Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02430 (show subtarget assignments)	1	expressed	No	FTT1151c	56708222		hypothetical protein FTT1151c [Francisel...	95	Drug Target	Phase 3: June 2008	2JR5	25.3%	Francisella tularensis	Unknown function	General

IDP02431 (show subtarget assignments)	1	crystallized	No	CBU_1770	29542327		ABC transporter, ATP-binding protein [Co...	432	Conserved; Drug target functions	Phase 3: June 2008	2YYZ	23.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02432 (show subtarget assignments)	1	soluble	No	GBAA3687	47528971		acetyl-CoA acetyltransferase [Bacillus a...	363	Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...	Phase 3: June 2008	4DD5	39.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP01209 (show subtarget assignments)	1	soluble	No	BA_2650	30257267		penicillin-binding protein	340	Drug Target Function	Phase 2: March 2008	3TG9	53.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01210 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2805	30257409		glycosyl hydrolase, family 25, putative ...	268	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	61.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05095 (show subtarget assignments)	1	soluble	No	BA_5481	30259944		conserved domain protein [Bacillus anthr...	290	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP02436 (show subtarget assignments)	1	cloned	No	Cj1418c	15792736		hypothetical protein Cj1418c [Campylobac...	779	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Energy metabolism	Electron transport

IDP01211 (show subtarget assignments)	1	crystallized	No	BA_2958	30257549		chorismate mutase/phospho-2-dehydro-3-de...	358	Drug Target Function	Phase 2: March 2008	3NVT	69.8%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02438 (show subtarget assignments)	1	cloned	No	CBU_0029	29540654		acyltransferase family protein [Coxiella...	242	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP02439 (show subtarget assignments)	1	cloned	No	GBAA3892	47529180		serine protease [Bacillus anthracis str....	613	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2OXA	16.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02440 (show subtarget assignments)	1	cloned	No	lmo0331	16802376		hypothetical protein lmo0331 [Listeria m...	633	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	3BZ5	28.4%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP01213 (show subtarget assignments)	1	expressed	No	BA_3251	30257808		3-oxoacyl-(acyl-carrier-protein) synthas...	329	Drug Target Function	Phase 2: March 2008	2EBD	34.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02442 (show subtarget assignments)	1	soluble	No	GBAA4092	47778244		prophage LambdaBa02, Clp protease family...	251	Drug target motif; Drug target functions	Phase 3: June 2008	2F6I	21.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02778 (show subtarget assignments)	1	cloned	No	CBU_0056	29540679		outer membrane protein TolC, putative [C...	616	Conserved; Drug target functions	Phase 3: June 2008	2VDD	27.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02444 (show subtarget assignments)	1	cloned	No	YPO2224	16122453		hypothetical protein YPO2224 [Yersinia p...	103	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP01215 (show subtarget assignments)	1	expressed	No	BA_3506	30258044		penicillin-binding protein, putative	345	Drug Target Function	Phase 2: March 2008	2QMI	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02446 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0287	16802333		hypothetical protein lmo0287 [Listeria m...	237	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2OQR	48.1%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP01216 (show subtarget assignments)	1	expressed	No	BA_3577	30258105		glycosyl transferase, group 1 family pro...	270	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02448 (show subtarget assignments)	1	in_pdb 3KD3	No	FTT0568	56707697		hypothetical protein FTT0568 [Francisell...	216	Drug Target	Phase 3: June 2008	3KD3	100%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP01217 (show subtarget assignments)	1	expressed	No	BA_3695	30258216		S-layer protein, putative	510	Drug Target Function	Phase 2: March 2008	3PYW	10.2%	Bacillus anthracis	Cell envelope	Surface structures

IDP01218 (show subtarget assignments)	1	expressed	No	BA_3712	73919984		Histidine ammonia-lyase (Histidase)	505	Drug Target Function	Phase 2: March 2008	1GK2	42%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02451 (show subtarget assignments)	1	in_pdb 3IMI	No	GBAA1047	47526323		HIT family protein [Bacillus anthracis s...	144	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3IMI	100%	Bacillus anthracis	Unknown function	General

IDP02452 (show subtarget assignments)	1	purified	No	GBAA3312	47528597		diaminobutyrate--2-oxoglutarate aminotra...	424	Conserved; Essential; Drug target functions	Phase 3: June 2008	2EH6	31.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01219 (show subtarget assignments)	1	purified	No	BA_3767	30258283		prophage LambdaBa01, N-acetylmuramoyl-L-...	310	Drug Target Function	Phase 2: March 2008	2L47	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00004 (show subtarget assignments)	1	soluble	No	BA_0001	38257418		Chromosomal replication initiator protei...	446	Drug Target Homolog	Phase 1: October 2007	2Z4R	37.2%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP02455 (show subtarget assignments)	1	expressed	No	GBAA3813	47529098		prophage LambdaBa01, thymidylate synthas...	252	Conserved; Drug target functions	Phase 3: June 2008	3AH5	24.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP04715 (show subtarget assignments)	1	expressed	No	YPO0813	115346604		general secretion pathway protein G [Yer...	145	drug target; putative drug target function;	Phase 4: April 2009	3G20	51%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02457 (show subtarget assignments)	1	expressed	No	FTT1248	56708310		ABC transporter, ATP-binding protein [Fr...	253	Drug Target	Phase 3: June 2008	1B0U	31.1%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02458 (show subtarget assignments)	1	in_pdb 3KUX	Yes	YPO2259	16122483		putative oxidoreductase [Yersinia pestis...	349	Conserved; Drug target functions	Phase 3: June 2008	3KUX	100%	Yersinia pestis	Central intermediary metabolism	Other

IDP02459 (show subtarget assignments)	1	soluble	No	lmo2067	16804106		hypothetical protein lmo2067 [Listeria m...	325	Known virulence-Bile resistance; PMID:15664931	Phase 3: June 2008	2BJF	38.8%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP01223 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4051	60390084		UDP-N-acetylmuramoylalanine--D-glutamate...	450	Conserved Gene / Pathway	Phase 2: March 2008	3LK7	52.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02461 (show subtarget assignments)	1	cloned	No	Cj0176c	15791563		putative lipoprotein [Campylobacter jeju...	43	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Cations and iron carrying compounds

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04109 (show subtarget assignments)	1	crystallized	No	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP02464 (show subtarget assignments)	1	cloned	No	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP01225 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4139	61211625		Phosphopantetheine adenylyltransferase (...	163	Drug Target Function	Phase 2: March 2008	1O6B	71.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02466 (show subtarget assignments)	1	crystallized	No	YPO1771	16122025		L-serine dehydratase [Yersinia pestis CO...	454	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2IQQ	17%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01226 (show subtarget assignments)	0	work_stopped	No	BA_4187	39931064		Peptide deformylase 2 (PDF 2) (Polypepti...	184	Drug Target Function	Phase 2: March 2008	2OKL	96.2%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP02468 (show subtarget assignments)	1	cloned	No	Cj0914c	15792243		invasion antigen B [Campylobacter jejuni...	610	Known Predicted virulence-invasion; PMID:10339609	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP00641 (show subtarget assignments)	1	purified	No	SACOL1866	57284787		serine protease SplD, putative	239	Drug Target Function	Phase 2: March 2008	2VID	43.5%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02470 (show subtarget assignments)	1	purified	No	lmo0865	16802906		hypothetical protein lmo0865 [Listeria m...	557	Predicted involvement in glycosyl group metabolism; DNA binding Motifs	Phase 3: June 2008	1TUO	26.2%	Listeria monocytogenes	Energy metabolism	Sugars

IDP02471 (show subtarget assignments)	1	cloned	No	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP02472 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3785	16123919		hypothetical protein YPO3785 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1YWF	26.2%	Yersinia pestis	Energy metabolism	Sugars

IDP01229 (show subtarget assignments)	1	soluble	No	BA_4540	52782922		Protein grpE (HSP-70 cofactor)	188	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	34.9%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01230 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4638	33300883		Adenine phosphoribosyltransferase (APRT)...	170	Drug Target Function	Phase 2: March 2008	2DY0	52.4%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02475 (show subtarget assignments)	1	cloned	No	GBAA3660	47528945		serine protease [Bacillus anthracis str....	413	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZLE	30%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00643 (show subtarget assignments)	1	purified	No	SACOL2638	57286542		precorrin-2 dehydrogenase	201	Conserved Gene / Pathway	Phase 2: March 2008	3DFZ	33.8%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02477 (show subtarget assignments)	1	cloned	No	YPO2035	16122274		hypothetical protein YPO2035 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1ZCC	23.6%	Yersinia pestis	Central intermediary metabolism	Other

IDP00319 (show subtarget assignments)	1	expressed	No	CBU_2070	29655348		chorismate mutase, putative	136	Drug Target Function	Phase 2: March 2008			Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP04183 (show subtarget assignments)	1	expressed	No	VCA0257	15601025		sensor histidine kinase [Vibrio cholerae...	484	drug target; putative drug target function;	Phase 4: April 2009			Vibrio cholerae	Regulatory functions	Other

IDP00644 (show subtarget assignments)	1	expressed	No	SACOL0220	57286684		flavohemoprotein, putative	381	Conserved Gene / Pathway	Phase 2: March 2008	1CQX	36.9%	Staphylococcus aureus	Unknown function	General

IDP02481 (show subtarget assignments)	1	cloned	No	Cj1139c	15792464		putative galactosyltransferase [Campylob...	303	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3BCV	24.1%	Campylobacter jejuni	DNA metabolism	DNA replication, recombination, and repair

IDP01234 (show subtarget assignments)	0	work_stopped	No	BA_5509	30259969		UDP-N-acetylglucosamine 2-epimerase	371	Drug Target Function	Phase 2: March 2008	3BEO	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04236 (show subtarget assignments)	1	expressed	No	CPF_0837	110799475		sensor histidine kinase [Clostridium per...	336	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP02484 (show subtarget assignments)	1	expressed	No	GBAA3922	47529214		zinc protease [Bacillus anthracis str. '...	428	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HDI	24.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02485 (show subtarget assignments)	1	cloned	No	FTT1539c	56708571		hypothetical protein FTT1539c [Francisel...	476	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02486 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4209	47529502		Ppx/GppA phosphatase family protein [Bac...	512	Conserved; Drug target functions	Phase 3: June 2008	3HI0	23%	Bacillus anthracis	Central intermediary metabolism	Phosphorus compounds

IDP01236 (show subtarget assignments)	1	expressed	No	BA_5514	30259974		glycosyl transferase, group 1 family pro...	550	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01237 (show subtarget assignments)	1	purified	No	BA_5563	46396830		Glucose-specific phosphotransferase enzy...	165	Drug Target Function	Phase 2: March 2008	1GGR	46.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00647 (show subtarget assignments)	1	selected	No	SACOL1657	57286179		enterotoxin type A, putative	234	Virulence Associated Factor	Phase 2: March 2008	1ESF	40.2%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01238 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5635	30260086		lipoate-protein ligase A, putative	281	Drug Target Function	Phase 2: March 2008	2P5I	60.1%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP02491 (show subtarget assignments)	1	cloned	No	YPO1811	16122063		short chain dehydrogenase [Yersinia pest...	688	Conserved; CD; Drug target functions	Phase 3: June 2008	3U0B	14.8%	Yersinia pestis	Central intermediary metabolism	Other

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04161 (show subtarget assignments)	1	cloned	No	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP02494 (show subtarget assignments)	1	cloned	No	GBAA0550	47525823		hypothetical protein GBAA0550 [Bacillus ...	631	Drug target motif; Conserved;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP00648 (show subtarget assignments)	1	cloned	No	SACOL2160	57286373		hemolysin III, putative	227	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01241 (show subtarget assignments)	1	expressed	No	BA_1474	30255405		penicillin-binding protein	673	Drug Target Function	Phase 2: March 2008	2JCH	28.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00649 (show subtarget assignments)	1	in_pdb 3R2U	No	SACOL0046	57286601		metallo-beta-lactamase family protein	442	Drug Target Function	Phase 2: March 2008	3R2U	100%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP01242 (show subtarget assignments)	1	soluble	No	BA_1572	30255873		penicillin-binding protein	897	Drug Target Function	Phase 2: March 2008	2OLU	27.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02499 (show subtarget assignments)	1	in_pdb 3I3O 3IJR	No	GBAA0748	47526031		short chain dehydrogenase [Bacillus anth...	288	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3I3O	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02500 (show subtarget assignments)	1	in_pdb 3SY3 3TJ7	Yes	GBAA1210	47526472		hypothetical protein GBAA1210 [Bacillus ...	192	Drug target motif;	Phase 3: June 2008	3SY3	99.5%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01243 (show subtarget assignments)	1	cloned	No	BA_2345	30256982		penicillin-binding protein 1A	820	Drug Target Function	Phase 2: March 2008	2OLU	29.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02502 (show subtarget assignments)	1	expressed	No	Cj1341c	15792664		hypothetical protein Cj1341c [Campylobac...	607	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008			Campylobacter jejuni	Unclassified	Role category not yet assigned

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02505 (show subtarget assignments)	1	in_pdb 3QAO	No	lmo0526	16802569		hypothetical protein lmo0526 [Listeria m...	246	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	3QAO	100%	Listeria monocytogenes	Regulatory functions	Other

IDP02506 (show subtarget assignments)	1	soluble	No	FTT0609	56707734		peptidase, M24 family protein [Francisel...	597	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3CTZ	37.4%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02508 (show subtarget assignments)	1	cloned	No	lmo1847	16803887		hypothetical protein lmo1847 [Listeria m...	310	Known virulence-Invasion; PMID:12496198	Phase 3: June 2008	1PSZ	52.3%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP02509 (show subtarget assignments)	1	crystallized	No	STM1809	16765150		putative cytoplasmic protein [Salmonella...	57	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02510 (show subtarget assignments)	1	expressed	No	YPO2285	16122509		putative ribose-binding periplasmic prot...	208	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	35.6%	Yersinia pestis	N/A	N/A

IDP01248 (show subtarget assignments)	1	soluble	No	BA_3554	30258085		penicillin-binding protein, putative	377	Drug Target Function	Phase 2: March 2008	3TG9	23.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02513 (show subtarget assignments)	1	soluble	No	GBAA0258	47525517		hypothetical protein GBAA0258 [Bacillus ...	157	Conserved;	Phase 3: June 2008	1FL9	30.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01250 (show subtarget assignments)	1	cloned	No	BA_4497	30259003		penicillin-binding protein	706	Drug Target Function	Phase 2: March 2008	2WAF	33%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04610 (show subtarget assignments)	1	in_pdb 3RFO	No	BAS3717	49186716		methionyl-tRNA formyltransferase [Bacill...	314	Proposed to be essential proteins	Phase 4: April 2009	3RFO	100%	Bacillus anthracis

IDP01251 (show subtarget assignments)	1	cloned	No	BA_4606	30259106		penicillin-binding protein	584	Drug Target Function	Phase 2: March 2008	3OC2	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02517 (show subtarget assignments)	1	purified	No	GBAA2315	47527614		S-layer protein, putative [Bacillus anth...	383	Drug target motif; Drug target functions	Phase 3: June 2008	3PYW	15.9%	Bacillus anthracis	Cell envelope	Surface structures

IDP01252 (show subtarget assignments)	1	cloned	No	BA_5623	30260075		penicillin-binding protein	683	Drug Target Function	Phase 2: March 2008	3UDF	28.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02642 (show subtarget assignments)	1	cloned	No	GBAA5626	47778419		4-oxalocrotonate tautomerase [Bacillus a...	61	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OP8	78.7%	Bacillus anthracis	Energy metabolism	Other

IDP01253 (show subtarget assignments)	1	cloned	No	BA_2575	30257197		penicillin-binding protein, putative	481	Drug Target Function	Phase 2: March 2008	2QMI	20%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04011 (show subtarget assignments)	1	cloned	No	CPF_2475	110800353		stage II sporulation protein R [Clostrid...	209	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01254 (show subtarget assignments)	1	in_pdb 4ECM 3HL3	Yes	BA_1228	30255177		glucose-1-phosphate thymidylyltransferas...	245	Conserved Gene / Pathway	Phase 2: March 2008	3HL3	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04604 (show subtarget assignments)	1	cloned	No	BAS3678	49186677		30S ribosomal protein S2 [Bacillus anthr...	233	Proposed to be essential proteins	Phase 4: April 2009	1FJG	56.2%	Bacillus anthracis

IDP04150 (show subtarget assignments)	1	purified	No	YPO3707	115349324		conserved hypothetical protein [Yersinia...	165	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP90109 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_014	68449088		interleukin-18-binding protein [Monkeypo...	126	similar to VACWR-C12L,VARV-BSH75_banu-D7L, MPXV-ZAI96-D6L	Community Requests	3F62	79.4%	Monkeypox virus

IDP04618 (show subtarget assignments)	1	cloned	No	BAS4456	49187451		phenylalanyl-tRNA synthetase subunit alp...	344	Proposed to be essential proteins	Phase 4: April 2009	2RHQ	57.6%	Bacillus anthracis

IDP02527 (show subtarget assignments)	1	in_pdb 3L4E	No	lmo0363	16802408		hypothetical protein lmo0363 [Listeria m...	205	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3L4E	100%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP91329 (show subtarget assignments)	8	soluble	No	VV2_0264	27366713		signal transduction protein [Vibrio vuln...	638	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3PJW	18.5%	Vibrio vulnificus

IDP91328 (show subtarget assignments)	8	expressed	No	VV2_0290	27366736		ribonuclease G and E [Vibrio vulnificus ...	105	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP02430
(show subtarget assignments)

1

expressed

No

FTT1151c

56708222

hypothetical protein FTT1151c [Francisel...

95

Drug Target

Phase 3: June 2008

2JR5

25.3%

Francisella tularensis

Unknown function

General

IDP02431
(show subtarget assignments)

1

crystallized

No

CBU_1770

29542327

ABC transporter, ATP-binding protein [Co...

432

Conserved; Drug target functions

Phase 3: June 2008

2YYZ

23.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02432
(show subtarget assignments)

1

soluble

No

GBAA3687

47528971

acetyl-CoA acetyltransferase [Bacillus a...

363

Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...

Phase 3: June 2008

4DD5

39.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP01209
(show subtarget assignments)

1

soluble

No

BA_2650

30257267

penicillin-binding protein

340

Drug Target Function

Phase 2: March 2008

3TG9

53.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01210
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2805

30257409

glycosyl hydrolase, family 25, putative ...

268

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

61.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05095
(show subtarget assignments)

1

soluble

No

BA_5481

30259944

conserved domain protein [Bacillus anthr...

290

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP02436
(show subtarget assignments)

1

cloned

No

Cj1418c

15792736

hypothetical protein Cj1418c [Campylobac...

779

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Energy metabolism

Electron transport

IDP01211
(show subtarget assignments)

1

crystallized

No

BA_2958

30257549

chorismate mutase/phospho-2-dehydro-3-de...

358

Drug Target Function

Phase 2: March 2008

3NVT

69.8%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02438
(show subtarget assignments)

1

cloned

No

CBU_0029

29540654

acyltransferase family protein [Coxiella...

242

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP02439
(show subtarget assignments)

1

cloned

No

GBAA3892

47529180

serine protease [Bacillus anthracis str....

613

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2OXA

16.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02440
(show subtarget assignments)

1

cloned

No

lmo0331

16802376

hypothetical protein lmo0331 [Listeria m...

633

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

3BZ5

28.4%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP01213
(show subtarget assignments)

1

expressed

No

BA_3251

30257808

3-oxoacyl-(acyl-carrier-protein) synthas...

329

Drug Target Function

Phase 2: March 2008

2EBD

34.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02442
(show subtarget assignments)

1

soluble

No

GBAA4092

47778244

prophage LambdaBa02, Clp protease family...

251

Drug target motif; Drug target functions

Phase 3: June 2008

2F6I

21.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02778
(show subtarget assignments)

1

cloned

No

CBU_0056

29540679

outer membrane protein TolC, putative [C...

616

Conserved; Drug target functions

Phase 3: June 2008

2VDD

27.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02444
(show subtarget assignments)

1

cloned

No

YPO2224

16122453

hypothetical protein YPO2224 [Yersinia p...

103

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP01215
(show subtarget assignments)

1

expressed

No

BA_3506

30258044

penicillin-binding protein, putative

345

Drug Target Function

Phase 2: March 2008

2QMI

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02446
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0287

16802333

hypothetical protein lmo0287 [Listeria m...

237

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2OQR

48.1%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP01216
(show subtarget assignments)

1

expressed

No

BA_3577

30258105

glycosyl transferase, group 1 family pro...

270

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02448
(show subtarget assignments)

1

in_pdb
3KD3

No

FTT0568

56707697

hypothetical protein FTT0568 [Francisell...

216

Drug Target

Phase 3: June 2008

3KD3

100%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP01217
(show subtarget assignments)

1

expressed

No

BA_3695

30258216

S-layer protein, putative

510

Drug Target Function

Phase 2: March 2008

3PYW

10.2%

Bacillus anthracis

Cell envelope

Surface structures

IDP01218
(show subtarget assignments)

1

expressed

No

BA_3712

73919984

Histidine ammonia-lyase (Histidase)

505

Drug Target Function

Phase 2: March 2008

1GK2

42%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02451
(show subtarget assignments)

1

in_pdb
3IMI

No

GBAA1047

47526323

HIT family protein [Bacillus anthracis s...

144

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3IMI

100%

Bacillus anthracis

Unknown function

General

IDP02452
(show subtarget assignments)

1

purified

No

GBAA3312

47528597

diaminobutyrate--2-oxoglutarate aminotra...

424

Conserved; Essential; Drug target functions

Phase 3: June 2008

2EH6

31.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01219
(show subtarget assignments)

1

purified

No

BA_3767

30258283

prophage LambdaBa01, N-acetylmuramoyl-L-...

310

Drug Target Function

Phase 2: March 2008

2L47

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00004
(show subtarget assignments)

1

soluble

No

BA_0001

38257418

Chromosomal replication initiator protei...

446

Drug Target Homolog

Phase 1: October 2007

2Z4R

37.2%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP02455
(show subtarget assignments)

1

expressed

No

GBAA3813

47529098

prophage LambdaBa01, thymidylate synthas...

252

Conserved; Drug target functions

Phase 3: June 2008

3AH5

24.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP04715
(show subtarget assignments)

1

expressed

No

YPO0813

115346604

general secretion pathway protein G [Yer...

145

drug target; putative drug target function;

Phase 4: April 2009

3G20

51%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02457
(show subtarget assignments)

1

expressed

No

FTT1248

56708310

ABC transporter, ATP-binding protein [Fr...

253

Drug Target

Phase 3: June 2008

1B0U

31.1%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02458
(show subtarget assignments)

1

in_pdb
3KUX

Yes

YPO2259

16122483

putative oxidoreductase [Yersinia pestis...

349

Conserved; Drug target functions

Phase 3: June 2008

3KUX

100%

Yersinia pestis

Central intermediary metabolism

Other

IDP02459
(show subtarget assignments)

1

soluble

No

lmo2067

16804106

hypothetical protein lmo2067 [Listeria m...

325

Known virulence-Bile resistance; PMID:15664931

Phase 3: June 2008

2BJF

38.8%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP01223
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4051

60390084

UDP-N-acetylmuramoylalanine--D-glutamate...

450

Conserved Gene / Pathway

Phase 2: March 2008

3LK7

52.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02461
(show subtarget assignments)

1

cloned

No

Cj0176c

15791563

putative lipoprotein [Campylobacter jeju...

43

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Cations and iron carrying compounds

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04109
(show subtarget assignments)

1

crystallized

No

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP02464
(show subtarget assignments)

1

cloned

No

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP01225
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4139

61211625

Phosphopantetheine adenylyltransferase (...

163

Drug Target Function

Phase 2: March 2008

1O6B

71.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02466
(show subtarget assignments)

1

crystallized

No

YPO1771

16122025

L-serine dehydratase [Yersinia pestis CO...

454

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2IQQ

17%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01226
(show subtarget assignments)

0

work_stopped

No

BA_4187

39931064

Peptide deformylase 2 (PDF 2) (Polypepti...

184

Drug Target Function

Phase 2: March 2008

2OKL

96.2%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP02468
(show subtarget assignments)

1

cloned

No

Cj0914c

15792243

invasion antigen B [Campylobacter jejuni...

610

Known Predicted virulence-invasion; PMID:10339609

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP00641
(show subtarget assignments)

1

purified

No

SACOL1866

57284787

serine protease SplD, putative

239

Drug Target Function

Phase 2: March 2008

2VID

43.5%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02470
(show subtarget assignments)

1

purified

No

lmo0865

16802906

hypothetical protein lmo0865 [Listeria m...

557

Predicted involvement in glycosyl group metabolism; DNA binding Motifs

Phase 3: June 2008

1TUO

26.2%

Listeria monocytogenes

Energy metabolism

Sugars

IDP02471
(show subtarget assignments)

1

cloned

No

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP02472
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3785

16123919

hypothetical protein YPO3785 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1YWF

26.2%

Yersinia pestis

Energy metabolism

Sugars

IDP01229
(show subtarget assignments)

1

soluble

No

BA_4540

52782922

Protein grpE (HSP-70 cofactor)

188

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

34.9%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01230
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4638

33300883

Adenine phosphoribosyltransferase (APRT)...

170

Drug Target Function

Phase 2: March 2008

2DY0

52.4%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02475
(show subtarget assignments)

1

cloned

No

GBAA3660

47528945

serine protease [Bacillus anthracis str....

413

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZLE

30%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00643
(show subtarget assignments)

1

purified

No

SACOL2638

57286542

precorrin-2 dehydrogenase

201

Conserved Gene / Pathway

Phase 2: March 2008

3DFZ

33.8%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02477
(show subtarget assignments)

1

cloned

No

YPO2035

16122274

hypothetical protein YPO2035 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1ZCC

23.6%

Yersinia pestis

Central intermediary metabolism

Other

IDP00319
(show subtarget assignments)

1

expressed

No

CBU_2070

29655348

chorismate mutase, putative

136

Drug Target Function

Phase 2: March 2008

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP04183
(show subtarget assignments)

1

expressed

No

VCA0257

15601025

sensor histidine kinase [Vibrio cholerae...

484

drug target; putative drug target function;

Phase 4: April 2009

Vibrio cholerae

Regulatory functions

Other

IDP00644
(show subtarget assignments)

1

expressed

No

SACOL0220

57286684

flavohemoprotein, putative

381

Conserved Gene / Pathway

Phase 2: March 2008

1CQX

36.9%

Staphylococcus aureus

Unknown function

General

IDP02481
(show subtarget assignments)

1

cloned

No

Cj1139c

15792464

putative galactosyltransferase [Campylob...

303

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3BCV

24.1%

Campylobacter jejuni

DNA metabolism

DNA replication, recombination, and repair

IDP01234
(show subtarget assignments)

0

work_stopped

No

BA_5509

30259969

UDP-N-acetylglucosamine 2-epimerase

371

Drug Target Function

Phase 2: March 2008

3BEO

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04236
(show subtarget assignments)

1

expressed

No

CPF_0837

110799475

sensor histidine kinase [Clostridium per...

336

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP02484
(show subtarget assignments)

1

expressed

No

GBAA3922

47529214

zinc protease [Bacillus anthracis str. '...

428

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HDI

24.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02485
(show subtarget assignments)

1

cloned

No

FTT1539c

56708571

hypothetical protein FTT1539c [Francisel...

476

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02486
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4209

47529502

Ppx/GppA phosphatase family protein [Bac...

512

Conserved; Drug target functions

Phase 3: June 2008

3HI0

23%

Bacillus anthracis

Central intermediary metabolism

Phosphorus compounds

IDP01236
(show subtarget assignments)

1

expressed

No

BA_5514

30259974

glycosyl transferase, group 1 family pro...

550

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01237
(show subtarget assignments)

1

purified

No

BA_5563

46396830

Glucose-specific phosphotransferase enzy...

165

Drug Target Function

Phase 2: March 2008

1GGR

46.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00647
(show subtarget assignments)

1

selected

No

SACOL1657

57286179

enterotoxin type A, putative

234

Virulence Associated Factor

Phase 2: March 2008

1ESF

40.2%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01238
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5635

30260086

lipoate-protein ligase A, putative

281

Drug Target Function

Phase 2: March 2008

2P5I

60.1%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP02491
(show subtarget assignments)

1

cloned

No

YPO1811

16122063

short chain dehydrogenase [Yersinia pest...

688

Conserved; CD; Drug target functions

Phase 3: June 2008

3U0B

14.8%

Yersinia pestis

Central intermediary metabolism

Other

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04161
(show subtarget assignments)

1

cloned

No

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP02494
(show subtarget assignments)

1

cloned

No

GBAA0550

47525823

hypothetical protein GBAA0550 [Bacillus ...

631

Drug target motif; Conserved;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP00648
(show subtarget assignments)

1

cloned

No

SACOL2160

57286373

hemolysin III, putative

227

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01241
(show subtarget assignments)

1

expressed

No

BA_1474

30255405

penicillin-binding protein

673

Drug Target Function

Phase 2: March 2008

2JCH

28.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00649
(show subtarget assignments)

1

in_pdb
3R2U

No

SACOL0046

57286601

metallo-beta-lactamase family protein

442

Drug Target Function

Phase 2: March 2008

3R2U

100%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP01242
(show subtarget assignments)

1

soluble

No

BA_1572

30255873

penicillin-binding protein

897

Drug Target Function

Phase 2: March 2008

2OLU

27.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02499
(show subtarget assignments)

1

in_pdb
3I3O
3IJR

No

GBAA0748

47526031

short chain dehydrogenase [Bacillus anth...

288

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3I3O

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02500
(show subtarget assignments)

1

in_pdb
3SY3
3TJ7

Yes

GBAA1210

47526472

hypothetical protein GBAA1210 [Bacillus ...

192

Drug target motif;

Phase 3: June 2008

3SY3

99.5%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01243
(show subtarget assignments)

1

cloned

No

BA_2345

30256982

penicillin-binding protein 1A

820

Drug Target Function

Phase 2: March 2008

2OLU

29.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02502
(show subtarget assignments)

1

expressed

No

Cj1341c

15792664

hypothetical protein Cj1341c [Campylobac...

607

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

Campylobacter jejuni

Unclassified

Role category not yet assigned

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02505
(show subtarget assignments)

1

in_pdb
3QAO

No

lmo0526

16802569

hypothetical protein lmo0526 [Listeria m...

246

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

3QAO

100%

Listeria monocytogenes

Regulatory functions

Other

IDP02506
(show subtarget assignments)

1

soluble

No

FTT0609

56707734

peptidase, M24 family protein [Francisel...

597

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3CTZ

37.4%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02508
(show subtarget assignments)

1

cloned

No

lmo1847

16803887

hypothetical protein lmo1847 [Listeria m...

310

Known virulence-Invasion; PMID:12496198

Phase 3: June 2008

1PSZ

52.3%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP02509
(show subtarget assignments)

1

crystallized

No

STM1809

16765150

putative cytoplasmic protein [Salmonella...

57

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02510
(show subtarget assignments)

1

expressed

No

YPO2285

16122509

putative ribose-binding periplasmic prot...

208

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

35.6%

Yersinia pestis

N/A

IDP01248
(show subtarget assignments)

1

soluble

No

BA_3554

30258085

penicillin-binding protein, putative

377

Drug Target Function

Phase 2: March 2008

3TG9

23.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02513
(show subtarget assignments)

1

soluble

No

GBAA0258

47525517

hypothetical protein GBAA0258 [Bacillus ...

157

Conserved;

Phase 3: June 2008

1FL9

30.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01250
(show subtarget assignments)

1

cloned

No

BA_4497

30259003

penicillin-binding protein

706

Drug Target Function

Phase 2: March 2008

2WAF

33%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04610
(show subtarget assignments)

1

in_pdb
3RFO

No

BAS3717

49186716

methionyl-tRNA formyltransferase [Bacill...

314

Proposed to be essential proteins

Phase 4: April 2009

3RFO

100%

Bacillus anthracis

IDP01251
(show subtarget assignments)

1

cloned

No

BA_4606

30259106

penicillin-binding protein

584

Drug Target Function

Phase 2: March 2008

3OC2

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02517
(show subtarget assignments)

1

purified

No

GBAA2315

47527614

S-layer protein, putative [Bacillus anth...

383

Drug target motif; Drug target functions

Phase 3: June 2008

3PYW

15.9%

Bacillus anthracis

Cell envelope

Surface structures

IDP01252
(show subtarget assignments)

1

cloned

No

BA_5623

30260075

penicillin-binding protein

683

Drug Target Function

Phase 2: March 2008

3UDF

28.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02642
(show subtarget assignments)

1

cloned

No

GBAA5626

47778419

4-oxalocrotonate tautomerase [Bacillus a...

61

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OP8

78.7%

Bacillus anthracis

Energy metabolism

Other

IDP01253
(show subtarget assignments)

1

cloned

No

BA_2575

30257197

penicillin-binding protein, putative

481

Drug Target Function

Phase 2: March 2008

2QMI

20%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04011
(show subtarget assignments)

1

cloned

No

CPF_2475

110800353

stage II sporulation protein R [Clostrid...

209

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01254
(show subtarget assignments)

1

in_pdb
4ECM
3HL3

Yes

BA_1228

30255177

glucose-1-phosphate thymidylyltransferas...

245

Conserved Gene / Pathway

Phase 2: March 2008

3HL3

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04604
(show subtarget assignments)

1

cloned

No

BAS3678

49186677

30S ribosomal protein S2 [Bacillus anthr...

233

Proposed to be essential proteins

Phase 4: April 2009

1FJG

56.2%

Bacillus anthracis

IDP04150
(show subtarget assignments)

1

purified

No

YPO3707

115349324

conserved hypothetical protein [Yersinia...

165

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP90109
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_014

68449088

interleukin-18-binding protein [Monkeypo...

126

Community Requests

3F62

79.4%

Monkeypox virus

IDP04618
(show subtarget assignments)

1

cloned

No

BAS4456

49187451

phenylalanyl-tRNA synthetase subunit alp...

344

Proposed to be essential proteins

Phase 4: April 2009

2RHQ

57.6%

Bacillus anthracis

IDP02527
(show subtarget assignments)

1

in_pdb
3L4E

No

lmo0363

16802408

hypothetical protein lmo0363 [Listeria m...

205

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3L4E

100%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP91329
(show subtarget assignments)

8

soluble

No

VV2_0264

27366713

signal transduction protein [Vibrio vuln...

638

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3PJW

18.5%

Vibrio vulnificus

IDP91328
(show subtarget assignments)

8

expressed

No

VV2_0290

27366736

ribonuclease G and E [Vibrio vulnificus ...

105

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus