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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 22 of 60, showing 100 records out of 5973 total, starting on record 2101
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02273
(
show subtarget assignments
)
1
expressed
No
GBAA3714
47528998
hypothetical protein GBAA3714 [Bacillus ...
315
Conserved; Essential;
Phase 3: June 2008
3CCF
14.3%
Bacillus anthracis
Hypothetical proteins
Domain
IDP04031
(
show subtarget assignments
)
1
cloned
No
CBU_A0011
29648123
hypothetical protein CBUA0011 [Coxiella ...
56
drug target;
Phase 4: April 2009
Coxiella burnetii
Hypothetical proteins
Domain
IDP02246
(
show subtarget assignments
)
1
expressed
No
FTT0649c
56707771
rnfB
Iron-sulfur cluster-binding protein [Fra...
209
Drug Target
Phase 3: June 2008
1GT8
12.9%
Francisella tularensis
Energy metabolism
Electron transport
IDP02664
(
show subtarget assignments
)
1
purified
No
GBAA5387
47778397
trxB
thioredoxin reductase [Bacillus anthraci...
318
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
2Q7V
47.5%
Bacillus anthracis
Energy metabolism
Electron transport
IDP01082
(
show subtarget assignments
)
1
expressed
No
STM4279
16767529
nrfC
putative formate-dependent nitrite reduc...
223
Essential Gene
Phase 2: March 2008
2VPW
35.9%
Salmonella enterica
Energy metabolism
Electron transport
IDP02178
(
show subtarget assignments
)
1
soluble
No
FTT0032
56707212
nuoB
NADH dehydrogenase subunit B [Francisell...
158
Drug Target
Phase 3: June 2008
2FUG
53.2%
Francisella tularensis
Energy metabolism
Electron transport
IDP02172
(
show subtarget assignments
)
1
cloned
No
YPO0893
16121198
fldB
flavodoxin FldB [Yersinia pestis CO92]
172
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1FLV
46.5%
Yersinia pestis
Energy metabolism
Electron transport
IDP00562
(
show subtarget assignments
)
1
purified
No
YPO2908
16123099
hmp
nitric oxide dioxygenase
396
Virulence Associated Factor
Phase 2: March 2008
1GVH
63.1%
Yersinia pestis
Energy metabolism
Electron transport
IDP02152
(
show subtarget assignments
)
1
soluble
No
FTT0955c
56708049
gor
glutathione reductase [Francisella tular...
453
Conserved; Drug target functions
Phase 3: June 2008
1GER
49.2%
Francisella tularensis
Energy metabolism
Electron transport
IDP02084
(
show subtarget assignments
)
1
in_crystallization_trials
No
Cj0639c
15791999
adk
adenylate kinase [Campylobacter jejuni s...
192
Possible Vaccine Candidate; Predicted Essential-Modeling
Phase 3: June 2008
1P4S
34.9%
Campylobacter jejuni
Energy metabolism
Electron transport
IDP02072
(
show subtarget assignments
)
1
soluble
No
FTT0554
56707684
hypothetical protein FTT0554 [Francisell...
90
Drug Target
Phase 3: June 2008
4ADZ
35.6%
Francisella tularensis
Energy metabolism
Electron transport
IDP04295
(
show subtarget assignments
)
1
cloned
No
FTT0031
56707211
nuoA
NADH dehydrogenase I, A subunit [Francis...
132
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3RKO
33.3%
Francisella tularensis
Energy metabolism
Electron transport
IDP02734
(
show subtarget assignments
)
1
cloned
No
GBAA1779
47527069
thioredoxin family protein [Bacillus ant...
184
Drug target motif; Drug target functions
Phase 3: June 2008
1ST9
27.7%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02003
(
show subtarget assignments
)
1
cloned
No
YPO0190
16120529
glutathione-regulated potassium-efflux s...
183
Conserved; CD; Involved in virulence; Drug target functions
Phase 3: June 2008
3EYW
38.3%
Yersinia pestis
Energy metabolism
Electron transport
IDP00983
(
show subtarget assignments
)
1
cloned
No
STM2064
16765394
phsB
thiosulfate reductase electron transport...
192
Conserved Gene / Pathway
Phase 2: March 2008
2VPW
37%
Salmonella enterica
Energy metabolism
Electron transport
IDP01979
(
show subtarget assignments
)
1
purified
No
STM3458
16766747
yheR
glutathione-regulated potassium-efflux s...
183
Conserved; Drug target functions
Phase 3: June 2008
3EYW
37.2%
Salmonella enterica
Energy metabolism
Electron transport
IDP01965
(
show subtarget assignments
)
1
cloned
No
STM1786
16765127
hydrogenase-1 small subunit [Salmonella ...
372
Conserved; Drug target functions
Phase 3: June 2008
3UQY
80.9%
Salmonella enterica
Energy metabolism
Electron transport
IDP00961
(
show subtarget assignments
)
1
expressed
No
STM1385
16764735
ttrB
tetrathionate reductase complex subunit ...
250
Conserved Gene / Pathway
Phase 2: March 2008
2VPW
34.4%
Salmonella enterica
Energy metabolism
Electron transport
IDP00948
(
show subtarget assignments
)
1
expressed
No
STM1060
16764419
putative iron-sulfur protein
369
Conserved Gene / Pathway
Phase 2: March 2008
1ROE
8.4%
Salmonella enterica
Energy metabolism
Electron transport
IDP02519
(
show subtarget assignments
)
1
cloned
No
GBAA1494
47526768
resA
thiol-disulfide oxidoreductase [Bacillus...
173
Conserved; Drug target functions
Phase 3: June 2008
1ST9
41.6%
Bacillus anthracis
Energy metabolism
Electron transport
IDP01886
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM0085
16763475
yabF
glutathione-regulated potassium-efflux s...
176
Conserved; Drug target functions
Phase 3: June 2008
3EYW
87.5%
Salmonella enterica
Energy metabolism
Electron transport
IDP01857
(
show subtarget assignments
)
1
soluble
No
FTT1034c
56708121
ndh
NADH dehydrogenase [Francisella tularens...
420
Drug Target
Phase 3: June 2008
1XHC
21%
Francisella tularensis
Energy metabolism
Electron transport
IDP00484
(
show subtarget assignments
)
1
cloned
No
YPO1417
16121697
putative iron-sulfur binding protein
370
Conserved Gene / Pathway
Phase 2: March 2008
2PIA
7%
Yersinia pestis
Energy metabolism
Electron transport
IDP00891
(
show subtarget assignments
)
0
work_stopped
No
STM3816
16767101
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP01812
(
show subtarget assignments
)
1
cloned
No
FTT1764c
56708759
ferredoxin [Francisella tularensis subsp...
107
Conserved; Drug target functions
Phase 3: June 2008
1A6L
64.5%
Francisella tularensis
Energy metabolism
Electron transport
IDP00470
(
show subtarget assignments
)
1
expressed
No
YPO0367
16120702
putative iron-sulfur cluster-binding pro...
411
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Energy metabolism
Electron transport
IDP02653
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM2840
16766146
anaerobic nitric oxide reductase flavoru...
479
Conserved; Drug target functions
Phase 3: June 2008
1YCF
33.8%
Salmonella enterica
Energy metabolism
Electron transport
IDP01801
(
show subtarget assignments
)
1
in_pdb
3MSZ
3LGC
No
FTT0533c
56707666
grxA
glutaredoxin 1 [Francisella tularensis s...
86
Drug Target
Phase 3: June 2008
3LGC
100%
Francisella tularensis
Energy metabolism
Electron transport
IDP01793
(
show subtarget assignments
)
1
in_pdb
3QDN
No
STM0504
16763884
ybbN
putative thioredoxin protein [Salmonella...
284
Conserved; Drug target functions
Phase 3: June 2008
3QDN
100%
Salmonella enterica
Energy metabolism
Electron transport
IDP01784
(
show subtarget assignments
)
1
expressed
No
STM1383
16764733
ttrA
tetrathionate reductase complex subunit ...
1020
Conserved; Drug target functions
Phase 3: June 2008
2IVF
18.1%
Salmonella enterica
Energy metabolism
Electron transport
IDP02723
(
show subtarget assignments
)
1
cloned
No
FTT0039
56707219
nuoI
NADH dehydrogenase subunit I [Francisell...
162
Conserved; Drug target functions
Phase 3: June 2008
2FUG
33.3%
Francisella tularensis
Energy metabolism
Electron transport
IDP00862
(
show subtarget assignments
)
1
cloned
No
STM2251
16765579
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP02772
(
show subtarget assignments
)
1
purified
No
STM2649
16765969
trxC
thioredoxin 2 [Salmonella typhimurium LT...
139
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3P2A
76.3%
Salmonella enterica
Energy metabolism
Electron transport
IDP00453
(
show subtarget assignments
)
1
purified
No
YPO2969
16123150
putative iron-sulphur protein
189
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Energy metabolism
Electron transport
IDP02769
(
show subtarget assignments
)
1
cloned
No
FTT0304c
56707457
nfnB
dihydropteridine reductase [Francisella ...
217
Drug Target
Phase 3: June 2008
3HZN
45.6%
Francisella tularensis
Energy metabolism
Electron transport
IDP04147
(
show subtarget assignments
)
1
expressed
No
YPO3427
115349055
hofC
putative type II secretion system protei...
399
conserved gene; putative drug target function;
Phase 4: April 2009
2VMA
9.8%
Yersinia pestis
Energy metabolism
Electron transport
IDP02594
(
show subtarget assignments
)
1
soluble
No
STM1539
16764884
putative hydrogenase-1 small subunit [Sa...
367
Conserved; Drug target functions
Phase 3: June 2008
3RGW
66.8%
Salmonella enterica
Energy metabolism
Electron transport
IDP01517
(
show subtarget assignments
)
1
expressed
No
VC1254
15641267
iron-sulfur cluster-binding protein, put...
92
Conserved Gene / Pathway
Phase 2: March 2008
1AWD
26.1%
Vibrio cholerae
Energy metabolism
Electron transport
IDP00416
(
show subtarget assignments
)
1
expressed
No
YPO1212
16121503
2Fe-2S ferredoxin YfaE
85
Conserved Gene / Pathway
Phase 2: March 2008
3AV8
33.3%
Yersinia pestis
Energy metabolism
Electron transport
IDP00411
(
show subtarget assignments
)
1
purified
No
YPO0161
16120504
nirB
nitrite reductase
848
Drug Target Function
Phase 2: March 2008
1D7Y
13.6%
Yersinia pestis
Energy metabolism
Electron transport
IDP04482
(
show subtarget assignments
)
1
in_pdb
3P2A
Yes
YPO3270
218930295
trxC
thioredoxin 2 [Yersinia pestis CO92]
145
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3P2A
100%
Yersinia pestis
Energy metabolism
Electron transport
IDP01459
(
show subtarget assignments
)
1
soluble
No
VC2420
161581987
flavodoxin
172
Conserved Gene / Pathway
Phase 2: March 2008
1AG9
45.3%
Vibrio cholerae
Energy metabolism
Electron transport
IDP01446
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC2099
15642099
flavodoxin FldA
175
Conserved Gene / Pathway
Phase 2: March 2008
1AG9
75.4%
Vibrio cholerae
Energy metabolism
Electron transport
IDP00346
(
show subtarget assignments
)
1
cloned
No
lmo0489
16802532
hypothetical protein lmo0489
664
Drug Target Function
Phase 2: March 2008
3K30
26.6%
Listeria monocytogenes
Energy metabolism
Electron transport
IDP04683
(
show subtarget assignments
)
1
expressed
No
GBAA3269
47528557
iron-sulfur cluster-binding protein [Bac...
470
virulence factor; putative drug target function;
Phase 4: April 2009
Bacillus anthracis
Energy metabolism
Electron transport
IDP01319
(
show subtarget assignments
)
1
soluble
No
VC0312
15640339
fre
FMN reductase
236
Conserved Gene / Pathway
Phase 2: March 2008
1QFJ
48.3%
Vibrio cholerae
Energy metabolism
Electron transport
IDP01316
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC1616
15641624
glutaredoxin, putative
77
Conserved Gene / Pathway
Phase 2: March 2008
2KLX
32.5%
Vibrio cholerae
Energy metabolism
Electron transport
IDP01308
(
show subtarget assignments
)
1
expressed
No
VC1516
15641524
iron-sulfur cluster-binding protein
553
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Energy metabolism
Electron transport
IDP01303
(
show subtarget assignments
)
1
purified
No
VC0573
15640595
ubiquinol--cytochrome c reductase, iron-...
197
Conserved Gene / Pathway
Phase 2: March 2008
2FYN
37.6%
Vibrio cholerae
Energy metabolism
Electron transport
IDP02412
(
show subtarget assignments
)
1
soluble
No
GBAA4760
47530059
etfB
electron transfer flavoprotein, beta sub...
257
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1EFP
38.2%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02409
(
show subtarget assignments
)
1
in_crystallization_trials
No
Cj0883c
15792214
hypothetical protein Cj0883c [Campylobac...
136
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
2Y75
28.7%
Campylobacter jejuni
Energy metabolism
Electron transport
IDP02406
(
show subtarget assignments
)
1
crystallized
No
GBAA2768
47528059
thioredoxin reductase, putative [Bacillu...
301
Conserved; Essential; Drug target functions
Phase 3: June 2008
3FBS
32.1%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02383
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0489c
56707631
trxB
thioredoxin reductase [Francisella tular...
316
Drug Target
Phase 3: June 2008
1CL0
66.8%
Francisella tularensis
Energy metabolism
Electron transport
IDP02353
(
show subtarget assignments
)
1
soluble
No
YPO1374
16121654
trxB
thioredoxin reductase [Yersinia pestis C...
320
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1CL0
85%
Yersinia pestis
Energy metabolism
Electron transport
IDP02685
(
show subtarget assignments
)
1
cloned
No
Cj1027c
15792354
gyrA
DNA gyrase subunit A [Campylobacter jeju...
863
Predicted virulence-Resistance to antibiotics and toxic compounds
Phase 3: June 2008
2WL2
33%
Campylobacter jejuni
Energy metabolism
Electron transport
IDP02436
(
show subtarget assignments
)
1
cloned
No
Cj1418c
15792736
hypothetical protein Cj1418c [Campylobac...
779
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Energy metabolism
Electron transport
IDP02326
(
show subtarget assignments
)
1
purified
No
FTT0976
56708068
trxA2
thioredoxin [Francisella tularensis subs...
108
Drug Target
Phase 3: June 2008
1SYR
41.7%
Francisella tularensis
Energy metabolism
Electron transport
IDP02316
(
show subtarget assignments
)
1
soluble
No
FTT0037
56707217
nuoG
NADH dehydrogenase subunit G [Francisell...
788
Conserved; Drug target functions
Phase 3: June 2008
2FUG
24.2%
Francisella tularensis
Energy metabolism
Electron transport
IDP02304
(
show subtarget assignments
)
1
cloned
No
GBAA0703
47525984
qoxA
quinol oxidase, subunit II [Bacillus ant...
291
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1FFT
33.7%
Bacillus anthracis
Energy metabolism
Electron transport
IDP02299
(
show subtarget assignments
)
1
cloned
No
FTT0034
56707214
nuoD
NADH dehydrogenase subunit D [Francisell...
417
Drug Target
Phase 3: June 2008
2FUG
42.2%
Francisella tularensis
Energy metabolism
Electron transport
IDP02293
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1445
56708487
trxA1
thioredoxin [Francisella tularensis subs...
107
Conserved; Drug target functions
Phase 3: June 2008
2H71
50.5%
Francisella tularensis
Energy metabolism
Electron transport
IDP01834
(
show subtarget assignments
)
1
soluble
No
STM2345
16765672
putative transcriptional regulator [Salm...
339
Conserved; Drug target functions
Phase 3: June 2008
3H5O
33.9%
Salmonella enterica
Energy metabolism
Entner-Doudoroff
IDP00132
(
show subtarget assignments
)
1
purified
No
VC_0288
9654699
VC0288
Vibrio cholerae O1 biovar eltor str. N16...
618
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2GP4
53.9%
Vibrio cholerae
Energy metabolism
Entner-Doudoroff
IDP02336
(
show subtarget assignments
)
1
expressed
No
YPO2533
16122751
edd
phosphogluconate dehydratase [Yersinia p...
625
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
2GP4
63.8%
Yersinia pestis
Energy metabolism
Entner-Doudoroff
IDP02237
(
show subtarget assignments
)
1
in_pdb
3T4X
No
GBAA3440
47528725
short chain dehydrogenase/reductase fami...
264
Conserved; Essential;
Phase 3: June 2008
3T4X
100%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP02230
(
show subtarget assignments
)
1
cloned
No
YPO0829
16121138
putative sulfatase [Yersinia pestis CO92...
517
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
2QZU
40.2%
Yersinia pestis
Unknown function
Enzymes of unknown specificity
IDP01048
(
show subtarget assignments
)
1
in_pdb
3R3S
Yes
STM3157
16766457
yghA
oxidoreductase
294
Conserved Gene / Pathway
Phase 2: March 2008
3R3S
100%
Salmonella enterica
Unknown function
Enzymes of unknown specificity
IDP02656
(
show subtarget assignments
)
1
expressed
No
FTT0558
56707688
short chain dehydrogenase [Francisella t...
203
Drug Target
Phase 3: June 2008
3D7L
41.9%
Francisella tularensis
Unknown function
Enzymes of unknown specificity
IDP02802
(
show subtarget assignments
)
1
cloned
No
GBAA3471
47528757
short chain dehydrogenase/reductase fami...
234
Conserved; Essential;
Phase 3: June 2008
1SNY
26.8%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP01001
(
show subtarget assignments
)
1
soluble
No
STM2405
16765731
indolepyruvate decarboxylase
550
Conserved Gene / Pathway
Phase 2: March 2008
1OVM
66.7%
Salmonella enterica
Unknown function
Enzymes of unknown specificity
IDP00957
(
show subtarget assignments
)
0
work_stopped
No
STM1202
16764557
ycfH
predicted metallodependent hydrolase
265
Conserved Gene / Pathway
Phase 2: March 2008
1YIX
92.8%
Salmonella enterica
Unknown function
Enzymes of unknown specificity
IDP01894
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM0564
16763941
pyridine nucleotide-disulfide oxidoreduc...
441
Conserved; Drug target functions
Phase 3: June 2008
2EQ6
32.7%
Salmonella enterica
Unknown function
Enzymes of unknown specificity
IDP01873
(
show subtarget assignments
)
1
cloned
No
FTT0917
56708018
maeA
malate dehydrogenase [Francisella tulare...
604
Drug Target
Phase 3: June 2008
2AW5
34.8%
Francisella tularensis
Unknown function
Enzymes of unknown specificity
IDP01809
(
show subtarget assignments
)
1
purified
No
FTT0258
56707414
carboxylesterase/phospholipase family pr...
222
Drug Target
Phase 3: June 2008
1FJ2
39.6%
Francisella tularensis
Unknown function
Enzymes of unknown specificity
IDP02514
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0116
29540736
mraW
S-adenosyl-methyltransferase MraW [Coxie...
307
Conserved; Drug target functions
Phase 3: June 2008
1WG8
46.9%
Coxiella burnetii
Unknown function
Enzymes of unknown specificity
IDP01786
(
show subtarget assignments
)
1
expressed
No
CBU_0502
29541107
hydrolase, putative [Coxiella burnetii R...
225
Conserved; Drug target functions
Phase 3: June 2008
2GZX
44.9%
Coxiella burnetii
Unknown function
Enzymes of unknown specificity
IDP01780
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM0784
16764148
ybhA
phosphotransferase [Salmonella typhimuri...
272
Conserved; Drug target functions
Phase 3: June 2008
2PQ0
30.5%
Salmonella enterica
Unknown function
Enzymes of unknown specificity
IDP02727
(
show subtarget assignments
)
1
crystallized
No
GBAA4249
47778264
3-hydroxybutyrate dehydrogenase [Bacillu...
258
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
3V2H
42.6%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP00192
(
show subtarget assignments
)
1
cloned
No
YPO0947
16121251
-
putative virulence determinant
3110
Virulence
Phase 1: October 2007
1AF0
2.9%
Yersinia pestis
Unknown function
Enzymes of unknown specificity
IDP00191
(
show subtarget assignments
)
1
cloned
No
YPO0932
16121236
-
conserved hypothetical protein
170
Virulence
Phase 1: October 2007
Yersinia pestis
Unknown function
Enzymes of unknown specificity
IDP01723
(
show subtarget assignments
)
1
in_pdb
3KAX
No
GBAA5138
47530443
aminotransferase, classes I and II [Baci...
383
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
3KAX
100%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP00844
(
show subtarget assignments
)
1
diffraction
No
SACOL0519
57285544
acetyltransferase, GNAT family
174
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP01700
(
show subtarget assignments
)
1
expressed
No
CBU_1899
29542456
methyltransferase, putative [Coxiella bu...
193
Conserved; Drug target functions
Phase 3: June 2008
2FPO
51%
Coxiella burnetii
Unknown function
Enzymes of unknown specificity
IDP00832
(
show subtarget assignments
)
1
in_pdb
3IB3
3III
No
SACOL2612
57286517
hydrolase, CocE/NonD family
560
Drug Target Function
Phase 2: March 2008
3IB3
100%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP01678
(
show subtarget assignments
)
1
cloned
No
GBAA5591
47530913
cardiolipin synthetase domain-containing...
397
Drug target motif; Involved in sporulation;
Phase 3: June 2008
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP01672
(
show subtarget assignments
)
1
soluble
No
GBAA5133
47530438
hypothetical protein GBAA5133 [Bacillus ...
396
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
1DJU
48.2%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP02695
(
show subtarget assignments
)
1
soluble
No
Cj0698
15792047
flgG
flagellar basal body rod protein FlgG [C...
263
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
3A69
23.6%
Campylobacter jejuni
Unknown function
Enzymes of unknown specificity
IDP01640
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA4357
47529653
short chain dehydrogenase/reductase fami...
264
Conserved; Essential;
Phase 3: June 2008
3P19
33.7%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP01639
(
show subtarget assignments
)
1
cloned
No
GBAA4225
47529518
aminotransferase A [Bacillus anthracis s...
387
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
1GD9
39.5%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP01625
(
show subtarget assignments
)
1
expressed
No
FTT1761
56708756
hypothetical protein FTT1761 [Francisell...
239
Drug Target
Phase 3: June 2008
Francisella tularensis
Unknown function
Enzymes of unknown specificity
IDP00778
(
show subtarget assignments
)
1
cloned
No
SACOL0668
57284264
hydrolase, alpha/beta hydrolase fold fam...
266
Drug Target Function
Phase 2: March 2008
1VA4
26.1%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP00773
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL0569
57285587
ATP:guanido phosphotransferase
335
Drug Target Function
Phase 2: March 2008
3L2D
22.7%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP02456
(
show subtarget assignments
)
1
crystallized
No
GBAA3921
47529213
fabG
3-ketoacyl-(acyl-carrier-protein) reduct...
237
Conserved; Essential;
Phase 3: June 2008
2P68
38.1%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP00739
(
show subtarget assignments
)
1
diffraction
No
SACOL1063
57284433
acetyltransferase, GNAT family
144
Drug Target Function
Phase 2: March 2008
1Q2Y
40.3%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP00735
(
show subtarget assignments
)
1
purified
No
SACOL0959
57285833
NADH-dependent flavin oxidoreductase, Oy...
375
Drug Target Function
Phase 2: March 2008
3L5A
30.9%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP00673
(
show subtarget assignments
)
1
expressed
No
SACOL1322
57286057
hydrolase, alpha/beta hydrolase fold fam...
304
Drug Target Function
Phase 2: March 2008
3HJU
24.7%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP00661
(
show subtarget assignments
)
1
purified
No
SACOL0827
57284289
acetyltransferase, putative
161
Drug Target Function
Phase 2: March 2008
1OCX
30.4%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP02573
(
show subtarget assignments
)
1
in_pdb
3ICC
No
GBAA1847
47527139
short chain dehydrogenase [Bacillus anth...
252
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
3ICC
100%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP00649
(
show subtarget assignments
)
1
in_pdb
3R2U
No
SACOL0046
57286601
metallo-beta-lactamase family protein
442
Drug Target Function
Phase 2: March 2008
3R2U
100%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP02826
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA4254
47529547
transaminase [Bacillus anthracis str. 'A...
392
Conserved; Essential; Involved in sporulation;
Phase 3: June 2008
2O1B
40.8%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
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