Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90582 (show subtarget assignments)	8	soluble	No	Cj1686c	15792989	topA	DNA topoisomerase I [Campylobacter jejun...	700	Predicted Essential	Community Requests	2GAI	38.6%	Campylobacter jejuni

IDP91941 (show subtarget assignments)	8	selected	No	SpneCM_010100000177	298254016		ABC transporter, ATP-binding/permease pr...	588	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QF4	38.6%	Streptococcus pneumoniae

IDP90161 (show subtarget assignments)	8	purified	No	CD1835	123174273		Chorismate synthase (5-enolpyruvylshikim...	359	Potential drug target. Shikimate pathway enzyme	Community Requests	1UM0	38.7%	Clostridium difficile

IDP05147 (show subtarget assignments)	1	cloned	No	BAS4903	49187891	-	methionyl-tRNA synthetase [Bacillus anth...	544	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RQG	38.7%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP01018 (show subtarget assignments)	1	expressed	No	STM2894	16766200	invC	ATP synthase SpaL	431	Conserved Gene / Pathway	Phase 2: March 2008	2OBL	38.7%	Salmonella enterica	Transport and binding proteins	Other

IDP00979 (show subtarget assignments)	1	purified	No	STM1953	16765291	yedO	D-cysteine desulfhydrase	328	Conserved Gene / Pathway	Phase 2: March 2008	1J0A	38.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02645 (show subtarget assignments)	1	soluble	No	STM1749	16765093	adhE	bifunctional acetaldehyde-CoA/alcohol de...	892	Conserved; Essential; Drug target functions	Phase 3: June 2008	3MY7	38.7%	Salmonella enterica	Energy metabolism	Fermentation

IDP01902 (show subtarget assignments)	1	soluble	No	STM0878	16764240	potG	putrescine transporter ATP-binding subun...	377	Conserved; Drug target functions	Phase 3: June 2008	1V43	38.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP04377 (show subtarget assignments)	1	soluble	No	CPF_2652	110798678		putative maltose/maltodextrin ABC transp...	408	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1URG	38.7%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01341 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0687	15601444	fbpC	ferric transporter ATP-binding subunit	351	Conserved Gene / Pathway	Phase 2: March 2008	1V43	38.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP92565 (show subtarget assignments)	8	selected	No	AAA66406	807601		nonstructural protein 1, partial [Dengue...	886	potential drug target / Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...	Community Requests	2WZQ	38.7%	Dengue virus

IDP92128 (show subtarget assignments)	8	selected	No	TGME49_082200	237844257		clpB protein, putative [Toxoplasma gondi...	970	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QVR	38.7%	Toxoplasma gondii

IDP90658 (show subtarget assignments)	8	cloned	No	VC2503	15642499	valS	valyl-tRNA synthetase [Vibrio cholerae O...	953	Predicted Essential	Community Requests	1GAX	38.8%	Vibrio cholerae

IDP90605 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1271c	15792595	tyrS	tyrosyl-tRNA synthetase [Campylobacter j...	401	Predicted Essential	Community Requests	1H3E	38.8%	Campylobacter jejuni

IDP02007 (show subtarget assignments)	1	in_crystallization_trials	No	STM2330	16765657	lrhA	NADH dehydrogenase transcriptional repre...	312	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3ONM	38.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP91061 (show subtarget assignments)	8	purified	No	YPO3532	16123678	fklB	FKBP-type peptidyl-prolyl cis-trans isom...	206	virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...	Community Requests	1FD9	38.8%	Yersinia pestis

IDP90761 (show subtarget assignments)	8	cloned	No	Cj1061c	15792388	ileS	isoleucyl-tRNA synthetase [Campylobacter...	917	Predicted Essential	Community Requests	1FFY	38.8%	Campylobacter jejuni

IDP00683 (show subtarget assignments)	1	purified	No	SACOL1795	57286229	pepA1	glutamyl aminopeptidase	358	Drug Target Function	Phase 2: March 2008	3KL9	38.8%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90696 (show subtarget assignments)	8	in_crystallization_trials	No	YPO1022	16121323	argA	N-acetylglutamate synthase [Yersinia pes...	441	Predicted Essential	Community Requests	2R8V	38.8%	Yersinia pestis

IDP00635 (show subtarget assignments)	1	cloned	No	SACOL2270	57286396	modC	molybdenum ABC transporter, ATP-binding ...	201	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	38.8%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP02459 (show subtarget assignments)	1	soluble	No	lmo2067	16804106		hypothetical protein lmo2067 [Listeria m...	325	Known virulence-Bile resistance; PMID:15664931	Phase 3: June 2008	2BJF	38.8%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP05412 (show subtarget assignments)	1	soluble	No	BA_3584	30258112		putative microbial collagenase [Bacillus...	971	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Y3U	38.9%	Bacillus anthracis	Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05743 (show subtarget assignments)	1	cloned	No	CD2653	126700267	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	451	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3LK7	38.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90662 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1288c	15792611	gltX	glutamyl-tRNA synthetase [Campylobacter ...	463	Predicted Essential	Community Requests	2CFO	38.9%	Campylobacter jejuni

