Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00153 (show subtarget assignments)	1	expressed	No	VC0475	15640502	irgA	enterobactin receptor	652	Virulence	Phase 1: October 2007	2HDF	37.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00075 (show subtarget assignments)	0	work_stopped	No	NTL01ST3174	16421824	yraO	putative phosphoheptose isomerase	196		Phase 1: October 2007	2YVA	98%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00152 (show subtarget assignments)	1	in_pdb 3DZC	Yes	VC0917	15640933	wecB	UDP-N-acetylglucosamine 2-epimerase	372	Virulence	Phase 1: October 2007	3DZC	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00151 (show subtarget assignments)	1	purified	No	VC0403	15640430	mshM	MSHA biogenesis protein MshM	281	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00074 (show subtarget assignments)	0	work_stopped	No	NT01ST3685	16421504	pyrG	CTP synthetase	545	Essential	Phase 1: October 2007	1S1M	95%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00037 (show subtarget assignments)	0	work_stopped	No	BA_1887	30256548		enterotoxin	386	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00150 (show subtarget assignments)	1	purified	No	VC0402	15640429	mshL	MSHA biogenesis protein MshL	559	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00149 (show subtarget assignments)	1	expressed	No	VCA0230	15600999	vctC	vibriobactin and enterobactin ABC transp...	254	Virulence	Phase 1: October 2007	2D62	28%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00073 (show subtarget assignments)	1	crystallized	No	NT01ST3324	16421221	rimM	16S rRNA processing protein	182	Essential	Phase 1: October 2007	3H9N	63.2%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00148 (show subtarget assignments)	1	soluble	No	VCA0227	15600996	vctP	vibriobactin and enterobactin ABC transp...	333	Virulence	Phase 1: October 2007	3GFV	30.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00018 (show subtarget assignments)	0	work_stopped	No	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00009 (show subtarget assignments)	1	soluble	No	BA_1538	38372188		3-dehydroquinate synthase	363	Drug Target Homolog	Phase 1: October 2007	1XAG	38.3%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00147 (show subtarget assignments)	1	expressed	No	VC0780	15640799	vibD	vibriobactin synthase component D	261	Virulence	Phase 1: October 2007			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00072 (show subtarget assignments)	1	purified	No	NT01ST2585	16420605	hisB	imidazole glycerol-phosphate dehydratase...	355	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FPR	43.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00036 (show subtarget assignments)	1	purified	No	BA_1840	30256110		fibronectin-binding protein, putative	213	Virulence	Phase 1: October 2007	2YB5	32.9%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP00146 (show subtarget assignments)	1	soluble	No	VC0778	15640797	viuG	vibriobactin and enterobactin ABC transp...	358	Virulence	Phase 1: October 2007	2QI9	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00145 (show subtarget assignments)	1	expressed	No	VC0777	15640796	viuD	vibriobactin and enterobactin ABC transp...	350	Virulence	Phase 1: October 2007	2NQ2	30.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00071 (show subtarget assignments)	0	work_stopped	No	NT01ST2260	16420352	yeaZ	putative molecular chaperone	231	Essential	Phase 1: October 2007	2GEL	100%	Salmonella enterica	Unknown function	General

IDP00144 (show subtarget assignments)	1	soluble	No	VC0776	15640795	viuP	vibriobactin and enterobactin ABC transp...	325	Virulence	Phase 1: October 2007	3R5S	91.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00143 (show subtarget assignments)	1	soluble	No	VC0779	15640798	viuC	vibriobactin and enterobactin ABC transp...	279	Virulence	Phase 1: October 2007	1B0U	29%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00070 (show subtarget assignments)	0	work_stopped	No	NT01ST1465	16419700	flgK	hook-filament junction protein 1	553	Virulence	Phase 1: October 2007	2D4Y	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00035 (show subtarget assignments)	1	soluble	No	BA_1589	30255889		macrolide 2-phosphotransferase, putative...	298	Virulence	Phase 1: October 2007	3LZH	17.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00142 (show subtarget assignments)	1	cloned	No	VC1456	15641467	ctxB	cholera enterotoxin, B subunit	124	Virulence	Phase 1: October 2007	1EEI	81.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00141 (show subtarget assignments)	1	crystallized	No	VC0401	15640428	mshK	MSHA biogenesis protein MshK	105	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00069 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0342	16418853	STM0352	putative cation efflux pump	408	Virulence	Phase 1: October 2007	1T5E	31.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0197	30253704		pyrroline-5-carboxylate reductase, putat...	245	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3TRI	33.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00017 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4333	81581445	ribBA	Riboflavin biosynthesis protein ribBA [I...	397	Drug Target Homolog	Phase 1: October 2007	2BZ0	27%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00139 (show subtarget assignments)	1	crystallized	No	BA_4355	30258855	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1VKN	40.5%	Bacillus anthracis	Unknown function	General

IDP00068 (show subtarget assignments)	0	work_stopped	No	NT01ST0271	16418722	pyrH	uridylate kinase	241	Essential	Phase 1: October 2007	2BNE	97.9%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00138 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4159	30258665		conserved hypothetical protein	95	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ODM	56.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00034 (show subtarget assignments)	1	expressed	No	BA_1346	30255285		internalin, putative	542	Virulence	Phase 1: October 2007	2OMT	21.6%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP00137 (show subtarget assignments)	1	in_crystallization_trials	No	VC_0959	9655418	VC0959	Vibrio cholerae O1 biovar eltor str. N16...	291	Virulence	Phase 1: October 2007	3NQR	29.6%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00067 (show subtarget assignments)	1	in_pdb 3PFI	No	NT01CJ1369	6968796	ruvB	holliday junction DNA helicase [Campylob...	335	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3PFI	100%	Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00134 (show subtarget assignments)	1	purified	No	VC_2250	9656811	VC2250	Vibrio cholerae O1 biovar eltor str. N16...	351	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3EH0	63%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00133 (show subtarget assignments)	1	purified	No	VC_2095	9656644	VC2095	Vibrio cholerae O1 biovar eltor str. N16...	548	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FUV	70.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP00066 (show subtarget assignments)	1	expressed	No	NTL01CJ00766	6968259	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	239	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2Y6P	40.2%	Campylobacter jejuni	Protein synthesis	tRNA aminoacylation

IDP00033 (show subtarget assignments)	1	cloned	No	BA_1295	30255240		immune inhibitor A metalloprotease	795	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00132 (show subtarget assignments)	1	purified	No	VC_0288	9654699	VC0288	Vibrio cholerae O1 biovar eltor str. N16...	618	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GP4	53.9%	Vibrio cholerae	Energy metabolism	Entner-Doudoroff

IDP00131 (show subtarget assignments)	0	work_stopped	No	NT01ST2113	16765046	rnb	exoribonuclease II	644	Essential	Phase 1: October 2007	2ID0	90.7%	Salmonella enterica	Transcription	Degradation of RNA

IDP00065 (show subtarget assignments)	1	expressed	No	BA_5409	30259882		macrolide efflux pump, putative	544	Virulence	Phase 1: October 2007	1YQT	24.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00002 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0079	47566400	-	surface layer protein, (pxo1-54)	404	Drug Target Homolog	Phase 1: October 2007	3PYW	14.4%	Bacillus anthracis

IDP00130 (show subtarget assignments)	1	in_crystallization_trials	No	NT01ST5659	16767805	yjjV	putative deoxyribonuclease YjjV	257	Virulence	Phase 1: October 2007	1ZZM	76.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00016 (show subtarget assignments)	1	crystallized	No	BA_4053	46576983		UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	491	Drug Target Homolog	Phase 1: October 2007	2WTZ	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00008 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1445	30255378	cysG	uroporphyrin-III C-methyltransferase	258	Drug Target Homolog	Phase 1: October 2007	1PJQ	43.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00129 (show subtarget assignments)	0	work_stopped	No	NT01ST3985	16766479	mdaB	NADPH-specific quinone oxidoreductase	193	Virulence	Phase 1: October 2007	2AMJ	91.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00064 (show subtarget assignments)	1	cloned	No	BA_5200	30259683		transcriptional activator tipA, putative...	243	Virulence	Phase 1: October 2007	3QAO	56.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00032 (show subtarget assignments)	1	purified	No	BA_1221	30255171		bacteriocin O-metyltransferase, putative...	281	Virulence	Phase 1: October 2007	2WK1	36.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00004 (show subtarget assignments)	1	soluble	No	BA_0001	38257418		Chromosomal replication initiator protei...	446	Drug Target Homolog	Phase 1: October 2007	2Z4R	37.2%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP00128 (show subtarget assignments)	1	soluble	No	NT01ST3027	16765755	pdxK	mp65f07.r1 Soares_thymus_2NbMT Mus muscu...	288	Essential	Phase 1: October 2007	2DDM	65.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00589 (show subtarget assignments)	1	soluble	No	YPO0954	161486886	mltC	membrane-bound lytic murein transglycosy...	358	Drug Target Function	Phase 2: March 2008	2Y8P	19.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01129 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5296	30259774		ferritin	168	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	48.2%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00588 (show subtarget assignments)	1	purified	No	YPO2077	16122316	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	87.8%	Yersinia pestis	Cellular processes	Cell division

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01126 (show subtarget assignments)	1	cloned	No	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00587 (show subtarget assignments)	1	cloned	No	YPO1507	16121780	mglB	galactose-binding protein	335	Virulence Associated Factor	Phase 2: March 2008	1GCA	80.9%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01124 (show subtarget assignments)	1	purified	No	BA_4938	33301353		UDP-N-acetylmuramate--L-alanine ligase (...	436	Conserved Gene / Pathway	Phase 2: March 2008	1J6U	30.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01123 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4267	30258769	ptsI	phosphoenolpyruvate-protein phosphotrans...	570	Conserved Gene / Pathway	Phase 2: March 2008	2HRO	65.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00586 (show subtarget assignments)	1	purified	No	YPO3789	16123923	metR	lysR-family transcriptional regulatory p...	317	Virulence Associated Factor	Phase 2: March 2008	1AL3	23.7%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01122 (show subtarget assignments)	1	soluble	No	BA_4045	30258552	ftsZ	cell division protein FtsZ	386	Conserved Gene / Pathway	Phase 2: March 2008	2VAM	78.1%	Bacillus anthracis	Cellular processes	Cell division

IDP00585 (show subtarget assignments)	1	expressed	No	YPO0116	16120461	metL	bifunctional aspartate kinase II/homoser...	811	Virulence Associated Factor	Phase 2: March 2008	1EBF	15.5%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01120 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1194	30254907		oligopeptide ABC transporter, ATP-bindin...	347	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01119 (show subtarget assignments)	1	purified	No	BA_0344	30253882	ahpF	alkyl hydroperoxide reductase, F subunit...	508	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	55.7%	Bacillus anthracis	Cellular processes	Detoxification

IDP00584 (show subtarget assignments)	1	soluble	No	YPO0117	16120462	metF	5,10-methylenetetrahydrofolate reductase...	294	Virulence Associated Factor	Phase 2: March 2008	1ZP3	86.4%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01118 (show subtarget assignments)	1	crystallized	No	BA_4030	81837831		Bifunctional protein pyrR [Includes: Pyr...	180	Conserved Gene / Pathway	Phase 2: March 2008	1A3C	73.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00583 (show subtarget assignments)	1	expressed	No	YPO2752	16122956	mepA	penicillin-insensitive murein endopeptid...	275	Drug Target Function	Phase 2: March 2008	1TZP	67.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01117 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3754	33301235		LexA repressor	206	Conserved Gene / Pathway	Phase 2: March 2008	3K2Z	38.3%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP01116 (show subtarget assignments)	1	expressed	No	BA_1693	30255984		glycosyl transferase, group 2 family pro...	150	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01115 (show subtarget assignments)	1	in_pdb 3IG4	No	BA_1901	30256561		xaa-pro aminopeptidase, putative	427	Drug Target Function	Phase 2: March 2008	3IG4	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00582 (show subtarget assignments)	1	in_pdb 3GSE	Yes	YPO2528	16122747	menF	menaquinone-specific isochorismate synth...	455	Conserved Gene / Pathway	Phase 2: March 2008	3GSE	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01114 (show subtarget assignments)	1	soluble	No	BA_4901	38502945		Septation ring formation regulator ezrA	570	Conserved Gene / Pathway	Phase 2: March 2008			Bacillus anthracis	Cellular processes	Cell division

IDP00581 (show subtarget assignments)	1	in_pdb 3RDW	Yes	YPO3070	16123247		putative arsenate reductase	118	Virulence Associated Factor	Phase 2: March 2008	3RDW	100%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01112 (show subtarget assignments)	1	in_pdb 3G48	No	BA_2064	30256713	csaA	chaperone CsaA	109	Conserved Gene / Pathway	Phase 2: March 2008	3G48	99.1%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01111 (show subtarget assignments)	1	cloned	No	BA_1135	49035527		Major cold shock protein cspA	67	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	73.1%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP00580 (show subtarget assignments)	1	purified	No	YPO0059	16120412	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	403	Conserved Gene / Pathway	Phase 2: March 2008	1FC4	82.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01110 (show subtarget assignments)	1	in_pdb 3RYK	Yes	BA_1229	30255178	rfbC	dTDP-4-dehydrorhamnose 3,5-epimerase	181	Conserved Gene / Pathway	Phase 2: March 2008	3RYK	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00579 (show subtarget assignments)	1	cloned	No	YPO1122	16121422	tolR	colicin uptake protein TolR	142	Conserved Gene / Pathway	Phase 2: March 2008	2JWK	23.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01109 (show subtarget assignments)	1	soluble	No	GBAA_pXO1_0148	47566460		hypothetical protein GBAA_pXO1_0148	150	Virulence Associated Factor	Phase 2: March 2008	3PMD	100%	Bacillus anthracis

IDP01108 (show subtarget assignments)	1	in_pdb	No	BA_3860	30258377		copper-ion-binding protein	68	Conserved Gene / Pathway	Phase 2: March 2008	2L3M	100%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01107 (show subtarget assignments)	1	soluble	No	BA_2250	30256894		heat shock protein, Hsp20 family	153	Conserved Gene / Pathway	Phase 2: March 2008	3AAB	24.2%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP00578 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3553	16123697	elbB	isoprenoid biosynthesis protein with ami...	217	Drug Target Function	Phase 2: March 2008	1OY1	63.6%	Yersinia pestis	Unknown function	General

IDP01106 (show subtarget assignments)	1	soluble	No	BA_1846	30256116	msrA-1	peptide methionine sulfoxide reductase	178	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	36%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP00577 (show subtarget assignments)	1	in_pdb 3OYT	Yes	YPO2757	16122961	fabB	3-oxoacyl-(acyl carrier protein) synthas...	407	Virulence Associated Factor	Phase 2: March 2008	3OYT	100%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01105 (show subtarget assignments)	1	purified	No	BA_2788	67460529		ATP-dependent Clp protease proteolytic s...	193	Drug Target Function	Phase 2: March 2008	3TT7	67.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01104 (show subtarget assignments)	1	soluble	No	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01103 (show subtarget assignments)	1	cloned	No	BA_1387	47605671		D-alanine--poly(phosphoribitol) ligase s...	79	Drug Target Function	Phase 2: March 2008	1DV5	45.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00576 (show subtarget assignments)	1	cloned	No	YPO1398	16121678	cspB	cold shock-like protein	69	Virulence Associated Factor	Phase 2: March 2008	3I2Z	50.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP01102 (show subtarget assignments)	1	soluble	No	BA_5424	49040749		Cold shock-like protein cspC	65	Essential Gene	Phase 2: March 2008	1C9O	74.2%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01101 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0119	47566439		hypothetical protein GBAA_pXO1_0119	82	Virulence Associated Factor	Phase 2: March 2008	3SIK	52.4%	Bacillus anthracis

IDP00574 (show subtarget assignments)	1	cloned	No	YPO0531	16120860	leuC	isopropylmalate isomerase large subunit ...	476	Virulence Associated Factor	Phase 2: March 2008	1ACO	25%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP01100 (show subtarget assignments)	1	in_pdb 3K1S	No	BA_5442	30259910	celC-2	PTS system, cellobiose-specific IIA comp...	107	Conserved Gene / Pathway	Phase 2: March 2008	3K1S	99.1%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01091 (show subtarget assignments)	1	in_crystallization_trials	No	STM4578	16767819	serB	phosphoserine phosphatase	322	Conserved Gene / Pathway	Phase 2: March 2008	3N28	47.2%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP00575 (show subtarget assignments)	1	in_pdb 3V4Z	No	YPO0557	16120885	ddl	D-alanine--D-alanine ligase	306	Drug Target Function	Phase 2: March 2008	3V4Z	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01090 (show subtarget assignments)	0	work_stopped	No	STM4567	16767808	deoC	deoxyribose-phosphate aldolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1JCL	94.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP00573 (show subtarget assignments)	1	in_pdb 3GO9	No	YPO3991	16124118		putative insulinase family protease	499	Drug Target Function	Phase 2: March 2008	3GO9	98.6%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01089 (show subtarget assignments)	1	soluble	No	STM4533	16767777	tsr	methyl-accepting chemotaxis protein I	553	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	49.5%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00153
(show subtarget assignments)

1

expressed

No

VC0475

15640502

irgA

enterobactin receptor

652

Virulence

Phase 1: October 2007

2HDF

37.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00075
(show subtarget assignments)

0

work_stopped

No

NTL01ST3174

16421824

yraO

putative phosphoheptose isomerase

196

Phase 1: October 2007

2YVA

98%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00152
(show subtarget assignments)

1

in_pdb
3DZC

Yes

VC0917

15640933

wecB

UDP-N-acetylglucosamine 2-epimerase

372

Virulence

Phase 1: October 2007

3DZC

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00151
(show subtarget assignments)

1

purified

No

VC0403

15640430

mshM

MSHA biogenesis protein MshM

281

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00074
(show subtarget assignments)

0

work_stopped

No

NT01ST3685

16421504

pyrG

CTP synthetase

545

Essential

Phase 1: October 2007

1S1M

95%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00037
(show subtarget assignments)

0

work_stopped

No

BA_1887

30256548

enterotoxin

386

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00150
(show subtarget assignments)

1

purified

No

VC0402

15640429

mshL

MSHA biogenesis protein MshL

559

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00149
(show subtarget assignments)

1

expressed

No

VCA0230

15600999

vctC

vibriobactin and enterobactin ABC transp...

254

Virulence

Phase 1: October 2007

2D62

28%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00073
(show subtarget assignments)

1

crystallized

No

NT01ST3324

16421221

rimM

16S rRNA processing protein

182

Essential

Phase 1: October 2007

3H9N

63.2%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00148
(show subtarget assignments)

1

soluble

No

VCA0227

15600996

vctP

vibriobactin and enterobactin ABC transp...

333

Virulence

Phase 1: October 2007

3GFV

30.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00018
(show subtarget assignments)

0

work_stopped

No

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00009
(show subtarget assignments)

1

soluble

No

BA_1538

38372188

3-dehydroquinate synthase

363

Drug Target Homolog

Phase 1: October 2007

1XAG

38.3%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00147
(show subtarget assignments)

1

expressed

No

VC0780

15640799

vibD

vibriobactin synthase component D

261

Virulence

Phase 1: October 2007

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00072
(show subtarget assignments)

1

purified

No

NT01ST2585

16420605

hisB

imidazole glycerol-phosphate dehydratase...

355

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FPR

43.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00036
(show subtarget assignments)

1

purified

No

BA_1840

30256110

fibronectin-binding protein, putative

213

Virulence

Phase 1: October 2007

2YB5

32.9%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00146
(show subtarget assignments)

1

soluble

No

VC0778

15640797

viuG

vibriobactin and enterobactin ABC transp...

358

Virulence

Phase 1: October 2007

2QI9

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00145
(show subtarget assignments)

1

expressed

No

VC0777

15640796

viuD

vibriobactin and enterobactin ABC transp...

350

Virulence

Phase 1: October 2007

2NQ2

30.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00071
(show subtarget assignments)

0

work_stopped

No

NT01ST2260

16420352

yeaZ

putative molecular chaperone

231

Essential

Phase 1: October 2007

2GEL

100%

Salmonella enterica

Unknown function

General

IDP00144
(show subtarget assignments)

1

soluble

No

VC0776

15640795

viuP

vibriobactin and enterobactin ABC transp...

325

Virulence

Phase 1: October 2007

3R5S

91.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00143
(show subtarget assignments)

1

soluble

No

VC0779

15640798

viuC

vibriobactin and enterobactin ABC transp...

279

Virulence

Phase 1: October 2007

1B0U

29%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00070
(show subtarget assignments)

0

work_stopped

No

NT01ST1465

16419700

flgK

hook-filament junction protein 1

553

Virulence

Phase 1: October 2007

2D4Y

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00035
(show subtarget assignments)

1

soluble

No

BA_1589

30255889

macrolide 2-phosphotransferase, putative...

298

Virulence

Phase 1: October 2007

3LZH

17.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00142
(show subtarget assignments)

1

cloned

No

VC1456

15641467

ctxB

cholera enterotoxin, B subunit

124

Virulence

Phase 1: October 2007

1EEI

81.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00141
(show subtarget assignments)

1

crystallized

No

VC0401

15640428

mshK

MSHA biogenesis protein MshK

105

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00069
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0342

16418853

STM0352

putative cation efflux pump

408

Virulence

Phase 1: October 2007

1T5E

31.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0197

30253704

pyrroline-5-carboxylate reductase, putat...

245

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3TRI

33.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00017
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4333

81581445

ribBA

Riboflavin biosynthesis protein ribBA [I...

397

Drug Target Homolog

Phase 1: October 2007

2BZ0

27%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00139
(show subtarget assignments)

1

crystallized

No

BA_4355

30258855

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1VKN

40.5%

Bacillus anthracis

Unknown function

General

IDP00068
(show subtarget assignments)

0

work_stopped

No

NT01ST0271

16418722

pyrH

uridylate kinase

241

Essential

Phase 1: October 2007

2BNE

97.9%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00138
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4159

30258665

conserved hypothetical protein

95

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ODM

56.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00034
(show subtarget assignments)

1

expressed

No

BA_1346

30255285

internalin, putative

542

Virulence

Phase 1: October 2007

2OMT

21.6%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00137
(show subtarget assignments)

1

in_crystallization_trials

No

VC_0959

9655418

VC0959

Vibrio cholerae O1 biovar eltor str. N16...

291

Virulence

Phase 1: October 2007

3NQR

29.6%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00067
(show subtarget assignments)

1

in_pdb
3PFI

No

NT01CJ1369

6968796

ruvB

holliday junction DNA helicase [Campylob...

335

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3PFI

100%

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00134
(show subtarget assignments)

1

purified

No

VC_2250

9656811

VC2250

Vibrio cholerae O1 biovar eltor str. N16...

351

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3EH0

63%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00133
(show subtarget assignments)

1

purified

No

VC_2095

9656644

VC2095

Vibrio cholerae O1 biovar eltor str. N16...

548

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FUV

70.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP00066
(show subtarget assignments)

1

expressed

No

NTL01CJ00766

6968259

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

239

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2Y6P

40.2%

Campylobacter jejuni

Protein synthesis

tRNA aminoacylation

IDP00033
(show subtarget assignments)

1

cloned

No

BA_1295

30255240

immune inhibitor A metalloprotease

795

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00132
(show subtarget assignments)

1

purified

No

VC_0288

9654699

VC0288

Vibrio cholerae O1 biovar eltor str. N16...

618

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GP4

53.9%

Vibrio cholerae

Energy metabolism

Entner-Doudoroff

IDP00131
(show subtarget assignments)

0

work_stopped

No

NT01ST2113

16765046

rnb

exoribonuclease II

644

Essential

Phase 1: October 2007

2ID0

90.7%

Salmonella enterica

Transcription

Degradation of RNA

IDP00065
(show subtarget assignments)

1

expressed

No

BA_5409

30259882

macrolide efflux pump, putative

544

Virulence

Phase 1: October 2007

1YQT

24.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00002
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0079

47566400

-

surface layer protein, (pxo1-54)

404

Drug Target Homolog

Phase 1: October 2007

3PYW

14.4%

Bacillus anthracis

IDP00130
(show subtarget assignments)

1

in_crystallization_trials

No

NT01ST5659

16767805

yjjV

putative deoxyribonuclease YjjV

257

Virulence

Phase 1: October 2007

1ZZM

76.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00016
(show subtarget assignments)

1

crystallized

No

BA_4053

46576983

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

491

Drug Target Homolog

Phase 1: October 2007

2WTZ

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00008
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1445

30255378

cysG

uroporphyrin-III C-methyltransferase

258

Drug Target Homolog

Phase 1: October 2007

1PJQ

43.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00129
(show subtarget assignments)

0

work_stopped

No

NT01ST3985

16766479

mdaB

NADPH-specific quinone oxidoreductase

193

Virulence

Phase 1: October 2007

2AMJ

91.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00064
(show subtarget assignments)

1

cloned

No

BA_5200

30259683

transcriptional activator tipA, putative...

243

Virulence

Phase 1: October 2007

3QAO

56.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00032
(show subtarget assignments)

1

purified

No

BA_1221

30255171

bacteriocin O-metyltransferase, putative...

281

Virulence

Phase 1: October 2007

2WK1

36.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00004
(show subtarget assignments)

1

soluble

No

BA_0001

38257418

Chromosomal replication initiator protei...

446

Drug Target Homolog

Phase 1: October 2007

2Z4R

37.2%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP00128
(show subtarget assignments)

1

soluble

No

NT01ST3027

16765755

pdxK

mp65f07.r1 Soares_thymus_2NbMT Mus muscu...

288

Essential

Phase 1: October 2007

2DDM

65.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00589
(show subtarget assignments)

1

soluble

No

YPO0954

161486886

mltC

membrane-bound lytic murein transglycosy...

358

Drug Target Function

Phase 2: March 2008

2Y8P

19.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01129
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5296

30259774

ferritin

168

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

48.2%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00588
(show subtarget assignments)

1

purified

No

YPO2077

16122316

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

87.8%

Yersinia pestis

Cellular processes

Cell division

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01126
(show subtarget assignments)

1

cloned

No

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00587
(show subtarget assignments)

1

cloned

No

YPO1507

16121780

mglB

galactose-binding protein

335

Virulence Associated Factor

Phase 2: March 2008

1GCA

80.9%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01124
(show subtarget assignments)

1

purified

No

BA_4938

33301353

UDP-N-acetylmuramate--L-alanine ligase (...

436

Conserved Gene / Pathway

Phase 2: March 2008

1J6U

30.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01123
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4267

30258769

ptsI

phosphoenolpyruvate-protein phosphotrans...

570

Conserved Gene / Pathway

Phase 2: March 2008

2HRO

65.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00586
(show subtarget assignments)

1

purified

No

YPO3789

16123923

metR

lysR-family transcriptional regulatory p...

317

Virulence Associated Factor

Phase 2: March 2008

1AL3

23.7%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01122
(show subtarget assignments)

1

soluble

No

BA_4045

30258552

ftsZ

cell division protein FtsZ

386

Conserved Gene / Pathway

Phase 2: March 2008

2VAM

78.1%

Bacillus anthracis

Cellular processes

Cell division

IDP00585
(show subtarget assignments)

1

expressed

No

YPO0116

16120461

metL

bifunctional aspartate kinase II/homoser...

811

Virulence Associated Factor

Phase 2: March 2008

1EBF

15.5%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01120
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1194

30254907

oligopeptide ABC transporter, ATP-bindin...

347

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01119
(show subtarget assignments)

1

purified

No

BA_0344

30253882

ahpF

alkyl hydroperoxide reductase, F subunit...

508

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

55.7%

Bacillus anthracis

Cellular processes

Detoxification

IDP00584
(show subtarget assignments)

1

soluble

No

YPO0117

16120462

metF

5,10-methylenetetrahydrofolate reductase...

294

Virulence Associated Factor

Phase 2: March 2008

1ZP3

86.4%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01118
(show subtarget assignments)

1

crystallized

No

BA_4030

81837831

Bifunctional protein pyrR [Includes: Pyr...

180

Conserved Gene / Pathway

Phase 2: March 2008

1A3C

73.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00583
(show subtarget assignments)

1

expressed

No

YPO2752

16122956

mepA

penicillin-insensitive murein endopeptid...

275

Drug Target Function

Phase 2: March 2008

1TZP

67.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01117
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3754

33301235

LexA repressor

206

Conserved Gene / Pathway

Phase 2: March 2008

3K2Z

38.3%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP01116
(show subtarget assignments)

1

expressed

No

BA_1693

30255984

glycosyl transferase, group 2 family pro...

150

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01115
(show subtarget assignments)

1

in_pdb
3IG4

No

BA_1901

30256561

xaa-pro aminopeptidase, putative

427

Drug Target Function

Phase 2: March 2008

3IG4

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00582
(show subtarget assignments)

1

in_pdb
3GSE

Yes

YPO2528

16122747

menF

menaquinone-specific isochorismate synth...

455

Conserved Gene / Pathway

Phase 2: March 2008

3GSE

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01114
(show subtarget assignments)

1

soluble

No

BA_4901

38502945

Septation ring formation regulator ezrA

570

Conserved Gene / Pathway

Phase 2: March 2008

Bacillus anthracis

Cellular processes

Cell division

IDP00581
(show subtarget assignments)

1

in_pdb
3RDW

Yes

YPO3070

16123247

putative arsenate reductase

118

Virulence Associated Factor

Phase 2: March 2008

3RDW

100%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01112
(show subtarget assignments)

1

in_pdb
3G48

No

BA_2064

30256713

csaA

chaperone CsaA

109

Conserved Gene / Pathway

Phase 2: March 2008

3G48

99.1%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01111
(show subtarget assignments)

1

cloned

No

BA_1135

49035527

Major cold shock protein cspA

67

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

73.1%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP00580
(show subtarget assignments)

1

purified

No

YPO0059

16120412

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

403

Conserved Gene / Pathway

Phase 2: March 2008

1FC4

82.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01110
(show subtarget assignments)

1

in_pdb
3RYK

Yes

BA_1229

30255178

rfbC

dTDP-4-dehydrorhamnose 3,5-epimerase

181

Conserved Gene / Pathway

Phase 2: March 2008

3RYK

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00579
(show subtarget assignments)

1

cloned

No

YPO1122

16121422

tolR

colicin uptake protein TolR

142

Conserved Gene / Pathway

Phase 2: March 2008

2JWK

23.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01109
(show subtarget assignments)

1

soluble

No

GBAA_pXO1_0148

47566460

hypothetical protein GBAA_pXO1_0148

150

Virulence Associated Factor

Phase 2: March 2008

3PMD

100%

Bacillus anthracis

IDP01108
(show subtarget assignments)

1

in_pdb

No

BA_3860

30258377

copper-ion-binding protein

68

Conserved Gene / Pathway

Phase 2: March 2008

2L3M

100%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01107
(show subtarget assignments)

1

soluble

No

BA_2250

30256894

heat shock protein, Hsp20 family

153

Conserved Gene / Pathway

Phase 2: March 2008

3AAB

24.2%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP00578
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3553

16123697

elbB

isoprenoid biosynthesis protein with ami...

217

Drug Target Function

Phase 2: March 2008

1OY1

63.6%

Yersinia pestis

Unknown function

General

IDP01106
(show subtarget assignments)

1

soluble

No

BA_1846

30256116

msrA-1

peptide methionine sulfoxide reductase

178

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

36%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP00577
(show subtarget assignments)

1

in_pdb
3OYT

Yes

YPO2757

16122961

fabB

3-oxoacyl-(acyl carrier protein) synthas...

407

Virulence Associated Factor

Phase 2: March 2008

3OYT

100%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01105
(show subtarget assignments)

1

purified

No

BA_2788

67460529

ATP-dependent Clp protease proteolytic s...

193

Drug Target Function

Phase 2: March 2008

3TT7

67.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01104
(show subtarget assignments)

1

soluble

No

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01103
(show subtarget assignments)

1

cloned

No

BA_1387

47605671

D-alanine--poly(phosphoribitol) ligase s...

79

Drug Target Function

Phase 2: March 2008

1DV5

45.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00576
(show subtarget assignments)

1

cloned

No

YPO1398

16121678

cspB

cold shock-like protein

69

Virulence Associated Factor

Phase 2: March 2008

3I2Z

50.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP01102
(show subtarget assignments)

1

soluble

No

BA_5424

49040749

Cold shock-like protein cspC

65

Essential Gene

Phase 2: March 2008

1C9O

74.2%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01101
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0119

47566439

hypothetical protein GBAA_pXO1_0119

82

Virulence Associated Factor

Phase 2: March 2008

3SIK

52.4%

Bacillus anthracis

IDP00574
(show subtarget assignments)

1

cloned

No

YPO0531

16120860

leuC

isopropylmalate isomerase large subunit ...

476

Virulence Associated Factor

Phase 2: March 2008

1ACO

25%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP01100
(show subtarget assignments)

1

in_pdb
3K1S

No

BA_5442

30259910

celC-2

PTS system, cellobiose-specific IIA comp...

107

Conserved Gene / Pathway

Phase 2: March 2008

3K1S

99.1%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01091
(show subtarget assignments)

1

in_crystallization_trials

No

STM4578

16767819

serB

phosphoserine phosphatase

322

Conserved Gene / Pathway

Phase 2: March 2008

3N28

47.2%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP00575
(show subtarget assignments)

1

in_pdb
3V4Z

No

YPO0557

16120885

ddl

D-alanine--D-alanine ligase

306

Drug Target Function

Phase 2: March 2008

3V4Z

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01090
(show subtarget assignments)

0

work_stopped

No

STM4567

16767808

deoC

deoxyribose-phosphate aldolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1JCL

94.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP00573
(show subtarget assignments)

1

in_pdb
3GO9

No

YPO3991

16124118

putative insulinase family protease

499

Drug Target Function

Phase 2: March 2008

3GO9

98.6%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01089
(show subtarget assignments)

1

soluble

No

STM4533

16767777

tsr

methyl-accepting chemotaxis protein I

553

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

49.5%

Salmonella enterica

Cellular processes

Chemotaxis and motility

Targets