Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02330 (show subtarget assignments)	1	cloned	No	GBAA1419	47526691	ilvC-1	ketol-acid reductoisomerase [Bacillus an...	336	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	55.7%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP01153 (show subtarget assignments)	1	cloned	No	BA_5712	30260159		yycI protein	280	Conserved Gene / Pathway	Phase 2: March 2008	2O3O	28.2%	Bacillus anthracis	Cellular processes	Cell division

IDP00606 (show subtarget assignments)	1	cloned	No	SACOL1933	57286280		ThiJ/PfpI family protein	171	Drug Target Function	Phase 2: March 2008	1OI4	48.8%	Staphylococcus aureus	Unknown function	General

IDP04405 (show subtarget assignments)	1	cloned	No	CPF_2987	110799346		stage 0 sporulation protein J [Clostridi...	286	conserved gene; putative drug target function;	Phase 4: April 2009	1VZ0	33.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05200 (show subtarget assignments)	1	cloned	No	lmo2714	16804751	-	pepdidoglycan bound protein [Listeria mo...	315	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Regulatory functions: Other

IDP05201 (show subtarget assignments)	1	cloned	No	CD1698	126699304	ribA	riboflavin biosynthesis protein [Clostri...	408	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3MGZ	25.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP02822 (show subtarget assignments)	1	cloned	No	GBAA4819	47778330	infC	translation initiation factor IF-3 [Baci...	186	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TIG	40.9%	Bacillus anthracis	Protein synthesis	Translation factors

IDP05202 (show subtarget assignments)	1	cloned	No	CD1700	126699306	ribD	riboflavin biosynthesis protein [Clostri...	367	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HXV	41.4%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP02338 (show subtarget assignments)	1	cloned	No	GBAA1456	47526731		sensor histidine kinase [Bacillus anthra...	351	Conserved; Drug target functions	Phase 3: June 2008	3EHH	14.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP90435 (show subtarget assignments)	8	cloned	No	CT_871	3329346	pmpG	Putative Outer Membrane Protein G [Chlam...	1013	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00033 (show subtarget assignments)	1	cloned	No	BA_1295	30255240		immune inhibitor A metalloprotease	795	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02341 (show subtarget assignments)	1	cloned	No	FTT1313c	56708370	greA	transcriptional elongation factor [Franc...	160	Conserved; Drug target functions	Phase 3: June 2008	1GRJ	63.1%	Francisella tularensis	Regulatory functions	Other

IDP04020 (show subtarget assignments)	1	cloned	No	CPF_2112	110800515		cell division protein FtsQ [Clostridium ...	248	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP05207 (show subtarget assignments)	1	cloned	No	CD2365	126699980		putative sulfonate ABC transporter,solut...	363	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QSL	20.4%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP02344 (show subtarget assignments)	1	cloned	No	FTT0356	56707508	htpG	heat shock protein 90 [Francisella tular...	628	Conserved; Drug target functions	Phase 3: June 2008	2IOP	52.4%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein folding and stabilization

IDP04445 (show subtarget assignments)	1	cloned	No	YPO0619	115346424		putative HlyD family secretion protein [...	349	conserved gene; putative drug target function;	Phase 4: April 2009	4DK1	17.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05194 (show subtarget assignments)	1	cloned	No	CD0843	126698423		putative glycosyl transferase [Clostridi...	411	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2JJM	19.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01166 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0190	47566502		hypothetical protein GBAA_pXO1_0190	410	Virulence Associated Factor	Phase 2: March 2008			Bacillus anthracis

IDP00610 (show subtarget assignments)	1	cloned	No	SACOL1437	57286088		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	75.8%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP04412 (show subtarget assignments)	1	cloned	No	CPF_0435	110799959		putative lipoprotein [Clostridium perfri...	431	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04413 (show subtarget assignments)	1	cloned	No	VC2373	15642370		glutamate synthase, large subunit [Vibri...	1530	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1LLW	44.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP02351 (show subtarget assignments)	1	cloned	No	FTT1112c	56708190	rpoH	RNA polymerase factor sigma-32 [Francise...	292	Drug Target	Phase 3: June 2008	1IW7	25%	Francisella tularensis	Cellular processesTranscription	Adaptations to atypical conditionsTranscription factors

IDP05196 (show subtarget assignments)	1	cloned	No	CD0961	126698545		putative phage cell wall hydrolase [Clos...	656	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3H41	8.1%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP01169 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0146	47566458	atxA	transcriptional activator atxa, (pxo1-11...	475	Virulence Associated Factor	Phase 2: March 2008	3SQN	20.4%	Bacillus anthracis

IDP02354 (show subtarget assignments)	1	cloned	No	Cj0887c	15792217	flaD	flagellar hook-associated protein [Campy...	750	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	13.9%	Campylobacter jejuni	Cell envelope	Other

IDP01170 (show subtarget assignments)	1	cloned	No	BA_0165	30253674		prolyl oligopeptidase family protein, pu...	654	Drug Target Function	Phase 2: March 2008	1Z68	11.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02356 (show subtarget assignments)	1	cloned	No	FTT1296	56708355	ubiE	menaquinone biosynthesis methyltransfera...	250	Conserved; Drug target functions	Phase 3: June 2008	2AVN	20%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02813 (show subtarget assignments)	1	cloned	No	Cj0367c	15791734		RND efflux system, membrane fusion prote...	367	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	1T5E	29.2%	Campylobacter jejuni	Regulatory functions	Other

IDP02814 (show subtarget assignments)	1	cloned	No	FTT0709	56707828	eno	enolase (2-phosphoglycerate dehydratase)...	456	Conserved; Drug target functions	Phase 3: June 2008	1IYX	60.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP04004 (show subtarget assignments)	1	cloned	No	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP01173 (show subtarget assignments)	1	cloned	No	BA_1587	30255887		thermostable carboxypeptidase 1	505	Drug Target Function	Phase 2: March 2008	3HQ2	60.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04420 (show subtarget assignments)	1	cloned	No	GBAA3308	47528594	sdhB-1	l-serine dehydratase, iron-sulfur-depend...	232	virulence factor; putative drug target function;	Phase 4: April 2009	2IQQ	15.5%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02362 (show subtarget assignments)	1	cloned	No	GBAA1923	47777980	ldh	L-lactate dehydrogenase [Bacillus anthra...	314	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PQD	64.6%	Bacillus anthracis	Energy metabolism	Anaerobic

IDP90573 (show subtarget assignments)	8	cloned	No	Cj0479	15791843	rpoC	DNA-directed RNA polymerase beta' chain ...	1517	Predicted Essential	Community Requests	3IYD	46.1%	Campylobacter jejuni

IDP02364 (show subtarget assignments)	1	cloned	No	Cj0365c	15791732		putative outer membrane channel protein ...	492	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	3PIK	24.8%	Campylobacter jejuni	Cellular processes	Toxin production and resistance

IDP00305 (show subtarget assignments)	1	cloned	No	CBU_0118	29653476	pbpB	penicillin-binding protein 3	548	Drug Target Function	Phase 2: March 2008	3OC2	45.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04003 (show subtarget assignments)	1	cloned	No	BAS0126	49183160		50S ribosomal protein L18 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1OVY	75.8%	Bacillus anthracis

IDP90590 (show subtarget assignments)	8	cloned	No	Cj0770c	15792108		lipoprotein, NLPA family [Campylobacter ...	258	Predicted Essential	Community Requests	1P99	35.7%	Campylobacter jejuni

IDP04403 (show subtarget assignments)	1	cloned	No	CPF_0630	110801303		spore germination protein [Clostridium p...	374	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N54	17.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02317 (show subtarget assignments)	1	cloned	No	FTT0256c	56707412		lipopolysaccharide protein [Francisella ...	322	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00282 (show subtarget assignments)	1	cloned	No	AAX48017_2243-2483	61652905	N/A	NS4B	241	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP04402 (show subtarget assignments)	1	cloned	No	VC2254	15642252		1-deoxy-D-xylulose 5-phosphate reductois...	402	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K5H	60.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00616 (show subtarget assignments)	1	cloned	No	SACOL1586	57286108		hypothetical protein SACOL1586	94	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	0	0

IDP04019 (show subtarget assignments)	1	cloned	No	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009	3TUF	24.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01180 (show subtarget assignments)	1	cloned	No	BA_0049	46396353		Ribose-phosphate pyrophosphokinase (RPPK...	317	Conserved Gene / Pathway	Phase 2: March 2008	1DKR	85.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04008 (show subtarget assignments)	1	cloned	No	YPO0906	218928079	gcsH	glycine cleavage system protein H [Yersi...	128	conserved gene; putative drug target function;	Phase 4: April 2009	3A7A	75%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02376 (show subtarget assignments)	1	cloned	No	FTT0451	56707593	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	416	Conserved; Drug target functions	Phase 3: June 2008	1E0D	31.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04006 (show subtarget assignments)	1	cloned	No	CPF_1351	110800739		putative lipoprotein [Clostridium perfri...	264	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP02378 (show subtarget assignments)	1	cloned	No	CBU_1675	29542234	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	280	Conserved; Drug target functions	Phase 3: June 2008	3T4C	62.5%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90640 (show subtarget assignments)	8	cloned	No	Cj0798c	15792136	ddl	D-alanyl-alanine synthetase A [Campyloba...	346	Predicted Essential	Community Requests	2PVP	54%	Campylobacter jejuni

IDP04010 (show subtarget assignments)	1	cloned	No	CPF_2393	110798628	minD	septum site-determining protein MinD [Cl...	265	conserved gene; putative drug target function;	Phase 4: April 2009	3Q9L	43.4%	Clostridium perfringens	Cellular processes	Cell division