IDP02462 (show subtarget assignments)	1	expressed	No	FTT1467c	56708507	nadB	L-aspartate oxidase [Francisella tularen...	495	Conserved; Drug target functions	Phase 3: June 2008	1CHU	38.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP04173 (show subtarget assignments)	1	expressed	No	VC2490	15642486		2-isopropylmalate synthase [Vibrio chole...	516	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	39%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP90754 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0498	15791862	trpC	indole-3-glycerol phosphate synthase [Ca...	258	Predicted Essential	Community Requests	3TSM	39%	Campylobacter jejuni

IDP91787 (show subtarget assignments)	8	in_crystallization_trials	No	AAA24786	148325	vanC	D-alanine-D-alanine ligase-related prote...	343	drug resistance / D-Ala:D-Ser ligase	Community Requests	1E4E	39%	Enterococcus gallinarum

IDP00705 (show subtarget assignments)	1	cloned	No	SACOL0306	57285419		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	39%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP91332 (show subtarget assignments)	8	purified	No	VV2_0201	27366656		DNA-binding transcriptional regulator Fr...	326	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3O74	39%	Vibrio vulnificus

IDP90766 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0765c	15792103	hisS	histidyl-tRNA synthetase [Campylobacter ...	408	Predicted Essential	Community Requests	4E51	39%	Campylobacter jejuni

IDP90706 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1048c	15792375	dapE	succinyl-diaminopimelate desuccinylase [...	365	Predicted Essential	Community Requests	1VGY	39%	Campylobacter jejuni

IDP90623 (show subtarget assignments)	8	purified	No	Cj1177c	15792501	gmk	guanylate kinase [Campylobacter jejuni s...	207	Predicted Essential	Community Requests	1S96	39.1%	Campylobacter jejuni

IDP91698 (show subtarget assignments)	8	selected	No	NP_002511	10835063	NPM1	nucleophosmin isoform 1 [Homo sapiens]	294	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2P1B	39.1%	Homo sapiens

IDP00917 (show subtarget assignments)	1	cloned	No	STM0355	16763735		putative copper chaperone	64	Conserved Gene / Pathway	Phase 2: March 2008	2K2P	39.1%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP01662 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2583	16804621		hypothetical protein lmo2583 [Listeria m...	225	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2OQR	39.1%	Listeria monocytogenes	Regulatory functions	Other

IDP90277 (show subtarget assignments)	8	soluble	No	TGME49_059690	211962827		orotidine-monophosphate-decarboxylase, p...	320	The orotidine monophosphate decarboxylase (TgODCase) is the last step in de novo...	Community Requests	3QW3	39.1%	Toxoplasma gondii

IDP05020 (show subtarget assignments)	1	soluble	No	CD1027	126698611	potD	spermidine/putrescine ABC transporter,su...	350	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EQB	39.1%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP91899 (show subtarget assignments)	8	selected	No	SpneCM_010100002520	298254473		ABC transporter, ATP-binding/permease pr...	564	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QF4	39.1%	Streptococcus pneumoniae

IDP91623 (show subtarget assignments)	8	expressed	No	BAB35652	13361695	ECs2229	hypothetical protein [Escherichia coli O...	169	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	39.1%	Escherichia coli

IDP05269 (show subtarget assignments)	1	soluble	No	lmo0517	16802560	-	hypothetical protein lmo0517 [Listeria m...	271	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3R7A	39.1%	Listeria monocytogenes	Energy metabolism: Glycolysis/gluconeogenesis

IDP02320 (show subtarget assignments)	1	purified	No	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01913 (show subtarget assignments)	1	cloned	No	GBAA1426	47526698	hisD	histidinol dehydrogenase [Bacillus anthr...	429	Conserved; Drug target functions	Phase 3: June 2008	1K75	39.2%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02563 (show subtarget assignments)	1	cloned	No	GBAA3299	47528584		collagenase, putative [Bacillus anthraci...	960	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04026 (show subtarget assignments)	1	expressed	No	FTT0456c	56707598		hypothetical protein FTT_0456c [Francise...	97	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YHD	39.2%	Francisella tularensis

IDP04503 (show subtarget assignments)	1	cloned	No	VC2289	15642287		thiamin biosynthesis lipoprotein ApbE [V...	367	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3PND	39.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP01498 (show subtarget assignments)	1	expressed	No	VCA0862	15601617		long-chain fatty acid transport protein ...	412	Conserved Gene / Pathway	Phase 2: March 2008	1T16	39.2%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01430 (show subtarget assignments)	1	in_crystallization_trials	No	VC1863	15641865		amino acid ABC transporter, periplasmic ...	260	Conserved Gene / Pathway	Phase 2: March 2008	1LAF	39.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91082 (show subtarget assignments)	8	cloned	No	CPF_1776	110800219		ABC transporter, permease/ATP-binding pr...	589	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	39.2%	Clostridium perfringens

IDP02421 (show subtarget assignments)	1	purified	No	Cj0606	15791966		macrolide-specific efflux protein macA [...	390	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	4DK0	39.2%	Campylobacter jejuni	Transport and binding proteins	Other

IDP00611 (show subtarget assignments)	1	crystallized	No	SACOL1952	57286299		ferritins family protein	166	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	39.2%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP90570 (show subtarget assignments)	8	in_pdb 4EHI	No	Cj0953c	15792282	purH	bifunctional phosphoribosylaminoimidazol...	510	Predicted Essential	Community Requests	3ZZM	39.2%	Campylobacter jejuni

IDP02298 (show subtarget assignments)	1	soluble	No	GBAA0555	47525828		collagenase,putative [Bacillus anthracis...	965	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00829 (show subtarget assignments)	1	purified	No	SACOL2515	57285199	gntK	gluconokinase	517	Drug Target Function	Phase 2: March 2008	3GBT	39.3%	Staphylococcus aureus	Energy metabolism	Sugars

IDP00349 (show subtarget assignments)	1	expressed	No	lmo1632	16803672	trpG	hypothetical protein lmo1632	201	Predicted involvement in glycosyl group metabolism; Drug Target Homologs	Phase 2: March 2008	1I1Q	39.3%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP02738 (show subtarget assignments)	1	cloned	No	FTT1310c	56708367	hflB	ATP-dependent metalloprotease [Francisel...	638	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2DHR	39.3%	Francisella tularensis	N/A	N/A

IDP91081 (show subtarget assignments)	8	cloned	No	CD2817	126700433		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	39.4%	Clostridium difficile

IDP01922 (show subtarget assignments)	1	expressed	No	GBAA1441	47526716	sat	sulfate adenylyltransferase [Bacillus an...	378	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1V47	39.4%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP91240 (show subtarget assignments)	8	cloned	No	HP1280	0			335	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	39.4%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP01733 (show subtarget assignments)	1	cloned	No	FTT0811c	56707922	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	371	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1F0K	39.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01671 (show subtarget assignments)	1	cloned	No	YPO3012	16123191	cysA	sulfate/thiosulfate transporter subunit ...	363	Conserved; CD; Drug target functions	Phase 3: June 2008	1Z47	39.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00015 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4048	47605856		UDP-N-acetylenolpyruvoylglucosamine redu...	301	Drug Target Homolog	Phase 1: October 2007	1HSK	39.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02027 (show subtarget assignments)	1	soluble	No	CBU_0599	29541200	cysQ-1	3'(2'),5'-bisphosphate nucleotidase [Cox...	271	Conserved; Drug target functions	Phase 3: June 2008	3B8B	39.5%	Coxiella burnetii	Central intermediary metabolism	Sulfur metabolism

IDP91766 (show subtarget assignments)	8	expressed	No	b3441	16131313	yhhY	predicted acetyltransferase [Escherichia...	162	drug resistance; innate immunity / E.coli YhhY (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...	Community Requests	2VI7	39.5%	Escherichia coli

IDP00108 (show subtarget assignments)	1	purified	No	NT01SF4751	30043076	fdhE	FdhE protein	309	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FIY	39.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP05544 (show subtarget assignments)	1	purified	No	Cj1409	6968828	acpS	putative Ni/Fe-hydrogenase small subunit...	115	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3HYK	39.5%	Campylobacter jejuni	Fatty acid and phospholipid metabolism: Biosynthesis

IDP01639 (show subtarget assignments)	1	cloned	No	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01403 (show subtarget assignments)	1	in_crystallization_trials	No	VC0854	15640870		heat shock protein GrpE	200	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	39.5%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP91744 (show subtarget assignments)	8	selected	No	Q76ZW2_VACCW	0			190	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1OYI	39.5%	Vaccinia virus

IDP02363 (show subtarget assignments)	1	purified	No	FTT1366c	56708419	pyk	pyruvate kinase [Francisella tularensis ...	478	Conserved; Drug target functions	Phase 3: June 2008	1E0U	39.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP91283 (show subtarget assignments)	8	cloned	No	NT05BA5557	49182237		single-stranded DNA-binding protein [Bac...	172	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3VDY	39.5%	Bacillus anthracis	Mobile and extrachromosomal element functions: Prophage functions

IDP00547 (show subtarget assignments)	1	expressed	No	YPO3813	16123947	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	39.6%	Yersinia pestis	Cellular processes	Cell division

IDP01809 (show subtarget assignments)	1	purified	No	FTT0258	56707414		carboxylesterase/phospholipase family pr...	222	Drug Target	Phase 3: June 2008	1FJ2	39.6%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP02501 (show subtarget assignments)	1	cloned	No	GBAA1250	47526516	trpD	anthranilate phosphoribosyltransferase [...	341	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VQU	39.6%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP90603 (show subtarget assignments)	8	selected	No	VC0015	15640047	gyrB	DNA gyrase subunit B [Vibrio cholerae O1...	805	Predicted Essential	Community Requests	1EI1	39.6%	Vibrio cholerae

