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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
In
IDP#
NCBI GI
LOCUS TAG
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Page 23 of 60, showing 100 records out of 5973 total, starting on record 2201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP02371
(
show subtarget assignments
)
1
expressed
No
CBU_1904
29542461
ftsE
cell division ABC transporter, ATP-bindi...
217
Conserved; Drug target functions
Phase 3: June 2008
1F3O
38.1%
Coxiella burnetii
Transport and binding proteins
Unknown substrate
IDP00305
(
show subtarget assignments
)
1
cloned
No
CBU_0118
29653476
pbpB
penicillin-binding protein 3
548
Drug Target Function
Phase 2: March 2008
3OC2
45.3%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02361
(
show subtarget assignments
)
1
expressed
No
CBU_1550
29542109
ptsP
phosphoenolpyruvate-protein phosphotrans...
759
Conserved; Drug target functions
Phase 3: June 2008
2HRO
28.3%
Coxiella burnetii
Signal transduction
PTS
IDP00304
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0038
29653401
3-oxoacyl-(acyl-carrier-protein) synthas...
327
Drug Target Function
Phase 2: March 2008
1UB7
29.6%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00303
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0035
29653398
beta-ketoacyl synthase
424
Drug Target Function
Phase 2: March 2008
3E60
36.8%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00302
(
show subtarget assignments
)
1
expressed
No
CBU_1155
29654460
trpBF
N-(5'phosphoribosyl)anthranilate isomera...
600
Drug Target Function
Phase 2: March 2008
1V8Z
38%
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP02543
(
show subtarget assignments
)
1
expressed
No
CBU_0275
29540889
hemE
uroporphyrinogen decarboxylase [Coxiella...
361
Conserved; Drug target functions
Phase 3: June 2008
3CYV
55.1%
Coxiella burnetii
Biosynthesis of cofactors, prosthetic groups, and carriers
Heme, porphyrin, and cobalamin
IDP00301
(
show subtarget assignments
)
1
expressed
No
CBU_0983
291
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
3NVT
10.7%
Coxiella burnetii
IDP00300
(
show subtarget assignments
)
1
cloned
No
CBU_1153
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
1GXB
10.4%
Coxiella burnetii
IDP02540
(
show subtarget assignments
)
1
cloned
No
CBU_1584
29542144
shaE
monovalent cation/proton antiporter subu...
115
Conserved; Drug target functions
Phase 3: June 2008
Coxiella burnetii
Transport and binding proteins
Cations and iron carrying compounds
IDP91587
(
show subtarget assignments
)
8
expressed
No
CBU_1108
29541682
hypothetical protein
219
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP02552
(
show subtarget assignments
)
1
expressed
No
CBU_0743
29541343
ptsH
phosphocarrier protein HPr [Coxiella bur...
89
Conserved; Drug target functions
Phase 3: June 2008
3LE1
46.1%
Coxiella burnetii
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP02541
(
show subtarget assignments
)
1
expressed
No
CBU_1709
29542267
dapB
dihydrodipicolinate reductase [Coxiella ...
239
Conserved; Drug target functions
Phase 3: June 2008
1YL5
42.3%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP02284
(
show subtarget assignments
)
1
soluble
No
CBU_1293
29541861
grpE
heat shock protein GrpE [Coxiella burnet...
204
Conserved; Drug target functions
Phase 3: June 2008
1DKG
35.3%
Coxiella burnetii
Protein fate
Protein folding and stabilization
IDP91667
(
show subtarget assignments
)
8
selected
No
POLG_CXB3W
0
2185
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2IJD
20.7%
Coxsackievirus B3
IDP00274
(
show subtarget assignments
)
1
selected
No
AF180817_2494-3392
7329982
N/A
NS5 methyl transferase and RNA polymeras...
830
RNA-dependent RNA polymerase
Phase 3: June 2008
2J7U
55.5%
Dengue virus
Transcription
N/A
IDP00273
(
show subtarget assignments
)
1
selected
No
AF180817_1476-2094
7329982
N/A
NS3 RNA Helicase
619
Polyprotein processing, RNA replication
Phase 3: June 2008
2WZQ
76.4%
Dengue virus
Transcription
N/A
IDP00272
(
show subtarget assignments
)
1
in_pdb
3EGP
3IRC
No
AF180817_281-775
7329982
N/A
Envelope (E)
495
Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...
Phase 1: October 2007
3G7T
78.8%
Dengue virus
N/A
IDP00271
(
show subtarget assignments
)
1
expressed
No
AF180817_115-280
7329982
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
59.6%
Dengue virus
N/A
IDP00270
(
show subtarget assignments
)
1
cloned
No
AF180817_2245-2493
7329982
N/A
NS4B
249
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00269
(
show subtarget assignments
)
1
cloned
No
AF180817_776-1127
7329982
N/A
NS1
352
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00263
(
show subtarget assignments
)
1
cloned
No
AF180817_1-114
7329982
N/A
Capsid protein (C)
114
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.5%
Dengue virus
Unclassified
N/A
IDP92564
(
show subtarget assignments
)
8
selected
No
3L6P_A
290560467
Chain A, Crystal Structure Of Dengue Vir...
236
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
3L6P
100%
Dengue virus
IDP00275
(
show subtarget assignments
)
1
cloned
No
NP_056776_776-1127
159024209
N/A
NS1
352
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00264
(
show subtarget assignments
)
1
expressed
No
NP_056776_2244-2491
159024209
N/A
NS4B
248
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP91056
(
show subtarget assignments
)
8
expressed
No
AAA42941
323448
viral polyprotein [Dengue virus 2]
3391
potential drug target /
A structure of the co-complex between Dengue 2 strain 16681 full length NS3 and ...
Community Requests
2J7U
15.1%
Dengue virus
IDP92565
(
show subtarget assignments
)
8
selected
No
AAA66406
807601
nonstructural protein 1, partial [Dengue...
886
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
2WZQ
38.7%
Dengue virus
IDP00276
(
show subtarget assignments
)
1
soluble
No
AAA99437_115-280
323469
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
56%
Dengue virus
N/A
IDP00265
(
show subtarget assignments
)
1
selected
No
AAA99437_775-1129
323469
N/A
NS1
355
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP92567
(
show subtarget assignments
)
8
selected
No
AEF33500
333454592
polyprotein, partial [Dengue virus 3]
749
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
2VBC
65.2%
Dengue virus
IDP00279
(
show subtarget assignments
)
1
selected
No
AAA99437_2243-2483
323469
N/A
NS4B
241
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00277
(
show subtarget assignments
)
1
cloned
No
AAA99437_5-114
323469
N/A
Capsid protein (C)
110
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
57.3%
Dengue virus
Unclassified
N/A
IDP00278
(
show subtarget assignments
)
1
selected
No
AAA99437_1474-2092
323469
N/A
NS3 RNA Helicase
619
Polyprotein processing, RNA replication
Phase 3: June 2008
2VBC
78.9%
Dengue virus
Transcription
N/A
IDP00268
(
show subtarget assignments
)
1
cloned
No
AAX48017_2488-3387
61652905
N/A
NS5 methyl transferase and RNA polymeras...
900
RNA-dependent RNA polymerase
Phase 3: June 2008
2J7U
54.7%
Dengue virus
Transcription
N/A
IDP00267
(
show subtarget assignments
)
1
cloned
No
AAX48017_4-113
61652905
N/A
Capsid protein (C)
111
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.4%
Dengue virus
Unclassified
N/A
IDP00266
(
show subtarget assignments
)
1
cloned
No
AAX48017_114-279
61652905
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
57.2%
Dengue virus
N/A
IDP00280
(
show subtarget assignments
)
1
purified
No
AAX48017_51-545
604449
N/A
Envelope (E)
495
Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...
Phase 3: June 2008
3UAJ
79.2%
Dengue virus
N/A
IDP92566
(
show subtarget assignments
)
8
selected
No
AAO83387
29725867
polyprotein, partial [Dengue virus 4]
263
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
2VBC
67.7%
Dengue virus
IDP00282
(
show subtarget assignments
)
1
cloned
No
AAX48017_2243-2483
61652905
N/A
NS4B
241
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00281
(
show subtarget assignments
)
1
cloned
No
AAX48017_776-1130
61652905
N/A
NS1
355
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP05773
(
show subtarget assignments
)
1
in_pdb
3OQ3
No
AAX23681
60547415
soluble interferon-alpha/beta receptor [...
358
essential/virulence/pathogenesis /
An ortholog of IDP90145 (EVM166), a monkeypox target. The description of the mou...
Phase 5: 2010
3OQ3
91.6%
Ectromelia virus
IDP91053
(
show subtarget assignments
)
8
in_crystallization_trials
No
ENC0002
0
247
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3B89
42.1%
Enterobacter cloacae
IDP91795
(
show subtarget assignments
)
8
purified
No
CAA24789
47034
unnamed protein product [Enterococcus fa...
264
other biological interest /
Kinase
Community Requests
1J7I
100%
Enterococcus faecalis
IDP91799
(
show subtarget assignments
)
8
selected
No
AAL27442
16612079
vanE
VanE [Enterococcus faecalis]
352
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1E4E
41.5%
Enterococcus faecalis
IDP91879
(
show subtarget assignments
)
8
selected
No
AAQ16273
33355853
vanG
D-Ala:D-Ser ligase [Enterococcus faecali...
349
drug resistance /
The proteins play important roles in vancomycin resistance of Entercocci.
Community Requests
3SE7
46.4%
Enterococcus faecalis
IDP92246
(
show subtarget assignments
)
8
selected
No
EF_2296
2499116
RecName: Full=Vancomycin B-type resistan...
275
drug resistance /
Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...
Community Requests
Enterococcus faecalis
IDP92247
(
show subtarget assignments
)
8
selected
No
ABA71730
77380198
vanWG
VanWG [Enterococcus faecalis]
281
drug resistance /
Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...
Community Requests
Enterococcus faecalis
IDP91871
(
show subtarget assignments
)
8
selected
No
AAB05624
1209528
vanYB
D,D-carboxypeptidase [Enterococcus faeca...
268
drug resistance /
confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...
Community Requests
Enterococcus faecalis
IDP91050
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFE0001
1209531
vanB
D-Ala:D-Lac ligase [Enterococcus faecali...
342
drug resistance /
D-lactate D-ala ligase; generates vancomycin resistant cell wall
Community Requests
1E4E
75.1%
Enterococcus faecalis
IDP91046
(
show subtarget assignments
)
8
in_pdb
4ECL
No
EFE0004
33355854
vanTG
serine racemase [Enterococcus faecalis]
712
drug resistance /
Putative serine racemase involved in synthesis of D-Ala-D-Ser, a component of va...
Community Requests
4ECL
52.5%
Enterococcus faecalis
IDP91773
(
show subtarget assignments
)
8
purified
No
AAB05628
1209532
vanXB
D,D-dipeptidase [Enterococcus faecalis]
202
drug resistance /
D,D-dipeptidase
Community Requests
1R44
74.8%
Enterococcus faecalis
IDP91041
(
show subtarget assignments
)
8
in_pdb
3TYS
3TYR
No
EFE0002
33355847
vanUG
predicted transcriptional regulator [Ent...
75
drug resistance /
Putative transcriptional regulator
Community Requests
3T75
89.3%
Enterococcus faecalis
IDP91043
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFE0003
33355848
vanRG
response regulator [Enterococcus faecali...
235
drug resistance /
Component of regulatory system of transcription of vancomycin resistance genes
Community Requests
1P2F
37%
Enterococcus faecalis
IDP91044
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFA0002
110556113
vanY
vanY [Enterococcus faecalis]
303
drug resistance /
A carboxypeptidase thought to be involved in breakdown of normal cell wall
Community Requests
Enterococcus faecalis
IDP91049
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFE0005
160947043
vanTrL
serine racemase [Enterococcus faecalis]
366
drug resistance /
Soluble component of serine racemase involved in synthesis of vancomycin resista...
Community Requests
4ECL
42.6%
Enterococcus faecalis
IDP91780
(
show subtarget assignments
)
8
cloned
No
CAA27977
48190
unnamed protein product [Enterococcus fa...
639
drug resistance /
Tetracycline resistance
Community Requests
1DAR
28.4%
Enterococcus faecalis
IDP91781
(
show subtarget assignments
)
8
purified
No
AAV80411
56155277
tetO
TetO [Enterococcus faecalis]
639
drug resistance /
Tetracycline resistance
Community Requests
1DAR
27.9%
Enterococcus faecalis
IDP91775
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAL27443
16612080
vanXYE
VanXYE [Enterococcus faecalis]
193
drug resistance /
D,D-dipeptidase/D,D-carboxypeptidase
Community Requests
Enterococcus faecalis
IDP91774
(
show subtarget assignments
)
8
in_pdb
4F78
No
AAQ16272
33355852
vanXYG
D,D-dipeptidase/D,D-carboxypeptidase [En...
254
drug resistance /
D,D-dipeptidase/D,D-carboxypeptidase
Community Requests
Enterococcus faecalis
IDP91190
(
show subtarget assignments
)
1
in_crystallization_trials
No
EF_A0061
29345308
6'-aminoglycoside N-acetyltransferase [E...
479
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R6Z
20%
Enterococcus faecalis
IDP91776
(
show subtarget assignments
)
8
in_crystallization_trials
No
ACM47288
222159815
vanXD
D,D-dipeptidase VanXD [Enterococcus faec...
202
drug resistance /
D,D-dipeptidase
Community Requests
1R44
70.3%
Enterococcus faecium
IDP91872
(
show subtarget assignments
)
8
selected
No
ACM47285
222159812
vanYD
D,D-carboxypeptidase VanYD [Enterococcus...
363
drug resistance /
confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...
Community Requests
1ES4
24%
Enterococcus faecium
IDP91878
(
show subtarget assignments
)
8
selected
No
pVEF1_014
121633839
vanB
VanA protein [Enterococcus faecium]
343
drug resistance /
The proteins play important roles in vancomycin resistance of Entercocci.
Community Requests
1E4E
98.8%
Enterococcus faecium
IDP91187
(
show subtarget assignments
)
1
in_pdb
3UZR
4DCA
Yes
AF207840_1
10130002
aph(2')-Ib
aminoglycoside phosphotransferase [Enter...
299
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3HAM
100%
Enterococcus faecium
IDP91189
(
show subtarget assignments
)
1
in_pdb
4DE4
4DFB
4DFU
Yes
AAW59417
57918602
aph(2'')-Id
APH(2'')-Id [Enterococcus faecium]
301
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3LZH
100%
Enterococcus faecium
IDP91047
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFA0003
5353563
vanRD
response regulator [Enterococcus faecium...
232
drug resistance /
Component of regulatory system of transcription of vancomycin resistance genes
Community Requests
2GWR
37.1%
Enterococcus faecium
IDP91791
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAA24789
148330
vanH
vancomycin resistance protein [Enterococ...
322
drug resistance /
Dehydrogenase that reduces pyruvate to D-lactate, which is required to produce a...
Community Requests
3KB6
35.7%
Enterococcus faecium
IDP91788
(
show subtarget assignments
)
8
in_crystallization_trials
No
ACM47287
222159814
vanD
D-Ala:D-Lac ligase VanD [Enterococcus fa...
343
drug resistance /
D-Ala:D-Lac ligase
Community Requests
1E4E
67.1%
Enterococcus faecium
IDP91547
(
show subtarget assignments
)
8
selected
No
EfaeDRAFT_0205
69249189
Protein of unknown function DUF470:Prote...
866
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Enterococcus faecium
IDP91548
(
show subtarget assignments
)
8
selected
No
EfaeDRAFT_1579
69245409
Protein of unknown function DUF472 [Ente...
857
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Enterococcus faecium
IDP91796
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAB49832
1854639
gentamicin resistance protein [Enterococ...
306
other biological interest /
Kinase
Community Requests
3TDV
100%
Enterococcus gallinarum
IDP91787
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAA24786
148325
vanC
D-alanine-D-alanine ligase-related prote...
343
drug resistance /
D-Ala:D-Ser ligase
Community Requests
1E4E
39%
Enterococcus gallinarum
IDP91778
(
show subtarget assignments
)
8
in_crystallization_trials
No
AF132548_1
7380949
vanXYc
D,D-dipeptidase/D,D-carboxypeptidase Van...
190
drug resistance /
Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) acti...
Community Requests
Enterococcus gallinarum
IDP91048
(
show subtarget assignments
)
8
in_crystallization_trials
No
EGA0001
4545123
vanT
serine racemase VanT [Enterococcus galli...
698
drug resistance /
Serine racemase involved in synthesis of D-Ala-D-Ser, a component of vancomycin ...
Community Requests
4ECL
22.3%
Enterococcus gallinarum
IDP91544
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAE54319
83627318
ereB
erythromycin esterase type II [Escherich...
419
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2QGM
25.8%
Escherichia coli
IDP92558
(
show subtarget assignments
)
8
selected
No
CAA87463
1065719
aadB
aminoglycoside adenylyltransferase [Esch...
177
drug resistance /
This enzyme is one of the most clinically widespread aminogylcoside-deactivating...
Community Requests
Escherichia coli
IDP91188
(
show subtarget assignments
)
1
crystallized
No
CAA24743
40923
unnamed protein product [Escherichia col...
341
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OVC
100%
Escherichia coli
IDP91877
(
show subtarget assignments
)
8
selected
No
CAB89086
7649401
fox-4
beta-lactamase class C [Escherichia coli...
382
potential drug target /
Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...
Community Requests
1ZKJ
71.7%
Escherichia coli
IDP91800
(
show subtarget assignments
)
8
in_crystallization_trials
No
p6418_01
219372022
sul2
dihydropteroate synthase [Escherichia co...
271
drug resistance /
Deactivates antibiotic sulfonamide by ligating on p-aminobenzoic acid; we will c...
Community Requests
2Y5J
38.1%
Escherichia coli
IDP91797
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAA23892
43749
neomycin phosphotransferase [Escherichia...
264
other biological interest /
Kinase
Community Requests
1ND4
100%
Escherichia coli
IDP91794
(
show subtarget assignments
)
8
crystallized
No
BAA12910
1695688
mphB
macrolide 2'-phosphotransferase II [Esch...
302
other biological interest /
Kinase
Community Requests
3TDW
18.5%
Escherichia coli
IDP91793
(
show subtarget assignments
)
8
in_crystallization_trials
No
BAA03776
807707
mphA
macrolide 2'-phosphotransferase I [Esche...
301
other biological interest /
Kinase
Community Requests
3TDV
21.3%
Escherichia coli
IDP91777
(
show subtarget assignments
)
8
purified
No
AAC33914
3513664
sul1
Sul1 dihydropteroate synthase [Escherich...
279
drug resistance /
Dihydropteroate synthase (sulfonamide resistance)
Community Requests
1EYE
35.1%
Escherichia coli
IDP91772
(
show subtarget assignments
)
8
expressed
No
AAR87481
40548828
sul3
dihydropteroate synthase [Escherichia co...
242
drug resistance /
Dihydropteroate synthase (sulfonamide resistance)
Community Requests
1TWS
36.4%
Escherichia coli
IDP91737
(
show subtarget assignments
)
8
selected
No
Q5WMC9_ECOLX
0
550
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1F02
11.1%
Escherichia coli
IDP90092
(
show subtarget assignments
)
8
purified
No
ZZZ_0008
155
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90098
(
show subtarget assignments
)
8
purified
No
ZZZ_0014
196
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
3U66
19.4%
Escherichia coli
IDP90099
(
show subtarget assignments
)
8
cloned
No
ZZZ_0015
1137
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90097
(
show subtarget assignments
)
8
cloned
No
ZZZ_0013
104
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90096
(
show subtarget assignments
)
8
expressed
No
ZZZ_0012
476
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90100
(
show subtarget assignments
)
8
expressed
No
ZZZ_0016
849
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
1QVR
36.8%
Escherichia coli
IDP90093
(
show subtarget assignments
)
8
expressed
No
ZZZ_0009
99
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90094
(
show subtarget assignments
)
8
cloned
No
ZZZ_0010
358
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90095
(
show subtarget assignments
)
8
soluble
No
ZZZ_0011
184
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90086
(
show subtarget assignments
)
8
expressed
No
ZZZ_0002
492
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90087
(
show subtarget assignments
)
8
cloned
No
ZZZ_0003
168
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90085
(
show subtarget assignments
)
8
purified
No
ZZZ_0001
158
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90088
(
show subtarget assignments
)
8
soluble
No
ZZZ_0004
140
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90089
(
show subtarget assignments
)
8
expressed
No
ZZZ_0005
600
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90090
(
show subtarget assignments
)
8
expressed
No
ZZZ_0006
310
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
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