Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05053 (show subtarget assignments)	1	expressed	No	CD0242	126697813		hypothetical protein CD0242 [Clostridium...	214	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3D5N	18.7%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP00961 (show subtarget assignments)	1	expressed	No	STM1385	16764735	ttrB	tetrathionate reductase complex subunit ...	250	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	34.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP00508 (show subtarget assignments)	1	expressed	No	YPO1315	16121597		putative hydrolase	216	Conserved Gene / Pathway	Phase 2: March 2008	3FVV	35.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP05766 (show subtarget assignments)	1	expressed	No	S0723	30040469		putative helicase [Shigella flexneri 2a ...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2R6A	31.7%	Shigella flexneri	DNA metabolism: DNA replication, recombination, and repair

IDP01950 (show subtarget assignments)	1	expressed	No	STM1939	16765280		putative glucose-6-phosphate dehydrogena...	108	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Energy metabolism	Glycolysis/gluconeogenesis

IDP05052 (show subtarget assignments)	1	expressed	No	CD0239	126697810	fliC	flagellin subunit [Clostridium difficile...	290	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3K8W	34.8%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP00506 (show subtarget assignments)	1	expressed	No	YPO2491	16122712		putative hemolysin activator protein	562	Conserved Gene / Pathway	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02755 (show subtarget assignments)	1	expressed	No	FTT1365c	56708418	fbaB	fructose-1,6-bisphosphate aldolase [Fran...	354	Conserved; Drug target functions	Phase 3: June 2008	3GAK	46.6%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00504 (show subtarget assignments)	1	expressed	No	YPO1015	16121316		hypothetical protein YPO1015	202	Drug Target Function	Phase 2: March 2008			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05044 (show subtarget assignments)	1	expressed	No	BA_3338	30257881		putative S-layer protein [Bacillus anthr...	360	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	15.6%	Bacillus anthracis	Cell envelope: Surface structures

IDP05755 (show subtarget assignments)	1	expressed	No	lmo0732	16802774	-	peptidoglycan binding protein [Listeria ...	638	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3RGX	17.6%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP01935 (show subtarget assignments)	1	expressed	No	CBU_0136	29540756	murC	UDP-N-acetylmuramate--alanine ligase [Co...	465	Conserved; Drug target functions	Phase 3: June 2008	2F00	47.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04426 (show subtarget assignments)	1	expressed	No	GBAA4339	47529636	bioF	8-amino-7-oxononanoate synthase [Bacillu...	395	putative drug target function;	Phase 4: April 2009	3A2B	33.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP05046 (show subtarget assignments)	1	expressed	No	BA_3529	30258064		hypothetical protein BA_3529 [Bacillus a...	117	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01930 (show subtarget assignments)	1	expressed	No	STM1578	16764922	narY	nitrate reductase 2 beta subunit [Salmon...	514	Conserved; Essential; Drug target functions	Phase 3: June 2008	1Q16	79%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01927 (show subtarget assignments)	1	expressed	No	CBU_1787	29542344	glmS	glucosamine--fructose-6-phosphate aminot...	611	Conserved; Drug target functions	Phase 3: June 2008	1JXA	58.3%	Coxiella burnetii	Central intermediary metabolism	Amino sugars

IDP00948 (show subtarget assignments)	1	expressed	No	STM1060	16764419		putative iron-sulfur protein	369	Conserved Gene / Pathway	Phase 2: March 2008	1ROE	8.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP00214 (show subtarget assignments)	1	expressed	No	YPO2252	16122476	-	putative toxin transport protein	712	Virulence	Phase 1: October 2007	2YL4	26.1%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP02764 (show subtarget assignments)	1	expressed	No	CBU_0525	29541128	serC	phosphoserine aminotransferase [Coxiella...	360	Conserved; Drug target functions	Phase 3: June 2008	3QBO	53.6%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01922 (show subtarget assignments)	1	expressed	No	GBAA1441	47526716	sat	sulfate adenylyltransferase [Bacillus an...	378	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1V47	39.4%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP00946 (show subtarget assignments)	1	expressed	No	STM0978	16764338	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	427	Conserved Gene / Pathway	Phase 2: March 2008	1G6S	89.5%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP01921 (show subtarget assignments)	1	expressed	No	CBU_1154	29541726	trpC	indole-3-glycerol phosphate synthase [Co...	257	Conserved; Drug target functions	Phase 3: June 2008	3QJA	37%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01920 (show subtarget assignments)	1	expressed	No	CBU_1156	29541728	trpA	tryptophan synthase, alpha subunit [Coxi...	267	Conserved; Drug target functions	Phase 3: June 2008	1V7Y	35.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02751 (show subtarget assignments)	1	expressed	No	FTT0634	56707759	hflC	SPFH domain-containing protein/band 7 fa...	308	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3BK6	13.6%	Francisella tularensis	Protein fateRegulatory functions	Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP05745 (show subtarget assignments)	1	expressed	No	CD2787	126700403	cwp84	cell surface protein (putative cell surf...	803	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1FH0	8.2%	Clostridium difficile	Cell envelope: Other

IDP02753 (show subtarget assignments)	1	expressed	No	GBAA4662	47529960	nadB	L-aspartate oxidase [Bacillus anthracis ...	509	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CHU	37.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00212 (show subtarget assignments)	1	expressed	No	YPO2123	16122358	-	putative phage minor tail protein	236	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP02748 (show subtarget assignments)	1	expressed	No	GBAA4408	47529702	accC	acetyl-CoA carboxylase biotin carboxylas...	450	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VPQ	66.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01910 (show subtarget assignments)	1	expressed	No	CBU_0798	29541392		multidrug resistance protein [Coxiella b...	331	Conserved; Drug target functions	Phase 3: June 2008	3FPP	19.3%	Coxiella burnetii	Transport and binding proteins	Other

IDP00939 (show subtarget assignments)	1	expressed	No	STM0828	16764190	glnQ	glutamine ABC transporter ATP-binding pr...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02742 (show subtarget assignments)	1	expressed	No	GBAA2122	47527416		hypothetical protein GBAA2122 [Bacillus ...	296	Conserved; Involved in sporulation;	Phase 3: June 2008	2R44	42.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP00497 (show subtarget assignments)	1	expressed	No	YPO1700	16121960		hypothetical protein YPO1700	184	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Other

IDP05737 (show subtarget assignments)	1	expressed	No	CD1990	126699598		hypothetical protein CD1990 [Clostridium...	139	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP01899 (show subtarget assignments)	1	expressed	No	STM2836	16766142	gutM	DNA-binding transcriptional activator Gu...	119	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Energy metabolism	Other

IDP01898 (show subtarget assignments)	1	expressed	No	STM1669	16765012		invasin-like protein [Salmonella typhimu...	660	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP01897 (show subtarget assignments)	1	expressed	No	STM3038	16766339		putative metalloendopeptidase [Salmonell...	252	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2GU1	18.3%	Salmonella enterica	Cell envelope	Other

IDP00495 (show subtarget assignments)	1	expressed	No	YPO1698	16121958		hypothetical protein YPO1698	185	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Other

IDP00931 (show subtarget assignments)	1	expressed	No	STM0615	16763992	ybdR	putative dehydrogenase	412	Essential Gene	Phase 2: March 2008	1KOL	32.5%	Salmonella enterica	Central intermediary metabolism	Other

IDP01893 (show subtarget assignments)	1	expressed	No	PSLT017	17233482	pefC	usher protein [Salmonella typhimurium LT...	802	Conserved; Drug target functions	Phase 3: June 2008	3RFZ	27.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02754 (show subtarget assignments)	1	expressed	No	Cj0527c	15791888	flgC	flagellar basal body rod protein FlgC [C...	164	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP00930 (show subtarget assignments)	1	expressed	No	STM0612	16763989		putative hydrogenase protein	185	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	30.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02737 (show subtarget assignments)	1	expressed	No	GBAA1974	47527269		putative lipoprotein [Bacillus anthracis...	415	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Other

IDP00493 (show subtarget assignments)	1	expressed	No	YPO1124	16121424	tolB	translocation protein TolB	430	Conserved Gene / Pathway	Phase 2: March 2008	1C5K	84.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP04401 (show subtarget assignments)	1	expressed	No	VC1831	15641833		sensor histidine kinase [Vibrio cholerae...	736	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.2%	Vibrio cholerae	Regulatory functions	Other

IDP01887 (show subtarget assignments)	1	expressed	No	GBAA5729	47531065	spo0J	stage 0 sporulation protein J [Bacillus ...	256	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	36.3%	Bacillus anthracis	Cellular processes	Sporulation and germination

IDP05720 (show subtarget assignments)	1	expressed	No	BA_2461	30257091		hypothetical protein BA_2461 [Bacillus a...	48	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05721 (show subtarget assignments)	1	expressed	No	BA_2686	30257298		hypothetical protein BA_2686 [Bacillus a...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05723 (show subtarget assignments)	1	expressed	No	BA_3001	30257589		alkaline phosphatase [Bacillus anthracis...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A52	25.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP01883 (show subtarget assignments)	1	expressed	No	STM0116	16763506	ilvI	acetolactate synthase 3 catalytic subuni...	553	Conserved; Drug target functions	Phase 3: June 2008	1JSC	43.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP00208 (show subtarget assignments)	1	expressed	No	YPO1979	16122221	-	putative dehydrogenase	338	Virulence	Phase 1: October 2007	2PK3	21.3%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02731 (show subtarget assignments)	1	expressed	No	CBU_0124	29540744	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	446	Conserved; Drug target functions	Phase 3: June 2008	1GG4	43.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05718 (show subtarget assignments)	1	expressed	No	BA_1601	30255901		putative lipoprotein [Bacillus anthracis...	103	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP01875 (show subtarget assignments)	1	expressed	No	GBAA0069	47525323	pabA-1	para-aminobenzoate/anthranilate synthase...	195	Conserved; Essential; Drug target functions	Phase 3: June 2008	1QDL	45.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04397 (show subtarget assignments)	1	expressed	No	GBAA3230	47528520		sensor histidine kinase [Bacillus anthra...	457	putative drug target function;	Phase 4: April 2009	2C2A	17.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP00488 (show subtarget assignments)	1	expressed	No	YPO1496	16121769		putative heme-binding protein	436	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Central intermediary metabolism	Sulfur metabolism

IDP00486 (show subtarget assignments)	1	expressed	No	YPO1463	16121738		putative acyl transferase	282	Conserved Gene / Pathway	Phase 2: March 2008	3RGI	47.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02484 (show subtarget assignments)	1	expressed	No	GBAA3922	47529214		zinc protease [Bacillus anthracis str. '...	428	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HDI	24.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05023 (show subtarget assignments)	1	expressed	No	BAS2353	49185362	-	hemolysin II, C-terminal [Bacillus anthr...	240	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3ANZ	27.9%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP05707 (show subtarget assignments)	1	expressed	No	lmo2762	16804799	-	hypothetical protein lmo2762 [Listeria m...	100	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H9C	44%	Listeria monocytogenes	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01856 (show subtarget assignments)	1	expressed	No	Cj1152c	15792476		putative phosphatase [Campylobacter jeju...	186	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2GMW	37.1%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00911 (show subtarget assignments)	1	expressed	No	STM0191	16763581	fhuA	ferrichrome outer membrane transporter	729	Conserved Gene / Pathway	Phase 2: March 2008	2FCP	72.3%	Salmonella enterica	Cell envelope	Other

IDP01854 (show subtarget assignments)	1	expressed	No	STM1246	16764600	pagC	virulence membrane protein PAGC precurso...	185	Conserved; Drug target functions	Phase 3: June 2008	1ORM	34.1%	Salmonella enterica	Cellular processes	Pathogenesis

IDP05702 (show subtarget assignments)	1	expressed	No	lmo2568	16804606	-	hypothetical protein lmo2568 [Listeria m...	107	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP00483 (show subtarget assignments)	1	expressed	No	YPO1316	16121598		putative iron/ascorbate oxidoreductase f...	355	Virulence Associated Factor	Phase 2: March 2008	3OOX	25.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP05019 (show subtarget assignments)	1	expressed	No	CD0267	126697839		hypothetical protein CD0267 [Clostridium...	145	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP02482 (show subtarget assignments)	1	expressed	No	CBU_1857	29542411	oppD	peptide ABC transporter, ATP-binding pro...	530	Conserved; Drug target functions	Phase 3: June 2008	3PIH	24.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP00908 (show subtarget assignments)	1	expressed	No	STM0143	16763533	hofB	hypothetical protein STM0143	461	Conserved Gene / Pathway	Phase 2: March 2008	1P9R	37.3%	Salmonella enterica	Cell envelope	Surface structures

IDP00204 (show subtarget assignments)	1	expressed	No	YPO1702	16121962	-	putative membrane protein	450	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00481 (show subtarget assignments)	1	expressed	No	YPO3558	16123702	gltD	glutamate synthase subunit beta	472	Virulence Associated Factor	Phase 2: March 2008	2VDC	43.2%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP05013 (show subtarget assignments)	1	expressed	No	CD0238	126697809		hypothetical protein CD0238 [Clostridium...	111	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05038 (show subtarget assignments)	1	expressed	No	BA_1902	30256562		multicopper oxidase family protein [Baci...	551	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3T6V	25.8%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP00902 (show subtarget assignments)	1	expressed	No	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01832 (show subtarget assignments)	1	expressed	No	GBAA5547	47530867	atpD	F0F1 ATP synthase subunit beta [Bacillus...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	86.4%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02740 (show subtarget assignments)	1	expressed	No	GBAA1950	47527245		D-alanyl-D-alanine carboxypeptidase fami...	285	Drug target motif; Drug target functions	Phase 3: June 2008	3HUM	28.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01827 (show subtarget assignments)	1	expressed	No	Cj0526c	15791887	fliE	flagellar hook-basal body protein FliE [...	98	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP04387 (show subtarget assignments)	1	expressed	No	YPO3606	218930616		putative Rhs accessory genetic element [...	800	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	14.4%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00897 (show subtarget assignments)	1	expressed	No	STM0771	16764135		putative ABC-type cobalamin/Fe3+-siderop...	258	Conserved Gene / Pathway	Phase 2: March 2008	2ONK	32.2%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00201 (show subtarget assignments)	1	expressed	No	YPO1476	16121751	-	hypothetical protein	727	Virulence	Phase 1: October 2007			Yersinia pestis	Energy metabolism	Photosynthesis

IDP00894 (show subtarget assignments)	1	expressed	No	STM4390	16767636		putative cytoplasmic protein	68	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01814 (show subtarget assignments)	1	expressed	No	STM1753	16765097	hnr	response regulator of RpoS [Salmonella t...	337	Conserved; Drug target functions	Phase 3: June 2008	3EOD	35.3%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00200 (show subtarget assignments)	1	expressed	No	YPO1473	16121748	-	hypothetical protein	766	Virulence	Phase 1: October 2007			Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01811 (show subtarget assignments)	1	expressed	No	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP00890 (show subtarget assignments)	1	expressed	No	STM3720	16767005	yibR	putative inner membrane protein	77	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Cell envelope	Other

IDP04382 (show subtarget assignments)	1	expressed	No	CPF_0116	110801065		sensor histidine kinase [Clostridium per...	337	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17.8%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP00472 (show subtarget assignments)	1	expressed	No	YPO0598	16120927		putative hemolysin activator protein	562	Virulence Associated Factor	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00887 (show subtarget assignments)	1	expressed	No	STM2349	16765676	yfcG	putative glutathione S-transferase	215	Conserved Gene / Pathway	Phase 2: March 2008	3GX0	80.5%	Salmonella enterica	Cellular processes	Detoxification

IDP00003 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0158	47566470	gerXC	spore germination protein xc, (pxo1-112)...	317	Drug Target Homolog	Phase 1: October 2007			Bacillus anthracis

IDP00470 (show subtarget assignments)	1	expressed	No	YPO0367	16120702		putative iron-sulfur cluster-binding pro...	411	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Energy metabolism	Electron transport

IDP04385 (show subtarget assignments)	1	expressed	No	YPO2689	115348373	kdpD	two-component regulatory protein sensor ...	908	conserved gene; putative drug target function;	Phase 4: April 2009	2R8R	14.3%	Yersinia pestis	Regulatory functions	Other

IDP00883 (show subtarget assignments)	1	expressed	No	STM1755	16765099	ychJ	hypothetical protein STM1755	152	Conserved Gene / Pathway	Phase 2: March 2008	2JQ5	30.9%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01795 (show subtarget assignments)	1	expressed	No	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01792 (show subtarget assignments)	1	expressed	No	GBAA0866	47777865	alsS	acetolactate synthase [Bacillus anthraci...	562	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1OZF	50.7%	Bacillus anthracis	Energy metabolism	Fermentation

IDP04460 (show subtarget assignments)	1	expressed	No	YPO1482	115347233		putative membrane protein [Yersinia pest...	1140	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP00097 (show subtarget assignments)	1	expressed	No	NTL02SF1117	30040935	S1242	hypothetical protein S1242	773	Virulence	Phase 1: October 2007	3QQ2	9.8%	Shigella flexneri	Cellular processes	Pathogenesis

IDP05667 (show subtarget assignments)	1	expressed	No	lmo0462	16802506	-	hypothetical protein lmo0462 [Listeria m...	161	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP01786 (show subtarget assignments)	1	expressed	No	CBU_0502	29541107		hydrolase, putative [Coxiella burnetii R...	225	Conserved; Drug target functions	Phase 3: June 2008	2GZX	44.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP01785 (show subtarget assignments)	1	expressed	No	CBU_0667	29541271	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxy...	271	Conserved; Drug target functions	Phase 3: June 2008	1KGQ	62.7%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01784 (show subtarget assignments)	1	expressed	No	STM1383	16764733	ttrA	tetrathionate reductase complex subunit ...	1020	Conserved; Drug target functions	Phase 3: June 2008	2IVF	18.1%	Salmonella enterica	Energy metabolism	Electron transport

IDP05053
(show subtarget assignments)

1

expressed

No

CD0242

126697813

hypothetical protein CD0242 [Clostridium...

214

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3D5N

18.7%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP00961
(show subtarget assignments)

1

expressed

No

STM1385

16764735

ttrB

tetrathionate reductase complex subunit ...

250

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

34.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP00508
(show subtarget assignments)

1

expressed

No

YPO1315

16121597

putative hydrolase

216

Conserved Gene / Pathway

Phase 2: March 2008

3FVV

35.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP05766
(show subtarget assignments)

1

expressed

No

S0723

30040469

putative helicase [Shigella flexneri 2a ...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2R6A

31.7%

Shigella flexneri

DNA metabolism: DNA replication, recombination, and repair

IDP01950
(show subtarget assignments)

1

expressed

No

STM1939

16765280

putative glucose-6-phosphate dehydrogena...

108

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Energy metabolism

Glycolysis/gluconeogenesis

IDP05052
(show subtarget assignments)

1

expressed

No

CD0239

126697810

fliC

flagellin subunit [Clostridium difficile...

290

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3K8W

34.8%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP00506
(show subtarget assignments)

1

expressed

No

YPO2491

16122712

putative hemolysin activator protein

562

Conserved Gene / Pathway

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02755
(show subtarget assignments)

1

expressed

No

FTT1365c

56708418

fbaB

fructose-1,6-bisphosphate aldolase [Fran...

354

Conserved; Drug target functions

Phase 3: June 2008

3GAK

46.6%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00504
(show subtarget assignments)

1

expressed

No

YPO1015

16121316

hypothetical protein YPO1015

202

Drug Target Function

Phase 2: March 2008

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05044
(show subtarget assignments)

1

expressed

No

BA_3338

30257881

putative S-layer protein [Bacillus anthr...

360

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

15.6%

Bacillus anthracis

Cell envelope: Surface structures

IDP05755
(show subtarget assignments)

1

expressed

No

lmo0732

16802774

-

peptidoglycan binding protein [Listeria ...

638

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3RGX

17.6%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP01935
(show subtarget assignments)

1

expressed

No

CBU_0136

29540756

murC

UDP-N-acetylmuramate--alanine ligase [Co...

465

Conserved; Drug target functions

Phase 3: June 2008

2F00

47.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04426
(show subtarget assignments)

1

expressed

No

GBAA4339

47529636

bioF

8-amino-7-oxononanoate synthase [Bacillu...

395

putative drug target function;

Phase 4: April 2009

3A2B

33.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP05046
(show subtarget assignments)

1

expressed

No

BA_3529

30258064

hypothetical protein BA_3529 [Bacillus a...

117

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01930
(show subtarget assignments)

1

expressed

No

STM1578

16764922

narY

nitrate reductase 2 beta subunit [Salmon...

514

Conserved; Essential; Drug target functions

Phase 3: June 2008

1Q16

79%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01927
(show subtarget assignments)

1

expressed

No

CBU_1787

29542344

glmS

glucosamine--fructose-6-phosphate aminot...

611

Conserved; Drug target functions

Phase 3: June 2008

1JXA

58.3%

Coxiella burnetii

Central intermediary metabolism

Amino sugars

IDP00948
(show subtarget assignments)

1

expressed

No

STM1060

16764419

putative iron-sulfur protein

369

Conserved Gene / Pathway

Phase 2: March 2008

1ROE

8.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP00214
(show subtarget assignments)

1

expressed

No

YPO2252

16122476

-

putative toxin transport protein

712

Virulence

Phase 1: October 2007

2YL4

26.1%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP02764
(show subtarget assignments)

1

expressed

No

CBU_0525

29541128

serC

phosphoserine aminotransferase [Coxiella...

360

Conserved; Drug target functions

Phase 3: June 2008

3QBO

53.6%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01922
(show subtarget assignments)

1

expressed

No

GBAA1441

47526716

sat

sulfate adenylyltransferase [Bacillus an...

378

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1V47

39.4%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP00946
(show subtarget assignments)

1

expressed

No

STM0978

16764338

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

427

Conserved Gene / Pathway

Phase 2: March 2008

1G6S

89.5%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP01921
(show subtarget assignments)

1

expressed

No

CBU_1154

29541726

trpC

indole-3-glycerol phosphate synthase [Co...

257

Conserved; Drug target functions

Phase 3: June 2008

3QJA

37%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01920
(show subtarget assignments)

1

expressed

No

CBU_1156

29541728

trpA

tryptophan synthase, alpha subunit [Coxi...

267

Conserved; Drug target functions

Phase 3: June 2008

1V7Y

35.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02751
(show subtarget assignments)

1

expressed

No

FTT0634

56707759

hflC

SPFH domain-containing protein/band 7 fa...

308

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3BK6

13.6%

Francisella tularensis

Protein fateRegulatory functions

Degradation of proteins, peptides, and glycopeptidesProtein interactions

IDP05745
(show subtarget assignments)

1

expressed

No

CD2787

126700403

cwp84

cell surface protein (putative cell surf...

803

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1FH0

8.2%

Clostridium difficile

Cell envelope: Other

IDP02753
(show subtarget assignments)

1

expressed

No

GBAA4662

47529960

nadB

L-aspartate oxidase [Bacillus anthracis ...

509

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CHU

37.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00212
(show subtarget assignments)

1

expressed

No

YPO2123

16122358

-

putative phage minor tail protein

236

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP02748
(show subtarget assignments)

1

expressed

No

GBAA4408

47529702

accC

acetyl-CoA carboxylase biotin carboxylas...

450

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VPQ

66.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01910
(show subtarget assignments)

1

expressed

No

CBU_0798

29541392

multidrug resistance protein [Coxiella b...

331

Conserved; Drug target functions

Phase 3: June 2008

3FPP

19.3%

Coxiella burnetii

Transport and binding proteins

Other

IDP00939
(show subtarget assignments)

1

expressed

No

STM0828

16764190

glnQ

glutamine ABC transporter ATP-binding pr...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02742
(show subtarget assignments)

1

expressed

No

GBAA2122

47527416

hypothetical protein GBAA2122 [Bacillus ...

296

Conserved; Involved in sporulation;

Phase 3: June 2008

2R44

42.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP00497
(show subtarget assignments)

1

expressed

No

YPO1700

16121960

hypothetical protein YPO1700

184

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Other

IDP05737
(show subtarget assignments)

1

expressed

No

CD1990

126699598

hypothetical protein CD1990 [Clostridium...

139

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP01899
(show subtarget assignments)

1

expressed

No

STM2836

16766142

gutM

DNA-binding transcriptional activator Gu...

119

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Energy metabolism

Other

IDP01898
(show subtarget assignments)

1

expressed

No

STM1669

16765012

invasin-like protein [Salmonella typhimu...

660

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01897
(show subtarget assignments)

1

expressed

No

STM3038

16766339

putative metalloendopeptidase [Salmonell...

252

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2GU1

18.3%

Salmonella enterica

Cell envelope

Other

IDP00495
(show subtarget assignments)

1

expressed

No

YPO1698

16121958

hypothetical protein YPO1698

185

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Other

IDP00931
(show subtarget assignments)

1

expressed

No

STM0615

16763992

ybdR

putative dehydrogenase

412

Essential Gene

Phase 2: March 2008

1KOL

32.5%

Salmonella enterica

Central intermediary metabolism

Other

IDP01893
(show subtarget assignments)

1

expressed

No

PSLT017

17233482

pefC

usher protein [Salmonella typhimurium LT...

802

Conserved; Drug target functions

Phase 3: June 2008

3RFZ

27.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02754
(show subtarget assignments)

1

expressed

No

Cj0527c

15791888

flgC

flagellar basal body rod protein FlgC [C...

164

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP00930
(show subtarget assignments)

1

expressed

No

STM0612

16763989

putative hydrogenase protein

185

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

30.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02737
(show subtarget assignments)

1

expressed

No

GBAA1974

47527269

putative lipoprotein [Bacillus anthracis...

415

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Other

IDP00493
(show subtarget assignments)

1

expressed

No

YPO1124

16121424

tolB

translocation protein TolB

430

Conserved Gene / Pathway

Phase 2: March 2008

1C5K

84.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP04401
(show subtarget assignments)

1

expressed

No

VC1831

15641833

sensor histidine kinase [Vibrio cholerae...

736

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.2%

Vibrio cholerae

Regulatory functions

Other

IDP01887
(show subtarget assignments)

1

expressed

No

GBAA5729

47531065

spo0J

stage 0 sporulation protein J [Bacillus ...

256

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

36.3%

Bacillus anthracis

Cellular processes

Sporulation and germination

IDP05720
(show subtarget assignments)

1

expressed

No

BA_2461

30257091

hypothetical protein BA_2461 [Bacillus a...

48

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05721
(show subtarget assignments)

1

expressed

No

BA_2686

30257298

hypothetical protein BA_2686 [Bacillus a...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05723
(show subtarget assignments)

1

expressed

No

BA_3001

30257589

alkaline phosphatase [Bacillus anthracis...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A52

25.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP01883
(show subtarget assignments)

1

expressed

No

STM0116

16763506

ilvI

acetolactate synthase 3 catalytic subuni...

553

Conserved; Drug target functions

Phase 3: June 2008

1JSC

43.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP00208
(show subtarget assignments)

1

expressed

No

YPO1979

16122221

-

putative dehydrogenase

338

Virulence

Phase 1: October 2007

2PK3

21.3%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02731
(show subtarget assignments)

1

expressed

No

CBU_0124

29540744

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

446

Conserved; Drug target functions

Phase 3: June 2008

1GG4

43.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05718
(show subtarget assignments)

1

expressed

No

BA_1601

30255901

putative lipoprotein [Bacillus anthracis...

103

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP01875
(show subtarget assignments)

1

expressed

No

GBAA0069

47525323

pabA-1

para-aminobenzoate/anthranilate synthase...

195

Conserved; Essential; Drug target functions

Phase 3: June 2008

1QDL

45.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04397
(show subtarget assignments)

1

expressed

No

GBAA3230

47528520

sensor histidine kinase [Bacillus anthra...

457

putative drug target function;

Phase 4: April 2009

2C2A

17.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP00488
(show subtarget assignments)

1

expressed

No

YPO1496

16121769

putative heme-binding protein

436

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Central intermediary metabolism

Sulfur metabolism

IDP00486
(show subtarget assignments)

1

expressed

No

YPO1463

16121738

putative acyl transferase

282

Conserved Gene / Pathway

Phase 2: March 2008

3RGI

47.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02484
(show subtarget assignments)

1

expressed

No

GBAA3922

47529214

zinc protease [Bacillus anthracis str. '...

428

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HDI

24.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05023
(show subtarget assignments)

1

expressed

No

BAS2353

49185362

-

hemolysin II, C-terminal [Bacillus anthr...

240

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3ANZ

27.9%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP05707
(show subtarget assignments)

1

expressed

No

lmo2762

16804799

-

hypothetical protein lmo2762 [Listeria m...

100

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H9C

44%

Listeria monocytogenes

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01856
(show subtarget assignments)

1

expressed

No

Cj1152c

15792476

putative phosphatase [Campylobacter jeju...

186

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2GMW

37.1%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00911
(show subtarget assignments)

1

expressed

No

STM0191

16763581

fhuA

ferrichrome outer membrane transporter

729

Conserved Gene / Pathway

Phase 2: March 2008

2FCP

72.3%

Salmonella enterica

Cell envelope

Other

IDP01854
(show subtarget assignments)

1

expressed

No

STM1246

16764600

pagC

virulence membrane protein PAGC precurso...

185

Conserved; Drug target functions

Phase 3: June 2008

1ORM

34.1%

Salmonella enterica

Cellular processes

Pathogenesis

IDP05702
(show subtarget assignments)

1

expressed

No

lmo2568

16804606

-

hypothetical protein lmo2568 [Listeria m...

107

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP00483
(show subtarget assignments)

1

expressed

No

YPO1316

16121598

putative iron/ascorbate oxidoreductase f...

355

Virulence Associated Factor

Phase 2: March 2008

3OOX

25.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP05019
(show subtarget assignments)

1

expressed

No

CD0267

126697839

hypothetical protein CD0267 [Clostridium...

145

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP02482
(show subtarget assignments)

1

expressed

No

CBU_1857

29542411

oppD

peptide ABC transporter, ATP-binding pro...

530

Conserved; Drug target functions

Phase 3: June 2008

3PIH

24.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP00908
(show subtarget assignments)

1

expressed

No

STM0143

16763533

hofB

hypothetical protein STM0143

461

Conserved Gene / Pathway

Phase 2: March 2008

1P9R

37.3%

Salmonella enterica

Cell envelope

Surface structures

IDP00204
(show subtarget assignments)

1

expressed

No

YPO1702

16121962

-

putative membrane protein

450

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00481
(show subtarget assignments)

1

expressed

No

YPO3558

16123702

gltD

glutamate synthase subunit beta

472

Virulence Associated Factor

Phase 2: March 2008

2VDC

43.2%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP05013
(show subtarget assignments)

1

expressed

No

CD0238

126697809

hypothetical protein CD0238 [Clostridium...

111

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05038
(show subtarget assignments)

1

expressed

No

BA_1902

30256562

multicopper oxidase family protein [Baci...

551

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3T6V

25.8%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP00902
(show subtarget assignments)

1

expressed

No

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01832
(show subtarget assignments)

1

expressed

No

GBAA5547

47530867

atpD

F0F1 ATP synthase subunit beta [Bacillus...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

86.4%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02740
(show subtarget assignments)

1

expressed

No

GBAA1950

47527245

D-alanyl-D-alanine carboxypeptidase fami...

285

Drug target motif; Drug target functions

Phase 3: June 2008

3HUM

28.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01827
(show subtarget assignments)

1

expressed

No

Cj0526c

15791887

fliE

flagellar hook-basal body protein FliE [...

98

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP04387
(show subtarget assignments)

1

expressed

No

YPO3606

218930616

putative Rhs accessory genetic element [...

800

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

14.4%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00897
(show subtarget assignments)

1

expressed

No

STM0771

16764135

putative ABC-type cobalamin/Fe3+-siderop...

258

Conserved Gene / Pathway

Phase 2: March 2008

2ONK

32.2%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00201
(show subtarget assignments)

1

expressed

No

YPO1476

16121751

-

hypothetical protein

727

Virulence

Phase 1: October 2007

Yersinia pestis

Energy metabolism

Photosynthesis

IDP00894
(show subtarget assignments)

1

expressed

No

STM4390

16767636

putative cytoplasmic protein

68

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01814
(show subtarget assignments)

1

expressed

No

STM1753

16765097

hnr

response regulator of RpoS [Salmonella t...

337

Conserved; Drug target functions

Phase 3: June 2008

3EOD

35.3%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00200
(show subtarget assignments)

1

expressed

No

YPO1473

16121748

-

hypothetical protein

766

Virulence

Phase 1: October 2007

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01811
(show subtarget assignments)

1

expressed

No

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP00890
(show subtarget assignments)

1

expressed

No

STM3720

16767005

yibR

putative inner membrane protein

77

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Cell envelope

Other

IDP04382
(show subtarget assignments)

1

expressed

No

CPF_0116

110801065

sensor histidine kinase [Clostridium per...

337

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17.8%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP00472
(show subtarget assignments)

1

expressed

No

YPO0598

16120927

putative hemolysin activator protein

562

Virulence Associated Factor

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00887
(show subtarget assignments)

1

expressed

No

STM2349

16765676

yfcG

putative glutathione S-transferase

215

Conserved Gene / Pathway

Phase 2: March 2008

3GX0

80.5%

Salmonella enterica

Cellular processes

Detoxification

IDP00003
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0158

47566470

gerXC

spore germination protein xc, (pxo1-112)...

317

Drug Target Homolog

Phase 1: October 2007

Bacillus anthracis

IDP00470
(show subtarget assignments)

1

expressed

No

YPO0367

16120702

putative iron-sulfur cluster-binding pro...

411

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Energy metabolism

Electron transport

IDP04385
(show subtarget assignments)

1

expressed

No

YPO2689

115348373

kdpD

two-component regulatory protein sensor ...

908

conserved gene; putative drug target function;

Phase 4: April 2009

2R8R

14.3%

Yersinia pestis

Regulatory functions

Other

IDP00883
(show subtarget assignments)

1

expressed

No

STM1755

16765099

ychJ

hypothetical protein STM1755

152

Conserved Gene / Pathway

Phase 2: March 2008

2JQ5

30.9%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01795
(show subtarget assignments)

1

expressed

No

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01792
(show subtarget assignments)

1

expressed

No

GBAA0866

47777865

alsS

acetolactate synthase [Bacillus anthraci...

562

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1OZF

50.7%

Bacillus anthracis

Energy metabolism

Fermentation

IDP04460
(show subtarget assignments)

1

expressed

No

YPO1482

115347233

putative membrane protein [Yersinia pest...

1140

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP00097
(show subtarget assignments)

1

expressed

No

NTL02SF1117

30040935

S1242

hypothetical protein S1242

773

Virulence

Phase 1: October 2007

3QQ2

9.8%

Shigella flexneri

Cellular processes

Pathogenesis

IDP05667
(show subtarget assignments)

1

expressed

No

lmo0462

16802506

-

hypothetical protein lmo0462 [Listeria m...

161

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP01786
(show subtarget assignments)

1

expressed

No

CBU_0502

29541107

hydrolase, putative [Coxiella burnetii R...

225

Conserved; Drug target functions

Phase 3: June 2008

2GZX

44.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP01785
(show subtarget assignments)

1

expressed

No

CBU_0667

29541271

dapD

2,3,4,5-tetrahydropyridine-2,6-dicarboxy...

271

Conserved; Drug target functions

Phase 3: June 2008

1KGQ

62.7%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01784
(show subtarget assignments)

1

expressed

No

STM1383

16764733

ttrA

tetrathionate reductase complex subunit ...

1020

Conserved; Drug target functions

Phase 3: June 2008

2IVF

18.1%

Salmonella enterica

Energy metabolism

Electron transport