IDP02432 (show subtarget assignments)	1	soluble	No	GBAA3687	47528971		acetyl-CoA acetyltransferase [Bacillus a...	363	Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...	Phase 3: June 2008	4DD5	39.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP04134 (show subtarget assignments)	1	expressed	No	FTT0666c	56707787		methylpurine-DNA glycosylase family prot...	193	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BNK	39.7%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02614 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1821	16803861		hypothetical protein lmo1821 [Listeria m...	252	Known virulence-Enzyme ; PMID:15813732	Phase 3: June 2008	2PK0	39.7%	Listeria monocytogenes	Protein fate	Protein modification and repair

IDP05638 (show subtarget assignments)	1	cloned	No	CD2546	126700163		endoglucanase (cellulase) [Clostridium d...	340	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3AMC	39.7%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02294 (show subtarget assignments)	1	cloned	No	FTT0483c	56707625		hypothetical protein FTT0483c [Francisel...	295	Drug Target	Phase 3: June 2008	2YKR	39.7%	Francisella tularensis	Unknown function	General

IDP04155 (show subtarget assignments)	1	cloned	No	VC0547	9654975		aspartokinase, alpha and beta subunits [...	395	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3L76	39.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP91632 (show subtarget assignments)	8	purified	No	BAB35248	13361290	ECs1825	bfpT-regulated chaperone-like protein [E...	196	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LW8	39.8%	Escherichia coli

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP91186 (show subtarget assignments)	1	in_crystallization_trials	No	CAA37605	47078		unnamed protein product [Streptomyces gr...	272	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ND4	39.8%	Streptomyces griseus

IDP00430 (show subtarget assignments)	1	purified	No	YPO2960	16123142	sfuC	iron(III)-transport ATP-binding protein ...	349	Virulence Associated Factor	Phase 2: March 2008	3FVQ	39.8%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP90639 (show subtarget assignments)	8	cloned	No	Cj0771c	15792109		lipoprotein, NLPA family [Campylobacter ...	256	Predicted Essential	Community Requests	3TQW	39.8%	Campylobacter jejuni

IDP05231 (show subtarget assignments)	1	purified	No	lmo1388	16803428	tcsA	CD4+ T cell-stimulating antigen, lipopro...	346	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	39.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP02032 (show subtarget assignments)	1	expressed	No	YPO0013	16120366	mobA	molybdopterin-guanine dinucleotide biosy...	213	Involved in virulence; Drug target functions	Phase 3: June 2008	1E5K	39.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP05568 (show subtarget assignments)	1	cloned	No	S4492	30043719	valS	valine tRNA synthetase [Shigella flexner...	951	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	39.9%	Shigella flexneri	Protein synthesis: tRNA aminoacylation

IDP92055 (show subtarget assignments)	8	selected	No	TGME49_059570	237831707		tRNA-specific adenosine deaminase, putat...	178	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3DH1	39.9%	Toxoplasma gondii

IDP90925 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0048	16120401	dfp	phosphopantothenoylcysteine synthase/dec...	405	Predicted Essential	Community Requests	1U7U	40%	Yersinia pestis

IDP05758 (show subtarget assignments)	1	cloned	No	lmo1552	16803592	valS	valyl-tRNA synthetase [Listeria monocyto...	883	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	40%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP02090 (show subtarget assignments)	1	cloned	No	STM3577	16766863	tcp	methyl-accepting transmembrane citrate/p...	547	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	40%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP04607 (show subtarget assignments)	1	cloned	No	BAS3700	49186699		ribonuclease III [Bacillus anthracis str...	245	Proposed to be essential proteins	Phase 4: April 2009	1O0W	40%	Bacillus anthracis

IDP04623 (show subtarget assignments)	1	expressed	No	BAS4760	49187751		glucose-1-phosphate adenylyltransferase ...	376	Proposed to be essential proteins	Phase 4: April 2009	3BRK	40%	Bacillus anthracis

IDP90991 (show subtarget assignments)	8	cloned	No	y1282	22125182		formate acetyltransferase [Yersinia pest...	150	other biological interest / stress-response protein replacind PflA in PflA/PflB complex	Community Requests	1CM5	40%	Yersinia pestis

IDP90741 (show subtarget assignments)	8	soluble	No	Cj0802	15792140	cysS	cysteinyl-tRNA synthetase [Campylobacter...	462	Predicted Essential	Community Requests	3TQO	40%	Campylobacter jejuni

IDP01327 (show subtarget assignments)	1	purified	No	VC0418	15640445	maf	Maf-like protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	40%	Vibrio cholerae	Cellular processes	Cell division

IDP02636 (show subtarget assignments)	1	expressed	No	YPO3722	16123860	metH	B12-dependent methionine synthase [Yersi...	1231	CD; Drug target functions	Phase 3: June 2008	1K7Y	40.1%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP90162 (show subtarget assignments)	8	purified	No	CD1833	123174272		3-dehydroquinate synthase	354	Potential drug target. Shikimate pathway enzyme	Community Requests	3OKF	40.1%	Clostridium difficile

IDP90582
(show subtarget assignments)

8

soluble

No

Cj1686c

15792989

topA

DNA topoisomerase I [Campylobacter jejun...

700

Predicted Essential

Community Requests

2GAI

38.6%

Campylobacter jejuni

IDP91941
(show subtarget assignments)

8

selected

No

SpneCM_010100000177

298254016

ABC transporter, ATP-binding/permease pr...

588

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QF4

38.6%

Streptococcus pneumoniae

IDP90161
(show subtarget assignments)

8

purified

No

CD1835

123174273

Chorismate synthase (5-enolpyruvylshikim...

359

Potential drug target. Shikimate pathway enzyme

Community Requests

1UM0

38.7%

Clostridium difficile

IDP05147
(show subtarget assignments)

1

cloned

No

BAS4903

49187891

-

methionyl-tRNA synthetase [Bacillus anth...

544

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RQG

38.7%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP01018
(show subtarget assignments)

1

expressed

No

STM2894

16766200

invC

ATP synthase SpaL

431

Conserved Gene / Pathway

Phase 2: March 2008

2OBL

38.7%

Salmonella enterica

Transport and binding proteins

Other

IDP00979
(show subtarget assignments)

1

purified

No

STM1953

16765291

yedO

D-cysteine desulfhydrase

328

Conserved Gene / Pathway

Phase 2: March 2008

1J0A

38.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02645
(show subtarget assignments)

1

soluble

No

STM1749

16765093

adhE

bifunctional acetaldehyde-CoA/alcohol de...

892

Conserved; Essential; Drug target functions

Phase 3: June 2008

3MY7

38.7%

Salmonella enterica

Energy metabolism

Fermentation

IDP01902
(show subtarget assignments)

1

soluble

No

STM0878

16764240

potG

putrescine transporter ATP-binding subun...

377

Conserved; Drug target functions

Phase 3: June 2008

1V43

38.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP04377
(show subtarget assignments)

1

soluble

No

CPF_2652

110798678

putative maltose/maltodextrin ABC transp...

408

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1URG

38.7%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01341
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0687

15601444

fbpC

ferric transporter ATP-binding subunit

351

Conserved Gene / Pathway

Phase 2: March 2008

1V43

38.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP92565
(show subtarget assignments)

8

selected

No

AAA66406

807601

nonstructural protein 1, partial [Dengue...

886

potential drug target / Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...

Community Requests

2WZQ

38.7%

Dengue virus

IDP92128
(show subtarget assignments)

8

selected

No

TGME49_082200

237844257

clpB protein, putative [Toxoplasma gondi...

970

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QVR

38.7%

Toxoplasma gondii

IDP90658
(show subtarget assignments)

8

cloned

No

VC2503

15642499

valS

valyl-tRNA synthetase [Vibrio cholerae O...

953

Predicted Essential

Community Requests

1GAX

38.8%

Vibrio cholerae

IDP90605
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1271c

15792595

tyrS

tyrosyl-tRNA synthetase [Campylobacter j...

401

Predicted Essential

Community Requests

1H3E

38.8%

Campylobacter jejuni

IDP02007
(show subtarget assignments)

1

in_crystallization_trials

No

STM2330

16765657

lrhA

NADH dehydrogenase transcriptional repre...

312

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3ONM

38.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP91061
(show subtarget assignments)

8

purified

No

YPO3532

16123678

fklB

FKBP-type peptidyl-prolyl cis-trans isom...

206

virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...

Community Requests

1FD9

38.8%

Yersinia pestis

IDP90761
(show subtarget assignments)

8

cloned

No

Cj1061c

15792388

ileS

isoleucyl-tRNA synthetase [Campylobacter...

917

Predicted Essential

Community Requests

1FFY

38.8%

Campylobacter jejuni

IDP00683
(show subtarget assignments)

1

purified

No

SACOL1795

57286229

pepA1

glutamyl aminopeptidase

358

Drug Target Function

Phase 2: March 2008

3KL9

38.8%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90696
(show subtarget assignments)

8

in_crystallization_trials

No

YPO1022

16121323

argA

N-acetylglutamate synthase [Yersinia pes...

441

Predicted Essential

Community Requests

2R8V

38.8%

Yersinia pestis

IDP00635
(show subtarget assignments)

1

cloned

No

SACOL2270

57286396

modC

molybdenum ABC transporter, ATP-binding ...

201

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

38.8%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP02459
(show subtarget assignments)

1

soluble

No

lmo2067

16804106

hypothetical protein lmo2067 [Listeria m...

325

Known virulence-Bile resistance; PMID:15664931

Phase 3: June 2008

2BJF

38.8%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP05412
(show subtarget assignments)

1

soluble

No

BA_3584

30258112

putative microbial collagenase [Bacillus...

971

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Y3U

38.9%

Bacillus anthracis

Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05743
(show subtarget assignments)

1

cloned

No

CD2653

126700267

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

451

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3LK7

38.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90662
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1288c

15792611

gltX

glutamyl-tRNA synthetase [Campylobacter ...

463

Predicted Essential

Community Requests

2CFO

38.9%

Campylobacter jejuni

IDP02462
(show subtarget assignments)

1

expressed

No

FTT1467c

56708507

nadB

L-aspartate oxidase [Francisella tularen...

495

Conserved; Drug target functions

Phase 3: June 2008

1CHU

38.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP04173
(show subtarget assignments)

1

expressed

No

VC2490

15642486

2-isopropylmalate synthase [Vibrio chole...

516

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

39%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP90754
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0498

15791862

trpC

indole-3-glycerol phosphate synthase [Ca...

258

Predicted Essential

Community Requests

3TSM

39%

Campylobacter jejuni

IDP91787
(show subtarget assignments)

8

in_crystallization_trials

No

AAA24786

148325

vanC

D-alanine-D-alanine ligase-related prote...

343

drug resistance / D-Ala:D-Ser ligase

Community Requests

1E4E

39%

Enterococcus gallinarum

IDP00705
(show subtarget assignments)

1

cloned

No

SACOL0306

57285419

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

39%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP91332
(show subtarget assignments)

8

purified

No

VV2_0201

27366656

DNA-binding transcriptional regulator Fr...

326

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3O74

39%

Vibrio vulnificus

IDP90766
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0765c

15792103

hisS

histidyl-tRNA synthetase [Campylobacter ...

408

Predicted Essential

Community Requests

4E51

39%

Campylobacter jejuni

IDP90706
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1048c

15792375

dapE

succinyl-diaminopimelate desuccinylase [...

365

Predicted Essential

Community Requests

1VGY

39%

Campylobacter jejuni

IDP90623
(show subtarget assignments)

8

purified

No

Cj1177c

15792501

gmk

guanylate kinase [Campylobacter jejuni s...

207

Predicted Essential

Community Requests

1S96

39.1%

Campylobacter jejuni

IDP91698
(show subtarget assignments)

8

selected

No

NP_002511

10835063

NPM1

nucleophosmin isoform 1 [Homo sapiens]

294

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2P1B

39.1%

Homo sapiens

IDP00917
(show subtarget assignments)

1

cloned

No

STM0355

16763735

putative copper chaperone

64

Conserved Gene / Pathway

Phase 2: March 2008

2K2P

39.1%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP01662
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2583

16804621

hypothetical protein lmo2583 [Listeria m...

225

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2OQR

39.1%

Listeria monocytogenes

Regulatory functions

Other

IDP90277
(show subtarget assignments)

8

soluble

No

TGME49_059690

211962827

orotidine-monophosphate-decarboxylase, p...

320

The orotidine monophosphate decarboxylase (TgODCase) is the last step in de novo...

Community Requests

3QW3

39.1%

Toxoplasma gondii

IDP05020
(show subtarget assignments)

1

soluble

No

CD1027

126698611

potD

spermidine/putrescine ABC transporter,su...

350

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EQB

39.1%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP91899
(show subtarget assignments)

8

selected

No

SpneCM_010100002520

298254473

ABC transporter, ATP-binding/permease pr...

564

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QF4

39.1%

Streptococcus pneumoniae

IDP91623
(show subtarget assignments)

8

expressed

No

BAB35652

13361695

ECs2229

hypothetical protein [Escherichia coli O...

169

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

39.1%

Escherichia coli

IDP05269
(show subtarget assignments)

1

soluble

No

lmo0517

16802560

-

hypothetical protein lmo0517 [Listeria m...

271

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3R7A

39.1%

Listeria monocytogenes

Energy metabolism: Glycolysis/gluconeogenesis

IDP02320
(show subtarget assignments)

1

purified

No

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01913
(show subtarget assignments)

1

cloned

No

GBAA1426

47526698

hisD

histidinol dehydrogenase [Bacillus anthr...

429

Conserved; Drug target functions

Phase 3: June 2008

1K75

39.2%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02563
(show subtarget assignments)

1

cloned

No

GBAA3299

47528584

collagenase, putative [Bacillus anthraci...

960

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04026
(show subtarget assignments)

1

expressed

No

FTT0456c

56707598

hypothetical protein FTT_0456c [Francise...

97

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YHD

39.2%

Francisella tularensis

IDP04503
(show subtarget assignments)

1

cloned

No

VC2289

15642287

thiamin biosynthesis lipoprotein ApbE [V...

367

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3PND

39.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP01498
(show subtarget assignments)

1

expressed

No

VCA0862

15601617

long-chain fatty acid transport protein ...

412

Conserved Gene / Pathway

Phase 2: March 2008

1T16

39.2%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01430
(show subtarget assignments)

1

in_crystallization_trials

No

VC1863

15641865

amino acid ABC transporter, periplasmic ...

260

Conserved Gene / Pathway

Phase 2: March 2008

1LAF

39.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91082
(show subtarget assignments)

8

cloned

No

CPF_1776

110800219

ABC transporter, permease/ATP-binding pr...

589

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

39.2%

Clostridium perfringens

IDP02421
(show subtarget assignments)

1

purified

No

Cj0606

15791966

macrolide-specific efflux protein macA [...

390

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

4DK0

39.2%

Campylobacter jejuni

Transport and binding proteins

Other

IDP00611
(show subtarget assignments)

1

crystallized

No

SACOL1952

57286299

ferritins family protein

166

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

39.2%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP90570
(show subtarget assignments)

8

in_pdb
4EHI

No

Cj0953c

15792282

purH

bifunctional phosphoribosylaminoimidazol...

510

Predicted Essential

Community Requests

3ZZM

39.2%

Campylobacter jejuni

IDP02298
(show subtarget assignments)

1

soluble

No

GBAA0555

47525828

collagenase,putative [Bacillus anthracis...

965

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00829
(show subtarget assignments)

1

purified

No

SACOL2515

57285199

gntK

gluconokinase

517

Drug Target Function

Phase 2: March 2008

3GBT

39.3%

Staphylococcus aureus

Energy metabolism

Sugars

IDP00349
(show subtarget assignments)

1

expressed

No

lmo1632

16803672

trpG

hypothetical protein lmo1632

201

Predicted involvement in glycosyl group metabolism; Drug Target Homologs

Phase 2: March 2008

1I1Q

39.3%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP02738
(show subtarget assignments)

1

cloned

No

FTT1310c

56708367

hflB

ATP-dependent metalloprotease [Francisel...

638

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2DHR

39.3%

Francisella tularensis

N/A

IDP91081
(show subtarget assignments)

8

cloned

No

CD2817

126700433

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

39.4%

Clostridium difficile

IDP01922
(show subtarget assignments)

1

expressed

No

GBAA1441

47526716

sat

sulfate adenylyltransferase [Bacillus an...

378

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1V47

39.4%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP91240
(show subtarget assignments)

8

cloned

No

HP1280

0

335

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

39.4%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP01733
(show subtarget assignments)

1

cloned

No

FTT0811c

56707922

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

371

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1F0K

39.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01671
(show subtarget assignments)

1

cloned

No

YPO3012

16123191

cysA

sulfate/thiosulfate transporter subunit ...

363

Conserved; CD; Drug target functions

Phase 3: June 2008

1Z47

39.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00015
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4048

47605856

UDP-N-acetylenolpyruvoylglucosamine redu...

301

Drug Target Homolog

Phase 1: October 2007

1HSK

39.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02027
(show subtarget assignments)

1

soluble

No

CBU_0599

29541200

cysQ-1

3'(2'),5'-bisphosphate nucleotidase [Cox...

271

Conserved; Drug target functions

Phase 3: June 2008

3B8B

39.5%

Coxiella burnetii

Central intermediary metabolism

Sulfur metabolism

IDP91766
(show subtarget assignments)

8

expressed

No

b3441

16131313

yhhY

predicted acetyltransferase [Escherichia...

162

drug resistance; innate immunity / E.coli YhhY (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...

Community Requests

2VI7

39.5%

Escherichia coli

IDP00108
(show subtarget assignments)

1

purified

No

NT01SF4751

30043076

fdhE

FdhE protein

309

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FIY

39.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP05544
(show subtarget assignments)

1

purified

No

Cj1409

6968828

acpS

putative Ni/Fe-hydrogenase small subunit...

115

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3HYK

39.5%

Campylobacter jejuni

Fatty acid and phospholipid metabolism: Biosynthesis

IDP01639
(show subtarget assignments)

1

cloned

No

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01403
(show subtarget assignments)

1

in_crystallization_trials

No

VC0854

15640870

heat shock protein GrpE

200

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

39.5%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP91744
(show subtarget assignments)

8

selected

No

Q76ZW2_VACCW

0

190

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1OYI

39.5%

Vaccinia virus

IDP02363
(show subtarget assignments)

1

purified

No

FTT1366c

56708419

pyk

pyruvate kinase [Francisella tularensis ...

478

Conserved; Drug target functions

Phase 3: June 2008

1E0U

39.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP91283
(show subtarget assignments)

8

cloned

No

NT05BA5557

49182237

single-stranded DNA-binding protein [Bac...

172

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3VDY

39.5%

Bacillus anthracis

Mobile and extrachromosomal element functions: Prophage functions

IDP00547
(show subtarget assignments)

1

expressed

No

YPO3813

16123947

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

39.6%

Yersinia pestis

Cellular processes

Cell division

IDP01809
(show subtarget assignments)

1

purified

No

FTT0258

56707414

carboxylesterase/phospholipase family pr...

222

Drug Target

Phase 3: June 2008

1FJ2

39.6%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP02501
(show subtarget assignments)

1

cloned

No

GBAA1250

47526516

trpD

anthranilate phosphoribosyltransferase [...

341

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VQU

39.6%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP90603
(show subtarget assignments)

8

selected

No

VC0015

15640047

gyrB

DNA gyrase subunit B [Vibrio cholerae O1...

805

Predicted Essential

Community Requests

1EI1

39.6%

Vibrio cholerae

IDP02432
(show subtarget assignments)

1

soluble

No

GBAA3687

47528971

acetyl-CoA acetyltransferase [Bacillus a...

363

Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...

Phase 3: June 2008

4DD5

39.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP04134
(show subtarget assignments)

1

expressed

No

FTT0666c

56707787

methylpurine-DNA glycosylase family prot...

193

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BNK

39.7%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02614
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1821

16803861

hypothetical protein lmo1821 [Listeria m...

252

Known virulence-Enzyme ; PMID:15813732

Phase 3: June 2008

2PK0

39.7%

Listeria monocytogenes

Protein fate

Protein modification and repair

IDP05638
(show subtarget assignments)

1

cloned

No

CD2546

126700163

endoglucanase (cellulase) [Clostridium d...

340

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3AMC

39.7%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02294
(show subtarget assignments)

1

cloned

No

FTT0483c

56707625

hypothetical protein FTT0483c [Francisel...

295

Drug Target

Phase 3: June 2008

2YKR

39.7%

Francisella tularensis

Unknown function

General

IDP04155
(show subtarget assignments)

1

cloned

No

VC0547

9654975

aspartokinase, alpha and beta subunits [...

395

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3L76

39.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP91632
(show subtarget assignments)

8

purified

No

BAB35248

13361290

ECs1825

bfpT-regulated chaperone-like protein [E...

196

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LW8

39.8%

Escherichia coli

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP91186
(show subtarget assignments)

1

in_crystallization_trials

No

CAA37605

47078

unnamed protein product [Streptomyces gr...

272

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ND4

39.8%

Streptomyces griseus

IDP00430
(show subtarget assignments)

1

purified

No

YPO2960

16123142

sfuC

iron(III)-transport ATP-binding protein ...

349

Virulence Associated Factor

Phase 2: March 2008

3FVQ

39.8%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP90639
(show subtarget assignments)

8

cloned

No

Cj0771c

15792109

lipoprotein, NLPA family [Campylobacter ...

256

Predicted Essential

Community Requests

3TQW

39.8%

Campylobacter jejuni

IDP05231
(show subtarget assignments)

1

purified

No

lmo1388

16803428

tcsA

CD4+ T cell-stimulating antigen, lipopro...

346

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

39.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP02032
(show subtarget assignments)

1

expressed

No

YPO0013

16120366

mobA

molybdopterin-guanine dinucleotide biosy...

213

Involved in virulence; Drug target functions

Phase 3: June 2008

1E5K

39.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP05568
(show subtarget assignments)

1

cloned

No

S4492

30043719

valS

valine tRNA synthetase [Shigella flexner...

951

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

39.9%

Shigella flexneri

Protein synthesis: tRNA aminoacylation

IDP92055
(show subtarget assignments)

8

selected

No

TGME49_059570

237831707

tRNA-specific adenosine deaminase, putat...

178

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3DH1

39.9%

Toxoplasma gondii

IDP90925
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0048

16120401

dfp

phosphopantothenoylcysteine synthase/dec...

405

Predicted Essential

Community Requests

1U7U

40%

Yersinia pestis

IDP05758
(show subtarget assignments)

1

cloned

No

lmo1552

16803592

valS

valyl-tRNA synthetase [Listeria monocyto...

883

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

40%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP02090
(show subtarget assignments)

1

cloned

No

STM3577

16766863

tcp

methyl-accepting transmembrane citrate/p...

547

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

40%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP04607
(show subtarget assignments)

1

cloned

No

BAS3700

49186699

ribonuclease III [Bacillus anthracis str...

245

Proposed to be essential proteins

Phase 4: April 2009

1O0W

40%

Bacillus anthracis

IDP04623
(show subtarget assignments)

1

expressed

No

BAS4760

49187751

glucose-1-phosphate adenylyltransferase ...

376

Proposed to be essential proteins

Phase 4: April 2009

3BRK

40%

Bacillus anthracis

IDP90991
(show subtarget assignments)

8

cloned

No

y1282

22125182

formate acetyltransferase [Yersinia pest...

150

other biological interest / stress-response protein replacind PflA in PflA/PflB complex

Community Requests

1CM5

40%

Yersinia pestis

IDP90741
(show subtarget assignments)

8

soluble

No

Cj0802

15792140

cysS

cysteinyl-tRNA synthetase [Campylobacter...

462

Predicted Essential

Community Requests

3TQO

40%

Campylobacter jejuni

IDP01327
(show subtarget assignments)

1

purified

No

VC0418

15640445

maf

Maf-like protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

40%

Vibrio cholerae

Cellular processes

Cell division

IDP02636
(show subtarget assignments)

1

expressed

No

YPO3722

16123860

metH

B12-dependent methionine synthase [Yersi...

1231

CD; Drug target functions

Phase 3: June 2008

1K7Y

40.1%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP90162
(show subtarget assignments)

8

purified

No

CD1833

123174272

3-dehydroquinate synthase

354

Potential drug target. Shikimate pathway enzyme

Community Requests

3OKF

40.1%

Clostridium difficile