Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91910 (show subtarget assignments)	8	selected	No	SpneCM_010100003565	298254678		surface protein PspC, partial [Streptoco...	187	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2GRX	25.7%	Streptococcus pneumoniae

IDP01324 (show subtarget assignments)	1	cloned	No	VCA0910	15601664		tonB1 protein	249	Conserved Gene / Pathway	Phase 2: March 2008	2GRX	27.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP91689 (show subtarget assignments)	8	selected	No	NP_000706	4502503	C4BPA	C4b-binding protein alpha chain precurso...	597	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2GSX	28.8%	Homo sapiens

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02806 (show subtarget assignments)	1	cloned	No	Cj1133	15792458	waaC	lipopolysaccharide heptosyltransferase I...	342	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2GT1	23.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90822 (show subtarget assignments)	8	purified	No	YPO0056	16120409	rfaC	ADP-heptose:LPS heptosyl transferase I [...	321	Predicted Essential	Community Requests	2GT1	67.9%	Yersinia pestis

IDP02235 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1105c	56708184	msrA1	bifunctional methionine sulfoxide reduct...	284	Drug Target	Phase 3: June 2008	2GT3	23.2%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP01106 (show subtarget assignments)	1	soluble	No	BA_1846	30256116	msrA-1	peptide methionine sulfoxide reductase	178	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	36%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP01467 (show subtarget assignments)	1	purified	No	VC2549	15642544		methionine sulfoxide reductase A	212	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	56.1%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP92127 (show subtarget assignments)	8	selected	No	TGME49_021310	237841325		aminopeptidase N, putative [Toxoplasma g...	966	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2GTQ	33.6%	Toxoplasma gondii

IDP02031 (show subtarget assignments)	1	cloned	No	lmo2504	16804542		hypothetical protein lmo2504 [Listeria m...	436	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2GU1	17.2%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01897 (show subtarget assignments)	1	expressed	No	STM3038	16766339		putative metalloendopeptidase [Salmonell...	252	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2GU1	18.3%	Salmonella enterica	Cell envelope	Other

IDP00209 (show subtarget assignments)	1	soluble	No	YPO2062	16122301	-	putative M23/M37 peptidase-family protei...	417	Virulence	Phase 1: October 2007	2GU1	32.4%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP02611 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0111	47566431		M23/37 family peptidase [Bacillus anthra...	523	Drug target motif; Vaccine Target	Phase 3: June 2008	2GU1	10.1%	Bacillus anthracis	N/A	N/A

IDP00057 (show subtarget assignments)	1	soluble	No	BA_3900	30258414		lantibiotic biosynthesis DNA-binding res...	220	Virulence	Phase 1: October 2007	2GWR	34.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91047 (show subtarget assignments)	8	in_crystallization_trials	No	EFA0003	5353563	vanRD	response regulator [Enterococcus faecium...	232	drug resistance / Component of regulatory system of transcription of vancomycin resistance genes	Community Requests	2GWR	37.1%	Enterococcus faecium

IDP91042 (show subtarget assignments)	8	in_crystallization_trials	No	ACB0002	38230268		AdeR [Acinetobacter baumannii]	247	Regulator protein of transcription of antibiotic drug-efflux pump AdeABC	Community Requests	2GWR	33.2%	Acinetobacter baumannii

IDP04599 (show subtarget assignments)	1	cloned	No	BAS2268	49185277		aspartate-semialdehyde dehydrogenase [Ba...	347	Proposed to be essential proteins	Phase 4: April 2009	2GYY	55.3%	Bacillus anthracis

IDP02467 (show subtarget assignments)	1	soluble	No	GBAA3937	47529228	asd-2	aspartate-semialdehyde dehydrogenase [Ba...	348	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GYY	60.6%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP00018 (show subtarget assignments)	0	work_stopped	No	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00309 (show subtarget assignments)	1	expressed	No	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01786 (show subtarget assignments)	1	expressed	No	CBU_0502	29541107		hydrolase, putative [Coxiella burnetii R...	225	Conserved; Drug target functions	Phase 3: June 2008	2GZX	44.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP04067 (show subtarget assignments)	1	purified	No	BAS4417	49187412		thioredoxin [Bacillus anthracis str. Ste...	104	Proposed to be essential proteins	Phase 4: April 2009	2GZY	75%	Bacillus anthracis

IDP02654 (show subtarget assignments)	1	cloned	No	Cj1682c	15792986	gltA	citrate synthase [Campylobacter jejuni s...	422	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	2H12	50.2%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP90738 (show subtarget assignments)	8	soluble	No	Cj0116	15791504	fabD	malonyl CoA-acyl carrier protein transac...	306	Predicted Essential	Community Requests	2H1Y	49.3%	Campylobacter jejuni

IDP91248 (show subtarget assignments)	8	soluble	No	HP0090	2313169		malonyl coenzyme A-acyl carrier protein ...	309	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2H1Y	98.1%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP02293 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1445	56708487	trxA1	thioredoxin [Francisella tularensis subs...	107	Conserved; Drug target functions	Phase 3: June 2008	2H71	50.5%	Francisella tularensis	Energy metabolism	Electron transport

IDP04639 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0556c	56707686	oxyR	oxidative stress transcriptional regulat...	289	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2H98	26.2%	Francisella tularensis	Regulatory functions	DNA interactions

IDP92556 (show subtarget assignments)	8	selected	No	VV1_1076	27360618		HTH-type transcriptional regulator ilvY ...	296	potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...	Community Requests	2H99	21.6%	Vibrio vulnificus

IDP00221 (show subtarget assignments)	1	soluble	No	YPO0164	16120507	-	putative membrane receptor protein	686	Virulence	Phase 1: October 2007	2HDF	20.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91021 (show subtarget assignments)	8	cloned	No	y2872	22126749	yiuR	putative outer membrane receptor [Yersin...	665	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	2HDF	38%	Yersinia pestis

IDP00153 (show subtarget assignments)	1	expressed	No	VC0475	15640502	irgA	enterobactin receptor	652	Virulence	Phase 1: October 2007	2HDF	37.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02385 (show subtarget assignments)	1	cloned	No	Cj0755	15792094	cfrA	putative iron uptake protein [Campylobac...	696	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	2HDF	29.8%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP90981 (show subtarget assignments)	8	selected	No	y0850	22124761		outer membrane receptor [Yersinia pestis...	731	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	2HDF	31.1%	Yersinia pestis

IDP01422 (show subtarget assignments)	1	expressed	No	VC1549	15641557		glycerol-3-phosphate ABC transporter, pe...	434	Conserved Gene / Pathway	Phase 2: March 2008	2HEU	20%	Vibrio cholerae	Transport and binding proteins	Other

IDP91638 (show subtarget assignments)	8	expressed	No	NP_216897	15609518		polyketide synthetase MBTD (polyketide s...	1004	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2HG4	15.5%	Mycobacterium tuberculosis

IDP91804 (show subtarget assignments)	8	selected	No	ZP_04523236	237510521		putative polyketide synthase PksL (PKS) ...	4567	virulence/pathogenesis / Emerging evidence suggests that natural products from pathogenic organisms are i...	Community Requests	2HG4	5.4%	Burkholderia pseudomallei

IDP91805 (show subtarget assignments)	8	selected	No	GBP346_B0724	235002726		putative polyketide synthase PksL (PKS) ...	4567	virulence/pathogenesis / Emerging evidence suggests that natural products from pathogenic organisms are i...	Community Requests	2HG4	5.4%	Burkholderia pseudomallei

IDP02160 (show subtarget assignments)	1	soluble	No	CBU_1245	29541815		GTP-binding protein [Coxiella burnetii R...	443	Conserved; Drug target functions	Phase 3: June 2008	2HJG	38.4%	Coxiella burnetii	Unknown function	General

IDP04530 (show subtarget assignments)	1	soluble	No	STM2519_1_490	16765839	engA	GTP-binding protein EngA [Salmonella typ...	490	Salmonella essential protein	Phase 4: April 2009	2HJG	36.1%	Salmonella enterica

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP91204 (show subtarget assignments)	8	cloned	No	BT_4215	29349623		shikimate 5-dehydrogenase [Bacteroides t...	248	potential drug target / Shikimate pathway enzyme	Community Requests	2HK7	38%	Bacteroides thetaiotaomicron

IDP01104 (show subtarget assignments)	1	soluble	No	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00666 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1096	57285882		TrkA potassium uptake family protein	220	Drug Target Function	Phase 2: March 2008	2HMS	36.4%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP91026 (show subtarget assignments)	8	cloned	No	y3142	22127018		flavodoxin [Yersinia pestis KIM 10]	149	other biological interest / oxidative stress response protein	Community Requests	2HNA	33.6%	Yersinia pestis

IDP00100 (show subtarget assignments)	0	work_stopped	No	NT01SF2345	30041591	cheW	positive regulator of CheA protein activ...	167		Phase 1: October 2007	2HO9	100%	Shigella flexneri	Cellular processes	Chemotaxis and motility

IDP02358 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1667	16121931	cheW	purine-binding chemotaxis protein [Yersi...	165	Conserved; Drug target functions	Phase 3: June 2008	2HO9	83%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP05501 (show subtarget assignments)	1	in_crystallization_trials	No	CD0270	126697842	fliM	putative flagellar motor switch protein ...	293	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HP7	15.7%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90624 (show subtarget assignments)	8	cloned	No	Cj0718	15792067	dnaE	DNA polymerase III subunit alpha [Campyl...	1200	Predicted Essential	Community Requests	2HPI	37%	Campylobacter jejuni

IDP90928 (show subtarget assignments)	8	soluble	No	VC2245	15642243	dnaE	DNA polymerase III subunit alpha [Vibrio...	1164	Predicted Essential	Community Requests	2HQA	62.5%	Vibrio cholerae

IDP90818 (show subtarget assignments)	8	expressed	No	YPO1059	16121359	dnaE	DNA polymerase III subunit alpha [Yersin...	1171	Predicted Essential	Community Requests	2HQA	70%	Yersinia pestis

IDP01123 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4267	30258769	ptsI	phosphoenolpyruvate-protein phosphotrans...	570	Conserved Gene / Pathway	Phase 2: March 2008	2HRO	65.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02361 (show subtarget assignments)	1	expressed	No	CBU_1550	29542109	ptsP	phosphoenolpyruvate-protein phosphotrans...	759	Conserved; Drug target functions	Phase 3: June 2008	2HRO	28.3%	Coxiella burnetii	Signal transduction	PTS

IDP02216 (show subtarget assignments)	1	cloned	No	GBAA1449	47526724		M23/37 family peptidase [Bacillus anthra...	417	Drug target motif; Conserved; Involved in sporulation; Vaccine Target; Drug targ...	Phase 3: June 2008	2HSI	15.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02282 (show subtarget assignments)	1	cloned	No	FTT0491c	56707633	gph	phosphoglycolate phosphatase [Francisell...	224	Drug Target	Phase 3: June 2008	2HSZ	32.6%	Francisella tularensis	Energy metabolism	Sugars

IDP91346 (show subtarget assignments)	8	soluble	No	VV1_3141	27366406		hypothetical protein VV1_3141 [Vibrio vu...	294	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2HTA	35.7%	Vibrio vulnificus

IDP04321 (show subtarget assignments)	1	cloned	No	VC0756	15640775	ndk	nucleoside diphosphate kinase [Vibrio ch...	142	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2HUR	64.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP91595 (show subtarget assignments)	8	selected	No	AAC64366	3661463	arr-2	ribosylating transferase ARR-2 [Pseudomo...	150	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2HW2	51.3%	Pseudomonas aeruginosa

IDP01615 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0643	29541244	ribD	riboflavin biosynthesis protein RibD [Co...	354	Conserved; Drug target functions	Phase 3: June 2008	2HXV	35.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90745 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1622	15792927	ribD	putative riboflavin-specific deaminase [...	336	Predicted Essential	Community Requests	2HXV	28%	Campylobacter jejuni

IDP05202 (show subtarget assignments)	1	cloned	No	CD1700	126699306	ribD	riboflavin biosynthesis protein [Clostri...	367	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HXV	41.4%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01049 (show subtarget assignments)	1	in_crystallization_trials	No	STM3183	16766483	icc	cyclic 3',5'-adenosine monophosphate pho...	275	Conserved Gene / Pathway	Phase 2: March 2008	2HY1	25.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP05329 (show subtarget assignments)	1	soluble	No	BA_0815	30254405		purple acid phosphatase/fibronectin doma...	819	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2HY1	6%	Bacillus anthracis	Unknown function: General

IDP91940 (show subtarget assignments)	8	selected	No	SpneCM_010100006879	298255307		ABC transporter, ATP-binding protein [St...	538	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	25.4%	Streptococcus pneumoniae

IDP91083 (show subtarget assignments)	8	cloned	No	BA_0528	30260686		ABC transporter, ATP-binding/permease pr...	586	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	58.2%	Bacillus anthracis

IDP91072 (show subtarget assignments)	8	cloned	No	YPO2588	16122801	-	putative ABC transport protein	631	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	32.2%	Yersinia pestis

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91080 (show subtarget assignments)	8	cloned	No	Cj0803	6968244	msbA	lipid export ABC transport protein	580	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	31.6%	Campylobacter jejuni

IDP91893 (show subtarget assignments)	8	selected	No	SpneCM_010100003665	298254698		ABC transporter, ATP-binding protein [St...	580	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	34.8%	Streptococcus pneumoniae

IDP91315 (show subtarget assignments)	8	expressed	No	VV2_0482	27366916		ABC-type bacteriocin/lantibiotic exporte...	535	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2HYD	32.7%	Vibrio vulnificus

IDP91070 (show subtarget assignments)	8	cloned	No	RP205	15604078		multidrug resistance transporter ATM1 [R...	609	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	32%	Rickettsia prowazekii

IDP92101 (show subtarget assignments)	8	selected	No	TGME49_032340	237837613		protein phosphatase 2C, putative [Toxopl...	546	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2I0O	17.9%	Toxoplasma gondii

IDP92014 (show subtarget assignments)	8	selected	No	TGME49_067100	237838983		protein phosphatase 2C, putative [Toxopl...	909	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2I0O	10.2%	Toxoplasma gondii

IDP91724 (show subtarget assignments)	8	selected	No	NP_115805	45331215	LZTS2	leucine zipper putative tumor suppressor...	669	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2I1J	10.9%	Homo sapiens

IDP91702 (show subtarget assignments)	8	selected	No	NP_003370	21614499	EZR	ezrin [Homo sapiens]	586	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2I1J	56.9%	Homo sapiens

IDP00124 (show subtarget assignments)	0	work_stopped	No	NT01ST0382	16763693	ghmA	phosphoheptose isomerase	192		Phase 1: October 2007	2I22	97.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90117 (show subtarget assignments)	8	in_crystallization_trials	No	MPXV_ZAI1979_005_027	68449101		virokine protein [Monkeypox virus]	117	similar to VACV-COP-N1L, MPXV-ZAI96-P1L	Community Requests	2I39	89.7%	Monkeypox virus

IDP90206 (show subtarget assignments)	8	soluble	No	MYXV_gp149	9633781	m146R	m146R	108	virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L	Community Requests	2I39	26.9%	Myxoma virus	host defense modulator	0

IDP91430 (show subtarget assignments)	8	cloned	No	VV1_0534	27363997		ATP-dependent RNA helicase SrmB [Vibrio ...	408	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2I4I	32.8%	Vibrio vulnificus

IDP02476 (show subtarget assignments)	1	cloned	No	YPO1776	16122030	dbpA	ATP-dependent RNA helicase DbpA [Yersini...	460	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2I4I	30%	Yersinia pestis	Transcription	Transcription factors

IDP02196 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0734	47526018	thiD-1	phosphomethylpyrimidine kinase [Bacillus...	270	Conserved; Drug target functions	Phase 3: June 2008	2I5B	48.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00630 (show subtarget assignments)	1	cloned	No	SACOL0861	57284322		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	2I5M	71.2%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00623 (show subtarget assignments)	1	cloned	No	SACOL2731	57285285		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	2I5M	68.2%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP05290 (show subtarget assignments)	1	cloned	No	CD0488	126698065	sugE	quaternary ammonium compound-resistance ...	106	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2I68	30.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP00252 (show subtarget assignments)	1	in_crystallization_trials	No		130516		St. Louis encephalitis virus Envelope pr...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	2I69	70.5%	St. Louis

IDP04310 (show subtarget assignments)	1	cloned	No	BAS0231	49183264		D-alanine--D-alanine ligase, C-terminus ...	91	Proposed to be essential proteins	Phase 4: April 2009	2I80	54.9%	Bacillus anthracis

IDP01030 (show subtarget assignments)	1	cloned	No	STM2107	16765437	wcaH	GDP-mannose mannosyl hydrolase	167	Conserved Gene / Pathway	Phase 2: March 2008	2I8T	65.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90988 (show subtarget assignments)	8	expressed	No	y1189	22125092	gltI	glutamate and aspartate transporter subu...	305	other biological interest / -	Community Requests	2IA4	75.7%	Yersinia pestis

IDP04324 (show subtarget assignments)	1	purified	No	CPF_2814	110799621		regulatory protein SpoVG [Clostridium pe...	90	conserved gene; putative drug target function;	Phase 4: April 2009	2IA9	55.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP91363 (show subtarget assignments)	8	expressed	No	VV1_2834	27366116		secreted hydrolase [Vibrio vulnificus CM...	219	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2ICH	28.6%	Vibrio vulnificus

IDP00131 (show subtarget assignments)	0	work_stopped	No	NT01ST2113	16765046	rnb	exoribonuclease II	644	Essential	Phase 1: October 2007	2ID0	90.7%	Salmonella enterica	Transcription	Degradation of RNA

IDP00120 (show subtarget assignments)	1	expressed	No	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP90802 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3769	16123905		3-octaprenyl-4-hydroxybenzoate decarboxy...	498	Predicted Essential	Community Requests	2IDB	88.2%	Yersinia pestis

IDP92097 (show subtarget assignments)	8	selected	No	TGME49_086210	237839921		serine/threonine protein phosphatase, pu...	338	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2IE3	57.4%	Toxoplasma gondii

IDP05633 (show subtarget assignments)	1	purified	No	CD2177	126699793		amino-acid ABC transporter,substrate-bin...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IEE	32.6%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05634 (show subtarget assignments)	1	soluble	No	CD2174	126699790		amino-acid ABC transporter,substrate-bin...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IEE	29.3%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP00325 (show subtarget assignments)	1	crystallized	No	Cj1530	15792838	coaE	dephospho-CoA kinase	201	Drug Target Function	Phase 2: March 2008	2IF2	32.8%	Campylobacter jejuni	Unclassified	Unclassified

IDP92011 (show subtarget assignments)	8	selected	No	TGME49_072210	237833115		hypothetical protein TGME49_072210 [Toxo...	364	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2IFT	12.4%	Toxoplasma gondii

IDP91537 (show subtarget assignments)	8	in_crystallization_trials	No	SAR1789	49483952	ackA	acetate kinase [Staphylococcus aureus su...	400	potential drug target / Protein is a proposed to be a S. aureus (MRSA252) drug target and having crystal...	Community Requests	2IIR	56%	Staphylococcus aureus

IDP91373 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_2221	27365547		acetate kinase [Vibrio vulnificus CMCP6]...	398	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2IIR	47.4%	Vibrio vulnificus

IDP91910
(show subtarget assignments)

8

selected

No

SpneCM_010100003565

298254678

surface protein PspC, partial [Streptoco...

187

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2GRX

25.7%

Streptococcus pneumoniae

IDP01324
(show subtarget assignments)

1

cloned

No

VCA0910

15601664

tonB1 protein

249

Conserved Gene / Pathway

Phase 2: March 2008

2GRX

27.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP91689
(show subtarget assignments)

8

selected

No

NP_000706

4502503

C4BPA

C4b-binding protein alpha chain precurso...

597

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2GSX

28.8%

Homo sapiens

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02806
(show subtarget assignments)

1

cloned

No

Cj1133

15792458

waaC

lipopolysaccharide heptosyltransferase I...

342

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2GT1

23.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90822
(show subtarget assignments)

8

purified

No

YPO0056

16120409

rfaC

ADP-heptose:LPS heptosyl transferase I [...

321

Predicted Essential

Community Requests

2GT1

67.9%

Yersinia pestis

IDP02235
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1105c

56708184

msrA1

bifunctional methionine sulfoxide reduct...

284

Drug Target

Phase 3: June 2008

2GT3

23.2%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP01106
(show subtarget assignments)

1

soluble

No

BA_1846

30256116

msrA-1

peptide methionine sulfoxide reductase

178

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

36%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP01467
(show subtarget assignments)

1

purified

No

VC2549

15642544

methionine sulfoxide reductase A

212

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

56.1%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP92127
(show subtarget assignments)

8

selected

No

TGME49_021310

237841325

aminopeptidase N, putative [Toxoplasma g...

966

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2GTQ

33.6%

Toxoplasma gondii

IDP02031
(show subtarget assignments)

1

cloned

No

lmo2504

16804542

hypothetical protein lmo2504 [Listeria m...

436

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2GU1

17.2%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01897
(show subtarget assignments)

1

expressed

No

STM3038

16766339

putative metalloendopeptidase [Salmonell...

252

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2GU1

18.3%

Salmonella enterica

Cell envelope

Other

IDP00209
(show subtarget assignments)

1

soluble

No

YPO2062

16122301

-

putative M23/M37 peptidase-family protei...

417

Virulence

Phase 1: October 2007

2GU1

32.4%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP02611
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0111

47566431

M23/37 family peptidase [Bacillus anthra...

523

Drug target motif; Vaccine Target

Phase 3: June 2008

2GU1

10.1%

Bacillus anthracis

N/A

IDP00057
(show subtarget assignments)

1

soluble

No

BA_3900

30258414

lantibiotic biosynthesis DNA-binding res...

220

Virulence

Phase 1: October 2007

2GWR

34.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91047
(show subtarget assignments)

8

in_crystallization_trials

No

EFA0003

5353563

vanRD

response regulator [Enterococcus faecium...

232

drug resistance / Component of regulatory system of transcription of vancomycin resistance genes

Community Requests

2GWR

37.1%

Enterococcus faecium

IDP91042
(show subtarget assignments)

8

in_crystallization_trials

No

ACB0002

38230268

AdeR [Acinetobacter baumannii]

247

Regulator protein of transcription of antibiotic drug-efflux pump AdeABC

Community Requests

2GWR

33.2%

Acinetobacter baumannii

IDP04599
(show subtarget assignments)

1

cloned

No

BAS2268

49185277

aspartate-semialdehyde dehydrogenase [Ba...

347

Proposed to be essential proteins

Phase 4: April 2009

2GYY

55.3%

Bacillus anthracis

IDP02467
(show subtarget assignments)

1

soluble

No

GBAA3937

47529228

asd-2

aspartate-semialdehyde dehydrogenase [Ba...

348

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GYY

60.6%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP00018
(show subtarget assignments)

0

work_stopped

No

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00309
(show subtarget assignments)

1

expressed

No

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01786
(show subtarget assignments)

1

expressed

No

CBU_0502

29541107

hydrolase, putative [Coxiella burnetii R...

225

Conserved; Drug target functions

Phase 3: June 2008

2GZX

44.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP04067
(show subtarget assignments)

1

purified

No

BAS4417

49187412

thioredoxin [Bacillus anthracis str. Ste...

104

Proposed to be essential proteins

Phase 4: April 2009

2GZY

75%

Bacillus anthracis

IDP02654
(show subtarget assignments)

1

cloned

No

Cj1682c

15792986

gltA

citrate synthase [Campylobacter jejuni s...

422

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

2H12

50.2%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP90738
(show subtarget assignments)

8

soluble

No

Cj0116

15791504

fabD

malonyl CoA-acyl carrier protein transac...

306

Predicted Essential

Community Requests

2H1Y

49.3%

Campylobacter jejuni

IDP91248
(show subtarget assignments)

8

soluble

No

HP0090

2313169

malonyl coenzyme A-acyl carrier protein ...

309

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2H1Y

98.1%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP02293
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1445

56708487

trxA1

thioredoxin [Francisella tularensis subs...

107

Conserved; Drug target functions

Phase 3: June 2008

2H71

50.5%

Francisella tularensis

Energy metabolism

Electron transport

IDP04639
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0556c

56707686

oxyR

oxidative stress transcriptional regulat...

289

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2H98

26.2%

Francisella tularensis

Regulatory functions

DNA interactions

IDP92556
(show subtarget assignments)

8

selected

No

VV1_1076

27360618

HTH-type transcriptional regulator ilvY ...

296

potential drug target / Proteins are in a pathway we are investigating for playing a role in symbiont nu...

Community Requests

2H99

21.6%

Vibrio vulnificus

IDP00221
(show subtarget assignments)

1

soluble

No

YPO0164

16120507

-

putative membrane receptor protein

686

Virulence

Phase 1: October 2007

2HDF

20.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91021
(show subtarget assignments)

8

cloned

No

y2872

22126749

yiuR

putative outer membrane receptor [Yersin...

665

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

2HDF

38%

Yersinia pestis

IDP00153
(show subtarget assignments)

1

expressed

No

VC0475

15640502

irgA

enterobactin receptor

652

Virulence

Phase 1: October 2007

2HDF

37.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02385
(show subtarget assignments)

1

cloned

No

Cj0755

15792094

cfrA

putative iron uptake protein [Campylobac...

696

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

2HDF

29.8%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP90981
(show subtarget assignments)

8

selected

No

y0850

22124761

outer membrane receptor [Yersinia pestis...

731

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

2HDF

31.1%

Yersinia pestis

IDP01422
(show subtarget assignments)

1

expressed

No

VC1549

15641557

glycerol-3-phosphate ABC transporter, pe...

434

Conserved Gene / Pathway

Phase 2: March 2008

2HEU

20%

Vibrio cholerae

Transport and binding proteins

Other

IDP91638
(show subtarget assignments)

8

expressed

No

NP_216897

15609518

polyketide synthetase MBTD (polyketide s...

1004

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2HG4

15.5%

Mycobacterium tuberculosis

IDP91804
(show subtarget assignments)

8

selected

No

ZP_04523236

237510521

putative polyketide synthase PksL (PKS) ...

4567

virulence/pathogenesis / Emerging evidence suggests that natural products from pathogenic organisms are i...

Community Requests

2HG4

5.4%

Burkholderia pseudomallei

IDP91805
(show subtarget assignments)

8

selected

No

GBP346_B0724

235002726

putative polyketide synthase PksL (PKS) ...

4567

virulence/pathogenesis / Emerging evidence suggests that natural products from pathogenic organisms are i...

Community Requests

2HG4

5.4%

Burkholderia pseudomallei

IDP02160
(show subtarget assignments)

1

soluble

No

CBU_1245

29541815

GTP-binding protein [Coxiella burnetii R...

443

Conserved; Drug target functions

Phase 3: June 2008

2HJG

38.4%

Coxiella burnetii

Unknown function

General

IDP04530
(show subtarget assignments)

1

soluble

No

STM2519_1_490

16765839

engA

GTP-binding protein EngA [Salmonella typ...

490

Salmonella essential protein

Phase 4: April 2009

2HJG

36.1%

Salmonella enterica

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP91204
(show subtarget assignments)

8

cloned

No

BT_4215

29349623

shikimate 5-dehydrogenase [Bacteroides t...

248

potential drug target / Shikimate pathway enzyme

Community Requests

2HK7

38%

Bacteroides thetaiotaomicron

IDP01104
(show subtarget assignments)

1

soluble

No

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00666
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1096

57285882

TrkA potassium uptake family protein

220

Drug Target Function

Phase 2: March 2008

2HMS

36.4%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP91026
(show subtarget assignments)

8

cloned

No

y3142

22127018

flavodoxin [Yersinia pestis KIM 10]

149

other biological interest / oxidative stress response protein

Community Requests

2HNA

33.6%

Yersinia pestis

IDP00100
(show subtarget assignments)

0

work_stopped

No

NT01SF2345

30041591

cheW

positive regulator of CheA protein activ...

167

Phase 1: October 2007

2HO9

100%

Shigella flexneri

Cellular processes

Chemotaxis and motility

IDP02358
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1667

16121931

cheW

purine-binding chemotaxis protein [Yersi...

165

Conserved; Drug target functions

Phase 3: June 2008

2HO9

83%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP05501
(show subtarget assignments)

1

in_crystallization_trials

No

CD0270

126697842

fliM

putative flagellar motor switch protein ...

293

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HP7

15.7%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90624
(show subtarget assignments)

8

cloned

No

Cj0718

15792067

dnaE

DNA polymerase III subunit alpha [Campyl...

1200

Predicted Essential

Community Requests

2HPI

37%

Campylobacter jejuni

IDP90928
(show subtarget assignments)

8

soluble

No

VC2245

15642243

dnaE

DNA polymerase III subunit alpha [Vibrio...

1164

Predicted Essential

Community Requests

2HQA

62.5%

Vibrio cholerae

IDP90818
(show subtarget assignments)

8

expressed

No

YPO1059

16121359

dnaE

DNA polymerase III subunit alpha [Yersin...

1171

Predicted Essential

Community Requests

2HQA

70%

Yersinia pestis

IDP01123
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4267

30258769

ptsI

phosphoenolpyruvate-protein phosphotrans...

570

Conserved Gene / Pathway

Phase 2: March 2008

2HRO

65.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02361
(show subtarget assignments)

1

expressed

No

CBU_1550

29542109

ptsP

phosphoenolpyruvate-protein phosphotrans...

759

Conserved; Drug target functions

Phase 3: June 2008

2HRO

28.3%

Coxiella burnetii

Signal transduction

PTS

IDP02216
(show subtarget assignments)

1

cloned

No

GBAA1449

47526724

M23/37 family peptidase [Bacillus anthra...

417

Drug target motif; Conserved; Involved in sporulation; Vaccine Target; Drug targ...

Phase 3: June 2008

2HSI

15.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02282
(show subtarget assignments)

1

cloned

No

FTT0491c

56707633

gph

phosphoglycolate phosphatase [Francisell...

224

Drug Target

Phase 3: June 2008

2HSZ

32.6%

Francisella tularensis

Energy metabolism

Sugars

IDP91346
(show subtarget assignments)

8

soluble

No

VV1_3141

27366406

hypothetical protein VV1_3141 [Vibrio vu...

294

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2HTA

35.7%

Vibrio vulnificus

IDP04321
(show subtarget assignments)

1

cloned

No

VC0756

15640775

ndk

nucleoside diphosphate kinase [Vibrio ch...

142

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2HUR

64.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP91595
(show subtarget assignments)

8

selected

No

AAC64366

3661463

arr-2

ribosylating transferase ARR-2 [Pseudomo...

150

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2HW2

51.3%

Pseudomonas aeruginosa

IDP01615
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0643

29541244

ribD

riboflavin biosynthesis protein RibD [Co...

354

Conserved; Drug target functions

Phase 3: June 2008

2HXV

35.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90745
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1622

15792927

ribD

putative riboflavin-specific deaminase [...

336

Predicted Essential

Community Requests

2HXV

28%

Campylobacter jejuni

IDP05202
(show subtarget assignments)

1

cloned

No

CD1700

126699306

ribD

riboflavin biosynthesis protein [Clostri...

367

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HXV

41.4%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01049
(show subtarget assignments)

1

in_crystallization_trials

No

STM3183

16766483

icc

cyclic 3',5'-adenosine monophosphate pho...

275

Conserved Gene / Pathway

Phase 2: March 2008

2HY1

25.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP05329
(show subtarget assignments)

1

soluble

No

BA_0815

30254405

purple acid phosphatase/fibronectin doma...

819

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2HY1

6%

Bacillus anthracis

Unknown function: General

IDP91940
(show subtarget assignments)

8

selected

No

SpneCM_010100006879

298255307

ABC transporter, ATP-binding protein [St...

538

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

25.4%

Streptococcus pneumoniae

IDP91083
(show subtarget assignments)

8

cloned

No

BA_0528

30260686

ABC transporter, ATP-binding/permease pr...

586

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

58.2%

Bacillus anthracis

IDP91072
(show subtarget assignments)

8

cloned

No

YPO2588

16122801

-

putative ABC transport protein

631

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

32.2%

Yersinia pestis

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91080
(show subtarget assignments)

8

cloned

No

Cj0803

6968244

msbA

lipid export ABC transport protein

580

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

31.6%

Campylobacter jejuni

IDP91893
(show subtarget assignments)

8

selected

No

SpneCM_010100003665

298254698

ABC transporter, ATP-binding protein [St...

580

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

34.8%

Streptococcus pneumoniae

IDP91315
(show subtarget assignments)

8

expressed

No

VV2_0482

27366916

ABC-type bacteriocin/lantibiotic exporte...

535

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2HYD

32.7%

Vibrio vulnificus

IDP91070
(show subtarget assignments)

8

cloned

No

RP205

15604078

multidrug resistance transporter ATM1 [R...

609

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

32%

Rickettsia prowazekii

IDP92101
(show subtarget assignments)

8

selected

No

TGME49_032340

237837613

protein phosphatase 2C, putative [Toxopl...

546

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2I0O

17.9%

Toxoplasma gondii

IDP92014
(show subtarget assignments)

8

selected

No

TGME49_067100

237838983

protein phosphatase 2C, putative [Toxopl...

909

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2I0O

10.2%

Toxoplasma gondii

IDP91724
(show subtarget assignments)

8

selected

No

NP_115805

45331215

LZTS2

leucine zipper putative tumor suppressor...

669

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2I1J

10.9%

Homo sapiens

IDP91702
(show subtarget assignments)

8

selected

No

NP_003370

21614499

EZR

ezrin [Homo sapiens]

586

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2I1J

56.9%

Homo sapiens

IDP00124
(show subtarget assignments)

0

work_stopped

No

NT01ST0382

16763693

ghmA

phosphoheptose isomerase

192

Phase 1: October 2007

2I22

97.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90117
(show subtarget assignments)

8

in_crystallization_trials

No

MPXV_ZAI1979_005_027

68449101

virokine protein [Monkeypox virus]

117

similar to VACV-COP-N1L, MPXV-ZAI96-P1L

Community Requests

2I39

89.7%

Monkeypox virus

IDP90206
(show subtarget assignments)

8

soluble

No

MYXV_gp149

9633781

m146R

108

virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L

Community Requests

2I39

26.9%

Myxoma virus

host defense modulator

0

IDP91430
(show subtarget assignments)

8

cloned

No

VV1_0534

27363997

ATP-dependent RNA helicase SrmB [Vibrio ...

408

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2I4I

32.8%

Vibrio vulnificus

IDP02476
(show subtarget assignments)

1

cloned

No

YPO1776

16122030

dbpA

ATP-dependent RNA helicase DbpA [Yersini...

460

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2I4I

30%

Yersinia pestis

Transcription

Transcription factors

IDP02196
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0734

47526018

thiD-1

phosphomethylpyrimidine kinase [Bacillus...

270

Conserved; Drug target functions

Phase 3: June 2008

2I5B

48.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00630
(show subtarget assignments)

1

cloned

No

SACOL0861

57284322

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

2I5M

71.2%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00623
(show subtarget assignments)

1

cloned

No

SACOL2731

57285285

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

2I5M

68.2%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP05290
(show subtarget assignments)

1

cloned

No

CD0488

126698065

sugE

quaternary ammonium compound-resistance ...

106

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2I68

30.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP00252
(show subtarget assignments)

1

in_crystallization_trials

No

130516

St. Louis encephalitis virus Envelope pr...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

2I69

70.5%

St. Louis

IDP04310
(show subtarget assignments)

1

cloned

No

BAS0231

49183264

D-alanine--D-alanine ligase, C-terminus ...

91

Proposed to be essential proteins

Phase 4: April 2009

2I80

54.9%

Bacillus anthracis

IDP01030
(show subtarget assignments)

1

cloned

No

STM2107

16765437

wcaH

GDP-mannose mannosyl hydrolase

167

Conserved Gene / Pathway

Phase 2: March 2008

2I8T

65.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90988
(show subtarget assignments)

8

expressed

No

y1189

22125092

gltI

glutamate and aspartate transporter subu...

305

other biological interest / -

Community Requests

2IA4

75.7%

Yersinia pestis

IDP04324
(show subtarget assignments)

1

purified

No

CPF_2814

110799621

regulatory protein SpoVG [Clostridium pe...

90

conserved gene; putative drug target function;

Phase 4: April 2009

2IA9

55.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP91363
(show subtarget assignments)

8

expressed

No

VV1_2834

27366116

secreted hydrolase [Vibrio vulnificus CM...

219

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2ICH

28.6%

Vibrio vulnificus

IDP00131
(show subtarget assignments)

0

work_stopped

No

NT01ST2113

16765046

rnb

exoribonuclease II

644

Essential

Phase 1: October 2007

2ID0

90.7%

Salmonella enterica

Transcription

Degradation of RNA

IDP00120
(show subtarget assignments)

1

expressed

No

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP90802
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3769

16123905

3-octaprenyl-4-hydroxybenzoate decarboxy...

498

Predicted Essential

Community Requests

2IDB

88.2%

Yersinia pestis

IDP92097
(show subtarget assignments)

8

selected

No

TGME49_086210

237839921

serine/threonine protein phosphatase, pu...

338

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2IE3

57.4%

Toxoplasma gondii

IDP05633
(show subtarget assignments)

1

purified

No

CD2177

126699793

amino-acid ABC transporter,substrate-bin...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IEE

32.6%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05634
(show subtarget assignments)

1

soluble

No

CD2174

126699790

amino-acid ABC transporter,substrate-bin...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IEE

29.3%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP00325
(show subtarget assignments)

1

crystallized

No

Cj1530

15792838

coaE

dephospho-CoA kinase

201

Drug Target Function

Phase 2: March 2008

2IF2

32.8%

Campylobacter jejuni

Unclassified

IDP92011
(show subtarget assignments)

8

selected

No

TGME49_072210

237833115

hypothetical protein TGME49_072210 [Toxo...

364

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2IFT

12.4%

Toxoplasma gondii

IDP91537
(show subtarget assignments)

8

in_crystallization_trials

No

SAR1789

49483952

ackA

acetate kinase [Staphylococcus aureus su...

400

potential drug target / Protein is a proposed to be a S. aureus (MRSA252) drug target and having crystal...

Community Requests

2IIR

56%

Staphylococcus aureus

IDP91373
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_2221

27365547

acetate kinase [Vibrio vulnificus CMCP6]...

398

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2IIR

47.4%

Vibrio vulnificus