Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90162 (show subtarget assignments)	8	purified	No	CD1833	123174272		3-dehydroquinate synthase	354	Potential drug target. Shikimate pathway enzyme	Community Requests	3OKF	40.1%	Clostridium difficile

IDP02230 (show subtarget assignments)	1	cloned	No	YPO0829	16121138		putative sulfatase [Yersinia pestis CO92...	517	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2QZU	40.2%	Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP91268 (show subtarget assignments)	8	soluble	No	NT05BA2906	49179679		histidinol-phosphate aminotransferase [B...	366	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3FFH	40.2%	Bacillus anthracis

IDP05578 (show subtarget assignments)	1	cloned	No	SACOL1710	57650536	valS	valyl-tRNA synthetase [Staphylococcus au...	876	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	40.2%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP01469 (show subtarget assignments)	1	purified	No	VC2568	15642563		peptidyl-prolyl cis-trans isomerase, FKB...	209	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP90858 (show subtarget assignments)	8	in_crystallization_trials	No	O31153	30179879		Glutamyl-tRNA synthetase (Glutamate--tRN...	474	Predicted Essential	Community Requests	2CFO	40.2%	Vibrio cholerae

IDP00647 (show subtarget assignments)	1	selected	No	SACOL1657	57286179		enterotoxin type A, putative	234	Virulence Associated Factor	Phase 2: March 2008	1ESF	40.2%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00066 (show subtarget assignments)	1	expressed	No	NTL01CJ00766	6968259	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	239	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2Y6P	40.2%	Campylobacter jejuni	Protein synthesis	tRNA aminoacylation

IDP90708 (show subtarget assignments)	8	cloned	No	Cj0955c	15792284	purL	phosphoribosylformylglycinamidine syntha...	728	Predicted Essential	Community Requests	3AC6	40.2%	Campylobacter jejuni

IDP91809 (show subtarget assignments)	8	selected	No	ZEBOVgp2	10313992	VP35	VP35 [Zaire ebolavirus]	340	Justification: Zaire ebolavirus belongs to the Filoviruses genus, on which struc...	Community Requests	3KS4	40.3%	Zaire ebolavirus

IDP01104 (show subtarget assignments)	1	soluble	No	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01085 (show subtarget assignments)	1	in_crystallization_trials	No	STM4397	161353572	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans...	206	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP04270 (show subtarget assignments)	1	cloned	No	CPF_2226	110799081	potD	spermidine/putrescine ABC transporter, s...	360	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EQB	40.3%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP02097 (show subtarget assignments)	1	cloned	No	Cj0195	15791582	fliI	flagellum-specific ATP synthase [Campylo...	461	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	2DPY	40.3%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP90859 (show subtarget assignments)	8	expressed	No	Cj1494c	15792809	carA	carbamoyl phosphate synthase small subun...	372	Predicted Essential	Community Requests	1BXR	40.3%	Campylobacter jejuni

IDP04671 (show subtarget assignments)	1	soluble	No	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP04644 (show subtarget assignments)	1	cloned	No	FTT0895	56707996	purN	phosphoribosylglycinamide formyltransfer...	191	conserved gene;	Phase 4: April 2009	1C2T	40.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01686 (show subtarget assignments)	1	cloned	No	Cj0804	15792142	pyrD	dihydroorotate dehydrogenase 2 [Campylob...	352	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1UUM	40.3%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP90778 (show subtarget assignments)	8	soluble	No	Cj0575	15791935	ilvH	acetolactate synthase 3 regulatory subun...	154	Predicted Essential	Community Requests	2F1F	40.3%	Campylobacter jejuni

IDP02624 (show subtarget assignments)	1	soluble	No	FTT1562	56708589	ispA	geranyltranstransferase [Francisella tul...	293	Conserved; Drug target functions	Phase 3: June 2008	2FOR	40.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00739 (show subtarget assignments)	1	diffraction	No	SACOL1063	57284433		acetyltransferase, GNAT family	144	Drug Target Function	Phase 2: March 2008	1Q2Y	40.3%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP00016 (show subtarget assignments)	1	crystallized	No	BA_4053	46576983		UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	491	Drug Target Homolog	Phase 1: October 2007	2WTZ	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90294 (show subtarget assignments)	8	expressed	No	TGME49_113230	211962198		eukaryotic translation initiation factor...	347	Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...	Community Requests	1Q8K	40.3%	Toxoplasma gondii

IDP91492 (show subtarget assignments)	8	purified	No	VP1693	28898467		putative type III secretion protein [Vib...	119	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2P58	40.3%	Vibrio parahaemolyticus

IDP01219 (show subtarget assignments)	1	purified	No	BA_3767	30258283		prophage LambdaBa01, N-acetylmuramoyl-L-...	310	Drug Target Function	Phase 2: March 2008	2L47	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05559 (show subtarget assignments)	1	soluble	No	lmo1811	16803851	-	hypothetical protein lmo1811 [Listeria m...	697	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GM5	40.3%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP90136 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_177	68449248		ser/thr kinase [Monkeypox virus]	299	essential for viral DNA replication, similar to VACV-COP-B1R, MPXV-ZAI96-B3R	Community Requests	2V62	40.4%	Monkeypox virus

IDP02054 (show subtarget assignments)	1	purified	No	FTT0623	56707748	tig	trigger factor [Francisella tularensis s...	438	Conserved; Drug target functions	Phase 3: June 2008	1W26	40.4%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02030 (show subtarget assignments)	1	expressed	No	CBU_1255	29541825		geranyltranstransferase, putative [Coxie...	267	Conserved; Drug target functions	Phase 3: June 2008	3TS7	40.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90827 (show subtarget assignments)	8	expressed	No	Cj0514	15791876	purQ	phosphoribosylformylglycinamidine syntha...	223	Predicted Essential	Community Requests	3D54	40.4%	Campylobacter jejuni

IDP02704 (show subtarget assignments)	1	soluble	No	lmo0007	16802055	gyrA	DNA gyrase subunit A [Listeria monocytog...	842	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2XCO	40.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP00713 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1108	57285894		spermidine/putrescine ABC transporter, A...	364	Conserved Gene / Pathway	Phase 2: March 2008	2D62	40.4%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00317 (show subtarget assignments)	1	cloned	No	CBU_1887	29655172	ponA	penicillin-binding protein 1A	793	Drug Target Function	Phase 2: March 2008	3UDF	40.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00105 (show subtarget assignments)	1	purified	No	NT01SF3662	30042589	S3225	putative class II aminotransferase	116	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2X8U	40.5%	Shigella flexneri	Central intermediary metabolism	Other

IDP90739 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0772c	15792110		lipoprotein, NLPA family [Campylobacter ...	257	Predicted Essential	Community Requests	4EF1	40.5%	Campylobacter jejuni

IDP02613 (show subtarget assignments)	1	expressed	No	YPO3530	16123676	cpdB	bifunctional 2',3'-cyclic nucleotide 2'-...	656	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3JYF	40.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP90598 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3443	16123591	valS	valyl-tRNA synthetase [Yersinia pestis C...	965	Predicted Essential	Community Requests	1GAX	40.5%	Yersinia pestis

IDP02417 (show subtarget assignments)	1	cloned	No	FTT0812	56707923	gcvH1	glycine cleavage system protein H [Franc...	126	Conserved; Drug target functions	Phase 3: June 2008	1ZKO	40.5%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP00139 (show subtarget assignments)	1	crystallized	No	BA_4355	30258855	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1VKN	40.5%	Bacillus anthracis	Unknown function	General

IDP02108 (show subtarget assignments)	1	in_crystallization_trials	No	STM3680	16766965	aldB	aldehyde dehydrogenase B [Salmonella typ...	512	Conserved; Drug target functions	Phase 3: June 2008	1NZW	40.6%	Salmonella enterica	Energy metabolism	Other

IDP01996 (show subtarget assignments)	1	in_crystallization_trials	No	STM3136	16766436		putative D-mannonate oxidoreductase [Sal...	490	Conserved; Drug target functions	Phase 3: June 2008	1LJ8	40.6%	Salmonella enterica	Energy metabolism	Other

IDP02762 (show subtarget assignments)	1	cloned	No	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01931 (show subtarget assignments)	1	soluble	No	CBU_0073	29540696		peptidase, M24 family protein [Coxiella ...	597	Conserved; Drug target functions	Phase 3: June 2008	3CTZ	40.6%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91728 (show subtarget assignments)	8	selected	No	NP_647593	21536400	BIN1	myc box-dependent-interacting protein 1 ...	593	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2FIC	40.6%	Homo sapiens

IDP02696 (show subtarget assignments)	1	soluble	No	GBAA2773	47528064	acoL	dihydrolipoamide dehydrogenase [Bacillus...	459	Conserved; Drug target functions	Phase 3: June 2008	2QAE	40.6%	Bacillus anthracis	Energy metabolism	Fermentation

IDP91823 (show subtarget assignments)	8	soluble	No	b1854	1788160	pykA	pyruvate kinase II [Escherichia coli str...	480	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	2E28	40.6%	Escherichia coli

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP01306 (show subtarget assignments)	1	purified	No	VC1281	15641294		PTS system, cellobiose-specific IIB comp...	101	Conserved Gene / Pathway	Phase 2: March 2008	2L2Q	40.6%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04042 (show subtarget assignments)	1	cloned	No	CPF_0296	110798725		putative cell division ATP-binding prote...	228	conserved gene; putative drug target function;	Phase 4: April 2009	1F3O	40.6%	Clostridium perfringens	Cellular processes	Cell division

IDP00627 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0552	57285570		hypothetical protein SACOL0552	133	Conserved Gene / Pathway	Phase 2: March 2008	2K4K	40.6%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP91962 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100007760	298255480		amino acid ABC transporter, amino acid-b...	266	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	4EQ9	40.6%	Streptococcus pneumoniae

IDP90192 (show subtarget assignments)	8	cloned	No	AAM13635.1	20153174	CPXV196 CDS	CPXV196 protein	299	serine-threonine kinase	Community Requests	2KTY	40.7%	Cowpox virus	Unknown function	0

IDP02122 (show subtarget assignments)	1	cloned	No	CBU_0090	29540712	tolB	tolB protein [Coxiella burnetii RSA 493]...	437	Conserved; Drug target functions	Phase 3: June 2008	1C5K	40.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP04459 (show subtarget assignments)	1	cloned	No	YPO1472	115347226		conserved hypothetical protein [Yersinia...	782	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	40.7%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP05772 (show subtarget assignments)	1	cloned	No	Z3171	12516188	dacD	penicillin binding protein 6b [Escherich...	425	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZO	40.7%	Escherichia coli	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90753 (show subtarget assignments)	8	crystallized	No	Cj0586	15791946	ligA	NAD-dependent DNA ligase LigA [Campyloba...	647	Predicted Essential	Community Requests	2OWO	40.7%	Campylobacter jejuni

IDP02605 (show subtarget assignments)	1	cloned	No	YPO3502	16123648	hflB	ATP-dependent metalloprotease [Yersinia ...	644	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	2DHR	40.7%	Yersinia pestis	Cellular processes	Cell division

IDP91903 (show subtarget assignments)	8	selected	No	SpneCM_010100005798	298255108		hypothetical protein SpneCM_05798 [Strep...	663	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2DHR	40.7%	Streptococcus pneumoniae

IDP00337 (show subtarget assignments)	1	expressed	No	FTT0946	56708043	trpG	anthranilate synthase component II	184	Drug Target Function	Phase 2: March 2008	1QDL	40.7%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP92103 (show subtarget assignments)	8	selected	No	TGME49_097970	237843837		aspartyl aminopeptidase, putative [Toxop...	506	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3VAR	40.7%	Toxoplasma gondii

IDP04314 (show subtarget assignments)	1	purified	No	YPCD1.73c	5832493	YPCD1.73c	hypothetical protein YPCD1.73c [Yersinia...	149	virulence factor; conserved gene;	Phase 4: April 2009	1JSC	40.7%	Yersinia pestis

IDP01201 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1826	34098434		3-oxoacyl-[acyl-carrier-protein] synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	40.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02401 (show subtarget assignments)	1	cloned	No	Cj0574	15791934	ilvI	acetolactate synthase 3 catalytic subuni...	566	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1JSC	40.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00612 (show subtarget assignments)	1	purified	No	SACOL0582	57285598	nusG	transcription antitermination protein Nu...	182	Drug Target Function	Phase 2: March 2008	2JVV	40.7%	Staphylococcus aureus	Transcription	Transcription factors

IDP02318 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1251	47526517	trpC	indole-3-glycerol-phosphate synthase [Ba...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TSM	40.7%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02826 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4254	47529547		transaminase [Bacillus anthracis str. 'A...	392	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	2O1B	40.8%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP05510 (show subtarget assignments)	1	soluble	No	CD1303	126698901		NAD-dependent deacetylase [Clostridium d...	245	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MA3	40.8%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01757 (show subtarget assignments)	1	purified	No	YPO3509	16123655	obgE	GTPase ObgE [Yersinia pestis CO92]	390	Conserved; CD; Drug target functions	Phase 3: June 2008	1LNZ	40.8%	Yersinia pestis	Unknown function	General

IDP02665 (show subtarget assignments)	1	cloned	No	FTT0469	56707611	ksgA	dimethyladenosine transferase [Francisel...	262	Conserved; Drug target functions	Phase 3: June 2008	3TQS	40.8%	Francisella tularensis	Cellular processesProtein synthesis	Toxin production and resistancetRNA and rRNA base modification

IDP04167 (show subtarget assignments)	1	cloned	No	VC1977	9656518		aspartate aminotransferase, putative [Vi...	404	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XI9	40.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP05579 (show subtarget assignments)	1	soluble	No	BA_0855	30254440		amino acid ABC transporter, amino acid-b...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2YLN	40.8%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04309 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0050	49183085		peptidyl-tRNA hydrolase [Bacillus anthra...	186	Proposed to be essential proteins	Phase 4: April 2009	3KJZ	40.9%	Bacillus anthracis

IDP02822 (show subtarget assignments)	1	cloned	No	GBAA4819	47778330	infC	translation initiation factor IF-3 [Baci...	186	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TIG	40.9%	Bacillus anthracis	Protein synthesis	Translation factors

IDP05425 (show subtarget assignments)	1	soluble	No	lmo0355	16802400	-	fumarate reductase flavoprotein subunit ...	506	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1D4C	40.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP90202 (show subtarget assignments)	8	cloned	No	AAM13655.1	20153194	CPXV217 CDS	CPXV217 protein	372	serine-protease inhibitor (SPI-1)	Community Requests	1F0C	40.9%	Cowpox virus	host defense modulator	0

IDP01010 (show subtarget assignments)	1	purified	No	STM2539	16765859	hscA	chaperone protein HscA	616	Conserved Gene / Pathway	Phase 2: March 2008	2KHO	40.9%	Salmonella enterica	Protein fate	Protein folding and stabilization

IDP04016 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0834	110798754	arsC	arsenate reductase ArsC [Clostridium per...	132	conserved gene; putative drug target function;	Phase 4: April 2009	2L17	40.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP01753 (show subtarget assignments)	1	expressed	No	CBU_0423	29541032	panC	pantoate--beta-alanine ligase [Coxiella ...	257	Conserved; Drug target functions	Phase 3: June 2008	3N8H	40.9%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00768 (show subtarget assignments)	0	work_stopped	No	SACOL0470	57285497		superantigen-like protein	352	Virulence Associated Factor	Phase 2: March 2008	3URY	40.9%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01493 (show subtarget assignments)	1	diffraction	No	VCA0751	161582040		3-oxoacyl-(acyl carrier protein) synthas...	362	Drug Target Function	Phase 2: March 2008	2EBD	40.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90854 (show subtarget assignments)	8	crystallized	No	Cj1727c	15793030	metY	putative O-acetylhomoserine (thiol)-lyas...	423	Predicted Essential	Community Requests	2CTZ	40.9%	Campylobacter jejuni

IDP01396 (show subtarget assignments)	1	purified	No	VC0752	15640771	hscA	chaperone protein HscA	616	Conserved Gene / Pathway	Phase 2: March 2008	2KHO	40.9%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP91016 (show subtarget assignments)	8	selected	No	y2451	22126334		hypothetical protein y2451 [Yersinia pes...	384	other biological interest / putative iron transport protein	Community Requests	3AT7	40.9%	Yersinia pestis

IDP02370 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1958	47527254	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	242	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3OEC	40.9%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02141 (show subtarget assignments)	1	purified	No	CBU_0737	29541337	tig	trigger factor [Coxiella burnetii RSA 49...	442	Conserved; Drug target functions	Phase 3: June 2008	1W26	41%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP00257 (show subtarget assignments)	1	in_crystallization_trials	No	MODVgp1	20177456		Modoc virus Envelope protein	393	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1SVB	41%	Modoc virus

IDP01852 (show subtarget assignments)	1	cloned	No	GBAA5449	47530763	celA-3	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02705 (show subtarget assignments)	1	cloned	No	lmo0202	16802248	hly	listeriolysin O precursor [Listeria mono...	529	Known virulence-Toxin; Predicted virulence-Pathogenicity islands; PMID:11901162	Phase 3: June 2008	3HVN	41%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP00719 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1457	57284566		PTS system, IIA component	166	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	41%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05512 (show subtarget assignments)	1	cloned	No	CD1601	126699205	thiE1	thiamine-phosphate pyrophosphorylase [Cl...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XI3	41%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00620 (show subtarget assignments)	1	cloned	No	SACOL0937	57285812	dltC	D-alanine--poly(phosphoribitol) ligase s...	78	Conserved Gene / Pathway	Phase 2: March 2008	1DV5	41%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05547 (show subtarget assignments)	1	soluble	No	lmo0285	16802331	-	putative lipoprotein [Listeria monocytog...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQW	41%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP02234 (show subtarget assignments)	1	cloned	No	FTT1094c	56708177		cytosol aminopeptidase family protein [F...	471	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IJ3	41.1%	Francisella tularensis	N/A	N/A

IDP04407 (show subtarget assignments)	1	cloned	No	CPF_0677	110799553	purH	bifunctional phosphoribosylaminoimidazol...	501	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	41.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01847 (show subtarget assignments)	1	soluble	No	GBAA5416	47530729	ftsE	cell division ABC transporter, ATP-bindi...	214	Conserved; Drug target functions	Phase 3: June 2008	3DHW	41.1%	Bacillus anthracis	Cellular processes	Cell division

IDP90005 (show subtarget assignments)	8	soluble	No	Z4377	12517595	qseB	quorum sensing Escherichia coli regulato...	219	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3Q9S	41.1%	Escherichia coli

IDP91359 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_2847	27366129		response regulator [Vibrio vulnificus CM...	219	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1KGS	41.1%	Vibrio vulnificus

IDP92087 (show subtarget assignments)	8	selected	No	TGME49_116330	237831005		iron-containing superoxide dismutase [To...	287	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2AWP	41.1%	Toxoplasma gondii

IDP02323 (show subtarget assignments)	1	soluble	No	FTT0560c	56707690	serC	phosphoserine aminotransferase [Francise...	350	Drug Target	Phase 3: June 2008	3QBO	41.1%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism	Aspartate familyOther

IDP90162
(show subtarget assignments)

8

purified

No

CD1833

123174272

3-dehydroquinate synthase

354

Potential drug target. Shikimate pathway enzyme

Community Requests

3OKF

40.1%

Clostridium difficile

IDP02230
(show subtarget assignments)

1

cloned

No

YPO0829

16121138

putative sulfatase [Yersinia pestis CO92...

517

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2QZU

40.2%

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP91268
(show subtarget assignments)

8

soluble

No

NT05BA2906

49179679

histidinol-phosphate aminotransferase [B...

366

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3FFH

40.2%

Bacillus anthracis

IDP05578
(show subtarget assignments)

1

cloned

No

SACOL1710

57650536

valS

valyl-tRNA synthetase [Staphylococcus au...

876

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

40.2%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP01469
(show subtarget assignments)

1

purified

No

VC2568

15642563

peptidyl-prolyl cis-trans isomerase, FKB...

209

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP90858
(show subtarget assignments)

8

in_crystallization_trials

No

O31153

30179879

Glutamyl-tRNA synthetase (Glutamate--tRN...

474

Predicted Essential

Community Requests

2CFO

40.2%

Vibrio cholerae

IDP00647
(show subtarget assignments)

1

selected

No

SACOL1657

57286179

enterotoxin type A, putative

234

Virulence Associated Factor

Phase 2: March 2008

1ESF

40.2%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00066
(show subtarget assignments)

1

expressed

No

NTL01CJ00766

6968259

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

239

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2Y6P

40.2%

Campylobacter jejuni

Protein synthesis

tRNA aminoacylation

IDP90708
(show subtarget assignments)

8

cloned

No

Cj0955c

15792284

purL

phosphoribosylformylglycinamidine syntha...

728

Predicted Essential

Community Requests

3AC6

40.2%

Campylobacter jejuni

IDP91809
(show subtarget assignments)

8

selected

No

ZEBOVgp2

10313992

VP35

VP35 [Zaire ebolavirus]

340

Justification: Zaire ebolavirus belongs to the Filoviruses genus, on which struc...

Community Requests

3KS4

40.3%

Zaire ebolavirus

IDP01104
(show subtarget assignments)

1

soluble

No

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01085
(show subtarget assignments)

1

in_crystallization_trials

No

STM4397

161353572

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans...

206

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP04270
(show subtarget assignments)

1

cloned

No

CPF_2226

110799081

potD

spermidine/putrescine ABC transporter, s...

360

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EQB

40.3%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP02097
(show subtarget assignments)

1

cloned

No

Cj0195

15791582

fliI

flagellum-specific ATP synthase [Campylo...

461

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

2DPY

40.3%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP90859
(show subtarget assignments)

8

expressed

No

Cj1494c

15792809

carA

carbamoyl phosphate synthase small subun...

372

Predicted Essential

Community Requests

1BXR

40.3%

Campylobacter jejuni

IDP04671
(show subtarget assignments)

1

soluble

No

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP04644
(show subtarget assignments)

1

cloned

No

FTT0895

56707996

purN

phosphoribosylglycinamide formyltransfer...

191

conserved gene;

Phase 4: April 2009

1C2T

40.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01686
(show subtarget assignments)

1

cloned

No

Cj0804

15792142

pyrD

dihydroorotate dehydrogenase 2 [Campylob...

352

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1UUM

40.3%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP90778
(show subtarget assignments)

8

soluble

No

Cj0575

15791935

ilvH

acetolactate synthase 3 regulatory subun...

154

Predicted Essential

Community Requests

2F1F

40.3%

Campylobacter jejuni

IDP02624
(show subtarget assignments)

1

soluble

No

FTT1562

56708589

ispA

geranyltranstransferase [Francisella tul...

293

Conserved; Drug target functions

Phase 3: June 2008

2FOR

40.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00739
(show subtarget assignments)

1

diffraction

No

SACOL1063

57284433

acetyltransferase, GNAT family

144

Drug Target Function

Phase 2: March 2008

1Q2Y

40.3%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP00016
(show subtarget assignments)

1

crystallized

No

BA_4053

46576983

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

491

Drug Target Homolog

Phase 1: October 2007

2WTZ

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90294
(show subtarget assignments)

8

expressed

No

TGME49_113230

211962198

eukaryotic translation initiation factor...

347

Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...

Community Requests

1Q8K

40.3%

Toxoplasma gondii

IDP91492
(show subtarget assignments)

8

purified

No

VP1693

28898467

putative type III secretion protein [Vib...

119

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2P58

40.3%

Vibrio parahaemolyticus

IDP01219
(show subtarget assignments)

1

purified

No

BA_3767

30258283

prophage LambdaBa01, N-acetylmuramoyl-L-...

310

Drug Target Function

Phase 2: March 2008

2L47

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05559
(show subtarget assignments)

1

soluble

No

lmo1811

16803851

-

hypothetical protein lmo1811 [Listeria m...

697

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GM5

40.3%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP90136
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_177

68449248

ser/thr kinase [Monkeypox virus]

299

essential for viral DNA replication, similar to VACV-COP-B1R, MPXV-ZAI96-B3R

Community Requests

2V62

40.4%

Monkeypox virus

IDP02054
(show subtarget assignments)

1

purified

No

FTT0623

56707748

tig

trigger factor [Francisella tularensis s...

438

Conserved; Drug target functions

Phase 3: June 2008

1W26

40.4%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02030
(show subtarget assignments)

1

expressed

No

CBU_1255

29541825

geranyltranstransferase, putative [Coxie...

267

Conserved; Drug target functions

Phase 3: June 2008

3TS7

40.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90827
(show subtarget assignments)

8

expressed

No

Cj0514

15791876

purQ

phosphoribosylformylglycinamidine syntha...

223

Predicted Essential

Community Requests

3D54

40.4%

Campylobacter jejuni

IDP02704
(show subtarget assignments)

1

soluble

No

lmo0007

16802055

gyrA

DNA gyrase subunit A [Listeria monocytog...

842

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2XCO

40.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP00713
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1108

57285894

spermidine/putrescine ABC transporter, A...

364

Conserved Gene / Pathway

Phase 2: March 2008

2D62

40.4%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00317
(show subtarget assignments)

1

cloned

No

CBU_1887

29655172

ponA

penicillin-binding protein 1A

793

Drug Target Function

Phase 2: March 2008

3UDF

40.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00105
(show subtarget assignments)

1

purified

No

NT01SF3662

30042589

S3225

putative class II aminotransferase

116

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2X8U

40.5%

Shigella flexneri

Central intermediary metabolism

Other

IDP90739
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0772c

15792110

lipoprotein, NLPA family [Campylobacter ...

257

Predicted Essential

Community Requests

4EF1

40.5%

Campylobacter jejuni

IDP02613
(show subtarget assignments)

1

expressed

No

YPO3530

16123676

cpdB

bifunctional 2',3'-cyclic nucleotide 2'-...

656

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3JYF

40.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP90598
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3443

16123591

valS

valyl-tRNA synthetase [Yersinia pestis C...

965

Predicted Essential

Community Requests

1GAX

40.5%

Yersinia pestis

IDP02417
(show subtarget assignments)

1

cloned

No

FTT0812

56707923

gcvH1

glycine cleavage system protein H [Franc...

126

Conserved; Drug target functions

Phase 3: June 2008

1ZKO

40.5%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP00139
(show subtarget assignments)

1

crystallized

No

BA_4355

30258855

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1VKN

40.5%

Bacillus anthracis

Unknown function

General

IDP02108
(show subtarget assignments)

1

in_crystallization_trials

No

STM3680

16766965

aldB

aldehyde dehydrogenase B [Salmonella typ...

512

Conserved; Drug target functions

Phase 3: June 2008

1NZW

40.6%

Salmonella enterica

Energy metabolism

Other

IDP01996
(show subtarget assignments)

1

in_crystallization_trials

No

STM3136

16766436

putative D-mannonate oxidoreductase [Sal...

490

Conserved; Drug target functions

Phase 3: June 2008

1LJ8

40.6%

Salmonella enterica

Energy metabolism

Other

IDP02762
(show subtarget assignments)

1

cloned

No

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01931
(show subtarget assignments)

1

soluble

No

CBU_0073

29540696

peptidase, M24 family protein [Coxiella ...

597

Conserved; Drug target functions

Phase 3: June 2008

3CTZ

40.6%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91728
(show subtarget assignments)

8

selected

No

NP_647593

21536400

BIN1

myc box-dependent-interacting protein 1 ...

593

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2FIC

40.6%

Homo sapiens

IDP02696
(show subtarget assignments)

1

soluble

No

GBAA2773

47528064

acoL

dihydrolipoamide dehydrogenase [Bacillus...

459

Conserved; Drug target functions

Phase 3: June 2008

2QAE

40.6%

Bacillus anthracis

Energy metabolism

Fermentation

IDP91823
(show subtarget assignments)

8

soluble

No

b1854

1788160

pykA

pyruvate kinase II [Escherichia coli str...

480

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

2E28

40.6%

Escherichia coli

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP01306
(show subtarget assignments)

1

purified

No

VC1281

15641294

PTS system, cellobiose-specific IIB comp...

101

Conserved Gene / Pathway

Phase 2: March 2008

2L2Q

40.6%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04042
(show subtarget assignments)

1

cloned

No

CPF_0296

110798725

putative cell division ATP-binding prote...

228

conserved gene; putative drug target function;

Phase 4: April 2009

1F3O

40.6%

Clostridium perfringens

Cellular processes

Cell division

IDP00627
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0552

57285570

hypothetical protein SACOL0552

133

Conserved Gene / Pathway

Phase 2: March 2008

2K4K

40.6%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP91962
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100007760

298255480

amino acid ABC transporter, amino acid-b...

266

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

4EQ9

40.6%

Streptococcus pneumoniae

IDP90192
(show subtarget assignments)

8

cloned

No

AAM13635.1

20153174

CPXV196 CDS

CPXV196 protein

299

serine-threonine kinase

Community Requests

2KTY

40.7%

Cowpox virus

Unknown function

0

IDP02122
(show subtarget assignments)

1

cloned

No

CBU_0090

29540712

tolB

tolB protein [Coxiella burnetii RSA 493]...

437

Conserved; Drug target functions

Phase 3: June 2008

1C5K

40.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP04459
(show subtarget assignments)

1

cloned

No

YPO1472

115347226

conserved hypothetical protein [Yersinia...

782

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

40.7%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP05772
(show subtarget assignments)

1

cloned

No

Z3171

12516188

dacD

penicillin binding protein 6b [Escherich...

425

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZO

40.7%

Escherichia coli

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90753
(show subtarget assignments)

8

crystallized

No

Cj0586

15791946

ligA

NAD-dependent DNA ligase LigA [Campyloba...

647

Predicted Essential

Community Requests

2OWO

40.7%

Campylobacter jejuni

IDP02605
(show subtarget assignments)

1

cloned

No

YPO3502

16123648

hflB

ATP-dependent metalloprotease [Yersinia ...

644

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

2DHR

40.7%

Yersinia pestis

Cellular processes

Cell division

IDP91903
(show subtarget assignments)

8

selected

No

SpneCM_010100005798

298255108

hypothetical protein SpneCM_05798 [Strep...

663

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2DHR

40.7%

Streptococcus pneumoniae

IDP00337
(show subtarget assignments)

1

expressed

No

FTT0946

56708043

trpG

anthranilate synthase component II

184

Drug Target Function

Phase 2: March 2008

1QDL

40.7%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP92103
(show subtarget assignments)

8

selected

No

TGME49_097970

237843837

aspartyl aminopeptidase, putative [Toxop...

506

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3VAR

40.7%

Toxoplasma gondii

IDP04314
(show subtarget assignments)

1

purified

No

YPCD1.73c

5832493

YPCD1.73c

hypothetical protein YPCD1.73c [Yersinia...

149

virulence factor; conserved gene;

Phase 4: April 2009

1JSC

40.7%

Yersinia pestis

IDP01201
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1826

34098434

3-oxoacyl-[acyl-carrier-protein] synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

40.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02401
(show subtarget assignments)

1

cloned

No

Cj0574

15791934

ilvI

acetolactate synthase 3 catalytic subuni...

566

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1JSC

40.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00612
(show subtarget assignments)

1

purified

No

SACOL0582

57285598

nusG

transcription antitermination protein Nu...

182

Drug Target Function

Phase 2: March 2008

2JVV

40.7%

Staphylococcus aureus

Transcription

Transcription factors

IDP02318
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1251

47526517

trpC

indole-3-glycerol-phosphate synthase [Ba...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TSM

40.7%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02826
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4254

47529547

transaminase [Bacillus anthracis str. 'A...

392

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

2O1B

40.8%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP05510
(show subtarget assignments)

1

soluble

No

CD1303

126698901

NAD-dependent deacetylase [Clostridium d...

245

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MA3

40.8%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01757
(show subtarget assignments)

1

purified

No

YPO3509

16123655

obgE

GTPase ObgE [Yersinia pestis CO92]

390

Conserved; CD; Drug target functions

Phase 3: June 2008

1LNZ

40.8%

Yersinia pestis

Unknown function

General

IDP02665
(show subtarget assignments)

1

cloned

No

FTT0469

56707611

ksgA

dimethyladenosine transferase [Francisel...

262

Conserved; Drug target functions

Phase 3: June 2008

3TQS

40.8%

Francisella tularensis

Cellular processesProtein synthesis

Toxin production and resistancetRNA and rRNA base modification

IDP04167
(show subtarget assignments)

1

cloned

No

VC1977

9656518

aspartate aminotransferase, putative [Vi...

404

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XI9

40.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP05579
(show subtarget assignments)

1

soluble

No

BA_0855

30254440

amino acid ABC transporter, amino acid-b...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2YLN

40.8%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04309
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0050

49183085

peptidyl-tRNA hydrolase [Bacillus anthra...

186

Proposed to be essential proteins

Phase 4: April 2009

3KJZ

40.9%

Bacillus anthracis

IDP02822
(show subtarget assignments)

1

cloned

No

GBAA4819

47778330

infC

translation initiation factor IF-3 [Baci...

186

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TIG

40.9%

Bacillus anthracis

Protein synthesis

Translation factors

IDP05425
(show subtarget assignments)

1

soluble

No

lmo0355

16802400

-

fumarate reductase flavoprotein subunit ...

506

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1D4C

40.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP90202
(show subtarget assignments)

8

cloned

No

AAM13655.1

20153194

CPXV217 CDS

CPXV217 protein

372

serine-protease inhibitor (SPI-1)

Community Requests

1F0C

40.9%

Cowpox virus

host defense modulator

0

IDP01010
(show subtarget assignments)

1

purified

No

STM2539

16765859

hscA

chaperone protein HscA

616

Conserved Gene / Pathway

Phase 2: March 2008

2KHO

40.9%

Salmonella enterica

Protein fate

Protein folding and stabilization

IDP04016
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0834

110798754

arsC

arsenate reductase ArsC [Clostridium per...

132

conserved gene; putative drug target function;

Phase 4: April 2009

2L17

40.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP01753
(show subtarget assignments)

1

expressed

No

CBU_0423

29541032

panC

pantoate--beta-alanine ligase [Coxiella ...

257

Conserved; Drug target functions

Phase 3: June 2008

3N8H

40.9%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00768
(show subtarget assignments)

0

work_stopped

No

SACOL0470

57285497

superantigen-like protein

352

Virulence Associated Factor

Phase 2: March 2008

3URY

40.9%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01493
(show subtarget assignments)

1

diffraction

No

VCA0751

161582040

3-oxoacyl-(acyl carrier protein) synthas...

362

Drug Target Function

Phase 2: March 2008

2EBD

40.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90854
(show subtarget assignments)

8

crystallized

No

Cj1727c

15793030

metY

putative O-acetylhomoserine (thiol)-lyas...

423

Predicted Essential

Community Requests

2CTZ

40.9%

Campylobacter jejuni

IDP01396
(show subtarget assignments)

1

purified

No

VC0752

15640771

hscA

chaperone protein HscA

616

Conserved Gene / Pathway

Phase 2: March 2008

2KHO

40.9%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP91016
(show subtarget assignments)

8

selected

No

y2451

22126334

hypothetical protein y2451 [Yersinia pes...

384

other biological interest / putative iron transport protein

Community Requests

3AT7

40.9%

Yersinia pestis

IDP02370
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1958

47527254

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

242

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3OEC

40.9%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02141
(show subtarget assignments)

1

purified

No

CBU_0737

29541337

tig

trigger factor [Coxiella burnetii RSA 49...

442

Conserved; Drug target functions

Phase 3: June 2008

1W26

41%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP00257
(show subtarget assignments)

1

in_crystallization_trials

No

MODVgp1

20177456

Modoc virus Envelope protein

393

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1SVB

41%

Modoc virus

IDP01852
(show subtarget assignments)

1

cloned

No

GBAA5449

47530763

celA-3

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02705
(show subtarget assignments)

1

cloned

No

lmo0202

16802248

hly

listeriolysin O precursor [Listeria mono...

529

Known virulence-Toxin; Predicted virulence-Pathogenicity islands; PMID:11901162

Phase 3: June 2008

3HVN

41%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP00719
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1457

57284566

PTS system, IIA component

166

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

41%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05512
(show subtarget assignments)

1

cloned

No

CD1601

126699205

thiE1

thiamine-phosphate pyrophosphorylase [Cl...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XI3

41%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00620
(show subtarget assignments)

1

cloned

No

SACOL0937

57285812

dltC

D-alanine--poly(phosphoribitol) ligase s...

78

Conserved Gene / Pathway

Phase 2: March 2008

1DV5

41%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05547
(show subtarget assignments)

1

soluble

No

lmo0285

16802331

-

putative lipoprotein [Listeria monocytog...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQW

41%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP02234
(show subtarget assignments)

1

cloned

No

FTT1094c

56708177

cytosol aminopeptidase family protein [F...

471

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IJ3

41.1%

Francisella tularensis

N/A

IDP04407
(show subtarget assignments)

1

cloned

No

CPF_0677

110799553

purH

bifunctional phosphoribosylaminoimidazol...

501

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

41.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01847
(show subtarget assignments)

1

soluble

No

GBAA5416

47530729

ftsE

cell division ABC transporter, ATP-bindi...

214

Conserved; Drug target functions

Phase 3: June 2008

3DHW

41.1%

Bacillus anthracis

Cellular processes

Cell division

IDP90005
(show subtarget assignments)

8

soluble

No

Z4377

12517595

qseB

quorum sensing Escherichia coli regulato...

219

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3Q9S

41.1%

Escherichia coli

IDP91359
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_2847

27366129

response regulator [Vibrio vulnificus CM...

219

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1KGS

41.1%

Vibrio vulnificus

IDP92087
(show subtarget assignments)

8

selected

No

TGME49_116330

237831005

iron-containing superoxide dismutase [To...

287

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2AWP

41.1%

Toxoplasma gondii

IDP02323
(show subtarget assignments)

1

soluble

No

FTT0560c

56707690

serC

phosphoserine aminotransferase [Francise...

350

Drug Target

Phase 3: June 2008

3QBO

41.1%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism

Aspartate familyOther