Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP92566 (show subtarget assignments)	8	selected	No	AAO83387	29725867		polyprotein, partial [Dengue virus 4]	263	potential drug target / Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...	Community Requests	2VBC	67.7%	Dengue virus

IDP02695 (show subtarget assignments)	1	soluble	No	Cj0698	15792047	flgG	flagellar basal body rod protein FlgG [C...	263	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3A69	23.6%	Campylobacter jejuni	Unknown function	Enzymes of unknown specificity

IDP04451 (show subtarget assignments)	1	cloned	No	YPO1043	218928211	ampM	methionine aminopeptidase [Yersinia pest...	263	drug target; putative drug target function;	Community Interest	1MAT	84%	Yersinia pestis	Protein fate	Protein modification and repair

IDP91025 (show subtarget assignments)	8	in_crystallization_trials	No	y3037	22126914	modA	molybdate transporter periplasmic protei...	263	other biological interest / -	Community Requests	3R26	63.9%	Yersinia pestis

IDP02237 (show subtarget assignments)	1	in_pdb 3T4X	No	GBAA3440	47528725		short chain dehydrogenase/reductase fami...	264	Conserved; Essential;	Phase 3: June 2008	3T4X	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02773 (show subtarget assignments)	1	crystallized	No	FTT1389	56708438	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	264	Conserved; Drug target functions	Phase 3: June 2008	1O66	41.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90538 (show subtarget assignments)	8	soluble	No	YPO3412	16123561	speD	S-adenosylmethionine decarboxylase [Yers...	264	Predicted Essential	Community Requests			Yersinia pestis

IDP00924 (show subtarget assignments)	1	purified	No	STM0590	16763967	fepC	iron-enterobactin transporter ATP-bindin...	264	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	28.4%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP04006 (show subtarget assignments)	1	cloned	No	CPF_1351	110800739		putative lipoprotein [Clostridium perfri...	264	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP05139 (show subtarget assignments)	1	soluble	No	BAS0353	49183381	-	amino acid ABC transporter, solute bindi...	264	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQL	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP01640 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4357	47529653		short chain dehydrogenase/reductase fami...	264	Conserved; Essential;	Phase 3: June 2008	3P19	33.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP04702 (show subtarget assignments)	1	cloned	No	YPO0272	218927479		putative type III secretion apparatus pr...	264	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00780 (show subtarget assignments)	1	expressed	No	SACOL0694	57285664		tagH protein, teichoic acid ABC transpor...	264	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	23.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91795 (show subtarget assignments)	8	purified	No	CAA24789	47034		unnamed protein product [Enterococcus fa...	264	other biological interest / Kinase	Community Requests	1J7I	100%	Enterococcus faecalis

IDP05735 (show subtarget assignments)	1	soluble	No	CD1599	126699203	thiD	putative phosphomethylpyrimidine kinase ...	264	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1UB0	44.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP91797 (show subtarget assignments)	8	in_crystallization_trials	No	CAA23892	43749		neomycin phosphotransferase [Escherichia...	264	other biological interest / Kinase	Community Requests	1ND4	100%	Escherichia coli

IDP01090 (show subtarget assignments)	0	work_stopped	No	STM4567	16767808	deoC	deoxyribose-phosphate aldolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1JCL	94.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP05124 (show subtarget assignments)	1	purified	No	BA_3893	30258407		putative cell wall hydrolase [Bacillus a...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05579 (show subtarget assignments)	1	soluble	No	BA_0855	30254440		amino acid ABC transporter, amino acid-b...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2YLN	40.8%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP00987 (show subtarget assignments)	1	soluble	No	STM2147	16765476	thiM	hydroxyethylthiazole kinase	265	Conserved Gene / Pathway	Phase 2: March 2008	1C3Q	36.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00957 (show subtarget assignments)	0	work_stopped	No	STM1202	16764557	ycfH	predicted metallodependent hydrolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1YIX	92.8%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP91393 (show subtarget assignments)	8	cloned	No	VV1_1096	27364519		chromosome segregation ATPase [Vibrio vu...	265	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP05496 (show subtarget assignments)	1	soluble	No	BA_4047	30258554		cell division protein FtsQ [Bacillus ant...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YR1	15.5%	Bacillus anthracis	Cellular processes: Cell division

IDP91341 (show subtarget assignments)	8	cloned	No	VV2_0101	27366558		lipase [Vibrio vulnificus CMCP6]	265	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2ORY	20.4%	Vibrio vulnificus

IDP00044 (show subtarget assignments)	1	in_pdb 3SLB 3SLF 3E4F 3IJW 3N0S 3KZL 3N0M	Yes	BA_2930	30257522	aacC7	aminoglycoside N3-acetyltransferase	265	Virulence	Phase 1: October 2007	3E4F	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00707 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0704	57285674		iron compound ABC transporter, ATP-bindi...	265	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	30.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP05152 (show subtarget assignments)	1	cloned	No	BA_0420	30253954		conserved hypothetical protein [Bacillus...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP01362 (show subtarget assignments)	1	purified	No	VC0158	15640188		glutamate racemase	265	Drug Target Function	Phase 2: March 2008	2JFN	49.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00335 (show subtarget assignments)	1	in_pdb 3OUT	No	FTT1197c	56708260	murI	glutamate racemase	265	Drug Target Function	Phase 2: March 2008	3OUT	100%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04010 (show subtarget assignments)	1	cloned	No	CPF_2393	110798628	minD	septum site-determining protein MinD [Cl...	265	conserved gene; putative drug target function;	Phase 4: April 2009	3Q9L	43.4%	Clostridium perfringens	Cellular processes	Cell division

IDP92076 (show subtarget assignments)	8	selected	No	TGME49_097060	237843677		phosphoglycerate mutase 1, putative [Tox...	265	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1XQ9	70.2%	Toxoplasma gondii

IDP01187 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0485	30254015		prophage LambdaBa04, glycosyl hydrolase,...	265	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	71.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02292 (show subtarget assignments)	1	expressed	No	Cj0078c	15791468	cdtB	cytolethal distending toxin [Campylobact...	265	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008	1SR4	50.9%	Campylobacter jejuni	Cellular processes	Pathogenesis

IDP90578 (show subtarget assignments)	8	expressed	No	YPO3401	16123550	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	266	Predicted Essential	Community Requests	1M3U	75.9%	Yersinia pestis

IDP00566 (show subtarget assignments)	1	purified	No	YPO0279	16120618	hmuV	hemin transport system ATP-binding prote...	266	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	30.5%	Yersinia pestis	Transport and binding proteins	Other

IDP02089 (show subtarget assignments)	1	cloned	No	CBU_0424	29541033	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	266	Conserved; Drug target functions	Phase 3: June 2008	1OY0	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04113 (show subtarget assignments)	1	selected	No	YPO2627	115348319	glmD	putative glucosamine-6-phosphate isomera...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CD5	85.7%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP91531 (show subtarget assignments)	8	soluble	No	VC1887	15641889		hypothetical protein VC1887 [Vibrio chol...	266	potential drug target / Vc1887 was found in a knockout screen for determinants of cell shape by action o...	Community Requests			Vibrio cholerae

IDP01968 (show subtarget assignments)	1	purified	No	STM1954	16765292	fliY	cystine transporter subunit [Salmonella ...	266	Conserved; Drug target functions	Phase 3: June 2008	2YLN	35%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01925 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1846	16122097	fliY	cystine transporter subunit [Yersinia pe...	266	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2YLN	33.8%	Yersinia pestis	Cell envelope	Surface structures

IDP91962 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100007760	298255480		amino acid ABC transporter, amino acid-b...	266	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	4EQ9	40.6%	Streptococcus pneumoniae

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP00778 (show subtarget assignments)	1	cloned	No	SACOL0668	57284264		hydrolase, alpha/beta hydrolase fold fam...	266	Drug Target Function	Phase 2: March 2008	1VA4	26.1%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP00347 (show subtarget assignments)	1	in_pdb 3HFR 3ISV 3IST	Yes	lmo1237	16803277	racE	hypothetical protein lmo1237	266	Drug Target Function	Phase 2: March 2008	3HFR	100%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01344 (show subtarget assignments)	1	crystallized	No	VCA1025	15601778	nagB	glucosamine-6-phosphate deaminase	266	Drug Target Function	Phase 2: March 2008	1CD5	79.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP91062 (show subtarget assignments)	8	cloned	No	YPO0195	16120534	fkpA	peptidyl-prolyl cis-trans isomerase	266	virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...	Community Requests	1Q6U	70.3%	Yersinia pestis

IDP90381 (show subtarget assignments)	8	cloned	No	CT_309	3328725		hypothetical protein [Chlamydia trachoma...	266	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04004 (show subtarget assignments)	1	cloned	No	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP05633 (show subtarget assignments)	1	purified	No	CD2177	126699793		amino-acid ABC transporter,substrate-bin...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IEE	32.6%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP02030 (show subtarget assignments)	1	expressed	No	CBU_1255	29541825		geranyltranstransferase, putative [Coxie...	267	Conserved; Drug target functions	Phase 3: June 2008	3TS7	40.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP05630 (show subtarget assignments)	1	soluble	No	CD1774	126699383		amino acid ABC transporter, substrate-bi...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HV1	36%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP04128 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2899	115348569	suhB	putative inositol monophosphatase family...	267	putative drug target function;	Phase 4: April 2009	2QFL	83.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01920 (show subtarget assignments)	1	expressed	No	CBU_1156	29541728	trpA	tryptophan synthase, alpha subunit [Coxi...	267	Conserved; Drug target functions	Phase 3: June 2008	1V7Y	35.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP05315 (show subtarget assignments)	1	cloned	No	BAS0383	49183411	-	cell wall anchor domain-containing prote...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	23.6%	Bacillus anthracis	Cell envelope: Other

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01464 (show subtarget assignments)	1	soluble	No	VC2520	15642516		ABC transporter, ATP-binding protein	267	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	34.5%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02622 (show subtarget assignments)	1	cloned	No	CBU_0109	29540729		ABC transporter, periplasmic substrate-b...	267	Conserved; Drug target functions	Phase 3: June 2008	3TQW	88.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01257 (show subtarget assignments)	1	expressed	No	BA_5677	30260125		glycosyl transferase, group 2 family pro...	267	Drug Target Function	Phase 2: March 2008	3BCV	11.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91969 (show subtarget assignments)	8	selected	No	SpneCM_010100009453	298255801		peptidyl-prolyl cis-trans isomerase, cyc...	267	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2A2N	31.5%	Streptococcus pneumoniae

IDP02397 (show subtarget assignments)	1	purified	No	FTT1326	56708383	udp	uridine phosphorylase [Francisella tular...	267	Drug Target	Phase 3: June 2008	3O6V	43.1%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP90857 (show subtarget assignments)	8	expressed	No	YPO1614	16121882		hypothetical protein YPO1614 [Yersinia p...	268	Predicted Essential	Community Requests			Yersinia pestis

IDP04160 (show subtarget assignments)	1	in_pdb 3NAV	No	VC1169	9655645		tryptophan synthase, alpha subunit [Vibr...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3NAV	100%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP02158 (show subtarget assignments)	1	cloned	No	Cj1617	15792922	chuD	putative haemin uptake system periplasmi...	268	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3GFV	27%	Campylobacter jejuni	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP05627 (show subtarget assignments)	1	soluble	No	CD1406	126699009		hypothetical protein CD1406 [Clostridium...	268	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05609 (show subtarget assignments)	1	expressed	No	BA_5054	30259543		putative S-layer protein [Bacillus anthr...	268	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	19%	Bacillus anthracis	Cell envelope: Surface structures

IDP01758 (show subtarget assignments)	1	expressed	No	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01210 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2805	30257409		glycosyl hydrolase, family 25, putative ...	268	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	61.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04178 (show subtarget assignments)	1	expressed	No	VC2718	15642712		bioH protein [Vibrio cholerae O1 biovar ...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1M33	49.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90912 (show subtarget assignments)	8	purified	No	YPO1603	16121871		4-amino-4-deoxychorismate lyase [Yersini...	268	Predicted Essential	Community Requests	1ET0	56%	Yersinia pestis

IDP05415 (show subtarget assignments)	1	soluble	No	BA_5219	30259700		putative ABC transporter, substrate-bind...	268	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EF1	49.6%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP91192 (show subtarget assignments)	1	in_crystallization_trials	No	BAD95814	62857277	neoU	aminoglycoside 3'-phosphotransferase [St...	268	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R78	38.1%	Streptomyces fradiae

IDP91967 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100008960	298255704		amino acid ABC transporter, periplasmic ...	268	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1XT8	28.7%	Streptococcus pneumoniae

IDP91871 (show subtarget assignments)	8	selected	No	AAB05624	1209528	vanYB	D,D-carboxypeptidase [Enterococcus faeca...	268	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests			Enterococcus faecalis

IDP04283 (show subtarget assignments)	1	expressed	No	YPO1971	218929083	hutG	putative N-formylglutamate amidohydrolas...	268	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Energy metabolism	Amino acids and amines

IDP05326 (show subtarget assignments)	1	cloned	No	CD3562	126701188	murI	glutamate racemase [Clostridium difficil...	268	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3OUT	45.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02306 (show subtarget assignments)	1	cloned	No	Cj0079c	15791469	cdtA	cytolethal distending toxin [Campylobact...	268	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008	1SR4	24.3%	Campylobacter jejuni	Cellular processes	Pathogenesis

IDP90532 (show subtarget assignments)	8	soluble	No	VC2391	15642388		dihydrodipicolinate reductase [Vibrio ch...	269	Predicted Essential	Community Requests	1ARZ	63.9%	Vibrio cholerae

IDP90166 (show subtarget assignments)	8	soluble	No	CD1837	126699446	aroE	shikimate dehydrogenase [Clostridium dif...	269	Potential drug target. Shikimate pathway enzyme	Community Requests	3FBT	42%	Clostridium difficile

IDP02029 (show subtarget assignments)	1	in_crystallization_trials	No	STM2844	16766150		hypothetical protein STM2844 [Salmonella...	269	Essential; Drug target functions	Phase 3: June 2008			Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP05245 (show subtarget assignments)	1	soluble	No	lmo2349	16804387	-	hypothetical protein lmo2349 [Listeria m...	269	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2O1M	71%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP01866 (show subtarget assignments)	1	crystallized	No	FTT1772c	56708766	trpA	tryptophan synthase subunit alpha [Franc...	269	Drug Target	Phase 3: June 2008	3NAV	61%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00752 (show subtarget assignments)	1	purified	No	SACOL2211	57284992		ABC transporter, ATP-binding protein	269	Drug Target Function	Phase 2: March 2008	3GFO	37.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01405 (show subtarget assignments)	1	purified	No	VC0905	161582017	metQ	lipoprotein YaeC	269	Conserved Gene / Pathway	Phase 2: March 2008	3K2D	72.9%	Vibrio cholerae	Cell envelope	Other

IDP00018 (show subtarget assignments)	0	work_stopped	No	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91933 (show subtarget assignments)	8	selected	No	SpneCM_010100001964	298254365		VicX protein [Streptococcus pneumoniae s...	269	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP02749 (show subtarget assignments)	1	soluble	No	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP90908 (show subtarget assignments)	8	crystallized	No	STM1198	16764553	pabC	4-amino-4-deoxychorismate lyase [Salmone...	269	Predicted Essential	Community Requests	1ET0	69.9%	Salmonella enterica

IDP00588 (show subtarget assignments)	1	purified	No	YPO2077	16122316	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	87.8%	Yersinia pestis	Cellular processes	Cell division

IDP02196 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0734	47526018	thiD-1	phosphomethylpyrimidine kinase [Bacillus...	270	Conserved; Drug target functions	Phase 3: June 2008	2I5B	48.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP05733 (show subtarget assignments)	1	cloned	No	CD1208	126698804		putative RNA methyltransferase [Clostrid...	270	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3HP7	50.7%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP00975 (show subtarget assignments)	1	cloned	No	STM1815	16765156	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	93.3%	Salmonella enterica	Cellular processes	Cell division

IDP05714 (show subtarget assignments)	1	purified	No	BA_0175	30253683		putative ABC transporter, substrate-bind...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3K2D	37.8%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05634 (show subtarget assignments)	1	soluble	No	CD2174	126699790		amino-acid ABC transporter,substrate-bin...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IEE	29.3%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05064 (show subtarget assignments)	1	cloned	No	CD2370	126699985	nadC	nicotinate-nucleotide pyrophosphorylase ...	270	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1X1O	46.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05370 (show subtarget assignments)	1	cloned	No	BA_5220	30259701		putative ABC transporter, substrate-bind...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EF1	50.7%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05504 (show subtarget assignments)	1	purified	No	CD0869	126698446	modA	putative molybdenum ABC transporter,subs...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1AMF	31.9%	Clostridium difficile	Transport and binding proteins: Anions

IDP02680 (show subtarget assignments)	1	soluble	No	Cj0697	15792046	flgG2	flagellar basal-body rod protein [Campyl...	270	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP01216 (show subtarget assignments)	1	expressed	No	BA_3577	30258105		glycosyl transferase, group 1 family pro...	270	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP92566
(show subtarget assignments)

8

selected

No

AAO83387

29725867

polyprotein, partial [Dengue virus 4]

263

potential drug target / Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...

Community Requests

2VBC

67.7%

Dengue virus

IDP02695
(show subtarget assignments)

1

soluble

No

Cj0698

15792047

flgG

flagellar basal body rod protein FlgG [C...

263

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3A69

23.6%

Campylobacter jejuni

Unknown function

Enzymes of unknown specificity

IDP04451
(show subtarget assignments)

1

cloned

No

YPO1043

218928211

ampM

methionine aminopeptidase [Yersinia pest...

263

drug target; putative drug target function;

Community Interest

1MAT

84%

Yersinia pestis

Protein fate

Protein modification and repair

IDP91025
(show subtarget assignments)

8

in_crystallization_trials

No

y3037

22126914

modA

molybdate transporter periplasmic protei...

263

other biological interest / -

Community Requests

3R26

63.9%

Yersinia pestis

IDP02237
(show subtarget assignments)

1

in_pdb
3T4X

No

GBAA3440

47528725

short chain dehydrogenase/reductase fami...

264

Conserved; Essential;

Phase 3: June 2008

3T4X

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02773
(show subtarget assignments)

1

crystallized

No

FTT1389

56708438

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

264

Conserved; Drug target functions

Phase 3: June 2008

1O66

41.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90538
(show subtarget assignments)

8

soluble

No

YPO3412

16123561

speD

S-adenosylmethionine decarboxylase [Yers...

264

Predicted Essential

Community Requests

Yersinia pestis

IDP00924
(show subtarget assignments)

1

purified

No

STM0590

16763967

fepC

iron-enterobactin transporter ATP-bindin...

264

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

28.4%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP04006
(show subtarget assignments)

1

cloned

No

CPF_1351

110800739

putative lipoprotein [Clostridium perfri...

264

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP05139
(show subtarget assignments)

1

soluble

No

BAS0353

49183381

-

amino acid ABC transporter, solute bindi...

264

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQL

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP01640
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4357

47529653

short chain dehydrogenase/reductase fami...

264

Conserved; Essential;

Phase 3: June 2008

3P19

33.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP04702
(show subtarget assignments)

1

cloned

No

YPO0272

218927479

putative type III secretion apparatus pr...

264

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00780
(show subtarget assignments)

1

expressed

No

SACOL0694

57285664

tagH protein, teichoic acid ABC transpor...

264

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

23.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91795
(show subtarget assignments)

8

purified

No

CAA24789

47034

unnamed protein product [Enterococcus fa...

264

other biological interest / Kinase

Community Requests

1J7I

100%

Enterococcus faecalis

IDP05735
(show subtarget assignments)

1

soluble

No

CD1599

126699203

thiD

putative phosphomethylpyrimidine kinase ...

264

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1UB0

44.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP91797
(show subtarget assignments)

8

in_crystallization_trials

No

CAA23892

43749

neomycin phosphotransferase [Escherichia...

264

other biological interest / Kinase

Community Requests

1ND4

100%

Escherichia coli

IDP01090
(show subtarget assignments)

0

work_stopped

No

STM4567

16767808

deoC

deoxyribose-phosphate aldolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1JCL

94.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP05124
(show subtarget assignments)

1

purified

No

BA_3893

30258407

putative cell wall hydrolase [Bacillus a...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05579
(show subtarget assignments)

1

soluble

No

BA_0855

30254440

amino acid ABC transporter, amino acid-b...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2YLN

40.8%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP00987
(show subtarget assignments)

1

soluble

No

STM2147

16765476

thiM

hydroxyethylthiazole kinase

265

Conserved Gene / Pathway

Phase 2: March 2008

1C3Q

36.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00957
(show subtarget assignments)

0

work_stopped

No

STM1202

16764557

ycfH

predicted metallodependent hydrolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1YIX

92.8%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP91393
(show subtarget assignments)

8

cloned

No

VV1_1096

27364519

chromosome segregation ATPase [Vibrio vu...

265

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP05496
(show subtarget assignments)

1

soluble

No

BA_4047

30258554

cell division protein FtsQ [Bacillus ant...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YR1

15.5%

Bacillus anthracis

Cellular processes: Cell division

IDP91341
(show subtarget assignments)

8

cloned

No

VV2_0101

27366558

lipase [Vibrio vulnificus CMCP6]

265

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2ORY

20.4%

Vibrio vulnificus

IDP00044
(show subtarget assignments)

1

in_pdb
3SLB
3SLF
3E4F
3IJW
3N0S
3KZL
3N0M

Yes

BA_2930

30257522

aacC7

aminoglycoside N3-acetyltransferase

265

Virulence

Phase 1: October 2007

3E4F

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00707
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0704

57285674

iron compound ABC transporter, ATP-bindi...

265

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

30.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP05152
(show subtarget assignments)

1

cloned

No

BA_0420

30253954

conserved hypothetical protein [Bacillus...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP01362
(show subtarget assignments)

1

purified

No

VC0158

15640188

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

2JFN

49.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00335
(show subtarget assignments)

1

in_pdb
3OUT

No

FTT1197c

56708260

murI

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

3OUT

100%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04010
(show subtarget assignments)

1

cloned

No

CPF_2393

110798628

minD

septum site-determining protein MinD [Cl...

265

conserved gene; putative drug target function;

Phase 4: April 2009

3Q9L

43.4%

Clostridium perfringens

Cellular processes

Cell division

IDP92076
(show subtarget assignments)

8

selected

No

TGME49_097060

237843677

phosphoglycerate mutase 1, putative [Tox...

265

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1XQ9

70.2%

Toxoplasma gondii

IDP01187
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0485

30254015

prophage LambdaBa04, glycosyl hydrolase,...

265

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

71.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02292
(show subtarget assignments)

1

expressed

No

Cj0078c

15791468

cdtB

cytolethal distending toxin [Campylobact...

265

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

1SR4

50.9%

Campylobacter jejuni

Cellular processes

Pathogenesis

IDP90578
(show subtarget assignments)

8

expressed

No

YPO3401

16123550

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

266

Predicted Essential

Community Requests

1M3U

75.9%

Yersinia pestis

IDP00566
(show subtarget assignments)

1

purified

No

YPO0279

16120618

hmuV

hemin transport system ATP-binding prote...

266

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

30.5%

Yersinia pestis

Transport and binding proteins

Other

IDP02089
(show subtarget assignments)

1

cloned

No

CBU_0424

29541033

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

266

Conserved; Drug target functions

Phase 3: June 2008

1OY0

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04113
(show subtarget assignments)

1

selected

No

YPO2627

115348319

glmD

putative glucosamine-6-phosphate isomera...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CD5

85.7%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP91531
(show subtarget assignments)

8

soluble

No

VC1887

15641889

hypothetical protein VC1887 [Vibrio chol...

266

potential drug target / Vc1887 was found in a knockout screen for determinants of cell shape by action o...

Community Requests

Vibrio cholerae

IDP01968
(show subtarget assignments)

1

purified

No

STM1954

16765292

fliY

cystine transporter subunit [Salmonella ...

266

Conserved; Drug target functions

Phase 3: June 2008

2YLN

35%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01925
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1846

16122097

fliY

cystine transporter subunit [Yersinia pe...

266

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2YLN

33.8%

Yersinia pestis

Cell envelope

Surface structures

IDP91962
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100007760

298255480

amino acid ABC transporter, amino acid-b...

266

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

4EQ9

40.6%

Streptococcus pneumoniae

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP00778
(show subtarget assignments)

1

cloned

No

SACOL0668

57284264

hydrolase, alpha/beta hydrolase fold fam...

266

Drug Target Function

Phase 2: March 2008

1VA4

26.1%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP00347
(show subtarget assignments)

1

in_pdb
3HFR
3ISV
3IST

Yes

lmo1237

16803277

racE

hypothetical protein lmo1237

266

Drug Target Function

Phase 2: March 2008

3HFR

100%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01344
(show subtarget assignments)

1

crystallized

No

VCA1025

15601778

nagB

glucosamine-6-phosphate deaminase

266

Drug Target Function

Phase 2: March 2008

1CD5

79.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP91062
(show subtarget assignments)

8

cloned

No

YPO0195

16120534

fkpA

peptidyl-prolyl cis-trans isomerase

266

virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...

Community Requests

1Q6U

70.3%

Yersinia pestis

IDP90381
(show subtarget assignments)

8

cloned

No

CT_309

3328725

hypothetical protein [Chlamydia trachoma...

266

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04004
(show subtarget assignments)

1

cloned

No

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP05633
(show subtarget assignments)

1

purified

No

CD2177

126699793

amino-acid ABC transporter,substrate-bin...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IEE

32.6%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP02030
(show subtarget assignments)

1

expressed

No

CBU_1255

29541825

geranyltranstransferase, putative [Coxie...

267

Conserved; Drug target functions

Phase 3: June 2008

3TS7

40.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP05630
(show subtarget assignments)

1

soluble

No

CD1774

126699383

amino acid ABC transporter, substrate-bi...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HV1

36%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP04128
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2899

115348569

suhB

putative inositol monophosphatase family...

267

putative drug target function;

Phase 4: April 2009

2QFL

83.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01920
(show subtarget assignments)

1

expressed

No

CBU_1156

29541728

trpA

tryptophan synthase, alpha subunit [Coxi...

267

Conserved; Drug target functions

Phase 3: June 2008

1V7Y

35.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP05315
(show subtarget assignments)

1

cloned

No

BAS0383

49183411

-

cell wall anchor domain-containing prote...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

23.6%

Bacillus anthracis

Cell envelope: Other

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01464
(show subtarget assignments)

1

soluble

No

VC2520

15642516

ABC transporter, ATP-binding protein

267

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

34.5%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02622
(show subtarget assignments)

1

cloned

No

CBU_0109

29540729

ABC transporter, periplasmic substrate-b...

267

Conserved; Drug target functions

Phase 3: June 2008

3TQW

88.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01257
(show subtarget assignments)

1

expressed

No

BA_5677

30260125

glycosyl transferase, group 2 family pro...

267

Drug Target Function

Phase 2: March 2008

3BCV

11.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91969
(show subtarget assignments)

8

selected

No

SpneCM_010100009453

298255801

peptidyl-prolyl cis-trans isomerase, cyc...

267

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2A2N

31.5%

Streptococcus pneumoniae

IDP02397
(show subtarget assignments)

1

purified

No

FTT1326

56708383

udp

uridine phosphorylase [Francisella tular...

267

Drug Target

Phase 3: June 2008

3O6V

43.1%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP90857
(show subtarget assignments)

8

expressed

No

YPO1614

16121882

hypothetical protein YPO1614 [Yersinia p...

268

Predicted Essential

Community Requests

Yersinia pestis

IDP04160
(show subtarget assignments)

1

in_pdb
3NAV

No

VC1169

9655645

tryptophan synthase, alpha subunit [Vibr...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3NAV

100%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP02158
(show subtarget assignments)

1

cloned

No

Cj1617

15792922

chuD

putative haemin uptake system periplasmi...

268

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3GFV

27%

Campylobacter jejuni

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP05627
(show subtarget assignments)

1

soluble

No

CD1406

126699009

hypothetical protein CD1406 [Clostridium...

268

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05609
(show subtarget assignments)

1

expressed

No

BA_5054

30259543

putative S-layer protein [Bacillus anthr...

268

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

19%

Bacillus anthracis

Cell envelope: Surface structures

IDP01758
(show subtarget assignments)

1

expressed

No

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01210
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2805

30257409

glycosyl hydrolase, family 25, putative ...

268

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

61.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04178
(show subtarget assignments)

1

expressed

No

VC2718

15642712

bioH protein [Vibrio cholerae O1 biovar ...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1M33

49.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90912
(show subtarget assignments)

8

purified

No

YPO1603

16121871

4-amino-4-deoxychorismate lyase [Yersini...

268

Predicted Essential

Community Requests

1ET0

56%

Yersinia pestis

IDP05415
(show subtarget assignments)

1

soluble

No

BA_5219

30259700

putative ABC transporter, substrate-bind...

268

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EF1

49.6%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP91192
(show subtarget assignments)

1

in_crystallization_trials

No

BAD95814

62857277

neoU

aminoglycoside 3'-phosphotransferase [St...

268

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R78

38.1%

Streptomyces fradiae

IDP91967
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100008960

298255704

amino acid ABC transporter, periplasmic ...

268

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1XT8

28.7%

Streptococcus pneumoniae

IDP91871
(show subtarget assignments)

8

selected

No

AAB05624

1209528

vanYB

D,D-carboxypeptidase [Enterococcus faeca...

268

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

Enterococcus faecalis

IDP04283
(show subtarget assignments)

1

expressed

No

YPO1971

218929083

hutG

putative N-formylglutamate amidohydrolas...

268

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP05326
(show subtarget assignments)

1

cloned

No

CD3562

126701188

murI

glutamate racemase [Clostridium difficil...

268

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3OUT

45.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02306
(show subtarget assignments)

1

cloned

No

Cj0079c

15791469

cdtA

cytolethal distending toxin [Campylobact...

268

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

1SR4

24.3%

Campylobacter jejuni

Cellular processes

Pathogenesis

IDP90532
(show subtarget assignments)

8

soluble

No

VC2391

15642388

dihydrodipicolinate reductase [Vibrio ch...

269

Predicted Essential

Community Requests

1ARZ

63.9%

Vibrio cholerae

IDP90166
(show subtarget assignments)

8

soluble

No

CD1837

126699446

aroE

shikimate dehydrogenase [Clostridium dif...

269

Potential drug target. Shikimate pathway enzyme

Community Requests

3FBT

42%

Clostridium difficile

IDP02029
(show subtarget assignments)

1

in_crystallization_trials

No

STM2844

16766150

hypothetical protein STM2844 [Salmonella...

269

Essential; Drug target functions

Phase 3: June 2008

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP05245
(show subtarget assignments)

1

soluble

No

lmo2349

16804387

-

hypothetical protein lmo2349 [Listeria m...

269

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2O1M

71%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP01866
(show subtarget assignments)

1

crystallized

No

FTT1772c

56708766

trpA

tryptophan synthase subunit alpha [Franc...

269

Drug Target

Phase 3: June 2008

3NAV

61%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00752
(show subtarget assignments)

1

purified

No

SACOL2211

57284992

ABC transporter, ATP-binding protein

269

Drug Target Function

Phase 2: March 2008

3GFO

37.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01405
(show subtarget assignments)

1

purified

No

VC0905

161582017

metQ

lipoprotein YaeC

269

Conserved Gene / Pathway

Phase 2: March 2008

3K2D

72.9%

Vibrio cholerae

Cell envelope

Other

IDP00018
(show subtarget assignments)

0

work_stopped

No

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91933
(show subtarget assignments)

8

selected

No

SpneCM_010100001964

298254365

VicX protein [Streptococcus pneumoniae s...

269

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP02749
(show subtarget assignments)

1

soluble

No

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP90908
(show subtarget assignments)

8

crystallized

No

STM1198

16764553

pabC

4-amino-4-deoxychorismate lyase [Salmone...

269

Predicted Essential

Community Requests

1ET0

69.9%

Salmonella enterica

IDP00588
(show subtarget assignments)

1

purified

No

YPO2077

16122316

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

87.8%

Yersinia pestis

Cellular processes

Cell division

IDP02196
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0734

47526018

thiD-1

phosphomethylpyrimidine kinase [Bacillus...

270

Conserved; Drug target functions

Phase 3: June 2008

2I5B

48.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP05733
(show subtarget assignments)

1

cloned

No

CD1208

126698804

putative RNA methyltransferase [Clostrid...

270

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3HP7

50.7%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP00975
(show subtarget assignments)

1

cloned

No

STM1815

16765156

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

93.3%

Salmonella enterica

Cellular processes

Cell division

IDP05714
(show subtarget assignments)

1

purified

No

BA_0175

30253683

putative ABC transporter, substrate-bind...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3K2D

37.8%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05634
(show subtarget assignments)

1

soluble

No

CD2174

126699790

amino-acid ABC transporter,substrate-bin...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IEE

29.3%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05064
(show subtarget assignments)

1

cloned

No

CD2370

126699985

nadC

nicotinate-nucleotide pyrophosphorylase ...

270

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1X1O

46.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05370
(show subtarget assignments)

1

cloned

No

BA_5220

30259701

putative ABC transporter, substrate-bind...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EF1

50.7%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05504
(show subtarget assignments)

1

purified

No

CD0869

126698446

modA

putative molybdenum ABC transporter,subs...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1AMF

31.9%

Clostridium difficile

Transport and binding proteins: Anions

IDP02680
(show subtarget assignments)

1

soluble

No

Cj0697

15792046

flgG2

flagellar basal-body rod protein [Campyl...

270

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP01216
(show subtarget assignments)

1

expressed

No

BA_3577

30258105

glycosyl transferase, group 1 family pro...

270

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides