Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04153 (show subtarget assignments)	1	cloned	No	YPO3975	218930970	opdA	oligopeptidase A [Yersinia pestis CO92]	680	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1S4B	30.7%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91024 (show subtarget assignments)	8	cloned	No	y2983	22126860		outer membrane protein C2 [Yersinia pest...	371	drug resistance / anion-specific outer membrane porin	Community Requests	3HW9	59.9%	Yersinia pestis

IDP04152 (show subtarget assignments)	1	cloned	No	YPO3919	218930919		HlyD family secretion protein [Yersinia ...	442	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05391 (show subtarget assignments)	1	cloned	No	BA_2630	30257247		conserved hypothetical protein [Bacillus...	51	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP04151 (show subtarget assignments)	1	cloned	No	YPO3864	218930867	nfrC	UDP-N-acetylglucosamine 2-epimerase [Yer...	376	drug target; putative drug target function;	Phase 4: April 2009	1F6D	78.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04583 (show subtarget assignments)	1	cloned	No	BAS0111	49183145		50S ribosomal protein L4 [Bacillus anthr...	207	Proposed to be essential proteins	Phase 4: April 2009	1DMG	47.1%	Bacillus anthracis

IDP05582 (show subtarget assignments)	1	cloned	No	BA_1978	30256633		putative lipoprotein [Bacillus anthracis...	218	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05395 (show subtarget assignments)	1	cloned	No	BA_2942	30257534		putative lipoprotein [Bacillus anthracis...	86	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP90775 (show subtarget assignments)	8	cloned	No	YPO0345	16120680	dipZ	thiol:disulfide interchange protein prec...	595	Predicted Essential	Community Requests	1UC7	12.8%	Yersinia pestis

IDP02439 (show subtarget assignments)	1	cloned	No	GBAA3892	47529180		serine protease [Bacillus anthracis str....	613	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2OXA	16.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02440 (show subtarget assignments)	1	cloned	No	lmo0331	16802376		hypothetical protein lmo0331 [Listeria m...	633	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	3BZ5	28.4%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP04010 (show subtarget assignments)	1	cloned	No	CPF_2393	110798628	minD	septum site-determining protein MinD [Cl...	265	conserved gene; putative drug target function;	Phase 4: April 2009	3Q9L	43.4%	Clostridium perfringens	Cellular processes	Cell division

IDP91038 (show subtarget assignments)	8	cloned	No	SAHV_2481	156980811		hypothetical protein SAHV_2481 [Staphylo...	1115	drug resistance / SasG is a highly interesting multi-domain protein involved in biofilm formation ...	Community Requests	3TIQ	18.7%	Staphylococcus aureus

IDP90860 (show subtarget assignments)	8	cloned	No	YPO1057	16121357	lpxB	lipid-A-disaccharide synthase [Yersinia ...	394	Predicted Essential	Community Requests			Yersinia pestis

IDP02444 (show subtarget assignments)	1	cloned	No	YPO2224	16122453		hypothetical protein YPO2224 [Yersinia p...	103	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP00635 (show subtarget assignments)	1	cloned	No	SACOL2270	57286396	modC	molybdenum ABC transporter, ATP-binding ...	201	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	38.8%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP04161 (show subtarget assignments)	1	cloned	No	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04159 (show subtarget assignments)	1	cloned	No	VC1134	15641147		histidinol-phosphate aminotransferase [V...	346	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FG3	59.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP00636 (show subtarget assignments)	1	cloned	No	SACOL1118	57285904	typA	GTP-binding protein TypA	615	Drug Target Function	Phase 2: March 2008	3E3X	27.6%	Staphylococcus aureus	Unknown function	General

IDP02534 (show subtarget assignments)	1	cloned	No	GBAA4614	47529912		Holliday junction resolvase-like protein...	137	Conserved;	Phase 3: June 2008	1VHX	70.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP91068 (show subtarget assignments)	8	cloned	No	VF_A0424	59713607	msbA	lipid transporter ATP-binding/permease p...	582	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5X	75.1%	Vibrio fischeri

IDP91069 (show subtarget assignments)	8	cloned	No	SP_1357	15901211		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	37.1%	Streptococcus pneumoniae

IDP00637 (show subtarget assignments)	1	cloned	No	SACOL1727	57284738	infC	translation initiation factor IF-3	175	Drug Target Function	Phase 2: March 2008	1TIG	37.7%	Staphylococcus aureus	Protein synthesis	Translation factors

IDP02651 (show subtarget assignments)	1	cloned	No	GBAA1287	47526553	sipW	signal peptidase I [Bacillus anthracis s...	189	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP04170 (show subtarget assignments)	1	cloned	No	VC2183	15642182		ribose-phosphate pyrophosphokinase [Vibr...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3DAH	63.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04171 (show subtarget assignments)	1	cloned	No	VC2244	15642242		acetyl-CoA carboxylase carboxyltransfera...	319	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP05400 (show subtarget assignments)	1	cloned	No	BA_0243	30253741		hypothetical protein BA_0243 [Bacillus a...	36	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP91076 (show subtarget assignments)	8	cloned	No	CGSHiII_09046	145639651		fused lipid transporter subunits of ABC ...	587	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5W	65.9%	Haemophilus influenzae

IDP04591 (show subtarget assignments)	1	cloned	No	BAS0138	49183172		50S ribosomal protein L17 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1NKW	50.8%	Bacillus anthracis

IDP91078 (show subtarget assignments)	8	cloned	No	CBU_0856	29541449		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5X	42.3%	Coxiella burnetii

IDP02460 (show subtarget assignments)	1	cloned	No	YPO1675	16121939	cheD	methyl-accepting chemotaxis protein [Yer...	557	CD; Drug target functions	Phase 3: June 2008	3ZX6	43.3%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02461 (show subtarget assignments)	1	cloned	No	Cj0176c	15791563		putative lipoprotein [Campylobacter jeju...	43	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Cations and iron carrying compounds

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04008 (show subtarget assignments)	1	cloned	No	YPO0906	218928079	gcsH	glycine cleavage system protein H [Yersi...	128	conserved gene; putative drug target function;	Phase 4: April 2009	3A7A	75%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02464 (show subtarget assignments)	1	cloned	No	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP00317 (show subtarget assignments)	1	cloned	No	CBU_1887	29655172	ponA	penicillin-binding protein 1A	793	Drug Target Function	Phase 2: March 2008	3UDF	40.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04593 (show subtarget assignments)	1	cloned	No	BAS0144	49183178		30S ribosomal protein S9 [Bacillus anthr...	130	Proposed to be essential proteins	Phase 4: April 2009	1VS5	55.4%	Bacillus anthracis

IDP04166 (show subtarget assignments)	1	cloned	No	VC1653	15641658		sensory box sensor histidine kinase/resp...	1146	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	6.6%	Vibrio cholerae	Regulatory functions	Other

IDP02468 (show subtarget assignments)	1	cloned	No	Cj0914c	15792243		invasion antigen B [Campylobacter jejuni...	610	Known Predicted virulence-invasion; PMID:10339609	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP02469 (show subtarget assignments)	1	cloned	No	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04179 (show subtarget assignments)	1	cloned	No	VCA0068	15600839		methyl-accepting chemotaxis protein [Vib...	547	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3ZX6	18.3%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP02471 (show subtarget assignments)	1	cloned	No	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP04611 (show subtarget assignments)	1	cloned	No	BAS3754	49186753		sporulation sigma factor SigG [Bacillus ...	289	Proposed to be essential proteins	Phase 4: April 2009	1L0O	37%	Bacillus anthracis

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP02474 (show subtarget assignments)	1	cloned	No	Cj0922c	15792251	pebC	amino acid ABC transporter ATP-binding p...	242	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	2OLJ	52.5%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02475 (show subtarget assignments)	1	cloned	No	GBAA3660	47528945		serine protease [Bacillus anthracis str....	413	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZLE	30%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02476 (show subtarget assignments)	1	cloned	No	YPO1776	16122030	dbpA	ATP-dependent RNA helicase DbpA [Yersini...	460	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2I4I	30%	Yersinia pestis	Transcription	Transcription factors

IDP02477 (show subtarget assignments)	1	cloned	No	YPO2035	16122274		hypothetical protein YPO2035 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1ZCC	23.6%	Yersinia pestis	Central intermediary metabolism	Other

IDP02478 (show subtarget assignments)	1	cloned	No	GBAA4182	47529478	pdhC	branched-chain alpha-keto acid dehydroge...	419	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	74.7%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP02479 (show subtarget assignments)	1	cloned	No	lmo1287	16803327	parC	DNA topoisomerase IV subunit A [Listeria...	819	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2INR	41.8%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP02480 (show subtarget assignments)	1	cloned	No	GBAA5700	47531036	galE-2	UDP-glucose 4-epimerase [Bacillus anthra...	338	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3ENK	58.6%	Bacillus anthracis	Energy metabolism	Sugars

IDP02481 (show subtarget assignments)	1	cloned	No	Cj1139c	15792464		putative galactosyltransferase [Campylob...	303	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3BCV	24.1%	Campylobacter jejuni	DNA metabolism	DNA replication, recombination, and repair

IDP04600 (show subtarget assignments)	1	cloned	No	BAS2547	49185555		preprotein translocase subunit SecY [Bac...	434	Proposed to be essential proteins	Phase 4: April 2009	3DIN	42.2%	Bacillus anthracis

IDP02483 (show subtarget assignments)	1	cloned	No	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP90992 (show subtarget assignments)	8	cloned	No	y1333	22125232		DNA-binding transcriptional regulator Is...	185	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	3T8R	25.4%	Yersinia pestis

IDP02485 (show subtarget assignments)	1	cloned	No	FTT1539c	56708571		hypothetical protein FTT1539c [Francisel...	476	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP05428 (show subtarget assignments)	1	cloned	No	lmo0717	16802759	-	hypothetical protein lmo0717 [Listeria m...	222	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Viral functions: General

IDP02487 (show subtarget assignments)	1	cloned	No	GBAA4218	47529511	metE	5-methyltetrahydropteroyltriglutamate--h...	762	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2NQ5	51.3%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP91278 (show subtarget assignments)	8	cloned	No	NT05BA4419	49181159		RNA polymerase sigma-27 factor [Bacillus...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L9U	30.8%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP91515 (show subtarget assignments)	8	cloned	No	VV2_1587	27367932	malG	maltose transporter permease [Vibrio vul...	296	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2R6G	82.4%	Vibrio vulnificus

IDP91194 (show subtarget assignments)	8	cloned	No	BAS4090	49187088	-	Stage III sporulation protein AH	223	essential/virulence/pathogenesis / Essential proteins	Community Requests	3TUF	32.7%	Bacillus anthracis

IDP02491 (show subtarget assignments)	1	cloned	No	YPO1811	16122063		short chain dehydrogenase [Yersinia pest...	688	Conserved; CD; Drug target functions	Phase 3: June 2008	3U0B	14.8%	Yersinia pestis	Central intermediary metabolism	Other

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00648 (show subtarget assignments)	1	cloned	No	SACOL2160	57286373		hemolysin III, putative	227	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02494 (show subtarget assignments)	1	cloned	No	GBAA0550	47525823		hypothetical protein GBAA0550 [Bacillus ...	631	Drug target motif; Conserved;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP02495 (show subtarget assignments)	1	cloned	No	Cj1565c	15792870	pflA	paralyzed flagella protein PflA [Campylo...	788	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Unclassified	Unclassified

IDP05431 (show subtarget assignments)	1	cloned	No	lmo1224	16803264	-	hypothetical protein lmo1224 [Listeria m...	1136	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP02497 (show subtarget assignments)	1	cloned	No	FTT1287	56708346	cbs	cystathionine beta-synthase (cystein syn...	307	Conserved; Drug target functions	Phase 3: June 2008	4AEC	33.2%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP02498 (show subtarget assignments)	1	cloned	No	FTT1556c	56708584	lepB	signal peptidase I [Francisella tularens...	287	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1B12	33.4%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP02540 (show subtarget assignments)	1	cloned	No	CBU_1584	29542144	shaE	monovalent cation/proton antiporter subu...	115	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP01243 (show subtarget assignments)	1	cloned	No	BA_2345	30256982		penicillin-binding protein 1A	820	Drug Target Function	Phase 2: March 2008	2OLU	29.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02501 (show subtarget assignments)	1	cloned	No	GBAA1250	47526516	trpD	anthranilate phosphoribosyltransferase [...	341	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VQU	39.6%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02503 (show subtarget assignments)	1	cloned	No	YPO2502	16122723	gutB	putative zinc-binding dehydrogenase [Yer...	408	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	2D8A	30.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Chlorophyll and bacteriochlorphyll

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02539 (show subtarget assignments)	1	cloned	No	YPO3200	16123361	malZ	maltodextrin glucosidase [Yersinia pesti...	609	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EA9	33.5%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP90676 (show subtarget assignments)	8	expressed	No	Cj0533	15791894	sucC	succinyl-CoA synthase, beta subunit [Cam...	387	Predicted Essential	Community Requests	1CQI	45.5%	Campylobacter jejuni

IDP02273 (show subtarget assignments)	1	expressed	No	GBAA3714	47528998		hypothetical protein GBAA3714 [Bacillus ...	315	Conserved; Essential;	Phase 3: June 2008	3CCF	14.3%	Bacillus anthracis	Hypothetical proteins	Domain

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP02268 (show subtarget assignments)	1	expressed	No	FTT1133	56708209	pilB	Type IV pili nucleotide binding protein,...	592	Conserved; Drug target functions	Phase 3: June 2008	1P9R	31.1%	Francisella tularensis	Cell envelope	Surface structures

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02261 (show subtarget assignments)	1	expressed	No	GBAA2516	47527804	fba-1	fructose-bisphosphate aldolase [Bacillus...	281	Essential; Drug target functions	Phase 3: June 2008	1RV8	41.2%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP04078 (show subtarget assignments)	1	expressed	No	YPCD1.09c	5832432	YPCD1.09c	hypothetical protein YPCD1.09c [Yersinia...	91	virulence factor; conserved gene;	Phase 4: April 2009	3KXE	29.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00585 (show subtarget assignments)	1	expressed	No	YPO0116	16120461	metL	bifunctional aspartate kinase II/homoser...	811	Virulence Associated Factor	Phase 2: March 2008	1EBF	15.5%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02257 (show subtarget assignments)	1	expressed	No	CBU_2074	29542624	hemC	porphobilinogen deaminase [Coxiella burn...	307	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP05288 (show subtarget assignments)	1	expressed	No	CD0252	126697823	fliJ	flagellar protein [Clostridium difficile...	148	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90673 (show subtarget assignments)	8	expressed	No	VC1833	15641835		quinolinate synthetase [Vibrio cholerae ...	353	Predicted Essential	Community Requests	1WZU	30.6%	Vibrio cholerae

IDP02249 (show subtarget assignments)	1	expressed	No	YPO0955	16121258		hypothetical protein YPO0955 [Yersinia p...	323	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2R79	22%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00583 (show subtarget assignments)	1	expressed	No	YPO2752	16122956	mepA	penicillin-insensitive murein endopeptid...	275	Drug Target Function	Phase 2: March 2008	1TZP	67.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90654 (show subtarget assignments)	8	expressed	No	YPO0474	16120803	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Predicted Essential	Community Requests	1MRZ	32.1%	Yersinia pestis

IDP02247 (show subtarget assignments)	1	expressed	No	FTT0665c	56707786		aldolase/adducin class II family protein...	201	Drug Target	Phase 3: June 2008	3OCR	32.3%	Francisella tularensis	Unknown function	General

IDP02246 (show subtarget assignments)	1	expressed	No	FTT0649c	56707771	rnfB	Iron-sulfur cluster-binding protein [Fra...	209	Drug Target	Phase 3: June 2008	1GT8	12.9%	Francisella tularensis	Energy metabolism	Electron transport

IDP01116 (show subtarget assignments)	1	expressed	No	BA_1693	30255984		glycosyl transferase, group 2 family pro...	150	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04515 (show subtarget assignments)	1	expressed	No	CPF_2673	110799735		putative sensor histidine kinase [Clostr...	583	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP90655 (show subtarget assignments)	8	expressed	No	Cj1346c	15792669	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	356	Predicted Essential	Community Requests	1R0K	36.2%	Campylobacter jejuni

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02239 (show subtarget assignments)	1	expressed	No	GBAA0299	47525562	purD	phosphoribosylamine--glycine ligase [Bac...	423	Conserved; Drug target functions	Phase 3: June 2008	2YRW	64.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02238 (show subtarget assignments)	1	expressed	No	YPO0815	16121126		general secretion pathway protein E [Yer...	503	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	48.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04153
(show subtarget assignments)

1

cloned

No

YPO3975

218930970

opdA

oligopeptidase A [Yersinia pestis CO92]

680

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1S4B

30.7%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91024
(show subtarget assignments)

8

cloned

No

y2983

22126860

outer membrane protein C2 [Yersinia pest...

371

drug resistance / anion-specific outer membrane porin

Community Requests

3HW9

59.9%

Yersinia pestis

IDP04152
(show subtarget assignments)

1

cloned

No

YPO3919

218930919

HlyD family secretion protein [Yersinia ...

442

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05391
(show subtarget assignments)

1

cloned

No

BA_2630

30257247

conserved hypothetical protein [Bacillus...

51

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP04151
(show subtarget assignments)

1

cloned

No

YPO3864

218930867

nfrC

UDP-N-acetylglucosamine 2-epimerase [Yer...

376

drug target; putative drug target function;

Phase 4: April 2009

1F6D

78.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04583
(show subtarget assignments)

1

cloned

No

BAS0111

49183145

50S ribosomal protein L4 [Bacillus anthr...

207

Proposed to be essential proteins

Phase 4: April 2009

1DMG

47.1%

Bacillus anthracis

IDP05582
(show subtarget assignments)

1

cloned

No

BA_1978

30256633

putative lipoprotein [Bacillus anthracis...

218

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05395
(show subtarget assignments)

1

cloned

No

BA_2942

30257534

putative lipoprotein [Bacillus anthracis...

86

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP90775
(show subtarget assignments)

8

cloned

No

YPO0345

16120680

dipZ

thiol:disulfide interchange protein prec...

595

Predicted Essential

Community Requests

1UC7

12.8%

Yersinia pestis

IDP02439
(show subtarget assignments)

1

cloned

No

GBAA3892

47529180

serine protease [Bacillus anthracis str....

613

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2OXA

16.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02440
(show subtarget assignments)

1

cloned

No

lmo0331

16802376

hypothetical protein lmo0331 [Listeria m...

633

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

3BZ5

28.4%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP04010
(show subtarget assignments)

1

cloned

No

CPF_2393

110798628

minD

septum site-determining protein MinD [Cl...

265

conserved gene; putative drug target function;

Phase 4: April 2009

3Q9L

43.4%

Clostridium perfringens

Cellular processes

Cell division

IDP91038
(show subtarget assignments)

8

cloned

No

SAHV_2481

156980811

hypothetical protein SAHV_2481 [Staphylo...

1115

drug resistance / SasG is a highly interesting multi-domain protein involved in biofilm formation ...

Community Requests

3TIQ

18.7%

Staphylococcus aureus

IDP90860
(show subtarget assignments)

8

cloned

No

YPO1057

16121357

lpxB

lipid-A-disaccharide synthase [Yersinia ...

394

Predicted Essential

Community Requests

Yersinia pestis

IDP02444
(show subtarget assignments)

1

cloned

No

YPO2224

16122453

hypothetical protein YPO2224 [Yersinia p...

103

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP00635
(show subtarget assignments)

1

cloned

No

SACOL2270

57286396

modC

molybdenum ABC transporter, ATP-binding ...

201

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

38.8%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP04161
(show subtarget assignments)

1

cloned

No

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04159
(show subtarget assignments)

1

cloned

No

VC1134

15641147

histidinol-phosphate aminotransferase [V...

346

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FG3

59.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP00636
(show subtarget assignments)

1

cloned

No

SACOL1118

57285904

typA

GTP-binding protein TypA

615

Drug Target Function

Phase 2: March 2008

3E3X

27.6%

Staphylococcus aureus

Unknown function

General

IDP02534
(show subtarget assignments)

1

cloned

No

GBAA4614

47529912

Holliday junction resolvase-like protein...

137

Conserved;

Phase 3: June 2008

1VHX

70.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP91068
(show subtarget assignments)

8

cloned

No

VF_A0424

59713607

msbA

lipid transporter ATP-binding/permease p...

582

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5X

75.1%

Vibrio fischeri

IDP91069
(show subtarget assignments)

8

cloned

No

SP_1357

15901211

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

37.1%

Streptococcus pneumoniae

IDP00637
(show subtarget assignments)

1

cloned

No

SACOL1727

57284738

infC

translation initiation factor IF-3

175

Drug Target Function

Phase 2: March 2008

1TIG

37.7%

Staphylococcus aureus

Protein synthesis

Translation factors

IDP02651
(show subtarget assignments)

1

cloned

No

GBAA1287

47526553

sipW

signal peptidase I [Bacillus anthracis s...

189

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP04170
(show subtarget assignments)

1

cloned

No

VC2183

15642182

ribose-phosphate pyrophosphokinase [Vibr...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3DAH

63.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04171
(show subtarget assignments)

1

cloned

No

VC2244

15642242

acetyl-CoA carboxylase carboxyltransfera...

319

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP05400
(show subtarget assignments)

1

cloned

No

BA_0243

30253741

hypothetical protein BA_0243 [Bacillus a...

36

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP91076
(show subtarget assignments)

8

cloned

No

CGSHiII_09046

145639651

fused lipid transporter subunits of ABC ...

587

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5W

65.9%

Haemophilus influenzae

IDP04591
(show subtarget assignments)

1

cloned

No

BAS0138

49183172

50S ribosomal protein L17 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1NKW

50.8%

Bacillus anthracis

IDP91078
(show subtarget assignments)

8

cloned

No

CBU_0856

29541449

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5X

42.3%

Coxiella burnetii

IDP02460
(show subtarget assignments)

1

cloned

No

YPO1675

16121939

cheD

methyl-accepting chemotaxis protein [Yer...

557

CD; Drug target functions

Phase 3: June 2008

3ZX6

43.3%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02461
(show subtarget assignments)

1

cloned

No

Cj0176c

15791563

putative lipoprotein [Campylobacter jeju...

43

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Cations and iron carrying compounds

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04008
(show subtarget assignments)

1

cloned

No

YPO0906

218928079

gcsH

glycine cleavage system protein H [Yersi...

128

conserved gene; putative drug target function;

Phase 4: April 2009

3A7A

75%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02464
(show subtarget assignments)

1

cloned

No

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP00317
(show subtarget assignments)

1

cloned

No

CBU_1887

29655172

ponA

penicillin-binding protein 1A

793

Drug Target Function

Phase 2: March 2008

3UDF

40.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04593
(show subtarget assignments)

1

cloned

No

BAS0144

49183178

30S ribosomal protein S9 [Bacillus anthr...

130

Proposed to be essential proteins

Phase 4: April 2009

1VS5

55.4%

Bacillus anthracis

IDP04166
(show subtarget assignments)

1

cloned

No

VC1653

15641658

sensory box sensor histidine kinase/resp...

1146

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

6.6%

Vibrio cholerae

Regulatory functions

Other

IDP02468
(show subtarget assignments)

1

cloned

No

Cj0914c

15792243

invasion antigen B [Campylobacter jejuni...

610

Known Predicted virulence-invasion; PMID:10339609

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP02469
(show subtarget assignments)

1

cloned

No

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04179
(show subtarget assignments)

1

cloned

No

VCA0068

15600839

methyl-accepting chemotaxis protein [Vib...

547

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3ZX6

18.3%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP02471
(show subtarget assignments)

1

cloned

No

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP04611
(show subtarget assignments)

1

cloned

No

BAS3754

49186753

sporulation sigma factor SigG [Bacillus ...

289

Proposed to be essential proteins

Phase 4: April 2009

1L0O

37%

Bacillus anthracis

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP02474
(show subtarget assignments)

1

cloned

No

Cj0922c

15792251

pebC

amino acid ABC transporter ATP-binding p...

242

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

2OLJ

52.5%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02475
(show subtarget assignments)

1

cloned

No

GBAA3660

47528945

serine protease [Bacillus anthracis str....

413

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZLE

30%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02476
(show subtarget assignments)

1

cloned

No

YPO1776

16122030

dbpA

ATP-dependent RNA helicase DbpA [Yersini...

460

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2I4I

30%

Yersinia pestis

Transcription

Transcription factors

IDP02477
(show subtarget assignments)

1

cloned

No

YPO2035

16122274

hypothetical protein YPO2035 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1ZCC

23.6%

Yersinia pestis

Central intermediary metabolism

Other

IDP02478
(show subtarget assignments)

1

cloned

No

GBAA4182

47529478

pdhC

branched-chain alpha-keto acid dehydroge...

419

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

74.7%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP02479
(show subtarget assignments)

1

cloned

No

lmo1287

16803327

parC

DNA topoisomerase IV subunit A [Listeria...

819

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2INR

41.8%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP02480
(show subtarget assignments)

1

cloned

No

GBAA5700

47531036

galE-2

UDP-glucose 4-epimerase [Bacillus anthra...

338

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3ENK

58.6%

Bacillus anthracis

Energy metabolism

Sugars

IDP02481
(show subtarget assignments)

1

cloned

No

Cj1139c

15792464

putative galactosyltransferase [Campylob...

303

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3BCV

24.1%

Campylobacter jejuni

DNA metabolism

DNA replication, recombination, and repair

IDP04600
(show subtarget assignments)

1

cloned

No

BAS2547

49185555

preprotein translocase subunit SecY [Bac...

434

Proposed to be essential proteins

Phase 4: April 2009

3DIN

42.2%

Bacillus anthracis

IDP02483
(show subtarget assignments)

1

cloned

No

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP90992
(show subtarget assignments)

8

cloned

No

y1333

22125232

DNA-binding transcriptional regulator Is...

185

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

3T8R

25.4%

Yersinia pestis

IDP02485
(show subtarget assignments)

1

cloned

No

FTT1539c

56708571

hypothetical protein FTT1539c [Francisel...

476

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP05428
(show subtarget assignments)

1

cloned

No

lmo0717

16802759

-

hypothetical protein lmo0717 [Listeria m...

222

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Viral functions: General

IDP02487
(show subtarget assignments)

1

cloned

No

GBAA4218

47529511

metE

5-methyltetrahydropteroyltriglutamate--h...

762

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2NQ5

51.3%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP91278
(show subtarget assignments)

8

cloned

No

NT05BA4419

49181159

RNA polymerase sigma-27 factor [Bacillus...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L9U

30.8%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP91515
(show subtarget assignments)

8

cloned

No

VV2_1587

27367932

malG

maltose transporter permease [Vibrio vul...

296

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2R6G

82.4%

Vibrio vulnificus

IDP91194
(show subtarget assignments)

8

cloned

No

BAS4090

49187088

-

Stage III sporulation protein AH

223

essential/virulence/pathogenesis / Essential proteins

Community Requests

3TUF

32.7%

Bacillus anthracis

IDP02491
(show subtarget assignments)

1

cloned

No

YPO1811

16122063

short chain dehydrogenase [Yersinia pest...

688

Conserved; CD; Drug target functions

Phase 3: June 2008

3U0B

14.8%

Yersinia pestis

Central intermediary metabolism

Other

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00648
(show subtarget assignments)

1

cloned

No

SACOL2160

57286373

hemolysin III, putative

227

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02494
(show subtarget assignments)

1

cloned

No

GBAA0550

47525823

hypothetical protein GBAA0550 [Bacillus ...

631

Drug target motif; Conserved;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02495
(show subtarget assignments)

1

cloned

No

Cj1565c

15792870

pflA

paralyzed flagella protein PflA [Campylo...

788

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Unclassified

IDP05431
(show subtarget assignments)

1

cloned

No

lmo1224

16803264

-

hypothetical protein lmo1224 [Listeria m...

1136

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP02497
(show subtarget assignments)

1

cloned

No

FTT1287

56708346

cbs

cystathionine beta-synthase (cystein syn...

307

Conserved; Drug target functions

Phase 3: June 2008

4AEC

33.2%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP02498
(show subtarget assignments)

1

cloned

No

FTT1556c

56708584

lepB

signal peptidase I [Francisella tularens...

287

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1B12

33.4%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP02540
(show subtarget assignments)

1

cloned

No

CBU_1584

29542144

shaE

monovalent cation/proton antiporter subu...

115

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP01243
(show subtarget assignments)

1

cloned

No

BA_2345

30256982

penicillin-binding protein 1A

820

Drug Target Function

Phase 2: March 2008

2OLU

29.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02501
(show subtarget assignments)

1

cloned

No

GBAA1250

47526516

trpD

anthranilate phosphoribosyltransferase [...

341

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VQU

39.6%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02503
(show subtarget assignments)

1

cloned

No

YPO2502

16122723

gutB

putative zinc-binding dehydrogenase [Yer...

408

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

2D8A

30.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Chlorophyll and bacteriochlorphyll

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02539
(show subtarget assignments)

1

cloned

No

YPO3200

16123361

malZ

maltodextrin glucosidase [Yersinia pesti...

609

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EA9

33.5%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP90676
(show subtarget assignments)

8

expressed

No

Cj0533

15791894

sucC

succinyl-CoA synthase, beta subunit [Cam...

387

Predicted Essential

Community Requests

1CQI

45.5%

Campylobacter jejuni

IDP02273
(show subtarget assignments)

1

expressed

No

GBAA3714

47528998

hypothetical protein GBAA3714 [Bacillus ...

315

Conserved; Essential;

Phase 3: June 2008

3CCF

14.3%

Bacillus anthracis

Hypothetical proteins

Domain

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP02268
(show subtarget assignments)

1

expressed

No

FTT1133

56708209

pilB

Type IV pili nucleotide binding protein,...

592

Conserved; Drug target functions

Phase 3: June 2008

1P9R

31.1%

Francisella tularensis

Cell envelope

Surface structures

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02261
(show subtarget assignments)

1

expressed

No

GBAA2516

47527804

fba-1

fructose-bisphosphate aldolase [Bacillus...

281

Essential; Drug target functions

Phase 3: June 2008

1RV8

41.2%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP04078
(show subtarget assignments)

1

expressed

No

YPCD1.09c

5832432

YPCD1.09c

hypothetical protein YPCD1.09c [Yersinia...

91

virulence factor; conserved gene;

Phase 4: April 2009

3KXE

29.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00585
(show subtarget assignments)

1

expressed

No

YPO0116

16120461

metL

bifunctional aspartate kinase II/homoser...

811

Virulence Associated Factor

Phase 2: March 2008

1EBF

15.5%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02257
(show subtarget assignments)

1

expressed

No

CBU_2074

29542624

hemC

porphobilinogen deaminase [Coxiella burn...

307

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP05288
(show subtarget assignments)

1

expressed

No

CD0252

126697823

fliJ

flagellar protein [Clostridium difficile...

148

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90673
(show subtarget assignments)

8

expressed

No

VC1833

15641835

quinolinate synthetase [Vibrio cholerae ...

353

Predicted Essential

Community Requests

1WZU

30.6%

Vibrio cholerae

IDP02249
(show subtarget assignments)

1

expressed

No

YPO0955

16121258

hypothetical protein YPO0955 [Yersinia p...

323

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2R79

22%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00583
(show subtarget assignments)

1

expressed

No

YPO2752

16122956

mepA

penicillin-insensitive murein endopeptid...

275

Drug Target Function

Phase 2: March 2008

1TZP

67.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90654
(show subtarget assignments)

8

expressed

No

YPO0474

16120803

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Predicted Essential

Community Requests

1MRZ

32.1%

Yersinia pestis

IDP02247
(show subtarget assignments)

1

expressed

No

FTT0665c

56707786

aldolase/adducin class II family protein...

201

Drug Target

Phase 3: June 2008

3OCR

32.3%

Francisella tularensis

Unknown function

General

IDP02246
(show subtarget assignments)

1

expressed

No

FTT0649c

56707771

rnfB

Iron-sulfur cluster-binding protein [Fra...

209

Drug Target

Phase 3: June 2008

1GT8

12.9%

Francisella tularensis

Energy metabolism

Electron transport

IDP01116
(show subtarget assignments)

1

expressed

No

BA_1693

30255984

glycosyl transferase, group 2 family pro...

150

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04515
(show subtarget assignments)

1

expressed

No

CPF_2673

110799735

putative sensor histidine kinase [Clostr...

583

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP90655
(show subtarget assignments)

8

expressed

No

Cj1346c

15792669

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

356

Predicted Essential

Community Requests

1R0K

36.2%

Campylobacter jejuni

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02239
(show subtarget assignments)

1

expressed

No

GBAA0299

47525562

purD

phosphoribosylamine--glycine ligase [Bac...

423

Conserved; Drug target functions

Phase 3: June 2008

2YRW

64.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02238
(show subtarget assignments)

1

expressed

No

YPO0815

16121126

general secretion pathway protein E [Yer...

503

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

48.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking