	Shigella flexneri	Central intermediary metabolism	Other

IDP04362 (show subtarget assignments)	1	soluble	No	YPO3059	218930104	purC	phosphoribosylaminoimidazole-succinocarb...	237	conserved gene; putative drug target function;	Phase 4: April 2009	2GQR	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05265
(show subtarget assignments)

1

purified

No

CD3543

126701167

putative nicotinate phosphribosyltransfe...

476

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2F7F

43.3%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04595
(show subtarget assignments)

1

soluble

No

BAS0565

49183590

nicotinate phosphoribosyltransferase [Ba...

487

Proposed to be essential proteins

Phase 4: April 2009

2F7F

61.4%

Bacillus anthracis

IDP02419
(show subtarget assignments)

1

purified

No

FTT1447c

56708489

manB

phosphomannomutase [Francisella tularens...

494

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2F7L

25.7%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP90249
(show subtarget assignments)

8

soluble

No

VC2645

15642640

acetylornithine deacetylase [Vibrio chol...

378

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2F7V

26.8%

Vibrio cholerae

IDP90251
(show subtarget assignments)

8

expressed

No

SF4034

56480493

argE

acetylornithine deacetylase [Shigella fl...

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2F7V

25.1%

Shigella flexneri

IDP92040
(show subtarget assignments)

8

selected

No

TGME49_039310

237834547

ribose 5-phosphate isomerase, putative [...

259

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F8M

42.5%

Toxoplasma gondii

IDP00753
(show subtarget assignments)

1

cloned

No

SACOL0052

57286607

glycosyl transferase, group 1 family pro...

503

Conserved Gene / Pathway

Phase 2: March 2008

2F9F

9.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00104
(show subtarget assignments)

1

purified

No

NT01SF3305

30042319

srlB

PTS system, glucitol/sorbitol-specific e...

123

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2F9H

25.2%

Shigella flexneri

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04621
(show subtarget assignments)

1

cloned

No

BAS4494

49187489

acetyl-CoA carboxylase carboxyltransfera...

324

Proposed to be essential proteins

Phase 4: April 2009

2F9I

60.2%

Bacillus anthracis

IDP04638
(show subtarget assignments)

1

expressed

No

FTT0372c

56707523

accD

Acetyl-CoA carboxylase beta subunit [Fra...

302

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

60.3%

Francisella tularensis

IDP00116
(show subtarget assignments)

0

work_stopped

No

NT01ST0285

16763622

accA

acetylCoA carboxylase, carboxytransferas...

319

Essential

Phase 1: October 2007

2F9Y

96.9%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04123
(show subtarget assignments)

1

expressed

No

YPO2768

115348451

accD

acetyl-coenzyme A carboxylase carboxyl t...

304

conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

84.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90833
(show subtarget assignments)

8

expressed

No

YPO1060

16121360

accA

acetyl-CoA carboxylase carboxyltransfera...

319

Predicted Essential

Community Requests

2F9Y

89.7%

Yersinia pestis

IDP04171
(show subtarget assignments)

1

cloned

No

VC2244

15642242

acetyl-CoA carboxylase carboxyltransfera...

319

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01488
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0572

15601331

ddl

D-alanyl-alanine synthetase A

334

Conserved Gene / Pathway

Phase 2: March 2008

2FB9

34.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91319
(show subtarget assignments)

8

soluble

No

VV2_0325

27366768

transcriptional regulator [Vibrio vulnif...

161

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2FBK

28.9%

Vibrio vulnificus

IDP00911
(show subtarget assignments)

1

expressed

No

STM0191

16763581

fhuA

ferrichrome outer membrane transporter

729

Conserved Gene / Pathway

Phase 2: March 2008

2FCP

72.3%

Salmonella enterica

Cell envelope

Other

IDP02786
(show subtarget assignments)

1

purified

No

Cj0322

15791690

perR

FUR family transcriptional regulator [Ca...

136

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2FE3

32.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00725
(show subtarget assignments)

1

cloned

No

SACOL1919

57284837

transcriptional regulator, Fur family

148

Conserved Gene / Pathway

Phase 2: March 2008

2FE3

63.5%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP00861
(show subtarget assignments)

1

purified

No

STM2117

16765447

wzb

tyrosine phosphatase

149

Conserved Gene / Pathway

Phase 2: March 2008

2FEK

81.9%

Salmonella enterica

Central intermediary metabolism

Other

IDP01975
(show subtarget assignments)

1

cloned

No

Cj1442c

15792760

hypothetical protein Cj1442c [Campylobac...

544

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2FFU

10.5%

Campylobacter jejuni

Central intermediary metabolism

Other

IDP91728
(show subtarget assignments)

8

selected

No

NP_647593

21536400

BIN1

myc box-dependent-interacting protein 1 ...

593

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2FIC

40.6%

Homo sapiens

IDP04717
(show subtarget assignments)

1

cloned

No

YPO0832

218928008

agaZ

putative tagatose 6-phosphate kinase [Ye...

432

conserved gene; putative drug target function;

Phase 4: April 2009

2FIQ

51.6%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP00108
(show subtarget assignments)

1

purified

No

NT01SF4751

30043076

fdhE

FdhE protein

309

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FIY

39.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP01029
(show subtarget assignments)

0

work_stopped

No

STM1916

16765258

cheY

chemotaxis regulator transmitting signal...

129

Conserved Gene / Pathway

Phase 2: March 2008

2FKA

100%

Salmonella enterica

Cellular processes

Other

IDP04326
(show subtarget assignments)

8

purified

No

CAC05800

12329069

ipaA

IpaA, secreted by the Mxi-Spa machinery,...

633

Shigella effector protein

Community Requests

2FM8

10.7%

Shigella flexneri

IDP01860
(show subtarget assignments)

1

cloned

No

Cj1294

15792617

DegT family aminotransferase [Campylobac...

376

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

2FN6

44.7%

Campylobacter jejuni

Protein synthesis

tRNA aminoacylation

IDP00626
(show subtarget assignments)

1

cloned

No

SACOL2506

57285191

sarT

staphylococcal accessory regulator T

118

Conserved Gene / Pathway

Phase 2: March 2008

2FNP

33.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP90203
(show subtarget assignments)

8

selected

No

AAM13658.1

20153197

CPXV220 CDS

CPXV220 protein

579

ankyrin-like protein

Community Requests

2FO1

10.4%

Cowpox virus

conserved hypothetical proteins

0

IDP91307
(show subtarget assignments)

8

expressed

No

VP1663

28898437

putative YscY [Vibrio parahaemolyticus R...

114

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2FO7

22.8%

Vibrio parahaemolyticus

IDP02624
(show subtarget assignments)

1

soluble

No

FTT1562

56708589

ispA

geranyltranstransferase [Francisella tul...

293

Conserved; Drug target functions

Phase 3: June 2008

2FOR

40.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90890
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3176

16123338

ispA

geranyltranstransferase [Yersinia pestis...

306

Predicted Essential

Community Requests

2FOR

70.9%

Yersinia pestis

IDP91707
(show subtarget assignments)

8

selected

No

NP_005447

4885433

MAPK8IP1

C-Jun-amino-terminal kinase-interacting ...

711

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2FPF

9.8%

Homo sapiens

IDP05128
(show subtarget assignments)

1

soluble

No

BA_5530

30259989

conserved hypothetical protein [Bacillus...

236

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FPN

29.2%

Bacillus anthracis

Hypothetical proteins: Conserved

IDP01700
(show subtarget assignments)

1

expressed

No

CBU_1899

29542456

methyltransferase, putative [Coxiella bu...

193

Conserved; Drug target functions

Phase 3: June 2008

2FPO

51%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP00072
(show subtarget assignments)

1

purified

No

NT01ST2585

16420605

hisB

imidazole glycerol-phosphate dehydratase...

355

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FPR

43.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00926
(show subtarget assignments)

1

soluble

No

STM0597

16763974

entB

2,3-dihydro-2,3-dihydroxybenzoate synthe...

285

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

88.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01399
(show subtarget assignments)

1

in_crystallization_trials

No

VC0771

15640790

vibriobactin-specific isochorismatase

293

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

44.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04677
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2371

47527666

dhbB

isochorismatase [Bacillus anthracis str....

295

putative drug target function;

Phase 4: April 2009

2FQ1

45.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05726
(show subtarget assignments)

1

soluble

No

BA_3927

30258439

lipoprotein, Bmp family [Bacillus anthra...

355

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

37.7%

Bacillus anthracis

Cell envelope: Other

IDP05231
(show subtarget assignments)

1

purified

No

lmo1388

16803428

tcsA

CD4+ T cell-stimulating antigen, lipopro...

346

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

39.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05098
(show subtarget assignments)

1

purified

No

CD0569

126698147

putative outer membrane lipoprotein [Clo...

334

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

21.3%

Clostridium difficile

Cell envelope: Other

IDP91971
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100002131

298254398

lipoprotein [Streptococcus pneumoniae st...

350

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2FQW

35.4%

Streptococcus pneumoniae

IDP02061
(show subtarget assignments)

1

cloned

No

CBU_0147

29540767

secA

preprotein translocase, SecA subunit [Co...

913

Conserved; Drug target functions

Phase 3: June 2008

2FSF

59.9%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01727
(show subtarget assignments)

1

cloned

No

FTT0769

56707883

secA

preprotein translocase subunit SecA [Fra...

906

Drug Target

Phase 3: June 2008

2FSF

53.4%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP91422
(show subtarget assignments)

8

soluble

No

VV1_0569

27364031

secA

preprotein translocase subunit SecA [Vib...

907

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2FSF

68.5%

Vibrio vulnificus

IDP02723
(show subtarget assignments)

1

cloned

No

FTT0039

56707219

nuoI

NADH dehydrogenase subunit I [Francisell...

162

Conserved; Drug target functions

Phase 3: June 2008

2FUG

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP02178
(show subtarget assignments)

1

soluble

No

FTT0032

56707212

nuoB

NADH dehydrogenase subunit B [Francisell...

158

Drug Target

Phase 3: June 2008

2FUG

53.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP04417
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0033

56707213

nuoC

NADH dehydrogenase I [Francisella tulare...

216

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2FUG

21.8%

Francisella tularensis

IDP02316
(show subtarget assignments)

1

soluble

No

FTT0037

56707217

nuoG

NADH dehydrogenase subunit G [Francisell...

788

Conserved; Drug target functions

Phase 3: June 2008

2FUG

24.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02299
(show subtarget assignments)

1

cloned

No

FTT0034

56707214

nuoD

NADH dehydrogenase subunit D [Francisell...

417

Drug Target

Phase 3: June 2008

2FUG

42.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP00556
(show subtarget assignments)

1

cloned

No

YPO2686

16122891

pgm

phosphoglucomutase

547

Drug Target Function

Phase 2: March 2008

2FUV

82.4%

Yersinia pestis

Energy metabolism

Sugars

IDP00133
(show subtarget assignments)

1

purified

No

VC_2095

9656644

VC2095

Vibrio cholerae O1 biovar eltor str. N16...

548

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FUV

70.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP01144
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5153

30259639

phosphoglucomutase/phosphomannomutase fa...

574

Drug Target Function

Phase 2: March 2008

2FUV

26.3%

Bacillus anthracis

Energy metabolism

Sugars

IDP00558
(show subtarget assignments)

1

purified

No

YPO0654

16120979

rfaE

bifunctional heptose 7-phosphate kinase/...

476

Conserved Gene / Pathway

Phase 2: March 2008

2FV7

16.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00927
(show subtarget assignments)

1

soluble

No

STM0598

16763975

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2FWM

89.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04313
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2368

47527663

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

258

virulence factor; putative drug target function;

Phase 4: April 2009

2FWM

45.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP92010
(show subtarget assignments)

8

selected

No

TGME49_069660

237832699

TFIIH basal transcription factor complex...

997

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2FWR

12.2%

Toxoplasma gondii

IDP90983
(show subtarget assignments)

8

selected

No

y0870

22124781

katG

catalase-peroxidase [Yersinia pestis KIM...

751

virulence/pathogenesis / stress response protein and antigen in Y pestis

Community Requests

2FXG

59.4%

Yersinia pestis

IDP01303
(show subtarget assignments)

1

purified

No

VC0573

15640595

ubiquinol--cytochrome c reductase, iron-...

197

Conserved Gene / Pathway

Phase 2: March 2008

2FYN

37.6%

Vibrio cholerae

Energy metabolism

Electron transport

IDP90617
(show subtarget assignments)

8

crystallized

No

YPO3927

16124057

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

334

Predicted Essential

Community Requests

2G17

78.1%

Yersinia pestis

IDP90906
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3183

16123345

ribD

bifunctional diaminohydroxyphosphoribosy...

369

Predicted Essential

Community Requests

2G6V

71.8%

Yersinia pestis

IDP90898
(show subtarget assignments)

8

soluble

No

STM0416

16763796

ribD

bifunctional diaminohydroxyphosphoribosy...

367

Predicted Essential

Community Requests

2G6V

89.4%

Salmonella enterica

IDP00091
(show subtarget assignments)

0

work_stopped

No

NTL01SF0342

30040153

ribD

bifunctional pyrimidine deaminase/reduct...

367

Essential

Phase 1: October 2007

2G6V

97.8%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05205
(show subtarget assignments)

1

cloned

No

CD1770

126699379

ogt2

methylated-DNA--protein-cysteine methylt...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2G7H

32.3%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP00103
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF3270

30042295

ygaC

hypothetical protein S2885

114

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2G7J

86.8%

Shigella flexneri

Cell envelope

Other

IDP00646
(show subtarget assignments)

1

selected

No

SACOL0887

57284346

sei

staphylococcal enterotoxin type I

242

Virulence Associated Factor

Phase 2: March 2008

2G9H

55%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00462
(show subtarget assignments)

1

soluble

No

YPO1025

16121325

mltA

murein transglycosylase A

390

Drug Target Function

Phase 2: March 2008

2GAE

62.8%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05323
(show subtarget assignments)

1

cloned

No

lmo1275

16803315

topA

DNA topoisomerase I [Listeria monocytoge...

692

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2GAI

38.4%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP90582
(show subtarget assignments)

8

soluble

No

Cj1686c

15792989

topA

DNA topoisomerase I [Campylobacter jejun...

700

Predicted Essential

Community Requests

2GAI

38.6%

Campylobacter jejuni

IDP04275
(show subtarget assignments)

1

cloned

No

BAS3684

49186683

DNA topoisomerase I [Bacillus anthracis ...

692

Proposed to be essential proteins

Phase 4: April 2009

2GAI

38.2%

Bacillus anthracis

IDP04477
(show subtarget assignments)

1

soluble

No

YPO2829

115348505

purN

putative phosphoribosylglycinamide formy...

212

conserved gene; putative drug target function;

Phase 4: April 2009

2GAR

71.7%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02059
(show subtarget assignments)

1

expressed

No

YPO1353

16121633

chorismate mutase [Yersinia pestis CO92]...

186

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2GBB

83.9%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP91298
(show subtarget assignments)

8

cloned

No

STM1269

16764620

-

chorismate mutase

181

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2GBB

27.6%

Salmonella enterica

IDP00454
(show subtarget assignments)

1

expressed

No

YPO0133

16120476

feoA

ferrous iron transport protein A

75

Virulence Associated Factor

Phase 2: March 2008

2GCX

70.7%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP00230
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3444

16123592

-

putative acetyltransferase

167

Virulence

Phase 1: October 2007

2GE3

18%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP05730
(show subtarget assignments)

1

soluble

No

CD0675

126698254

putative acetyltransferase [Clostridium ...

166

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2GE3

31.3%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP01972
(show subtarget assignments)

1

cloned

No

CBU_0841

29541435

glycosyl transferase, group 1 family pro...

377

Conserved; Drug target functions

Phase 3: June 2008

2GEJ

24.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02792
(show subtarget assignments)

1

cloned

No

FTT1461c

56708502

wbtD

galacturonosyl transferase [Francisella ...

363

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2GEJ

18.5%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02297
(show subtarget assignments)

1

cloned

No

FTT1235c

56708297

lpcC

glycosyl transferase group 1 family prot...

354

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2GEJ

17.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00071
(show subtarget assignments)

0

work_stopped

No

NT01ST2260

16420352

yeaZ

putative molecular chaperone

231

Essential

Phase 1: October 2007

2GEL

100%

Salmonella enterica

Unknown function

General

IDP04215
(show subtarget assignments)

1

cloned

No

STM1574_1_495

16764918

smvA

methyl viologen resistance [Salmonella t...

495

Salmonella essential protein

Phase 4: April 2009

2GFP

17%

Salmonella enterica

IDP02130
(show subtarget assignments)

1

cloned

No

Cj1416c

15792734

putative sugar nucleotidyltransferase [C...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

25.7%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01938
(show subtarget assignments)

1

purified

No

Cj1423c

15792741

putative sugar-phosphate nucleotidyltran...

221

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

33.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02663
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2182

16804221

hypothetical protein lmo2182 [Listeria m...

259

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2GHI

30.9%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP04580
(show subtarget assignments)

1

cloned

No

BAS0103

49183137

DNA-directed RNA polymerase subunit beta...

1203

Proposed to be essential proteins

Phase 4: April 2009

2GHO

53.6%

Bacillus anthracis

IDP02115
(show subtarget assignments)

1

purified

No

FTT0900

56708001

hypothetical protein FTT0900 [Francisell...

123

Drug Target

Community Requests

2GM2

22.8%

Francisella tularensis

Cell envelope

Other

IDP02104
(show subtarget assignments)

1

soluble

No

YPO1074

16121375

D,D-heptose 1,7-bisphosphate phosphatase...

188

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2GMW

80.9%

Yersinia pestis

Unknown function

General

IDP01856
(show subtarget assignments)

1

expressed

No

Cj1152c

15792476

putative phosphatase [Campylobacter jeju...

186

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2GMW

37.1%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP05213
(show subtarget assignments)

1

soluble

No

CD2769

126700385

capsular polysaccharide biosynthesis pro...

597

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2GN4

17.4%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02553
(show subtarget assignments)

1

cloned

No

Cj1293

15792616

polysaccharide biosynthesis protein [Cam...

334

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

2GN4

63.5%

Campylobacter jejuni

Energy metabolism

Glycolysis/gluconeogenesis

IDP00758
(show subtarget assignments)

1

soluble

No

SACOL0140

57285343

cap5E

capsular polysaccharide biosynthesis pro...

342

Conserved Gene / Pathway

Phase 2: March 2008

2GN4

38%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02631
(show subtarget assignments)

1

expressed

No

GBAA1440

47526715

cysH

phosphoadenosine phosphosulfate reductas...

226

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GOY

37.6%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP02336
(show subtarget assignments)

1

expressed

No

YPO2533

16122751

edd

phosphogluconate dehydratase [Yersinia p...

625

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2GP4

63.8%

Yersinia pestis

Energy metabolism

Entner-Doudoroff

IDP00132
(show subtarget assignments)

1

purified

No

VC_0288

9654699

VC0288

Vibrio cholerae O1 biovar eltor str. N16...

618

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GP4

53.9%

Vibrio cholerae

Energy metabolism

Entner-Doudoroff

IDP91256
(show subtarget assignments)

8

cloned

No

NT02SA0972

14246753

3-oxoacyl synthase [Staphylococcus aureu...

414

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2GQD

99.8%

Staphylococcus aureus

Energy metabolism: ATP-proton motive force interconversion

IDP00125
(show subtarget assignments)

0

work_stopped

No

NT01ST1183

16764320

lrp

leucine-responsive transcriptional regul...

164

Phase 1: October 2007

2GQQ

98.8%

Salmonella enterica

Central intermediary metabolism

Other

IDP00094
(show subtarget assignments)

0

work_stopped

No

NT01SF0993

30040622

lrp

regulator for leucine (or lrp) regulon a...

164

Phase 1: October 2007

2GQQ

99.4%

Shigella flexneri

Central intermediary metabolism

Other

IDP04362
(show subtarget assignments)

1

soluble

No

YPO3059

218930104

purC

phosphoribosylaminoimidazole-succinocarb...

237

conserved gene; putative drug target function;

Phase 4: April 2009

2GQR

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis