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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 22 of 60, showing 100 records out of 5973 total, starting on record 2101
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04338
(
show subtarget assignments
)
1
cloned
No
CPF_1446
110801179
sodF
Mn/Fe superoxide dismutase [Clostridium ...
227
conserved gene; putative drug target function;
Phase 4: April 2009
1JR9
44.9%
Clostridium perfringens
Cellular processes
Detoxification
IDP00785
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL0904
57285780
pathogenicity island protein
175
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP01613
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1927
16765269
yecG
universal stress protein UspC [Salmonell...
142
Conserved; Drug target functions
Phase 3: June 2008
1JMV
35.2%
Salmonella enterica
Cellular processes
Adaptations to atypical conditions
IDP00784
(
show subtarget assignments
)
1
purified
No
SACOL0896
57284355
pathogenicity island protein
289
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP00782
(
show subtarget assignments
)
1
cloned
No
SACOL0857
57284318
staphylocoagulase precursor, putative
508
Conserved Gene / Pathway
Phase 2: March 2008
2A1D
16.9%
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP00783
(
show subtarget assignments
)
0
work_stopped
No
SACOL0885
57284344
pathogenicity island protein, integrase ...
406
Conserved Gene / Pathway
Phase 2: March 2008
3NKH
54.2%
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP00781
(
show subtarget assignments
)
1
expressed
No
SACOL0845
57284307
est
carboxylesterase
246
Conserved Gene / Pathway
Phase 2: March 2008
1R1D
57.7%
Staphylococcus aureus
Cellular processes
Detoxification
IDP01603
(
show subtarget assignments
)
1
cloned
No
STM1971
16765309
fliH
flagellar assembly protein H [Salmonella...
235
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00043
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_2629
30257246
acetyltransferase, CYSE/LACA/LPXA/NODL f...
210
Virulence
Phase 1: October 2007
4E8L
63.3%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04337
(
show subtarget assignments
)
1
cloned
No
CPF_0720
110801161
splB
spore photoproduct lyase [Clostridium pe...
340
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP00420
(
show subtarget assignments
)
1
purified
No
YPO1207
16121498
katA
catalase
480
Virulence Associated Factor
Phase 2: March 2008
1M85
84.2%
Yersinia pestis
Cellular processes
Detoxification
IDP01516
(
show subtarget assignments
)
1
crystallized
No
VC0576
15640598
sspA
stringent starvation protein A
211
Conserved Gene / Pathway
Phase 2: March 2008
1YY7
73.9%
Vibrio cholerae
Cellular processes
Adaptations to atypical conditions
IDP00770
(
show subtarget assignments
)
8
in_pdb
3R2I
No
SACOL0473
57285500
superantigen-like protein
232
Virulence Associated Factor
Community Requests
3R2I
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP00769
(
show subtarget assignments
)
0
work_stopped
No
SACOL0472
57285499
superantigen-like protein
308
Virulence Associated Factor
Phase 2: March 2008
3URY
60.7%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP01510
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC0731
15640750
antioxidant, AhpC/Tsa family
207
Conserved Gene / Pathway
Phase 2: March 2008
1ZOF
55.1%
Vibrio cholerae
Cellular processes
Detoxification
IDP00085
(
show subtarget assignments
)
1
in_crystallization_trials
No
NTL01ST1174
16419726
nagZ
putative glycosyl hydrolase
341
Virulence
Phase 1: October 2007
1TR9
55.4%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP00768
(
show subtarget assignments
)
0
work_stopped
No
SACOL0470
57285497
superantigen-like protein
352
Virulence Associated Factor
Phase 2: March 2008
3URY
40.9%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP01507
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC2045
15642047
superoxide dismutase, Fe
194
Conserved Gene / Pathway
Phase 2: March 2008
2W7W
86.6%
Vibrio cholerae
Cellular processes
Detoxification
IDP00763
(
show subtarget assignments
)
1
expressed
No
SACOL0262
57286722
Ccholoylglycine hydrolase family protein...
330
Conserved Gene / Pathway
Phase 2: March 2008
2OQC
32.4%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP02788
(
show subtarget assignments
)
1
expressed
No
CBU_0140
29540760
ftsA
cell division protein FtsA [Coxiella bur...
410
Conserved; Drug target functions
Phase 3: June 2008
1E4F
22.9%
Coxiella burnetii
Cellular processes
Cell division
IDP00762
(
show subtarget assignments
)
1
purified
No
SACOL0209
57286673
staphylocoagulase precursor
636
Conserved Gene / Pathway
Phase 2: March 2008
2A1D
29.4%
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP00042
(
show subtarget assignments
)
1
soluble
No
BA_2507
30257134
bla1
beta-lactamase
309
Virulence
Phase 1: October 2007
3QHY
87.7%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00170
(
show subtarget assignments
)
1
soluble
No
VCA0865
15601620
hap
hemagglutinin/protease
609
Virulence
Phase 1: October 2007
1EZM
31.4%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP02789
(
show subtarget assignments
)
1
cloned
No
CBU_0141
29540761
ftsZ
cell division protein FtsZ [Coxiella bur...
386
Conserved; Drug target functions
Phase 3: June 2008
2VAW
63.4%
Coxiella burnetii
Cellular processes
Cell division
IDP00414
(
show subtarget assignments
)
1
expressed
No
YPO1322
16121604
deoR
DNA-binding transcriptional repressor
254
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00415
(
show subtarget assignments
)
1
expressed
No
YPO3767
16123903
fadA
3-ketoacyl-CoA thiolase
387
Virulence Associated Factor
Phase 2: March 2008
3GOA
79.8%
Yersinia pestis
Cellular processes
Detoxification
IDP00754
(
show subtarget assignments
)
0
work_stopped
No
SACOL0095
57286644
spa
immunoglobulin G binding protein A precu...
508
Conserved Gene / Pathway
Phase 2: March 2008
1BDC
11.6%
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP00169
(
show subtarget assignments
)
1
expressed
No
VCA0218
15600987
No Data
thermolabile hemolysin
418
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00410
(
show subtarget assignments
)
1
cloned
No
YPO0548
16120876
ftsL
cell division protein FtsL
105
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP02453
(
show subtarget assignments
)
1
in_pdb
3IGJ
3HJJ
No
GBAA3402
47528687
maA
maltose O-acetyltransferase [Bacillus an...
187
Drug target motif; Conserved; Essential; Drug target functions
Phase 3: June 2008
3HJJ
100%
Bacillus anthracis
Cellular processes
Detoxification
IDP00168
(
show subtarget assignments
)
1
cloned
No
VC2209
15642774
vibF
nonribosomal peptide synthetase VibF, au...
2413
Virulence
Phase 1: October 2007
2VSQ
10.2%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP01478
(
show subtarget assignments
)
1
purified
No
VC2772
15642765
ParB family protein
293
Conserved Gene / Pathway
Phase 2: March 2008
1VZ0
33.8%
Vibrio cholerae
Cellular processes
Cell division
IDP01476
(
show subtarget assignments
)
1
soluble
No
VC2694
15642689
superoxide dismutase, Mn
222
Conserved Gene / Pathway
Phase 2: March 2008
2RCV
48.2%
Vibrio cholerae
Cellular processes
Detoxification
IDP00409
(
show subtarget assignments
)
1
purified
No
YPO1601
16121869
fabF
3-oxoacyl-(acyl carrier protein) synthas...
413
Conserved Gene / Pathway
Phase 2: March 2008
1B3N
89.1%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00040
(
show subtarget assignments
)
1
purified
No
BA_2042
46395770
Metallothiol transferase fosB 1 (Fosfomy...
138
Virulence
Phase 1: October 2007
3UH9
67.4%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00167
(
show subtarget assignments
)
8
in_pdb
3FZY
Yes
VC1451
4455065
rtxA
RTX toxin RtxA
4545
Virulence
Community Requests
3EEB
4.6%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00166
(
show subtarget assignments
)
1
expressed
No
VC1450
15641461
rtxC
RTX toxin activating protein
153
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00631
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1537
57284636
scpB
segregation and condensation protein B
180
Conserved Gene / Pathway
Phase 2: March 2008
1T6S
23.9%
Staphylococcus aureus
Cellular processes
Cell division
IDP00165
(
show subtarget assignments
)
1
cloned
No
VC0844
15640861
acfA
accessory colonization factor AcfA
215
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00164
(
show subtarget assignments
)
1
soluble
No
VC0841
15640858
acfC
accessory colonization factor AcfC
256
Virulence
Phase 1: October 2007
3FIR
50%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00404
(
show subtarget assignments
)
1
soluble
No
YPCD1.48
16082736
virG
needle complex outer membrane lipoprotei...
131
Virulence Associated Factor
Phase 2: March 2008
2YJL
23.7%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP00733
(
show subtarget assignments
)
1
selected
No
SACOL2419
57285149
hlgA
gamma-hemolysin, component A
309
Conserved Gene / Pathway
Phase 2: March 2008
2QK7
90.9%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP01443
(
show subtarget assignments
)
1
soluble
No
VC2061
15642061
ParA family protein
258
Conserved Gene / Pathway
Phase 2: March 2008
1WCV
34.1%
Vibrio cholerae
Cellular processes
Cell division
IDP00163
(
show subtarget assignments
)
0
work_stopped
No
VC0838
15640855
tcpN/toxT
TCP pilus virulence regulatory protein
276
Virulence
Phase 1: October 2007
3GBG
100%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00162
(
show subtarget assignments
)
1
soluble
No
VC0837
15640854
tcpF
toxin co-regulated pilus biosynthesis pr...
338
Virulence
Phase 1: October 2007
3OC5
93.5%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00041
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_2409
30257040
chloramphenicol acetyltransferase
216
Virulence
Phase 1: October 2007
1QCA
41.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00724
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1822
57286255
arsR
arsenical resistance operon repressor
104
Conserved Gene / Pathway
Phase 2: March 2008
1R1T
31.7%
Staphylococcus aureus
Cellular processes
Detoxification
IDP00161
(
show subtarget assignments
)
1
soluble
No
VC0835
15640852
tcpT
toxin co-regulated pilus biosynthesis pr...
503
Virulence
Phase 1: October 2007
1P9R
23.5%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00039
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_1960
30256617
aminoglycoside 6-adenylyltransferase, pu...
290
Virulence
Phase 1: October 2007
2PBE
37.9%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00160
(
show subtarget assignments
)
1
soluble
No
VC0834
15640851
tcpS
toxin co-regulated pilus biosynthesis pr...
152
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00714
(
show subtarget assignments
)
1
cloned
No
SACOL1198
57285941
ftsA
cell division protein FtsA
470
Drug Target Function
Phase 2: March 2008
1E4F
18.3%
Staphylococcus aureus
Cellular processes
Cell division
IDP02719
(
show subtarget assignments
)
1
cloned
No
lmo0262
16802308
inlG
internalin G [Listeria monocytogenes EGD...
490
Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815
Phase 3: June 2008
1M9S
31.6%
Listeria monocytogenes
Cellular processes
Pathogenesis
IDP00159
(
show subtarget assignments
)
1
purified
No
VC0831
15640848
tcpC
toxin co-regulated pilus biosynthesis ou...
489
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01402
(
show subtarget assignments
)
1
cloned
No
VC0843
15640860
tagE protein
302
Drug Target Function
Phase 2: March 2008
3SLU
18.9%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP02714
(
show subtarget assignments
)
1
purified
No
FTT1231
56708293
mesJ
PP-loop family protein [Francisella tula...
398
Conserved; Drug target functions
Phase 3: June 2008
1NI5
27.3%
Francisella tularensis
Cellular processes
Cell division
IDP00158
(
show subtarget assignments
)
1
soluble
No
VC0830
15640847
tcpQ
toxin co-regulated pilus biosynthesis pr...
150
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP02708
(
show subtarget assignments
)
1
cloned
No
lmo0291
16802337
hypothetical protein lmo0291 [Listeria m...
276
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2DKF
13.4%
Listeria monocytogenes
Cellular processes
Toxin production and resistance
IDP00157
(
show subtarget assignments
)
1
soluble
No
VC0829
15640846
tcpB
toxin co-regulated pilus biosynthesis pr...
430
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP02706
(
show subtarget assignments
)
1
cloned
No
FTT0470
56707612
apaH
diadenosine tetraphosphatase [Francisell...
275
Drug Target
Phase 3: June 2008
2DFJ
37.8%
Francisella tularensis
Cellular processes
Adaptations to atypical conditions
IDP04324
(
show subtarget assignments
)
1
purified
No
CPF_2814
110799621
regulatory protein SpoVG [Clostridium pe...
90
conserved gene; putative drug target function;
Phase 4: April 2009
2IA9
55.6%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP00156
(
show subtarget assignments
)
1
purified
No
VC0407
15640434
mshF
MSHA biogenesis protein MshF
150
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00076
(
show subtarget assignments
)
1
in_pdb
3NX4
No
NT01ST4228
16421936
yhdH
putative oxidoreductase
324
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3NX4
100%
Salmonella enterica
Cellular processes
Cell division
IDP00699
(
show subtarget assignments
)
1
in_pdb
3ED6
3FG0
Yes
SACOL2628
57286533
betB
betaine aldehyde dehydrogenase
496
Conserved Gene / Pathway
Phase 2: March 2008
3ED6
100%
Staphylococcus aureus
Cellular processes
Adaptations to atypical conditions
IDP00698
(
show subtarget assignments
)
1
in_pdb
3V4E
3FTT
Yes
SACOL2570
57286478
galactoside O-acetyltransferase
199
Drug Target Function
Phase 2: March 2008
3FTT
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP01378
(
show subtarget assignments
)
1
cloned
No
VC0410
15640437
MSHA pilin protein MshC
162
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01377
(
show subtarget assignments
)
1
cloned
No
VC0409
15640436
MSHA pilin protein MshA
178
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01376
(
show subtarget assignments
)
1
soluble
No
VC0400
15640427
MSHA biogenesis protein MshJ
216
Drug Target Function
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00155
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC0405
15640432
mshE
MSHA biogenesis protein MshE
575
Virulence
Phase 1: October 2007
1P9R
31.7%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00038
(
show subtarget assignments
)
1
in_pdb
3SR3
3GJZ
3T5M
3TYX
3U1B
No
BA_1949
30256607
microcin immunity protein MccF
333
Virulence
Phase 1: October 2007
3GJZ
100%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00343
(
show subtarget assignments
)
1
expressed
No
lmo2235
16804274
hypothetical protein lmo2235
641
Drug Target Function
Phase 2: March 2008
3K30
29.4%
Listeria monocytogenes
Cellular processes
Detoxification
IDP01360
(
show subtarget assignments
)
1
purified
No
VC0148
15640179
cell division ATP-binding protein FtsE
233
Conserved Gene / Pathway
Phase 2: March 2008
2PCJ
35.6%
Vibrio cholerae
Cellular processes
Cell division
IDP00036
(
show subtarget assignments
)
1
purified
No
BA_1840
30256110
fibronectin-binding protein, putative
213
Virulence
Phase 1: October 2007
2YB5
32.9%
Bacillus anthracis
Cellular processes
Pathogenesis
IDP01354
(
show subtarget assignments
)
1
cloned
No
VC0003
15640035
trmE
tRNA modification GTPase TrmE
464
Conserved Gene / Pathway
Phase 2: March 2008
3GEH
37.9%
Vibrio cholerae
Cellular processes
Detoxification
IDP01353
(
show subtarget assignments
)
1
expressed
No
VCA0646
15601404
conserved hypothetical protein/hemolysin...
605
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01352
(
show subtarget assignments
)
1
soluble
No
VCA0447
15601210
haemagglutinin associated protein
230
Conserved Gene / Pathway
Phase 2: March 2008
1G60
29.5%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01351
(
show subtarget assignments
)
1
cloned
No
VCA0387
15601150
toxin resistance protein
169
Conserved Gene / Pathway
Phase 2: March 2008
1YVO
31.4%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP01350
(
show subtarget assignments
)
1
in_pdb
3EEV
No
VCA0300
15601065
chloramphenicol acetyltransferase
209
Drug Target Function
Phase 2: March 2008
3EEV
100%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP01349
(
show subtarget assignments
)
1
purified
No
VCA0253
15601021
antibiotic acetyltransferase
232
Drug Target Function
Phase 2: March 2008
3EEV
37.1%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP01348
(
show subtarget assignments
)
0
work_stopped
No
VCA0219
15600988
haemolysin
741
Conserved Gene / Pathway
Phase 2: March 2008
1XEZ
94.7%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01347
(
show subtarget assignments
)
1
purified
No
VC2421
15642418
N-acetyl-anhydromuranmyl-L-alanine amida...
181
Conserved Gene / Pathway
Phase 2: March 2008
1J3G
63%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP01346
(
show subtarget assignments
)
1
cloned
No
VC1621
15641628
agglutination protein
445
Conserved Gene / Pathway
Phase 2: March 2008
2VDD
24.9%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01345
(
show subtarget assignments
)
1
soluble
No
VC0824
15640841
tpx
tagD protein
164
Conserved Gene / Pathway
Phase 2: March 2008
1QXH
50%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01342
(
show subtarget assignments
)
1
soluble
No
VC1960
15641962
septum site-determining protein MinD
276
Conserved Gene / Pathway
Phase 2: March 2008
3Q9L
73.6%
Vibrio cholerae
Cellular processes
Cell division
IDP00151
(
show subtarget assignments
)
1
purified
No
VC0403
15640430
mshM
MSHA biogenesis protein MshM
281
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01339
(
show subtarget assignments
)
1
purified
No
VC2397
15642394
cell division protein FtsZ
398
Conserved Gene / Pathway
Phase 2: March 2008
2VAW
58.6%
Vibrio cholerae
Cellular processes
Cell division
IDP00678
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1624
57286146
era
GTP-binding protein Era
299
Conserved Gene / Pathway
Phase 2: March 2008
3IEV
45.2%
Staphylococcus aureus
Cellular processes
Cell division
IDP00150
(
show subtarget assignments
)
1
purified
No
VC0402
15640429
mshL
MSHA biogenesis protein MshL
559
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01330
(
show subtarget assignments
)
1
purified
No
VC0557
15640579
S-ribosylhomocysteinase
172
Conserved Gene / Pathway
Phase 2: March 2008
1J6W
71.5%
Vibrio cholerae
Cellular processes
Other
IDP01328
(
show subtarget assignments
)
1
purified
No
VC0443
15640470
ksgA
dimethyladenosine transferase
282
Conserved Gene / Pathway
Phase 2: March 2008
3TPZ
61.7%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP01327
(
show subtarget assignments
)
1
purified
No
VC0418
15640445
maf
Maf-like protein
205
Conserved Gene / Pathway
Phase 2: March 2008
1EX2
40%
Vibrio cholerae
Cellular processes
Cell division
IDP04205
(
show subtarget assignments
)
1
soluble
No
CPF_2805
110801373
spoVT
stage V sprulation protein T [Clostridiu...
182
conserved gene; putative drug target function;
Phase 4: April 2009
2W1T
63.9%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP01325
(
show subtarget assignments
)
1
in_pdb
3EER
3I07
3LUS
Yes
VCA1006
15601759
organic hydroperoxide resistance protein...
145
Conserved Gene / Pathway
Phase 2: March 2008
3EER
100%
Vibrio cholerae
Cellular processes
Detoxification
IDP02677
(
show subtarget assignments
)
1
cloned
No
FTT0879
56707983
sodC
superoxide dismuate (Cu-Zn) precusor [Fr...
185
Drug Target
Phase 3: June 2008
1EQW
50.3%
Francisella tularensis
Cellular processes
Detoxification
IDP01322
(
show subtarget assignments
)
1
purified
No
VC2296
15642294
bolA protein
106
Conserved Gene / Pathway
Phase 2: March 2008
2DHM
50.9%
Vibrio cholerae
Cellular processes
Other
IDP00669
(
show subtarget assignments
)
1
cloned
No
SACOL1199
57285942
ftsZ
cell division protein FtsZ
390
Drug Target Function
Phase 2: March 2008
2VAM
68.7%
Staphylococcus aureus
Cellular processes
Cell division
IDP00072
(
show subtarget assignments
)
1
purified
No
NT01ST2585
16420605
hisB
imidazole glycerol-phosphate dehydratase...
355
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2FPR
43.1%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP01318
(
show subtarget assignments
)
1
in_pdb
3IQ1
No
VC0139
15640170
DPS family protein
156
Conserved Gene / Pathway
Phase 2: March 2008
3IQ1
100%
Vibrio cholerae
Cellular processes
Adaptations to atypical conditions
IDP01314
(
show subtarget assignments
)
1
cloned
No
VCA0594
15601353
hemolysin
93
Virulence Associated Factor
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01313
(
show subtarget assignments
)
1
purified
No
VCA0446
15601209
haemagglutinin
63
Virulence Associated Factor
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00037
(
show subtarget assignments
)
0
work_stopped
No
BA_1887
30256548
enterotoxin
386
Virulence
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Toxin production and resistance
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