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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 22 of 60, showing 100 records out of 5973 total, starting on record 2101
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90533
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj0996
15792323
ribA
GTP cyclohydrolase II [Campylobacter jej...
186
Predicted Essential
Community Requests
2BZ0
47.2%
Campylobacter jejuni
IDP91231
(
show subtarget assignments
)
8
soluble
No
NT04EC1793
26108012
ribA
GTP cyclohydrolase II [Escherichia coli ...
196
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2BZ0
99.5%
Escherichia coli
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
IDP91299
(
show subtarget assignments
)
8
cloned
No
STM1711
16765055
ribA
GTP cyclohydrolase II protein
196
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2BZ0
95.4%
Salmonella enterica
IDP91241
(
show subtarget assignments
)
8
soluble
No
HP0802
2313933
GTP cyclohydrolase II (ribA) [Helicobact...
192
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2BZ0
47.7%
Helicobacter pylori
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
IDP91289
(
show subtarget assignments
)
8
soluble
No
SPA1165
56413363
ribA
GTP cyclohydrolase II [Salmonella enteri...
196
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2BZ0
95.4%
Salmonella enterica
IDP90846
(
show subtarget assignments
)
8
in_pdb
4DU6
No
YPO1505
16121778
folE
GTP cyclohydrolase I [Yersinia pestis CO...
220
Predicted Essential
Community Requests
4DU6
100%
Yersinia pestis
IDP02040
(
show subtarget assignments
)
1
expressed
No
GBAA4637
47529935
relA
GTP pyrophosphokinase [Bacillus anthraci...
727
CONSERVED. Additional information: It is responsible for a down-regulation of RN...
Phase 3: June 2008
1VJ7
31.2%
Bacillus anthracis
Cellular processes: Adaptations to atypical conditions
N/A
IDP04269
(
show subtarget assignments
)
1
cloned
No
CPF_2193
110798612
relA
GTP pyrophosphokinase [Clostridium perfr...
726
conserved gene; putative drug target function;
Phase 4: April 2009
1VJ7
28.1%
Clostridium perfringens
Cellular processes
Adaptations to atypical conditions
IDP02827
(
show subtarget assignments
)
1
cloned
No
FTT1508c
56708546
relA
GTP pyrophosphokinase [Francisella tular...
647
Drug Target
Phase 3: June 2008
1VJ7
20.1%
Francisella tularensis
Cellular processes
Adaptations to atypical conditions
IDP01729
(
show subtarget assignments
)
1
cloned
No
FTT0808
56707919
spoT
guanosine-3',5'-bis(diphosphate) 3'-pyro...
707
Conserved; Drug target functions
Phase 3: June 2008
1VJ7
23.6%
Francisella tularensis
Regulatory functionsAmino acid biosynthesis
OtherHistidine family
IDP02139
(
show subtarget assignments
)
1
crystallized
No
GBAA4009
47529302
gmk
guanylate kinase [Bacillus anthracis str...
205
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3TAU
63.9%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides
Nucleotide and nucleoside interconversions
IDP90623
(
show subtarget assignments
)
8
purified
No
Cj1177c
15792501
gmk
guanylate kinase [Campylobacter jejuni s...
207
Predicted Essential
Community Requests
1S96
39.1%
Campylobacter jejuni
IDP05651
(
show subtarget assignments
)
1
soluble
No
Cj1183c
6968610
cfa
guanylate kinase [Campylobacter jejuni s...
387
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1KP9
27.9%
Campylobacter jejuni
Fatty acid and phospholipid metabolism: Biosynthesis
IDP92045
(
show subtarget assignments
)
8
selected
No
TGME49_042730
237834991
guanylate kinase, putative [Toxoplasma g...
346
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1LVG
27.5%
Toxoplasma gondii
IDP90539
(
show subtarget assignments
)
8
crystallized
No
VC2708
15642702
gmk
guanylate kinase [Vibrio cholerae O1 bio...
229
Predicted Essential
Community Requests
1S96
59.8%
Vibrio cholerae
IDP05328
(
show subtarget assignments
)
1
soluble
No
lmo2591
16804629
-
GW repeat-containing surface protein [Li...
508
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1M9S
17.7%
Listeria monocytogenes
Transport and binding proteins: Unknown substrate
IDP01313
(
show subtarget assignments
)
1
purified
No
VCA0446
15601209
haemagglutinin
63
Virulence Associated Factor
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01352
(
show subtarget assignments
)
1
soluble
No
VCA0447
15601210
haemagglutinin associated protein
230
Conserved Gene / Pathway
Phase 2: March 2008
1G60
29.5%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP01348
(
show subtarget assignments
)
0
work_stopped
No
VCA0219
15600988
haemolysin
741
Conserved Gene / Pathway
Phase 2: March 2008
1XEZ
94.7%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00215
(
show subtarget assignments
)
1
cloned
No
YPO2295
16122519
-
haloacid dehalogenase-like hydrolase fam...
224
Virulence
Phase 1: October 2007
3ED5
31.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP91039
(
show subtarget assignments
)
8
selected
No
Sd1012_5151
194431100
hdeB
HdeB protein [Shigella dysenteriae 1012]...
108
potential drug target /
A protein that is important for acid resistance in some enteropathogens; it is a...
Community Requests
2XUV
65.7%
Shigella dysenteriae
IDP91446
(
show subtarget assignments
)
8
expressed
No
VV1_0392
27363860
HD superfamily hydrolase [Vibrio vulnifi...
220
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91712
(
show subtarget assignments
)
8
selected
No
NP_006588
5729877
HSPA8
heat shock cognate 71 kDa protein isofor...
646
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3C7N
85.8%
Homo sapiens
IDP02344
(
show subtarget assignments
)
1
cloned
No
FTT0356
56707508
htpG
heat shock protein 90 [Francisella tular...
628
Conserved; Drug target functions
Phase 3: June 2008
2IOP
52.4%
Francisella tularensis
Cell envelopeProtein fate
Surface structuresProtein folding and stabilization
IDP02393
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1269c
56708329
dnaK
heat shock protein DnaK [Francisella tul...
642
Conserved; Drug target functions
Phase 3: June 2008
2KHO
71.3%
Francisella tularensis
Protein fate
Protein folding and stabilization
IDP00491
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1107
16121407
heat shock protein GrpE
192
Conserved Gene / Pathway
Phase 2: March 2008
1DKG
59.4%
Yersinia pestis
Protein fate
Protein folding and stabilization
IDP01403
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC0854
15640870
heat shock protein GrpE
200
Conserved Gene / Pathway
Phase 2: March 2008
1DKG
39.5%
Vibrio cholerae
Protein fate
Protein folding and stabilization
IDP02284
(
show subtarget assignments
)
1
soluble
No
CBU_1293
29541861
grpE
heat shock protein GrpE [Coxiella burnet...
204
Conserved; Drug target functions
Phase 3: June 2008
1DKG
35.3%
Coxiella burnetii
Protein fate
Protein folding and stabilization
IDP02360
(
show subtarget assignments
)
1
soluble
No
FTT1270c
56708330
grpE
heat shock protein GrpE [Francisella tul...
195
Conserved; Drug target functions
Phase 3: June 2008
1DKG
36.9%
Francisella tularensis
Protein fate
Protein folding and stabilization
IDP01995
(
show subtarget assignments
)
1
soluble
No
CBU_2012
29542567
hslU
heat shock protein HslVU, ATPase subunit...
447
Conserved; Drug target functions
Phase 3: June 2008
1DO0
67.3%
Coxiella burnetii
Protein fate
Protein folding and stabilization
IDP01107
(
show subtarget assignments
)
1
soluble
No
BA_2250
30256894
heat shock protein, Hsp20 family
153
Conserved Gene / Pathway
Phase 2: March 2008
3AAB
24.2%
Bacillus anthracis
Protein fate
Protein folding and stabilization
IDP05040
(
show subtarget assignments
)
1
expressed
No
BA_2262
30256905
heat shock protein, Hsp20 family [Bacill...
145
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1GME
30.3%
Bacillus anthracis
Cellular processes: Adaptations to atypical conditions
IDP01609
(
show subtarget assignments
)
1
crystallized
No
FTT1512c
56708550
dnaJ1
heat shock protein, hsp40 [Francisella t...
308
Conserved; Drug target functions
Phase 3: June 2008
3LZ8
34.2%
Francisella tularensis
Protein fate
Protein folding and stabilization
IDP91935
(
show subtarget assignments
)
8
selected
No
SpneCM_010100001517
298254278
heat shock protein HtpX [Streptococcus p...
299
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3CQB
11.7%
Streptococcus pneumoniae
IDP92125
(
show subtarget assignments
)
8
selected
No
TGME49_057990
237831451
heat shock protein, putative [Toxoplasma...
921
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1QVR
46.4%
Toxoplasma gondii
IDP92130
(
show subtarget assignments
)
8
selected
No
TGME49_061800
237832029
helicase, putative [Toxoplasma gondii ME...
1008
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
IDP02170
(
show subtarget assignments
)
1
soluble
No
FTT1010
56708100
helix-turn-helix family protein [Francis...
67
Drug Target
Phase 3: June 2008
3T75
29.9%
Francisella tularensis
Unknown function
General
IDP00170
(
show subtarget assignments
)
1
soluble
No
VCA0865
15601620
hap
hemagglutinin/protease
609
Virulence
Phase 1: October 2007
1EZM
31.4%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP02222
(
show subtarget assignments
)
1
crystallized
No
lmo0484
16802527
heme-degrading monooxygenase IsdG [Liste...
121
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
1TZ0
28.9%
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP01066
(
show subtarget assignments
)
1
expressed
No
STM3819
16767104
ccmA
heme exporter protein
205
Conserved Gene / Pathway
Phase 2: March 2008
1Z47
32.7%
Salmonella enterica
Protein fate
Protein and peptide secretion and trafficking
IDP00863
(
show subtarget assignments
)
1
expressed
No
STM2254
16765582
ccmA
heme exporter protein
205
Conserved Gene / Pathway
Phase 2: March 2008
1Z47
32.7%
Salmonella enterica
Protein fate
Protein and peptide secretion and trafficking
IDP00408
(
show subtarget assignments
)
1
cloned
No
YPO2735
16122939
ccmB
heme exporter protein B
219
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP00891
(
show subtarget assignments
)
0
work_stopped
No
STM3816
16767101
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP00862
(
show subtarget assignments
)
1
cloned
No
STM2251
16765579
ccmD
heme exporter protein C
70
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Energy metabolism
Electron transport
IDP01781
(
show subtarget assignments
)
1
expressed
No
Cj1616
15792921
chuC
hemin ABC transporter, ATP-binding prote...
258
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
1F3O
31.4%
Campylobacter jejuni
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00565
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0281
16120620
hmuT
hemin-binding periplasmic protein
279
Conserved Gene / Pathway
Phase 2: March 2008
3MD9
91%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP00563
(
show subtarget assignments
)
1
purified
No
YPO0283
16120622
hmuR
hemin receptor precursor
676
Conserved Gene / Pathway
Phase 2: March 2008
3FHH
66.3%
Yersinia pestis
Transport and binding proteins
Other
IDP00552
(
show subtarget assignments
)
1
soluble
No
YPO0282
16120621
hmuS
hemin transport protein
345
Conserved Gene / Pathway
Phase 2: March 2008
2J0R
89.6%
Yersinia pestis
Transport and binding proteins
Unknown substrate
IDP00566
(
show subtarget assignments
)
1
purified
No
YPO0279
16120618
hmuV
hemin transport system ATP-binding prote...
266
Conserved Gene / Pathway
Phase 2: March 2008
3FVQ
30.5%
Yersinia pestis
Transport and binding proteins
Other
IDP00514
(
show subtarget assignments
)
1
selected
No
YPO3721
16123859
hemolysin
1635
Conserved Gene / Pathway
Phase 2: March 2008
3FY3
9%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP01314
(
show subtarget assignments
)
1
cloned
No
VCA0594
15601353
hemolysin
93
Virulence Associated Factor
Phase 2: March 2008
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00061
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4399
30258896
hemolysin A
279
Virulence
Phase 1: October 2007
3HP7
58.4%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04727
(
show subtarget assignments
)
1
purified
No
CPF_2072
110800396
hemolysin A [Clostridium perfringens ATC...
271
conserved gene; putative drug target function;
Phase 4: April 2009
3HP7
49.8%
Clostridium perfringens
Cellular processes
Toxin production and resistance
IDP00431
(
show subtarget assignments
)
1
selected
No
YPO3720
16123858
shlB
hemolysin activator protein
561
Virulence Associated Factor
Phase 2: March 2008
2QDZ
25%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP05023
(
show subtarget assignments
)
1
expressed
No
BAS2353
49185362
-
hemolysin II, C-terminal [Bacillus anthr...
240
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3ANZ
27.9%
Bacillus anthracis
Cellular processes: Pathogenesis
IDP00648
(
show subtarget assignments
)
1
cloned
No
SACOL2160
57286373
hemolysin III, putative
227
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01485
(
show subtarget assignments
)
1
soluble
No
VCA0220
15600989
hemolysin secretion protein HylB
548
Conserved Gene / Pathway
Phase 2: March 2008
3ZX6
16.4%
Vibrio cholerae
Transport and binding proteins
Other
IDP00515
(
show subtarget assignments
)
1
cloned
No
YPO3922
16124053
hemophore HasA
205
Virulence Associated Factor
Phase 2: March 2008
1B2V
29.8%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91686
(
show subtarget assignments
)
8
selected
No
NP_000236
42741655
MET
hepatocyte growth factor receptor isofor...
1390
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2UZX
51.4%
Homo sapiens
IDP91722
(
show subtarget assignments
)
8
selected
No
NP_112420
14043070
HNRNPA1
heterogeneous nuclear ribonucleoprotein ...
372
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1L3K
52.7%
Homo sapiens
IDP91723
(
show subtarget assignments
)
8
selected
No
NP_112552
14165435
HNRNPK
heterogeneous nuclear ribonucleoprotein ...
463
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1J5K
18.6%
Homo sapiens
IDP01515
(
show subtarget assignments
)
1
in_pdb
3ECT
3NZ2
Yes
VCA0836
15601591
hexapeptide-repeat containing-acetyltran...
192
Drug Target Function
Phase 2: March 2008
3ECT
100%
Vibrio cholerae
Central intermediary metabolism
Other
IDP92067
(
show subtarget assignments
)
8
selected
No
TGME49_069430
237832673
hexaprenyl pyrophosphate synthetase prot...
536
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3APZ
23.9%
Toxoplasma gondii
IDP90297
(
show subtarget assignments
)
8
purified
No
TGME49_065450
211966338
hexokinase [Toxoplasma gondii ME49]
468
Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...
Community Requests
1CZA
34.7%
Toxoplasma gondii
IDP00892
(
show subtarget assignments
)
0
work_stopped
No
STM3881
16767165
rbsD
high-affinity D-ribose transport protein...
139
Conserved Gene / Pathway
Phase 2: March 2008
3DSA
100%
Salmonella enterica
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP02366
(
show subtarget assignments
)
1
expressed
No
YPO2061
16122300
znuA
high-affinity zinc transporter periplasm...
318
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...
Phase 3: June 2008
2OGW
63.5%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP90291
(
show subtarget assignments
)
8
soluble
No
TGME49_081900
211969063
high mobility group (HMG) box domain-con...
880
The newly described histone lysine methyl-transferase KMTox targets histones H4 ...
Community Requests
Toxoplasma gondii
IDP00569
(
show subtarget assignments
)
1
purified
No
YPO4016
16124139
hutH
histidine ammonia-lyase
510
Drug Target Function
Phase 2: March 2008
1GK2
77.5%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP01218
(
show subtarget assignments
)
1
expressed
No
BA_3712
73919984
Histidine ammonia-lyase (Histidase)
505
Drug Target Function
Phase 2: March 2008
1GK2
42%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP04554
(
show subtarget assignments
)
1
cloned
No
STM0791_1_506
16764154
hutH
histidine ammonia-lyase [Salmonella typh...
506
Salmonella essential protein
Phase 4: April 2009
1GK2
76.5%
Salmonella enterica
IDP91948
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000392
298254057
histidine kinase PnpS [Streptococcus pne...
443
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3A0R
19.4%
Streptococcus pneumoniae
IDP04115
(
show subtarget assignments
)
1
expressed
No
STM2352_1_235
16765679
hisM
histidine/lysine/arginine/ornithine tran...
235
Salmonella essential protein
Phase 4: April 2009
3DHW
23.8%
Salmonella enterica
IDP05113
(
show subtarget assignments
)
1
in_pdb
4EGU
No
CD2447
126700064
histidine triad nucleotide-binding prote...
119
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
4EGU
100%
Clostridium difficile
Unknown function: General
IDP91915
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007341
298255399
histidine triad protein PhtA/B [Streptoc...
159
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP01913
(
show subtarget assignments
)
1
cloned
No
GBAA1426
47526698
hisD
histidinol dehydrogenase [Bacillus anthr...
429
Conserved; Drug target functions
Phase 3: June 2008
1K75
39.2%
Bacillus anthracis
Amino acid biosynthesis
Histidine family
IDP90730
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj1598
15792903
hisD
histidinol dehydrogenase [Campylobacter ...
428
Predicted Essential
Community Requests
1K75
59.8%
Campylobacter jejuni
IDP00984
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM2073
16765403
hisC
histidinol-phosphate aminotransferase
359
Conserved Gene / Pathway
Phase 2: March 2008
1FG3
88%
Salmonella enterica
Amino acid biosynthesis
Histidine family
IDP02676
(
show subtarget assignments
)
1
crystallized
No
GBAA1539
47526813
hisC-1
histidinol-phosphate aminotransferase [B...
370
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3FFH
46.2%
Bacillus anthracis
Amino acid biosynthesis
Histidine family
IDP91268
(
show subtarget assignments
)
8
soluble
No
NT05BA2906
49179679
histidinol-phosphate aminotransferase [B...
366
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3FFH
40.2%
Bacillus anthracis
IDP90227
(
show subtarget assignments
)
0
work_stopped
No
BAS1428
49184445
-
Histidinol-phosphate aminotransferase (E...
370
Histidinol phosphate aminotransferase (EC 2.6.1.9) is a key enzyme on the histid...
January 2009
3FFH
46.2%
Bacillus anthracis
IDP04159
(
show subtarget assignments
)
1
cloned
No
VC1134
15641147
histidinol-phosphate aminotransferase [V...
346
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1FG3
59.8%
Vibrio cholerae
Amino acid biosynthesis
Histidine family
IDP90766
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj0765c
15792103
hisS
histidyl-tRNA synthetase [Campylobacter ...
408
Predicted Essential
Community Requests
4E51
39%
Campylobacter jejuni
IDP05687
(
show subtarget assignments
)
1
cloned
No
lmo1520
16803560
hisS
histidyl-tRNA synthetase [Listeria monoc...
425
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1QE0
53.4%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP90628
(
show subtarget assignments
)
8
in_crystallization_trials
No
VC0760
15640779
hisS
histidyl-tRNA synthetase [Vibrio cholera...
422
Predicted Essential
Community Requests
1KMM
74.5%
Vibrio cholerae
IDP90816
(
show subtarget assignments
)
8
soluble
No
YPO2878
16123070
hisS
histidyl-tRNA synthetase [Yersinia pesti...
424
Predicted Essential
Community Requests
1KMM
82.1%
Yersinia pestis
IDP90292
(
show subtarget assignments
)
8
cloned
No
TGGT1_004130
221483205
histone acetyltransferase GCN5, putative...
1169
The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...
Community Requests
1Z4R
8.5%
Toxoplasma gondii
IDP91382
(
show subtarget assignments
)
8
purified
No
VV1_1470
27364854
histone acetyltransferase HPA2 [Vibrio v...
164
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1YX0
18.9%
Vibrio vulnificus
IDP90316
(
show subtarget assignments
)
8
cloned
No
CT_743
3329202
hctA
Histone-Like Developmental Protein [Chla...
125
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00840
(
show subtarget assignments
)
1
purified
No
SACOL1894
57284813
HIT family protein
140
Drug Target Function
Phase 2: March 2008
1Y23
52.1%
Staphylococcus aureus
Unknown function
General
IDP02451
(
show subtarget assignments
)
1
in_pdb
3IMI
No
GBAA1047
47526323
HIT family protein [Bacillus anthracis s...
144
Drug target motif; Involved in sporulation;
Phase 3: June 2008
3IMI
100%
Bacillus anthracis
Unknown function
General
IDP01649
(
show subtarget assignments
)
1
expressed
No
CBU_0796
29541390
HIT family protein [Coxiella burnetii RS...
113
Conserved; Drug target functions
Phase 3: June 2008
1AV5
49.6%
Coxiella burnetii
Unknown function
General
IDP02379
(
show subtarget assignments
)
1
expressed
No
FTT1257
56708319
emrA1
HlyD family secretion protein [Francisel...
340
Conserved; Drug target functions
Phase 3: June 2008
4DK0
22.1%
Francisella tularensis
Cellular processesTransport and binding proteins
Toxin production and resistanceOther
IDP91513
(
show subtarget assignments
)
8
expressed
No
VV2_1516
27367863
HlyD family secretion protein [Vibrio vu...
442
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04152
(
show subtarget assignments
)
1
cloned
No
YPO3919
218930919
HlyD family secretion protein [Yersinia ...
442
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP05235
(
show subtarget assignments
)
1
cloned
No
lmo1532
16803572
ruvB
Holliday junction DNA helicase B [Lister...
335
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3PFI
55.2%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP04216
(
show subtarget assignments
)
1
cloned
No
STM1894_1_336
16765236
ruvB
Holliday junction DNA helicase B [Salmon...
336
Salmonella essential protein
Phase 4: April 2009
1HQC
53%
Salmonella enterica
IDP00067
(
show subtarget assignments
)
1
in_pdb
3PFI
No
NT01CJ1369
6968796
ruvB
holliday junction DNA helicase [Campylob...
335
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3PFI
100%
Campylobacter jejuni
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP02534
(
show subtarget assignments
)
1
cloned
No
GBAA4614
47529912
Holliday junction resolvase-like protein...
137
Conserved;
Phase 3: June 2008
1VHX
70.8%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP00816
(
show subtarget assignments
)
1
in_pdb
4DXE
3F09
Yes
SACOL2061
57284929
acpS
holo-(acyl-carrier-protein) synthase
119
Drug Target Function
Phase 2: March 2008
3F09
100%
Staphylococcus aureus
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01182
(
show subtarget assignments
)
1
in_pdb
3HYK
Yes
BA_0250
61211622
Holo-[acyl-carrier-protein] synthase (Ho...
119
Drug Target Function
Phase 2: March 2008
3HYK
100%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
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