Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02665 (show subtarget assignments)	1	cloned	No	FTT0469	56707611	ksgA	dimethyladenosine transferase [Francisel...	262	Conserved; Drug target functions	Phase 3: June 2008	3TQS	40.8%	Francisella tularensis	Cellular processesProtein synthesis	Toxin production and resistancetRNA and rRNA base modification

IDP02706 (show subtarget assignments)	1	cloned	No	FTT0470	56707612	apaH	diadenosine tetraphosphatase [Francisell...	275	Drug Target	Phase 3: June 2008	2DFJ	37.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02794 (show subtarget assignments)	1	purified	No	FTT0477c	56707619	birA	transcription repressor BirA [Francisell...	260	Conserved; Drug target functions	Phase 3: June 2008	1BIA	25.8%	Francisella tularensis	Protein fate	Protein modification and repair

IDP02294 (show subtarget assignments)	1	cloned	No	FTT0483c	56707625		hypothetical protein FTT0483c [Francisel...	295	Drug Target	Phase 3: June 2008	2YKR	39.7%	Francisella tularensis	Unknown function	General

IDP02383 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0489c	56707631	trxB	thioredoxin reductase [Francisella tular...	316	Drug Target	Phase 3: June 2008	1CL0	66.8%	Francisella tularensis	Energy metabolism	Electron transport

IDP02282 (show subtarget assignments)	1	cloned	No	FTT0491c	56707633	gph	phosphoglycolate phosphatase [Francisell...	224	Drug Target	Phase 3: June 2008	2HSZ	32.6%	Francisella tularensis	Energy metabolism	Sugars

IDP02692 (show subtarget assignments)	1	expressed	No	FTT0503c	56707642	sucD	succinyl-CoA synthetase, alpha subunit [...	290	Conserved; Drug target functions	Phase 3: June 2008	1CQI	75.5%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02187 (show subtarget assignments)	1	purified	No	FTT0504c	56707643	sucC	succinyl-CoA synthetase subunit beta [Fr...	387	Conserved; Drug target functions	Phase 3: June 2008	1CQI	62.8%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02303 (show subtarget assignments)	1	cloned	No	FTT0530c	56707664		DJ-1/PfpI family protein [Francisella tu...	200	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3MGK	50.5%	Francisella tularensis	Unknown function	General

IDP01801 (show subtarget assignments)	1	in_pdb 3MSZ 3LGC	No	FTT0533c	56707666	grxA	glutaredoxin 1 [Francisella tularensis s...	86	Drug Target	Phase 3: June 2008	3LGC	100%	Francisella tularensis	Energy metabolism	Electron transport

IDP02391 (show subtarget assignments)	1	cloned	No	FTT0534c	56707667	nrdA	ribonucleotide-diphosphate reductase sub...	590	Drug Target	Phase 3: June 2008	2WGH	31.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02372 (show subtarget assignments)	1	in_pdb 3P7M	No	FTT0535c	56707668	mdh	lactate dehydrogenase [Francisella tular...	319	Conserved; Drug target functions	Phase 3: June 2008	3P7M	100%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02072 (show subtarget assignments)	1	soluble	No	FTT0554	56707684		hypothetical protein FTT0554 [Francisell...	90	Drug Target	Phase 3: June 2008	4ADZ	35.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP04639 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0556c	56707686	oxyR	oxidative stress transcriptional regulat...	289	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2H98	26.2%	Francisella tularensis	Regulatory functions	DNA interactions

IDP01762 (show subtarget assignments)	1	soluble	No	FTT0557	56707687		AhpC/TSA family protein [Francisella tul...	174	Drug Target	Phase 3: June 2008	1NM3	54%	Francisella tularensis	Cellular processes	Detoxification

IDP02656 (show subtarget assignments)	1	expressed	No	FTT0558	56707688		short chain dehydrogenase [Francisella t...	203	Drug Target	Phase 3: June 2008	3D7L	41.9%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP04640 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0559c	56707689	cmk	cytidylate kinase [Francisella tularensi...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CKE	47.1%	Francisella tularensis

IDP02323 (show subtarget assignments)	1	soluble	No	FTT0560c	56707690	serC	phosphoserine aminotransferase [Francise...	350	Drug Target	Phase 3: June 2008	3QBO	41.1%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism	Aspartate familyOther

IDP02448 (show subtarget assignments)	1	in_pdb 3KD3	No	FTT0568	56707697		hypothetical protein FTT0568 [Francisell...	216	Drug Target	Phase 3: June 2008	3KD3	100%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP02469 (show subtarget assignments)	1	cloned	No	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02324 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0581	56707709	coaD	phosphopantetheine adenylyltransferase [...	162	Conserved; Drug target functions	Phase 3: June 2008	1VLH	50.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02506 (show subtarget assignments)	1	soluble	No	FTT0609	56707734		peptidase, M24 family protein [Francisel...	597	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3CTZ	37.4%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02545 (show subtarget assignments)	1	in_pdb 3P09	No	FTT0611c	56707736		beta-lactamase [Francisella tularensis s...	287	Drug Target	Phase 3: June 2008	3P09	100%	Francisella tularensis	Cellular processes	Toxin production and resistance

IDP02054 (show subtarget assignments)	1	purified	No	FTT0623	56707748	tig	trigger factor [Francisella tularensis s...	438	Conserved; Drug target functions	Phase 3: June 2008	1W26	40.4%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02821 (show subtarget assignments)	1	in_pdb 3P2L	No	FTT0624	56707749	clpP	ATP-dependent Clp protease subunit P [Fr...	201	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3P2L	98.5%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02333 (show subtarget assignments)	1	soluble	No	FTT0625	56707750	clpX	ATP-dependent protease ATP-binding subun...	417	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3HWS	54.7%	Francisella tularensis	Protein fate	Protein folding and stabilizationDegradation of proteins, peptides, and glycopeptides

IDP01644 (show subtarget assignments)	1	cloned	No	FTT0626	56707751	lon	DNA-binding, ATP-dependent protease La [...	774	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3M6A	37.7%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02835 (show subtarget assignments)	1	expressed	No	FTT0631	56707756	hflX	protease, GTP-binding subunit [Francisel...	435	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2QTF	22.8%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02639 (show subtarget assignments)	1	soluble	No	FTT0633	56707758	hflK	SPFH domain-containing protein/band 7 fa...	355	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008			Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02751 (show subtarget assignments)	1	expressed	No	FTT0634	56707759	hflC	SPFH domain-containing protein/band 7 fa...	308	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3BK6	13.6%	Francisella tularensis	Protein fateRegulatory functions	Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP02246 (show subtarget assignments)	1	expressed	No	FTT0649c	56707771	rnfB	Iron-sulfur cluster-binding protein [Fra...	209	Drug Target	Phase 3: June 2008	1GT8	12.9%	Francisella tularensis	Energy metabolism	Electron transport

IDP02752 (show subtarget assignments)	1	crystallized	No	FTT0650c	56707772	grxB	glutaredoxin 2 [Francisella tularensis s...	214	Drug Target	Phase 3: June 2008	3IR4	30.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP02554 (show subtarget assignments)	1	cloned	No	FTT0653	56707775	lipA	lipoyl synthase [Francisella tularensis ...	327	Conserved; Drug target functions	Phase 3: June 2008			Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP02106 (show subtarget assignments)	1	cloned	No	FTT0654	56707776	elbB	isoprenoid biosynthesis protein [Francis...	219	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1OY1	47.5%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02247 (show subtarget assignments)	1	expressed	No	FTT0665c	56707786		aldolase/adducin class II family protein...	201	Drug Target	Phase 3: June 2008	3OCR	32.3%	Francisella tularensis	Unknown function	General

IDP04134 (show subtarget assignments)	1	expressed	No	FTT0666c	56707787		methylpurine-DNA glycosylase family prot...	193	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BNK	39.7%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP01620 (show subtarget assignments)	1	cloned	No	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02114 (show subtarget assignments)	1	purified	No	FTT0688c	56707808	hslV	ATP-dependent protease peptidase subunit...	183	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1G3I	59.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP04641 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0693c	56707813	mutM	formamidopyrimidine-DNA glycosylase [Fra...	274	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K82	43.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP02787 (show subtarget assignments)	1	cloned	No	FTT0697	56707817	ftsI	penicillin binding protein (peptidoglyca...	564	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3OC2	37.9%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02814 (show subtarget assignments)	1	cloned	No	FTT0709	56707828	eno	enolase (2-phosphoglycerate dehydratase)...	456	Conserved; Drug target functions	Phase 3: June 2008	1IYX	60.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00339 (show subtarget assignments)	1	expressed	No	FTT0711	56707830	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	229	Drug Target Function	Phase 2: March 2008	1H3M	37.1%	Francisella tularensis

IDP02561 (show subtarget assignments)	1	purified	No	FTT0714c	56707833	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	398	Conserved; Drug target functions	Phase 3: June 2008	1FC4	62.1%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP04642 (show subtarget assignments)	1	expressed	No	FTT0716	56707835	upp	uracil phosphoribosyltransferase [Franci...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2EHJ	69.2%	Francisella tularensis

IDP01655 (show subtarget assignments)	1	purified	No	FTT0721c	56707839	katG	peroxidase/catalase [Francisella tularen...	741	Drug Target	Phase 3: June 2008	1MWV	53.3%	Francisella tularensis	Cellular processes	Detoxification

IDP02429 (show subtarget assignments)	1	expressed	No	FTT0723c	56707841		Short-chain dehydrogenase/reductase fami...	262	Conserved; Drug target functions	Phase 3: June 2008	4E3Z	35.9%	Francisella tularensis	Energy metabolism	Other

IDP01679 (show subtarget assignments)	1	cloned	No	FTT0738	56707853	yjeF	carbohydrate kinase family protein (YjeF...	514	Conserved; Drug target functions	Phase 3: June 2008	2AX3	28%	Francisella tularensis	Energy metabolism	Sugars

IDP02045 (show subtarget assignments)	1	cloned	No	FTT0749c	56707864		hypothetical protein FTT0749c [Francisel...	328	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3AIM	25.6%	Francisella tularensis	Central intermediary metabolism	Other

IDP01685 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0757	56707872	galU	UTP--glucose-1-phosphate uridylyltransfe...	287	Conserved; Drug target functions	Phase 3: June 2008	2E3D	47.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02254 (show subtarget assignments)	1	cloned	No	FTT0766	56707880	deoD	purine nucleoside phosphorylase [Francis...	240	Drug Target	Phase 3: June 2008	1VHJ	43.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01727 (show subtarget assignments)	1	cloned	No	FTT0769	56707883	secA	preprotein translocase subunit SecA [Fra...	906	Drug Target	Phase 3: June 2008	2FSF	53.4%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP02202 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0774	56707886		hypothetical protein FTT0774 [Francisell...	125	Drug Target	Phase 3: June 2008	3USH	52.8%	Francisella tularensis	Unknown function	General

IDP02542 (show subtarget assignments)	1	in_pdb 3INP	No	FTT0789	56707900	rpe	D-ribulose-phosphate 3-epimerase [Franci...	222	Drug Target	Phase 3: June 2008	3INP	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP01729 (show subtarget assignments)	1	cloned	No	FTT0808	56707919	spoT	guanosine-3',5'-bis(diphosphate) 3'-pyro...	707	Conserved; Drug target functions	Phase 3: June 2008	1VJ7	23.6%	Francisella tularensis	Regulatory functionsAmino acid biosynthesis	OtherHistidine family

IDP01733 (show subtarget assignments)	1	cloned	No	FTT0811c	56707922	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	371	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1F0K	39.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02417 (show subtarget assignments)	1	cloned	No	FTT0812	56707923	gcvH1	glycine cleavage system protein H [Franc...	126	Conserved; Drug target functions	Phase 3: June 2008	1ZKO	40.5%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP01783 (show subtarget assignments)	1	expressed	No	FTT0824	56707935	arsC1	arsenate reductase [Francisella tularens...	117	Drug Target	Phase 3: June 2008	3GKX	25.6%	Francisella tularensis	Unknown function	General

IDP02067 (show subtarget assignments)	1	purified	No	FTT0825c	56707936		hypothetical protein FTT0825c [Francisel...	111	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP02590 (show subtarget assignments)	1	soluble	No	FTT0831c	56707940		OmpA family protein [Francisella tularen...	417	Drug Target	Phase 3: June 2008	2K1S	11%	Francisella tularensis	Cell envelope	Other

IDP02520 (show subtarget assignments)	1	soluble	No	FTT0833	56707942	ispH	IspH protein [Francisella tularensis sub...	318	Drug Target	Phase 3: June 2008	3F7T	51.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02193 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0868c	56707972		arsenical restistance operon repressor [...	121	Drug Target	Phase 3: June 2008	3JTH	22.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP01730 (show subtarget assignments)	1	expressed	No	FTT0871	56707975	gpsA	glycerol-3-phosphate dehydrogenase (NAD(...	332	Conserved; Drug target functions	Phase 3: June 2008	3K96	43.1%	Francisella tularensis	Energy metabolismFatty acid and phospholipid metabolism	AerobicAnaerobic,Biosynthesis

IDP01807 (show subtarget assignments)	1	cloned	No	FTT0873c	56707977	radA	DNA repair protein RadA [Francisella tul...	456	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3K1J	15.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP00338 (show subtarget assignments)	1	cloned	No	FTT0876c	56707980	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1UM0	47.4%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02191 (show subtarget assignments)	1	expressed	No	FTT0878c	56707982	msrB	methionine sulfoxide reductase B [Franci...	170	Drug Target	Phase 3: June 2008	1XM0	47.6%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP02677 (show subtarget assignments)	1	cloned	No	FTT0879	56707983	sodC	superoxide dismuate (Cu-Zn) precusor [Fr...	185	Drug Target	Phase 3: June 2008	1EQW	50.3%	Francisella tularensis	Cellular processes	Detoxification

IDP02679 (show subtarget assignments)	1	cloned	No	FTT0889c	56707990		Type IV pili fiber building block protei...	146	Drug Target	Phase 3: June 2008	3SOJ	76.7%	Francisella tularensis	Cell envelopeCellular processes	Surface structuresPathogenesis

IDP01849 (show subtarget assignments)	1	in_pdb 3L07	No	FTT0892	56707993	folD	methylenetetrahydrofolate dehydrogenase/...	282	Conserved; Drug target functions	Phase 3: June 2008	3L07	100%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Aspartate familyFolic acid

IDP04643 (show subtarget assignments)	1	in_pdb 3M84 3QTY	No	FTT0893	56707994	purM	phosphoribosylaminoimidazole synthetase ...	347	conserved gene;	Phase 4: April 2009	3M84	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04357 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0894	56707995	purCD	fusion protein PurC/PurD [Francisella tu...	770	conserved gene; putative drug target function;	Phase 4: April 2009	2YRW	20.3%	Francisella tularensis

IDP04644 (show subtarget assignments)	1	cloned	No	FTT0895	56707996	purN	phosphoribosylglycinamide formyltransfer...	191	conserved gene;	Phase 4: April 2009	1C2T	40.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04072 (show subtarget assignments)	1	in_pdb 3OOW 3OPQ	No	FTT0896	56707997	purE	phosphoribosylaminoimidazole carboxylase...	163	conserved gene; putative drug target function;	Phase 4: April 2009	3OOW	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04645 (show subtarget assignments)	1	soluble	No	FTT0897	56707998	purK	phosphoribosylaminoimidazole carboxylase...	365	conserved gene; putative drug target function;	Phase 4: April 2009	3AW8	42.7%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02115 (show subtarget assignments)	1	purified	No	FTT0900	56708001		hypothetical protein FTT0900 [Francisell...	123	Drug Target	Community Requests	2GM2	22.8%	Francisella tularensis	Cell envelope	Other

IDP02689 (show subtarget assignments)	1	cloned	No	FTT0903	56708004		hypothetical protein FTT0903 [Francisell...	167	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP01811 (show subtarget assignments)	1	expressed	No	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP02621 (show subtarget assignments)	1	cloned	No	FTT0913	56708014		hypothetical protein FTT0913 [Francisell...	155	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP01850 (show subtarget assignments)	1	cloned	No	FTT0916c	56708017	ribF	riboflavin biosynthesis protein RibF [Fr...	306	Drug Target	Phase 3: June 2008	1MRZ	30.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01873 (show subtarget assignments)	1	cloned	No	FTT0917	56708018	maeA	malate dehydrogenase [Francisella tulare...	604	Drug Target	Phase 3: June 2008	2AW5	34.8%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP01882 (show subtarget assignments)	1	soluble	No	FTT0927	56708027	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	431	Drug Target	Phase 3: June 2008	4E77	58.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02288 (show subtarget assignments)	1	cloned	No	FTT0932	56708030		ROK family protein [Francisella tularens...	283	Drug Target	Phase 3: June 2008	2YHY	29.2%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02289 (show subtarget assignments)	1	in_pdb 3OF5	No	FTT0934c	56708031	bioD	dethiobiotin synthetase [Francisella tul...	225	Conserved; Drug target functions	Phase 3: June 2008	3OF5	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01953 (show subtarget assignments)	1	soluble	No	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01958 (show subtarget assignments)	1	expressed	No	FTT0937c	56708034	bioB	biotin synthase [Francisella tularensis ...	313	Drug Target	Phase 3: June 2008	1R30	49.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP92007 (show subtarget assignments)	8	selected	No	FTT_0941c	56708038		unnamed protein product [Francisella tul...	306	virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...	Community Requests	3AIK	33%	Francisella tularensis

IDP01999 (show subtarget assignments)	1	soluble	No	FTT0942c	56708039	folK	2-amino-4-hydroxy-6-hydroxymethyldihydro...	421	Conserved; Drug target functions	Phase 3: June 2008	3MCM	99.1%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02691 (show subtarget assignments)	1	purified	No	FTT0943c	56708040	folB	dihydroneopterin aldolase [Francisella t...	117	Drug Target	Phase 3: June 2008	1SQL	28.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00337 (show subtarget assignments)	1	expressed	No	FTT0946	56708043	trpG	anthranilate synthase component II	184	Drug Target Function	Phase 2: March 2008	1QDL	40.7%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02690 (show subtarget assignments)	1	cloned	No	FTT0954c	56708048		hypothetical protein FTT0954c [Francisel...	106	Drug Target	Phase 3: June 2008	1Y2I	36.8%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02152 (show subtarget assignments)	1	soluble	No	FTT0955c	56708049	gor	glutathione reductase [Francisella tular...	453	Conserved; Drug target functions	Phase 3: June 2008	1GER	49.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02208 (show subtarget assignments)	1	cloned	No	FTT0964c	56708058	ffh	signal recognition particle protein, Ffh...	458	Conserved; Drug target functions	Phase 3: June 2008	2XXA	59%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP02099 (show subtarget assignments)	1	cloned	No	FTT0972	56708065		ABC transporter, ATP-binding protein [Fr...	249	Conserved; Drug target functions	Phase 3: June 2008	2D3W	57.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01982 (show subtarget assignments)	1	purified	No	FTT0975	56708067		hypothetical protein FTT0975 [Francisell...	229	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP02326 (show subtarget assignments)	1	purified	No	FTT0976	56708068	trxA2	thioredoxin [Francisella tularensis subs...	108	Drug Target	Phase 3: June 2008	1SYR	41.7%	Francisella tularensis	Energy metabolism	Electron transport

IDP02210 (show subtarget assignments)	1	cloned	No	FTT0980	56708072		hypothetical protein FTT0980 [Francisell...	413	Conserved; Drug target functions	Phase 3: June 2008	1FC4	26.4%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02004 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0994c	56708086		MRP like protein [Francisella tularensis...	286	Conserved; Drug target functions	Phase 3: June 2008	2PH1	35.3%	Francisella tularensis	Cellular processes	Cell division

IDP02170 (show subtarget assignments)	1	soluble	No	FTT1010	56708100		helix-turn-helix family protein [Francis...	67	Drug Target	Phase 3: June 2008	3T75	29.9%	Francisella tularensis	Unknown function	General

IDP02002 (show subtarget assignments)	1	in_pdb 4E4Y	No	FTT1014c	56708103		short chain dehydrogenase family protein...	241	Drug Target	Phase 3: June 2008	4E4Y	100%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02217 (show subtarget assignments)	1	purified	No	FTT1018c	56708107	dxs	1-deoxy-D-xylulose-5-phosphate synthase ...	615	Conserved; Drug target functions	Phase 3: June 2008	2O1S	56.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	OtherPyridoxine,Thiamine

IDP02219 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1019c	56708108	guaA	bifunctional GMP synthase/glutamine amid...	516	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1GPM	61.1%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02665
(show subtarget assignments)

1

cloned

No

FTT0469

56707611

ksgA

dimethyladenosine transferase [Francisel...

262

Conserved; Drug target functions

Phase 3: June 2008

3TQS

40.8%

Francisella tularensis

Cellular processesProtein synthesis

Toxin production and resistancetRNA and rRNA base modification

IDP02706
(show subtarget assignments)

1

cloned

No

FTT0470

56707612

apaH

diadenosine tetraphosphatase [Francisell...

275

Drug Target

Phase 3: June 2008

2DFJ

37.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02794
(show subtarget assignments)

1

purified

No

FTT0477c

56707619

birA

transcription repressor BirA [Francisell...

260

Conserved; Drug target functions

Phase 3: June 2008

1BIA

25.8%

Francisella tularensis

Protein fate

Protein modification and repair

IDP02294
(show subtarget assignments)

1

cloned

No

FTT0483c

56707625

hypothetical protein FTT0483c [Francisel...

295

Drug Target

Phase 3: June 2008

2YKR

39.7%

Francisella tularensis

Unknown function

General

IDP02383
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0489c

56707631

trxB

thioredoxin reductase [Francisella tular...

316

Drug Target

Phase 3: June 2008

1CL0

66.8%

Francisella tularensis

Energy metabolism

Electron transport

IDP02282
(show subtarget assignments)

1

cloned

No

FTT0491c

56707633

gph

phosphoglycolate phosphatase [Francisell...

224

Drug Target

Phase 3: June 2008

2HSZ

32.6%

Francisella tularensis

Energy metabolism

Sugars

IDP02692
(show subtarget assignments)

1

expressed

No

FTT0503c

56707642

sucD

succinyl-CoA synthetase, alpha subunit [...

290

Conserved; Drug target functions

Phase 3: June 2008

1CQI

75.5%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02187
(show subtarget assignments)

1

purified

No

FTT0504c

56707643

sucC

succinyl-CoA synthetase subunit beta [Fr...

387

Conserved; Drug target functions

Phase 3: June 2008

1CQI

62.8%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02303
(show subtarget assignments)

1

cloned

No

FTT0530c

56707664

DJ-1/PfpI family protein [Francisella tu...

200

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3MGK

50.5%

Francisella tularensis

Unknown function

General

IDP01801
(show subtarget assignments)

1

in_pdb
3MSZ
3LGC

No

FTT0533c

56707666

grxA

glutaredoxin 1 [Francisella tularensis s...

86

Drug Target

Phase 3: June 2008

3LGC

100%

Francisella tularensis

Energy metabolism

Electron transport

IDP02391
(show subtarget assignments)

1

cloned

No

FTT0534c

56707667

nrdA

ribonucleotide-diphosphate reductase sub...

590

Drug Target

Phase 3: June 2008

2WGH

31.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02372
(show subtarget assignments)

1

in_pdb
3P7M

No

FTT0535c

56707668

mdh

lactate dehydrogenase [Francisella tular...

319

Conserved; Drug target functions

Phase 3: June 2008

3P7M

100%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02072
(show subtarget assignments)

1

soluble

No

FTT0554

56707684

hypothetical protein FTT0554 [Francisell...

90

Drug Target

Phase 3: June 2008

4ADZ

35.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP04639
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0556c

56707686

oxyR

oxidative stress transcriptional regulat...

289

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2H98

26.2%

Francisella tularensis

Regulatory functions

DNA interactions

IDP01762
(show subtarget assignments)

1

soluble

No

FTT0557

56707687

AhpC/TSA family protein [Francisella tul...

174

Drug Target

Phase 3: June 2008

1NM3

54%

Francisella tularensis

Cellular processes

Detoxification

IDP02656
(show subtarget assignments)

1

expressed

No

FTT0558

56707688

short chain dehydrogenase [Francisella t...

203

Drug Target

Phase 3: June 2008

3D7L

41.9%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP04640
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0559c

56707689

cmk

cytidylate kinase [Francisella tularensi...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CKE

47.1%

Francisella tularensis

IDP02323
(show subtarget assignments)

1

soluble

No

FTT0560c

56707690

serC

phosphoserine aminotransferase [Francise...

350

Drug Target

Phase 3: June 2008

3QBO

41.1%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism

Aspartate familyOther

IDP02448
(show subtarget assignments)

1

in_pdb
3KD3

No

FTT0568

56707697

hypothetical protein FTT0568 [Francisell...

216

Drug Target

Phase 3: June 2008

3KD3

100%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP02469
(show subtarget assignments)

1

cloned

No

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02324
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0581

56707709

coaD

phosphopantetheine adenylyltransferase [...

162

Conserved; Drug target functions

Phase 3: June 2008

1VLH

50.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02506
(show subtarget assignments)

1

soluble

No

FTT0609

56707734

peptidase, M24 family protein [Francisel...

597

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3CTZ

37.4%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02545
(show subtarget assignments)

1

in_pdb
3P09

No

FTT0611c

56707736

beta-lactamase [Francisella tularensis s...

287

Drug Target

Phase 3: June 2008

3P09

100%

Francisella tularensis

Cellular processes

Toxin production and resistance

IDP02054
(show subtarget assignments)

1

purified

No

FTT0623

56707748

tig

trigger factor [Francisella tularensis s...

438

Conserved; Drug target functions

Phase 3: June 2008

1W26

40.4%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02821
(show subtarget assignments)

1

in_pdb
3P2L

No

FTT0624

56707749

clpP

ATP-dependent Clp protease subunit P [Fr...

201

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3P2L

98.5%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02333
(show subtarget assignments)

1

soluble

No

FTT0625

56707750

clpX

ATP-dependent protease ATP-binding subun...

417

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3HWS

54.7%

Francisella tularensis

Protein fate

Protein folding and stabilizationDegradation of proteins, peptides, and glycopeptides

IDP01644
(show subtarget assignments)

1

cloned

No

FTT0626

56707751

lon

DNA-binding, ATP-dependent protease La [...

774

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3M6A

37.7%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02835
(show subtarget assignments)

1

expressed

No

FTT0631

56707756

hflX

protease, GTP-binding subunit [Francisel...

435

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2QTF

22.8%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02639
(show subtarget assignments)

1

soluble

No

FTT0633

56707758

hflK

SPFH domain-containing protein/band 7 fa...

355

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02751
(show subtarget assignments)

1

expressed

No

FTT0634

56707759

hflC

SPFH domain-containing protein/band 7 fa...

308

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3BK6

13.6%

Francisella tularensis

Protein fateRegulatory functions

Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP02246
(show subtarget assignments)

1

expressed

No

FTT0649c

56707771

rnfB

Iron-sulfur cluster-binding protein [Fra...

209

Drug Target

Phase 3: June 2008

1GT8

12.9%

Francisella tularensis

Energy metabolism

Electron transport

IDP02752
(show subtarget assignments)

1

crystallized

No

FTT0650c

56707772

grxB

glutaredoxin 2 [Francisella tularensis s...

214

Drug Target

Phase 3: June 2008

3IR4

30.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP02554
(show subtarget assignments)

1

cloned

No

FTT0653

56707775

lipA

lipoyl synthase [Francisella tularensis ...

327

Conserved; Drug target functions

Phase 3: June 2008

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP02106
(show subtarget assignments)

1

cloned

No

FTT0654

56707776

elbB

isoprenoid biosynthesis protein [Francis...

219

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1OY1

47.5%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02247
(show subtarget assignments)

1

expressed

No

FTT0665c

56707786

aldolase/adducin class II family protein...

201

Drug Target

Phase 3: June 2008

3OCR

32.3%

Francisella tularensis

Unknown function

General

IDP04134
(show subtarget assignments)

1

expressed

No

FTT0666c

56707787

methylpurine-DNA glycosylase family prot...

193

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BNK

39.7%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP01620
(show subtarget assignments)

1

cloned

No

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02114
(show subtarget assignments)

1

purified

No

FTT0688c

56707808

hslV

ATP-dependent protease peptidase subunit...

183

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1G3I

59.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP04641
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0693c

56707813

mutM

formamidopyrimidine-DNA glycosylase [Fra...

274

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K82

43.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP02787
(show subtarget assignments)

1

cloned

No

FTT0697

56707817

ftsI

penicillin binding protein (peptidoglyca...

564

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3OC2

37.9%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02814
(show subtarget assignments)

1

cloned

No

FTT0709

56707828

eno

enolase (2-phosphoglycerate dehydratase)...

456

Conserved; Drug target functions

Phase 3: June 2008

1IYX

60.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00339
(show subtarget assignments)

1

expressed

No

FTT0711

56707830

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

229

Drug Target Function

Phase 2: March 2008

1H3M

37.1%

Francisella tularensis

IDP02561
(show subtarget assignments)

1

purified

No

FTT0714c

56707833

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

398

Conserved; Drug target functions

Phase 3: June 2008

1FC4

62.1%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP04642
(show subtarget assignments)

1

expressed

No

FTT0716

56707835

upp

uracil phosphoribosyltransferase [Franci...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2EHJ

69.2%

Francisella tularensis

IDP01655
(show subtarget assignments)

1

purified

No

FTT0721c

56707839

katG

peroxidase/catalase [Francisella tularen...

741

Drug Target

Phase 3: June 2008

1MWV

53.3%

Francisella tularensis

Cellular processes

Detoxification

IDP02429
(show subtarget assignments)

1

expressed

No

FTT0723c

56707841

Short-chain dehydrogenase/reductase fami...

262

Conserved; Drug target functions

Phase 3: June 2008

4E3Z

35.9%

Francisella tularensis

Energy metabolism

Other

IDP01679
(show subtarget assignments)

1

cloned

No

FTT0738

56707853

yjeF

carbohydrate kinase family protein (YjeF...

514

Conserved; Drug target functions

Phase 3: June 2008

2AX3

28%

Francisella tularensis

Energy metabolism

Sugars

IDP02045
(show subtarget assignments)

1

cloned

No

FTT0749c

56707864

hypothetical protein FTT0749c [Francisel...

328

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3AIM

25.6%

Francisella tularensis

Central intermediary metabolism

Other

IDP01685
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0757

56707872

galU

UTP--glucose-1-phosphate uridylyltransfe...

287

Conserved; Drug target functions

Phase 3: June 2008

2E3D

47.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02254
(show subtarget assignments)

1

cloned

No

FTT0766

56707880

deoD

purine nucleoside phosphorylase [Francis...

240

Drug Target

Phase 3: June 2008

1VHJ

43.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01727
(show subtarget assignments)

1

cloned

No

FTT0769

56707883

secA

preprotein translocase subunit SecA [Fra...

906

Drug Target

Phase 3: June 2008

2FSF

53.4%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP02202
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0774

56707886

hypothetical protein FTT0774 [Francisell...

125

Drug Target

Phase 3: June 2008

3USH

52.8%

Francisella tularensis

Unknown function

General

IDP02542
(show subtarget assignments)

1

in_pdb
3INP

No

FTT0789

56707900

rpe

D-ribulose-phosphate 3-epimerase [Franci...

222

Drug Target

Phase 3: June 2008

3INP

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP01729
(show subtarget assignments)

1

cloned

No

FTT0808

56707919

spoT

guanosine-3',5'-bis(diphosphate) 3'-pyro...

707

Conserved; Drug target functions

Phase 3: June 2008

1VJ7

23.6%

Francisella tularensis

Regulatory functionsAmino acid biosynthesis

OtherHistidine family

IDP01733
(show subtarget assignments)

1

cloned

No

FTT0811c

56707922

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

371

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1F0K

39.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02417
(show subtarget assignments)

1

cloned

No

FTT0812

56707923

gcvH1

glycine cleavage system protein H [Franc...

126

Conserved; Drug target functions

Phase 3: June 2008

1ZKO

40.5%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP01783
(show subtarget assignments)

1

expressed

No

FTT0824

56707935

arsC1

arsenate reductase [Francisella tularens...

117

Drug Target

Phase 3: June 2008

3GKX

25.6%

Francisella tularensis

Unknown function

General

IDP02067
(show subtarget assignments)

1

purified

No

FTT0825c

56707936

hypothetical protein FTT0825c [Francisel...

111

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP02590
(show subtarget assignments)

1

soluble

No

FTT0831c

56707940

OmpA family protein [Francisella tularen...

417

Drug Target

Phase 3: June 2008

2K1S

11%

Francisella tularensis

Cell envelope

Other

IDP02520
(show subtarget assignments)

1

soluble

No

FTT0833

56707942

ispH

IspH protein [Francisella tularensis sub...

318

Drug Target

Phase 3: June 2008

3F7T

51.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02193
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0868c

56707972

arsenical restistance operon repressor [...

121

Drug Target

Phase 3: June 2008

3JTH

22.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP01730
(show subtarget assignments)

1

expressed

No

FTT0871

56707975

gpsA

glycerol-3-phosphate dehydrogenase (NAD(...

332

Conserved; Drug target functions

Phase 3: June 2008

3K96

43.1%

Francisella tularensis

Energy metabolismFatty acid and phospholipid metabolism

AerobicAnaerobic,Biosynthesis

IDP01807
(show subtarget assignments)

1

cloned

No

FTT0873c

56707977

radA

DNA repair protein RadA [Francisella tul...

456

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3K1J

15.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP00338
(show subtarget assignments)

1

cloned

No

FTT0876c

56707980

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1UM0

47.4%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02191
(show subtarget assignments)

1

expressed

No

FTT0878c

56707982

msrB

methionine sulfoxide reductase B [Franci...

170

Drug Target

Phase 3: June 2008

1XM0

47.6%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP02677
(show subtarget assignments)

1

cloned

No

FTT0879

56707983

sodC

superoxide dismuate (Cu-Zn) precusor [Fr...

185

Drug Target

Phase 3: June 2008

1EQW

50.3%

Francisella tularensis

Cellular processes

Detoxification

IDP02679
(show subtarget assignments)

1

cloned

No

FTT0889c

56707990

Type IV pili fiber building block protei...

146

Drug Target

Phase 3: June 2008

3SOJ

76.7%

Francisella tularensis

Cell envelopeCellular processes

Surface structuresPathogenesis

IDP01849
(show subtarget assignments)

1

in_pdb
3L07

No

FTT0892

56707993

folD

methylenetetrahydrofolate dehydrogenase/...

282

Conserved; Drug target functions

Phase 3: June 2008

3L07

100%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Aspartate familyFolic acid

IDP04643
(show subtarget assignments)

1

in_pdb
3M84
3QTY

No

FTT0893

56707994

purM

phosphoribosylaminoimidazole synthetase ...

347

conserved gene;

Phase 4: April 2009

3M84

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04357
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0894

56707995

purCD

fusion protein PurC/PurD [Francisella tu...

770

conserved gene; putative drug target function;

Phase 4: April 2009

2YRW

20.3%

Francisella tularensis

IDP04644
(show subtarget assignments)

1

cloned

No

FTT0895

56707996

purN

phosphoribosylglycinamide formyltransfer...

191

conserved gene;

Phase 4: April 2009

1C2T

40.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04072
(show subtarget assignments)

1

in_pdb
3OOW
3OPQ

No

FTT0896

56707997

purE

phosphoribosylaminoimidazole carboxylase...

163

conserved gene; putative drug target function;

Phase 4: April 2009

3OOW

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04645
(show subtarget assignments)

1

soluble

No

FTT0897

56707998

purK

phosphoribosylaminoimidazole carboxylase...

365

conserved gene; putative drug target function;

Phase 4: April 2009

3AW8

42.7%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02115
(show subtarget assignments)

1

purified

No

FTT0900

56708001

hypothetical protein FTT0900 [Francisell...

123

Drug Target

Community Requests

2GM2

22.8%

Francisella tularensis

Cell envelope

Other

IDP02689
(show subtarget assignments)

1

cloned

No

FTT0903

56708004

hypothetical protein FTT0903 [Francisell...

167

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP01811
(show subtarget assignments)

1

expressed

No

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP02621
(show subtarget assignments)

1

cloned

No

FTT0913

56708014

hypothetical protein FTT0913 [Francisell...

155

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP01850
(show subtarget assignments)

1

cloned

No

FTT0916c

56708017

ribF

riboflavin biosynthesis protein RibF [Fr...

306

Drug Target

Phase 3: June 2008

1MRZ

30.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01873
(show subtarget assignments)

1

cloned

No

FTT0917

56708018

maeA

malate dehydrogenase [Francisella tulare...

604

Drug Target

Phase 3: June 2008

2AW5

34.8%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP01882
(show subtarget assignments)

1

soluble

No

FTT0927

56708027

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

431

Drug Target

Phase 3: June 2008

4E77

58.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02288
(show subtarget assignments)

1

cloned

No

FTT0932

56708030

ROK family protein [Francisella tularens...

283

Drug Target

Phase 3: June 2008

2YHY

29.2%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02289
(show subtarget assignments)

1

in_pdb
3OF5

No

FTT0934c

56708031

bioD

dethiobiotin synthetase [Francisella tul...

225

Conserved; Drug target functions

Phase 3: June 2008

3OF5

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01953
(show subtarget assignments)

1

soluble

No

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01958
(show subtarget assignments)

1

expressed

No

FTT0937c

56708034

bioB

biotin synthase [Francisella tularensis ...

313

Drug Target

Phase 3: June 2008

1R30

49.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP92007
(show subtarget assignments)

8

selected

No

FTT_0941c

56708038

unnamed protein product [Francisella tul...

306

virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...

Community Requests

3AIK

33%

Francisella tularensis

IDP01999
(show subtarget assignments)

1

soluble

No

FTT0942c

56708039

folK

2-amino-4-hydroxy-6-hydroxymethyldihydro...

421

Conserved; Drug target functions

Phase 3: June 2008

3MCM

99.1%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02691
(show subtarget assignments)

1

purified

No

FTT0943c

56708040

folB

dihydroneopterin aldolase [Francisella t...

117

Drug Target

Phase 3: June 2008

1SQL

28.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00337
(show subtarget assignments)

1

expressed

No

FTT0946

56708043

trpG

anthranilate synthase component II

184

Drug Target Function

Phase 2: March 2008

1QDL

40.7%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02690
(show subtarget assignments)

1

cloned

No

FTT0954c

56708048

hypothetical protein FTT0954c [Francisel...

106

Drug Target

Phase 3: June 2008

1Y2I

36.8%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02152
(show subtarget assignments)

1

soluble

No

FTT0955c

56708049

gor

glutathione reductase [Francisella tular...

453

Conserved; Drug target functions

Phase 3: June 2008

1GER

49.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02208
(show subtarget assignments)

1

cloned

No

FTT0964c

56708058

ffh

signal recognition particle protein, Ffh...

458

Conserved; Drug target functions

Phase 3: June 2008

2XXA

59%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP02099
(show subtarget assignments)

1

cloned

No

FTT0972

56708065

ABC transporter, ATP-binding protein [Fr...

249

Conserved; Drug target functions

Phase 3: June 2008

2D3W

57.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01982
(show subtarget assignments)

1

purified

No

FTT0975

56708067

hypothetical protein FTT0975 [Francisell...

229

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP02326
(show subtarget assignments)

1

purified

No

FTT0976

56708068

trxA2

thioredoxin [Francisella tularensis subs...

108

Drug Target

Phase 3: June 2008

1SYR

41.7%

Francisella tularensis

Energy metabolism

Electron transport

IDP02210
(show subtarget assignments)

1

cloned

No

FTT0980

56708072

hypothetical protein FTT0980 [Francisell...

413

Conserved; Drug target functions

Phase 3: June 2008

1FC4

26.4%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02004
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0994c

56708086

MRP like protein [Francisella tularensis...

286

Conserved; Drug target functions

Phase 3: June 2008

2PH1

35.3%

Francisella tularensis

Cellular processes

Cell division

IDP02170
(show subtarget assignments)

1

soluble

No

FTT1010

56708100

helix-turn-helix family protein [Francis...

67

Drug Target

Phase 3: June 2008

3T75

29.9%

Francisella tularensis

Unknown function

General

IDP02002
(show subtarget assignments)

1

in_pdb
4E4Y

No

FTT1014c

56708103

short chain dehydrogenase family protein...

241

Drug Target

Phase 3: June 2008

4E4Y

100%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02217
(show subtarget assignments)

1

purified

No

FTT1018c

56708107

dxs

1-deoxy-D-xylulose-5-phosphate synthase ...

615

Conserved; Drug target functions

Phase 3: June 2008

2O1S

56.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

OtherPyridoxine,Thiamine

IDP02219
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1019c

56708108

guaA

bifunctional GMP synthase/glutamine amid...

516

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1GPM

61.1%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

Targets