IDP04012 (show subtarget assignments)	1	cloned	No	CPF_2355	110800506	virJ	sensor histidine kinase [Clostridium per...	482	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	15.4%	Clostridium perfringens	Cellular processes	Pathogenesis

IDP02382 (show subtarget assignments)	1	cloned	No	lmo0320	16802365		hypothetical protein lmo0320 [Listeria m...	399	Known virulence-Invasion; PMID:16015374	Phase 3: June 2008			Listeria monocytogenes	Cell envelope	Other

IDP04009 (show subtarget assignments)	1	cloned	No	VC2277	15642275		xanthine-guanine phosphoribosyltransfera...	154	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A95	68.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01185 (show subtarget assignments)	1	cloned	No	BA_0280	30253775		glycosyl transferase, group 1 family pro...	443	Drug Target Function	Phase 2: March 2008	2JJM	13.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02385 (show subtarget assignments)	1	cloned	No	Cj0755	15792094	cfrA	putative iron uptake protein [Campylobac...	696	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	2HDF	29.8%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04409 (show subtarget assignments)	1	cloned	No	YPO3965	115349572		putative hybrid two-component system reg...	851	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	9.3%	Yersinia pestis	Regulatory functions	Other

IDP00619 (show subtarget assignments)	1	cloned	No	SACOL2464	57286459		addiction module toxin, Txe/YoeB family ...	88	Virulence Associated Factor	Phase 2: March 2008			Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00620 (show subtarget assignments)	1	cloned	No	SACOL0937	57285812	dltC	D-alanine--poly(phosphoribitol) ligase s...	78	Conserved Gene / Pathway	Phase 2: March 2008	1DV5	41%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02389 (show subtarget assignments)	1	cloned	No	lmo0232	16802278	clpC	endopeptidase Clp ATP-binding chain C [L...	820	Known virulence-Invasion; PMID:11083831; Presence of Protease Motifs	Phase 3: June 2008	3PXI	72.8%	Listeria monocytogenes	Energy metabolism	ATP-proton motive force interconversion

IDP02390 (show subtarget assignments)	1	cloned	No	CBU_1718	29542276	groEL	chaperonin, 60 kDa [Coxiella burnetii RS...	552	Conserved; Drug target functions	Phase 3: June 2008	2EU1	75.5%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02391 (show subtarget assignments)	1	cloned	No	FTT0534c	56707667	nrdA	ribonucleotide-diphosphate reductase sub...	590	Drug Target	Phase 3: June 2008	2WGH	31.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP04443 (show subtarget assignments)	1	cloned	No	YPO0506	218927704	clpB	putative Clp ATPase [Yersinia pestis CO9...	867	virulence factor; putative drug target function;	Phase 4: April 2009	1QVR	36.3%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP02394 (show subtarget assignments)	1	cloned	No	YPO1633	16121901	phoQ	sensor protein PhoQ [Yersinia pestis CO9...	484	Conserved; CD; Drug target functions	Phase 3: June 2008	1ID0	20.9%	Yersinia pestis	Regulatory functions	Other

IDP01190 (show subtarget assignments)	1	cloned	No	BA_0872	30254622		N-acetylmuramoyl-L-alanine amidase, fami...	348	Drug Target Function	Phase 2: March 2008	3HMB	25.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00622 (show subtarget assignments)	1	cloned	No	SACOL1878	57284798	epiA	lantibiotic epidermin precursor EpiA	47	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP04017 (show subtarget assignments)	1	cloned	No	CPF_1035	110799411		putative lipoprotein [Clostridium perfri...	309	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP02534 (show subtarget assignments)	1	cloned	No	GBAA4614	47529912		Holliday junction resolvase-like protein...	137	Conserved;	Phase 3: June 2008	1VHX	70.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02399 (show subtarget assignments)	1	cloned	No	GBAA2559	47527848		D-alanyl-D-alanine carboxypeptidase fami...	338	Drug target motif; Drug target functions	Phase 3: June 2008	1XP4	26.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90422 (show subtarget assignments)	8	cloned	No	CT_471	3328905		hypothetical protein [Chlamydia trachoma...	200	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02401 (show subtarget assignments)	1	cloned	No	Cj0574	15791934	ilvI	acetolactate synthase 3 catalytic subuni...	566	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1JSC	40.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04439 (show subtarget assignments)	1	cloned	No	YPO0185	115346005	ssiD	putative taurine dioxygenase [Yersinia p...	282	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GQW	75.9%	Yersinia pestis	Energy metabolism	Other

IDP04440 (show subtarget assignments)	1	cloned	No	YPO0266	115346083		secretion system apparatus protein [Yers...	682	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2X49	15.4%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02315 (show subtarget assignments)	1	cloned	No	GBAA1132	47526402	aceA	isocitrate lyase [Bacillus anthracis str...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4E	71.4%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP02314 (show subtarget assignments)	1	cloned	No	GBAA0599	47525877		neutral protease [Bacillus anthracis str...	566	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1NPC	53%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02440 (show subtarget assignments)	1	cloned	No	lmo0331	16802376		hypothetical protein lmo0331 [Listeria m...	633	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	3BZ5	28.4%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP02407 (show subtarget assignments)	1	cloned	No	GBAA3988	47529279	acpP	acyl carrier protein [Bacillus anthracis...	77	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2X2B	81.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00625 (show subtarget assignments)	1	cloned	No	SACOL2404	57285135		addiction module toxin, Txe/YoeB family ...	88	Virulence Associated Factor	Phase 2: March 2008	2A6Q	51.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP02732 (show subtarget assignments)	1	cloned	No	CBU_1982	29542537	ksgA	dimethyladenosine transferase [Coxiella ...	255	Conserved; Drug target functions	Phase 3: June 2008	3TQS	100%	Coxiella burnetii	Protein synthesis	tRNA and rRNA base modification

IDP02743 (show subtarget assignments)	1	cloned	No	GBAA4383	47529678	bfmbAb	3-methyl-2-oxobutanoate dehydrogenase, b...	327	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	52.9%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP04022 (show subtarget assignments)	1	cloned	No	BAS0095	49183129		preprotein translocase subunit SecE [Bac...	59	Proposed to be essential proteins	Phase 4: April 2009	3DIN	33.9%	Bacillus anthracis

IDP00626 (show subtarget assignments)	1	cloned	No	SACOL2506	57285191	sarT	staphylococcal accessory regulator T	118	Conserved Gene / Pathway	Phase 2: March 2008	2FNP	33.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP02413 (show subtarget assignments)	1	cloned	No	YPO3568	16123712	degS	serine endoprotease [Yersinia pestis CO9...	362	Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...	Phase 3: June 2008	1SOT	63%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01200 (show subtarget assignments)	1	cloned	No	BA_1707	30255995		transglycosylase, SLT family	261	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04451 (show subtarget assignments)	1	cloned	No	YPO1043	218928211	ampM	methionine aminopeptidase [Yersinia pest...	263	drug target; putative drug target function;	Community Interest	1MAT	84%	Yersinia pestis	Protein fate	Protein modification and repair

IDP04030 (show subtarget assignments)	1	cloned	No	YPO2532	115348229		hypothetical protein [Yersinia pestis CO...	70	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP02417 (show subtarget assignments)	1	cloned	No	FTT0812	56707923	gcvH1	glycine cleavage system protein H [Franc...	126	Conserved; Drug target functions	Phase 3: June 2008	1ZKO	40.5%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP04032 (show subtarget assignments)	1	cloned	No	CPF_2081	110798910		stage III sporulation protein AG [Clostr...	201	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04027 (show subtarget assignments)	1	cloned	No	BAS4637	49187628		leucyl-tRNA synthetase [Bacillus anthrac...	802	Proposed to be essential proteins	Phase 4: April 2009	1H3N	45.9%	Bacillus anthracis

IDP90417 (show subtarget assignments)	8	cloned	No	CT_504	3328941		hypothetical protein [Chlamydia trachoma...	288	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02736 (show subtarget assignments)	1	cloned	No	GBAA4352	47778283	argD	acetylornithine aminotransferase [Bacill...	386	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	44%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02422 (show subtarget assignments)	1	cloned	No	YPO1666	16121930	cheA	chemotaxis protein CheA [Yersinia pestis...	723	Conserved; CD; Drug target functions	Phase 3: June 2008	1B3Q	22.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP02423 (show subtarget assignments)	1	cloned	No	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02313 (show subtarget assignments)	1	cloned	No	GBAA3973	47529263	sucD	succinyl-CoA synthetase subunit alpha [B...	300	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JKJ	62.3%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP04448 (show subtarget assignments)	1	cloned	No	YPO0810	218927990		general secretion pathway protein J [Yer...	198	putative drug target function;	Phase 4: April 2009	2RET	20.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02426 (show subtarget assignments)	1	cloned	No	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04036 (show subtarget assignments)	1	cloned	No	CPF_1970	110800938	smc	chromosome segregation protein SMC [Clos...	1185	conserved gene; putative drug target function;	Phase 4: April 2009	3AUX	8.2%	Clostridium perfringens	Cellular processes	Cell division

IDP00281 (show subtarget assignments)	1	cloned	No	AAX48017_776-1130	61652905	N/A	NS1	355	Secreted from infected cells; stimulates protective immune responses (reason for...	Phase 3: June 2008			Dengue virus	host defense modulator	N/A

IDP02812 (show subtarget assignments)	1	cloned	No	FTT1484c	56708523	aceF	dihydrolipoamide acetyltransferase [Fran...	631	Conserved; Drug target functions	Phase 3: June 2008	3DUF	26%	Francisella tularensis	Energy metabolism	Pyruvate dehydrogenase

IDP02330
(show subtarget assignments)

1

cloned

No

GBAA1419

47526691

ilvC-1

ketol-acid reductoisomerase [Bacillus an...

336

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

55.7%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP01153
(show subtarget assignments)

1

cloned

No

BA_5712

30260159

yycI protein

280

Conserved Gene / Pathway

Phase 2: March 2008

2O3O

28.2%

Bacillus anthracis

Cellular processes

Cell division

IDP00606
(show subtarget assignments)

1

cloned

No

SACOL1933

57286280

ThiJ/PfpI family protein

171

Drug Target Function

Phase 2: March 2008

1OI4

48.8%

Staphylococcus aureus

Unknown function

General

IDP04405
(show subtarget assignments)

1

cloned

No

CPF_2987

110799346

stage 0 sporulation protein J [Clostridi...

286

conserved gene; putative drug target function;

Phase 4: April 2009

1VZ0

33.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05200
(show subtarget assignments)

1

cloned

No

lmo2714

16804751

-

pepdidoglycan bound protein [Listeria mo...

315

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Regulatory functions: Other

IDP05201
(show subtarget assignments)

1

cloned

No

CD1698

126699304

ribA

riboflavin biosynthesis protein [Clostri...

408

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3MGZ

25.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP02822
(show subtarget assignments)

1

cloned

No

GBAA4819

47778330

infC

translation initiation factor IF-3 [Baci...

186

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TIG

40.9%

Bacillus anthracis

Protein synthesis

Translation factors

IDP05202
(show subtarget assignments)

1

cloned

No

CD1700

126699306

ribD

riboflavin biosynthesis protein [Clostri...

367

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HXV

41.4%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP02338
(show subtarget assignments)

1

cloned

No

GBAA1456

47526731

sensor histidine kinase [Bacillus anthra...

351

Conserved; Drug target functions

Phase 3: June 2008

3EHH

14.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP90435
(show subtarget assignments)

8

cloned

No

CT_871

3329346

pmpG

Putative Outer Membrane Protein G [Chlam...

1013

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00033
(show subtarget assignments)

1

cloned

No

BA_1295

30255240

immune inhibitor A metalloprotease

795

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02341
(show subtarget assignments)

1

cloned

No

FTT1313c

56708370

greA

transcriptional elongation factor [Franc...

160

Conserved; Drug target functions

Phase 3: June 2008

1GRJ

63.1%

Francisella tularensis

Regulatory functions

Other

IDP04020
(show subtarget assignments)

1

cloned

No

CPF_2112

110800515

cell division protein FtsQ [Clostridium ...

248

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP05207
(show subtarget assignments)

1

cloned

No

CD2365

126699980

putative sulfonate ABC transporter,solut...

363

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QSL

20.4%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP02344
(show subtarget assignments)

1

cloned

No

FTT0356

56707508

htpG

heat shock protein 90 [Francisella tular...

628

Conserved; Drug target functions

Phase 3: June 2008

2IOP

52.4%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein folding and stabilization

IDP04445
(show subtarget assignments)

1

cloned

No

YPO0619

115346424

putative HlyD family secretion protein [...

349

conserved gene; putative drug target function;

Phase 4: April 2009

4DK1

17.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05194
(show subtarget assignments)

1

cloned

No

CD0843

126698423

putative glycosyl transferase [Clostridi...

411

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2JJM

19.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01166
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0190

47566502

hypothetical protein GBAA_pXO1_0190

410

Virulence Associated Factor

Phase 2: March 2008

Bacillus anthracis

IDP00610
(show subtarget assignments)

1

cloned

No

SACOL1437

57286088

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

75.8%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP04412
(show subtarget assignments)

1

cloned

No

CPF_0435

110799959

putative lipoprotein [Clostridium perfri...

431

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04413
(show subtarget assignments)

1

cloned

No

VC2373

15642370

glutamate synthase, large subunit [Vibri...

1530

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1LLW

44.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family

IDP02351
(show subtarget assignments)

1

cloned

No

FTT1112c

56708190

rpoH

RNA polymerase factor sigma-32 [Francise...

292

Drug Target

Phase 3: June 2008

1IW7

25%

Francisella tularensis

Cellular processesTranscription

Adaptations to atypical conditionsTranscription factors

IDP05196
(show subtarget assignments)

1

cloned

No

CD0961

126698545

putative phage cell wall hydrolase [Clos...

656

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3H41

8.1%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP01169
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0146

47566458

atxA

transcriptional activator atxa, (pxo1-11...

475

Virulence Associated Factor

Phase 2: March 2008

3SQN

20.4%

Bacillus anthracis

IDP02354
(show subtarget assignments)

1

cloned

No

Cj0887c

15792217

flaD

flagellar hook-associated protein [Campy...

750

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

13.9%

Campylobacter jejuni

Cell envelope

Other

IDP01170
(show subtarget assignments)

1

cloned

No

BA_0165

30253674

prolyl oligopeptidase family protein, pu...

654

Drug Target Function

Phase 2: March 2008

1Z68

11.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02356
(show subtarget assignments)

1

cloned

No

FTT1296

56708355

ubiE

menaquinone biosynthesis methyltransfera...

250

Conserved; Drug target functions

Phase 3: June 2008

2AVN

20%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02813
(show subtarget assignments)

1

cloned

No

Cj0367c

15791734

RND efflux system, membrane fusion prote...

367

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

1T5E

29.2%

Campylobacter jejuni

Regulatory functions

Other

IDP02814
(show subtarget assignments)

1

cloned

No

FTT0709

56707828

eno

enolase (2-phosphoglycerate dehydratase)...

456

Conserved; Drug target functions

Phase 3: June 2008

1IYX

60.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP04004
(show subtarget assignments)

1

cloned

No

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP01173
(show subtarget assignments)

1

cloned

No

BA_1587

30255887

thermostable carboxypeptidase 1

505

Drug Target Function

Phase 2: March 2008

3HQ2

60.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04420
(show subtarget assignments)

1

cloned

No

GBAA3308

47528594

sdhB-1

l-serine dehydratase, iron-sulfur-depend...

232

virulence factor; putative drug target function;

Phase 4: April 2009

2IQQ

15.5%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02362
(show subtarget assignments)

1

cloned

No

GBAA1923

47777980

ldh

L-lactate dehydrogenase [Bacillus anthra...

314

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PQD

64.6%

Bacillus anthracis

Energy metabolism

Anaerobic

IDP90573
(show subtarget assignments)

8

cloned

No

Cj0479

15791843

rpoC

DNA-directed RNA polymerase beta' chain ...

1517

Predicted Essential

Community Requests

3IYD

46.1%

Campylobacter jejuni

IDP02364
(show subtarget assignments)

1

cloned

No

Cj0365c

15791732

putative outer membrane channel protein ...

492

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

3PIK

24.8%

Campylobacter jejuni

Cellular processes

Toxin production and resistance

IDP00305
(show subtarget assignments)

1

cloned

No

CBU_0118

29653476

pbpB

penicillin-binding protein 3

548

Drug Target Function

Phase 2: March 2008

3OC2

45.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04003
(show subtarget assignments)

1

cloned

No

BAS0126

49183160

50S ribosomal protein L18 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1OVY

75.8%

Bacillus anthracis

IDP90590
(show subtarget assignments)

8

cloned

No

Cj0770c

15792108

lipoprotein, NLPA family [Campylobacter ...

258

Predicted Essential

Community Requests

1P99

35.7%

Campylobacter jejuni

IDP04403
(show subtarget assignments)

1

cloned

No

CPF_0630

110801303

spore germination protein [Clostridium p...

374

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N54

17.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02317
(show subtarget assignments)

1

cloned

No

FTT0256c

56707412

lipopolysaccharide protein [Francisella ...

322

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00282
(show subtarget assignments)

1

cloned

No

AAX48017_2243-2483

61652905

N/A

NS4B

241

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP04402
(show subtarget assignments)

1

cloned

No

VC2254

15642252

1-deoxy-D-xylulose 5-phosphate reductois...

402

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K5H

60.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00616
(show subtarget assignments)

1

cloned

No

SACOL1586

57286108

hypothetical protein SACOL1586

94

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

0

IDP04019
(show subtarget assignments)

1

cloned

No

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

3TUF

24.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01180
(show subtarget assignments)

1

cloned

No

BA_0049

46396353

Ribose-phosphate pyrophosphokinase (RPPK...

317

Conserved Gene / Pathway

Phase 2: March 2008

1DKR

85.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04008
(show subtarget assignments)

1

cloned

No

YPO0906

218928079

gcsH

glycine cleavage system protein H [Yersi...

128

conserved gene; putative drug target function;

Phase 4: April 2009

3A7A

75%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02376
(show subtarget assignments)

1

cloned

No

FTT0451

56707593

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

416

Conserved; Drug target functions

Phase 3: June 2008

1E0D

31.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04006
(show subtarget assignments)

1

cloned

No

CPF_1351

110800739

putative lipoprotein [Clostridium perfri...

264

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP02378
(show subtarget assignments)

1

cloned

No

CBU_1675

29542234

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

280

Conserved; Drug target functions

Phase 3: June 2008

3T4C

62.5%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90640
(show subtarget assignments)

8

cloned

No

Cj0798c

15792136

ddl

D-alanyl-alanine synthetase A [Campyloba...

346

Predicted Essential

Community Requests

2PVP

54%

Campylobacter jejuni

IDP04010
(show subtarget assignments)

1

cloned

No

CPF_2393

110798628

minD

septum site-determining protein MinD [Cl...

265

conserved gene; putative drug target function;

Phase 4: April 2009

3Q9L

43.4%

Clostridium perfringens

Cellular processes

Cell division

IDP04012
(show subtarget assignments)

1

cloned

No

CPF_2355

110800506

virJ

sensor histidine kinase [Clostridium per...

482

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

15.4%

Clostridium perfringens

Cellular processes

Pathogenesis

IDP02382
(show subtarget assignments)

1

cloned

No

lmo0320

16802365

hypothetical protein lmo0320 [Listeria m...

399

Known virulence-Invasion; PMID:16015374

Phase 3: June 2008

Listeria monocytogenes

Cell envelope

Other

IDP04009
(show subtarget assignments)

1

cloned

No

VC2277

15642275

xanthine-guanine phosphoribosyltransfera...

154

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A95

68.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01185
(show subtarget assignments)

1

cloned

No

BA_0280

30253775

glycosyl transferase, group 1 family pro...

443

Drug Target Function

Phase 2: March 2008

2JJM

13.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02385
(show subtarget assignments)

1

cloned

No

Cj0755

15792094

cfrA

putative iron uptake protein [Campylobac...

696

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

2HDF

29.8%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04409
(show subtarget assignments)

1

cloned

No

YPO3965

115349572

putative hybrid two-component system reg...

851

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

9.3%

Yersinia pestis

Regulatory functions

Other

IDP00619
(show subtarget assignments)

1

cloned

No

SACOL2464

57286459

addiction module toxin, Txe/YoeB family ...

88

Virulence Associated Factor

Phase 2: March 2008

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00620
(show subtarget assignments)

1

cloned

No

SACOL0937

57285812

dltC

D-alanine--poly(phosphoribitol) ligase s...

78

Conserved Gene / Pathway

Phase 2: March 2008

1DV5

41%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02389
(show subtarget assignments)

1

cloned

No

lmo0232

16802278

clpC

endopeptidase Clp ATP-binding chain C [L...

820

Known virulence-Invasion; PMID:11083831; Presence of Protease Motifs

Phase 3: June 2008

3PXI

72.8%

Listeria monocytogenes

Energy metabolism

ATP-proton motive force interconversion

IDP02390
(show subtarget assignments)

1

cloned

No

CBU_1718

29542276

groEL

chaperonin, 60 kDa [Coxiella burnetii RS...

552

Conserved; Drug target functions

Phase 3: June 2008

2EU1

75.5%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02391
(show subtarget assignments)

1

cloned

No

FTT0534c

56707667

nrdA

ribonucleotide-diphosphate reductase sub...

590

Drug Target

Phase 3: June 2008

2WGH

31.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP04443
(show subtarget assignments)

1

cloned

No

YPO0506

218927704

clpB

putative Clp ATPase [Yersinia pestis CO9...

867

virulence factor; putative drug target function;

Phase 4: April 2009

1QVR

36.3%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP02394
(show subtarget assignments)

1

cloned

No

YPO1633

16121901

phoQ

sensor protein PhoQ [Yersinia pestis CO9...

484

Conserved; CD; Drug target functions

Phase 3: June 2008

1ID0

20.9%

Yersinia pestis

Regulatory functions

Other

IDP01190
(show subtarget assignments)

1

cloned

No

BA_0872

30254622

N-acetylmuramoyl-L-alanine amidase, fami...

348

Drug Target Function

Phase 2: March 2008

3HMB

25.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00622
(show subtarget assignments)

1

cloned

No

SACOL1878

57284798

epiA

lantibiotic epidermin precursor EpiA

47

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP04017
(show subtarget assignments)

1

cloned

No

CPF_1035

110799411

putative lipoprotein [Clostridium perfri...

309

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP02534
(show subtarget assignments)

1

cloned

No

GBAA4614

47529912

Holliday junction resolvase-like protein...

137

Conserved;

Phase 3: June 2008

1VHX

70.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02399
(show subtarget assignments)

1

cloned

No

GBAA2559

47527848

D-alanyl-D-alanine carboxypeptidase fami...

338

Drug target motif; Drug target functions

Phase 3: June 2008

1XP4

26.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90422
(show subtarget assignments)

8

cloned

No

CT_471

3328905

hypothetical protein [Chlamydia trachoma...

200

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02401
(show subtarget assignments)

1

cloned

No

Cj0574

15791934

ilvI

acetolactate synthase 3 catalytic subuni...

566

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1JSC

40.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04439
(show subtarget assignments)

1

cloned

No

YPO0185

115346005

ssiD

putative taurine dioxygenase [Yersinia p...

282

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GQW

75.9%

Yersinia pestis

Energy metabolism

Other

IDP04440
(show subtarget assignments)

1

cloned

No

YPO0266

115346083

secretion system apparatus protein [Yers...

682

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2X49

15.4%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02315
(show subtarget assignments)

1

cloned

No

GBAA1132

47526402

aceA

isocitrate lyase [Bacillus anthracis str...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4E

71.4%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP02314
(show subtarget assignments)

1

cloned

No

GBAA0599

47525877

neutral protease [Bacillus anthracis str...

566

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1NPC

53%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02440
(show subtarget assignments)

1

cloned

No

lmo0331

16802376

hypothetical protein lmo0331 [Listeria m...

633

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

3BZ5

28.4%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP02407
(show subtarget assignments)

1

cloned

No

GBAA3988

47529279

acpP

acyl carrier protein [Bacillus anthracis...

77

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2X2B

81.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00625
(show subtarget assignments)

1

cloned

No

SACOL2404

57285135

addiction module toxin, Txe/YoeB family ...

88

Virulence Associated Factor

Phase 2: March 2008

2A6Q

51.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP02732
(show subtarget assignments)

1

cloned

No

CBU_1982

29542537

ksgA

dimethyladenosine transferase [Coxiella ...

255

Conserved; Drug target functions

Phase 3: June 2008

3TQS

100%

Coxiella burnetii

Protein synthesis

tRNA and rRNA base modification

IDP02743
(show subtarget assignments)

1

cloned

No

GBAA4383

47529678

bfmbAb

3-methyl-2-oxobutanoate dehydrogenase, b...

327

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

52.9%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP04022
(show subtarget assignments)

1

cloned

No

BAS0095

49183129

preprotein translocase subunit SecE [Bac...

59

Proposed to be essential proteins

Phase 4: April 2009

3DIN

33.9%

Bacillus anthracis

IDP00626
(show subtarget assignments)

1

cloned

No

SACOL2506

57285191

sarT

staphylococcal accessory regulator T

118

Conserved Gene / Pathway

Phase 2: March 2008

2FNP

33.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP02413
(show subtarget assignments)

1

cloned

No

YPO3568

16123712

degS

serine endoprotease [Yersinia pestis CO9...

362

Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...

Phase 3: June 2008

1SOT

63%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01200
(show subtarget assignments)

1

cloned

No

BA_1707

30255995

transglycosylase, SLT family

261

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04451
(show subtarget assignments)

1

cloned

No

YPO1043

218928211

ampM

methionine aminopeptidase [Yersinia pest...

263

drug target; putative drug target function;

Community Interest

1MAT

84%

Yersinia pestis

Protein fate

Protein modification and repair

IDP04030
(show subtarget assignments)

1

cloned

No

YPO2532

115348229

hypothetical protein [Yersinia pestis CO...

70

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP02417
(show subtarget assignments)

1

cloned

No

FTT0812

56707923

gcvH1

glycine cleavage system protein H [Franc...

126

Conserved; Drug target functions

Phase 3: June 2008

1ZKO

40.5%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP04032
(show subtarget assignments)

1

cloned

No

CPF_2081

110798910

stage III sporulation protein AG [Clostr...

201

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04027
(show subtarget assignments)

1

cloned

No

BAS4637

49187628

leucyl-tRNA synthetase [Bacillus anthrac...

802

Proposed to be essential proteins

Phase 4: April 2009

1H3N

45.9%

Bacillus anthracis

IDP90417
(show subtarget assignments)

8

cloned

No

CT_504

3328941

hypothetical protein [Chlamydia trachoma...

288

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02736
(show subtarget assignments)

1

cloned

No

GBAA4352

47778283

argD

acetylornithine aminotransferase [Bacill...

386

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

44%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02422
(show subtarget assignments)

1

cloned

No

YPO1666

16121930

cheA

chemotaxis protein CheA [Yersinia pestis...

723

Conserved; CD; Drug target functions

Phase 3: June 2008

1B3Q

22.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP02423
(show subtarget assignments)

1

cloned

No

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02313
(show subtarget assignments)

1

cloned

No

GBAA3973

47529263

sucD

succinyl-CoA synthetase subunit alpha [B...

300

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JKJ

62.3%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP04448
(show subtarget assignments)

1

cloned

No

YPO0810

218927990

general secretion pathway protein J [Yer...

198

putative drug target function;

Phase 4: April 2009

2RET

20.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02426
(show subtarget assignments)

1

cloned

No

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04036
(show subtarget assignments)

1

cloned

No

CPF_1970

110800938

smc

chromosome segregation protein SMC [Clos...

1185

conserved gene; putative drug target function;

Phase 4: April 2009

3AUX

8.2%

Clostridium perfringens

Cellular processes

Cell division

IDP00281
(show subtarget assignments)

1

cloned

No

AAX48017_776-1130

61652905

N/A

NS1

355

Secreted from infected cells; stimulates protective immune responses (reason for...

Phase 3: June 2008

Dengue virus

host defense modulator

N/A

IDP02812
(show subtarget assignments)

1

cloned

No

FTT1484c

56708523

aceF

dihydrolipoamide acetyltransferase [Fran...

631

Conserved; Drug target functions

Phase 3: June 2008

3DUF

26%

Francisella tularensis

Energy metabolism

Pyruvate dehydrogenase